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PMID:28802 | [Status of T- and B-lymphocytes in long living CBA--F1 (CBA X C57BL/6) chimeras]. | Semiallogeneic chimeras were produced by injecting 3 X 10(7) spleen cells of mice CBA (H--2k, Mlsd) to lethally irradiated mice (CBA X C57BL/6)F1. Two days later recipients were given cyclophosphamide (CP), 2 mg per mouse, to prevent death of graft versus host reaction (GVHR). For 1.5--2 months after the creation of ch... | [Status of T- and B-lymphocytes in long living CBA--F1 (CBA X C57BL/6) chimeras]. Semiallogeneic chimeras were produced by injecting 3 X 10(7) spleen cells of mice CBA (H--2k, Mlsd) to lethally irradiated mice (CBA X C57BL/6)F1. Two days later recipients were given cyclophosphamide (CP), 2 mg per mouse, to prevent deat... | [
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PMID:28806 | The effects of uptake1 on alpha-adrenoceptor antagonist potency in dog saphenous vein. | 1 The effects of alpha-adrenoceptor antagonists on contractile responses to noradrenaline and methoxamine were examined in isolated saphenous vein strips of the dog. 2 Phentolamine, labetalol and thymoxamine antagonized responses to methoxamine to a greater extent than responses to noradrenaline. 3 Cocaine (3.0 x 10(-5... | The effects of uptake1 on alpha-adrenoceptor antagonist potency in dog saphenous vein. 1 The effects of alpha-adrenoceptor antagonists on contractile responses to noradrenaline and methoxamine were examined in isolated saphenous vein strips of the dog. 2 Phentolamine, labetalol and thymoxamine antagonized responses to ... | [
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PMID:28807 | The effects of alpha-adrenoceptor antagonists on contractile responses to 5-hydroxytryptamine in dog saphenous vein. | 1 5-Hydroxytryptamine (5-HT) contracted isolated saphenous vein strips of the dog, producing a biphasic concentration-effect curve. The first phase occurred with low concentrations of 5-HT (1.0 X 10(-8) TO 5.0 X 10(-6) mol/l) with a plateau between 1.0 x 10(-6) mol/l and 1.0 x 10(-5) mol/l. The second phase occurred wi... | The effects of alpha-adrenoceptor antagonists on contractile responses to 5-hydroxytryptamine in dog saphenous vein. 1 5-Hydroxytryptamine (5-HT) contracted isolated saphenous vein strips of the dog, producing a biphasic concentration-effect curve. The first phase occurred with low concentrations of 5-HT (1.0 X 10(-8) ... | [
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PMID:28808 | The effects of piperoxan on uptake of noradrenaline and overflow of transmitter in the isolated blood perfused spleen of the cat. | 1 The competitive alpha-adrenoceptor blocking agent, piperoxan, in concentrations up to 2 x 10(-4) M, produced large dose-dependent increases in transmitter overflow from the isolated blood perfused spleen of the cat following nerve stimulation at 10 hertz. 2 At concentrations greater than 2 x 10(-4) M, piperoxan produ... | The effects of piperoxan on uptake of noradrenaline and overflow of transmitter in the isolated blood perfused spleen of the cat. 1 The competitive alpha-adrenoceptor blocking agent, piperoxan, in concentrations up to 2 x 10(-4) M, produced large dose-dependent increases in transmitter overflow from the isolated blood ... | [
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PMID:28810 | Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension. | Atenolol was compared with five other beta-blockers and a thiazide diuretic in a randomised cross-over trial of once-daily treatment of essential hypertension. Atenolol was significantly better at reducing resting and exercise blood pressures at 24 hours than any of the other drugs and had a low incidence of side effec... | Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension. Atenolol was compared with five other beta-blockers and a thiazide diuretic in a randomised cross-over trial of once-daily treatment of essential hypertension. Atenolol was significantly better at reducing resting and exercise bloo... | [
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PMID:28811 | Need for beta-blockade in hypertension reduced with long-term minoxidil. | Sequential changes in plasma renin activity and urinary aldosterone and noradrenaline were assessed in eight patients with severe hypertension after minoxidil had been added to their treatment. Doses of 2.5--27.5 (mean 12.5) mg/day reduced the mean blood pressure from 166/113 +/-6/2 mm Hg to 124/88+/-4/2 mm Hg in one w... | Need for beta-blockade in hypertension reduced with long-term minoxidil. Sequential changes in plasma renin activity and urinary aldosterone and noradrenaline were assessed in eight patients with severe hypertension after minoxidil had been added to their treatment. Doses of 2.5--27.5 (mean 12.5) mg/day reduced the mea... | [
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PMID:28814 | Transmitter histochemistry of the rat olfactory bulb. II. Fluorescence histochemical, autoradiographic and electron microscopic localization of monoamines. | The rat olfactory bulb was studied with the Falck-Hillarp formaldehyde fluorescence technique, including recent modifications, autoradiography and electron microscopic cytochemistry (permanganate fixation). Some periglomerular cells and few superficial tufted cells take up and accumulate catecholamines and precursors. ... | Transmitter histochemistry of the rat olfactory bulb. II. Fluorescence histochemical, autoradiographic and electron microscopic localization of monoamines. The rat olfactory bulb was studied with the Falck-Hillarp formaldehyde fluorescence technique, including recent modifications, autoradiography and electron microsco... | [
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PMID:28817 | Kainic acid lesions of the striatum: behavioural sequalae similar to Huntington's chorea. | Kainic acid (3 nmoles bilaterally) was injected into the dorsal striatum of the rat producing virtually complete destruction of cell bodies in this structure but without directly affecting the dopamine terminals ascending from the substantia nigra and terminating in the striatum. Other fibres of passage, such as the in... | Kainic acid lesions of the striatum: behavioural sequalae similar to Huntington's chorea. Kainic acid (3 nmoles bilaterally) was injected into the dorsal striatum of the rat producing virtually complete destruction of cell bodies in this structure but without directly affecting the dopamine terminals ascending from the... | [
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PMID:28820 | The isolation and identification of 2,4-diketones present in human and animal tissues and in urine. | The chemical isolation of 2,3-diketone fraction from hydrolysates of various mammalian tissues has been accomplished by the use of a modified Girard T procedure. This fraction, which constitutes a new lipid class, has been resolved by gas chromatography into a number of homologous 2,4-diketones, ranging in chain length... | The isolation and identification of 2,4-diketones present in human and animal tissues and in urine. The chemical isolation of 2,3-diketone fraction from hydrolysates of various mammalian tissues has been accomplished by the use of a modified Girard T procedure. This fraction, which constitutes a new lipid class, has be... | [
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PMID:28821 | Kinetics of formation of the primary compound (compound I) from hydrogen peroxide and turnip peroxidases. | A kinetic study of the reaction of two turnip peroxidases (P1 and P7) with hydrogen peroxide to form the primary oxidized compound (compound I) has been carried out over the pH range from 2.4 to 10.8. In the neutral and acidic pH regions, the rates depend linearly on hydrogen peroxide concentration whereas at alkaline ... | Kinetics of formation of the primary compound (compound I) from hydrogen peroxide and turnip peroxidases. A kinetic study of the reaction of two turnip peroxidases (P1 and P7) with hydrogen peroxide to form the primary oxidized compound (compound I) has been carried out over the pH range from 2.4 to 10.8. In the neutra... | [
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PMID:28822 | Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP-ribosylation) of basic nuclear proteins. | The isolated nuclei of rat pancreas contain an enzyme system that will incorporate 3H-labeled NAD into an acid-insoluble product, which is shown to be poly(ADP-ribose). The enzyme has an optimum pH of 7.8 and the optimum temperature is between 20 and 30 degrees C. Optimum Mg2+ concentration is 8 mM and dithiothreitol a... | Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP-ribosylation) of basic nuclear proteins. The isolated nuclei of rat pancreas contain an enzyme system that will incorporate 3H-labeled NAD into an acid-insoluble product, which is shown to be poly(ADP-ribose). The enzyme has an optimum pH of 7.8 a... | [
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PMID:28823 | The effect of acid--base changes on skeletal muscle twitch tension. | The effects of acid--base alterations produced by changing bicarbonate (metabolic type), carbon dioxide tension (respiratory type), or both bicarbonate and carbon dioxide tension (compensated type) on skeletal muscle twitch tension, intracellular pH, and intracellular potassium were studied in vitro. Hemidiaphragm musc... | The effect of acid--base changes on skeletal muscle twitch tension. The effects of acid--base alterations produced by changing bicarbonate (metabolic type), carbon dioxide tension (respiratory type), or both bicarbonate and carbon dioxide tension (compensated type) on skeletal muscle twitch tension, intracellular pH, a... | [
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PMID:28825 | Effect of autonomic agents on the amount of androgen-dependent granules in convoluted tubular cells of the mouse submandibular gland. | The convoluted tubular cells of the male mouse submandibular gland contain many serous-like granules in their apical cytoplasm. The autonomic regulation of the secretory process of the contents of these granules was studied by the following two methods: (1) immunochemical method using an antiserum specific to the granu... | Effect of autonomic agents on the amount of androgen-dependent granules in convoluted tubular cells of the mouse submandibular gland. The convoluted tubular cells of the male mouse submandibular gland contain many serous-like granules in their apical cytoplasm. The autonomic regulation of the secretory process of the c... | [
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PMID:28827 | Recent developments in the supportive therapy of acute myelogenous leukemia. | The prognosis for patients with AML is improving, but mortality due to bleeding and infection remains significant. HLA compatibility has been the cornerstone of matching for prophylactic platelet transfusion; while HLA matched platelets are often of benefit, we have observed that HLA matching does not reliably predict ... | Recent developments in the supportive therapy of acute myelogenous leukemia. The prognosis for patients with AML is improving, but mortality due to bleeding and infection remains significant. HLA compatibility has been the cornerstone of matching for prophylactic platelet transfusion; while HLA matched platelets are of... | [
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PMID:28828 | Marrow transplantation for acute leukemia. | Marrow transplantation enables the physician to ignore the complications of marrow toxicity which limit the chemotherapy of leukemia and makes it possible to explore new drugs and regimens. The results of marrow transplantation for 154 cases of end-stage acute leukemia carried out by the Seattle Marrow Transplant Team ... | Marrow transplantation for acute leukemia. Marrow transplantation enables the physician to ignore the complications of marrow toxicity which limit the chemotherapy of leukemia and makes it possible to explore new drugs and regimens. The results of marrow transplantation for 154 cases of end-stage acute leukemia carried... | [
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PMID:28829 | Effects of cysteine upon tumor cells. | Cysteine had been reported to increase survival time in thymoma-bearing mice and the interpretation suggested was that this was due to inhibition of a collagenase activity associated with some tumor cells by a chelating action of cysteine. In the present work it was shown that cysteine was a particularly potent inhibit... | Effects of cysteine upon tumor cells. Cysteine had been reported to increase survival time in thymoma-bearing mice and the interpretation suggested was that this was due to inhibition of a collagenase activity associated with some tumor cells by a chelating action of cysteine. In the present work it was shown that cyst... | [
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PMID:28857 | Polyvalent pneumococcal polysaccharide vaccines. | A 14-valent pneumococcal vaccine has recently been licensed for general use after extensive testing in human subjects. Antibody production was satisfactory in 92% of individuals and a highly significant (76-92%) reduction was found in the rates for pneumococcal pneumonias caused by the capsular types present in the vac... | Polyvalent pneumococcal polysaccharide vaccines. A 14-valent pneumococcal vaccine has recently been licensed for general use after extensive testing in human subjects. Antibody production was satisfactory in 92% of individuals and a highly significant (76-92%) reduction was found in the rates for pneumococcal pneumonia... | [
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PMID:28858 | Use of a sulfate: hydrogen sulfate buffer to preserve urine for steroid analysis. | 1. HCI, commonly used to preserve urine for steroid analysis, cannot safely be supplied to out of town patients. 2. An equimolar mixture of Na2SO4 and NaHSO4 is a safe alternative which may be used to protect specimens en route to the laboratory. 3. Addition of bisulfate buffer to urine (20 g/l) reduced the pH to 2.0-3... | Use of a sulfate: hydrogen sulfate buffer to preserve urine for steroid analysis. 1. HCI, commonly used to preserve urine for steroid analysis, cannot safely be supplied to out of town patients. 2. An equimolar mixture of Na2SO4 and NaHSO4 is a safe alternative which may be used to protect specimens en route to the lab... | [
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PMID:28859 | Measurement of free calcium ion in capillary blood and serum. | We describe a new calcium ion-selective electrode for measurement of the substance concentration of free calcium ion [Ca2+] in the plasma phase of whole blood and in serum at 37 degrees C. A sample volume of 50 microliter suffices to obtain simultaneous values of pH and [Ca2+]. We found the within-series analytical sta... | Measurement of free calcium ion in capillary blood and serum. We describe a new calcium ion-selective electrode for measurement of the substance concentration of free calcium ion [Ca2+] in the plasma phase of whole blood and in serum at 37 degrees C. A sample volume of 50 microliter suffices to obtain simultaneous valu... | [
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PMID:28860 | An "oncometer" of clinical measurement of colloid osmotic pressure of plasma. | Measurement of colloid osmotic pressure complements measurements of pulmonary artery wedge pressure for assessing the risks of pulmonary edema and constitutes an increasingly important reference for purposes of guiding selection of colloid or crystalloid fluids in patients with acute cardiac disease. We describe a simp... | An "oncometer" of clinical measurement of colloid osmotic pressure of plasma. Measurement of colloid osmotic pressure complements measurements of pulmonary artery wedge pressure for assessing the risks of pulmonary edema and constitutes an increasingly important reference for purposes of guiding selection of colloid or... | [
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PMID:28861 | Quality control of measurements of pH, carbon dioxide tension, and total carbon dioxide in plasma. | We have measured total carbon dioxide in plasma with a new carbon dioxide analyzer, and compared the results with total carbon dioxide data derived from measurements of carbon dioxide tension and pH. The results agree sufficiently well to demonstrate that the new instrument provides a simple, efficient procedure for mo... | Quality control of measurements of pH, carbon dioxide tension, and total carbon dioxide in plasma. We have measured total carbon dioxide in plasma with a new carbon dioxide analyzer, and compared the results with total carbon dioxide data derived from measurements of carbon dioxide tension and pH. The results agree suf... | [
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PMID:28865 | Gaucher's disease. Factors affecting the 4-methylum-belliferyl-beta-D-glucosidase activity of cultured skin fibroblasts. | Phosphate-buffered saline was found to inhibit acid beta-glucosidase activity of cultured cells. This effect was attributable to both the pH and the chloride content of the phosphate-buffered saline. Washing the cells in sucrose (0.25M) to remove residual phosphate-buffered saline effectively eliminated this inhibition... | Gaucher's disease. Factors affecting the 4-methylum-belliferyl-beta-D-glucosidase activity of cultured skin fibroblasts. Phosphate-buffered saline was found to inhibit acid beta-glucosidase activity of cultured cells. This effect was attributable to both the pH and the chloride content of the phosphate-buffered saline.... | [
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PMID:28868 | Doses and dosage intervals of drugs--clinical practice and pharmacokinetic principles. | Outpatient prescriptions dispensed to 17,000 individuals in the county of Jämtland, Sweden, have been analyzed with regard to doses and dosage schedules. Two groups of drugs were studied; one group with marked interindividual variability in metabolism (antidepressants, beta receptor blockers, and phenytoin), the other ... | Doses and dosage intervals of drugs--clinical practice and pharmacokinetic principles. Outpatient prescriptions dispensed to 17,000 individuals in the county of Jämtland, Sweden, have been analyzed with regard to doses and dosage schedules. Two groups of drugs were studied; one group with marked interindividual variabi... | [
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PMID:28870 | Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide. | Ten healthy volunteers ingested single 15-mg doses of clorazepate dipotassium (CZP) with 60 ml of water, or with 60 ml of magnesium aluminum hydroxide (Maalox), on two occasions in a randomized, two-way crossover study. Plasma concentrations of desmethyldiazepam (DMDZ) were determined in multiple samples drawn during 4... | Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide. Ten healthy volunteers ingested single 15-mg doses of clorazepate dipotassium (CZP) with 60 ml of water, or with 60 ml of magnesium aluminum hydroxide (Maalox), on two occasions in a randomized, two-way crossover study. Plasma co... | [
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PMID:28875 | Abnormal sodium transport in leucocytes from patients with essential hypertension and the effect of treatment. | 1. In seventeen patients with untreated essential hypertension the sodium and water contents of leucocytes were significantly increased, whereas the rate constant for ouabain-sensitive sodium efflux was significantly reduced. 2. These abnormalities were not found in fourteen other patients with well-controlled hyperten... | Abnormal sodium transport in leucocytes from patients with essential hypertension and the effect of treatment. 1. In seventeen patients with untreated essential hypertension the sodium and water contents of leucocytes were significantly increased, whereas the rate constant for ouabain-sensitive sodium efflux was signif... | [
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PMID:28876 | Effect of pyratrione (a tyrosine hydroxylase inhibitor) in essential hypertension. | 1. A clinical study of pyratrione, a tyrosine hydroxylase inhibitor, has been carried out in essential hypertension. 2. Out of thirty-nine patients who received pyratrione, twenty-eight showed a significant decrease in blood pressure. | Effect of pyratrione (a tyrosine hydroxylase inhibitor) in essential hypertension. 1. A clinical study of pyratrione, a tyrosine hydroxylase inhibitor, has been carried out in essential hypertension. 2. Out of thirty-nine patients who received pyratrione, twenty-eight showed a significant decrease in blood pressure. | [
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PMID:28878 | The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. | 1. DL-Propranolol, L-propranolol, DL-alprenolol, pindolol (LB46), practolol, ICI 66082, sotalol and oxprenolol all produced prolonged falls in blood pressure and heart rate after intracerebroventricular administration in conscious normotensive cats. 2. Transient initial pressor responses and tachycardias were observed ... | The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. 1. DL-Propranolol, L-propranolol, DL-alprenolol, pindolol (LB46), practolol, ICI 66082, sotalol and oxprenolol all produced prolonged falls in blood pressure and heart rate after intracerebroventricular administrat... | [
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PMID:28880 | beta-Adrenergic receptors and renin release: studies with beta-adrenoreceptor-blocking agents in the conscious rabbit. | 1. Plasma renin activity (PRA) and mean blood pressure were studied in conscious rabbits infused with beta-adrenoreceptor antagonists. 2. Oxprenolol and DL-propranolol each significantly reduced PRA and blood pressure, but prindolol, which had a strong blood pressure-lowering effect, increased PRA. 3. When prindolol wa... | beta-Adrenergic receptors and renin release: studies with beta-adrenoreceptor-blocking agents in the conscious rabbit. 1. Plasma renin activity (PRA) and mean blood pressure were studied in conscious rabbits infused with beta-adrenoreceptor antagonists. 2. Oxprenolol and DL-propranolol each significantly reduced PRA an... | [
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PMID:28897 | Effect of drugs on the stimulation threshold of the human heart. | Clinical measurements were made of the effects of various drugs on the stimulation threshold of human heart [right ventricle]. Of antiarrhythmic drugs, a marked and prolonged elevation of the stimulation threshold was produced by procainamide, quinidine, and aimaline. Relatively short-lasting elevation was elicited by ... | Effect of drugs on the stimulation threshold of the human heart. Clinical measurements were made of the effects of various drugs on the stimulation threshold of human heart [right ventricle]. Of antiarrhythmic drugs, a marked and prolonged elevation of the stimulation threshold was produced by procainamide, quinidine, ... | [
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PMID:28898 | What are the driving forces for the proximal tubular H+ and Ca++ transport? The electrochemical gradient for Na+ and/or ATP. | The H+ ion secretion in the proximal tubule as revealed by the reabsorption of the glycodiazine buffer vanishes when the ambient solutions are sodium-free. The same holds for other Na+-dependent transport processes such as Ca++, phosphate, glucose and amino acid reabsorption. If Na+ transport is blocked by ouabain the ... | What are the driving forces for the proximal tubular H+ and Ca++ transport? The electrochemical gradient for Na+ and/or ATP. The H+ ion secretion in the proximal tubule as revealed by the reabsorption of the glycodiazine buffer vanishes when the ambient solutions are sodium-free. The same holds for other Na+-dependent ... | [
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PMID:28899 | Cytoplasmic gamma-glutamyltransferase: isolation, product formation and physiological role. | These results establish the existence of a cytoplasmic glutaminase-gamma-glutamyltransferase enzyme as a distinct entity. Its products are ammonia and activated glutamate. Ammonia liberation is obligatory to the utilization of the amide bond energy in forming gamma-glutamyl-PO4. This activated glutamate can then be uti... | Cytoplasmic gamma-glutamyltransferase: isolation, product formation and physiological role. These results establish the existence of a cytoplasmic glutaminase-gamma-glutamyltransferase enzyme as a distinct entity. Its products are ammonia and activated glutamate. Ammonia liberation is obligatory to the utilization of t... | [
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PMID:28902 | alpha-Ketoglutarate regulation of glutamine transport and deamidation in renal mitochondria. | alpha-Ketoglutarate (KG) is a potent inhibitor of renal mitochondrial glutamine transport and deamidation at physiological concentrations. The concentration-inhibition relationship observed between KG and mitochondrial glutamine transport and deamidation indicates that changes in renal KG concentration occurring during... | alpha-Ketoglutarate regulation of glutamine transport and deamidation in renal mitochondria. alpha-Ketoglutarate (KG) is a potent inhibitor of renal mitochondrial glutamine transport and deamidation at physiological concentrations. The concentration-inhibition relationship observed between KG and mitochondrial glutamin... | [
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PMID:28906 | Neuropharmacological aspects of the neural control of prolactin secretion. | The use of neuropharmacological agents in neuroendocrine studies has had a significant impact on our knowledge about the neurotransmitter systems that are involved in the control of prolactin secretion. Selective drugs have played a key role in the identification of the dopaminergic inhibitory and serotonergic stimulat... | Neuropharmacological aspects of the neural control of prolactin secretion. The use of neuropharmacological agents in neuroendocrine studies has had a significant impact on our knowledge about the neurotransmitter systems that are involved in the control of prolactin secretion. Selective drugs have played a key role in ... | [
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PMID:28903 | Effects of maleate on CoA metabolism in rat kidney. | CoA transfer from acetoacetyl-CoA to maleate catalyzed by purified CoA transferase was studied. The thioester product of the reaction undergoes further chemical transformations and the final product appeared to be stable CoA derivative showing neither free SH group nor hydrolyzable thio-acyl bond. Similar product was o... | Effects of maleate on CoA metabolism in rat kidney. CoA transfer from acetoacetyl-CoA to maleate catalyzed by purified CoA transferase was studied. The thioester product of the reaction undergoes further chemical transformations and the final product appeared to be stable CoA derivative showing neither free SH group no... | [
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PMID:28904 | Metabolic changes induced by acute phosphate loading in acutely thyroparathyroidectomized rats. | Phosphate loading in acutely thyroparathyroidectomized rats is followed by a decline of phosphate reabsorption. In addition, a mixed respiratory and metabolic alkalosis and hypocalcemia develop. Normalization of plasma calcium concentration, unlike the reversal of the alkalosis, prevents the fall in phosphate reabsorpt... | Metabolic changes induced by acute phosphate loading in acutely thyroparathyroidectomized rats. Phosphate loading in acutely thyroparathyroidectomized rats is followed by a decline of phosphate reabsorption. In addition, a mixed respiratory and metabolic alkalosis and hypocalcemia develop. Normalization of plasma calci... | [
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PMID:28905 | Biochemical, immunological and ultrastructural studies on brush-border membranes of human kidney. | Brush border (BB) membranes, isolated from human kidney cortex by density gradient centrifugation, revealed a distinct pattern of structural proteins as could be shown by bio- and immunochemical studies. Marker enzymes such as gamma-glutamyltranspeptidase (GGTP) and alanine-aminopeptidase (AAP) were characterized as ex... | Biochemical, immunological and ultrastructural studies on brush-border membranes of human kidney. Brush border (BB) membranes, isolated from human kidney cortex by density gradient centrifugation, revealed a distinct pattern of structural proteins as could be shown by bio- and immunochemical studies. Marker enzymes suc... | [
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PMID:28913 | [Successful therapy of a severe dextran incident using histamin H1- and H2-receptor blockaders]. | A case of a severe systemic anaphylactoid reaction is reported in a patient treated with dextran 60 to prevent venous thrombosis. Significant improvement of clinical symptoms occurred after the usual treatment of such incidents with corticosteroids, histamine H1 receptor antagonists, and plasma substitutes was suppleme... | [Successful therapy of a severe dextran incident using histamin H1- and H2-receptor blockaders]. A case of a severe systemic anaphylactoid reaction is reported in a patient treated with dextran 60 to prevent venous thrombosis. Significant improvement of clinical symptoms occurred after the usual treatment of such incid... | [
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PMID:28915 | The biotransformation of p-xylene to a toxic aldehyde. | Rats given a single ip injection of p-xylene suffered 65% loss of pulmonary microsomal p-xylene hydroxylase activity. The activity was protected by pretreating the rats with phenobarbital, which increased hepatic p-xylene hydroxylase and cytosolic aldehyde dehydrogenase activities, but had no effect on alcohol dehydrog... | The biotransformation of p-xylene to a toxic aldehyde. Rats given a single ip injection of p-xylene suffered 65% loss of pulmonary microsomal p-xylene hydroxylase activity. The activity was protected by pretreating the rats with phenobarbital, which increased hepatic p-xylene hydroxylase and cytosolic aldehyde dehydrog... | [
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PMID:28916 | Microsomal metabolism of cyclohexene. Hydroxylation in the allylic position. | Hydroxylation of cyclohexene at the allylic position has been shown to occur in hepatic microsomes and 9000 g supernatant fractions of rats and rabbits. The formation of the product, 2-cyclohexen-1-ol, requires the presence of a NADPH-generating system, is inhibited by CO, metyrapone, and SKF 525-A, and is induced by p... | Microsomal metabolism of cyclohexene. Hydroxylation in the allylic position. Hydroxylation of cyclohexene at the allylic position has been shown to occur in hepatic microsomes and 9000 g supernatant fractions of rats and rabbits. The formation of the product, 2-cyclohexen-1-ol, requires the presence of a NADPH-generati... | [
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PMID:28918 | Synthesis and characterization of glucuronides of 5'-hydroxy-delta9-tetrahydrocannabinol and 11-hydroxy-delta9-tetrahydrocannabinol. | Glucuronides of two metabolites of delta9-tetrahydrocannabinol, 11-hydroxy-delta9-THC and 5'-hydroxy-delta9-THC, have been synthesized and characterized. Two isomeric monoglucuronides were isolated from the incubation of each metabolite with UDP-glucuronyltransferase immobilized on beaded Sepharose. The structures of t... | Synthesis and characterization of glucuronides of 5'-hydroxy-delta9-tetrahydrocannabinol and 11-hydroxy-delta9-tetrahydrocannabinol. Glucuronides of two metabolites of delta9-tetrahydrocannabinol, 11-hydroxy-delta9-THC and 5'-hydroxy-delta9-THC, have been synthesized and characterized. Two isomeric monoglucuronides wer... | [
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PMID:28919 | In vitro metabolism of phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone by rabbit liver preparations. | Phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone were incubated with rabbit liver 9000g supernatant fraction for 30 and 60 min to yield primarily the alcohols, plus small amounts of 1,2-glycols and ketols (2-one-1-ols). Phenylacetone incubations produced small amounts of benzoic acid, which was confir... | In vitro metabolism of phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone by rabbit liver preparations. Phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone were incubated with rabbit liver 9000g supernatant fraction for 30 and 60 min to yield primarily the alcohols, plus small amounts of ... | [
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PMID:28920 | Reductive metabolism of nitrofurantoin in the rat. | The reductive metabolism of nitrofurantoin under anaerobic conditions was characterized in various tissues from control, germ-free, and germ-free acclimatized rats. Nitrofurantoin metabolism was highest in homogenates of cecum and colon contents of germ-free acclimatized and control rats, but was absent from those of g... | Reductive metabolism of nitrofurantoin in the rat. The reductive metabolism of nitrofurantoin under anaerobic conditions was characterized in various tissues from control, germ-free, and germ-free acclimatized rats. Nitrofurantoin metabolism was highest in homogenates of cecum and colon contents of germ-free acclimatiz... | [
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PMID:28921 | Differential effects of Walker 256 carcinosarcoma cells growing subcutaneously, intramuscularly, or intraperitoneally on hepatic microsomal mixed-function oxygenase activity. | Walker 256 rat carcinosarcoma cells growing as solid subcutaneous or intramuscular tumors depressed hepatic microsomal mixed-function oxygenase activity to less than 20% of control activity, but the same tumor cells growing as free ascites cells in the peritoneal cavity did not. Necrosis of the core area of solid tumor... | Differential effects of Walker 256 carcinosarcoma cells growing subcutaneously, intramuscularly, or intraperitoneally on hepatic microsomal mixed-function oxygenase activity. Walker 256 rat carcinosarcoma cells growing as solid subcutaneous or intramuscular tumors depressed hepatic microsomal mixed-function oxygenase a... | [
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PMID:28922 | The fate of a major biliary metabolite of digitoxin in the rat intestine. | In the rat, the major water-soluble biliary metabolite of digotoxin is digitoxigenin monodigitoxoside glucuronide (mono-gluc). Despite its preponderance in the bile, only small amounts of mono-gluc are found in the feces. The compound may be absorbed from the intestine as the glucuronide conjugate, or it may be hydroly... | The fate of a major biliary metabolite of digitoxin in the rat intestine. In the rat, the major water-soluble biliary metabolite of digotoxin is digitoxigenin monodigitoxoside glucuronide (mono-gluc). Despite its preponderance in the bile, only small amounts of mono-gluc are found in the feces. The compound may be abso... | [
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PMID:28923 | Metabolism of benzo[a]pyrene by the isolated perfused rabbit lung. | The metabolism of benzo[a]pyrene (BP) was studied in the isolated perfused rabbit lung and in rabbit pulmonary microsomes. Pretreatment of rabbits with 3-methylcholanthrene did not increase the metabolism of BP by microsomal preparations, and the pretreatment did not induce cytochrome P-448 in pulmonary microsomes. In ... | Metabolism of benzo[a]pyrene by the isolated perfused rabbit lung. The metabolism of benzo[a]pyrene (BP) was studied in the isolated perfused rabbit lung and in rabbit pulmonary microsomes. Pretreatment of rabbits with 3-methylcholanthrene did not increase the metabolism of BP by microsomal preparations, and the pretre... | [
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PMID:28924 | Binding of iophenoxate and iopanoate to human serum albumin. | Determination of the binding affinities of 125I-labeled cholecystographic agents to human serum albumin by ultrafiltration techniques is complicated by the appearance of radiochemical impurities resulting from radiolysis of the parent compound. With labeled compounds purified daily by two extractions through chloroform... | Binding of iophenoxate and iopanoate to human serum albumin. Determination of the binding affinities of 125I-labeled cholecystographic agents to human serum albumin by ultrafiltration techniques is complicated by the appearance of radiochemical impurities resulting from radiolysis of the parent compound. With labeled c... | [
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... |
PMID:28925 | Competition for binding to multiple sites of human serum albumin for cholecystographic agents and sulfobromophthalein. | The binding of two cholecystographic agents, iophenoxate and iopanoate, to human serum albumin was studied with 11 putative competitors; the results were qualitatively consistent with competitive binding to common sites. A more precise analysis of competition was achieved with four pairs of compounds for which the free... | Competition for binding to multiple sites of human serum albumin for cholecystographic agents and sulfobromophthalein. The binding of two cholecystographic agents, iophenoxate and iopanoate, to human serum albumin was studied with 11 putative competitors; the results were qualitatively consistent with competitive bindi... | [
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PMID:28926 | Prolonged impairment of the plasma-protein binding of phenytoin in the rat after a single dose of sodium oleate. | The plasma-protein binding of phenytoin in rats was impaired for more than 14 days after a single injection of sodium oleate compared to that observed in saline-treated controls. A maximum free (unbound) phenytoin fraction value of about 0.30 was found between 30 and 120 min after oleate administration. The free fracti... | Prolonged impairment of the plasma-protein binding of phenytoin in the rat after a single dose of sodium oleate. The plasma-protein binding of phenytoin in rats was impaired for more than 14 days after a single injection of sodium oleate compared to that observed in saline-treated controls. A maximum free (unbound) phe... | [
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PMID:28928 | Disposition of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin) in beagle dogs and rhesus monkeys. | Following intragastric doses of 14C-oxaprozin to beagle dogs and rhesus monkeys, oxaprozin was rapidly absorbed and was essentially the only drug-related substance in the plasma for at least 24 hr. Recovery of radioactivity in the excreta was 87% in both species, with the fecal route accounting for almost all of the ex... | Disposition of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin) in beagle dogs and rhesus monkeys. Following intragastric doses of 14C-oxaprozin to beagle dogs and rhesus monkeys, oxaprozin was rapidly absorbed and was essentially the only drug-related substance in the plasma for at least 24 hr. Recovery of radioactivi... | [
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PMID:28929 | The fate of [7-3H]isoproterenol in cats after intravenous administration. | The fate of intravenously administered [7-3H]isoproterenol was investigated in cats. Ten minutes after injection the concentration of 3H was highest in the heart, lungs, adrenals, and kidneys, but after 5 hr most of the radioactivity was found in the liver. The concentration of the unchanged drug in the serum declined ... | The fate of [7-3H]isoproterenol in cats after intravenous administration. The fate of intravenously administered [7-3H]isoproterenol was investigated in cats. Ten minutes after injection the concentration of 3H was highest in the heart, lungs, adrenals, and kidneys, but after 5 hr most of the radioactivity was found in... | [
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PMID:28930 | O-methylated catechol-like metabolites of propranolol in man. | Two isomeric methoxyhydroxy metabolites of propranolol have been identified in man during chronic antihypertensive propranolol therapy. The identification was based on the mass-spectral fragmentation pattern of their trifluoroacetylated derivatives. Both isomers were detected in urine as well as in plasma, mainly as gl... | O-methylated catechol-like metabolites of propranolol in man. Two isomeric methoxyhydroxy metabolites of propranolol have been identified in man during chronic antihypertensive propranolol therapy. The identification was based on the mass-spectral fragmentation pattern of their trifluoroacetylated derivatives. Both iso... | [
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PMID:28931 | Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. | The metabolism of hydrocodone was studied in man, rat, guinea pig, rabbit, and dog. Routes of metabolism included O-demethylation, N-dealkylation, and 6-keto-reduction to the corresponding 6-alpha- and 6-beta-hydroxy metabolites, where each metabolic pathway produces an active metabolite. Mean total recovery of drug an... | Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. The metabolism of hydrocodone was studied in man, rat, guinea pig, rabbit, and dog. Routes of metabolism included O-demethylation, N-dealkylation, and 6-keto-reduction to the corresponding 6-alpha- and 6-beta-hydroxy metabolites, where each... | [
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PMID:28936 | [The effect of etilefrine and dihydroergotamine on sympathetic nervous system activity when standing up (author's transl)]. | Systolic blood pressure, heart rate and concentrations of adrenaline, noradrenaline and dopamine as well as plasma dopamine-beta-hydroxylase (DBH) were measured in 22 subjects in recumbency and on standing up. Six subjects each had previously been given intravenously dihydroergotamine (0.5 mg) or etilefrine (0.25 mg/mi... | [The effect of etilefrine and dihydroergotamine on sympathetic nervous system activity when standing up (author's transl)]. Systolic blood pressure, heart rate and concentrations of adrenaline, noradrenaline and dopamine as well as plasma dopamine-beta-hydroxylase (DBH) were measured in 22 subjects in recumbency and on... | [
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PMID:28932 | Characterization of glucuronide metabolites of carbamazepine in human urine by gas chromatography and mass spectrometry. | Glucuronide metabolites of carbamazepine (5 H-dibenz[b,f]azepine-5-carboxamide) were identified in human urine following chromatography on XAD-2 resin, permethylation, and combined gas chromatography and mass spectrometry with an SE-30 capillary column. Eight glucuronide metabolites, previously unidentified in man, wer... | Characterization of glucuronide metabolites of carbamazepine in human urine by gas chromatography and mass spectrometry. Glucuronide metabolites of carbamazepine (5 H-dibenz[b,f]azepine-5-carboxamide) were identified in human urine following chromatography on XAD-2 resin, permethylation, and combined gas chromatography... | [
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PMID:28939 | [Comparative trials on sultopride and fluanisone]. | A therapeutic trial has been carried out on 50 patients, most of them being hospitalized, in order to compare the characteristics of a new benzamide, Sultopride, to those of a butyrophenone, Fluanisone, for the treatment of important and chronic agitation states. Clinically, they were essentially psychotic states, with... | [Comparative trials on sultopride and fluanisone]. A therapeutic trial has been carried out on 50 patients, most of them being hospitalized, in order to compare the characteristics of a new benzamide, Sultopride, to those of a butyrophenone, Fluanisone, for the treatment of important and chronic agitation states. Clini... | [
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PMID:28940 | [Mental complications of neuroleptic drugs. Confusional oneiric states]. | The author reports five cases of relatively young women, in good general health, except that one of them had alcoholic liver disease, who presented a confusional state on taking neuroleptics: a widely used butyrophenone, prescribed for a psychotic condition. Owing to the low incidence of this side effect, these clinica... | [Mental complications of neuroleptic drugs. Confusional oneiric states]. The author reports five cases of relatively young women, in good general health, except that one of them had alcoholic liver disease, who presented a confusional state on taking neuroleptics: a widely used butyrophenone, prescribed for a psychotic... | [
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PMID:28941 | beta-adrenergic blocking drugs in psychiatry: present status, future approaches and research. | Clinical trials with propranolol were performed in 44 carefully selected psychiatric patients. Propranolol was administered in 8 equal doses over 24 hours and increased at a daily rate of 400 mg. Treatment was monitored by patient's reactions and by periodic examination of pulse rate and blood pressure. Results showed ... | beta-adrenergic blocking drugs in psychiatry: present status, future approaches and research. Clinical trials with propranolol were performed in 44 carefully selected psychiatric patients. Propranolol was administered in 8 equal doses over 24 hours and increased at a daily rate of 400 mg. Treatment was monitored by pat... | [
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PMID:28945 | Alkylation of 6-phosphogluconate dehydrogenase from Candida utilis with coenzyme analogues. | The mechanism of the inactivation of 6-phosphogluconate dehydrogenase from Candida utilis with two coenzyme analogues can be differentiated on the basis of kinetic studies and of the properties of the inactivated enzyme. 3-Chloroacetylpyridine--adenine dinucleotide phosphate is clearly an affinity label and 3-choloroac... | Alkylation of 6-phosphogluconate dehydrogenase from Candida utilis with coenzyme analogues. The mechanism of the inactivation of 6-phosphogluconate dehydrogenase from Candida utilis with two coenzyme analogues can be differentiated on the basis of kinetic studies and of the properties of the inactivated enzyme. 3-Chlor... | [
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PMID:28946 | Cryoenzymologic studies on arginine kinase: solvent, temperature and pH effects on the overall reaction. | The overall reaction catalyzed by the phosphotransferase arginine kinase was studied at normal and subzero temperatures. Ethylene glycol was used as the antifreeze and its effects on the Km values of substances, kcat and pH profiles were investigated in detail. a) The Km values for the substrate (2 mM for ATP and 0.6 m... | Cryoenzymologic studies on arginine kinase: solvent, temperature and pH effects on the overall reaction. The overall reaction catalyzed by the phosphotransferase arginine kinase was studied at normal and subzero temperatures. Ethylene glycol was used as the antifreeze and its effects on the Km values of substances, kca... | [
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PMID:28947 | Production of NADPH in the mannitol cycle and its relation to polyketide formation in Alternaria alternata. | The enzymes mannitol-1-phosphate dehydrogenase, mannitol-1-phosphatase, mannitol dehydrogenase and hexokinase participate in an enzymatic cycle in the fungus Alternaria alternata. One turn of the cycle gives the net result: NADH + NADP+ + ATP leads to NAD+ + NADPH + ADP + Pi. The cycle alone can meet the total need of ... | Production of NADPH in the mannitol cycle and its relation to polyketide formation in Alternaria alternata. The enzymes mannitol-1-phosphate dehydrogenase, mannitol-1-phosphatase, mannitol dehydrogenase and hexokinase participate in an enzymatic cycle in the fungus Alternaria alternata. One turn of the cycle gives the ... | [
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PMID:28948 | Factors modifying equilibrium between activated and non-activated forms of steroid-receptor complexes. | Steroid-receptor complexes formed in concentrated cytosol at low temperature, low ionic strength and neutral pH are unable to bind to nuclei. Various procedures are known to promote their 'activation'. In the present work it is shown that an increase in temperature only enhances the rate of the reaction whereas no chan... | Factors modifying equilibrium between activated and non-activated forms of steroid-receptor complexes. Steroid-receptor complexes formed in concentrated cytosol at low temperature, low ionic strength and neutral pH are unable to bind to nuclei. Various procedures are known to promote their 'activation'. In the present ... | [
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PMID:28952 | Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential hypertension: the influence of dietary sodium restriction. | To investigate the initial potassium loss and development of hypokalaemia during the administration of an oral diuretic, metabolic balance studies were performed in ten patients with essential hypertension who had shown hypokalaemia under prior oral diuretic treatment. Chlorthalidone (50 mg daily) was given for 14 days... | Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential hypertension: the influence of dietary sodium restriction. To investigate the initial potassium loss and development of hypokalaemia during the administration of an oral diuretic, metabolic balance studies were perfo... | [
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PMID:28954 | alpha- and beta-receptor blockade of isoproterenol- and norepinephrine-induced effects on regional blood flow and blood flow acceleration. | The effects of the beta-receptor blocking agent propranolol (100 microgram/kg i.v.) and of the alpha-receptor blocking agent dihydroergotamine (50 microgram/kg i.v.) on hemodynamic responses to isoproterenol and norepinephrine (both 1--1024 ng/kg) were investigated in anesthetized dogs. The effects studied were: (1) fl... | alpha- and beta-receptor blockade of isoproterenol- and norepinephrine-induced effects on regional blood flow and blood flow acceleration. The effects of the beta-receptor blocking agent propranolol (100 microgram/kg i.v.) and of the alpha-receptor blocking agent dihydroergotamine (50 microgram/kg i.v.) on hemodynamic ... | [
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PMID:28955 | The action of CNS drugs on an isolated sympathetic nerve preparation of rabbit. | The effect of some centrally active drugs on the transmission of nerve impulses through the isolated cervical sympathetic nerve and superior cervical ganglion of the rabbit has been studied by recording both preganglionic and ganglionic responses to single square wave stimuli. Chlorpromazine, trifluoperazine and halope... | The action of CNS drugs on an isolated sympathetic nerve preparation of rabbit. The effect of some centrally active drugs on the transmission of nerve impulses through the isolated cervical sympathetic nerve and superior cervical ganglion of the rabbit has been studied by recording both preganglionic and ganglionic res... | [
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PMID:28959 | Micro-electrophoretic studies in the cat pulvinar region: effect of acetylcholine. | 1. In the posterior half of the pulvinar of cats anaesthetized with halothane and nitrous oxide, the majority of neurons were fired by ACh released with small electrophoretic currents. In the anterior part of that nucleus, ACh had more variable effects: excitation, depression or none. 2. In comparison with L-glutamate,... | Micro-electrophoretic studies in the cat pulvinar region: effect of acetylcholine. 1. In the posterior half of the pulvinar of cats anaesthetized with halothane and nitrous oxide, the majority of neurons were fired by ACh released with small electrophoretic currents. In the anterior part of that nucleus, ACh had more v... | [
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PMID:28960 | Response characteristics of semicircular canal and otolith systems in cat. I. Dynamic responses of primary vestibular fibers. | 1. The activity of cat semicircular canal and otolith afferents was studied during yaw and roll rotations, respectively, to examine their dynamic behavior. 2. A sinusoidal analysis of the canal afferent activities showed that their dynamic characteristics are similar to those of second order vestibular neurons, except ... | Response characteristics of semicircular canal and otolith systems in cat. I. Dynamic responses of primary vestibular fibers. 1. The activity of cat semicircular canal and otolith afferents was studied during yaw and roll rotations, respectively, to examine their dynamic behavior. 2. A sinusoidal analysis of the canal ... | [
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PMID:28961 | Biochemical and anatomical adaptation of the lung to oxygen-induced injury. | A review of anatomical and biochemical responses of the lung to high concentrations of oxygen leads us to postulate a biphasic adaptive response. The early phase entails a defense against life-threatening pulmonary edema engendered by destruction of oxygen susceptible cells forming most of the air-blood interface. This... | Biochemical and anatomical adaptation of the lung to oxygen-induced injury. A review of anatomical and biochemical responses of the lung to high concentrations of oxygen leads us to postulate a biphasic adaptive response. The early phase entails a defense against life-threatening pulmonary edema engendered by destructi... | [
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PMID:28965 | Hemolytic assay of complement and its components from Syrian hamster (Mesocricetus auratus) and Mongolian gerbil (Mariones unguiculatus). | Syrian hamster sera may be assayed for hemolytic complement (C) activity by standard procedures with sensitized sheep erythrocytes as used for human sera, but mongolian gerbil sera had higher complement titers when tested with sensitized guinea pig erythrocytes as target cells. The optimal conditions for in vitro testi... | Hemolytic assay of complement and its components from Syrian hamster (Mesocricetus auratus) and Mongolian gerbil (Mariones unguiculatus). Syrian hamster sera may be assayed for hemolytic complement (C) activity by standard procedures with sensitized sheep erythrocytes as used for human sera, but mongolian gerbil sera h... | [
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PMID:28968 | Benign hydatidiform mole in Ibadan, Nigeria. | A study was conducted to analyze 61 patients with benign hydatidiform mole (HM) who were admitted to the University College Hospital in Ibadan, Nigeria, during a 5-year period. The hospital incidence of HM was 1:205 pregnancies, and the condition was seen most commonly in young women, probably because early marriage is... | Benign hydatidiform mole in Ibadan, Nigeria. A study was conducted to analyze 61 patients with benign hydatidiform mole (HM) who were admitted to the University College Hospital in Ibadan, Nigeria, during a 5-year period. The hospital incidence of HM was 1:205 pregnancies, and the condition was seen most commonly in yo... | [
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PMID:28969 | Hydatidiform mole in southern Iran: a statistical survey of 113 cases. | A statistical review of 113 cases of hydatidiform mole (HM) seen at Pahlavi University Hospital from January 1970 to December 1975 is presented. The incidence of the disease was found to be 1:314 pregnancies. In this study, 73.5% of the patients presumably had acceptable socioeconomic circumstances. The highest inciden... | Hydatidiform mole in southern Iran: a statistical survey of 113 cases. A statistical review of 113 cases of hydatidiform mole (HM) seen at Pahlavi University Hospital from January 1970 to December 1975 is presented. The incidence of the disease was found to be 1:314 pregnancies. In this study, 73.5% of the patients pre... | [
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PMID:28970 | High frequency of hydatidiform mole in native Alaskans. | The frequency of hydatidiform mole per delivery in the native Alaskan for fiscal years 1969 through 1974 was 1:257. Nutritional studies do not support the suggestion of protein deficiency as an etiologic factor. It is suggested that genetic factors may be involved. | High frequency of hydatidiform mole in native Alaskans. The frequency of hydatidiform mole per delivery in the native Alaskan for fiscal years 1969 through 1974 was 1:257. Nutritional studies do not support the suggestion of protein deficiency as an etiologic factor. It is suggested that genetic factors may be involved... | [
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PMID:28971 | Myomectomy in infertile Jamaican women. | One hundred nineteen Jamaican women who underwent myomectomy from 1964 to 1969 were followed up for 5 to 9 years. Infertility was the most common presenting complaint. Preoperative hysterosalpingograms were performed on 61 patients and were abnormal for the majority of these patients. Surgery revealed submucous fibroid... | Myomectomy in infertile Jamaican women. One hundred nineteen Jamaican women who underwent myomectomy from 1964 to 1969 were followed up for 5 to 9 years. Infertility was the most common presenting complaint. Preoperative hysterosalpingograms were performed on 61 patients and were abnormal for the majority of these pati... | [
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PMID:28972 | Unification of a septate uterus: Mahgoub's operation. | A simple surgical technique for unification of a septate uterus is described. The septum and a small strip of fundus are removed with scissors inserted through two small fundal stabs, and the opening is closed with one mattress suture, which forms an anteroposterior suture line no more than 1 cm long. At the end of the... | Unification of a septate uterus: Mahgoub's operation. A simple surgical technique for unification of a septate uterus is described. The septum and a small strip of fundus are removed with scissors inserted through two small fundal stabs, and the opening is closed with one mattress suture, which forms an anteroposterior... | [
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PMID:28973 | Rupture of the uterus. | Sixty-four cases of rupture of the uterus were managed from March 1967 to March 1977. The maternal morbidity was 81.0%, and there were six maternal deaths (9.4%). Fifty-two patients (85.5%) had hysterectomies. The average hospital stay for patients who survived was 15.5 days. The fetal mortality rate was 89%. The etiol... | Rupture of the uterus. Sixty-four cases of rupture of the uterus were managed from March 1967 to March 1977. The maternal morbidity was 81.0%, and there were six maternal deaths (9.4%). Fifty-two patients (85.5%) had hysterectomies. The average hospital stay for patients who survived was 15.5 days. The fetal mortality ... | [
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PMID:28974 | The present and future of immunologic approaches to contraception. | A vaccine capable of causing active immunity against one or more key elements of conception would have several advantages over currently available methods of fertility regulation. It would be amenable to mass use, would require only periodic follow-up, and would not require continuous user motivation. Although natural ... | The present and future of immunologic approaches to contraception. A vaccine capable of causing active immunity against one or more key elements of conception would have several advantages over currently available methods of fertility regulation. It would be amenable to mass use, would require only periodic follow-up, ... | [
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PMID:28975 | Inducing labor with oral prostaglandin E2 tablets. | Labor was successfully induced by forewater amniotomy and oral administration of prostaglandin E2 tablets in 91.3% of 153 women with singleton pregnancies. Deliveries occurred within 12 hours for more than 90% of the successfully induced patients. Although not statistically significant, a higher pelvic score appeared t... | Inducing labor with oral prostaglandin E2 tablets. Labor was successfully induced by forewater amniotomy and oral administration of prostaglandin E2 tablets in 91.3% of 153 women with singleton pregnancies. Deliveries occurred within 12 hours for more than 90% of the successfully induced patients. Although not statisti... | [
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PMID:28976 | Preoperative cervical dilatation with 15(S)15-methyl PGF2alpha methyl ester pessaries. | A clinical trial comparing two vaginal dose schedules of 15(S)15-methyl prostaglandin F2alpha (PGF2alpha) methyl ester (4 or 6 mg) for preoperative dilatation of the cervix is described. The trial included 28 patients at 8-12 weeks' gestation. Vaginal pessaries containing either 1.0 mg (15 patients) or 1.5 mg (13 patie... | Preoperative cervical dilatation with 15(S)15-methyl PGF2alpha methyl ester pessaries. A clinical trial comparing two vaginal dose schedules of 15(S)15-methyl prostaglandin F2alpha (PGF2alpha) methyl ester (4 or 6 mg) for preoperative dilatation of the cervix is described. The trial included 28 patients at 8-12 weeks' ... | [
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PMID:28977 | Menstrual regulation in Ibadan, Nigeria. | Menstrual regulation (MR) (i.e., vacuum aspiration of the uterus with a small diameter, flexible cannula before pregnancy can be determined by a conventional pregnancy test) has been proven safe and effective in many clinics around the world. The present study, which we believe is the first such study of MR in Subsahar... | Menstrual regulation in Ibadan, Nigeria. Menstrual regulation (MR) (i.e., vacuum aspiration of the uterus with a small diameter, flexible cannula before pregnancy can be determined by a conventional pregnancy test) has been proven safe and effective in many clinics around the world. The present study, which we believe ... | [
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PMID:28978 | A comparison of metal and plastic cannulae for vacuum aspiration. | A comparative study of the safety and effectiveness of metal (Purandare) versus plastic (Karman) cannulae for first trimester abortion was conducted on 400 women. Two hundred vacuum aspiration procedures were performed using each type of cannula. All aspirations were performed by a single physician, and patient follow-... | A comparison of metal and plastic cannulae for vacuum aspiration. A comparative study of the safety and effectiveness of metal (Purandare) versus plastic (Karman) cannulae for first trimester abortion was conducted on 400 women. Two hundred vacuum aspiration procedures were performed using each type of cannula. All asp... | [
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PMID:28979 | Second trimester abortion with 5% intraamniotic saline--a pilot study. | The risk of hypernatremia and related postabortion complications resulting from the intraamniotic administration of a 20-25% hypertonic saline solution, a widely used procedure all over the world, prompted this trial of 5% saline. Midtrimester abortion was induced in 150 women with a 5% saline solution administered int... | Second trimester abortion with 5% intraamniotic saline--a pilot study. The risk of hypernatremia and related postabortion complications resulting from the intraamniotic administration of a 20-25% hypertonic saline solution, a widely used procedure all over the world, prompted this trial of 5% saline. Midtrimester abort... | [
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PMID:28980 | Hospital counseling in Khartoum: a study of factors affecting contraceptive acceptance after abortion. | This study examines the impact of contraceptive counseling on 3 263 women hospitalized in Khartoum for treatment of incomplete abortion. The analysis which focused on education and parity/child desire, revealed that the counseling program produced contraceptive acceptance among 47.0% of those followed up. In spite of t... | Hospital counseling in Khartoum: a study of factors affecting contraceptive acceptance after abortion. This study examines the impact of contraceptive counseling on 3 263 women hospitalized in Khartoum for treatment of incomplete abortion. The analysis which focused on education and parity/child desire, revealed that t... | [
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PMID:28981 | Advances in sterilization equipment. | From the array of sterilization procedures that are safe, simple and effective, the service provider must select procedures that fit his or her logistical criteria, which include the cost and maintenance of equipment, availability of supplies, and training of the requisite personnel. In this paper, these criteria are d... | Advances in sterilization equipment. From the array of sterilization procedures that are safe, simple and effective, the service provider must select procedures that fit his or her logistical criteria, which include the cost and maintenance of equipment, availability of supplies, and training of the requisite personnel... | [
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PMID:28982 | Laparoscopic electrocoagulation and tubal ring techniques for sterilization: a comparative study. | From August 1975 through May 1976, a comparative study was made of the effects of sterilization by standard electrocoagulation and tubal ring application techniques. The two techniques were randomly assigned to 300 patients. Results show that standard electrocoagulation and tubal ring procedures can easily and safely b... | Laparoscopic electrocoagulation and tubal ring techniques for sterilization: a comparative study. From August 1975 through May 1976, a comparative study was made of the effects of sterilization by standard electrocoagulation and tubal ring application techniques. The two techniques were randomly assigned to 300 patient... | [
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PMID:28983 | Training physicians of developing nations in female surgical contraception. | The majority of developing nations in the Third World (including Thailand) face similar medicosocioeconomic situations arising from uncontrolled population growth which outstrips developmental planning. One of the most effective medical means of combating these problems is surgical contraception. This study describes h... | Training physicians of developing nations in female surgical contraception. The majority of developing nations in the Third World (including Thailand) face similar medicosocioeconomic situations arising from uncontrolled population growth which outstrips developmental planning. One of the most effective medical means o... | [
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PMID:28984 | The water and nitrogen composition of the placenta in anemic women. | A study was conducted to determine the water and nitrogen content of the placentae from anemic and nonanemic Nigerian women. The mean water content values were 84.9% and 85.3%, respectively, and this difference was not statistically significant. Placental nitrogen values were higher in anemic women than they were in no... | The water and nitrogen composition of the placenta in anemic women. A study was conducted to determine the water and nitrogen content of the placentae from anemic and nonanemic Nigerian women. The mean water content values were 84.9% and 85.3%, respectively, and this difference was not statistically significant. Placen... | [
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PMID:28986 | Effects of x-ray on a gravida with severe hemoconcentration: a case report. | A gravida with severe hemoconcentration was studied with intravenous urography because of right upper quadrant pain. She subsequently developed renal failure. The potential hazard of urography in the presence of a severe blood volume contraction state is noted. | Effects of x-ray on a gravida with severe hemoconcentration: a case report. A gravida with severe hemoconcentration was studied with intravenous urography because of right upper quadrant pain. She subsequently developed renal failure. The potential hazard of urography in the presence of a severe blood volume contractio... | [
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PMID:28987 | Coarctation of the umbilical cord: a cause of intrauterine fetal death. | This article presents 16 cases of coarctation of the umbilical cord, resulting in fetal death in utero in pregnant women of more than 6 months' gestation. Coarctation of the umbilical cord can occur in any phase of the gestational period and is not related to parity. The stricture of the cord is usually accompanied by ... | Coarctation of the umbilical cord: a cause of intrauterine fetal death. This article presents 16 cases of coarctation of the umbilical cord, resulting in fetal death in utero in pregnant women of more than 6 months' gestation. Coarctation of the umbilical cord can occur in any phase of the gestational period and is not... | [
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PMID:28988 | Controlled assessment of oral bronchodilators for asthmatic children. | Various pulmonary function changes were determined in twenty paediatric patients after a single oral dose of theophylline, ephedrine, or their combination in a double-blind crossover study. The possible contributions of guaifenesin and butabarbital, components of some formulations in clinical use, were also examined. B... | Controlled assessment of oral bronchodilators for asthmatic children. Various pulmonary function changes were determined in twenty paediatric patients after a single oral dose of theophylline, ephedrine, or their combination in a double-blind crossover study. The possible contributions of guaifenesin and butabarbital, ... | [
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PMID:28989 | Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs. | The short-term hypnotic efficacy of triazolam was compared to that of flurazepam and placebo in 120 out-patient insomniacs. Each patient was studied with a two-night, double-blind crossover trial. Triazolam (0.5 mg) was compared to placebo and flurazepam (30 mg). Triazolam (0.25 mg) was compared to flurazepam (15 mg an... | Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs. The short-term hypnotic efficacy of triazolam was compared to that of flurazepam and placebo in 120 out-patient insomniacs. Each patient was studied with a two-night, double-blind crossover trial. Triazolam (0.5 mg) was compared to pl... | [
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PMID:28990 | A clinical comparison of triazolam with placebo and with secobarbital in insomniac patients. | Seventy-six out-patient insomniacs participated in three different two-night, double-blind crossover trials investigating the hypnotic efficacy andsafety of triazolam. Triazolam 0.5 mg was compared to placebo in one trial conducted K Kay Okawa, MD, and triazolam 0.5 mg was compared to secobarbital 100 mg in trials cond... | A clinical comparison of triazolam with placebo and with secobarbital in insomniac patients. Seventy-six out-patient insomniacs participated in three different two-night, double-blind crossover trials investigating the hypnotic efficacy andsafety of triazolam. Triazolam 0.5 mg was compared to placebo in one trial condu... | [
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PMID:28998 | Arbovirus isolations from mosquitoes in South Slovakia. | In the years 1973 and 1975 mosquitoes and some other Diptera (Tabanidae, Simuliidae, Hippoboscidae) were tested for virus. 13,924 mosquitoes, 75 horseflies and 60 blackflies were processed in 1973. Five strains of Tahyna virus were isolated from mosquito species Aedes vexans. 3,378 mosquitoes and 12 sheep keds were tes... | Arbovirus isolations from mosquitoes in South Slovakia. In the years 1973 and 1975 mosquitoes and some other Diptera (Tabanidae, Simuliidae, Hippoboscidae) were tested for virus. 13,924 mosquitoes, 75 horseflies and 60 blackflies were processed in 1973. Five strains of Tahyna virus were isolated from mosquito species A... | [
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PMID:29003 | Chinese health system gets down to basics. | Preventive medicine and primary health care, rather than advanced medical technology, appear to be the focus of health care delivery in China. In fact, the author says, one could imagine a decision being made not to install a CT scanner so that more physician extenders could be trained to improve nutritional standards,... | Chinese health system gets down to basics. Preventive medicine and primary health care, rather than advanced medical technology, appear to be the focus of health care delivery in China. In fact, the author says, one could imagine a decision being made not to install a CT scanner so that more physician extenders could b... | [
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PMID:29004 | Identification of a new serum protein polymorphism as transferrin. | By isoelectric focusing at pH 3.5--9.5, Kühnl and Spielmann (1977) recently demonstrated a new genetically determined serum protein polymorphism designated 'Hpa' because of an apparently specific reaction with antihaptoglobin. In this study the polymorphism was reproduced, but the components were found to focus at pH 5... | Identification of a new serum protein polymorphism as transferrin. By isoelectric focusing at pH 3.5--9.5, Kühnl and Spielmann (1977) recently demonstrated a new genetically determined serum protein polymorphism designated 'Hpa' because of an apparently specific reaction with antihaptoglobin. In this study the polymorp... | [
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PMID:29005 | Preparation and long-term cultivation of porcine tracheal and lung organ cultures by alternate exposure to gaseous and liquid medium phases. | Conventional methods of organ culture have proved unsatisfactory for mammalian lung because of the rapid collapse of the tissue and the loss of its normal structure. In an effort to circumvent this problem and to provide a means for visualizing the cellular relationships throughout the culture period, respiratory organ... | Preparation and long-term cultivation of porcine tracheal and lung organ cultures by alternate exposure to gaseous and liquid medium phases. Conventional methods of organ culture have proved unsatisfactory for mammalian lung because of the rapid collapse of the tissue and the loss of its normal structure. In an effort ... | [
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PMID:29007 | Adherence of Mycoplasma gallisepticum to human erythrocytes. | Pathogenic mycoplasmas adhere to and colonize the epithelial lining of the respiratory and genital tracts of infected animals. An experimental system suitable for the quantitative study of mycoplasma adherence has been developed by us. The system consists of human erythrocytes (RBC) and the avian pathogen Mycoplasma ga... | Adherence of Mycoplasma gallisepticum to human erythrocytes. Pathogenic mycoplasmas adhere to and colonize the epithelial lining of the respiratory and genital tracts of infected animals. An experimental system suitable for the quantitative study of mycoplasma adherence has been developed by us. The system consists of ... | [
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PMID:29008 | Increased susceptibility of splenectomized mice to infection after exposure to an aerosolized suspension of type III Streptococcus pneumoniae. | Most reported experimental studies concerning the effect of splenectomy in animals have shown enhanced mortality from pneumococci injected either intravenously or intraperitoneally. We have developed a laboratory model in which mice are exposed to type III Streptococcus pneumoniae via an aerosolized atmosphere, thus cl... | Increased susceptibility of splenectomized mice to infection after exposure to an aerosolized suspension of type III Streptococcus pneumoniae. Most reported experimental studies concerning the effect of splenectomy in animals have shown enhanced mortality from pneumococci injected either intravenously or intraperitonea... | [
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PMID:29009 | Respiration and oxidative phosphorylation in Treponema pallidum. | Exogenous and endogenously generated reduced pyridine nucleotides caused marked stimulation of O(2) uptake when added to treponemal cell-free extracts, which indicated that terminal electron transport was coupled to the consumption of O(2). Oxidation of reduced nicotinamide adenine dinucleotide (NADH) was shown to corr... | Respiration and oxidative phosphorylation in Treponema pallidum. Exogenous and endogenously generated reduced pyridine nucleotides caused marked stimulation of O(2) uptake when added to treponemal cell-free extracts, which indicated that terminal electron transport was coupled to the consumption of O(2). Oxidation of r... | [
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PMID:29015 | The application of covert conditioning procedures to the outpatient treatment of drug addicts: four case studies. | The purpose of this study was to determine the effectiveness of covert conditioning procedures in the outpatient treatment of drug addicts who wished to decrease or cease use of drugs. A desensitization design proved unsuccessful in reducing craving in an opiate user with a 2-year history of abuse. Three sensitization ... | The application of covert conditioning procedures to the outpatient treatment of drug addicts: four case studies. The purpose of this study was to determine the effectiveness of covert conditioning procedures in the outpatient treatment of drug addicts who wished to decrease or cease use of drugs. A desensitization des... | [
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PMID:29016 | A comparative study of three different citrate combinations of litholytic action. | Three different combinations--the Eisenberg solution, Uralyt-U and Magurlit--have been compared for their litholytic effect on urate calculi in a homogeneous patient material. Magurlit and Uralyt-U have been found superior to the Eisenberg solution, insofar as they are dispensed in a hygienic form easy to handle and re... | A comparative study of three different citrate combinations of litholytic action. Three different combinations--the Eisenberg solution, Uralyt-U and Magurlit--have been compared for their litholytic effect on urate calculi in a homogeneous patient material. Magurlit and Uralyt-U have been found superior to the Eisenber... | [
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PMID:29017 | Antibiotics excretion in canine vaginal and urethral secretions. | Trimethroprim, erythromycin, ampicillin, and rosamicin, a new macrolide antibiotic, were administered to dogs by constant intravenous infusion. Their concentrations in plasma, urine, vaginal and urethral secretions, saliva, and tears were determined by bioassay. Trimethoprim, rosamicin, and, to a lower degree, erythrom... | Antibiotics excretion in canine vaginal and urethral secretions. Trimethroprim, erythromycin, ampicillin, and rosamicin, a new macrolide antibiotic, were administered to dogs by constant intravenous infusion. Their concentrations in plasma, urine, vaginal and urethral secretions, saliva, and tears were determined by bi... | [
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0.003... |
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