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PMID:28666 | Digestive-absorptive function of the intestinal brush border in uremia. | Amino acid absorption was studied in chronic uremic rats. Intestinal transport of L-leucine appears to be inhibited with mild uremic intoxication, whereas severe uremia enhances absorption. Brush border activity of intestinal maltase and disaccharidases is higher in rats with chronic renal insufficiency. The same holds... | Digestive-absorptive function of the intestinal brush border in uremia. Amino acid absorption was studied in chronic uremic rats. Intestinal transport of L-leucine appears to be inhibited with mild uremic intoxication, whereas severe uremia enhances absorption. Brush border activity of intestinal maltase and disacchari... | [
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PMID:28667 | Ulcerative colitis in association with Takayasu's disease. | A case of total ulcerative colitis associated with large-vessel disease consistent with a diagnosis of Takayasu's disease is described in a 21-year-old Pakistani female. The possible relationship between the two disorders is discussed. | Ulcerative colitis in association with Takayasu's disease. A case of total ulcerative colitis associated with large-vessel disease consistent with a diagnosis of Takayasu's disease is described in a 21-year-old Pakistani female. The possible relationship between the two disorders is discussed. | [
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PMID:28670 | Persistent pulmonary hypertension in the neonate: development of an animal model. | Chronic intrauterine hypoxia was induced in third-trimester lamb fetuses by daily embolization of the maternal side of the placenta with nonradioactive microspheres. After delivery at term, the chronically hypoxic fetuses had significantly increased pulmonary artery pressures when compared to nonhypoxic control measure... | Persistent pulmonary hypertension in the neonate: development of an animal model. Chronic intrauterine hypoxia was induced in third-trimester lamb fetuses by daily embolization of the maternal side of the placenta with nonradioactive microspheres. After delivery at term, the chronically hypoxic fetuses had significantl... | [
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PMID:28671 | Evaluation of continuous monitoring of tissue pH in cats. | An improved continuous tissue pH monitoring system, designed for human subcutaneous fetal scalp tissue, was evaluated in 10 cats for total of 60 hours. Respiratory acidosis was induced with and without hypoxia to model the pathology of human clinical fetal distress. Arterial and venous pH were sampled every 15 minutes ... | Evaluation of continuous monitoring of tissue pH in cats. An improved continuous tissue pH monitoring system, designed for human subcutaneous fetal scalp tissue, was evaluated in 10 cats for total of 60 hours. Respiratory acidosis was induced with and without hypoxia to model the pathology of human clinical fetal distr... | [
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PMID:28672 | Effects of endotoxin on the pregnant baboon and fetus. | Effects of E. coli endotoxin upon uterine activity and maternal and fetal condition were studied in four pregnant baboons and their fetuses. Uterine activity increased significantly following administration of endotoxin to the mother. Endotoxin also produced maternal circulatory collapse, severe acidosis, and profound ... | Effects of endotoxin on the pregnant baboon and fetus. Effects of E. coli endotoxin upon uterine activity and maternal and fetal condition were studied in four pregnant baboons and their fetuses. Uterine activity increased significantly following administration of endotoxin to the mother. Endotoxin also produced matern... | [
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PMID:28673 | Electron microscopy of nephropathia epidemica. Renal tubular basement membrane. | Tubular basement membranes in kidney biopsies from 18 patients with nephropathia epidemica were studied by electron microscopy. Both in the cortex and in the medulla there was splitting of the basement membrane. Thickened basement membrane around occasional tubules contained membrane vesicles, usually empty but also wi... | Electron microscopy of nephropathia epidemica. Renal tubular basement membrane. Tubular basement membranes in kidney biopsies from 18 patients with nephropathia epidemica were studied by electron microscopy. Both in the cortex and in the medulla there was splitting of the basement membrane. Thickened basement membrane ... | [
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PMID:28674 | Demethylation in erythrocytes: a reaction involving hemoglobin. | A reaction is described in erythrocytes of rat and of man whereby O-methylated metabolites of the catecholamines are demethylated to the corresponding catechols. The reaction was studied by incubating aliquots of erythrocyte lysates with radiolabeled O-methylated compounds and isolating the catechol product by alumina ... | Demethylation in erythrocytes: a reaction involving hemoglobin. A reaction is described in erythrocytes of rat and of man whereby O-methylated metabolites of the catecholamines are demethylated to the corresponding catechols. The reaction was studied by incubating aliquots of erythrocyte lysates with radiolabeled O-met... | [
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PMID:28675 | H + transport in urinary epithelia. | This review of urinary acidification is primarily based on studies in isolated epithelia such as the turtle bladder. Despite the lack of unambiguous proof, the wealth of indirect evidence suggests that the cause of bicarbonate absorption is H+ secretion into the lumen. The mechanisms that regulate H+ transport are disc... | H + transport in urinary epithelia. This review of urinary acidification is primarily based on studies in isolated epithelia such as the turtle bladder. Despite the lack of unambiguous proof, the wealth of indirect evidence suggests that the cause of bicarbonate absorption is H+ secretion into the lumen. The mechanisms... | [
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PMID:28676 | Hemodynamic functions and blood viscosity in surface hypothermia. | Hemodynamic functions and blood viscosity changes in hypothermia (core approximately 25 degrees C) were studied in 14 pentobarbital-anesthetized dogs subjected to surface cooling. The viscosity of blood (eta B) increased progressively to 173% of that at 37 degrees C when body temperature was lowered to 25 degrees C. Th... | Hemodynamic functions and blood viscosity in surface hypothermia. Hemodynamic functions and blood viscosity changes in hypothermia (core approximately 25 degrees C) were studied in 14 pentobarbital-anesthetized dogs subjected to surface cooling. The viscosity of blood (eta B) increased progressively to 173% of that at ... | [
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PMID:28677 | Field survey of enteric viruses in solid waste landfill leachates. | Because municipal solid waste may contain fecal material from a variety of sources, there is concern that the leachate discharged from some solid waste landfills may contain enteric pathogens, including enteric viruses. In this study, 22 leachate samples from 21 different landfills in the United States and Canada were ... | Field survey of enteric viruses in solid waste landfill leachates. Because municipal solid waste may contain fecal material from a variety of sources, there is concern that the leachate discharged from some solid waste landfills may contain enteric pathogens, including enteric viruses. In this study, 22 leachate sample... | [
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PMID:28678 | The effect of pH on platelet and coagulation factor activities. | After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosi... | The effect of pH on platelet and coagulation factor activities. After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that c... | [
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PMID:28682 | Glutathione depletion following inhalation anesthesia. | Glutathione depletion following inhalation of halogenated anesthetics was investigated as a possible mechanism of toxic reactions associated with anesthesia. Concentrations of reduced glutathione were measured in the blood, liver, lung and kidney of the mouse after anesthesia with enflurane, fluroxene, halothane, isofl... | Glutathione depletion following inhalation anesthesia. Glutathione depletion following inhalation of halogenated anesthetics was investigated as a possible mechanism of toxic reactions associated with anesthesia. Concentrations of reduced glutathione were measured in the blood, liver, lung and kidney of the mouse after... | [
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PMID:28683 | Systemic arterial blood pH servocontrol of mechanical ventilation. | Servocontrol of mechanical ventilation using systemic arterial blood pH, measured by a dual-function pH/PCO2 intra-arterial sensor, as the controlled variable uas carried out in 30 dogs anesthetized with pentobarbital, 30 mg/kg. The control loop consisted of the animal, an intra-arterial dual-function pH/PCO2 sensor an... | Systemic arterial blood pH servocontrol of mechanical ventilation. Servocontrol of mechanical ventilation using systemic arterial blood pH, measured by a dual-function pH/PCO2 intra-arterial sensor, as the controlled variable uas carried out in 30 dogs anesthetized with pentobarbital, 30 mg/kg. The control loop consist... | [
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PMID:28684 | Inhibition of cutaneous and mucosal allergy with phenyltoloxamine. | A dose-and-time related-effect of oral phenyltoloxamine citrate, a Class I, H1 antihistamine compound, has been demonstrated against allergen-induced wheal-and-erythema skin reactions among 10 adults with a diagnosis of allergic rhinitis and seasonal pollinosis. Clinical improvement in the existing symptoms of rhinorrh... | Inhibition of cutaneous and mucosal allergy with phenyltoloxamine. A dose-and-time related-effect of oral phenyltoloxamine citrate, a Class I, H1 antihistamine compound, has been demonstrated against allergen-induced wheal-and-erythema skin reactions among 10 adults with a diagnosis of allergic rhinitis and seasonal po... | [
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PMID:28686 | Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam. | 20 mg of medazepam were taken by mouth by 9 healthy volunteers in an acute absorption study. About a 10-fold variation was found during the first 6 hours after the drug in individual serum medazepam, diazepam, and N-desmethyldiazepam levels. In a subacute study 10 mg of medazepam t.i.d. was given to 10 institutionalize... | Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam. 20 mg of medazepam were taken by mouth by 9 healthy volunteers in an acute absorption study. About a 10-fold variation was found during the first 6 hours after the drug in individual serum medazepam, diazepam, a... | [
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PMID:28687 | Effects of a new beta1-selective beta-blocker H 87/07 in angina pectoris. | The efficacy and toleration of a new beta1-selective beta-blocker, H 87/07, was compared with placebo in 33 patients with angina pectoris. The efficacy was evaluated using subjective assessments of attack rate and nitroglycerin consumption as well as objective assessments of exercise tolerance on a bicycle ergometer. H... | Effects of a new beta1-selective beta-blocker H 87/07 in angina pectoris. The efficacy and toleration of a new beta1-selective beta-blocker, H 87/07, was compared with placebo in 33 patients with angina pectoris. The efficacy was evaluated using subjective assessments of attack rate and nitroglycerin consumption as wel... | [
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PMID:28690 | Chloramphenicol acetyltransferase of Bacteroides fragilis. | Chloramphenicol-resistant strains of Bacteroides fragilis (minimum inhibitory concentration, 12.5 mug/ml) were isolated from a stool specimen which contained multiply resistant Escherichia coli. The enzyme responsible for resistance, chloramphenicol acetyltransferase, was produced constitutively by these strains; the s... | Chloramphenicol acetyltransferase of Bacteroides fragilis. Chloramphenicol-resistant strains of Bacteroides fragilis (minimum inhibitory concentration, 12.5 mug/ml) were isolated from a stool specimen which contained multiply resistant Escherichia coli. The enzyme responsible for resistance, chloramphenicol acetyltrans... | [
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PMID:28691 | Biological effects of 5-carboxy-2'-deoxyuridine: hydrolysis product of 5-trifluoromethyl-2'-deoxyuridine. | 5-Carboxy-2'-deoxyuridine (5-COOH-2'-dUrd) is a product of the base-catalyzed hydrolysis of 5-trifluoromethyl-2'-deoxyuridine. Hydrolysis of 5-trifluoromethyl-2'-deoxyuridine to 5-COOH-2'-dUrd in phosphate-buffered saline was kinetically first order and was pH dependent. At 37 degrees C and pH 7.0, 7.5, and 8.0, hydrol... | Biological effects of 5-carboxy-2'-deoxyuridine: hydrolysis product of 5-trifluoromethyl-2'-deoxyuridine. 5-Carboxy-2'-deoxyuridine (5-COOH-2'-dUrd) is a product of the base-catalyzed hydrolysis of 5-trifluoromethyl-2'-deoxyuridine. Hydrolysis of 5-trifluoromethyl-2'-deoxyuridine to 5-COOH-2'-dUrd in phosphate-buffered... | [
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PMID:28692 | Streptococcin A-FF22: nisin-like antibiotic substance produced by a group A streptococcus. | Streptococcin A-FF22 (SA) was shown to occur as both a cell-associated (SA-CA) and an extracellular (SA-EX) component of cultures of the producer bacterium, group A streptococcus strain FF22. SA-CA was solubilized by chemical, enzymatic, and mechanical procedures, similar to those used to release M protein. The indepen... | Streptococcin A-FF22: nisin-like antibiotic substance produced by a group A streptococcus. Streptococcin A-FF22 (SA) was shown to occur as both a cell-associated (SA-CA) and an extracellular (SA-EX) component of cultures of the producer bacterium, group A streptococcus strain FF22. SA-CA was solubilized by chemical, en... | [
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PMID:28693 | Mechanism of the antimicrobial action of pyrithione: effects on membrane transport, ATP levels, and protein synthesis. | Pyrithione is a general inhibitor of membrane transport processes in fungi. A brief preincubation of Penicillium mycelia with pyrithione resulted in a marked decrease in the activities of a variety of independently regulated transport systems, including those for inorganic sulfate, inorganic phosphate, methylamine (act... | Mechanism of the antimicrobial action of pyrithione: effects on membrane transport, ATP levels, and protein synthesis. Pyrithione is a general inhibitor of membrane transport processes in fungi. A brief preincubation of Penicillium mycelia with pyrithione resulted in a marked decrease in the activities of a variety of ... | [
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PMID:28694 | Piperacillin: in vitro evaluation. | The in vitro activity of a new semisynthetic penicillin, piperacillin, was determined against 577 clinical isolates of gram-positive cocci and gram-negative bacilli. A concentration of 12.5 mug/ml inhibited 92% of isolates of Pseudomonas aeruginosa, 82% of Serratia marcescens, 73% of Escherichia coli, 61% of Klebsiella... | Piperacillin: in vitro evaluation. The in vitro activity of a new semisynthetic penicillin, piperacillin, was determined against 577 clinical isolates of gram-positive cocci and gram-negative bacilli. A concentration of 12.5 mug/ml inhibited 92% of isolates of Pseudomonas aeruginosa, 82% of Serratia marcescens, 73% of ... | [
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PMID:28695 | Danger of bucolome in infants with hyperbilirubinaemia. Experimental evidence. | Effects of bucolome on congenitally jaundiced Gunn rats were examined. Plasma total bilirubin level fell immediately after a single injection of bucolome and the lowered level persisted for more than 6 hours. Plasma unbound-bilirubin level and cerebellar bilirubin content increased simultaneously with the drop in total... | Danger of bucolome in infants with hyperbilirubinaemia. Experimental evidence. Effects of bucolome on congenitally jaundiced Gunn rats were examined. Plasma total bilirubin level fell immediately after a single injection of bucolome and the lowered level persisted for more than 6 hours. Plasma unbound-bilirubin level a... | [
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PMID:28696 | [gamma-Glutamyl transpeptidase in human eccrine sweat (author's transl)]. | The concentration of gamma-glutamyl transpeptidase was determined in eccrine, thermal sweat of 56 healthy men (ages 20--60 years) and 48 healthy women (ages 17--55 years). Samples of sweat were collected from the chest and back. The concentrations of gamma-glutamyl transpeptidase showed great individual variations. The... | [gamma-Glutamyl transpeptidase in human eccrine sweat (author's transl)]. The concentration of gamma-glutamyl transpeptidase was determined in eccrine, thermal sweat of 56 healthy men (ages 20--60 years) and 48 healthy women (ages 17--55 years). Samples of sweat were collected from the chest and back. The concentration... | [
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PMID:28698 | Surgery for short esophagus with stricture: an experimental and clinical manometric study. | The surgical management of short esophagus with stricture has been simplified in recent years by the introduction of an esophageal lengthening procedure (Collis gastroplasty) combined with antireflux maneuvers, such as the Belsey and Nissen operations. This report compares the experimental and clinical manometric findi... | Surgery for short esophagus with stricture: an experimental and clinical manometric study. The surgical management of short esophagus with stricture has been simplified in recent years by the introduction of an esophageal lengthening procedure (Collis gastroplasty) combined with antireflux maneuvers, such as the Belsey... | [
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PMID:28699 | The neuropharmacological actions of amoxapine. | Amoxapine possesses a broad spectrum of psychotropic actions, including antidepressant and neuroleptic effects in animals. Antidepressant activity is characterized by its ability to inhibit tetrabenazine-induced depression, antagonize reserpine-induced hypothermia and enhance yohimbine lethality. Neuroleptic activity i... | The neuropharmacological actions of amoxapine. Amoxapine possesses a broad spectrum of psychotropic actions, including antidepressant and neuroleptic effects in animals. Antidepressant activity is characterized by its ability to inhibit tetrabenazine-induced depression, antagonize reserpine-induced hypothermia and enha... | [
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PMID:28700 | Deoxycytidine: a morphine antagonist. | Deoxycytidine antagonizes the analgesic action of morphine in the rat, morphine-induced respiratory depression in the rabbit and mitigates withdrawal in the dependent mouse. Administration of deoxycytidine does not precipitate the abstinence syndrome in dependent mice, a property shared by certain other endogenous morp... | Deoxycytidine: a morphine antagonist. Deoxycytidine antagonizes the analgesic action of morphine in the rat, morphine-induced respiratory depression in the rabbit and mitigates withdrawal in the dependent mouse. Administration of deoxycytidine does not precipitate the abstinence syndrome in dependent mice, a property s... | [
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PMID:28701 | The effect of chronic administration of digitoxin on the activity of the myocardial (Na + K)-ATPase in guinea-pigs. | When guinea-pigs were treated for 24 days with digitoxin 0.3 mg/kg s.c., the activity of the (Na + K)-ATPase of the heart muscle increased by about 30% compared to controls, whereas the enzymes prepared from kidney and brain showed no significant alteration in their activity. In animal species treated with digitoxin fo... | The effect of chronic administration of digitoxin on the activity of the myocardial (Na + K)-ATPase in guinea-pigs. When guinea-pigs were treated for 24 days with digitoxin 0.3 mg/kg s.c., the activity of the (Na + K)-ATPase of the heart muscle increased by about 30% compared to controls, whereas the enzymes prepared f... | [
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PMID:28697 | [Research of the soluble microbial substances in organic fluids for the rapid diagnosis of some infections and particularly of bacterial meningitis (author's transl)]. | A number of immunological and non-immunological techniques have been recently used to detect soluble microbial substances in body fluids of patients with acute meningitis, bacteremia, and lobar pneumonia. By the immunological methods capsular highly polymerized polisaccharide group- or type-specific antigens of the mos... | [Research of the soluble microbial substances in organic fluids for the rapid diagnosis of some infections and particularly of bacterial meningitis (author's transl)]. A number of immunological and non-immunological techniques have been recently used to detect soluble microbial substances in body fluids of patients wit... | [
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PMID:28702 | A study of the mechanism of transport of benzylpenicillin in the rat submaxillary gland. | In vitro studies performed on slices of rat submaxillary gland to evaluate uptake and efflux of 14C-benzylpenicillin (10(-6)M, 10(-5)M) showed that uptake of 14C-benzylpenicillin was not significantly altered by aeration with N2, addition of 10(-5)M CN- or 10(-3) M probenecid, or substitution of K2SO4 in place of NaCl ... | A study of the mechanism of transport of benzylpenicillin in the rat submaxillary gland. In vitro studies performed on slices of rat submaxillary gland to evaluate uptake and efflux of 14C-benzylpenicillin (10(-6)M, 10(-5)M) showed that uptake of 14C-benzylpenicillin was not significantly altered by aeration with N2, a... | [
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PMID:28703 | Adrenergic contribution to the motor transmission in the dog vas deferens. | Isolated vas deferens preparations from 9 dogs were subjected to electrical stimulation and chemical excitation under physiological conditions. The experimental smooth muscle cylinders were confined to the terminal 3 cm portions of either the distal 'urethral' segment or the proximal 'epididymal' segment. Intermittent ... | Adrenergic contribution to the motor transmission in the dog vas deferens. Isolated vas deferens preparations from 9 dogs were subjected to electrical stimulation and chemical excitation under physiological conditions. The experimental smooth muscle cylinders were confined to the terminal 3 cm portions of either the di... | [
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PMID:28704 | In vitro measurement of the beta-adrenergic blocking properties of ORF 12592, the 5-hydroxy analog of propranolol. | ORF 12592 caused concentration-dependent inhibition of isoproterenol stimulated adenylate cyclase activity in sarcolemma-enriched membrane preparations of guinea-pig myocardium. Its potency was slightly less than that of d,l-propranolol. ORF 12592 did not stimulate basal enzyme activity, suggesting it to be devoid of i... | In vitro measurement of the beta-adrenergic blocking properties of ORF 12592, the 5-hydroxy analog of propranolol. ORF 12592 caused concentration-dependent inhibition of isoproterenol stimulated adenylate cyclase activity in sarcolemma-enriched membrane preparations of guinea-pig myocardium. Its potency was slightly le... | [
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PMID:28705 | Bacteriologic flora of aspiration-induced pulmonary infections. | The role of anaerobic and aerobic microorganisms in the genesis of pneumonia or lung abscess in patients with historical, clinical, and radiologic findings suggestive of aspiration was compared to their role in similar patients without these findings. Bacterial specimens were obtained by transtracheal aspiration or tho... | Bacteriologic flora of aspiration-induced pulmonary infections. The role of anaerobic and aerobic microorganisms in the genesis of pneumonia or lung abscess in patients with historical, clinical, and radiologic findings suggestive of aspiration was compared to their role in similar patients without these findings. Bact... | [
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PMID:28706 | Physician extenders in walk-in clinics: a prospective evaluation of the AMOSIST program. | The Automated Military Outpatient System (AMOS) Project was developed to improve the ambulatory care of patients with episodic and chronic illnesses. During the development of its episodic care component, the relative frequency of problems treated by the walk-in clinic staff was analyzed and showed a high volume of acu... | Physician extenders in walk-in clinics: a prospective evaluation of the AMOSIST program. The Automated Military Outpatient System (AMOS) Project was developed to improve the ambulatory care of patients with episodic and chronic illnesses. During the development of its episodic care component, the relative frequency of ... | [
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PMID:28707 | The glucose-pH relationship in parapneumonic effusions. | Both a low pleural fluid glucose concentration and pleural fluid acidosis are markers of severe pleural inflammation, but the relationship between these phenomena has not been defined clearly. Therefore, we measured simultaneous pleural fluid glucose concentrations and pH in 25 consecutive parapneumonic pleural fluids.... | The glucose-pH relationship in parapneumonic effusions. Both a low pleural fluid glucose concentration and pleural fluid acidosis are markers of severe pleural inflammation, but the relationship between these phenomena has not been defined clearly. Therefore, we measured simultaneous pleural fluid glucose concentration... | [
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PMID:28708 | Hyperparathyroidism, chemodectoma, thymoma, and myasthenia gravis. | Of two patients with hyperparathyroidism, one had an associated chemodectoma, and the other had a thymoma and myasthenia gravis. There is a possible relationship to the multiple endocrine neoplasia syndromes. | Hyperparathyroidism, chemodectoma, thymoma, and myasthenia gravis. Of two patients with hyperparathyroidism, one had an associated chemodectoma, and the other had a thymoma and myasthenia gravis. There is a possible relationship to the multiple endocrine neoplasia syndromes. | [
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PMID:28709 | [The atrial arrhythmia syndrome of vagal origin]. | Having observed 18 cases, the authors describe a syndrome of recurrent paroxysmal atrial arrhythmia which was very homogeneous from the clinical and ECG point of view. It was usually found in middle aged males, with no demonstrable underlying heart disease, whose disorder of intra-atrial conduction occurred during sinu... | [The atrial arrhythmia syndrome of vagal origin]. Having observed 18 cases, the authors describe a syndrome of recurrent paroxysmal atrial arrhythmia which was very homogeneous from the clinical and ECG point of view. It was usually found in middle aged males, with no demonstrable underlying heart disease, whose disord... | [
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PMID:28710 | [Comparative study of acute poisonings in Belgian children and immigrant workers children]. | This survey covers 786 children admitted with acute poisoning to the Saint-Pierre Hospital in Brussels between 1967 and 1976. The type and the frequency of products responsible for poisoning in the indigenous and immigrant children are compared. 45% of children admitted to hospital are immigrants but they constitute on... | [Comparative study of acute poisonings in Belgian children and immigrant workers children]. This survey covers 786 children admitted with acute poisoning to the Saint-Pierre Hospital in Brussels between 1967 and 1976. The type and the frequency of products responsible for poisoning in the indigenous and immigrant child... | [
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PMID:28711 | "Akinetic depression" in schizophrenia. | It is possible that some "postpsychotic depressions" may be a toxic effect of antipsychotic drugs. Out of a total of 94 schizophrenic patients, 28 developed a mild akinesia and 32 never developed extrapyramidal symptoms. Those who developed akinesia became less psychotic, but they also experienced a significant, althou... | "Akinetic depression" in schizophrenia. It is possible that some "postpsychotic depressions" may be a toxic effect of antipsychotic drugs. Out of a total of 94 schizophrenic patients, 28 developed a mild akinesia and 32 never developed extrapyramidal symptoms. Those who developed akinesia became less psychotic, but the... | [
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PMID:28716 | [Barbexaclone in the treatment of cerebral dysrhythmia]. | Forty two patients (22 adults and 20 children or adolescents) with cerebral dysrithmia were included in a therapeutic trial using barbexaclone: 28 patients suffered from grand mal crises, 2 had associated GM and petit mal and 12 showed disturbances of behaviour without clinical crises. The patients were observed from 6... | [Barbexaclone in the treatment of cerebral dysrhythmia]. Forty two patients (22 adults and 20 children or adolescents) with cerebral dysrithmia were included in a therapeutic trial using barbexaclone: 28 patients suffered from grand mal crises, 2 had associated GM and petit mal and 12 showed disturbances of behaviour w... | [
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PMID:28713 | [The in-vivo effect of dihydroergocristine on human platelet function]. | An acute test was run on healthy volunteers to assess the effect of i.v. dihydroergocristine methansulphonate on platelet function. The number of platelets was virtually unaffected, whereas adhesion to glass was significantly reduced. A direct and specific effect was noted on the 1st, adrenaline aggregation wave, while... | [The in-vivo effect of dihydroergocristine on human platelet function]. An acute test was run on healthy volunteers to assess the effect of i.v. dihydroergocristine methansulphonate on platelet function. The number of platelets was virtually unaffected, whereas adhesion to glass was significantly reduced. A direct and ... | [
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PMID:28721 | Corrosive injury of the esophagus. Result of ingesting some denture cleanser tablets and powder. | Denture cleansers are ubiquitous compounds frequently found in the household. Experimental studies were carried out to investigate the caustic, chemical, and histopathological properties of Polident and Efferdent tablets and Ansodent powder. All products were found to have caused severe focal to diffuse caustic burns o... | Corrosive injury of the esophagus. Result of ingesting some denture cleanser tablets and powder. Denture cleansers are ubiquitous compounds frequently found in the household. Experimental studies were carried out to investigate the caustic, chemical, and histopathological properties of Polident and Efferdent tablets an... | [
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PMID:28723 | Effects of xylazine hydrochloride on urine in cattle. | Urine volume, urine pH, and urine glucose concentration were monitored for up to 24 hours after physiological saline or one of two dosage levels (0.22 mg/kg or 0.44 mg/kg) of xylazine was administered to cows. During the first 2 hours after xylazine was given, urine output was greatly increased (relative to the control... | Effects of xylazine hydrochloride on urine in cattle. Urine volume, urine pH, and urine glucose concentration were monitored for up to 24 hours after physiological saline or one of two dosage levels (0.22 mg/kg or 0.44 mg/kg) of xylazine was administered to cows. During the first 2 hours after xylazine was given, urine... | [
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PMID:28725 | A characterization of the nucleotide uptake of chromaffin granules of bovine adrenal medulla. | Chromaffin granules isolated from bovine adrenal gland were incubated with (3)H-labelled nucleotides and [(14)C]noradrenaline to study the uptake of these substances. [(3)H]ATP, [(3)H]ADP and [(3)H]AMP are taken up by these organelles by the same temperature-dependent mechanism. The apparent K(m) for ATP and ADP is 1.4... | A characterization of the nucleotide uptake of chromaffin granules of bovine adrenal medulla. Chromaffin granules isolated from bovine adrenal gland were incubated with (3)H-labelled nucleotides and [(14)C]noradrenaline to study the uptake of these substances. [(3)H]ATP, [(3)H]ADP and [(3)H]AMP are taken up by these or... | [
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PMID:28726 | Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier. | The effects of exchangeable ions and pH on the efflux of pyruvate from preloaded mitochondria are reported. Efflux obeys first-order kinetics, and the stimulation of efflux by exchangeable ions such as acetoacetate and lactate obeys Michaelis--Menten kinetics. The apparent Km value +/- S.E. for acetoacetate was 0.56 +/... | Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier. The effects of exchangeable ions and pH on the efflux of pyruvate from preloaded mitochondria are reported. Efflux obeys first-order kinetics, and the stimulation of efflux by exchangea... | [
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PMID:28727 | Stimulation of pyruvate transport in metabolizing mitochondria through changes in the transmembrane pH gradient induced by glucagon treatment of rats. | Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media. No change in the activity of the pyruvate carrier itself was apparent, but under metabolizing conditions, use of the inhibitor of pyruvate transport, alpha-cyano-4-h... | Stimulation of pyruvate transport in metabolizing mitochondria through changes in the transmembrane pH gradient induced by glucagon treatment of rats. Glucagon treatment of rats allowed the isolation of liver mitochondria with enhanced rates of pyruvate metabolism measured in either sucrose or KCl media. No change in t... | [
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PMID:28728 | Kinetics of liver microsomal cholecalciferol 25-hydroxylase in vitamin D-depleted and -repleated rats. | Kinetics of vitamin D-depleted and -repleted rat liver microsomal cholecalciferol 25-hydroxylase were studied. Anaerobiosis, CO, omission of a NADPH-generating system and addition of detergents all decreased the activities, showing that the hydroxylase behaves like a cytochrome P-450-dependent enzyme. An apparent Km of... | Kinetics of liver microsomal cholecalciferol 25-hydroxylase in vitamin D-depleted and -repleated rats. Kinetics of vitamin D-depleted and -repleted rat liver microsomal cholecalciferol 25-hydroxylase were studied. Anaerobiosis, CO, omission of a NADPH-generating system and addition of detergents all decreased the activ... | [
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PMID:28729 | The uptake of silicic acid by rat liver mitochondria. | 1. To gain insight into a putative role for mitochondria in silicon metabolism, mitochondrial uptake (by which it is meant the removal from the medium) of silicic acid [Si(OH)4] was studied under conditions minimizing SI(OH)4 polymerization. 2. Measurements of mitochondrial respiration and swelling indicated indirectly... | The uptake of silicic acid by rat liver mitochondria. 1. To gain insight into a putative role for mitochondria in silicon metabolism, mitochondrial uptake (by which it is meant the removal from the medium) of silicic acid [Si(OH)4] was studied under conditions minimizing SI(OH)4 polymerization. 2. Measurements of mitoc... | [
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PMID:28730 | The nature of the allosteric interactions of ribonuclease and its ligands. | The allosteric model for ribonuclease activity by Walker, Ralston & Darvey [(1975) Biochem.J. 147, 425--433; (1976) Biochem.J. 153, 329--337] involves the binding of a large number of molecules of substrate or substrate analogue to a series of allosteric sites on the enzyme. In the present paper, the nature of thes... | The nature of the allosteric interactions of ribonuclease and its ligands. The allosteric model for ribonuclease activity by Walker, Ralston & Darvey [(1975) Biochem.J. 147, 425--433; (1976) Biochem.J. 153, 329--337] involves the binding of a large number of molecules of substrate or substrate analogue to a series ... | [
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PMID:28731 | Periodate oxidation and the shapes of glycosaminoglycuronans in solution. | 1. It is proposed that periodate oxidation of glycol groups in the repeating units of polysaccharide molecules can be used to probe differences in polymer shapes in solution. 2. Measurement of second-order rate constants (k2) of periodate-glycol reactions may be compared between polymers and relevant monomers, to asses... | Periodate oxidation and the shapes of glycosaminoglycuronans in solution. 1. It is proposed that periodate oxidation of glycol groups in the repeating units of polysaccharide molecules can be used to probe differences in polymer shapes in solution. 2. Measurement of second-order rate constants (k2) of periodate-glycol ... | [
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PMID:28732 | The enzymes of proline biosynthesis in Escherichia coli. Their molecular weights and the problem of enzyme aggregation. | 1. By using Bio-Gel A1.5M and Sephadex G-150 columns, crude cell-free extracts of Escherichia coli were fractionated to demonstrate the existence of a proline-biosynthetic aggregate. 2. Sephadex G-150 resolves two glutamyl kinases that are inhibited by proline, with mol.wts. of 125000 and 38000, the reactions of which ... | The enzymes of proline biosynthesis in Escherichia coli. Their molecular weights and the problem of enzyme aggregation. 1. By using Bio-Gel A1.5M and Sephadex G-150 columns, crude cell-free extracts of Escherichia coli were fractionated to demonstrate the existence of a proline-biosynthetic aggregate. 2. Sephadex G-150... | [
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PMID:28733 | pH-dependent changes of intrinsic fluorescence of chemically modified liver alcohol dehydrogenases. | Horse liver alcohol dehydrogenase specifically carboxymethylated on cysteine-46 (a ligand to the zinc in the active site) or acetimidylated on 25 of the 30 lysine residues per subunit (including residue 228) was studied. The tryptophan fluorescence of these enzymes decreased by 35% as pH was increased, with an apparent... | pH-dependent changes of intrinsic fluorescence of chemically modified liver alcohol dehydrogenases. Horse liver alcohol dehydrogenase specifically carboxymethylated on cysteine-46 (a ligand to the zinc in the active site) or acetimidylated on 25 of the 30 lysine residues per subunit (including residue 228) was studied.... | [
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PMID:28734 | The inactivation of native enzymes by a neutral proteinase from rat intestinal muscle. | 1. The solubilization and partial purification of a proteinase from the intestinal smooth muscle of rats fed on protein-free diets are described. 2. It has a mol.wt. of about 33000 and it is stable over a narrow pH range. 3. From its susceptibility to known modifers of proteolytic enzymes, it appears to be a serine pro... | The inactivation of native enzymes by a neutral proteinase from rat intestinal muscle. 1. The solubilization and partial purification of a proteinase from the intestinal smooth muscle of rats fed on protein-free diets are described. 2. It has a mol.wt. of about 33000 and it is stable over a narrow pH range. 3. From its... | [
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PMID:28735 | Kinetics and mechanism of the rat brain phenol sulphotransferase reaction. | Some properties of rat brain phenol sulphotransferase were investigated in in vitro at pH7.4. The enzyme was purified 10-fold by chromatography on DEAE-Sephadex -50. It can be assayed with 4-hydroxy-3-methoxyphenylethylene glycol or 4-methylumbelliferone as the sulphate acceptor. The partially purified enzyme is stable... | Kinetics and mechanism of the rat brain phenol sulphotransferase reaction. Some properties of rat brain phenol sulphotransferase were investigated in in vitro at pH7.4. The enzyme was purified 10-fold by chromatography on DEAE-Sephadex -50. It can be assayed with 4-hydroxy-3-methoxyphenylethylene glycol or 4-methylumbe... | [
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PMID:28736 | Inactivation of glutamate dehydrogenase and glutamate synthase from Bacillus megaterium by phenylglyoxal, butane-2,3-dione and pyridoxal 5'-phosphate. | Reaction of phenylglyoxal with glutamate dehydrogenase (EC 1.4.1.4), but not with glutamate synthase (EC 2.6.1.53), from Bacillus megaterium resulted in complete loss of enzyme activity. NADPH alone or together with 2-oxoglutarate provided substantial protection from inactivation by phenylglyoxal. Some 2mol of [14C]Phe... | Inactivation of glutamate dehydrogenase and glutamate synthase from Bacillus megaterium by phenylglyoxal, butane-2,3-dione and pyridoxal 5'-phosphate. Reaction of phenylglyoxal with glutamate dehydrogenase (EC 1.4.1.4), but not with glutamate synthase (EC 2.6.1.53), from Bacillus megaterium resulted in complete loss of... | [
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PMID:28737 | Properties of matrix-bound dimer and monomer derivatives of immobilized creatine kinase from rabbit skeletal muscle. | Dimeric creatine kinase (EC 2.7.3.2) from rabbit skeletal muscle can be immobilized via a single subunit to CNBr-activated Sepharose 4B and subsequently treated with guanidine hydrochloride followed by renaturation to yield a catalytically active matrix-bound subunit derivative. The importance of the intact dimeric str... | Properties of matrix-bound dimer and monomer derivatives of immobilized creatine kinase from rabbit skeletal muscle. Dimeric creatine kinase (EC 2.7.3.2) from rabbit skeletal muscle can be immobilized via a single subunit to CNBr-activated Sepharose 4B and subsequently treated with guanidine hydrochloride followed by r... | [
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PMID:28738 | Purification and immunochemical characterization of malate synthase from Euglena gracilis. | Malate synthase (EC 4.1.3.2) from dark-grown Euglena gracilis was purified to homogeneity by the criterion of polyacrylamide-gel electrophoresis. The enzyme was released from acetate-grown cells by treatment with ultrasonic waves and purified from broken-cell suspensions by high-speed centrifugation and (NH4)2SO4 fract... | Purification and immunochemical characterization of malate synthase from Euglena gracilis. Malate synthase (EC 4.1.3.2) from dark-grown Euglena gracilis was purified to homogeneity by the criterion of polyacrylamide-gel electrophoresis. The enzyme was released from acetate-grown cells by treatment with ultrasonic waves... | [
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PMID:28739 | Effects of prolonged administration of high molecular levan on arterial blood gases, oxygen transport and acid base balance in rabbits. | The effect of daily intraperitoneal injections of 100 mg of high molecular levan for 4-6 weeks on a number of physiological parameters was studied in rabbits. The parameters studied included whole blood pH, blood gases and acid-base balance. Control rabbits were similarly treated with physiological saline. In five rabb... | Effects of prolonged administration of high molecular levan on arterial blood gases, oxygen transport and acid base balance in rabbits. The effect of daily intraperitoneal injections of 100 mg of high molecular levan for 4-6 weeks on a number of physiological parameters was studied in rabbits. The parameters studied in... | [
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PMID:28740 | [Correlation of vasospasm and intracranial metabolism under experimental subarachnoid hemorrhage--Part 1. In reference with the acid-base-balance of cerebral blood and cerebrospinal fluid]. | Cerebral vasospasm, cerebral metabolism and the acid-base-balance of blood and cerebrospinal fluid of dogs were studied during and after the experimental subarachnoid hemorrhage. Subarachnoid hemorrhage was induced by infusion of fresh blood into the basal cistern through a small sraniectomy in the base of the skull. ... | [Correlation of vasospasm and intracranial metabolism under experimental subarachnoid hemorrhage--Part 1. In reference with the acid-base-balance of cerebral blood and cerebrospinal fluid]. Cerebral vasospasm, cerebral metabolism and the acid-base-balance of blood and cerebrospinal fluid of dogs were studied during an... | [
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PMID:28745 | Characterization of the reaction of methyl acetimidate with sperm whale myoglobin. | The effects of pH, acetimidate concentration, temperature, and reaction time of methyl acetimidate with sperm whale myoglobulin have been assessed. Reaction at pH 9.8 and 15 degrees C for 30 min with a sixfold excess of methyl acetimidate relative to each amino group yielded six acetimidomyoglobin derivatives which wer... | Characterization of the reaction of methyl acetimidate with sperm whale myoglobin. The effects of pH, acetimidate concentration, temperature, and reaction time of methyl acetimidate with sperm whale myoglobulin have been assessed. Reaction at pH 9.8 and 15 degrees C for 30 min with a sixfold excess of methyl acetimidat... | [
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PMID:28746 | Properties of D-amino acid oxidase covalently modified upon its oxidation of D-propargylglycine. | Upon oxidation of D-propargylglycine by D-amino acid oxidase, the enzyme is converted by covalent alkylation to catalytic species with different properties from those of native enzyme. At least five distinct modified enzyme species are present in the preparation, as determined by gel electro-focusing. Individual charac... | Properties of D-amino acid oxidase covalently modified upon its oxidation of D-propargylglycine. Upon oxidation of D-propargylglycine by D-amino acid oxidase, the enzyme is converted by covalent alkylation to catalytic species with different properties from those of native enzyme. At least five distinct modified enzyme... | [
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PMID:28748 | Quantitation of hydrogen ion and potential gradients in gastric plasma membrane vesicles. | The ATP-dependent uptake of H+ by hog gastric parietal cell vesicles was quantitated by using the pH indicator dyes bromcresol green and malachite green, the weak bases, aminopyrine and 9-aminoacridine, and the pH electrode. A K+-dependent H+ uptake was found, with a significant difference between the quantity of H+ di... | Quantitation of hydrogen ion and potential gradients in gastric plasma membrane vesicles. The ATP-dependent uptake of H+ by hog gastric parietal cell vesicles was quantitated by using the pH indicator dyes bromcresol green and malachite green, the weak bases, aminopyrine and 9-aminoacridine, and the pH electrode. A K+-... | [
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PMID:28750 | Threonine inhibition of the aspartokinase--homoserine dehydrogenase I of Escherichia coli. Threonine binding studies. | Both activities of the aspartokinase--homoserine I (AK-HSD) of Escherichia coli are inhibited by threonine. Careful threonine binding studies have now been done which have allowed us to distinguish the various effects of threonine on the enzyme. The ultrafiltration technique of H. Paulus ((1969) Anal. Biochem. 32, 101)... | Threonine inhibition of the aspartokinase--homoserine dehydrogenase I of Escherichia coli. Threonine binding studies. Both activities of the aspartokinase--homoserine I (AK-HSD) of Escherichia coli are inhibited by threonine. Careful threonine binding studies have now been done which have allowed us to distinguish the ... | [
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PMID:28755 | Sidedness of inhibition of energy transduction in oxidative phosphorylation in rat liver mitochondria by ethidium bromide. | Ethidium bromide, a new type of inhibitor of energy transduction in oxidative phosphorylation, inhibited ATP synthesis in intact mitochondria but not in submitochondrial particles, the latter being inside-out relative to the membranes of intact mitochondria. Ethidium bromide incorporated inside the submitochondrial par... | Sidedness of inhibition of energy transduction in oxidative phosphorylation in rat liver mitochondria by ethidium bromide. Ethidium bromide, a new type of inhibitor of energy transduction in oxidative phosphorylation, inhibited ATP synthesis in intact mitochondria but not in submitochondrial particles, the latter being... | [
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PMID:28756 | Mechanism of generation and regulation of photopotential by bacteriorhodopsin in bimolecular lipid membrane. | Photoelectric properties of bacteriorhodopsin incorporated into a bimolecular lipid membrane were investigated with special regard to the mechanism of photoelectric field generation. It was shown that besides its proton pump and electric generator functions bacteriorhodopsin works as a possible molecular regulator of t... | Mechanism of generation and regulation of photopotential by bacteriorhodopsin in bimolecular lipid membrane. Photoelectric properties of bacteriorhodopsin incorporated into a bimolecular lipid membrane were investigated with special regard to the mechanism of photoelectric field generation. It was shown that besides it... | [
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PMID:28757 | Two distinct rhodopsin molecules within the disc membrane of vertebrate rod outer segments. | The kinetics of the metarhodopsin I-II reaction have been measured over a wide range of temperatures (1-37C ) and pH values (4.5-8) with suspensions containing fragments of bovine rod outer segments. It was found that for all conditions the occurrence of metarhodopsin II could be described by two independent first-orde... | Two distinct rhodopsin molecules within the disc membrane of vertebrate rod outer segments. The kinetics of the metarhodopsin I-II reaction have been measured over a wide range of temperatures (1-37C ) and pH values (4.5-8) with suspensions containing fragments of bovine rod outer segments. It was found that for all co... | [
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PMID:28758 | Inside-out membrane vesicles isolated from spinach thylakoids. | Inside-out thylakoid vesicles have been separated from right-side-out material after press disruption of chloroplast lamellae. The sepration was obtained by partitionin an aqueous dextran-polyethylene glycol two-phase system, a method which utilizes differences in surface properties for separation of membrane particles... | Inside-out membrane vesicles isolated from spinach thylakoids. Inside-out thylakoid vesicles have been separated from right-side-out material after press disruption of chloroplast lamellae. The sepration was obtained by partitionin an aqueous dextran-polyethylene glycol two-phase system, a method which utilizes differe... | [
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PMID:28759 | Effect of chemical modification of amino groups by fluorescamine on partial reactions of photosynthesis. | 4-Phenylspiro [furan-2(3H),1-phtalan]3,3'-dione (fluorescamine) was used to covalently modify amino groups of thylakoids. Subsequently its effect on parameters of energy transfer and phosphorylating activity was assessed. While electron transport, the extent of proton uptake, 515 nm change and 9-aminoacridine quench we... | Effect of chemical modification of amino groups by fluorescamine on partial reactions of photosynthesis. 4-Phenylspiro [furan-2(3H),1-phtalan]3,3'-dione (fluorescamine) was used to covalently modify amino groups of thylakoids. Subsequently its effect on parameters of energy transfer and phosphorylating activity was ass... | [
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PMID:28760 | Redox potentials of the photosynthetic bacterial cytochromes c2 and the structural bases for variability. | The cytochromes c2 of the Rhodospirillaceae show a much greater variation in redox potential and its pH dependence than the mitochondrial cytochromes c that have been studied. It is proposed that the range of redox potential for cytochromes c2 functioning as the immediate electron donor to photo-oxidised bacteriochloro... | Redox potentials of the photosynthetic bacterial cytochromes c2 and the structural bases for variability. The cytochromes c2 of the Rhodospirillaceae show a much greater variation in redox potential and its pH dependence than the mitochondrial cytochromes c that have been studied. It is proposed that the range of redox... | [
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PMID:28761 | The influence of pH on the conductance of lipid bimolecular membranes in relation to the alkaline ion transport induced by carboxylic carriers grisorixin, alborixin and monensin. | The influence of the pH on the stability and stoichiometry of the complexes formed by carboxylic-antibiotics such as grisorixin, alborixin and monensin with alkaline and alkaline earth cations has been investigated. The maximum values of bimolecular lipid membrane conductance are obtained with grisorixin and potassium ... | The influence of pH on the conductance of lipid bimolecular membranes in relation to the alkaline ion transport induced by carboxylic carriers grisorixin, alborixin and monensin. The influence of the pH on the stability and stoichiometry of the complexes formed by carboxylic-antibiotics such as grisorixin, alborixin an... | [
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PMID:28763 | Purification and properties of an induced beta-D-glucosidase from stachybotrys atra. | We have purified an induced beta-D-glucosidase (beta-D-glucoside glucohydrolase, EC 3.2.1.21) from Stachybotrys atra to apparent homogeneity. The induced enzyme was clearly different from the constitutive beta-D-glucosidase. The molecular weight was 65 500-69 000, the pH optimum was at 6.7 and the isoelectric point at ... | Purification and properties of an induced beta-D-glucosidase from stachybotrys atra. We have purified an induced beta-D-glucosidase (beta-D-glucoside glucohydrolase, EC 3.2.1.21) from Stachybotrys atra to apparent homogeneity. The induced enzyme was clearly different from the constitutive beta-D-glucosidase. The molecu... | [
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PMID:28765 | The two human trypsinogens: catalytic properties of the corresponding trypsins. | The catalytic properties of the two human trypsins obtained from purified trypsinogens have been studied. The catalytic rate constant kcat and the pK of the ionisable residue implicated in the active site have been determined with Bz-Arg-OEt. The hydrolysis of Tos-Arg-OMe by human trypsins does not follow the simple Mi... | The two human trypsinogens: catalytic properties of the corresponding trypsins. The catalytic properties of the two human trypsins obtained from purified trypsinogens have been studied. The catalytic rate constant kcat and the pK of the ionisable residue implicated in the active site have been determined with Bz-Arg-OE... | [
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PMID:28766 | Purification and characterization of a myosin-cleaving protease from rat heart myofibrils. | A proteolytic enzyme, which causes the limited degradation of cardiac myosin, was purified from rat heart myofibrils. The purified enzyme (a myosin-cleaving protease) was apparently homogeneous by polyacrylamide gel electrophoresis in the presence and absence of sodium dodecyl sulfate. Autolysis of the purified enzyme ... | Purification and characterization of a myosin-cleaving protease from rat heart myofibrils. A proteolytic enzyme, which causes the limited degradation of cardiac myosin, was purified from rat heart myofibrils. The purified enzyme (a myosin-cleaving protease) was apparently homogeneous by polyacrylamide gel electrophores... | [
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PMID:28767 | Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain. | Guanylate cyclase (GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2) was purified 2250-fold from the synaptosomal soluble fraction of rat brain. The specific activity of the purified enzyme reached 41 nmol cyclic GMP formed per min per mg protein at 37 degrees C. In the purified preparation, GTPase activity was not dete... | Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain. Guanylate cyclase (GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2) was purified 2250-fold from the synaptosomal soluble fraction of rat brain. The specific activity of the purified enzyme reached 41 nmol cyclic GMP fo... | [
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PMID:28768 | Immobilized hybrids of glyceraldehyde-3-phosphate dehydrogenase. | Yeast glyceraldehyde-3-phosphate dehydrogenase (glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12) immobilized on CNBr-activated Sepharose 4-B has been subjected to dissociation to obtain matrix-bound dimeric species of the enzyme. Hybridization was then performed using soluble glyceraldehyd... | Immobilized hybrids of glyceraldehyde-3-phosphate dehydrogenase. Yeast glyceraldehyde-3-phosphate dehydrogenase (glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12) immobilized on CNBr-activated Sepharose 4-B has been subjected to dissociation to obtain matrix-bound dimeric species of the enz... | [
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PMID:28770 | The kinetics of methyl viologen oxidation and reduction by the hydrogenase from Clostridium pasteurianum. | A mechanism for the reduction and oxidation of methyl viologen by Clostridium pasteurianum hydrogenase (hydrogen:ferredoxin oxidoreductase, EC 1.12.7.1) is proposed. Double reciprocal plots for methyl viologen reduction and oxidation at pH values 7.0-9.85 are linear, and the plots for reduction and oxidation are inters... | The kinetics of methyl viologen oxidation and reduction by the hydrogenase from Clostridium pasteurianum. A mechanism for the reduction and oxidation of methyl viologen by Clostridium pasteurianum hydrogenase (hydrogen:ferredoxin oxidoreductase, EC 1.12.7.1) is proposed. Double reciprocal plots for methyl viologen redu... | [
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PMID:28771 | Esterase XXVII. Purification and characterization of esterase-9A of mouse kidney. | Esterase-9A, which appears electrophoretically as a triplet of the bands III-50, III-40 and III-30, was isolated from the kidneys of male NMRI-mice by isoelectrofocusing and refocusing followed by repeated molecular sieve chromography. The overall purification was approx. 250 fold and each of the three bands was isolat... | Esterase XXVII. Purification and characterization of esterase-9A of mouse kidney. Esterase-9A, which appears electrophoretically as a triplet of the bands III-50, III-40 and III-30, was isolated from the kidneys of male NMRI-mice by isoelectrofocusing and refocusing followed by repeated molecular sieve chromography. Th... | [
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PMID:28772 | Characterization of sterol-ester hydrolase in Saccharomyces cerevisiae. | A homgenate of Saccharomyces cerevisiae grown under semi-anaerobic as well as aerobic conditions was found to catalyze the hydrolysis of fatty acid esters of sterols in the presence of Triton X-100. The enzyme levels in cells grown under various conditions were similar and the enzyme had a broad substrate specificity f... | Characterization of sterol-ester hydrolase in Saccharomyces cerevisiae. A homgenate of Saccharomyces cerevisiae grown under semi-anaerobic as well as aerobic conditions was found to catalyze the hydrolysis of fatty acid esters of sterols in the presence of Triton X-100. The enzyme levels in cells grown under various co... | [
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PMID:28773 | Temperature and pH effects with immobilized electric eel acetylcholinesterase. | Kinetic studies were made with 2 forms of immobilized acetylcholinesterase: enzyme trapped in polyacrylamide gel which was cut into slices; and enzyme attached to the inner surface of nylon tubing. Rates were measured at substrate concentrations which were low and high with reference to the Michaelis constant, and over... | Temperature and pH effects with immobilized electric eel acetylcholinesterase. Kinetic studies were made with 2 forms of immobilized acetylcholinesterase: enzyme trapped in polyacrylamide gel which was cut into slices; and enzyme attached to the inner surface of nylon tubing. Rates were measured at substrate concentrat... | [
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PMID:28774 | Enzyme behaviour and molecular environment. The effects of ionic strength, detergents, linear polyanions and phospholipids on the pH profile of soluble cytochrome oxidase. | The activity vs. pH profile for the oxidation of ferrocytochrome c by purified cytochrome oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) was investigated as a function of ionic strength (from 10 to 200 mM) in the absence and in the presence of various perturbants: Tween 20, linear polyanions (RNA, hepari... | Enzyme behaviour and molecular environment. The effects of ionic strength, detergents, linear polyanions and phospholipids on the pH profile of soluble cytochrome oxidase. The activity vs. pH profile for the oxidation of ferrocytochrome c by purified cytochrome oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3... | [
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PMID:28775 | Zinc stoichiometry in Escherichia coli alkaline phosphatase. Studies by 31P NMR and ion-exchange chromatography. | 31P nuclear magnetic resonance spectra and enzymatic activities are compared for alkaline phosphatase (orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1) species with different zinc contents. The enzyme containing two Zn2+ per protein dimer exists in two forms; one, prepared by dialysis of nativ... | Zinc stoichiometry in Escherichia coli alkaline phosphatase. Studies by 31P NMR and ion-exchange chromatography. 31P nuclear magnetic resonance spectra and enzymatic activities are compared for alkaline phosphatase (orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1) species with different zinc c... | [
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PMID:28776 | NMR and enzymatic investigation of the interaction between elastase and sodium trifluoroacetate. | At pH 5.5, sodium trifluoroacetate is a potent competitive inhibitor of porcine elastase (Ki = 2.6 mM) and human leukocyte elastase (Ki = 9.3 mM). For both enzymes the Ki increases strongly with pH. Sodium fluoride is inactive on pancreatic elastase and sodium acetate is a weak inhibitor of this enzyme. Trifluoroethano... | NMR and enzymatic investigation of the interaction between elastase and sodium trifluoroacetate. At pH 5.5, sodium trifluoroacetate is a potent competitive inhibitor of porcine elastase (Ki = 2.6 mM) and human leukocyte elastase (Ki = 9.3 mM). For both enzymes the Ki increases strongly with pH. Sodium fluoride is inact... | [
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PMID:28777 | Purification and properties of pig brain guanine deaminase. | Guanine deaminase (guanine aminohydrolase, EC 3.5.4.3) from pig brain was purified to homogeneity by column chromatography and ammonium sulphate fractionation. Homogeneity was established by polyacrylamide gel electrophoresis in the presence and absence of sodium dodecyl sulphate (SDS). The molecular weight of 110 000 ... | Purification and properties of pig brain guanine deaminase. Guanine deaminase (guanine aminohydrolase, EC 3.5.4.3) from pig brain was purified to homogeneity by column chromatography and ammonium sulphate fractionation. Homogeneity was established by polyacrylamide gel electrophoresis in the presence and absence of sod... | [
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PMID:28778 | [Purification and detection of multiple forms of histidine decarboxylase in rat gastric mucosa (author's transl)]. | A specific histidine decarboxylase from rat gastric mucosa has been obtained at high purity and good yield (purification about 600-fold). The purification procedure included double (NH4)2SO4 fractionation, ion-exchange chromatography, preparative isoelectric focusing in a granulated gel and gel filtration. Only the spe... | [Purification and detection of multiple forms of histidine decarboxylase in rat gastric mucosa (author's transl)]. A specific histidine decarboxylase from rat gastric mucosa has been obtained at high purity and good yield (purification about 600-fold). The purification procedure included double (NH4)2SO4 fractionation,... | [
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PMID:28779 | Hydrogen bonding of flavoprotein. I. Effect of hydrogen bonding on electronic spectra of flavoprotein. | The effect of hydrogen bonding on the transition energy and the oscillator strength of the isoalloxazine nucleus of flavins was studied by the molecular orbital method. Among the possible hydrogen bondings examined, characteristic spectral shifts were found for the hydrogen bondings at N(1) and N(5) of the nucleus. The... | Hydrogen bonding of flavoprotein. I. Effect of hydrogen bonding on electronic spectra of flavoprotein. The effect of hydrogen bonding on the transition energy and the oscillator strength of the isoalloxazine nucleus of flavins was studied by the molecular orbital method. Among the possible hydrogen bondings examined, c... | [
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PMID:28780 | Soluble NADH-cytochrome b5 reductase from rabbit liver cytosol: partial purification and characterization. | A soluble form of NADH-cytochrome b5 reductase (NADH: ferricytochrome b5 oxidoreductase, EC 1.6.2.2) was found in the cytosolic fraction of rabbit liver. The partially purified enzyme was strictly specific for NADH. It catalyzed the reduction of several substrates such as the methemoglobin-ferrocyanide complex (Hegesh,... | Soluble NADH-cytochrome b5 reductase from rabbit liver cytosol: partial purification and characterization. A soluble form of NADH-cytochrome b5 reductase (NADH: ferricytochrome b5 oxidoreductase, EC 1.6.2.2) was found in the cytosolic fraction of rabbit liver. The partially purified enzyme was strictly specific for NAD... | [
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PMID:28781 | Purification and properties of rat liver mitochondrial glutathione peroxidase. | Glutathione peroxidase (glutathione:hydrogen peroxide oxidoreductase, EC 1.11.1.9) was purified from rat liver mitochondria. The enzyme was shown to be pure by polyacrylamide-gel electrophoresis and to contain multiple forms that differed in charge. Selenium was specifically associated with the enzyme. The enzyme was i... | Purification and properties of rat liver mitochondrial glutathione peroxidase. Glutathione peroxidase (glutathione:hydrogen peroxide oxidoreductase, EC 1.11.1.9) was purified from rat liver mitochondria. The enzyme was shown to be pure by polyacrylamide-gel electrophoresis and to contain multiple forms that differed in... | [
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PMID:28782 | N-Acetyltransferase activity of the rat Harderian gland. | Harderian gland extracts from male rats catalyze the conversion of serotonin to N-acetylserotonin and of tryptamine to N-acetyltryptamine. The reaction is linear up to 14 mg tissue and departs from linearity after 10 min. The pH otpimum with tryptamine as substrate is between 8 and 9. Enzymic activity of the gland in v... | N-Acetyltransferase activity of the rat Harderian gland. Harderian gland extracts from male rats catalyze the conversion of serotonin to N-acetylserotonin and of tryptamine to N-acetyltryptamine. The reaction is linear up to 14 mg tissue and departs from linearity after 10 min. The pH otpimum with tryptamine as substra... | [
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PMID:28783 | Cholesteryl ester and triglyceride hydrolysis by an acid lipase from rabbit aorta. | The properties of the triglyceride- and cholesteryl ester-hydrolyzing activity by an acid lipase from rabbit aortic tissue were compared under different experimental conditions. Radiolabeled cholesteryl oleate or triolein was incorporated into phospholipid vesicles by sonication and the resulting preparations were used... | Cholesteryl ester and triglyceride hydrolysis by an acid lipase from rabbit aorta. The properties of the triglyceride- and cholesteryl ester-hydrolyzing activity by an acid lipase from rabbit aortic tissue were compared under different experimental conditions. Radiolabeled cholesteryl oleate or triolein was incorporate... | [
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PMID:28784 | A protease-like permeability factor in the guinea pig skin. 2. In vitro activation of the latent form permeability factor by weakly acidic phosphate buffer. | Conditions for the in vitro activation of the latent form of a protease-like permeability factor in the pseudoglobulin fraction from guinea pig skin were examined. (1) The factor was activated by dialysis against 67 mM phosphate buffer at pH 5.8--6.4, not at pH 7.0--8.0. (2) High salt concentration (200 mM or greater p... | A protease-like permeability factor in the guinea pig skin. 2. In vitro activation of the latent form permeability factor by weakly acidic phosphate buffer. Conditions for the in vitro activation of the latent form of a protease-like permeability factor in the pseudoglobulin fraction from guinea pig skin were examined.... | [
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PMID:28785 | Aggregation of ampholine on heparin and other acidic polysaccharides in isoelectric focusing. | The mechanism of complexation of pI range 3.5--5 Ampholine to heparin in isoelectric focusing has been explored by the dye-binding technique at different pH values in solution. There is no significant interaction between heparin and Ampholine at pH 6.7. Weak, or selective, binding occurs at pH 5.1, and very strong inte... | Aggregation of ampholine on heparin and other acidic polysaccharides in isoelectric focusing. The mechanism of complexation of pI range 3.5--5 Ampholine to heparin in isoelectric focusing has been explored by the dye-binding technique at different pH values in solution. There is no significant interaction between hepar... | [
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PMID:28786 | Selective polyamine-binding proteins. Spermine binding by an androgen-sensitive phosphoprotein. | Rat ventral prostate contains an acidic protein which can bind spermine selectively. The relative binding affinities of various aliphatic amines for the protein are, in decreasing order, spermine greater than thermine greater than greater than putrecine greater than 1,10-diaminodecane, cadaverine and 1,12-diaminododeca... | Selective polyamine-binding proteins. Spermine binding by an androgen-sensitive phosphoprotein. Rat ventral prostate contains an acidic protein which can bind spermine selectively. The relative binding affinities of various aliphatic amines for the protein are, in decreasing order, spermine greater than thermine greate... | [
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PMID:28787 | Apparent stability constants of H+ and Mg2" complexes of 5-phosphoribosyl alpha-1-pyrophosphate. | Apparent Mg2+ and H+ stability constants of 5-phosphoribosyl alpha-1-pyrophosphate (ligand, L) complexes were determined from pH titration data at 25 degrees C with an average of 0.17 M NaCl or KCl and 0.20 M ionic strength. The logarithms of calculated macroscopic overall stability constants are: 3.2 (MgL3-), 4.8 (Mg2... | Apparent stability constants of H+ and Mg2" complexes of 5-phosphoribosyl alpha-1-pyrophosphate. Apparent Mg2+ and H+ stability constants of 5-phosphoribosyl alpha-1-pyrophosphate (ligand, L) complexes were determined from pH titration data at 25 degrees C with an average of 0.17 M NaCl or KCl and 0.20 M ionic strength... | [
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PMID:28788 | 3-Chloroacetylpyridine adenine dinucleotide phosphate, an alkylating analogue of NADP+. | An alkylating analogue of NADP+ the 3-chloroacetylpyridine adenine dinucleotide phosphate was prepared from 3-diazoacetylpyridine adenine dinucleotide phosphate which was obtained by enzymatic transglucosidation of NADP+. The 3-diazoacetylpyridine adenine dinucleotide phosphate proved to be more unstable when compared ... | 3-Chloroacetylpyridine adenine dinucleotide phosphate, an alkylating analogue of NADP+. An alkylating analogue of NADP+ the 3-chloroacetylpyridine adenine dinucleotide phosphate was prepared from 3-diazoacetylpyridine adenine dinucleotide phosphate which was obtained by enzymatic transglucosidation of NADP+. The 3-diaz... | [
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PMID:28790 | Testosterone-attenuated stereotype and hyperactivity induced by beta-phenylethylamine in pargyline-pretreated rats. | Testosterone pretreatment (1.0-4.0 mg/kg) attenuated, in a dose-response fashion, the induction of stereotyped behavior and hyperactivity by pargyline (0.25, 4.0 mg/kg) and beta-phenylethylamine (8.0, 16.0 mg/kg) in preubertal, male rats. The dyskinetic movements induced by pargyline and beta-phenylethylamine were prop... | Testosterone-attenuated stereotype and hyperactivity induced by beta-phenylethylamine in pargyline-pretreated rats. Testosterone pretreatment (1.0-4.0 mg/kg) attenuated, in a dose-response fashion, the induction of stereotyped behavior and hyperactivity by pargyline (0.25, 4.0 mg/kg) and beta-phenylethylamine (8.0, 16.... | [
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PMID:28794 | Bone marrow colony-forming cells in acute drug-induced agranulocytosis. | The capacity to differentiate and form colonies in vitro by bone marrow granulocytic precursor cells and its evolution were studied in eight cases of drug-induced acute agranulocytosis. In three cases colonies and clusters count were normal or high. These cases were probably immunological agranulocytosis. In the five o... | Bone marrow colony-forming cells in acute drug-induced agranulocytosis. The capacity to differentiate and form colonies in vitro by bone marrow granulocytic precursor cells and its evolution were studied in eight cases of drug-induced acute agranulocytosis. In three cases colonies and clusters count were normal or high... | [
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PMID:28795 | Immunological profile in sarcoidosis patients. The in vitro and in vivo effect of thymic humoral factor. | A study was made of the lymphocytes obtained from 25 patients suffering from sarcoidosis as proved by the Kveim-Siltzbach test and/or organ biopsy. The number of T lymphocytes was determined by the E rosette technique and functional activity by a local xenogeneic graft-versus-host reaction (GVHR) as well as skin tests ... | Immunological profile in sarcoidosis patients. The in vitro and in vivo effect of thymic humoral factor. A study was made of the lymphocytes obtained from 25 patients suffering from sarcoidosis as proved by the Kveim-Siltzbach test and/or organ biopsy. The number of T lymphocytes was determined by the E rosette techniq... | [
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PMID:28796 | Hydrogen ion CO2 and buffer capacity in brain from water depleted rats. | pH, C02 and buffer capacity of the brain and blood acid-base status were studied in (C) control and in acutely water depleted (WD) rats. WD rats developed a greater metabolic [H+] increase in brain than in blood. The results suggest that brain [H+] change is a primary metabolic reply to acute dehydration. | Hydrogen ion CO2 and buffer capacity in brain from water depleted rats. pH, C02 and buffer capacity of the brain and blood acid-base status were studied in (C) control and in acutely water depleted (WD) rats. WD rats developed a greater metabolic [H+] increase in brain than in blood. The results suggest that brain [H+]... | [
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PMID:28797 | Equilibrium and kinetics of the thermal unfolding of alpha-lactalbumin. The relation to its folding mechanism. | The thermal unfolding of alpha-lactalbumin has been studied by equilibrium measurements of aromatic difference spectra, and by kinetic measurements of the Joule heating temperature-jump. The unfolding at neutral pH is a reversible two-state transition. The equilibrium transition curves are analyzed by the nonlinear squ... | Equilibrium and kinetics of the thermal unfolding of alpha-lactalbumin. The relation to its folding mechanism. The thermal unfolding of alpha-lactalbumin has been studied by equilibrium measurements of aromatic difference spectra, and by kinetic measurements of the Joule heating temperature-jump. The unfolding at neutr... | [
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PMID:28798 | Continuous fractionation of human plasma. | Continuous processing has been applied to human plasma fractionation by the cold ethanol process. On-line pH control of +/- 0.05 pH units, flow control of +/- 1%, and temperature control of +/- 0.5 degree C have been achieved. Optimization of precipitation pHs has been carried out for purifying plasma protein fractions... | Continuous fractionation of human plasma. Continuous processing has been applied to human plasma fractionation by the cold ethanol process. On-line pH control of +/- 0.05 pH units, flow control of +/- 1%, and temperature control of +/- 0.5 degree C have been achieved. Optimization of precipitation pHs has been carried ... | [
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PMID:28799 | Toxic effects of fatty acids on yeast cells: possible mechanisms of action. | As shown in a previous paper, threshold concentrations of lower and intermediate fatty acids inhibit the uptake of inorganic phosphate, growth, and cell division in yeast cells. This demonstrates that, apart from these effects, the acids cause an increase in the respiration quotient (RQ), inhibition of CO2 fixation, pr... | Toxic effects of fatty acids on yeast cells: possible mechanisms of action. As shown in a previous paper, threshold concentrations of lower and intermediate fatty acids inhibit the uptake of inorganic phosphate, growth, and cell division in yeast cells. This demonstrates that, apart from these effects, the acids cause ... | [
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0.011918... |
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