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PMID:29354 | Teratogenic action of bis(dichloroacetyl)diamine on rats: patterns of malformations produced in high incidence at time-limited periods of development. | Win 18,446, a bis(dichloroacetyl)diamine, is a drug that was previously shown to suppress spermatogenesis and to be an effective oral abortifacient in rats. The present study shows that the drug is capable of producing characteristic congenital malformations in high incidence, by a single treatment, and with high survi... | Teratogenic action of bis(dichloroacetyl)diamine on rats: patterns of malformations produced in high incidence at time-limited periods of development. Win 18,446, a bis(dichloroacetyl)diamine, is a drug that was previously shown to suppress spermatogenesis and to be an effective oral abortifacient in rats. The present ... | [
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PMID:29357 | Stabilization of interferons. | It is now obvious that there are a number of factors which can influence the stability of interferons. Since human fibroblast interferon is especially unstable both to heat and mechanical stress, the use of stabilizing conditions such as low pH or thioctic acid should facilitate purification and concentration of this i... | Stabilization of interferons. It is now obvious that there are a number of factors which can influence the stability of interferons. Since human fibroblast interferon is especially unstable both to heat and mechanical stress, the use of stabilizing conditions such as low pH or thioctic acid should facilitate purificati... | [
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PMID:29362 | Study on dissolution and disintegration of calcium bilirubinate stone. | When a slice of calcium bilirubinate stone was incubated in a solution of tetrasodium salt of ethylendiamine-tetraacetic acid (EDTA.4Na), a potent chelating agent, the solution exhibited a yellow brown tint, which was spectroscopically characteristic of bilirubin. Microscopic examination of the slice revealed dissoluti... | Study on dissolution and disintegration of calcium bilirubinate stone. When a slice of calcium bilirubinate stone was incubated in a solution of tetrasodium salt of ethylendiamine-tetraacetic acid (EDTA.4Na), a potent chelating agent, the solution exhibited a yellow brown tint, which was spectroscopically characteristi... | [
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PMID:29367 | [Concentration of acid and basic proteins in the nuclei of hippocampal neurons and neuroglia of rat brain following elaboration of a passive avoidance conditioned reflex]. | By means of two-wave-length visible cytophotometry, the content of acidic and basic proteins per cell nucleus was shown to increase in CA3 hippocampal neurons only 3 hours after the learning session of conditioned reflex of passive avoidance. The protein content in the nuclei of perineuronal neuroglia cells of CA3 hipp... | [Concentration of acid and basic proteins in the nuclei of hippocampal neurons and neuroglia of rat brain following elaboration of a passive avoidance conditioned reflex]. By means of two-wave-length visible cytophotometry, the content of acidic and basic proteins per cell nucleus was shown to increase in CA3 hippocamp... | [
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PMID:29368 | [Enzymologic study of the structural organization of the matrix or rat liver peroxisomes]. | The effect of ionic strength and pH on the release of some enzymes of the matrix of peroxisomes in rat's liver was studied. Catalase, L ALpha-hydroxy acid oxidase, isocitrate dehydrogenase, glycerophosphate dehydrogenase and lactate dehydrogenase were easily released from the particles during their lysis and treatment ... | [Enzymologic study of the structural organization of the matrix or rat liver peroxisomes]. The effect of ionic strength and pH on the release of some enzymes of the matrix of peroxisomes in rat's liver was studied. Catalase, L ALpha-hydroxy acid oxidase, isocitrate dehydrogenase, glycerophosphate dehydrogenase and lact... | [
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PMID:29372 | [Acid-base state disorders and their correction in acute mesenteric vascular obstruction]. | The results of the investigation of main indices of acid-base equilibrium in 28 patients with acute obstruction of the mesenteric vessels are set forth. 12 patients out of 28 developed subcompensated or decompensated metabolic acidosis. The authors believe that the correction of acid-base equilibrium disorders is an ef... | [Acid-base state disorders and their correction in acute mesenteric vascular obstruction]. The results of the investigation of main indices of acid-base equilibrium in 28 patients with acute obstruction of the mesenteric vessels are set forth. 12 patients out of 28 developed subcompensated or decompensated metabolic ac... | [
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PMID:29379 | Absorption of the beta-adrenergic-blocking agent, nadolol, by mice, rats, hamsters, rabbits, dogs, monkeys, and man: an unusual species difference. | 1. Dogs absorbed [14C]nadolol almost completely (88--104%) after oral administration of 10--75 mg/kg. In contrast, mice, rats, hamsters, and rabbits, given oral doses of 20 mg/kg, absorbed, at most, 25%. After administration of oral doses of 2--75 mg/kg, monkeys absorbed no more than an average of 30%. Six monkeys give... | Absorption of the beta-adrenergic-blocking agent, nadolol, by mice, rats, hamsters, rabbits, dogs, monkeys, and man: an unusual species difference. 1. Dogs absorbed [14C]nadolol almost completely (88--104%) after oral administration of 10--75 mg/kg. In contrast, mice, rats, hamsters, and rabbits, given oral doses of 20... | [
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PMID:29380 | Glutamate metabolism in a monokaryon of Coprinus cinereus. | The possible involvement of the glutamine synthetase/glutamate synthase pathway in ammonia assimilation is reported in a monokaryon of Coprinus cinereus. | Glutamate metabolism in a monokaryon of Coprinus cinereus. The possible involvement of the glutamine synthetase/glutamate synthase pathway in ammonia assimilation is reported in a monokaryon of Coprinus cinereus. | [
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PMID:29381 | Microbial biodegradation of cellophase. | The microbial biodegradation of cellophane (U.C.B.--Division Sidac) was studied. Preliminary experiments with pure cultures of seven cellulolytic microorganisms (Aspergillus sp., Penicillium sp., Chaetomium crispatum, Ch. globosum, Sclerotium rolfsii and two actinomycetes) revealed that the substrate as such was very r... | Microbial biodegradation of cellophase. The microbial biodegradation of cellophane (U.C.B.--Division Sidac) was studied. Preliminary experiments with pure cultures of seven cellulolytic microorganisms (Aspergillus sp., Penicillium sp., Chaetomium crispatum, Ch. globosum, Sclerotium rolfsii and two actinomycetes) reveal... | [
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PMID:29386 | Kinetic studies on the formation of nitrosamines I. Formation of dimethylnitrosamine in aqeous solution of perchloric acid. | The kinetics of nitrosation of dimethylamine (DMA) in aqueous perchloric acid solution have been studied using a differential spectrophotometric technique. The rate law is Initial rate = e[DMA]0 [nitrite]2 0 [H+]/(f + [H+])2 where [DMA]0 and [nitrite]0 represent initial stoichiometric concentrations. At 310.0 K and mu ... | Kinetic studies on the formation of nitrosamines I. Formation of dimethylnitrosamine in aqeous solution of perchloric acid. The kinetics of nitrosation of dimethylamine (DMA) in aqueous perchloric acid solution have been studied using a differential spectrophotometric technique. The rate law is Initial rate = e[DMA]0 [... | [
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PMID:29388 | Pyruvate and citrate metabolism in the muscle tissue of Ascaris lumbricoides. | Aconitase and NAD linked isocitrate dehydrogenase were present in Ascaris lumbricoides muscle at only very low activities, whilst there were significant levels of citrate synthase, NADP linked isocitrate dehydrogenase, 2-oxoglutarate dehydrogenase and succinic thiokinase. Pyruvate dehydrogenase was present in A. lumbri... | Pyruvate and citrate metabolism in the muscle tissue of Ascaris lumbricoides. Aconitase and NAD linked isocitrate dehydrogenase were present in Ascaris lumbricoides muscle at only very low activities, whilst there were significant levels of citrate synthase, NADP linked isocitrate dehydrogenase, 2-oxoglutarate dehydrog... | [
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PMID:29389 | Investigations into the free-living phase of the cat hookworm life cycle. | Laboratory studies were undertaken to evaluate the role of environmental factors on the development of free-living stages of the cat hookworm Ancylostoma tubaeforme. An index of development calculated from the proportion of eggs that developed to the infective stage and the reciprocal of the development period, has sug... | Investigations into the free-living phase of the cat hookworm life cycle. Laboratory studies were undertaken to evaluate the role of environmental factors on the development of free-living stages of the cat hookworm Ancylostoma tubaeforme. An index of development calculated from the proportion of eggs that developed to... | [
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PMID:29398 | [Japanese methods of psychotherapy and their socio-cultural determinants. Impressions from Japan together with a report on the IV Congress of the International College of Psychosomatic Medicine, Sept. 5--9, 1977 in Kyoto]. | Impressions of a congress-visiting-journey through the highly-industrialized far-east Japan are the background for description of specific Japanese Psychotherapeutic-technics f.i.: the Morita-therapy, Naikan-therapy and the Fasten-therapy. To the analytically trained Psychosomatic-specialist of western mentality those ... | [Japanese methods of psychotherapy and their socio-cultural determinants. Impressions from Japan together with a report on the IV Congress of the International College of Psychosomatic Medicine, Sept. 5--9, 1977 in Kyoto]. Impressions of a congress-visiting-journey through the highly-industrialized far-east Japan are t... | [
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PMID:29417 | Factors affecting the microbial and chemical composition of silage. III. Effect of urea additions on maize silage. | The effect of urea additions on the microbiological and chemical properties of silage, produced from young maize plants (Darawa stage), was studied. Urea treatments, i.e., 0.25%, 0.50%, 0.75%, and 1.00%, stimulated higher densities of the desired microorganisms than the control, while undesired organisms showed lower c... | Factors affecting the microbial and chemical composition of silage. III. Effect of urea additions on maize silage. The effect of urea additions on the microbiological and chemical properties of silage, produced from young maize plants (Darawa stage), was studied. Urea treatments, i.e., 0.25%, 0.50%, 0.75%, and 1.00%, s... | [
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PMID:29418 | Serum-albumin agar used as slant for the differentiation between Trichophyton rubrum and Trichophyton mentagrophytes: specific reg pigmentation of T. rubrum. | Trichophyton rubrum strains freshly isolated from clinical material exhibited red pigment formation within 7 days at 26 degrees C on slant serum-albumin agar, initial pH 7.0. In Trichophyton mentagrophytes strains this phenomenon could not be observed. Since in the case of T. rubrum, yellow pigmentation will appear at ... | Serum-albumin agar used as slant for the differentiation between Trichophyton rubrum and Trichophyton mentagrophytes: specific reg pigmentation of T. rubrum. Trichophyton rubrum strains freshly isolated from clinical material exhibited red pigment formation within 7 days at 26 degrees C on slant serum-albumin agar, ini... | [
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PMID:29419 | [Neurologic syndromes in myocardial infarct patients during various stages of treatment]. | The clinical picture of myocardial infarctions in complicated and manifold. A clinico-physiological analysis of neurological disorders gives ground to consider that in myocardial infarctions the process of irritation involves the peripheral vegetative apparatus and spinal segmental structures, as well as the hypothalmo... | [Neurologic syndromes in myocardial infarct patients during various stages of treatment]. The clinical picture of myocardial infarctions in complicated and manifold. A clinico-physiological analysis of neurological disorders gives ground to consider that in myocardial infarctions the process of irritation involves the ... | [
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PMID:29420 | The action of cathepsin B and collagenolytic cathepsin in the degradation of collagen. | Cathepsin B and collagenolytic cathepsin were obtained from bovine spleen and human placenta and identified as thiol proteinases. Both enzymes degraded insoluble fibrous collagen maximally at pH 3.5 and soluble monomeric collagen near pH 4.5. The response to activators and inhibitors was similar for both enzymes. Colla... | The action of cathepsin B and collagenolytic cathepsin in the degradation of collagen. Cathepsin B and collagenolytic cathepsin were obtained from bovine spleen and human placenta and identified as thiol proteinases. Both enzymes degraded insoluble fibrous collagen maximally at pH 3.5 and soluble monomeric collagen nea... | [
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PMID:29424 | Reduced post-natal rise of testosterone in plasma of cryptorchid infants. | Plasma testosterone has been studied in 31 full-term male infants born with bilaterally undescended testes (14) or unilaterally undescended testis (17). From 10 to 89 days after birth, the post-natal testosterone rise was significantly lower in the 18 infants who remained cryptorchid at 4 months than in the 13 who unde... | Reduced post-natal rise of testosterone in plasma of cryptorchid infants. Plasma testosterone has been studied in 31 full-term male infants born with bilaterally undescended testes (14) or unilaterally undescended testis (17). From 10 to 89 days after birth, the post-natal testosterone rise was significantly lower in t... | [
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PMID:29425 | In vitro and in vivo studies on Leydig cell function in old rats. | Young adult (3 months old) and old (26-28 months old) male Wistar rats were studied. Testicular weight was 1.66 g (range: 1.33--2.86) in the younger group and 1.62 g (range: 1.04--1.90) in the older group. The total Leydig cell volume as measured by a quantitative histometric method was significantly larger in the old ... | In vitro and in vivo studies on Leydig cell function in old rats. Young adult (3 months old) and old (26-28 months old) male Wistar rats were studied. Testicular weight was 1.66 g (range: 1.33--2.86) in the younger group and 1.62 g (range: 1.04--1.90) in the older group. The total Leydig cell volume as measured by a qu... | [
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PMID:29430 | Influence of "lytic cocktail" on blood flow and oxygen consumption in the rat brain. | The influence of a sedative dose of "lytic cocktail" (chlorpromazine, promethazine and pethidine) on cerebral blood flow (CBF) and oxygen consumjtion (CMRO2) was tested in artificially ventilated rats, maintained on either 70% N2 or 70% N2O. When given alone, the lytic cocktail had no significant effect on CBF or CMRO2... | Influence of "lytic cocktail" on blood flow and oxygen consumption in the rat brain. The influence of a sedative dose of "lytic cocktail" (chlorpromazine, promethazine and pethidine) on cerebral blood flow (CBF) and oxygen consumjtion (CMRO2) was tested in artificially ventilated rats, maintained on either 70% N2 or 70... | [
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PMID:29431 | tcPCO2 electrode design, calibration and temperature gradient problems. | Transcutaneous PCO2 electrodes habe been constructed and evaluated on adults and children. Glass pH and silver reference electrodes were used at 44--45 degrees C, with either circulating water and a copper jacket, or with internal electrical heating. The skin surface PCO2 at 44 degrees C is about 1.33 times PaCO2 plus ... | tcPCO2 electrode design, calibration and temperature gradient problems. Transcutaneous PCO2 electrodes habe been constructed and evaluated on adults and children. Glass pH and silver reference electrodes were used at 44--45 degrees C, with either circulating water and a copper jacket, or with internal electrical heatin... | [
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PMID:29432 | Low impedance pH sensitive electrochemical devices that are potentially applicable to transcutaneous PCO2 measurements. | Two cases of low impedance, non-glass membrane electrodes for pH measurement were evaluated: (I) Metal--metal oxide electrodes and (II) Reduction-oxidation electrodes. The fundamental cause of oxygen sensitivity of metal-metal oxide electrodes were examined and three approaches for its suppression were proposed. For th... | Low impedance pH sensitive electrochemical devices that are potentially applicable to transcutaneous PCO2 measurements. Two cases of low impedance, non-glass membrane electrodes for pH measurement were evaluated: (I) Metal--metal oxide electrodes and (II) Reduction-oxidation electrodes. The fundamental cause of oxygen ... | [
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PMID:29437 | The effects of isoproterenol on fetal oxygenation. | Infusion of isoproterenol (1 microgram/kg/min, i.v.) into the anesthetized pregnant rhesus monkey near term consistently reduced fetal oxygenation, despite diminishing myometrial activity. The decline in pO2 of fetal arterial blood (mean = 4.3 +/- 2.3 mmHg S.D.) was accompanied by an increase in pCO2 tension (mean = 4.... | The effects of isoproterenol on fetal oxygenation. Infusion of isoproterenol (1 microgram/kg/min, i.v.) into the anesthetized pregnant rhesus monkey near term consistently reduced fetal oxygenation, despite diminishing myometrial activity. The decline in pO2 of fetal arterial blood (mean = 4.3 +/- 2.3 mmHg S.D.) was ac... | [
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PMID:29438 | Glaucoma treatment with timolol. | Thirty-two eyes from 19 patients with either capsular glaucoma, pigmentary glaucoma or primary open angle glaucoma were given topical timolol and followed through a 3--6 months period. Twelve eyes were previously out of control on full medication including pilocarpine, epinephrine and acetazolamide. Eight of these eyes... | Glaucoma treatment with timolol. Thirty-two eyes from 19 patients with either capsular glaucoma, pigmentary glaucoma or primary open angle glaucoma were given topical timolol and followed through a 3--6 months period. Twelve eyes were previously out of control on full medication including pilocarpine, epinephrine and a... | [
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PMID:29439 | Microcalorimetric study of the effects of cephalexin and cephaloridin on Escherichia coli and Staphylococcus aureus. | The kinetics of the antibacterial actions of cephalexin and cephaloridin against a strain of Escherichia coli and a strain of Staphylococcus aureus were studied by a flow microcalorimeter. The heat production was related to the number of viable organisms (CFU ml-1), the pH, the optical density of the culture medium (OD... | Microcalorimetric study of the effects of cephalexin and cephaloridin on Escherichia coli and Staphylococcus aureus. The kinetics of the antibacterial actions of cephalexin and cephaloridin against a strain of Escherichia coli and a strain of Staphylococcus aureus were studied by a flow microcalorimeter. The heat produ... | [
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PMID:29440 | Studies on calcium uptake by myometrial microsomes with particular reference to the dependence on inorganic phosphate and oxalate. | Ca uptake by microsomes isolated from non-pregnant rabbit myometrium was potentiated by both inorganic phosphate (Pi) and oxalate anions. Both Pi and oxalate had little effect on the initial rate of uptake but a pronounced effect on the capacity of Ca uptake measured after 20 min which was greater in the presence of ox... | Studies on calcium uptake by myometrial microsomes with particular reference to the dependence on inorganic phosphate and oxalate. Ca uptake by microsomes isolated from non-pregnant rabbit myometrium was potentiated by both inorganic phosphate (Pi) and oxalate anions. Both Pi and oxalate had little effect on the initia... | [
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PMID:29441 | A controlled long-term study of flunitrazepam, nitrazepam and placebo, with special regard to withdrawal effects. | The hypnotic effect of flunitrazepam (Ro 5-4200), nitrazepam and a placebo was studied in 117 outpatients using hypnotics for at least 3 months prior to the study. They obtained various neurotropic drugs and this and other treatments were unchanged throughout the trial period of 13 weeks. This consisted of 3 weeks on t... | A controlled long-term study of flunitrazepam, nitrazepam and placebo, with special regard to withdrawal effects. The hypnotic effect of flunitrazepam (Ro 5-4200), nitrazepam and a placebo was studied in 117 outpatients using hypnotics for at least 3 months prior to the study. They obtained various neurotropic drugs an... | [
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PMID:29442 | Demonstration of enzymatic activity converting azathioprine to 6-mercaptopurine. | The enzymatic conversion of azathioprine to 6-mercaptopurine was detected at pH 6.5 with rat liver supernatants, although the non-enzymatic reaction predominated at pH 7.0 and 7.5. Glutathione S-transferase may catalize this conversion. Activities of the enzyme in liver with both zathioprine and 1,2-dichloro-4-nitroben... | Demonstration of enzymatic activity converting azathioprine to 6-mercaptopurine. The enzymatic conversion of azathioprine to 6-mercaptopurine was detected at pH 6.5 with rat liver supernatants, although the non-enzymatic reaction predominated at pH 7.0 and 7.5. Glutathione S-transferase may catalize this conversion. Ac... | [
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PMID:29447 | Transmitters for the afferent and efferent systems of the neostriatum and their possible interactions. | The surgical denervation techniques have been widely employed as a tool to identify the neuronal origin of various neurotransmitters in the basal ganglia. Besides the well known nigrostriatal dopaminergic pathway, there is a high glutamic acid-containing corticostriatal connection and the cholinergic thalamostriatal pr... | Transmitters for the afferent and efferent systems of the neostriatum and their possible interactions. The surgical denervation techniques have been widely employed as a tool to identify the neuronal origin of various neurotransmitters in the basal ganglia. Besides the well known nigrostriatal dopaminergic pathway, the... | [
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PMID:29455 | Enzymic studies on glial and neuronal cells during myelination. | The formation of ethanolamine plasmalogen from labelled 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine was studied in neurons and glial cells of the developing rat brain. It was found that the conversion of the ether to the enol-ether bond of the 1-alkyl moiety by the neuronal and glial desaturase system requires u... | Enzymic studies on glial and neuronal cells during myelination. The formation of ethanolamine plasmalogen from labelled 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine was studied in neurons and glial cells of the developing rat brain. It was found that the conversion of the ether to the enol-ether bond of the 1-alk... | [
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PMID:29457 | Interaction between PCO2 and plasma [HCO-3] in regulation of CSF [HCO-3] in respiratory alkalosis and metabolic acidosis. | The results of studies presented may be interpreted in light of the dual contribution theory of regulation of CSF acid-base balance, indicating significant interaction between systemic and local CNS mechanisms in H+ homeostasis in the brain and CSF. Both systemic and local mechanisms are at work in H+ homeostasis in th... | Interaction between PCO2 and plasma [HCO-3] in regulation of CSF [HCO-3] in respiratory alkalosis and metabolic acidosis. The results of studies presented may be interpreted in light of the dual contribution theory of regulation of CSF acid-base balance, indicating significant interaction between systemic and local CNS... | [
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PMID:29464 | Conditions for production of thermosensitive attenuated influenza virus recombinants. | Recombination and cross-reactivation between virulent influenza viruses and a cold-adapted thermosensitive vaccine strain regularly produced genetically stable attenuated recombinants, the selection of which was based on the thermosensitivity marker. This marker, correlating with the safety of the recombinants for man ... | Conditions for production of thermosensitive attenuated influenza virus recombinants. Recombination and cross-reactivation between virulent influenza viruses and a cold-adapted thermosensitive vaccine strain regularly produced genetically stable attenuated recombinants, the selection of which was based on the thermosen... | [
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PMID:29465 | Interspecies interactions of arboviruses. III. Competition for virus envelope antigens in mixed Getah and Sindbis virus populations. | Interactions of Getah and Sindbis virus populations in mixed infections of 5 tissue systems were competitive or neutral. The type of interaction is regulated by the host cell and virus population density. On reproduction in mouse brains and SPEV cell cultures the mixed population exhibited antigenic markers of Getah vi... | Interspecies interactions of arboviruses. III. Competition for virus envelope antigens in mixed Getah and Sindbis virus populations. Interactions of Getah and Sindbis virus populations in mixed infections of 5 tissue systems were competitive or neutral. The type of interaction is regulated by the host cell and virus po... | [
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PMID:29466 | Experimental pathogenesis of non-lethal herpesvirus infection and the establishment of latency. | In rabbits inoculated into the right scarified cornea with the Kupka strain of human Herpesvirus type 1 (HHV 1), healing of the keratitis occurred between days 8--12 post infection (p.i.). Viral particles were seen in nuclei and cytoplasm of corneal epithelium cells and in a few fibrocytes of corneal stroma. By immunof... | Experimental pathogenesis of non-lethal herpesvirus infection and the establishment of latency. In rabbits inoculated into the right scarified cornea with the Kupka strain of human Herpesvirus type 1 (HHV 1), healing of the keratitis occurred between days 8--12 post infection (p.i.). Viral particles were seen in nuclei... | [
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PMID:29467 | Antiviral activity of dipyridamole derivatives. | Among 46 novel pyrimido [5.4-d] pyrimidine derivatives, 26 compounds were found to exhibit antiviral activity as revealed in a test programme against Mengo, Coxsackie B1, fowl plague, vaccinia and pseudorabies viruses, as concerns inhibition of plaque formation and of infectious virus yield. Attempts to disclose struct... | Antiviral activity of dipyridamole derivatives. Among 46 novel pyrimido [5.4-d] pyrimidine derivatives, 26 compounds were found to exhibit antiviral activity as revealed in a test programme against Mengo, Coxsackie B1, fowl plague, vaccinia and pseudorabies viruses, as concerns inhibition of plaque formation and of inf... | [
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PMID:29468 | Isolation of influenza virus from wild ducks (Anas platyrhynchos). | In the course of studies on influenza virus ecology, Influenzavirus A was isolated from a cloacal smear from a wild duck (Anas platyrhynchos) caught in west Slovakia. The strain was identified as A(Hav7Nav1). The results of virus isolation experiments from other species of aquatic and other small birds were negative. | Isolation of influenza virus from wild ducks (Anas platyrhynchos). In the course of studies on influenza virus ecology, Influenzavirus A was isolated from a cloacal smear from a wild duck (Anas platyrhynchos) caught in west Slovakia. The strain was identified as A(Hav7Nav1). The results of virus isolation experiments f... | [
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PMID:29469 | Influence of mild acid hydrolysis on the antigenic properties of phase I Coxiella burnetii. | Mild acid hydrolysis of phase I Coxiella burnetii cells gradually cleaved off polysaccharide chains, which contain determinants of antigen 1, thus unmasking determinants of the diagnostically important antigen 2. This artificial phase I to phase II conversion was reflected by changed serological activity in the complem... | Influence of mild acid hydrolysis on the antigenic properties of phase I Coxiella burnetii. Mild acid hydrolysis of phase I Coxiella burnetii cells gradually cleaved off polysaccharide chains, which contain determinants of antigen 1, thus unmasking determinants of the diagnostically important antigen 2. This artificial... | [
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PMID:29470 | Immunological properties of the lipopolysaccharide-protein complex of Coxiella burnetii. | Purified lipopolysaccharide-protein complex (LPS-PC) extracted by trichloroacetic acid from phase I Coxiella burnetii organisms induced in mice and rabbits fair levels of antibodies directed to antigen 1 and antigen 2, as detected by complement-fixation (CF), microagglutination (MA), opsonization-phagocytosis (OP) and ... | Immunological properties of the lipopolysaccharide-protein complex of Coxiella burnetii. Purified lipopolysaccharide-protein complex (LPS-PC) extracted by trichloroacetic acid from phase I Coxiella burnetii organisms induced in mice and rabbits fair levels of antibodies directed to antigen 1 and antigen 2, as detected ... | [
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PMID:29471 | Cytomegalovirus infections in the human population. | Diagnostic and clinical experience gained in the period from 1966--1977 is summarized. Cytomegalovirus was isolated from 35 sucklings and 5 infants aged more than 1 year as well as from necropsy materials from 10 sucklings. The most frequently involved were the respiratory tract (77.8%), liver (53.5%) and haematopoetic... | Cytomegalovirus infections in the human population. Diagnostic and clinical experience gained in the period from 1966--1977 is summarized. Cytomegalovirus was isolated from 35 sucklings and 5 infants aged more than 1 year as well as from necropsy materials from 10 sucklings. The most frequently involved were the respir... | [
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PMID:29472 | Strain differences in electrophoretic mobility of influenzavirus A polypeptides. | Slab polyacrylamide gel electrophoresis of Influenza-virus A strains varying in antigenic composition of the envelope and in the natural host species showed the nucleprotein and membrane proteins to have a standard molecular weight of 58,000 and 24,000 daltons, respectively. The electrophoretic mobility and molecular w... | Strain differences in electrophoretic mobility of influenzavirus A polypeptides. Slab polyacrylamide gel electrophoresis of Influenza-virus A strains varying in antigenic composition of the envelope and in the natural host species showed the nucleprotein and membrane proteins to have a standard molecular weight of 58,0... | [
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PMID:29473 | Isolation of encephalomyocarditis virus from the pheasant (Phasianus colchicus) in Czechoslovakia. | The first isolation of encephalomyocarditis (EMC) virus from the blood and brain of a pheasant (Phasianus colchicus) captured in Moravia is reported. Complement-fixation (CF) tests with reference antisera revealed no relationship to any of a wide range of known arboviruses. | Isolation of encephalomyocarditis virus from the pheasant (Phasianus colchicus) in Czechoslovakia. The first isolation of encephalomyocarditis (EMC) virus from the blood and brain of a pheasant (Phasianus colchicus) captured in Moravia is reported. Complement-fixation (CF) tests with reference antisera revealed no rela... | [
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PMID:29474 | Sensitivity of formation of adenovirus specific tumour antigen to leukocyte interferon. | The effect of various concentrations of chicken leukocyte interferon was examined on the expression of adenovirus tumour (T) antigen in chick embryo cells. The inhibition of T antigen formation was dependent on the multiplicity of infection. The reduction of T antigen-producing cells was greater when interferon was app... | Sensitivity of formation of adenovirus specific tumour antigen to leukocyte interferon. The effect of various concentrations of chicken leukocyte interferon was examined on the expression of adenovirus tumour (T) antigen in chick embryo cells. The inhibition of T antigen formation was dependent on the multiplicity of i... | [
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PMID:29475 | Rates of infection in, and transmission of, African horse-sickness virus by Aedes aegypti mosquitoes. | Very low infection rates (less than 3%) were obtained when Aedes aegypti mosquitoes ingested blood contained 5.8--6.5 log10 MLD50/0.02 ml African horse sickness virus (AHSV). When A. aegypti mosquitoes were inoculated intrathoracically with virus, however, high infection rates were achieved. Mosquitoes infected by inoc... | Rates of infection in, and transmission of, African horse-sickness virus by Aedes aegypti mosquitoes. Very low infection rates (less than 3%) were obtained when Aedes aegypti mosquitoes ingested blood contained 5.8--6.5 log10 MLD50/0.02 ml African horse sickness virus (AHSV). When A. aegypti mosquitoes were inoculated ... | [
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PMID:29476 | Rickettsiella phytoseiuli and virus-like particles in Phytosfiulus persimilis (Gamasoidea: Phytoseiidae) mites. | Electron microscope investigation of tissue of Phytoseiulus persimilis mites revealed its double infection with Rickettsiella phytoseiuli and virus-like particles. The presence of rickettsiae in tissues of the mite seemed to be decisive for establishment of virus infection. | Rickettsiella phytoseiuli and virus-like particles in Phytosfiulus persimilis (Gamasoidea: Phytoseiidae) mites. Electron microscope investigation of tissue of Phytoseiulus persimilis mites revealed its double infection with Rickettsiella phytoseiuli and virus-like particles. The presence of rickettsiae in tissues of th... | [
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PMID:29477 | Cross reactions among flaviviruses in macrophage migration inhibition assay. | Adult Swiss albino mice were immunized intravenously with flaviviviruses. Cellular immune response was studied by macrophage migration inhibition assay. Migration of cells from sensitized mice was significantly inhibited in the presence of homologous virus or antigen. Migration inhibition was also significant with sero... | Cross reactions among flaviviruses in macrophage migration inhibition assay. Adult Swiss albino mice were immunized intravenously with flaviviviruses. Cellular immune response was studied by macrophage migration inhibition assay. Migration of cells from sensitized mice was significantly inhibited in the presence of hom... | [
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PMID:29480 | Methodical aspects of the experimental chemotherapy of viral infections. | An analysis of the methods of testing the antiviral activity in vitro (in cell cultures) and in vivo (in experimental virus infections) is presented. The necessity of applying two-stage screening in vitro is emphasized. The chemotherapeutic viral models is in vitro testing as well as the principles of modelling of expe... | Methodical aspects of the experimental chemotherapy of viral infections. An analysis of the methods of testing the antiviral activity in vitro (in cell cultures) and in vivo (in experimental virus infections) is presented. The necessity of applying two-stage screening in vitro is emphasized. The chemotherapeutic viral ... | [
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PMID:29481 | The theoretical implications of chlorpromazine as a sensory integrative theory. | In order to evaluate the influence of antipsychotic drugs used in the treatment of schizophrenia on therapy based on sensory integrative theory, this study, developed through library research, explores the theoretical bases for these two modes of treatment. Studies of chlorpromazine, a prototypical antipsychotic drug, ... | The theoretical implications of chlorpromazine as a sensory integrative theory. In order to evaluate the influence of antipsychotic drugs used in the treatment of schizophrenia on therapy based on sensory integrative theory, this study, developed through library research, explores the theoretical bases for these two mo... | [
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PMID:29482 | Arterial hypoxemia following the administration of sublingual nitroglycerin. | The effect of nitroglycerin on arterial blood gases and cardiovascular hemodynamics were studied in patients with coronary artery disease. In 13 premedicated patients blood gases and cardiovascular hemodynamics were studied before and 10 minutes after sublingual nitroglycerin (0.6 mg). In eight unpremedicated patients ... | Arterial hypoxemia following the administration of sublingual nitroglycerin. The effect of nitroglycerin on arterial blood gases and cardiovascular hemodynamics were studied in patients with coronary artery disease. In 13 premedicated patients blood gases and cardiovascular hemodynamics were studied before and 10 minut... | [
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PMID:29483 | Evaluation of the counterimmunoelectrophoretic (CIE) procedure in a clinical laboratory setting. | The counterimmunoelectrophoretic (CIE) procedure was evaluated under clinical laboratory conditions to determine its validity and comparability with culture methods. The procedure was further evaluated to determine applicability to a variety of clinical samples. An inexpensive set-up was developed to utilize the CIE pr... | Evaluation of the counterimmunoelectrophoretic (CIE) procedure in a clinical laboratory setting. The counterimmunoelectrophoretic (CIE) procedure was evaluated under clinical laboratory conditions to determine its validity and comparability with culture methods. The procedure was further evaluated to determine applicab... | [
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PMID:29485 | Analysis of hydroxyzine hydrochloride, meperidine hydrochloride and atropine sulfate in glass and plastic syringes. | The apparent stability of combinations of hydroxyzine hydrochloride and meperidine hydrochloride (50 mg/2 ml each) and of these two drugs (50 mg/2.5 ml each) and atropine sulfate (0.4 mg/2.5 ml) in prefilled glass and plastic syringes was studied. Syringes (3 ml) containing the combinations were stored at 25 C and 3 C ... | Analysis of hydroxyzine hydrochloride, meperidine hydrochloride and atropine sulfate in glass and plastic syringes. The apparent stability of combinations of hydroxyzine hydrochloride and meperidine hydrochloride (50 mg/2 ml each) and of these two drugs (50 mg/2.5 ml each) and atropine sulfate (0.4 mg/2.5 ml) in prefil... | [
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PMID:29487 | Education and integration of midlevel health-care practitioners in obstetrics and gynecology: experience of a training program in Washington state. | The impetus for the development of the Gynecorps Training Program was the identification of medically underserved populations of women in Washington State and their need for preventive health care, the maldistribution of physicians, and the success of a pilot program for training midlevel personnel conducted in 1972 by... | Education and integration of midlevel health-care practitioners in obstetrics and gynecology: experience of a training program in Washington state. The impetus for the development of the Gynecorps Training Program was the identification of medically underserved populations of women in Washington State and their need fo... | [
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PMID:29488 | Amino acid transport in diaphragms from newborn rats: evidence for insulin resistance. | Diaphragms from rats under 24-h-old did not show the well-known increased transport of alpha-aminoisobutyrate found in older tissues in respone to insulin in vitro. A small effect was apparent by 3 days, and stimulation increased as donor rats aged (up to 4--5 wk). One-day diaphragms also had greater uptake than older ... | Amino acid transport in diaphragms from newborn rats: evidence for insulin resistance. Diaphragms from rats under 24-h-old did not show the well-known increased transport of alpha-aminoisobutyrate found in older tissues in respone to insulin in vitro. A small effect was apparent by 3 days, and stimulation increased as ... | [
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PMID:29490 | Characterization of distal hydrogen ion secretion in acute respiratory alkalosis. | The effect of acute respiratory alkalosis (ARA) on distal nephron H+ secretion was evaluated by measuring urine-to-blood (U-B) Pco2 in dogs with highly alkaline urine (urine pH greater than 7.8). ARA led to a significant decrease in U-B Pco2 and in urine HCO3 concentration; urine pH, however, increased significantly, i... | Characterization of distal hydrogen ion secretion in acute respiratory alkalosis. The effect of acute respiratory alkalosis (ARA) on distal nephron H+ secretion was evaluated by measuring urine-to-blood (U-B) Pco2 in dogs with highly alkaline urine (urine pH greater than 7.8). ARA led to a significant decrease in U-B P... | [
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PMID:29491 | Differences in inducibility by glucocorticoids of rat liver TO and TAT. | The modulation of tryptophan-oxygenase (TO) and tyrosine amino-transferase (TAT) in the rat liver after a single dose of hydrocortisone has been studied under various physiological conditions. Differences in the induction behavior of the two enzymes have been observed dependent on sex, age, amount of administered hormo... | Differences in inducibility by glucocorticoids of rat liver TO and TAT. The modulation of tryptophan-oxygenase (TO) and tyrosine amino-transferase (TAT) in the rat liver after a single dose of hydrocortisone has been studied under various physiological conditions. Differences in the induction behavior of the two enzyme... | [
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PMID:29492 | Ammonia metabolism. | The pathways responsible for an the mechanisms underlying the adaptive increase in ammonia production in response to acidosis are considered. It seems unlikely that the cytosolic pathways (glutamine synthetase, glutaminase II, phosphate-independent glutaminase, and gamma-glutamyl transferase) are of primary importance ... | Ammonia metabolism. The pathways responsible for an the mechanisms underlying the adaptive increase in ammonia production in response to acidosis are considered. It seems unlikely that the cytosolic pathways (glutamine synthetase, glutaminase II, phosphate-independent glutaminase, and gamma-glutamyl transferase) are of... | [
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PMID:29493 | Changes in the plasma anion gap during chronic metabolic acid-base disturbances. | A basic premise in the utilization of the plasma anion gap in the assessment of acid-base disorders is that this parameter remains constant during hyperchloremic metabolic acidosis and metabolic alkalosis. Experimental data under in vitro conditions, however, cast serious doubt on this premise. The purpose of the prese... | Changes in the plasma anion gap during chronic metabolic acid-base disturbances. A basic premise in the utilization of the plasma anion gap in the assessment of acid-base disorders is that this parameter remains constant during hyperchloremic metabolic acidosis and metabolic alkalosis. Experimental data under in vitro ... | [
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PMID:29495 | Relationship between blood pH and potassium and phosphorus during acute metabolic acidosis. | Metabolic acidosis is known to be associated with increased blood potassium and phosphorus concentrations but the influence of mineral versus nonmineral acids on these variables remains undefined. Therefore, we infused anesthetized mongrel dogs with 0.45% saline (controls), the mineral acids HCl and NH4Cl, and the nonm... | Relationship between blood pH and potassium and phosphorus during acute metabolic acidosis. Metabolic acidosis is known to be associated with increased blood potassium and phosphorus concentrations but the influence of mineral versus nonmineral acids on these variables remains undefined. Therefore, we infused anestheti... | [
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PMID:29496 | Marijuana use in schizophrenia: a clear hazard. | The use of marijuana as the independent variable produced a serious exacerbation of a psychotic process in four schizophrenic patients whose illness was otherwise well controlled with antipsychotic medication. Each patient served as his own control--the sole substance abused was marijuana and antipsychotic medication i... | Marijuana use in schizophrenia: a clear hazard. The use of marijuana as the independent variable produced a serious exacerbation of a psychotic process in four schizophrenic patients whose illness was otherwise well controlled with antipsychotic medication. Each patient served as his own control--the sole substance abu... | [
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PMID:29500 | Current medication use and symptoms of depression in a general population. | In a community survey, 41.8% of 771 men and 60.2% of 1,059 women reported having used one or more medications in the 48 hours before the interview. The use of medications and the number of medications used increased progressively with age among both men and women. Respondents who used four or more medications included ... | Current medication use and symptoms of depression in a general population. In a community survey, 41.8% of 771 men and 60.2% of 1,059 women reported having used one or more medications in the 48 hours before the interview. The use of medications and the number of medications used increased progressively with age among ... | [
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PMID:29501 | Psychotropic drugs, summer heat and humidity, and hyperpyrexia: a danger restated. | The authors note an apparent unawareness of, as well as a paucity of recent literature pertaining to, hyperpyrexia as a complication of psychotropic drug treatment. They report a case of hyperpyrexia in a patient receiving psychotropic agents during a summer heat wave; massive muscle destruction (rhabdomyolysis) with m... | Psychotropic drugs, summer heat and humidity, and hyperpyrexia: a danger restated. The authors note an apparent unawareness of, as well as a paucity of recent literature pertaining to, hyperpyrexia as a complication of psychotropic drug treatment. They report a case of hyperpyrexia in a patient receiving psychotropic a... | [
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PMID:29502 | Simple, effective treatment of agoraphobia. | For effective treatment of agoraphobia both patient and therapist must understand the mechanisms of sensitization and self-desensitization. Rather than aiming to adapt to difficult situations, to achieve desensitization by suggestions, or to avoid panic, the agoraphobe must learn to pass through panic and to rid onesel... | Simple, effective treatment of agoraphobia. For effective treatment of agoraphobia both patient and therapist must understand the mechanisms of sensitization and self-desensitization. Rather than aiming to adapt to difficult situations, to achieve desensitization by suggestions, or to avoid panic, the agoraphobe must l... | [
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PMID:29504 | Changes of glycosaminoglycan synthesis during in vitro ageing of human fibroblasts (WI-38). | Synthesis rates of glycosaminoglycans by WI-38 cultures (diploid, human fibroblasts exhibiting a limited number of population doublings in vitro) were determined by incorporation of 35S-sulfate of 14C-glucosamine into cellular and extracellular glycosaminoglycans at different passage levels before phase out. A progress... | Changes of glycosaminoglycan synthesis during in vitro ageing of human fibroblasts (WI-38). Synthesis rates of glycosaminoglycans by WI-38 cultures (diploid, human fibroblasts exhibiting a limited number of population doublings in vitro) were determined by incorporation of 35S-sulfate of 14C-glucosamine into cellular a... | [
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PMID:29505 | Experimental evidence for a unifying concept of the molecular mechanisms of the cellular aging and the cellular neoplastic transformation. | Experimental data supporting a Unifying Concept of the molecular mechanisms of cellular aging and cellular neoplastic transformation of dividing cells in mass culture and clonal culture systems will be described. The Unifying Concept combines the hitherto antithetically presented Differentiation Theory, the Mutation Th... | Experimental evidence for a unifying concept of the molecular mechanisms of the cellular aging and the cellular neoplastic transformation. Experimental data supporting a Unifying Concept of the molecular mechanisms of cellular aging and cellular neoplastic transformation of dividing cells in mass culture and clonal cul... | [
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PMID:29506 | Correlation between DNA repair of embryonic fibroblasts and different life span of 3 inbred mouse strains. | Primary mouse fibroblast cultures were established from 10 day old embryos of 3 inbred strains with a genetically determined different life expectancy. The capacity for unscheduled DNA synthesis following u.v. irradiation was studied in these cells at various passage levels. The mouse fibroblasts show considerable repa... | Correlation between DNA repair of embryonic fibroblasts and different life span of 3 inbred mouse strains. Primary mouse fibroblast cultures were established from 10 day old embryos of 3 inbred strains with a genetically determined different life expectancy. The capacity for unscheduled DNA synthesis following u.v. irr... | [
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PMID:29507 | [Stimulation of enzymes of red blood cells by pyridoxal-5-phosphate in dependence on age (author's transl)]. | In 30 students and 43 patients over 60 years the stimulation of enzymes in erythrocytes by pyridoxal-5-phosphate was tested. GOT in blood and erythrocytes was in the old patients diminished and showed higher values after stimulation. | [Stimulation of enzymes of red blood cells by pyridoxal-5-phosphate in dependence on age (author's transl)]. In 30 students and 43 patients over 60 years the stimulation of enzymes in erythrocytes by pyridoxal-5-phosphate was tested. GOT in blood and erythrocytes was in the old patients diminished and showed higher val... | [
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PMID:29508 | [Age-dependent DNA-content of brain, testis and ovar in men and rats (author's transl)]. | The DNA-content of brain, testis and ovar of Wistar rats (inbred strain) was quantitatively analysed. We observed no significant differences between the several parts of the cerebrum, but between the cerebrum and the cerebellum. Furthermore we demonstrated alterations (with increase and decrease) of the DNA content of ... | [Age-dependent DNA-content of brain, testis and ovar in men and rats (author's transl)]. The DNA-content of brain, testis and ovar of Wistar rats (inbred strain) was quantitatively analysed. We observed no significant differences between the several parts of the cerebrum, but between the cerebrum and the cerebellum. Fu... | [
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PMID:29509 | [Age-dependent enzymatic changes in human cerebral cortex (author's transl)]. | Little information about the possible neurochemical-enzymatic changes occuring during aging of human brain is available. We, therefore, investigated the activity of various enzymes of human brains obtained at autopsy and covering a range from 19 to 91 years. Protein kinase, which mediates the information carried by the... | [Age-dependent enzymatic changes in human cerebral cortex (author's transl)]. Little information about the possible neurochemical-enzymatic changes occuring during aging of human brain is available. We, therefore, investigated the activity of various enzymes of human brains obtained at autopsy and covering a range from... | [
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PMID:29510 | [Adenyl cyclase activity and the stimulation of adenosine 3',5'-cyclic monophosphate in blood vessel walls during ageing and under stress (author's transl)]. | It is well-known that the cAMP-adenylate cyclase system is important in mediating the effects of numerous hormones. We investigated the age-dependent behaviour of this system in aortas and femoral arteries of male Wistar rats (at the age of 10 days, 1, 4, 8, 12, and 22 months). It was found that: The basic adenylate cy... | [Adenyl cyclase activity and the stimulation of adenosine 3',5'-cyclic monophosphate in blood vessel walls during ageing and under stress (author's transl)]. It is well-known that the cAMP-adenylate cyclase system is important in mediating the effects of numerous hormones. We investigated the age-dependent behaviour of... | [
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PMID:29511 | [Histamine H2-receptor blockade and thrombosis prophylaxis with heparin in tetanus. A case report (author's transl)]. | The use of "low-dose" heparin for the purpose of the prophylaxis of thrombosis is not yet general in the treatment of tetanus because this therapy may increase the risk of bleeding gastrointestinal stress-ulcers. The combination of heparin with histamine H2-receptor blockers, however, may be of therapeutic benefit and ... | [Histamine H2-receptor blockade and thrombosis prophylaxis with heparin in tetanus. A case report (author's transl)]. The use of "low-dose" heparin for the purpose of the prophylaxis of thrombosis is not yet general in the treatment of tetanus because this therapy may increase the risk of bleeding gastrointestinal stre... | [
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PMID:29524 | [Neurostimulation--endorphins. Personal opinion in the guise of an introduction]. | Up until 1974 & 1975, Anesthesiologie observed with a certain reserve progress, which was nevertheless spectacular, in the physiological aspects of pain. The fundamental theory of the inhibition of small algophoric fibres by large fibres (NOOR-DENBOS, 1959), the striking theory of spinal control (WALL and MELZACK, ... | [Neurostimulation--endorphins. Personal opinion in the guise of an introduction]. Up until 1974 & 1975, Anesthesiologie observed with a certain reserve progress, which was nevertheless spectacular, in the physiological aspects of pain. The fundamental theory of the inhibition of small algophoric fibres by large fib... | [
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PMID:29525 | [Current data on pain pathways]. | 1--The classical notion attributing the conduction of painful messages to only the A delta and C fibres will be discussed. 2--Spinal cord cells of layers I, V and VIII received painful messages and their physiological properties will be compared. 3--The origin within the cell layers of the spinal cord of the various as... | [Current data on pain pathways]. 1--The classical notion attributing the conduction of painful messages to only the A delta and C fibres will be discussed. 2--Spinal cord cells of layers I, V and VIII received painful messages and their physiological properties will be compared. 3--The origin within the cell layers of ... | [
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PMID:29528 | [Pharmacology of morphine and its derivatives (review)]. | Morphine, the principal alkaloid of "papaver somniferum" is the reference substance of central analgesics, the parmacodynamic constants of which are: analgesia and the possibility of addiction. Respiratory depression is, for many of them, a grave side-effect. At the present time, no substance in this category is fully ... | [Pharmacology of morphine and its derivatives (review)]. Morphine, the principal alkaloid of "papaver somniferum" is the reference substance of central analgesics, the parmacodynamic constants of which are: analgesia and the possibility of addiction. Respiratory depression is, for many of them, a grave side-effect. At ... | [
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PMID:29530 | [Morphine analgesia: neurobiologic data]. | Recent Neurobiological (Neurophysiological, Histochemical, Neurochemical and behavioural studies) data have indicated that the analgesic effects of morphine may, at least in part, be explained by two modes of action. A--Morphine has a direct depressive action at a spinal level on the activity of neurones of the grey ma... | [Morphine analgesia: neurobiologic data]. Recent Neurobiological (Neurophysiological, Histochemical, Neurochemical and behavioural studies) data have indicated that the analgesic effects of morphine may, at least in part, be explained by two modes of action. A--Morphine has a direct depressive action at a spinal level ... | [
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PMID:29533 | [Opiate receptors and endorphins at the central nervous system level]. | Four years ago, sterospecific sites for the bending of opiates were discovered within the brain of animals and the human being. All of the properties of these sites are in conformity with the proposition that they are pharmacological receptors which have long been postulated for these drugs. The binding of morphine or ... | [Opiate receptors and endorphins at the central nervous system level]. Four years ago, sterospecific sites for the bending of opiates were discovered within the brain of animals and the human being. All of the properties of these sites are in conformity with the proposition that they are pharmacological receptors which... | [
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PMID:29535 | [Electrophysiological effects of opiates and endogenous peptides on central neurons]. | The influence of micro-iontophoretically administered opiates and opiate peptides on the activity of single neurones in the central nervous system will be discussed. It will be shown that in single neurone studies in several different supraspinal regions opiates and opiate peptides have similar actions on individual ne... | [Electrophysiological effects of opiates and endogenous peptides on central neurons]. The influence of micro-iontophoretically administered opiates and opiate peptides on the activity of single neurones in the central nervous system will be discussed. It will be shown that in single neurone studies in several different... | [
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PMID:29537 | [Transcutaneous electrotherapy in the treatment of chronic post-zoster pain]. | Transcutaneous electrotherapy has been employed in 112 patients with chronic pains of various origins. The immediate and long term results are not considered, at whole, satisfactory, especially for length and quality of the obtained improvement. Only patients with chronic post-zoosterian neuralgia had good results, or ... | [Transcutaneous electrotherapy in the treatment of chronic post-zoster pain]. Transcutaneous electrotherapy has been employed in 112 patients with chronic pains of various origins. The immediate and long term results are not considered, at whole, satisfactory, especially for length and quality of the obtained improveme... | [
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PMID:29538 | [Effects of percutaneous heterosegmental electric stimulation (electro-acupuncture) on the nociceptive flexion reflex in man]. | A comparative study of the effects of electro-acupuncture of the HO KU point and of a placebo control point were carried out in man, taking as an objective test of pain the threshold of a pain induced flexion reflex. In the absence of electrical stimulation of the HO KU point, or of the control point, no variation in t... | [Effects of percutaneous heterosegmental electric stimulation (electro-acupuncture) on the nociceptive flexion reflex in man]. A comparative study of the effects of electro-acupuncture of the HO KU point and of a placebo control point were carried out in man, taking as an objective test of pain the threshold of a pain ... | [
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PMID:29539 | [Modulation of experimental dental pain in man with acupuncture and by transcutaneous electric stimulation]. | We have studied the effects of electrical acupuncture stimulation and transcutaneous electrical stimulation on the ability of human volunteers to perceive pain. Both psychophysical indices and measures of cerebral evoked responses to painful stimuli have been used to demonstrate that these treatments reduce pain percep... | [Modulation of experimental dental pain in man with acupuncture and by transcutaneous electric stimulation]. We have studied the effects of electrical acupuncture stimulation and transcutaneous electrical stimulation on the ability of human volunteers to perceive pain. Both psychophysical indices and measures of cerebr... | [
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PMID:29540 | [Modes of action of various aspects of analgesia by stimulation]. | A study of 12 patients suffering from chronic lumbar pain led to a comparison of the results of treatment with traditional acupuncture and that with transcutaneous electrical stimulation. The degree and quality of pain, as well as the duration of relief after treatment, were analyzed in an attempt to differentiate betw... | [Modes of action of various aspects of analgesia by stimulation]. A study of 12 patients suffering from chronic lumbar pain led to a comparison of the results of treatment with traditional acupuncture and that with transcutaneous electrical stimulation. The degree and quality of pain, as well as the duration of relief ... | [
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PMID:29542 | [Chronic intracerebral electric stimulation for analgesia in man]. | This report concerns the current status of the results of intraencephalic implantations carried out up to the present time in man with the aim of relieving certain forms of chronic pain. It places little emphasis upon the neuro-physiological basis of these implantations, which have been studied at length during previou... | [Chronic intracerebral electric stimulation for analgesia in man]. This report concerns the current status of the results of intraencephalic implantations carried out up to the present time in man with the aim of relieving certain forms of chronic pain. It places little emphasis upon the neuro-physiological basis of th... | [
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PMID:29550 | Differential responsiveness of central noradrenergic and dopaminergic neuron tyrosine hydroxylase to hypophysectomy, ACTH and glucocorticoid administration. | Hypophysectomy leads to a small increase in tyrosine hydroxylase activity of all brain areas containing noradrenergic neurons or tuberoinfundibular dopamine neurons, but nigroneostriatal dopamine neurons are not so affected. ACTH or corticosterone treatment inhibited this effect of hypophysectomy in some noradrenergic ... | Differential responsiveness of central noradrenergic and dopaminergic neuron tyrosine hydroxylase to hypophysectomy, ACTH and glucocorticoid administration. Hypophysectomy leads to a small increase in tyrosine hydroxylase activity of all brain areas containing noradrenergic neurons or tuberoinfundibular dopamine neuron... | [
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PMID:29546 | [Polyol dehydrogenases in mycobacteria (author's transl)]. | Contrary to the the tubercle bacilli (H37Ra, BCG), Mycobacterium phlei, grown on Sauton medium, formed the NAD+ dependent dehydrogenases that catalyse the oxidation of ribitol, sorbitol and mannitol. These enzymes were separated by chromatography on DEAE-cellulose and Sephadex G-200. In the present work we have princip... | [Polyol dehydrogenases in mycobacteria (author's transl)]. Contrary to the the tubercle bacilli (H37Ra, BCG), Mycobacterium phlei, grown on Sauton medium, formed the NAD+ dependent dehydrogenases that catalyse the oxidation of ribitol, sorbitol and mannitol. These enzymes were separated by chromatography on DEAE-cellul... | [
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PMID:29554 | Ocular hypotensive efficacy of topical epinephrine in normotensive and hypertensive rabbits: continuous drug delivery vs eyedrops. | The ocular hypotensive efficacy of continuously delivered epinephrine is compared to that of pulsed doses provided by eyedrops in both normotensive and hypertensive rabbit eyes. In normotensive eyes, 2 microgram/hr and 4 microgram/hr epinephrine delivered into the tear film continuously for 12 hours reduces intraocular... | Ocular hypotensive efficacy of topical epinephrine in normotensive and hypertensive rabbits: continuous drug delivery vs eyedrops. The ocular hypotensive efficacy of continuously delivered epinephrine is compared to that of pulsed doses provided by eyedrops in both normotensive and hypertensive rabbit eyes. In normoten... | [
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PMID:29555 | Improved methods for detecting enteric viruses in oysters. | New and improved methods for concentrating enteroviruses, reoviruses, and adenoviruses from oysters have been developed and evaluated. Viruses are efficiently adsorbed to homogenized oyster meat by adjusting the homogenate to pH 5.0 and a conductivity of less than or equal to 2,000 mg of NaCl per liter. After low-speed... | Improved methods for detecting enteric viruses in oysters. New and improved methods for concentrating enteroviruses, reoviruses, and adenoviruses from oysters have been developed and evaluated. Viruses are efficiently adsorbed to homogenized oyster meat by adjusting the homogenate to pH 5.0 and a conductivity of less t... | [
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PMID:29556 | Comparative effects of ammonia and related compounds on poliovirus. | The abilities of ammonia and related compounds to inactivate poliovirus were compared. Compounds virucidal at pH 9.5 had the following order of activities: ethylamine greater than propylamine, dimethylamine, methylamine greater than ammonia greater than 2-methoxyethylamine. | Comparative effects of ammonia and related compounds on poliovirus. The abilities of ammonia and related compounds to inactivate poliovirus were compared. Compounds virucidal at pH 9.5 had the following order of activities: ethylamine greater than propylamine, dimethylamine, methylamine greater than ammonia greater tha... | [
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PMID:29557 | Characteristics of bacteriophages for Micromonospora purpurea. | Chemical and physical stabilities of bacteriophages øUW 21 and øUW 51 infecting Micromonospora purpurea ATCC 15835 were examined. Both phages were stable over the pH range of 5 to 8 and to heating at temperatures up to 50 degrees C and especially stable in buffer containing magnesium ion. Exposure to 1 M Ca(NO3)2 inact... | Characteristics of bacteriophages for Micromonospora purpurea. Chemical and physical stabilities of bacteriophages øUW 21 and øUW 51 infecting Micromonospora purpurea ATCC 15835 were examined. Both phages were stable over the pH range of 5 to 8 and to heating at temperatures up to 50 degrees C and especially stable in ... | [
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PMID:29558 | Inactivation of enteroviruses by ascorbic acid and sodium bisulfite. | Poliovirus type 1, coxsackievirus type A9, and echovirus type 7 were inactivated by sodium bisulfite and ascorbic acid. Inactivation rates depended upon concentration, temperature, and pH. RNA infectivity was lost during inactivation; the capsid was also altered by these inactivating agents, as determined by enzyme sen... | Inactivation of enteroviruses by ascorbic acid and sodium bisulfite. Poliovirus type 1, coxsackievirus type A9, and echovirus type 7 were inactivated by sodium bisulfite and ascorbic acid. Inactivation rates depended upon concentration, temperature, and pH. RNA infectivity was lost during inactivation; the capsid was a... | [
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PMID:29559 | Development of quantitative methods for the detection of enteroviruses in sewage sludges during activation and following land disposal. | The development and evaluation of methods for the quantitative recovery of enteroviruses from sewage sludge are reported. Activated sewage sludge solids were collected by centrifugation, and elution of the solid-associated virus was accomplished by mechanical agitation in glycine buffer at pH 11.0. Eluted viruses were ... | Development of quantitative methods for the detection of enteroviruses in sewage sludges during activation and following land disposal. The development and evaluation of methods for the quantitative recovery of enteroviruses from sewage sludge are reported. Activated sewage sludge solids were collected by centrifugatio... | [
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PMID:29560 | Hydrogen peroxide and superoxide radical formation in anaerobic broth media exposed to atmospheric oxygen. | Fourteen different broth media were autoclaved under anaerobic conditions and then exposed to atmospheric oxygen. The hydrogen peroxide and superoxide radical formation as well as the bactericidal effect of the media were studied. The rate of killing of Peptostreptococcus anaerobius VPI 4330-1 was high in media that ra... | Hydrogen peroxide and superoxide radical formation in anaerobic broth media exposed to atmospheric oxygen. Fourteen different broth media were autoclaved under anaerobic conditions and then exposed to atmospheric oxygen. The hydrogen peroxide and superoxide radical formation as well as the bactericidal effect of the me... | [
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PMID:29561 | Presence and partial characterization of internal acid protease of Aspergillus oryzae. | The presence and partial characterization of the internal acid protease (EC 2.4.23.6) of Aspergillus oryzae has been investigated. Although the majority of the acid protease is external and present in the culture filtrate, a significant amount of the active enzyme is firmly bound to the cells; it is not released by rep... | Presence and partial characterization of internal acid protease of Aspergillus oryzae. The presence and partial characterization of the internal acid protease (EC 2.4.23.6) of Aspergillus oryzae has been investigated. Although the majority of the acid protease is external and present in the culture filtrate, a signific... | [
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PMID:29562 | Prevalence of fungi during Skylab missions. | Samples for mycological analysis were collected from surfaces in the Skylab spacecraft before launch and during flight for each manned mission. Fungal contamination levels were low during the first two flights; however, the species recovered were different for each mission. On the third mission, widespread contaminatio... | Prevalence of fungi during Skylab missions. Samples for mycological analysis were collected from surfaces in the Skylab spacecraft before launch and during flight for each manned mission. Fungal contamination levels were low during the first two flights; however, the species recovered were different for each mission. O... | [
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PMID:29563 | Phthalate and 4-hydroxyphthalate metabolism in Pseudomonas testosteroni: purification and properties of 4,5-dihydroxyphthalate decarboxylase. | Phthalate is degraded through 4,5-dihydroxyphthalate and protocatechuate in Pseudomonas testosteroni NH1000. The ezyme 4,5-dihydroxyphthalate decarboxylase, catalyzing the conversion of 4,5-dihydroxyphthalate to protocatechuate and carbon dioxide, was purified approximately 130-fold from phthalate-induced cells of a pr... | Phthalate and 4-hydroxyphthalate metabolism in Pseudomonas testosteroni: purification and properties of 4,5-dihydroxyphthalate decarboxylase. Phthalate is degraded through 4,5-dihydroxyphthalate and protocatechuate in Pseudomonas testosteroni NH1000. The ezyme 4,5-dihydroxyphthalate decarboxylase, catalyzing the conver... | [
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PMID:29564 | Tissue sterility in uneviscerated carcasses. | Sheep muscle tissue removed aseptically from control carcasses, from uneviscerated carcasses held at 20 degrees C for 24 h, and from carcasses of sheep subjected to stress before slaughter was examined for the presence of bacteria. All samples from a total of 68 carcasses were sterile. Whole-body autoradiography of mou... | Tissue sterility in uneviscerated carcasses. Sheep muscle tissue removed aseptically from control carcasses, from uneviscerated carcasses held at 20 degrees C for 24 h, and from carcasses of sheep subjected to stress before slaughter was examined for the presence of bacteria. All samples from a total of 68 carcasses we... | [
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PMID:29565 | Storage quality of dark, firm, dry meat. | Dark, firm, dry meat contains little or no glucose. Therefore, spoilage bacteria growing on such meat immediately attack amino acids so that spoilage odors and ammonia are detectable at comparatively low cell densities (about 10(6)/cm2). | Storage quality of dark, firm, dry meat. Dark, firm, dry meat contains little or no glucose. Therefore, spoilage bacteria growing on such meat immediately attack amino acids so that spoilage odors and ammonia are detectable at comparatively low cell densities (about 10(6)/cm2). | [
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PMID:29566 | Establishment of a heat inactivation curve for Clostridium botulinum 62A toxin in beef broth. | A procedure is described for establishing a heat inactivation curve for the toxin of Clostridium botulinum 62A in beef broth. The effect of toxin titer, pH, and the type of acid employed for pH adjustment on the heat stability of the toxin is described. | Establishment of a heat inactivation curve for Clostridium botulinum 62A toxin in beef broth. A procedure is described for establishing a heat inactivation curve for the toxin of Clostridium botulinum 62A in beef broth. The effect of toxin titer, pH, and the type of acid employed for pH adjustment on the heat stability... | [
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PMID:29580 | Membrane bound pyrophosphatases in Entamoeba histolytica. | Entamoeba histolytica homogenates are capable of hydrolyzing a range of inorganic and organic pyrophosphates. Two separate activities are present: an inorganic pyrophosphatase hydrolyzing inorganic pyrophosphate and linear tripolyphosphate, and a nucleoside diphosphatase hydrolyzing thiamine pyrophosphate and nucleosid... | Membrane bound pyrophosphatases in Entamoeba histolytica. Entamoeba histolytica homogenates are capable of hydrolyzing a range of inorganic and organic pyrophosphates. Two separate activities are present: an inorganic pyrophosphatase hydrolyzing inorganic pyrophosphate and linear tripolyphosphate, and a nucleoside diph... | [
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PMID:29585 | Fine structural localization of alkaloid synthesis in endoplasmic reticulum of submerged Claviceps purpurea. | Acetyl coenzyme A (CoA) carboxylase (EC 6.4.1.2), an enzyme catalyzing the synthesis of malonyl-CoA, was cytochemically localized in endoplasmic reticulum (ER) of sclerotia-like cells of submerged Claviceps purpurea Tul. producing clavine alkaloids. The enzymic activity was structurally bound in unit membranes of ER st... | Fine structural localization of alkaloid synthesis in endoplasmic reticulum of submerged Claviceps purpurea. Acetyl coenzyme A (CoA) carboxylase (EC 6.4.1.2), an enzyme catalyzing the synthesis of malonyl-CoA, was cytochemically localized in endoplasmic reticulum (ER) of sclerotia-like cells of submerged Claviceps purp... | [
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PMID:29586 | Evidence for an incomplete reductive carboxylic acid cycle in Methanobacterium thermoautotrophicum. | The involvement of reactions of the tricarboxylic acid cycle in autotrophic CO2 fixation in Methanobacterium thermoautotrophicum was investigated. The incorporation of succinate into glutamate (= alpha-ketoglutarate), aspartate (= oxaloacetate) and alanine (= pyruvate) was studied. The organism was grown on H2 plus CO2... | Evidence for an incomplete reductive carboxylic acid cycle in Methanobacterium thermoautotrophicum. The involvement of reactions of the tricarboxylic acid cycle in autotrophic CO2 fixation in Methanobacterium thermoautotrophicum was investigated. The incorporation of succinate into glutamate (= alpha-ketoglutarate), as... | [
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PMID:29588 | Cellulose degradation and cellulase formation by Phialophora malorum. | The formation of cellulases and beta-glucosidase and their location in the fungus Phialophora malorum was studied on some different carbon sources. The cellulases were found to be partly cell-free and partly cell-bound during growth on cellulose and carboxymethyl-cellulose. Glucose and cellobiose repressed the cellulas... | Cellulose degradation and cellulase formation by Phialophora malorum. The formation of cellulases and beta-glucosidase and their location in the fungus Phialophora malorum was studied on some different carbon sources. The cellulases were found to be partly cell-free and partly cell-bound during growth on cellulose and ... | [
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PMID:29589 | Incorporation of labeled small molecules into rubratoxin. | A sterile glucose-mineral salts broth was inoculated with conidia of Penicillium rubrum P-13 and P-3290. Radiolabeled compounds were added to some cultures, these being incubated quiescently at 28 degrees C for 14 days. Other stationary cultures were grown for 21 days, received labeled compounds, and were then grown fo... | Incorporation of labeled small molecules into rubratoxin. A sterile glucose-mineral salts broth was inoculated with conidia of Penicillium rubrum P-13 and P-3290. Radiolabeled compounds were added to some cultures, these being incubated quiescently at 28 degrees C for 14 days. Other stationary cultures were grown for 2... | [
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