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PMID:29804 | Plasma estradiol as a predictor of preterm labor. | Studies have shown a rapid rise of plasma estradiol-17beta in the maternal circulation before the occurrence of preterm labor. We have attempted to perform a linear regression analysis of the data from normal pregnancies and to set up a 95% upper prediction limit for the normal range of the estradiol level for each wee... | Plasma estradiol as a predictor of preterm labor. Studies have shown a rapid rise of plasma estradiol-17beta in the maternal circulation before the occurrence of preterm labor. We have attempted to perform a linear regression analysis of the data from normal pregnancies and to set up a 95% upper prediction limit for th... | [
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PMID:29806 | The role of methylergonovine maleate in augmenting extraamniotic saline for midtrimester abortion. | This study was conducted in Bombay, India, to evaluate the role of oral methylergonovine maleate (Methergine, Sandoz Pharmaceuticals, East Hanover, N.J., USA) in augmenting the effect of intermittent extraamniotic instillation of 20% saline for midtrimester abortion in 200 patients. Methylergonovine maleate (MEM) admin... | The role of methylergonovine maleate in augmenting extraamniotic saline for midtrimester abortion. This study was conducted in Bombay, India, to evaluate the role of oral methylergonovine maleate (Methergine, Sandoz Pharmaceuticals, East Hanover, N.J., USA) in augmenting the effect of intermittent extraamniotic instill... | [
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PMID:29807 | Atypical cervical cytology and colposcopic directed biopsy. | A cervical cytologic diagnosis of inflammatory stypia was made in 319 patients during a 42-month period. Two hundred twenty-five of those patients underwent colposcopy, and biopsy was performed in 155 patients. Mild to severe dysplasia was diagnosed in 115 patients, for a 36% prevalence of cervical intraepithelial neop... | Atypical cervical cytology and colposcopic directed biopsy. A cervical cytologic diagnosis of inflammatory stypia was made in 319 patients during a 42-month period. Two hundred twenty-five of those patients underwent colposcopy, and biopsy was performed in 155 patients. Mild to severe dysplasia was diagnosed in 115 pat... | [
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PMID:29808 | The pure gonadal dysgenesis syndrome. | Two cases of gonadal dysgenesis in phenotypic females associated with different chromosomal patterns are discussed. Both patients presented with primary amenorrhea and were characterized by tall stature and underdeveloped secondary sex characteristics and external and internal reproductive organs. The karyotype of the ... | The pure gonadal dysgenesis syndrome. Two cases of gonadal dysgenesis in phenotypic females associated with different chromosomal patterns are discussed. Both patients presented with primary amenorrhea and were characterized by tall stature and underdeveloped secondary sex characteristics and external and internal repr... | [
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PMID:29809 | Oral contraceptive pills and clinical otosclerosis. | Clinical otosclerosis is a familial disease which is more frequent among women in their reproductive years. The condition usuallly is aggravated by pregnancy. Endocrinologic variables may influence the time of onset and the course of the disease. It is suspected that oral contraceptives (OCs) might stimulate the onset ... | Oral contraceptive pills and clinical otosclerosis. Clinical otosclerosis is a familial disease which is more frequent among women in their reproductive years. The condition usuallly is aggravated by pregnancy. Endocrinologic variables may influence the time of onset and the course of the disease. It is suspected that ... | [
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PMID:29810 | Diagnostic laparoscopy. | Six hundred fifty-eight laparoscopies were performed at St. Luke's Hospital, Kansas City, Missouri, USA, between March 1, 1976 and February 28, 1977. One hundred sixty-eight (25.5%) were performed for diagnostic purposes. A review of the preoperative diagnoses and the laparoscopic findings demonstrates the value of lap... | Diagnostic laparoscopy. Six hundred fifty-eight laparoscopies were performed at St. Luke's Hospital, Kansas City, Missouri, USA, between March 1, 1976 and February 28, 1977. One hundred sixty-eight (25.5%) were performed for diagnostic purposes. A review of the preoperative diagnoses and the laparoscopic findings demon... | [
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PMID:29811 | Endometriosis presenting as acute appendicitis. | A rare case of endometriosis presenting as acute appendicitis is reported. Appendectomy was performed with excellent results. | Endometriosis presenting as acute appendicitis. A rare case of endometriosis presenting as acute appendicitis is reported. Appendectomy was performed with excellent results. | [
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PMID:29812 | Urinary electrolyte profiles after amiloride, hydrochlorthiazide and the combination. | Acute effects of amiloride (5 mg) (A), hydrochlorthiazide (50 mg) (H) and the combination (50 + 5 mg) (HA) on urinary electrolyte excretion and pH of ten healthy volunteers--taking placebo five times and twice randomly A and HA and once H--were studied during one day. Amiloride showed a natriuretic effect, which in com... | Urinary electrolyte profiles after amiloride, hydrochlorthiazide and the combination. Acute effects of amiloride (5 mg) (A), hydrochlorthiazide (50 mg) (H) and the combination (50 + 5 mg) (HA) on urinary electrolyte excretion and pH of ten healthy volunteers--taking placebo five times and twice randomly A and HA and on... | [
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PMID:29815 | Long-term effect of pH on B-cell function in isolated islets of Langerhans in tissue culture. | Collagenase isolated mouse pancreatic islets were maintained in tissue culture for up to 5 months in a culture medium buffered with Hepes and the pH varying between 6.8 and 7.6. The amount of insulin released into the medium and the insulin response to glucose and glucose plus theophylline were measured during the cult... | Long-term effect of pH on B-cell function in isolated islets of Langerhans in tissue culture. Collagenase isolated mouse pancreatic islets were maintained in tissue culture for up to 5 months in a culture medium buffered with Hepes and the pH varying between 6.8 and 7.6. The amount of insulin released into the medium a... | [
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PMID:29817 | Cyclic nucleotide-dependent phosphorylation of rat intestinal microvillus and basal-lateral membrane proteins by an endogenous protein kinase. | Both the microvillus and basal-lateral membrane components of intestinal epithelial cells were found to contain endogenous cyclic nucleotide-dependent protein kinases and their endogenous protein substrates. The phosphorylation of either membrane component using [gamma-32P]ATP as substrate, occurred very rapidly, reach... | Cyclic nucleotide-dependent phosphorylation of rat intestinal microvillus and basal-lateral membrane proteins by an endogenous protein kinase. Both the microvillus and basal-lateral membrane components of intestinal epithelial cells were found to contain endogenous cyclic nucleotide-dependent protein kinases and their ... | [
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PMID:29820 | [Initial experience with a tocolysis ward (author's transl)]. | Premature labour is best treated in a special ward, the tocolysis ward. From 1972 to 1975 there were around 8% premature deliveries. During the first six months of 1976 there were still around 8% premature deliveries. During the second six months of 1976 the premature rate was lowered to 6% in the tocolysis ward. This ... | [Initial experience with a tocolysis ward (author's transl)]. Premature labour is best treated in a special ward, the tocolysis ward. From 1972 to 1975 there were around 8% premature deliveries. During the first six months of 1976 there were still around 8% premature deliveries. During the second six months of 1976 the... | [
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PMID:29824 | Genetic studies of acridine-induced mutants in Streptococcus pneumoniae. | The mutagenic properties of acridines on pneumococcus are described. All seven acridines tested were mutagenic at the amiA locus conferring a resistance to 10(-5) M aminopterin. The effects of quinacrine were more specifically investigated. It was observed that: mutants can be obtained only by treatment of exponentiall... | Genetic studies of acridine-induced mutants in Streptococcus pneumoniae. The mutagenic properties of acridines on pneumococcus are described. All seven acridines tested were mutagenic at the amiA locus conferring a resistance to 10(-5) M aminopterin. The effects of quinacrine were more specifically investigated. It was... | [
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PMID:29826 | [Effects of psychotropic drugs on the spinal ventral root reflexes in cats. A comparison of the depressant actions in intact and spinal preparations (author's transl)]. | Effects of the typical psychotropic drugs such as neuroleptics, tricyclic antidepressants and benzodiazepines on the monosynaptic reflex (MSR) and polysynaptic reflex (PSR) were investigated using intact and spinal cats. Drugs used were chlorpromazine, levomepromazine, perphenazine, prochlorperazine, droperidol, halope... | [Effects of psychotropic drugs on the spinal ventral root reflexes in cats. A comparison of the depressant actions in intact and spinal preparations (author's transl)]. Effects of the typical psychotropic drugs such as neuroleptics, tricyclic antidepressants and benzodiazepines on the monosynaptic reflex (MSR) and poly... | [
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PMID:29827 | [Behavioral and EEG effects of triazolam in comparison with those of diazepam (author's transl)]. | Triazolam was 4 to 5 times as potent as diazepam in reducing hyperemotionality of either septal-lesioned or olfactory bulbectomized rats (O.B. rats), and in suppressing muricide in O.B. rats. This agent was equipotent with diazepam in inhibiting fighting behavior of long-term isolated mice, but was longer in duration o... | [Behavioral and EEG effects of triazolam in comparison with those of diazepam (author's transl)]. Triazolam was 4 to 5 times as potent as diazepam in reducing hyperemotionality of either septal-lesioned or olfactory bulbectomized rats (O.B. rats), and in suppressing muricide in O.B. rats. This agent was equipotent with... | [
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PMID:29828 | [Effects of triazolam on conditioned behavior in rats (author's transl)]. | Effects of triazolam on various types of conditioned behavior were investigated and compared mainly with diaepam in rats. The active conditioned avoidance response of the rat in a Shuttle box was inhibited by triazolam and diazepam only at large doses. The passive avoidance response in a step-down method was not affect... | [Effects of triazolam on conditioned behavior in rats (author's transl)]. Effects of triazolam on various types of conditioned behavior were investigated and compared mainly with diaepam in rats. The active conditioned avoidance response of the rat in a Shuttle box was inhibited by triazolam and diazepam only at large ... | [
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PMID:29829 | D-Amino acids of the amino acid pool and occurrence of racemase and D-amino acid oxidase activities in Escherichia coli B. | Less than 20% of the amino acid content of the amino acid pool of Escherichia coli B exists in the D-form. Alanine, glutamic acid, and valine were shown by gas- chromatography to be partially in the D-form. Only D-alanine was formed by racemization in the crude extract of this organism. Alanine racemase was easily rele... | D-Amino acids of the amino acid pool and occurrence of racemase and D-amino acid oxidase activities in Escherichia coli B. Less than 20% of the amino acid content of the amino acid pool of Escherichia coli B exists in the D-form. Alanine, glutamic acid, and valine were shown by gas- chromatography to be partially in th... | [
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PMID:29830 | [Absorption in the human small intestine relative to the intraluminal milieu]. | The bulk of water and electrolyte absorption takes place in the human jejunum from isotonic solutions, and is determined largely by special transport mechanisms for different monosaccharides, amino acids and dipeptides. This is of considerable significance for regaining the large volumes of fluid delivered to the small... | [Absorption in the human small intestine relative to the intraluminal milieu]. The bulk of water and electrolyte absorption takes place in the human jejunum from isotonic solutions, and is determined largely by special transport mechanisms for different monosaccharides, amino acids and dipeptides. This is of considerab... | [
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PMID:29831 | [Psychotropic drugs as tools for clinical research into schizophrenia (author's transl)]. | There is considerable similarity between paranoid schizophrenia and psychoses provoked by dopaminergic overstimulation in the central nervous system. The fact that neuroleptics are able to block dopaminergic neural activity has led to the hypothesis that there might exist a common biochemical substrate for schizophreni... | [Psychotropic drugs as tools for clinical research into schizophrenia (author's transl)]. There is considerable similarity between paranoid schizophrenia and psychoses provoked by dopaminergic overstimulation in the central nervous system. The fact that neuroleptics are able to block dopaminergic neural activity has le... | [
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PMID:29832 | [Indicated and non-indicated administration of antibiotics in surgery (author's transl)]. | Considerations and own experience regarding prophylactic administration of antibiotics and therapeutic customs in surgery are discussed. Based on own and long-term studies recommendations are given for effective and purposeful use of chemotherapy in surgery. | [Indicated and non-indicated administration of antibiotics in surgery (author's transl)]. Considerations and own experience regarding prophylactic administration of antibiotics and therapeutic customs in surgery are discussed. Based on own and long-term studies recommendations are given for effective and purposeful use... | [
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PMID:29839 | Epstein-Barr virus infection following bone-marrow transplantation. | A 12-year-old patient with acute lymphoblastic leukemia received a bone-marrow transplant (BMT) from a matched sibling donor. Nine weeks prior to transplant the donor experienced Epstein-Barr virus (EBV)-induced infectious mononucleosis. The bone-marrow recipient was EBV-negative at the time of transplant; however, 4 w... | Epstein-Barr virus infection following bone-marrow transplantation. A 12-year-old patient with acute lymphoblastic leukemia received a bone-marrow transplant (BMT) from a matched sibling donor. Nine weeks prior to transplant the donor experienced Epstein-Barr virus (EBV)-induced infectious mononucleosis. The bone-marro... | [
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PMID:29840 | Rate constants of absorption versus physico-chemical parameters. | We examined the velocity constants of buccal absorption in the case of 10 drugs. The measurements tending towards what is the coherence between the velocity constants and the physico-chemical parameters of the drugs. On the basis of our investigations one can see that the dipol moment offers more reliable information f... | Rate constants of absorption versus physico-chemical parameters. We examined the velocity constants of buccal absorption in the case of 10 drugs. The measurements tending towards what is the coherence between the velocity constants and the physico-chemical parameters of the drugs. On the basis of our investigations one... | [
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PMID:29842 | Photolytic inhibition and labeling of proteins with aryl diazonium compounds. | In the course of preparing aryl azide derivatives for use as photoprobes, we have observed significant light sensitivity in the precursor aryl diazonium compounds. The photosensitive properties of this class of compounds are of interest since they will seek out cationic binding sites in biological targets, and can be e... | Photolytic inhibition and labeling of proteins with aryl diazonium compounds. In the course of preparing aryl azide derivatives for use as photoprobes, we have observed significant light sensitivity in the precursor aryl diazonium compounds. The photosensitive properties of this class of compounds are of interest since... | [
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PMID:29843 | The denaturation of covalently inhibited swine pepsin. | Studies are reported on the denaturation of freshly prepared, intact swine pepsin, which was inactivated by reaction with diazoacetylglycine ethyl ester, to prevent autolysis. Denaturation about pH 6 was found to involve a small expansion of the molecular domain with some loss of organized secondary structure. On the o... | The denaturation of covalently inhibited swine pepsin. Studies are reported on the denaturation of freshly prepared, intact swine pepsin, which was inactivated by reaction with diazoacetylglycine ethyl ester, to prevent autolysis. Denaturation about pH 6 was found to involve a small expansion of the molecular domain wi... | [
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PMID:29857 | Cornea endothelial bicarbonate fluxes following preservation in solutions of varying composition. | Numerous modifications have been made in MK solution, primarily concerned with alterations in both bicarbonate concentration and PCO2. Variations of the solutions from high bicarbonate to low bicarbonate and either high or low PCO2 were made which resulted in a decreased net bicarbonate flux across the endothelium afte... | Cornea endothelial bicarbonate fluxes following preservation in solutions of varying composition. Numerous modifications have been made in MK solution, primarily concerned with alterations in both bicarbonate concentration and PCO2. Variations of the solutions from high bicarbonate to low bicarbonate and either high or... | [
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PMID:29860 | Thymic humoral factor in the assessment of T lymphocytics in a patient with T cell chronic lymphocyte leukemia. | Peripheral blood lymphocytes from a patient with T cell chronic lymphocytic leukemia were examined by a combination of cell markers (E and M rosettes, and surface Ig), the graft-vs.-host reaction, thymic humoral factor (THF) and scanning electron microscopy. It was not possible, at first, to determine by conventional m... | Thymic humoral factor in the assessment of T lymphocytics in a patient with T cell chronic lymphocyte leukemia. Peripheral blood lymphocytes from a patient with T cell chronic lymphocytic leukemia were examined by a combination of cell markers (E and M rosettes, and surface Ig), the graft-vs.-host reaction, thymic humo... | [
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PMID:29863 | Detection of lipopolysaccharide in suspected bacteriuric urine using a carbocyanine dye. | Currently practiced methods for the detection of gram negative bacteriuria require culturing and overnight incubation. Such an approach to bacteriuria detection is unacceptable for any screening program which requires rapid presumptive evidence of infection. In this study, the lipopolysaccharide-dependent formation of ... | Detection of lipopolysaccharide in suspected bacteriuric urine using a carbocyanine dye. Currently practiced methods for the detection of gram negative bacteriuria require culturing and overnight incubation. Such an approach to bacteriuria detection is unacceptable for any screening program which requires rapid presump... | [
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PMID:29864 | [Conservative drug therapy of neurogenic bladder disorders]. | Today neuropharmacas are a helpful part in the conservative treatment of the neurogenic bladder disorders. They are, or course, no "wonder-drugs" and usually lead to an improvement only of the troubles, but rarely to complete cure. If monotherapy does not lead to the results wanted, one should combine drugs of the same... | [Conservative drug therapy of neurogenic bladder disorders]. Today neuropharmacas are a helpful part in the conservative treatment of the neurogenic bladder disorders. They are, or course, no "wonder-drugs" and usually lead to an improvement only of the troubles, but rarely to complete cure. If monotherapy does not lea... | [
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PMID:29865 | [Quantitative determination of phosphates in urinary calculi and their matrices]. | The question whether the phosphate participates actively in the calculogenesis or whether it is only an accidental enclosure in the stone material can, in our opinion, only be answered by the quantitative determination of phosphorus in the stone material resp. in the organic stone matrix. The high enrichment of phospho... | [Quantitative determination of phosphates in urinary calculi and their matrices]. The question whether the phosphate participates actively in the calculogenesis or whether it is only an accidental enclosure in the stone material can, in our opinion, only be answered by the quantitative determination of phosphorus in th... | [
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PMID:29866 | [Current considerations on male secretory sterility]. | The problems of male sterility are considered in the light of fundamentals underlying the embryology and histophysiology of spermatogenesis and its hormonal control. Some forms of infertility are now understood but no treatment for them has yet been found. The mechanisms of other forms still elude firm definition: this... | [Current considerations on male secretory sterility]. The problems of male sterility are considered in the light of fundamentals underlying the embryology and histophysiology of spermatogenesis and its hormonal control. Some forms of infertility are now understood but no treatment for them has yet been found. The mecha... | [
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PMID:29867 | Determinants of oxygen uptake during sodium bicarbonate infusion. | Steady-state passive hyperventilation alkalosis produces a predictable increase in oxygen uptake (VO2) proportional to the change in arterial pH (pHa) while variable changes in VO2 have been reported during alkali infusion. To compare metabolic with respiratory alkalosis 17 dogs were anesthetized with halothane and the... | Determinants of oxygen uptake during sodium bicarbonate infusion. Steady-state passive hyperventilation alkalosis produces a predictable increase in oxygen uptake (VO2) proportional to the change in arterial pH (pHa) while variable changes in VO2 have been reported during alkali infusion. To compare metabolic with resp... | [
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PMID:29868 | Intracellular pH and bicarbonate concentration in human muscle during recovery from exercise. | Eight subjects exercised on an ergometer until exhaustion. Femoral venous blood was analyzed for lactate, pyruvate, protein, electrolytes, and acid-base parameters. Muscle samples taken during the recovery period from m. quadriceps femoris were analyzed for water, electrolytes, lactate, and acid-labile CO2. Water conte... | Intracellular pH and bicarbonate concentration in human muscle during recovery from exercise. Eight subjects exercised on an ergometer until exhaustion. Femoral venous blood was analyzed for lactate, pyruvate, protein, electrolytes, and acid-base parameters. Muscle samples taken during the recovery period from m. quadr... | [
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PMID:29871 | On the governance system of university schools of nursing. | We find ourselves as schools of nursing in a period in which external pressures are increasing on the school and the university as the public and its representatives require better accounting for the resources as assigned to the university and access to the decisions as to the use of the resources. At the same time, ou... | On the governance system of university schools of nursing. We find ourselves as schools of nursing in a period in which external pressures are increasing on the school and the university as the public and its representatives require better accounting for the resources as assigned to the university and access to the dec... | [
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PMID:29877 | Professional interaction in academic health centers. | A survey was made of 106 medical schools to determine the presence of the academic health center concept in the United States. Five centers were selected for an in-depth study of the attitudes and behavior of health center students, faculty members, and administrators in the professions of dentistry, medicine, nursing ... | Professional interaction in academic health centers. A survey was made of 106 medical schools to determine the presence of the academic health center concept in the United States. Five centers were selected for an in-depth study of the attitudes and behavior of health center students, faculty members, and administrator... | [
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PMID:29878 | A systematic approach to module development. | The primary purpose of this article has been to outline and discuss the fourteen steps of the systematic approach to modular development utilized by the author. In addition, examples of each step have been included in an effort to illustrate each point. The article ends with a list of useful resources for the beginning... | A systematic approach to module development. The primary purpose of this article has been to outline and discuss the fourteen steps of the systematic approach to modular development utilized by the author. In addition, examples of each step have been included in an effort to illustrate each point. The article ends with... | [
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PMID:29885 | Time-dependent increase in the stability of collagen fibrils formed in vitro. I. Effects of pH and salt concentration on the dissolution of the fibrils. | The time-dependent increase in stability, as measured in terms of the rate of dissolution, of collagen fibrils formed in vitro from pepsin-treated collagen was significantly affected only by temperature, and not by either ionic strength or pH. This is in contrast with collagen fibril formation, a process which is great... | Time-dependent increase in the stability of collagen fibrils formed in vitro. I. Effects of pH and salt concentration on the dissolution of the fibrils. The time-dependent increase in stability, as measured in terms of the rate of dissolution, of collagen fibrils formed in vitro from pepsin-treated collagen was signifi... | [
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PMID:29886 | Chymotrypsin inhibitors from hemolymph of the silkworm, Bombyx mori. | Three new protease inhibitors were isolated and purified about 200-fold from hemolymph of silkworm larvae, Bombyx mori, using ion-exchange and affinity chromatography. Two of the three inhibitors were basic proteins (SCI-I had pI 9.4 and SCI-II had pI 9.6) and one was acidic (SCI-III had pI 4.0). The molecular weight o... | Chymotrypsin inhibitors from hemolymph of the silkworm, Bombyx mori. Three new protease inhibitors were isolated and purified about 200-fold from hemolymph of silkworm larvae, Bombyx mori, using ion-exchange and affinity chromatography. Two of the three inhibitors were basic proteins (SCI-I had pI 9.4 and SCI-II had pI... | [
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PMID:29887 | An isoelectric focusing study of acid phosphohydrolases in rat liver lysosomes. | The differentiation of rat liver lysosomal acid phosphatase, acid ATPase, acid phosphodiesterase, acid ribonuclease, and acid deoxyribonuclease was studied by isoelectric focusing. To prevent autolytic digestion, inhibitors of cathepsins and neuraminidase were used. The proportion of acidic forms of acid phosphatase, a... | An isoelectric focusing study of acid phosphohydrolases in rat liver lysosomes. The differentiation of rat liver lysosomal acid phosphatase, acid ATPase, acid phosphodiesterase, acid ribonuclease, and acid deoxyribonuclease was studied by isoelectric focusing. To prevent autolytic digestion, inhibitors of cathepsins an... | [
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PMID:29888 | Mechanisms of desorption and adsorption of liver cytosolic fumarase to cellular membranous components. | The cytosolic fumarase [EC 4.2.1.2[ of rat liver was bound, after dialysis, to the microsomal membrane in vitro. Binding of the enzyme was dependent on pH, and was facilitated in the pH range below 7.5. The binding reaction was completely inhibited by 0.5 mM fumarate, aurintricarboxylate or colchicine. The bound fumara... | Mechanisms of desorption and adsorption of liver cytosolic fumarase to cellular membranous components. The cytosolic fumarase [EC 4.2.1.2[ of rat liver was bound, after dialysis, to the microsomal membrane in vitro. Binding of the enzyme was dependent on pH, and was facilitated in the pH range below 7.5. The binding re... | [
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PMID:29889 | Ribonuclease H from rat liver. I. Partial purification and characterization of nuclear ribonuclease H1. | A ribonuclease H, an enzyme that specifically degrades the RNA moiety of RNA-DNA hybrid, has been partially purified from rat liver nuclei and characterized. Neither native or denatured DNA, nor single or double-stranded synthetic polyribonucleotides were degraded by the enzyme. The enzyme possesses a molecular weight ... | Ribonuclease H from rat liver. I. Partial purification and characterization of nuclear ribonuclease H1. A ribonuclease H, an enzyme that specifically degrades the RNA moiety of RNA-DNA hybrid, has been partially purified from rat liver nuclei and characterized. Neither native or denatured DNA, nor single or double-stra... | [
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PMID:29890 | Ribonuclease H from rat liver. II. Partial purification and characterization of cytosol ribonuclease H1. | We have detected in rat liver cytosol three enzymes (termed C-1, C-2, and C-3) which cleaved the RNA moiety of RNA-DNA hybrid. These enzymes were separated from each other by DEAE-Sephadex and Sephadex G-200 chromatography. C-1 and C-2 specifically act on the RNA moiety of RNA-DNA hybrid, while C-3 degrades single-stra... | Ribonuclease H from rat liver. II. Partial purification and characterization of cytosol ribonuclease H1. We have detected in rat liver cytosol three enzymes (termed C-1, C-2, and C-3) which cleaved the RNA moiety of RNA-DNA hybrid. These enzymes were separated from each other by DEAE-Sephadex and Sephadex G-200 chromat... | [
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PMID:29891 | Multiple attack in porcine pancreatic alpha-amylase-catalyzed hydrolysis of amylose studied with a fluorescence probe. | 1. A large fluorescence enhancement of 2-p-toluidinylnaphthalene-6-sulfonate (TNS) observed in the presence of amylose was utilized to monitor quantitatively the time course of porcine pancreatic alpha-amylase [EC 3.2.1.1] (PPA)-catalyzed hydrolysis of amylose with a number-average degree of polymerization of 16.8. 2. ... | Multiple attack in porcine pancreatic alpha-amylase-catalyzed hydrolysis of amylose studied with a fluorescence probe. 1. A large fluorescence enhancement of 2-p-toluidinylnaphthalene-6-sulfonate (TNS) observed in the presence of amylose was utilized to monitor quantitatively the time course of porcine pancreatic alpha... | [
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PMID:29892 | Subunit structure of islets-activating protein (IAP), a new protein isolated from the culture media of Bordetella pertussis. | The subunit structure was studied of islets-activating protein (IAP), a new protein recently isolated from the culture media of Bordetella pertussis and possessing a unique action, i.e., potentiating insulin secretory responses of animals, IAP dissociated into three subunits, F-1, F-2, and F-3, when incubated in 8M ure... | Subunit structure of islets-activating protein (IAP), a new protein isolated from the culture media of Bordetella pertussis. The subunit structure was studied of islets-activating protein (IAP), a new protein recently isolated from the culture media of Bordetella pertussis and possessing a unique action, i.e., potentia... | [
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PMID:29893 | Purification and characterization of L-pyrrolidonecarboxylate peptidase from Bacillus amyloiliquefaciens. | Microorganisms capable of producing L-pyrrolidonecarboxylate peptidase [L-pyrrolidonyl peptidase, EC 3.4.11.8] were screened and a strain of Bacillus amyloliquefaciens was chosen as one of the most potent producers of the enzyme. The enzyme was purified from lysozyme-lysate of the bacterial cells by salting out with am... | Purification and characterization of L-pyrrolidonecarboxylate peptidase from Bacillus amyloiliquefaciens. Microorganisms capable of producing L-pyrrolidonecarboxylate peptidase [L-pyrrolidonyl peptidase, EC 3.4.11.8] were screened and a strain of Bacillus amyloliquefaciens was chosen as one of the most potent producers... | [
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PMID:29894 | The stereochemical course of acetate activation by yeast acetyl-CoA synthetase. | The purified alpha-thiophosphate diastereoisomers of adenosine 5'-(1-thio)-triphosphate were used to study the stereochemical course of the reaction catalyzed by yeast acetyl-CoA synthetase. Asymmetrically labeled adenosine 5'-thiophosphate was formed from the "B" diastereoisomer of adenosine 5'-(1-thio)-triphosphate a... | The stereochemical course of acetate activation by yeast acetyl-CoA synthetase. The purified alpha-thiophosphate diastereoisomers of adenosine 5'-(1-thio)-triphosphate were used to study the stereochemical course of the reaction catalyzed by yeast acetyl-CoA synthetase. Asymmetrically labeled adenosine 5'-thiophosphate... | [
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PMID:29895 | The reversible binding of oxygen to sulfhemoglobin. | The O2 binding properties of sulfhemoglobin were studied. The oxygen tension required for half-saturation of sulfhemoglobin is more than 2 orders of magnitude higher than that for hemoglobin A. The binding of O2 exhibits an alkaline Bohr effect larger than that observed for hemoglobin, yet the Hill number is unity. Fro... | The reversible binding of oxygen to sulfhemoglobin. The O2 binding properties of sulfhemoglobin were studied. The oxygen tension required for half-saturation of sulfhemoglobin is more than 2 orders of magnitude higher than that for hemoglobin A. The binding of O2 exhibits an alkaline Bohr effect larger than that observ... | [
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PMID:29897 | Sea anemone toxin and scorpion toxin share a common receptor site associated with the action potential sodium ionophore. | Toxin II isolated from the sea anemone Anemonia sulcata enhances activation of the action potential sodium ionophore of electrically excitable neuroblastoma cells by veratridine and batrachotoxin. This heterotropic cooperative effect is identical to that observed previously with scorpion toxin but occurs at a 110-fold ... | Sea anemone toxin and scorpion toxin share a common receptor site associated with the action potential sodium ionophore. Toxin II isolated from the sea anemone Anemonia sulcata enhances activation of the action potential sodium ionophore of electrically excitable neuroblastoma cells by veratridine and batrachotoxin. Th... | [
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0.09393... |
PMID:29898 | Crystallographic studies on D-amino acid oxidase. | D-amino acid oxidase, a flavoprotein from hog kidneys, has been crystalized in two different forms. Orthorhombic prisms have been obtained from the enzyme.benzoate complex at pH 8.3; the space group is C2221 and the cell dimensions are a = 325A, b = 138.8 A, c = 200 A. At lower pH values, the enzyme crystallizes in tri... | Crystallographic studies on D-amino acid oxidase. D-amino acid oxidase, a flavoprotein from hog kidneys, has been crystalized in two different forms. Orthorhombic prisms have been obtained from the enzyme.benzoate complex at pH 8.3; the space group is C2221 and the cell dimensions are a = 325A, b = 138.8 A, c = 200 A. ... | [
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PMID:29900 | Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides. | Purified prostaglandin endoperoxides (PGG2 and PGH2) and hydroperoxides (15-OOH-PGE2) as well as fatty acid hydroperoxides (12-OOH-20:4, 15-00H-20:4, and 13-OOH-18:2) were examined as effectors of soluble splenic cell guanylate cyclase activity. The procedures described (in the miniprint supplement) for the preparation... | Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides. Purified prostaglandin endoperoxides (PGG2 and PGH2) and hydroperoxides (15-OOH-PGE2) as well as fatty acid hydroperoxides (12-OOH-20:4, 15-00H-20:4, and 13-OOH-18:2) were examined as effectors of soluble ... | [
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PMID:29902 | Biochemical studies of isolated glial (Müller) cells from the turtle retina. | A method has been developed for the preparation of large numbers of glial (Muller) cells from the turtle retina. After proteolytic dissociation of the retina, Muller cells were separated from retinal neurons by velocity sedimentation at unit gravity. Fractions containing >90 percent morphologically identifiable Mull... | Biochemical studies of isolated glial (Müller) cells from the turtle retina. A method has been developed for the preparation of large numbers of glial (Muller) cells from the turtle retina. After proteolytic dissociation of the retina, Muller cells were separated from retinal neurons by velocity sedimentation at unit g... | [
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PMID:29903 | Unusual responses of rat hepatic and renal peroxisomes to RMI 14, 514, a new hypolipidemic agent. | RMI 14, 514 ([5-tetradecycloxy]-2-furancarboxylic acid) represents a new class of hypolipidemic agents which cause unusual ultrastructural changes in liver of male rats and in selected peroxisomal enzymes in liver and kidney of both sexes. Among the principal ultrastructural changes in peroxisomes of male rat liver wer... | Unusual responses of rat hepatic and renal peroxisomes to RMI 14, 514, a new hypolipidemic agent. RMI 14, 514 ([5-tetradecycloxy]-2-furancarboxylic acid) represents a new class of hypolipidemic agents which cause unusual ultrastructural changes in liver of male rats and in selected peroxisomal enzymes in liver and kidn... | [
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PMID:29904 | Aspects of turnover and biogenesis of synaptic vesicles at locust neuromuscular junctions as revealed by zinc iodide-osmium tetroxide (ZIO) reacting with intravesicular SH-groups. | Retractor unguis nerve muscle preparations from the locust were subjected to the zinc iodide-osmium tetroxide reaction (ZIO) after pre-fixation in glutaraldehyde. Applied for 18 h at 4 degrees C in the dark, ZIO reacts at pH 4.2--4.0 fairly selectively with the matrix of synaptic vesicles. Approximately 53% of the vesi... | Aspects of turnover and biogenesis of synaptic vesicles at locust neuromuscular junctions as revealed by zinc iodide-osmium tetroxide (ZIO) reacting with intravesicular SH-groups. Retractor unguis nerve muscle preparations from the locust were subjected to the zinc iodide-osmium tetroxide reaction (ZIO) after pre-fixat... | [
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PMID:29905 | Ionic interactions between bovine chymotrypsinogen A and chondroitin sulfate A.B.C.. A possible model for molecular aggregation in zymogen granules. | The formation of large aggregates by ionic interactions between acidic glucosaminoglycans and cationic secretory proteins has been proposed as one of the critical steps in the concentration process in the condensing vacuoles of secretory cells. In this paper, this hypothesis was tested by studies on the interactions be... | Ionic interactions between bovine chymotrypsinogen A and chondroitin sulfate A.B.C.. A possible model for molecular aggregation in zymogen granules. The formation of large aggregates by ionic interactions between acidic glucosaminoglycans and cationic secretory proteins has been proposed as one of the critical steps in... | [
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PMID:29906 | Red cell aging. II. Anomalous electrophoretic properties of neuraminidase treated human erythrocytes. | Desialylation of human red blood cells (RBC) by Vibrio cholerae neuraminidase (VCN) was found to produce cells with electrophoretic properties which were inconsistent with the view of simple loss of N-acetylneuraminic acid (NANA) as the sole effect of VCN treatment. Modification of human RBC with 50--350 U VCN/10(10) R... | Red cell aging. II. Anomalous electrophoretic properties of neuraminidase treated human erythrocytes. Desialylation of human red blood cells (RBC) by Vibrio cholerae neuraminidase (VCN) was found to produce cells with electrophoretic properties which were inconsistent with the view of simple loss of N-acetylneuraminic ... | [
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PMID:29907 | Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam. | This paper describes a rapid and sensitive method for analysis of lorazepam and its glucuronide metabolite in plasma and urine following therapeutic doses of lorazepam in humans. After addition of the structurally related benzodiazepine derivative, oxazepam, as the internal standard, 1-ml samples of plasma or urine are... | Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam. This paper describes a rapid and sensitive method for analysis of lorazepam and its glucuronide metabolite in plasma and urine following therapeutic doses of lorazepam in hum... | [
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PMID:29908 | Isoelectric focusing of the phosphoprotein of rat-incisor dentin in ampholine and acid pH gradients. Evidence for carrier ampholyte-protein complexes. | Rat-incisor phosphoprotein (RIP) has been subjected to isoelectric focusing at 4 degrees in (a) an Ampholine pH gradient of 2.5-4 and (b) an acid pH gradient created by electrolysis of a system of acids and acidic ampholytes and covering the pH range 0.5-3.5. In the Ampholine gradient, the RIP unexpectedly formed sever... | Isoelectric focusing of the phosphoprotein of rat-incisor dentin in ampholine and acid pH gradients. Evidence for carrier ampholyte-protein complexes. Rat-incisor phosphoprotein (RIP) has been subjected to isoelectric focusing at 4 degrees in (a) an Ampholine pH gradient of 2.5-4 and (b) an acid pH gradient created by ... | [
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PMID:29909 | Preparation of prereduced anaerobically sterilized media and their use in cultivation of anaerobic bacteria. | Several modifications of the roll-tube method have made it simpler for routine use in the isolation and growth of anaerobic bacteria. These include use of a check valve for the production of prereduced anaerobically sterilized media; a Salvarsan tube under oxygen-free gas pressure for the dispensing of molten prereduce... | Preparation of prereduced anaerobically sterilized media and their use in cultivation of anaerobic bacteria. Several modifications of the roll-tube method have made it simpler for routine use in the isolation and growth of anaerobic bacteria. These include use of a check valve for the production of prereduced anaerobic... | [
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PMID:29910 | Immunoelectrophoresis for detection of polysaccharides in immune complexes. | A procedure for detecting pneumococcal capsular polysaccharides in immune complexes is described. Separation of antigen from immune complexes is achieved by electrophoresis at 56 degrees C. | Immunoelectrophoresis for detection of polysaccharides in immune complexes. A procedure for detecting pneumococcal capsular polysaccharides in immune complexes is described. Separation of antigen from immune complexes is achieved by electrophoresis at 56 degrees C. | [
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PMID:29911 | Primary isolation media for Legionnaires disease bacterium. | Yolk sac suspensions infected with the Legionnaires disease bacterium (LDB) were plated onto 17 different bacteriological agar media. The LDB grew only on Mueller-Hinton agar supplemented with 1% Iso Vitale X and 1% hemoglobin (MH-IH). This medium was subsequently analyzed to determine the components required to suppor... | Primary isolation media for Legionnaires disease bacterium. Yolk sac suspensions infected with the Legionnaires disease bacterium (LDB) were plated onto 17 different bacteriological agar media. The LDB grew only on Mueller-Hinton agar supplemented with 1% Iso Vitale X and 1% hemoglobin (MH-IH). This medium was subseque... | [
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PMID:29912 | The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. | NH4+ caused a dose-related, rapid, and reversible inhibition of glucose-stimulated insulin release by isolated rat islets. It also inhibited glyceraldehyde-, Ba2+-, and sulfonylurea-stimulated insulun secretion. NH4+ failed to affect glucose utilization and oxidation, glucose-stimulated proinsulin biosynthesis, the con... | The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. NH4+ caused a dose-related, rapid, and reversible inhibition of glucose-stimulated insulin release by isolated rat islets. It also inhibited glyceraldehyde-, Ba2+-, and sulfonylurea-stimulated ins... | [
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PMID:29915 | Reproduction and breeding of goats. | Reproduction and genetics of the goat are reviewed with a view of increasing their contribution to mankind. The goat contributes most in tropical regions (within 30 degrees of the equator). The most important product from the goat is milk with meat a close second. Other products are minor. Reproductive rate is a proble... | Reproduction and breeding of goats. Reproduction and genetics of the goat are reviewed with a view of increasing their contribution to mankind. The goat contributes most in tropical regions (within 30 degrees of the equator). The most important product from the goat is milk with meat a close second. Other products are ... | [
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PMID:29919 | Efficacy of intravenous pretesting and antihistamine prophylaxis in radiocontrast media--sensitive patients. | Intravenous pretesting with radiocontrast media (RCM) was performed in 204 RCM-sensitive patients considered for repeat contrast radiography. Group 1 had vague histories of prior anaphylactoid reaction and negative pretests, and 2 of 41 (4.9%) had reactions upon contrast radiography. Groups 2 to 5 had definite historie... | Efficacy of intravenous pretesting and antihistamine prophylaxis in radiocontrast media--sensitive patients. Intravenous pretesting with radiocontrast media (RCM) was performed in 204 RCM-sensitive patients considered for repeat contrast radiography. Group 1 had vague histories of prior anaphylactoid reaction and nega... | [
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PMID:29925 | [Therapeutics basis of threatened abortions (author's transl)]. | The diverse hormonal and vascular medications are studied in the way of their mechanism of action, of their efficiency and their side effects on the mother as well as on the fetus. Neither definite argument, nor important statistical study has been made after elimination of all genetics and chromosomic anomalies. beta-... | [Therapeutics basis of threatened abortions (author's transl)]. The diverse hormonal and vascular medications are studied in the way of their mechanism of action, of their efficiency and their side effects on the mother as well as on the fetus. Neither definite argument, nor important statistical study has been made af... | [
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PMID:29927 | Frequencies of pneumococcal types causing serious infections in patients admitted to the Radcliffe Infirmary, Oxford, 1969-77. | During a 7 1/2 year period pneumococci were isolated from body fluids of 124 patients at the Radcliffe Infirmary, Oxford -72 with pneumonia, 26 with meningitis and 26 with other serious infections. Eighty-one (65%) of the patients were over 50, and 33 (27%) were over 70 years old. Of the 124 pneumococcal strains 104 (8... | Frequencies of pneumococcal types causing serious infections in patients admitted to the Radcliffe Infirmary, Oxford, 1969-77. During a 7 1/2 year period pneumococci were isolated from body fluids of 124 patients at the Radcliffe Infirmary, Oxford -72 with pneumonia, 26 with meningitis and 26 with other serious infecti... | [
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PMID:29928 | Effect of splenectomy on the expression of regulatory T cell activity. | The effect of adult splenectomy on the expression of suppressor and amplifier T cell activity was examined with respect to the serum antibody response to Type III pneumococcal polysaccharide (SSS-III) by using a sensitive radioimmunoassay. Suppressor T cell activity, as measured by the degree of low-dose paralysis indu... | Effect of splenectomy on the expression of regulatory T cell activity. The effect of adult splenectomy on the expression of suppressor and amplifier T cell activity was examined with respect to the serum antibody response to Type III pneumococcal polysaccharide (SSS-III) by using a sensitive radioimmunoassay. Suppresso... | [
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PMID:29929 | An immunoprecipitation-dissociation technique for large scale antibody purification and an antigen consumption electroimmunoassay for antibody quantitation. A model study with antibodies to pregnancy zone protein. | A simple immunoprecipitation--dissociation technique for large scale purification of antibodies is described, which comprises selective denaturation of the antigen and recovery of the antibody fraction by exclusion chromatography at low pH. Its use is illustrated by the purification of antibodies to pregnancy zone prot... | An immunoprecipitation-dissociation technique for large scale antibody purification and an antigen consumption electroimmunoassay for antibody quantitation. A model study with antibodies to pregnancy zone protein. A simple immunoprecipitation--dissociation technique for large scale purification of antibodies is describ... | [
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PMID:29930 | Organic solvents and temperature effects on desorption from immunoadsorbents. DNP-BSA anti-DNP as a model. | Conditions for desorbing a DNP carrier from its immunoadsorbent were studied in various hydro-organic media at different pHs and temperatures, including the sub-zero range. It appeared that DNP--anti-DNP interaction is the result of a balance between various bonds and the best result (95% yield) was obtained in hydro-o... | Organic solvents and temperature effects on desorption from immunoadsorbents. DNP-BSA anti-DNP as a model. Conditions for desorbing a DNP carrier from its immunoadsorbent were studied in various hydro-organic media at different pHs and temperatures, including the sub-zero range. It appeared that DNP--anti-DNP interacti... | [
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PMID:29934 | The effect of calcium and magnesium on the spontaneous release of transmitter at insect motor nerve terminals. | 1. The effect of the extracellular calcium and magnesium concentrations and calcium ionophore, X-537A, on the frequency of miniature excitatory post-synaptic potentials (MEPSPs) was studied in cockroach leg muscle fibres. 2. The frequency of MEPSPs increased as the calcium concentration was increased from 0.1 to 10 mM.... | The effect of calcium and magnesium on the spontaneous release of transmitter at insect motor nerve terminals. 1. The effect of the extracellular calcium and magnesium concentrations and calcium ionophore, X-537A, on the frequency of miniature excitatory post-synaptic potentials (MEPSPs) was studied in cockroach leg mu... | [
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PMID:29935 | Secretion of lysosomal hydrolases by stimulated and nonstimulated macrophages. | Peritoneal macrophages were obtained from untreated mice and from mice treated with thioglycollate medium (TA), proteose peptone medium (PP), or a suspension of streptococcus A cell wall material (SA). The biochemical and secretory properties of these cells in long term cultures (up to 2 wk) were compared. TA-elicited ... | Secretion of lysosomal hydrolases by stimulated and nonstimulated macrophages. Peritoneal macrophages were obtained from untreated mice and from mice treated with thioglycollate medium (TA), proteose peptone medium (PP), or a suspension of streptococcus A cell wall material (SA). The biochemical and secretory propertie... | [
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PMID:29936 | T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. | W3/25 antibody is the monoclonal product of a hybrid cell resulting from the fusion of a mouse myeloma cell line with spleen cells from a mouse immunized with rat thymocytes. Pure clones have been derived, and segregants free of parental myeloma chains have been isolated. Previous studies have shown that this antibody ... | T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. W3/25 antibody is the monoclonal product of a hybrid cell resulting from the fusion of a mouse myeloma cell line with spleen cells from a mouse immunized with rat thymocytes. Pure clones have been derived, and se... | [
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PMID:29937 | Demonstration of opsonic activity and in vivo protection against group B streptococci type III by Streptococcus pneumoniae type 14 antisera. | The present studies demonstrate that antisera directed against Streptococcus pneumoniae type 14 is opsonic for group B streptococci type III in a neutrophile-mediated bactericidal assay. Specificity was demonstrated by the observations that group B streptococci type III and S. pneumoniae type 14 adsorbed the opsonic ac... | Demonstration of opsonic activity and in vivo protection against group B streptococci type III by Streptococcus pneumoniae type 14 antisera. The present studies demonstrate that antisera directed against Streptococcus pneumoniae type 14 is opsonic for group B streptococci type III in a neutrophile-mediated bactericidal... | [
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PMID:29938 | In vitro studies on lymphocyte differentiation. I. Long term in vitro culture of cells giving rise to functional lymphocytes in irradiated mice. | In vitro cultures of mouse bone marrow cells, maintained for periods up to 7 wk, were shown to contain cells able to repopulate irradiated hosts with T and B lymphocytes. The lymphocytes were fully functional and there did not appear to be any gross restriction of their receptor repertoire. The cultured cells reconstit... | In vitro studies on lymphocyte differentiation. I. Long term in vitro culture of cells giving rise to functional lymphocytes in irradiated mice. In vitro cultures of mouse bone marrow cells, maintained for periods up to 7 wk, were shown to contain cells able to repopulate irradiated hosts with T and B lymphocytes. The ... | [
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PMID:29953 | Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity. | Lipolytic activity was studied in gastric aspirates of 13 premature infants of birth weight 1,050 to 1,786 gm. All infants received a diet of infant formula fed by gastric tube. Gastric aspirates were collected after irrigating the stomach with 2 to 5 ml sterile saline before regular feeding. Lipolytic activity, tested... | Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity. Lipolytic activity was studied in gastric aspirates of 13 premature infants of birth weight 1,050 to 1,786 gm. All infants received a diet of infant formula fed by gastric tube. Gastric aspirates were collected after irrigating th... | [
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PMID:29954 | Pharmacokinetics of flunitrazepam following single- and multiple-dose oral administration to healthy human subjects. | Healthy human subjects received single and multiple oral doses of flunitrazepam. Absorption and disposition were first order and reproducible from administration. The oral doses were virtually completely available to the liver, and elimination from the body occurred entirely via metabolism. Assuming the liver to be the... | Pharmacokinetics of flunitrazepam following single- and multiple-dose oral administration to healthy human subjects. Healthy human subjects received single and multiple oral doses of flunitrazepam. Absorption and disposition were first order and reproducible from administration. The oral doses were virtually completely... | [
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PMID:29955 | Instability of digoxin in acid medium using a nonisotopic method. | A selective nonisotopic assay was used to investigate the digoxin hydrolysis rates at 37 +/- 0.1 degrees over the pH 1.1--2.2 range. The colorimetric method adopted is based on the use of a xanthydrol reagent after extraction with chloroform. The spectrofluorometric method specified in the dissolution test for digoxin ... | Instability of digoxin in acid medium using a nonisotopic method. A selective nonisotopic assay was used to investigate the digoxin hydrolysis rates at 37 +/- 0.1 degrees over the pH 1.1--2.2 range. The colorimetric method adopted is based on the use of a xanthydrol reagent after extraction with chloroform. The spectro... | [
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PMID:29956 | Ditheophylline succinate: transfer of theophylline across everted rat intestinal sacs. | The cumulative theophylline transfer rate across 10-cm everted rat intestinal sacs incubated at 37 degrees in pH 7.4 Krebs phosphate buffer was determined. A suspension of ditheophylline succinate ( a potential prodrug of theophylline) and a solution of theophylline at equimolar concentration were evaluated to determin... | Ditheophylline succinate: transfer of theophylline across everted rat intestinal sacs. The cumulative theophylline transfer rate across 10-cm everted rat intestinal sacs incubated at 37 degrees in pH 7.4 Krebs phosphate buffer was determined. A suspension of ditheophylline succinate ( a potential prodrug of theophyllin... | [
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PMID:29957 | Distribution of camazepam in rats and mice. | Camazepam, 5 mg/kg iv, was injected in rats and mice to study its distribution in the blood and brain. Peak blood levels were about 0.9 microgram/ml in rats and 0.6 microgram/ml in mice. Peak brain levels were about 1.5 microgram/g in rats and 0.8 microgram/g in mice. The apparent blood half-life of camazepam was 9 min... | Distribution of camazepam in rats and mice. Camazepam, 5 mg/kg iv, was injected in rats and mice to study its distribution in the blood and brain. Peak blood levels were about 0.9 microgram/ml in rats and 0.6 microgram/ml in mice. Peak brain levels were about 1.5 microgram/g in rats and 0.8 microgram/g in mice. The app... | [
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PMID:29958 | Inhibition of epinephrine oxidation in weak alkaline solutions. | The effect of sodium metabisulfite and cysteine on the oxidation of epinephrine in weak alkaline solutions was studied. The fluorescent intensity of the reacting mixture also was measured. Sodium metabisulfite in 2 x 10(-3) M NaOH at concentrations lower than 3 x 10(-5) M had no effect on epinephrine oxidation; however... | Inhibition of epinephrine oxidation in weak alkaline solutions. The effect of sodium metabisulfite and cysteine on the oxidation of epinephrine in weak alkaline solutions was studied. The fluorescent intensity of the reacting mixture also was measured. Sodium metabisulfite in 2 x 10(-3) M NaOH at concentrations lower t... | [
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PMID:29960 | The effect of neuroleptics on acetylcholine concentration and choline uptake in striatum: Implications for regulation of acetylcholine metabolism. | It has previously been shown that neuroleptic drugs block an apparently inhibitory influence of dopamine on cholinergic interneurons in striatum, thereby increasing acetylcholine turnover. In this study, systemic administration of the neuroleptic, fluphenazine, decreased the acetylcholine content in the striatum but no... | The effect of neuroleptics on acetylcholine concentration and choline uptake in striatum: Implications for regulation of acetylcholine metabolism. It has previously been shown that neuroleptic drugs block an apparently inhibitory influence of dopamine on cholinergic interneurons in striatum, thereby increasing acetylch... | [
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PMID:29961 | The effects of several narcotic analgesics on brain levels of 3-methoxy-4-hydroxyphenylethylene glycol sulfate in the rat. | The acute administration of levorphanol, morphine, anileridine, methadone, cyclazocine and pentazocine was found to increase brain levels of 3-methoxy-4-hydroxyphenylethylene glycol sulfate (MOPEG-SO4) in rats. Drug-induced increases in brain levels of this norepinephrine metabolite were dose-dependent and peak drug ef... | The effects of several narcotic analgesics on brain levels of 3-methoxy-4-hydroxyphenylethylene glycol sulfate in the rat. The acute administration of levorphanol, morphine, anileridine, methadone, cyclazocine and pentazocine was found to increase brain levels of 3-methoxy-4-hydroxyphenylethylene glycol sulfate (MOPEG-... | [
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PMID:29962 | In vivo desensitization to beta receptor mediated bronchodilator drugs in the rat: decreased beta receptor affinity. | When tracheas were isolated from rats pretreated with isoproterenol (ISO) or terbutaline, they were found to be considerably less sensitive to the relaxant action of ISO than tracheas which were isolated from saline-pretreated rats. The dissociation constant (Kb) for the propranolol-beta receptor complex was determined... | In vivo desensitization to beta receptor mediated bronchodilator drugs in the rat: decreased beta receptor affinity. When tracheas were isolated from rats pretreated with isoproterenol (ISO) or terbutaline, they were found to be considerably less sensitive to the relaxant action of ISO than tracheas which were isolated... | [
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PMID:29963 | Post-tetanic enhancement of stimulus-induced muscarinic afterdischarge in the rat superior cervical ganglion. | The enhancement of asynchronous muscarinic ganglionic firing which follows a preganglionic nerve stimulus volley by high frequency repetitive conditioning stimuli was studied in the rat isolated superior cervical ganglion. Muscarinic afterdischarge which occurred in chlorisondamine-blocked ganglia was enhanced for up t... | Post-tetanic enhancement of stimulus-induced muscarinic afterdischarge in the rat superior cervical ganglion. The enhancement of asynchronous muscarinic ganglionic firing which follows a preganglionic nerve stimulus volley by high frequency repetitive conditioning stimuli was studied in the rat isolated superior cervic... | [
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PMID:29965 | Effect of luminal pH on acid secretion from Heidenhain pouches evoked by topical and parenteral stimulants. | 1. An apparatus for intragastric titration has been devised and its validity tested. Both when attached to a beaker simulating a pouch and when attached to a pouch whose secretion was suppressed by infusing cimetidine, the apparatus accurately measured added acid when the endpoint setting was between pH 3.0 and 9.0. At... | Effect of luminal pH on acid secretion from Heidenhain pouches evoked by topical and parenteral stimulants. 1. An apparatus for intragastric titration has been devised and its validity tested. Both when attached to a beaker simulating a pouch and when attached to a pouch whose secretion was suppressed by infusing cimet... | [
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PMID:29966 | Renal bicarbonate reabsorption in the new-born dog. | 1. Renal bicarbonate reabsorption was measured in thirty new-born dogs 2-27 days of age. Plasma bicarbonate was varied in the puppies by exchanging their blood with blood containing high levels of bicarbonate and low levels of chloride.2. The exchange transfusion resulted in increases of plasma pH, P(CO2) and bicarbona... | Renal bicarbonate reabsorption in the new-born dog. 1. Renal bicarbonate reabsorption was measured in thirty new-born dogs 2-27 days of age. Plasma bicarbonate was varied in the puppies by exchanging their blood with blood containing high levels of bicarbonate and low levels of chloride.2. The exchange transfusion resu... | [
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PMID:29969 | Glutamine and glutamic acid uptake by rat renal brushborder membrane vesicles. | Glutamine uptake by rat renal brushborder vesicles occurred via two distinct saturable processes with Km values of 0.145 and 8.5 mM which were stimulated by both ionic and sodium gradients with a pH optimum of 6.8--7.1. Glutamic acid uptake also occurred by a two-component system with Km values of 0.016 and 3.60 mM. Bo... | Glutamine and glutamic acid uptake by rat renal brushborder membrane vesicles. Glutamine uptake by rat renal brushborder vesicles occurred via two distinct saturable processes with Km values of 0.145 and 8.5 mM which were stimulated by both ionic and sodium gradients with a pH optimum of 6.8--7.1. Glutamic acid uptake ... | [
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PMID:29970 | Cryptorchidism and testicular neoplasia. | A retrospective review of 20 cases of testicular neoplasia in cryptorchid patients is presented. These cases serve to emphasize the need for more effective diagnosis and management of the undescended testis. The various clinical presentations, diagnostic modalities, prognostic indicators, and types of management are re... | Cryptorchidism and testicular neoplasia. A retrospective review of 20 cases of testicular neoplasia in cryptorchid patients is presented. These cases serve to emphasize the need for more effective diagnosis and management of the undescended testis. The various clinical presentations, diagnostic modalities, prognostic i... | [
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PMID:29971 | Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury. | The effect of soft-tissue trauma was studied in dogs. Following injuries to the hind leg an aggregation of thrombocytes in blood and trapping in the lung was noted. Injury was initially followed by leukopenia and later by leukocytosis. Early hemolysis of red cells was observed. The injury was accompanied by complement ... | Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury. The effect of soft-tissue trauma was studied in dogs. Following injuries to the hind leg an aggregation of thrombocytes in blood and trapping in the lung was noted. Injury was initially followed by leukopenia a... | [
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PMID:29973 | The congenitally dilated prostatic utricle. | A case of utricular dilatation in a child with recurrent urinary tract infection and associated genitourinary anomalies is presented. The embryology of the utricle and the relationship of the dilated utricle to the müllerian duct regression factor are discussed. Clinical sequelae, diagnosis and management are outlined ... | The congenitally dilated prostatic utricle. A case of utricular dilatation in a child with recurrent urinary tract infection and associated genitourinary anomalies is presented. The embryology of the utricle and the relationship of the dilated utricle to the müllerian duct regression factor are discussed. Clinical sequ... | [
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PMID:29976 | Cardiovascular effects of isoproterenol and possible antagonistic actions of propranolol and perhexiline. | A beta-adrenergic blocking activity of perhexiline was compared with that of propanolol. In the Langendorff's preparation of rabbits, canine heart-lung preparations, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular functions, which were effe... | Cardiovascular effects of isoproterenol and possible antagonistic actions of propranolol and perhexiline. A beta-adrenergic blocking activity of perhexiline was compared with that of propanolol. In the Langendorff's preparation of rabbits, canine heart-lung preparations, open-chest dog preparations and hind-limbs of do... | [
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PMID:29982 | [Gamma-glutamyl transpeptidase activity in ischemic heart disease]. | The blood plasma gamma-glutamyltranspeptidase (GGTP) activity was studied in 133 patients with macrofocal myocardial infarction, in 40 patients with microfocal myocardial infarction, in 30 patients with angina pectoris, and in 75 patients with cardiosclerosis and congestive cardiac failure. The activity of the enzyme i... | [Gamma-glutamyl transpeptidase activity in ischemic heart disease]. The blood plasma gamma-glutamyltranspeptidase (GGTP) activity was studied in 133 patients with macrofocal myocardial infarction, in 40 patients with microfocal myocardial infarction, in 30 patients with angina pectoris, and in 75 patients with cardiosc... | [
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PMID:29993 | Physicians' assistants on a university cardiothoracic surgical service. A five-year update. | In 1973 two physicans' assistants (P.A.'s) were employed on a cardiothoracic surgical service at Emory University Hospital. In 1974 our initial experience with these paramedical personnel was presented to this Association. Since that time eight additional P.A.'s have been added to our service. They are now employed in ... | Physicians' assistants on a university cardiothoracic surgical service. A five-year update. In 1973 two physicans' assistants (P.A.'s) were employed on a cardiothoracic surgical service at Emory University Hospital. In 1974 our initial experience with these paramedical personnel was presented to this Association. Since... | [
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PMID:29994 | Postperfusion lung syndrome. Comparison of Travenol bubble and membrane oxygenators. | To examine the role of the oxygenator in the postperfusion lung syndrome, we studied 16 patients undergoing aorta-coronary bypass with a bubble oxygenator and 14 similar patients with a membrane oxygenator both before and for 2 days after the operation. To maintain the same pulmonary artery occluded pressure and hemogl... | Postperfusion lung syndrome. Comparison of Travenol bubble and membrane oxygenators. To examine the role of the oxygenator in the postperfusion lung syndrome, we studied 16 patients undergoing aorta-coronary bypass with a bubble oxygenator and 14 similar patients with a membrane oxygenator both before and for 2 days af... | [
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PMID:29995 | Protection of the ischemic myocardium. Volume-duration relationships and the efficacy of myocardial infusates. | In studies in the isolated rat heart that were designed to optimize the composition of the infusion conditions for a cardioplegic protective solutuin, we have observed a complex relationship between the duration and volume of infusion and the extent of tissue protection. Our results would indicate that solutions, such ... | Protection of the ischemic myocardium. Volume-duration relationships and the efficacy of myocardial infusates. In studies in the isolated rat heart that were designed to optimize the composition of the infusion conditions for a cardioplegic protective solutuin, we have observed a complex relationship between the durati... | [
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PMID:29997 | New health professional practice patterns. | Career patterns and practice correlates of 143 New Health Professionals (NHPs) educated at one institution are studied to determine similarities among different types of practitioners (Health Associates and Nurse Practitioners). Employment since graduation has been high with low job turnover. Nurse Practitioners (NPs) ... | New health professional practice patterns. Career patterns and practice correlates of 143 New Health Professionals (NHPs) educated at one institution are studied to determine similarities among different types of practitioners (Health Associates and Nurse Practitioners). Employment since graduation has been high with l... | [
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PMID:30009 | [Biochemical and pathophysiological aspects of alcohol metabolism (author's transl)]. | The metabolism of ethanol to acetaldehyde proceeds in the liver via alcohol dehydrogenase (ADH) and the microsomal ethanol oxidizing system (MEOS), whereas catalase plays no significant role. ADH is localized in the cytosol, required required NAD+ as cofactor and exhibits a pH optimum in the alkaline range and a Km of ... | [Biochemical and pathophysiological aspects of alcohol metabolism (author's transl)]. The metabolism of ethanol to acetaldehyde proceeds in the liver via alcohol dehydrogenase (ADH) and the microsomal ethanol oxidizing system (MEOS), whereas catalase plays no significant role. ADH is localized in the cytosol, required ... | [
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PMID:30019 | The regulations of renal ammoniagenesis in the rat by extracellular factors. I. The combined effects of acidosis and physiologic fuels. | Substrate oxidation by rat kidney slices regulates renal ammoniagenesis from glutamine. At concentrations close to those expected in plasma, lactate alone, or combined with other renal fuels, inhibits ammoniagenesis markedly; glucose and citrate decrease ammoniagenesis slightly. However, lactate, citrate, and glucose i... | The regulations of renal ammoniagenesis in the rat by extracellular factors. I. The combined effects of acidosis and physiologic fuels. Substrate oxidation by rat kidney slices regulates renal ammoniagenesis from glutamine. At concentrations close to those expected in plasma, lactate alone, or combined with other renal... | [
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PMID:30020 | Effect of starvation, nutriment replacement, and hypothyroidism on in vitro hepatic T4 to T3 conversion in the rat. | To evaluate the effect of starvation, oral and i.v. nutriments, and hypothyroidism on the peripheral conversion of thyroxine (T4) to 3,3', 5-triiodothyronine (T3) in the rat and mouse, an in vitro system for assessing T4 conversion to T3 by fresh liver homogenates was used. A 2-day starvation in the rat reduced hepatic... | Effect of starvation, nutriment replacement, and hypothyroidism on in vitro hepatic T4 to T3 conversion in the rat. To evaluate the effect of starvation, oral and i.v. nutriments, and hypothyroidism on the peripheral conversion of thyroxine (T4) to 3,3', 5-triiodothyronine (T3) in the rat and mouse, an in vitro system ... | [
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PMID:30022 | [Mechanism of the oxidation of divalent iron and manganese by iron bacteria developing in a neutral acidic medium]. | The paper confirms the existence of a peroxide mechanism involved in oxidation of iron and manganeses by the most typical iron bacteria growing at neutral acidity of the medium. Oxidation of bivalent iron and manganese is accomplished by the simultaneous action of catalase and hydrogen peroxide produced in the respirat... | [Mechanism of the oxidation of divalent iron and manganese by iron bacteria developing in a neutral acidic medium]. The paper confirms the existence of a peroxide mechanism involved in oxidation of iron and manganeses by the most typical iron bacteria growing at neutral acidity of the medium. Oxidation of bivalent iron... | [
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PMID:30023 | [Effect of the redox potential on the growth of aerobic microorganisms]. | The effect of redox potential was studied on the growth of the following aerobic microorganisms: Candida utilis, Bacillus megaterium, Pseudomonas fluorescens. The action of oxidizing agents (K3Fe(CN)6, KIO3, K2Cr207 and KMnO4) and reducing agents (ascorbic acid, sodium thioglycolate, K4Fe (CN)6 and Na2S2O3) on the grow... | [Effect of the redox potential on the growth of aerobic microorganisms]. The effect of redox potential was studied on the growth of the following aerobic microorganisms: Candida utilis, Bacillus megaterium, Pseudomonas fluorescens. The action of oxidizing agents (K3Fe(CN)6, KIO3, K2Cr207 and KMnO4) and reducing agents ... | [
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PMID:30025 | [Alcohol dehydrogenase activity of the subcellular fractions of Torulopsis candida yeasts grown on glucose and hexadecane]. | The activity of alcohol dehydrogenase was compared in subcellular fractions of Torulopsis candida grown on glucose ("glucose cells") and on hexadecane ("hexadecane cells"). Two groups of alcohol dehydrogenases (ADH) were found to be present in the cells: (1) soluble ADH located in the cytosol and (2) ADH bound to the m... | [Alcohol dehydrogenase activity of the subcellular fractions of Torulopsis candida yeasts grown on glucose and hexadecane]. The activity of alcohol dehydrogenase was compared in subcellular fractions of Torulopsis candida grown on glucose ("glucose cells") and on hexadecane ("hexadecane cells"). Two groups of alcohol d... | [
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PMID:30034 | [A field study with the combination of Pindolol and Clopamid in antihpertensive therapy (author's transl)]. | In a field study comprising 678 patients with arterial hypertension efficacy and tolerance of the stable combination VKB 105 consisting of 10 mg Pindolol (Visken) and 5 mg Clopamid (Brinaldix) were investigated. Treatment with 1--2 tablets of VKB per day resulted in a successful therapy in 94% of all patients correspon... | [A field study with the combination of Pindolol and Clopamid in antihpertensive therapy (author's transl)]. In a field study comprising 678 patients with arterial hypertension efficacy and tolerance of the stable combination VKB 105 consisting of 10 mg Pindolol (Visken) and 5 mg Clopamid (Brinaldix) were investigated. ... | [
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0.022226188331842422,
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0.06500157713890076,
0.016... |
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