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PMID:6971 | Fractionation of serum transcobalamins on charged cellulose filters. | A simple and rapid fractionation procedure of the three transcobalamins, TCI, TCII, and TCII, of human serum was achieved by filtration through a stack of charged cellulose filters composed of one cellulose-nitrate and three DEAE-cellulose (DE-81) disks. A reaction mixture containing microliter amounts of serum was inc... | Fractionation of serum transcobalamins on charged cellulose filters. A simple and rapid fractionation procedure of the three transcobalamins, TCI, TCII, and TCII, of human serum was achieved by filtration through a stack of charged cellulose filters composed of one cellulose-nitrate and three DEAE-cellulose (DE-81) dis... | [
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PMID:6972 | The inhibition by ADP of NADPH-supported adrenal steroid 11beta-hydroxylation. | The 11beta-hydroxylation of deoxycorticosterone to form corticosterone in adrenal mitochondria has been found to be inhibited by ADP and ATP, with ADP being the more inhibitory of the two. The evidence suggests that the ADP directly affects the enzyme system. | The inhibition by ADP of NADPH-supported adrenal steroid 11beta-hydroxylation. The 11beta-hydroxylation of deoxycorticosterone to form corticosterone in adrenal mitochondria has been found to be inhibited by ADP and ATP, with ADP being the more inhibitory of the two. The evidence suggests that the ADP directly affects ... | [
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PMID:6973 | The startle response in rats: effect of ethanol. | The effects of acute and chronic ethanol intake on the startle response was examined in male rats. Ethanol given IP produced a dose-dependent decrease in the amplitude of the startle response measured 30 min later. With a dose of 1 g/kg, the effect was evident at 15 min and had recovered substantially by 60 min. The ef... | The startle response in rats: effect of ethanol. The effects of acute and chronic ethanol intake on the startle response was examined in male rats. Ethanol given IP produced a dose-dependent decrease in the amplitude of the startle response measured 30 min later. With a dose of 1 g/kg, the effect was evident at 15 min ... | [
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PMID:6974 | Plasma angiotensin II levels and water intake following beta-adrenergic stimulation, hypovolemia, cellular dehydration and water deprivation. | A comparison of the effects of extracellular and intracellular thirst stimuli on plasma levels of angiotensin II was made in rats. The administration of polyethylene glycol and isoproterenol elicited a strong drinking response and resulted in a significant increase in plasma angiotensin II. There was a significant corr... | Plasma angiotensin II levels and water intake following beta-adrenergic stimulation, hypovolemia, cellular dehydration and water deprivation. A comparison of the effects of extracellular and intracellular thirst stimuli on plasma levels of angiotensin II was made in rats. The administration of polyethylene glycol and i... | [
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PMID:6975 | Prevention of memory loss following puromycin treatment. | Female C57BL/6J mice were trained on a one trial passive avoidance response. Twenty-four hours later, they were treated with puromycin in combination with either 2.0 or 10.0 mg/kg of amphetamine, 0.3 mg/kg of strychnine, or 20.0 or 50.0 mg/kg of pentylenetetrazol. Tests one week after training revealed that treatment w... | Prevention of memory loss following puromycin treatment. Female C57BL/6J mice were trained on a one trial passive avoidance response. Twenty-four hours later, they were treated with puromycin in combination with either 2.0 or 10.0 mg/kg of amphetamine, 0.3 mg/kg of strychnine, or 20.0 or 50.0 mg/kg of pentylenetetrazol... | [
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PMID:6976 | Selective depleting effect of syrosingopine on brain catecholamine levels with relation to morphine analgesia in the rat. | Reserpine was the most potent, rescinnamine the next and syrosingopine the weakest in the depleting effects on brain amines of rauwolfia alkaloids. After syrosingopine, brain dopamine (DA) was decreased to a smaller degree and with a shorter duration as compared with norepinephrine (NE) and serotonin (5-HT), whereas re... | Selective depleting effect of syrosingopine on brain catecholamine levels with relation to morphine analgesia in the rat. Reserpine was the most potent, rescinnamine the next and syrosingopine the weakest in the depleting effects on brain amines of rauwolfia alkaloids. After syrosingopine, brain dopamine (DA) was decre... | [
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PMID:6977 | Nuclear dna amounts in angiosperms. | The number of angiosperm species for which nuclear DNA amount estimates have been made has nearly trebled since the last collected lists of such values were published, and therefore, publication of a more comprehensive list is over due. This paper lists absolute nuclear DNA amounts for 753 angiosperm species. The dats ... | Nuclear dna amounts in angiosperms. The number of angiosperm species for which nuclear DNA amount estimates have been made has nearly trebled since the last collected lists of such values were published, and therefore, publication of a more comprehensive list is over due. This paper lists absolute nuclear DNA amounts f... | [
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PMID:6982 | Electrophysiology of mammalian gland cells. | The resting cell membrane potential varies from -40 to -70 mV according to type of gland cell and species. The RP depends mainly on the large transmembrane concentration gradient for K maintained by a pump mechanism extruding Na and accumulating K. Since the Na permeability (PNa) is much smaller than PK, the Na concent... | Electrophysiology of mammalian gland cells. The resting cell membrane potential varies from -40 to -70 mV according to type of gland cell and species. The RP depends mainly on the large transmembrane concentration gradient for K maintained by a pump mechanism extruding Na and accumulating K. Since the Na permeability (... | [
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PMID:6983 | Breast sensation before and after plastic surgery. | Patients undergoing various plastic surgical procedures on their breasts were studied before and after operations with respect to sensation from crude touch, light pressure, and pain. The more extensive the operation on the breast (the more skin and breast tissue removed) the greater the postoperative decrease in sensa... | Breast sensation before and after plastic surgery. Patients undergoing various plastic surgical procedures on their breasts were studied before and after operations with respect to sensation from crude touch, light pressure, and pain. The more extensive the operation on the breast (the more skin and breast tissue remov... | [
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PMID:6985 | Exposure in vivo of agoraphobics: contributions of diazepam, group exposure, and anxiety evocation. | Fifty-seven chronic agoraphobic outpatients were treated by 12 hours of exposure in vivo on four days over two weeks to check the effects of oral diazepam versus placebo during group exposure, group versus individual exposure, and high versus medium anxiety arousal during individual exposure. The controlled parallel de... | Exposure in vivo of agoraphobics: contributions of diazepam, group exposure, and anxiety evocation. Fifty-seven chronic agoraphobic outpatients were treated by 12 hours of exposure in vivo on four days over two weeks to check the effects of oral diazepam versus placebo during group exposure, group versus individual exp... | [
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PMID:6991 | The regulation of physiological changes during mammalian aging. | Much evidence suggests that intrinsic molecular or cellular aging mechanisms need not be invoked to explain most age-related cellular changes and pathologcical conditions. Analysis of a widely scattered literature indicates that hormones and neural factors regulate a great number of cellular aging phenomena of mammals.... | The regulation of physiological changes during mammalian aging. Much evidence suggests that intrinsic molecular or cellular aging mechanisms need not be invoked to explain most age-related cellular changes and pathologcical conditions. Analysis of a widely scattered literature indicates that hormones and neural factors... | [
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PMID:7001 | Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. | Reserpine (1 mg/kg) was administered to pregnant rats on days 12, 13 and 14 of gestation. Although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 days of postnatal age, both were elevated by 17 days and the elevations persisted into adulthood. The changes may res... | Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. Reserpine (1 mg/kg) was administered to pregnant rats on days 12, 13 and 14 of gestation. Although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 d... | [
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PMID:7002 | Comparison of triazolam and methyprylon as a hypnotic in insomniacs. | The hypnotic effect of a new triazolobenzodiazepine, triazolam (0.5 mg) and methyprylon was compared in 30 outpatient volunteers with insomnia using the preference technique. On the first night of the 2 night trial, triazolam or methyprylon was given on a double-blind basis and on the 2nd night the outpatients received... | Comparison of triazolam and methyprylon as a hypnotic in insomniacs. The hypnotic effect of a new triazolobenzodiazepine, triazolam (0.5 mg) and methyprylon was compared in 30 outpatient volunteers with insomnia using the preference technique. On the first night of the 2 night trial, triazolam or methyprylon was given ... | [
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PMID:7003 | The effect of butaclamol and of other neuroleptic agents on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. | The effects of the two enantiomers of butaclamol and of several neuroleptics on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity was investigated. The (+) but not the (-) enantiomer of butaclamol reverses the apomorphine-elicited enzyme inhibition. (+) Butaclamol is more potent than the... | The effect of butaclamol and of other neuroleptic agents on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. The effects of the two enantiomers of butaclamol and of several neuroleptics on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity was investigate... | [
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PMID:7005 | Subsynaptosomal distribution, inhibition, and characterization of the binding of (14C) 5-OH-indole-3-acetaldehyde to brain preparations. | The distribution of the monoamine oxidase (MAO) dependent binding of [14C] serotonin as well as of pre-formed [14C] 5-OH-indole-3-acetaldehyde to synaptic subfractions paralleled the gross distribution of MAO. The binding of [14C] serotonin and MAO activity in brain preparations was inhibited by CNS antidepressants (im... | Subsynaptosomal distribution, inhibition, and characterization of the binding of (14C) 5-OH-indole-3-acetaldehyde to brain preparations. The distribution of the monoamine oxidase (MAO) dependent binding of [14C] serotonin as well as of pre-formed [14C] 5-OH-indole-3-acetaldehyde to synaptic subfractions paralleled the ... | [
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PMID:7006 | Respiratory failure: correlation between encephalopathy, blood gases and blood ammonia. | In 59 patients with respiratory insufficiency due to chronic obstructive pulmonary disease (COPD) the relationship between the state of consciousness, the blood gases and blood ammonia were studied. Interindividually, a significant correlation was found between the encephalopathy and SaO2, PaCO2 or ammonia, and also be... | Respiratory failure: correlation between encephalopathy, blood gases and blood ammonia. In 59 patients with respiratory insufficiency due to chronic obstructive pulmonary disease (COPD) the relationship between the state of consciousness, the blood gases and blood ammonia were studied. Interindividually, a significant ... | [
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PMID:7007 | Effect of ascaris extract applied intravenously, on segment bronchus and the influence of ipsilateral vagus blockade. | Respiratory hypersensitivity and systemic effects after local application of Ascaris suum extract on the segmental bronchus and after its intravenous infusion are studied on four boxer dogs. Influence of ipsilateral vagus blockade on the respiratory hyperreactivity after intrabronchial application of ascaris was also i... | Effect of ascaris extract applied intravenously, on segment bronchus and the influence of ipsilateral vagus blockade. Respiratory hypersensitivity and systemic effects after local application of Ascaris suum extract on the segmental bronchus and after its intravenous infusion are studied on four boxer dogs. Influence o... | [
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PMID:7008 | A simple method for the determination of the thread-forming property of tracheobronchial secretions. | A method is described for determining the thread-forming property ('Spinnbarkeit') of tracheobronchial secretions. With this method it was observed that adrenergic compounds increase the length of the mucus threads by an average of 154% whereas mucolytic agents caused an average decrease of 63% in the length of the muc... | A simple method for the determination of the thread-forming property of tracheobronchial secretions. A method is described for determining the thread-forming property ('Spinnbarkeit') of tracheobronchial secretions. With this method it was observed that adrenergic compounds increase the length of the mucus threads by a... | [
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PMID:7009 | Changes in skeletal muscle cell pH during graded changes in PCO2. | Blood perfusing isolated dog gracilis muscles was equilibrated with CO2 tensions ranging from 30 to 120 mm Hg, resulting in venous P CO2 from 35 to 135 mm Hg. Extracellular pH values ranged from 6.96 to 7.41, and muscle cell pH, calculated from DMO distribution, ranged from 6.64 to 6.94. When intracellular pH was plott... | Changes in skeletal muscle cell pH during graded changes in PCO2. Blood perfusing isolated dog gracilis muscles was equilibrated with CO2 tensions ranging from 30 to 120 mm Hg, resulting in venous P CO2 from 35 to 135 mm Hg. Extracellular pH values ranged from 6.96 to 7.41, and muscle cell pH, calculated from DMO distr... | [
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PMID:7010 | Intracellular and extracellular acid-base changes in hemorrhagic shock. | Each of 21 dogs was bled until mean arterial blood pressure fell to 50 torr; this hemorrhagic shock state was then maintained for two hours. During hemorrhagic shock, the blood lactate concentration increased sixfold. The severe metabolic acidosis in arterial blood was partially compensated by a decreased PCO2 caused b... | Intracellular and extracellular acid-base changes in hemorrhagic shock. Each of 21 dogs was bled until mean arterial blood pressure fell to 50 torr; this hemorrhagic shock state was then maintained for two hours. During hemorrhagic shock, the blood lactate concentration increased sixfold. The severe metabolic acidosis ... | [
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PMID:7011 | Extracellular and intracellular pH with changes of temperature in the dogfish Scyliorhinus stellaris. | Larger Spotted Dogfish, Scyliorhinus stellaris, were exposed to varied ambient temperature (t) in order to determine the behavior of extracellular pH (pHe), Pco2 and bicarbonate concentration as well as intracellular pH (pHi) in three muscle types. pHe was found to vary with temperature slightly less than expected on t... | Extracellular and intracellular pH with changes of temperature in the dogfish Scyliorhinus stellaris. Larger Spotted Dogfish, Scyliorhinus stellaris, were exposed to varied ambient temperature (t) in order to determine the behavior of extracellular pH (pHe), Pco2 and bicarbonate concentration as well as intracellular p... | [
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PMID:7012 | Importance of changes in plasma HCO-3 on regulation of CSF HCO-3 in respiratory alkalosis. | In respiratory alkalosis the fall in CSF bicarbonate is in part due to increased CSF lactate. The rest of CSF HCO3 fall may be actively regulated or as more recent evidence suggests is dependent on plasma HCO3 fall. Therefore, the relationship between plasma and CSF HCO3 changes was studied during 4 hours of respirator... | Importance of changes in plasma HCO-3 on regulation of CSF HCO-3 in respiratory alkalosis. In respiratory alkalosis the fall in CSF bicarbonate is in part due to increased CSF lactate. The rest of CSF HCO3 fall may be actively regulated or as more recent evidence suggests is dependent on plasma HCO3 fall. Therefore, th... | [
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PMID:7016 | Cholinergic changes during conditioned suppression in rats. | Levels of acetylcholine were significantly elevated in the telencephalon and diencephalon + mesencephalon of rats killed by near-freezing during conditioned suppression of food-reinforced lever pressing, whereas levels of serotonin, dopamine, and norepinephrine were not altered. These neurochemical changes were not see... | Cholinergic changes during conditioned suppression in rats. Levels of acetylcholine were significantly elevated in the telencephalon and diencephalon + mesencephalon of rats killed by near-freezing during conditioned suppression of food-reinforced lever pressing, whereas levels of serotonin, dopamine, and norepinephrin... | [
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PMID:7014 | [Treatment of anxiety in Parkinson's disease with bromazepam]. | The Authors observe that anxiety is a rather frequent symptom in parkinsonian patients. The possible mechanisms are reviewed. In a double blind cross-over trial, a new antianxiety agent (Lexotan, Roche) was compared with Placebo, to delineate the therapeutic effect in anxious parkinsonian patients. A noteworthy activit... | [Treatment of anxiety in Parkinson's disease with bromazepam]. The Authors observe that anxiety is a rather frequent symptom in parkinsonian patients. The possible mechanisms are reviewed. In a double blind cross-over trial, a new antianxiety agent (Lexotan, Roche) was compared with Placebo, to delineate the therapeuti... | [
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PMID:7025 | Drug-induced handwriting changes: an empirical review. | Since handwriting is a highly complex, coordinated motor activity, handwrits of pharmacological agents. Its potential has been most evident in research involving therapeutic administrations of anti-psychotic an anti-Parkinsonian drugs, from which consistent and systematic handwriting changes have been observed. This r... | Drug-induced handwriting changes: an empirical review. Since handwriting is a highly complex, coordinated motor activity, handwrits of pharmacological agents. Its potential has been most evident in research involving therapeutic administrations of anti-psychotic an anti-Parkinsonian drugs, from which consistent and sy... | [
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PMID:7032 | Organic dyestuffs as catalysts for fuel cells. | Electrocatalysis in fuel cells requires as well substances capable of catalyzing the anodic oxidation of fuels as catalysts for the cathodic reduction of oxygen. Several dyestuffs that catalyze oxygen reduction are known, but up to now only one has been described as active in anodic reactions. All these dyestuffs are N... | Organic dyestuffs as catalysts for fuel cells. Electrocatalysis in fuel cells requires as well substances capable of catalyzing the anodic oxidation of fuels as catalysts for the cathodic reduction of oxygen. Several dyestuffs that catalyze oxygen reduction are known, but up to now only one has been described as active... | [
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PMID:7033 | Japanese encephalitis virus from pigs and mosquitoes in Jakarta, Indonesia. | Japanese encephalitis virus was isolated from 11 pools of Culex tritaeniorhynchus and a single pool of C. gelidus mosquitoes at a pig-raising area near Jakarta, West Java, Indonesia, during 1972-74. Ten sentinel pigs placed in the area all developed haemagglutination-inhibition antibodies against Japanese encephalitis ... | Japanese encephalitis virus from pigs and mosquitoes in Jakarta, Indonesia. Japanese encephalitis virus was isolated from 11 pools of Culex tritaeniorhynchus and a single pool of C. gelidus mosquitoes at a pig-raising area near Jakarta, West Java, Indonesia, during 1972-74. Ten sentinel pigs placed in the area all deve... | [
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PMID:7034 | Acute graft-versus-host reaction in mice. I. Cellular events. | Cellular events in the spleen during the development of acute GvH reaction in lethally irradiated recipients of allogeneic lymphocytes may be divided into 6 interrelated processes: (1) entering and lodging in the spleen of about 17% of inoculated cells which forms the compartment of potentially reactive cells; (2) tran... | Acute graft-versus-host reaction in mice. I. Cellular events. Cellular events in the spleen during the development of acute GvH reaction in lethally irradiated recipients of allogeneic lymphocytes may be divided into 6 interrelated processes: (1) entering and lodging in the spleen of about 17% of inoculated cells which... | [
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PMID:7035 | Avoidance of graft versus host reactions in cured W-anemic mice. | Graft-versus-host reactions of parental cells in F1 hybrids were studied with two unrelated inbred strains of mice that differed at the mouse histocompatibility locus. W-anemic F1 recipients were compared with lethally irradiated normal F1 recipients. Both sets of recipients were populated by marrow and spleen cell gra... | Avoidance of graft versus host reactions in cured W-anemic mice. Graft-versus-host reactions of parental cells in F1 hybrids were studied with two unrelated inbred strains of mice that differed at the mouse histocompatibility locus. W-anemic F1 recipients were compared with lethally irradiated normal F1 recipients. Bot... | [
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PMID:7040 | [Values of acid-base equilibrium in the blood of various species of domestic animals]. | By means of the Astrup equilibration method the values of the acid-base balance of the blood were determined in 104 cows, 99 horses, 100 pigs, 15 sheep, 20 goats, and in 101 dogs. The pH values of the blood, the partial pressure of CO2, the base excess, the base buffer, the standard bicarbonate, the actual bicarbonate,... | [Values of acid-base equilibrium in the blood of various species of domestic animals]. By means of the Astrup equilibration method the values of the acid-base balance of the blood were determined in 104 cows, 99 horses, 100 pigs, 15 sheep, 20 goats, and in 101 dogs. The pH values of the blood, the partial pressure of C... | [
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PMID:7043 | Species and phenobarbitone-induced differences in the kinetic constants of liver microsomal harmine O-demethylation. | 1. The apparent kinetic constants for the O-demethylation of harmine to harmol by 10 000 g supernatant fractions from livers of mice, rats, guinea-pigs, rabbits, cats and cows have been determined. The Km values were 10-39 muM and Vmax 0-25 and 1-65 nmol/mg protein/min. 2. Optimal conditions of incubation time and NADP... | Species and phenobarbitone-induced differences in the kinetic constants of liver microsomal harmine O-demethylation. 1. The apparent kinetic constants for the O-demethylation of harmine to harmol by 10 000 g supernatant fractions from livers of mice, rats, guinea-pigs, rabbits, cats and cows have been determined. The K... | [
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PMID:7056 | Severe urticaria caused by a moth Euproctis sp. (Lepidoptera: Lymantriidae). | The urticating hairs of a moth Euproctis sp., were found to be the cause of a severe urticarial and pruritic rash in an expatriate family. Such incidents are probably not uncommon in Papua New Guinea, and are best solved by destroying the food tree of the caterpillars where this is feasible. | Severe urticaria caused by a moth Euproctis sp. (Lepidoptera: Lymantriidae). The urticating hairs of a moth Euproctis sp., were found to be the cause of a severe urticarial and pruritic rash in an expatriate family. Such incidents are probably not uncommon in Papua New Guinea, and are best solved by destroying the food... | [
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PMID:7057 | [Transparency of analytical results found by different methods of electrophoresis studies on casein (author's transl)]. | The electrophoretic mobility of the major casein components has been studied on different carriers. Besides free electrophoresis and paper electrophoresis starch gel, polyacrylamide gel and cellulose acetate gel have compared. With urea buffer mixtures of neutral to alkaline pH a mobility scale on all gels was found co... | [Transparency of analytical results found by different methods of electrophoresis studies on casein (author's transl)]. The electrophoretic mobility of the major casein components has been studied on different carriers. Besides free electrophoresis and paper electrophoresis starch gel, polyacrylamide gel and cellulose ... | [
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PMID:7058 | [Behaviour of aflatoxin during production of processed cheese (author's transl)]. | The problem of aflatoxin determination in processed cheese can be solved by the destruction of the emulsion with 6 m urea solution; the detection limit is 0.1-0.05 ppb B1 respectively G1. Examination of 115 trade samples resulted in 2 positive processed cheese samples only. This result cannot be reffered to the destruc... | [Behaviour of aflatoxin during production of processed cheese (author's transl)]. The problem of aflatoxin determination in processed cheese can be solved by the destruction of the emulsion with 6 m urea solution; the detection limit is 0.1-0.05 ppb B1 respectively G1. Examination of 115 trade samples resulted in 2 pos... | [
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PMID:7059 | The nitrosation products of creatine and creatinine in model systems. | The formation of N-nitrososarcosine from creatine, creatinine-5-oxime and l-methylhydantoin-5-oxime from creatinine was investigated in model solutions under various conditions (temperature, pH, concentration of sodium nitrite). N-nitrososarcosine was formed from creatine only in strongly acidic medium and its concentr... | The nitrosation products of creatine and creatinine in model systems. The formation of N-nitrososarcosine from creatine, creatinine-5-oxime and l-methylhydantoin-5-oxime from creatinine was investigated in model solutions under various conditions (temperature, pH, concentration of sodium nitrite). N-nitrososarcosine wa... | [
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PMID:7060 | [Examinations to phenomenon of shock-lung (author's transl)]. | The pathogenesis of shock lung as well as the success of therapy in this condition was studied in 79 cases of extrathoracic trauma. The water-, hemoglobin-, and DNA contents of the lungs were measured in order to determine the extent of edema, the rate of perfusion, and proliferation. The cases were divided into two gr... | [Examinations to phenomenon of shock-lung (author's transl)]. The pathogenesis of shock lung as well as the success of therapy in this condition was studied in 79 cases of extrathoracic trauma. The water-, hemoglobin-, and DNA contents of the lungs were measured in order to determine the extent of edema, the rate of pe... | [
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PMID:7062 | [Bacteriological findings in materials from patients with nonspecific odontogenic infections]. | The results of bacteriological studies made between 1964 and 1971 by workers at the Varia Laboratory, Institute of Medical Microbiology on 767 patients treated at the Clinic of Gnathofacial Surgery, Department of Medicine, Friedrich Schiller University at Jena, are evaluated. The testees (x=275) were included in groups... | [Bacteriological findings in materials from patients with nonspecific odontogenic infections]. The results of bacteriological studies made between 1964 and 1971 by workers at the Varia Laboratory, Institute of Medical Microbiology on 767 patients treated at the Clinic of Gnathofacial Surgery, Department of Medicine, Fr... | [
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PMID:7090 | Alkaline phosphatase of Thiobacillus thioparus. Partial purification and properties of the enzyme. | Soluble alkaline phosphatase from Thiobacillus thioparus cells was purified about 230-fold. The enzyme had a mol. wt. of 50 000 daltons, optimum pH at 10.5, and was heat-resistant in the presence of diethanolamine. Polyacrylamide-gel electrophoresis demonstrated contamination of the preparation with inactive proteins a... | Alkaline phosphatase of Thiobacillus thioparus. Partial purification and properties of the enzyme. Soluble alkaline phosphatase from Thiobacillus thioparus cells was purified about 230-fold. The enzyme had a mol. wt. of 50 000 daltons, optimum pH at 10.5, and was heat-resistant in the presence of diethanolamine. Polyac... | [
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PMID:7091 | Purification and properties of L-asparaginase from Mycobacterium phlei. | 1. L-asparaginase from M. phlei was purified about 170-fold with an 11% yield. The purification procedure consisted of: fractionation with ammonium sulphate; adsorption of contaminating proteins on calcium phosphate gel; chromatography on Sephadex G-150 and DEAE-cellulose. The specific activity of the final preparation... | Purification and properties of L-asparaginase from Mycobacterium phlei. 1. L-asparaginase from M. phlei was purified about 170-fold with an 11% yield. The purification procedure consisted of: fractionation with ammonium sulphate; adsorption of contaminating proteins on calcium phosphate gel; chromatography on Sephadex ... | [
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PMID:7092 | The synthesis and properties of N6-substituted 2-amino-purine derivatives. | 1. The synthesis, ultraviolet absorption spectra, and behaviour in alkali of N6-methoxy-, N6-methyl, hydroxy-, and N6-hydroxy-2-aminopurines have been described 2. N6-Methoxy-2-aminopurine riboside 5'-pyrophosphate has been prepared and used for polymerization with polynucleotide phosphorylase. 3. The copolymer contain... | The synthesis and properties of N6-substituted 2-amino-purine derivatives. 1. The synthesis, ultraviolet absorption spectra, and behaviour in alkali of N6-methoxy-, N6-methyl, hydroxy-, and N6-hydroxy-2-aminopurines have been described 2. N6-Methoxy-2-aminopurine riboside 5'-pyrophosphate has been prepared and used for... | [
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PMID:7093 | Amnesic action of and skills related to driving after intravenous flunitrazepam. | Amnesic action, skills related to driving and the ability to discriminate the fusion of flickering light were measured double-blind in 29 healthy volunteers before and after three doses of intravenous flunitrazepam. Every subject experienced amnesia for the pinching of the abdomen after being injected with flunitrazepa... | Amnesic action of and skills related to driving after intravenous flunitrazepam. Amnesic action, skills related to driving and the ability to discriminate the fusion of flickering light were measured double-blind in 29 healthy volunteers before and after three doses of intravenous flunitrazepam. Every subject experienc... | [
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PMID:7094 | A comparison of the effects of the inhalation of 4% and 8% fluroxene in the pregnant primate. | A comparison was made of the effects of inhalation of 4% fluroxene (n = 5) and 8% fluroxene (n = 5) in pregnant monkeys. Measurements of maternal arterial blood pressure, heart rate, cardiac output, total peripheral resistance, uterine blood flow, fetal heart rate and arterial blood pressure, and maternal and fetal blo... | A comparison of the effects of the inhalation of 4% and 8% fluroxene in the pregnant primate. A comparison was made of the effects of inhalation of 4% fluroxene (n = 5) and 8% fluroxene (n = 5) in pregnant monkeys. Measurements of maternal arterial blood pressure, heart rate, cardiac output, total peripheral resistance... | [
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PMID:7095 | Reduction of psychotomimetic side effects of Ketalar (ketamine) by Rohypnol (flunitrazepam). A randomized, double-blind trial. | A double-blind controlled trial based on 140 women undergoing abortus provocatus was employed to study whether the frequency of side effects after administration of the anaesthetic Ketalar (ketamine) could be reduced by a con-current dose of Rohypnol (flunitrazepam). The control group was given ketamine alone. The dosa... | Reduction of psychotomimetic side effects of Ketalar (ketamine) by Rohypnol (flunitrazepam). A randomized, double-blind trial. A double-blind controlled trial based on 140 women undergoing abortus provocatus was employed to study whether the frequency of side effects after administration of the anaesthetic Ketalar (ket... | [
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PMID:7097 | The experiment on the protein exposed to acoustic wave in model of hair cells. | Why do animals have intense troubles mainly in the basal turns of their cochleae by exposure to sound and the ototoxity? I thought that the protein in cells had an important relation to this subject. So I performed this experiment. I made model of hair cells of silicon and poured three kinds of solutions of protein int... | The experiment on the protein exposed to acoustic wave in model of hair cells. Why do animals have intense troubles mainly in the basal turns of their cochleae by exposure to sound and the ototoxity? I thought that the protein in cells had an important relation to this subject. So I performed this experiment. I made mo... | [
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PMID:7100 | Effects of metoprolol in angina pectoris. A subacute study with exercise tests and a long-term tolerability study. | Eighteen patients with angina pectoris, who had previously participated in a cross-over study with 20 mg metoprolol t.i.d. and placebo, have been included in this study. During an introductory six-month open tolerability study, all patients were treated with 50 mg metoprolol t.i.d. and during a subsequent cross-over st... | Effects of metoprolol in angina pectoris. A subacute study with exercise tests and a long-term tolerability study. Eighteen patients with angina pectoris, who had previously participated in a cross-over study with 20 mg metoprolol t.i.d. and placebo, have been included in this study. During an introductory six-month op... | [
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PMID:7101 | Effect of sugars, hydrogen ion concentration and ammonium nitrate on the formation of citric acid by Aspergillus niger. | Aspergillus niger Mulder strain when grown on a synthetic medium containing urea as the sole source of nitrogen at pH 5.2, formed a mixture of citric and gluconic acids. On growing the organism at pH 2.0 the gluconic acid content was reduced but citric acid yield remained low. Addition of NH4NO3 to the medium lowered t... | Effect of sugars, hydrogen ion concentration and ammonium nitrate on the formation of citric acid by Aspergillus niger. Aspergillus niger Mulder strain when grown on a synthetic medium containing urea as the sole source of nitrogen at pH 5.2, formed a mixture of citric and gluconic acids. On growing the organism at pH ... | [
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PMID:7105 | Arylsulfatases A and B in metachromatic leukodystrophy and Maroteaux-Lamy syndrome: studies with 4-methylumelliferyl sulfate. | Metachromatic leukodystrophy and Maroteaux-Lamy syndrome can be diagnosed by assay of leukocyte or fibroblast arylsulfatase A and B activity with the fluorogenic substrate 4-methylumbelliferyl sulfate. The arylsulfatases are extracted into a 27000 x g supernatant by sonication in 0.9% sodium chloride and then separated... | Arylsulfatases A and B in metachromatic leukodystrophy and Maroteaux-Lamy syndrome: studies with 4-methylumelliferyl sulfate. Metachromatic leukodystrophy and Maroteaux-Lamy syndrome can be diagnosed by assay of leukocyte or fibroblast arylsulfatase A and B activity with the fluorogenic substrate 4-methylumbelliferyl s... | [
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PMID:7107 | Identification of Tay-Sachs by hexosaminidase analysis of urine and tear samples. | 1. Two readily obtainable biological fluids, i.e., urine and tears, were investigated as possible substitutes for serum and leukocytes for the detection of Tay-Sachs disease (TSD) heterozygotes based on Quantitative hexosaminidase A (Hex A) determinations. 2. Hexosaminidase isoenzyme patterns were determined, by means ... | Identification of Tay-Sachs by hexosaminidase analysis of urine and tear samples. 1. Two readily obtainable biological fluids, i.e., urine and tears, were investigated as possible substitutes for serum and leukocytes for the detection of Tay-Sachs disease (TSD) heterozygotes based on Quantitative hexosaminidase A (Hex ... | [
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PMID:7111 | [Contribution to the knowledge of Swiss piroplasmas]. | The authors identify 3 species of Babesia, which parasitize cattle in Switzerland (Babesia major, B. divergens and B. hovis). They also confirm the presence of B. canis in a dog in the proximity of Geneva. Finally, for the first time in Switzerland, they point out the presence of non-identified Babesia in various roden... | [Contribution to the knowledge of Swiss piroplasmas]. The authors identify 3 species of Babesia, which parasitize cattle in Switzerland (Babesia major, B. divergens and B. hovis). They also confirm the presence of B. canis in a dog in the proximity of Geneva. Finally, for the first time in Switzerland, they point out t... | [
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PMID:7112 | [Apropos of the asexual multiplication of the tetrathyridia larva of Mesocestoides corti Hoeppli, 1925 (Cestoda: cyclophyllidea). (Prelimary note )]. | In Tetrathyridia of Mesocestoides corti exist large basophilic cells which are often seen in various stages of mitosis. From their distribution in larvae and from their capacity to form the regeneration blastema after experimental amputation of 2 suckers, it is supposed that these cells are very important for regenerat... | [Apropos of the asexual multiplication of the tetrathyridia larva of Mesocestoides corti Hoeppli, 1925 (Cestoda: cyclophyllidea). (Prelimary note )]. In Tetrathyridia of Mesocestoides corti exist large basophilic cells which are often seen in various stages of mitosis. From their distribution in larvae and from their c... | [
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PMID:7113 | [The biological cycle of Caryophyllaeus brachycollis Janiszweska, 1953 (Cestoda carophyllaeidae) a parasite of Barbus meridionalis Risso, 1826 in the south of France]. | Caryophyllaeus brachycollis Janiszweska, 1953 has been found for the first time in France in Barbus meridionalis Risso, 1926. Experimentally, the procercoid develops in Tubifex sp. and never in Limnodrilus sp. The different possibilities of life cycle of C. brachycollis in Europe have been compared. | [The biological cycle of Caryophyllaeus brachycollis Janiszweska, 1953 (Cestoda carophyllaeidae) a parasite of Barbus meridionalis Risso, 1826 in the south of France]. Caryophyllaeus brachycollis Janiszweska, 1953 has been found for the first time in France in Barbus meridionalis Risso, 1926. Experimentally, the procer... | [
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PMID:7114 | [Rats and bilharziasis in Guadeloupe]. | The rats in Guadeloupe (Rattus rattus and Rattus norvegicus) may play a part in schistosomiasis in three ways: - by harbouring fertile S. mansoni, a fact which serves to increase the total population of the parasite and may eventually take part in the infestation of man; - by harbouring a great number of Ribeiroia mar... | [Rats and bilharziasis in Guadeloupe]. The rats in Guadeloupe (Rattus rattus and Rattus norvegicus) may play a part in schistosomiasis in three ways: - by harbouring fertile S. mansoni, a fact which serves to increase the total population of the parasite and may eventually take part in the infestation of man; - by har... | [
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PMID:7115 | [The chronobiology of the cercaria of Ribeiroia marini (Faust and Hoffman, 1934) parasite of Biomphalaria glabrata: effect of the photoperiod on the rhythm of emergence]. | Ribeiroir marini cercariage emerge from the snail-host during the night, according to a circadian rhythm. The photoperiod is the synchronizer of this rhythm. Inversion of the photoperiod is immediately followed by inversion of the periodicity of emergence. No cercaria emerge in continuous light conditions. This inhibit... | [The chronobiology of the cercaria of Ribeiroia marini (Faust and Hoffman, 1934) parasite of Biomphalaria glabrata: effect of the photoperiod on the rhythm of emergence]. Ribeiroir marini cercariage emerge from the snail-host during the night, according to a circadian rhythm. The photoperiod is the synchronizer of this... | [
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PMID:7116 | [Contribution to the study of Microphallidae Travassos 1920 (trematoda). XXXII. Microphallus breviatus n. sp., a species with an abbreviated evolutive cycle from a Mediterranean pond in the Languedoc]. | Contribution to the study of Microphallidae Travassos, 1920 (Trematoda). XXXII. - Microphallus breviatus n. sp., a short life-cycle species of a mediterranean pond of Languedoc. The whole larval life-cycle of M. breviatus takes place in one host, Hydrobia ventrosa (Montagu), Mollusc Hydrobiidae. Hepato-pancreatic sporo... | [Contribution to the study of Microphallidae Travassos 1920 (trematoda). XXXII. Microphallus breviatus n. sp., a species with an abbreviated evolutive cycle from a Mediterranean pond in the Languedoc]. Contribution to the study of Microphallidae Travassos, 1920 (Trematoda). XXXII. - Microphallus breviatus n. sp., a sho... | [
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PMID:7117 | [Evolutive cycle of Paratimonia gobii, Prevot and Bartoli 1967 (trematoda-monorchiidea)]. | The cycle of Paratimonia gobii PREVOT & BARTOLLI, 1967 (Trematoda-Monorchiidae), a parasite of Pomatoschistus microps (Teleostei gobiidae), has been discovered and carried out experimentally. The mollusc, first intermediary host, is Abra ovata (Lamellibranchiata, Scrobiculariidae). The gymnocephalous cercaria leav... | [Evolutive cycle of Paratimonia gobii, Prevot and Bartoli 1967 (trematoda-monorchiidea)]. The cycle of Paratimonia gobii PREVOT & BARTOLLI, 1967 (Trematoda-Monorchiidae), a parasite of Pomatoschistus microps (Teleostei gobiidae), has been discovered and carried out experimentally. The mollusc, first intermediary ho... | [
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PMID:7118 | [A new nematode (allantonematidae) parasite of Heliophilus (T diptera, syrphidae)]. | For the second time, the authors have found a new entomophagous nematode parasitic in Syrphidae. The first species, which was described as Syrphonematidae nov. fam., is living in the duct of various aphidophagous species of Syrphidae. This one has been found in the hemocoel of adults of Helophilus trivittatus Fabricius... | [A new nematode (allantonematidae) parasite of Heliophilus (T diptera, syrphidae)]. For the second time, the authors have found a new entomophagous nematode parasitic in Syrphidae. The first species, which was described as Syrphonematidae nov. fam., is living in the duct of various aphidophagous species of Syrphidae. T... | [
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PMID:7119 | [Vegetation analysis used for the detection of exophile tick populations in the south-east of France: the example Ixodes ricinus (Linne 1758) (acarina, ixodoidea)]. | The cross-linking relation between the evidence of outside living tick populations and specific vegetation units allows for efficiently using the vegetation maps, and more especially the medium scale maps. Ixodes ricinus is referred to here as an example. The limitations of this data derived from such maps are evaluate... | [Vegetation analysis used for the detection of exophile tick populations in the south-east of France: the example Ixodes ricinus (Linne 1758) (acarina, ixodoidea)]. The cross-linking relation between the evidence of outside living tick populations and specific vegetation units allows for efficiently using the vegetatio... | [
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PMID:7121 | [An abnormally formed Ctenophthalmus assimilis assimilis (siphonapteres hystrichosyllidae)]. | A female flea is described the body of which is abnormally formed and compressed. It is characterized by a split along its back, raised up abdominal segments and by a shortening of its head. These anomalies might be explained by longitudinal compression of the body during pupation. The possibility of a mutation is not ... | [An abnormally formed Ctenophthalmus assimilis assimilis (siphonapteres hystrichosyllidae)]. A female flea is described the body of which is abnormally formed and compressed. It is characterized by a split along its back, raised up abdominal segments and by a shortening of its head. These anomalies might be explained b... | [
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PMID:7122 | Advantages of x-ray microanalysis in the field of medical mycology. | A new apparatus, which combines an electron microprobe and a scanning electron microscope, has been used. This apparatus enabled to conduct a systematic elemental analysis of two species among Aspergillaceae. All elements in the periodic table whose atomic numbers lie between boron and uranium can be detected. | Advantages of x-ray microanalysis in the field of medical mycology. A new apparatus, which combines an electron microprobe and a scanning electron microscope, has been used. This apparatus enabled to conduct a systematic elemental analysis of two species among Aspergillaceae. All elements in the periodic table whose at... | [
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PMID:7123 | [Hepatic amebiasis in the Kilimanjaro region. Serodiagnosis on micro-specimens of dried blood and attempts at treatment with tinidazole (fasigyn)]. | Amoebic dysentery appears to be rare in the northeast of Tanzania. Hepatic amoebiasis, on the other hand, is apparently widespread since at least 200 cases are seen every year at the Kilimanjaro Christian Medical Centre. This incidence of cases enabled us to carry out trials on the spot with a new imidazole derivative,... | [Hepatic amebiasis in the Kilimanjaro region. Serodiagnosis on micro-specimens of dried blood and attempts at treatment with tinidazole (fasigyn)]. Amoebic dysentery appears to be rare in the northeast of Tanzania. Hepatic amoebiasis, on the other hand, is apparently widespread since at least 200 cases are seen every y... | [
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PMID:7124 | [Epidemic of autochthonous hepatic and intestinal amebiasis in a place near Grenoble]. | We had the opportunity of studying an epidemic of autochthonous amoebiasis occurring in the autumn of 1974 in a small town of 4000 inhabitants 30 km from Grenoble. Attention was originally attracted by the occurrence in this town of two cases of hepatic amoebiasis and one of intestinal amoebiasis identified by rectosco... | [Epidemic of autochthonous hepatic and intestinal amebiasis in a place near Grenoble]. We had the opportunity of studying an epidemic of autochthonous amoebiasis occurring in the autumn of 1974 in a small town of 4000 inhabitants 30 km from Grenoble. Attention was originally attracted by the occurrence in this town of ... | [
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PMID:7125 | [Leishmaniasis in south-eastern France- -ecology, epidemiology, prophylaxis]. | A study of the ecology, epidemiology and prophylaxis of Leishmaniasis in the southeast of France is reported; different methods of the survey are recorded. Between 1965 and 1975, 972 cases of canine Leishmaniasis and from 1968 to 1975 89 cases of visceral human Leishmaniasis and only 3 cases of oriental sore were obser... | [Leishmaniasis in south-eastern France- -ecology, epidemiology, prophylaxis]. A study of the ecology, epidemiology and prophylaxis of Leishmaniasis in the southeast of France is reported; different methods of the survey are recorded. Between 1965 and 1975, 972 cases of canine Leishmaniasis and from 1968 to 1975 89 case... | [
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PMID:7126 | [Presence of Angiostrongylus cantonensis at la Réunion]. | The eosinophilic meningitis due to Angiostrongylus cantonensis is well known on Madagascar and on Mauritius Island, but was never described on Reunion Island. Two cases have been lately oberved in Doctor Jay's department at Gabriel Martin's hospital. Local achatines were dissected and contained larvae which, when absor... | [Presence of Angiostrongylus cantonensis at la Réunion]. The eosinophilic meningitis due to Angiostrongylus cantonensis is well known on Madagascar and on Mauritius Island, but was never described on Reunion Island. Two cases have been lately oberved in Doctor Jay's department at Gabriel Martin's hospital. Local achati... | [
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PMID:7133 | Mucocutaneous lymph node syndrome with coronary artery aneurysm. | A white North American girl with clinical features of the mucocutaneous lymph node syndrome had a myocardial infarct and angiographic evidence of a coronary artery aneurysm and mitral regurgitation. The mucocutaneous lymph node syndrome has been extensively diagnosed in Japan in recent years. It appears to be a distinc... | Mucocutaneous lymph node syndrome with coronary artery aneurysm. A white North American girl with clinical features of the mucocutaneous lymph node syndrome had a myocardial infarct and angiographic evidence of a coronary artery aneurysm and mitral regurgitation. The mucocutaneous lymph node syndrome has been extensive... | [
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PMID:7134 | Mucocutaneous lymph node syndrome in the United States. | Sixteen patients with an unusual and distinct symptom complex were encountered during a four-year period. Principal features of this syndrome are (1) fever lasting more than seven days; (2) conjunctival injection; (3) changes in the mouth consisting of erythema of the oropharynx, "strawberry tongue", and erythema of th... | Mucocutaneous lymph node syndrome in the United States. Sixteen patients with an unusual and distinct symptom complex were encountered during a four-year period. Principal features of this syndrome are (1) fever lasting more than seven days; (2) conjunctival injection; (3) changes in the mouth consisting of erythema of... | [
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PMID:7135 | Inhibition of nocturnal acid secretion in duodenal ulcer patients by an H-2 histamine antagonist-cimetidine. A controlled double-blind investigation. | A new H-2-receptor antagonist, cimetidine, was tested as to its ability to suppress overnight gastric acid secretion in 8 male duodenal ulcer patients. In a double-blind controlled investigation, each volunteer was studied during four consecutive nights. In randomized order they received either 100, 200, or 300 mg of c... | Inhibition of nocturnal acid secretion in duodenal ulcer patients by an H-2 histamine antagonist-cimetidine. A controlled double-blind investigation. A new H-2-receptor antagonist, cimetidine, was tested as to its ability to suppress overnight gastric acid secretion in 8 male duodenal ulcer patients. In a double-blind ... | [
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PMID:7136 | Treatment of chronic radiation enteritis and colitis with salicylazosulfapyridine and systemic corticosteroids. A pilot study. | Four patients with severe chronic radiation enteritis and/or colitis were treated with anti-inflammatory drugs that are used conventionally in the treatment of idiopathic inflammatory bowel disease. Salicylazosulfapyridine (SASP) was used in the treatment of all four patients, while one patient received oral prednisone... | Treatment of chronic radiation enteritis and colitis with salicylazosulfapyridine and systemic corticosteroids. A pilot study. Four patients with severe chronic radiation enteritis and/or colitis were treated with anti-inflammatory drugs that are used conventionally in the treatment of idiopathic inflammatory bowel dis... | [
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PMID:7137 | Elevated serum gamma-glutamyl-transferase (transpeptidase) and histological liver damage in alcoholism. | In 66 alcoholic patients, serum gamma-glutamyl-transferase (transpeptidase) (GGTP) activity was studied in relationship to other biochemical liver function tests and histological liver damage. Elevated serum GGTP activity was the single most common biochemical abnormality (74%) and, when present was accompanied by hist... | Elevated serum gamma-glutamyl-transferase (transpeptidase) and histological liver damage in alcoholism. In 66 alcoholic patients, serum gamma-glutamyl-transferase (transpeptidase) (GGTP) activity was studied in relationship to other biochemical liver function tests and histological liver damage. Elevated serum GGTP act... | [
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PMID:7138 | Search for epizootic-like Venezuelan encephalitis virus at enzootic habitats in Guatemala during 1969-1971. | Seventy-four strains of Venezuelan encephalitis (VE) virus recovered from sentinel hamsters or mosquitoes at enzootic habitats in Guatemala in the two years following the 1969 epidemic-equine epizootic were examined for ability to produce small plaques in Vero African green monkey kidney cell cultures, like isolates ob... | Search for epizootic-like Venezuelan encephalitis virus at enzootic habitats in Guatemala during 1969-1971. Seventy-four strains of Venezuelan encephalitis (VE) virus recovered from sentinel hamsters or mosquitoes at enzootic habitats in Guatemala in the two years following the 1969 epidemic-equine epizootic were exami... | [
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PMID:7139 | Search for persistent epizootic Venezuelan encephalitis virus in Guatemala, El Salvador and Nicaragua during 1970-1975. | Evidence was sought during 1970-1975 of persistence of equine-virulent Venezuelan encephalitis (VE) virus in regions of Central America that were heavily involved in the epidemic-equine epizootic of 1969. (a) Four sentinel horses were exposed in an arid, upland region of the Atlantic drainage of Guatemala during August... | Search for persistent epizootic Venezuelan encephalitis virus in Guatemala, El Salvador and Nicaragua during 1970-1975. Evidence was sought during 1970-1975 of persistence of equine-virulent Venezuelan encephalitis (VE) virus in regions of Central America that were heavily involved in the epidemic-equine epizootic of 1... | [
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PMID:7140 | A decrease in cell-mediated immunity in uremia associated with an increase in activity of suppressor cells. | The graft-versus-host (GVH) reactivity of uremic and control spleen cells was studied by popliteal lymph node assay in the rat. The reaction evoked by cells from animals with severe uremia was conspicuously weaker than that evoked by control cells. The magnitude of the GVH reaction induced by control cells was directly... | A decrease in cell-mediated immunity in uremia associated with an increase in activity of suppressor cells. The graft-versus-host (GVH) reactivity of uremic and control spleen cells was studied by popliteal lymph node assay in the rat. The reaction evoked by cells from animals with severe uremia was conspicuously weake... | [
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PMID:7141 | Coronary vascular sympathetic beta-receptor innervation. | Recent studies indicate that coronary vessels have alpha- and beta-2-adrenergic receptors and that the alpha receptors are functionally innervated. We studied whether the beta-2-vasodilator receptors are functionally innervated, using a dog in situ modified Langendorff preparation with constant coronary perfusion press... | Coronary vascular sympathetic beta-receptor innervation. Recent studies indicate that coronary vessels have alpha- and beta-2-adrenergic receptors and that the alpha receptors are functionally innervated. We studied whether the beta-2-vasodilator receptors are functionally innervated, using a dog in situ modified Lange... | [
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PMID:7142 | Uric acid excretion by the pig kidney. | The handling of uric acid by the pig kidney has been investigated during continuous urate infusion in unrestrained, unanesthetized animals. Urate-to-inulin clearance rates in excess of 1 were found under all experimental conditions, demonstrating only net secretion by the pig kidney. The demonstration of a secretory ma... | Uric acid excretion by the pig kidney. The handling of uric acid by the pig kidney has been investigated during continuous urate infusion in unrestrained, unanesthetized animals. Urate-to-inulin clearance rates in excess of 1 were found under all experimental conditions, demonstrating only net secretion by the pig kidn... | [
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PMID:7143 | Heart rate and rhythm and intracranial pressure. | Cardiac slowing during elevated intracranial pressure (ICP) could be due to direct activation of central nervous system (CNS) centers or it may be secondary to baroreceptor reflexes activated by the associated pressor response. In five pentobarbital-anesthetized dogs when ICP was raised to 50 mmHg the heart rate decrea... | Heart rate and rhythm and intracranial pressure. Cardiac slowing during elevated intracranial pressure (ICP) could be due to direct activation of central nervous system (CNS) centers or it may be secondary to baroreceptor reflexes activated by the associated pressor response. In five pentobarbital-anesthetized dogs whe... | [
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PMID:7144 | Effects of hypoxia and Freon 12 on mechanics of cardiac contraction. | Data are presented which indicate that the mechanism of tension depression and subsequent recovery from dichlorodifluoromethane (Freon 12), an aerosol gas recently described as a potent cardiac depressant agent, differs from that of hypoxia. To analyze these differences, 22 rat papillary muscles, contracting isometrica... | Effects of hypoxia and Freon 12 on mechanics of cardiac contraction. Data are presented which indicate that the mechanism of tension depression and subsequent recovery from dichlorodifluoromethane (Freon 12), an aerosol gas recently described as a potent cardiac depressant agent, differs from that of hypoxia. To analyz... | [
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PMID:7146 | Management of interpersonal issues in systematic desensitization. | The authors use the management of typical clinical problems that arise during systematic desensitization as a model for the analysis and solution of problems associated with behavior therapy techniques. Three main problem areas are considered: initiation of the technique, therapist and patient difficulties, and therape... | Management of interpersonal issues in systematic desensitization. The authors use the management of typical clinical problems that arise during systematic desensitization as a model for the analysis and solution of problems associated with behavior therapy techniques. Three main problem areas are considered: initiation... | [
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PMID:7145 | Reduced high-energy phosphate levels in rat hearts. I. Effects of alloxan diabetes. | Significant alterations in heart carbohydrate and lipid metabolism are present 48 h after intravenous injection of alloxan (60 mg/kg) in rats. It has been suggested that uncoupling of oxidative phosphorylation occurs in the alloxanized rat heart in vivo, whereas normal oxidative metabolism has been demonstrated in allo... | Reduced high-energy phosphate levels in rat hearts. I. Effects of alloxan diabetes. Significant alterations in heart carbohydrate and lipid metabolism are present 48 h after intravenous injection of alloxan (60 mg/kg) in rats. It has been suggested that uncoupling of oxidative phosphorylation occurs in the alloxanized ... | [
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PMID:7148 | Arbovirus surveillance in six states during 1972. | A virus surveillance project was established and maintained during 1972 along 10 major river drainages in six states. Mosquitoes, biting flies, and blood specimens from sentinel equines were collected during 83 field trip visits to 141 arthropod collecting sites and 22 sentinel locations from April into December 1972. ... | Arbovirus surveillance in six states during 1972. A virus surveillance project was established and maintained during 1972 along 10 major river drainages in six states. Mosquitoes, biting flies, and blood specimens from sentinel equines were collected during 83 field trip visits to 141 arthropod collecting sites and 22 ... | [
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PMID:7149 | A note on the use of trypsinized human group O erythrocytes in arbovirus titrations. | Twenty-two different arbovirus antigens derived from five antigenic groups were examined for their ability to agglutinate normal and trypsinized human group O erythrocytes. Trypsinization rendered the cells susceptible to agglutination by 18 viruses,chiefly in the pH 5.85 to 6.2 range, yielding hemagglutinin titers com... | A note on the use of trypsinized human group O erythrocytes in arbovirus titrations. Twenty-two different arbovirus antigens derived from five antigenic groups were examined for their ability to agglutinate normal and trypsinized human group O erythrocytes. Trypsinization rendered the cells susceptible to agglutination... | [
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PMID:7150 | Respiratory effects of 'lissive" anaesthesia using gallamine. | 'Lissive anaesthesia', the administration of a small dose of a non-depolarising muscle relaxant to a patient breathing nitrous oxide, oxygen and an anaesthetic vapour, is a technique popularly employed for minor procedures. In this study, the effects of intravenous gallamine triethiodide (40 mg) on the blood-gas status... | Respiratory effects of 'lissive" anaesthesia using gallamine. 'Lissive anaesthesia', the administration of a small dose of a non-depolarising muscle relaxant to a patient breathing nitrous oxide, oxygen and an anaesthetic vapour, is a technique popularly employed for minor procedures. In this study, the effects of intr... | [
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PMID:7151 | Anaesthetic induction for Caesarean section with propanidid. | Propanidid was used for the induction of anaesthesia at Caesarean section in 50 healthy mothers. All parturients were considered to have normal placental function. Anaesthesia was maintained with nitrous oxide, oxygen, muscle relaxant and controlled ventilation. The patients were tilted laterally with a 15 degrees rubb... | Anaesthetic induction for Caesarean section with propanidid. Propanidid was used for the induction of anaesthesia at Caesarean section in 50 healthy mothers. All parturients were considered to have normal placental function. Anaesthesia was maintained with nitrous oxide, oxygen, muscle relaxant and controlled ventilati... | [
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PMID:7152 | The use of AH8165 for Caesarian section. | The use of AH8165, a new non-depolarising relaxant, for Caesarian section is reported. The rapidity of action and the absence of significant placental transfer of the drug were confirmed. AH8165 has a definite place in obstetric anaesthesia. | The use of AH8165 for Caesarian section. The use of AH8165, a new non-depolarising relaxant, for Caesarian section is reported. The rapidity of action and the absence of significant placental transfer of the drug were confirmed. AH8165 has a definite place in obstetric anaesthesia. | [
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PMID:7155 | Cerebral arterio-venous oxygen difference: a bedside test for cerebral death. | A bedside test is described which compares the patients cerebral arterio-venous oxygen difference with a predicted norm at various levels of arterial CO2 tension. In patients in coma depasse this difference is reduced and is unresponsive to variations in arterial carbon dioxide tension. The test also confirms lack of r... | Cerebral arterio-venous oxygen difference: a bedside test for cerebral death. A bedside test is described which compares the patients cerebral arterio-venous oxygen difference with a predicted norm at various levels of arterial CO2 tension. In patients in coma depasse this difference is reduced and is unresponsive to v... | [
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PMID:7156 | Flunitrazepam, a new benzodiazepine compound in general anaesthesia. Clinical and statistical considerations on the first thousand cases. | Flunitrazepam, a derivative of benzodiazepine was used for induction and maintenance of anaesthesia in 933 patients. The induction dose was from 1,786 to 2,053 mg. The total dose of 2-2.66 mg was sufficient for maintenance of hypnosis for about 2 hours. The undesirable side effects were very rare. The average time of h... | Flunitrazepam, a new benzodiazepine compound in general anaesthesia. Clinical and statistical considerations on the first thousand cases. Flunitrazepam, a derivative of benzodiazepine was used for induction and maintenance of anaesthesia in 933 patients. The induction dose was from 1,786 to 2,053 mg. The total dose of ... | [
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PMID:7162 | [Constant outflow anesthesia with the combination of alfatesine and fentanyl]. | In a previous work, the authors showed the value of administering Alfatesine, in interventions of long duration, at a constant rate by using an automatic syringe, and by combining it with destromoramide. In this new work the authors present an analagous study carried out in 47 subjects, in which dextromoramide was repl... | [Constant outflow anesthesia with the combination of alfatesine and fentanyl]. In a previous work, the authors showed the value of administering Alfatesine, in interventions of long duration, at a constant rate by using an automatic syringe, and by combining it with destromoramide. In this new work the authors present ... | [
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PMID:7163 | [Combination of R3365 (piritramide) and dehydrobenzperidol in animals. Respiratory effects and analgesia]. | 1 -- Respiratory depression has been studied in the no anaesthetized rabbit by analysis of the blood gases after an injection of Piritramide (R 3365) and dehydrobenzperidol. 2 -- The respiratory depression induced by Piritramide alone is less important after an injection of dehydrobenzperidol; the most interessant case... | [Combination of R3365 (piritramide) and dehydrobenzperidol in animals. Respiratory effects and analgesia]. 1 -- Respiratory depression has been studied in the no anaesthetized rabbit by analysis of the blood gases after an injection of Piritramide (R 3365) and dehydrobenzperidol. 2 -- The respiratory depression induced... | [
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PMID:7164 | [Variations in the activity of various curarizing substances as a function of the time of administration]. | This experiment was carried out upon the male-adulte-AF SPF-Wister Rat, anesthetized by the use of pentobarbital-Na at the only dosage of 40 mg/kg/IP and put under artificial ventilation. The animals were divided into two groups: Group I, "diurnal animals" curarized between 10 a.m and 4 p.m; Group 2, "nocturnal animals... | [Variations in the activity of various curarizing substances as a function of the time of administration]. This experiment was carried out upon the male-adulte-AF SPF-Wister Rat, anesthetized by the use of pentobarbital-Na at the only dosage of 40 mg/kg/IP and put under artificial ventilation. The animals were divided ... | [
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PMID:7165 | [2 cases of respiratory assistance with a membrane oxygenator]. | The authors report two cases of artificial ventilation with the assistance of a membrane oxygenator that was used, on the one hand, in the case of a 'malignant pneumopathy' and, on the other hand, in the case of a cardio-respiratory failure after a complete mending of a tetralogy of Fallot. Recovery was obtained in the... | [2 cases of respiratory assistance with a membrane oxygenator]. The authors report two cases of artificial ventilation with the assistance of a membrane oxygenator that was used, on the one hand, in the case of a 'malignant pneumopathy' and, on the other hand, in the case of a cardio-respiratory failure after a complet... | [
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PMID:7166 | [The setting up of a computer system for records of first entries at the emergency medical assistance service in Montpellier]. | The setting up of a computing device to exploit the files of first transports at the MONTPELLIER SAMU was started essentially in order to constitute a document both accurate and of easy access, able to memorize the physical and mental behaviour of a patient in a transient state. The results thus obtained include: 1 -- ... | [The setting up of a computer system for records of first entries at the emergency medical assistance service in Montpellier]. The setting up of a computing device to exploit the files of first transports at the MONTPELLIER SAMU was started essentially in order to constitute a document both accurate and of easy access,... | [
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PMID:7167 | [Tracheal stenosis after tracheotomy. Apropos of 12 cases in 227 observations]. | Out of 543 tracheotomized patients, 227 survived and 12 of them developed a tracheal stenosis syndrome (5,28 p. 100) including: 3 supra-ostial stenosis, 1 ostial and supra-ostial stenosis, 1 ostial stenosis, 3 intermediate stenosis and 4 distal stenosis. In two cases, the stenosis was found out during the removal of th... | [Tracheal stenosis after tracheotomy. Apropos of 12 cases in 227 observations]. Out of 543 tracheotomized patients, 227 survived and 12 of them developed a tracheal stenosis syndrome (5,28 p. 100) including: 3 supra-ostial stenosis, 1 ostial and supra-ostial stenosis, 1 ostial stenosis, 3 intermediate stenosis and 4 di... | [
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PMID:7171 | Sympathoadrenal Neurochemistry and early weaning of swine. | Three litters of pigs were weaned at 21 days of age, and 3 others were left with the sow. Pigs were killed at 21, 23, 28, or 39 days of age. Weaned pigs exhibited anxiety, gastrointestinal dysfunction, and decreased rate of body weight gain. Plasma glucose or liver glycogen concentrations were not decreased by weaning.... | Sympathoadrenal Neurochemistry and early weaning of swine. Three litters of pigs were weaned at 21 days of age, and 3 others were left with the sow. Pigs were killed at 21, 23, 28, or 39 days of age. Weaned pigs exhibited anxiety, gastrointestinal dysfunction, and decreased rate of body weight gain. Plasma glucose or l... | [
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PMID:7172 | The source of a minor alpha 1-antitrypsin in variant serum. | An antiserum produced against human alpha1-antitrypsin gave 2 precipitin lines by immunodiffusion when tested against sera displaying MZ or MS phenotypes. Only one line (major antigen) was seen with sera displaying M phenotype, but a second line (minor antigen) became evident when the serum was concentrated 5-fold. The... | The source of a minor alpha 1-antitrypsin in variant serum. An antiserum produced against human alpha1-antitrypsin gave 2 precipitin lines by immunodiffusion when tested against sera displaying MZ or MS phenotypes. Only one line (major antigen) was seen with sera displaying M phenotype, but a second line (minor antigen... | [
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PMID:7173 | Should fiberoptic bronchoscopy aspirates be cultured? | The reliability of fiberoptic bronchoscopy as a method to study the bacteriology of the lower respiratory tract was tested. The procedure used was suction aspiration through the inner channel after topical anesthesia with lidocaine. To detect contamination by oropharyngeal bacteria, the aspirates were cultured in patie... | Should fiberoptic bronchoscopy aspirates be cultured? The reliability of fiberoptic bronchoscopy as a method to study the bacteriology of the lower respiratory tract was tested. The procedure used was suction aspiration through the inner channel after topical anesthesia with lidocaine. To detect contamination by oropha... | [
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PMID:7174 | Spirometric comparison of carbuterol and isoproterenol aerosol therapy in bronchial asthma. A double blind, matched-pair study of 28 adults and a double blind crossover study of 18 children. | Two adrenergic aerosols were compared in a double blind, matched-pair study of 6 months' duration in 28 adult patients with chronic bronchial asthma, and in a double blind, crossover, short-term study in 18 children with severe asthma. In the adult study, one member of each pair was given either 150 mug of isoprotereno... | Spirometric comparison of carbuterol and isoproterenol aerosol therapy in bronchial asthma. A double blind, matched-pair study of 28 adults and a double blind crossover study of 18 children. Two adrenergic aerosols were compared in a double blind, matched-pair study of 6 months' duration in 28 adult patients with chron... | [
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PMID:7178 | Psychomotor skills during subacute treatment with thioridazine and bromazepam, and their combined effects with alcohol. | Twenty paid healthy students volunteered for a doubleblind cross-over trial on the effects of two weeks' treatment with placebo, thioridazine and bromazepam on psychomotor skills. The doses used were thioridazine 10 mg t.i.d. during the first week and 20 mg t.i.d. during the second week, or 6 mg of bromazepam t.i.d. du... | Psychomotor skills during subacute treatment with thioridazine and bromazepam, and their combined effects with alcohol. Twenty paid healthy students volunteered for a doubleblind cross-over trial on the effects of two weeks' treatment with placebo, thioridazine and bromazepam on psychomotor skills. The doses used were ... | [
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PMID:7179 | A new method using p-benzoquinone for coupling antigens and antibodies to marker substances. | A method using p-benzoquinone for coupling antigens and antibodies to enzymes and erythrocytes is described. The method involves the treatment of proteins (or polysaccharides) at pH 6 or 7 with an excess of p-benzoquinone. After removal of the unreacted reagent by gel filtration, the "activated" proteins were coupled a... | A new method using p-benzoquinone for coupling antigens and antibodies to marker substances. A method using p-benzoquinone for coupling antigens and antibodies to enzymes and erythrocytes is described. The method involves the treatment of proteins (or polysaccharides) at pH 6 or 7 with an excess of p-benzoquinone. Afte... | [
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PMID:7187 | [Ionization of the acid-base groups of polyene antibiotics in aqueous solutions]. | The acid-base characteristics of polyenic antibiotics, such as nystatin, mycoheptin and levorin in aqueous solutions were studied. A special procedure provided the use of potentiometric titration for investigation of ionization of the groups of vater-insoluble substances. The ionization constants of the carboxylic and ... | [Ionization of the acid-base groups of polyene antibiotics in aqueous solutions]. The acid-base characteristics of polyenic antibiotics, such as nystatin, mycoheptin and levorin in aqueous solutions were studied. A special procedure provided the use of potentiometric titration for investigation of ionization of the gro... | [
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PMID:7188 | Mechanism of action of miconazole: labilization of rat liver lysosomes in vitro by miconazole. | Miconazole, a potent antifungal agent, labilizes rat liver lysosomes. Its labilizing effect is followed by measuring the release of lysosomal hydrolases, namely, acid phosphatase, beta-glucuronidase, and arylsulfatase A. The effect of miconazole is concentration dependent in the range of 10(-5) to 1.2 x 10(-4) M. Howev... | Mechanism of action of miconazole: labilization of rat liver lysosomes in vitro by miconazole. Miconazole, a potent antifungal agent, labilizes rat liver lysosomes. Its labilizing effect is followed by measuring the release of lysosomal hydrolases, namely, acid phosphatase, beta-glucuronidase, and arylsulfatase A. The ... | [
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PMID:7189 | In vitro activity of josamycin against aerobic gram-positive cocci and anaerobes. | Josamycin, a new macrolide antibiotic, was compared with ampicillin, erythromycin, and clindamycin in vitro against 25 isolates each of pneumococci, enterococci, Staphylococcus aureus, S. epidermidis, and nonenterococcal hemolytic streptococci and against 25 anaerobes including 10 Bacteroides fragilis. Minimal inhibito... | In vitro activity of josamycin against aerobic gram-positive cocci and anaerobes. Josamycin, a new macrolide antibiotic, was compared with ampicillin, erythromycin, and clindamycin in vitro against 25 isolates each of pneumococci, enterococci, Staphylococcus aureus, S. epidermidis, and nonenterococcal hemolytic strepto... | [
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PMID:7190 | Observations on brilliant green agar with H2S indicator. | Several formulations of brilliant green agar with an added H2S indicator were evaluated. Results were optimum with variations of a basic formula consisting of 40 g of tryptic soy agar (Difco), 8 g of lactose, 8 g of sucrose, 80 mg of phenol red, 1 g of sulfanilamide, 1.5 g of ferric ammonium citrate, 5 g of sodium thio... | Observations on brilliant green agar with H2S indicator. Several formulations of brilliant green agar with an added H2S indicator were evaluated. Results were optimum with variations of a basic formula consisting of 40 g of tryptic soy agar (Difco), 8 g of lactose, 8 g of sucrose, 80 mg of phenol red, 1 g of sulfanilam... | [
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0... |
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