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PMID:9902 | Effects of added germination agents on loss of optical density in electron-irradiated spores. | Spores of Bacillus megaterium ATCC 14581, subjected to partial-cell iradiation, were exposed to either lysozyme, H2O2, or glucose in an attempt to reduce or eliminate the nonmonotonic behavior in curves of percentage of germination versus energy, obtained when such spores were resuspended in phosphate buffer alone. Exc... | Effects of added germination agents on loss of optical density in electron-irradiated spores. Spores of Bacillus megaterium ATCC 14581, subjected to partial-cell iradiation, were exposed to either lysozyme, H2O2, or glucose in an attempt to reduce or eliminate the nonmonotonic behavior in curves of percentage of germin... | [
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PMID:9913 | The accumulation and loss of dieldrin and endrin in the eastern oyster. | Oysters demonstrated an ability to significantly concentrate dieldrin and endrin. Concentration ratios obtained after 168-hr exposures to endrin were 1670 at 0.1 mug/L and 2780 at 50 mug/L. Dieldrin was concentrated to higher levels. Exposure to 14C-labelled dieldrin at 0.5 mug/L produced whole body concentrations 2880... | The accumulation and loss of dieldrin and endrin in the eastern oyster. Oysters demonstrated an ability to significantly concentrate dieldrin and endrin. Concentration ratios obtained after 168-hr exposures to endrin were 1670 at 0.1 mug/L and 2780 at 50 mug/L. Dieldrin was concentrated to higher levels. Exposure to 14... | [
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PMID:9914 | Fundoplication for reflux esophagitis: misadventures with the operation of choice. | Fundoplication, whether performed by thoracic or abdominal approach, is a sound method for control of reflux esophagitis. A series of 312 operations have been reviewed to assess the frequency of complications and the methods by which these can be prevented or treated effectively. Each source of an untoward outcome is e... | Fundoplication for reflux esophagitis: misadventures with the operation of choice. Fundoplication, whether performed by thoracic or abdominal approach, is a sound method for control of reflux esophagitis. A series of 312 operations have been reviewed to assess the frequency of complications and the methods by which the... | [
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PMID:9916 | Gastroesophageal reflux in esophageal scleroderma: diagnosis and implications. | Fifty-three patients with scleroderma were evaluated by history, barium swallow, and esophageal function tests. The most common esophageal symptoms were heartburn and dysphagia. Abnormal motility was seen radiologically in 43 patients, gastroesophageal reflux in only 9. Esophageal function tests demonstrated: (1) abnor... | Gastroesophageal reflux in esophageal scleroderma: diagnosis and implications. Fifty-three patients with scleroderma were evaluated by history, barium swallow, and esophageal function tests. The most common esophageal symptoms were heartburn and dysphagia. Abnormal motility was seen radiologically in 43 patients, gastr... | [
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PMID:9917 | Giant cell arteritis with visceral angiitis. | We describe a case in which giant cell arteritis coexisted with microscopic polyarteritis nodosa and focal-local glomerulonephritis. We also review previous cases of renal abnormalities in giant cell arteritis. We believe that this association of inflammatory renal disease and giant cell arteritis has not been document... | Giant cell arteritis with visceral angiitis. We describe a case in which giant cell arteritis coexisted with microscopic polyarteritis nodosa and focal-local glomerulonephritis. We also review previous cases of renal abnormalities in giant cell arteritis. We believe that this association of inflammatory renal disease a... | [
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PMID:9918 | [Experimental electric and biochemical data on ventricular fibrillation due to ischemia]. | The author presents the results of prolonged research into ventricular fibrillation during myocardial ischaemia, both from the electrocardiographic and biochemical standpoints. - He emphasises the successive tonic and atonic features of VF due to ischaemia, and the difference between the fibrillation in an ischaemic ar... | [Experimental electric and biochemical data on ventricular fibrillation due to ischemia]. The author presents the results of prolonged research into ventricular fibrillation during myocardial ischaemia, both from the electrocardiographic and biochemical standpoints. - He emphasises the successive tonic and atonic featu... | [
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PMID:9919 | Predicting the outcome of psychotherapy for schizophrenics. Relative contributions of patient, therapist, and treatment characteristics. | This study was designed to assess the relative prognostic importance of patient factors, therapist characterists, and treatment mode. The sample was 100 schizophrenic outpatients referred to a community mental health center following psychiatric hospitalization. Patients were randomly assigned to either group (N=50) or... | Predicting the outcome of psychotherapy for schizophrenics. Relative contributions of patient, therapist, and treatment characteristics. This study was designed to assess the relative prognostic importance of patient factors, therapist characterists, and treatment mode. The sample was 100 schizophrenic outpatients refe... | [
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PMID:9920 | Different behaviour of thymus in hosts bearing skin homografts or ehrlich ascites carcinoma. | Thymus behaviour in A2G male mice transplanted with skin homografts or Ehrlich ascites carcinoma was followed for a period of 28 days. In comparison with control mice of the same strain in which only a slowly physiological involution of the thymus was observed, a marked, irreversible involution was seen in the tumour-b... | Different behaviour of thymus in hosts bearing skin homografts or ehrlich ascites carcinoma. Thymus behaviour in A2G male mice transplanted with skin homografts or Ehrlich ascites carcinoma was followed for a period of 28 days. In comparison with control mice of the same strain in which only a slowly physiological invo... | [
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PMID:9921 | Extracorporeal membrane oxygenation during bronchopulmonary lavage. | Extracorporeal membrane oxygenation (ECMO) in a venoarterial perfusion circuit was used to provide support of gas exchange during bronchopulmonary lavage in a 32-year-old man with pulmonary alveolar proteinosis and severe arterial hypoxemia. Prior to the lavage, Pao2 during mechanical ventilation with 100% oxygen and p... | Extracorporeal membrane oxygenation during bronchopulmonary lavage. Extracorporeal membrane oxygenation (ECMO) in a venoarterial perfusion circuit was used to provide support of gas exchange during bronchopulmonary lavage in a 32-year-old man with pulmonary alveolar proteinosis and severe arterial hypoxemia. Prior to t... | [
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PMID:9922 | [On the toxicology of carbromal. I. Estimation of carbromal and its hypnotically active metabolites in rats and humans (author's transl)]. | To analyze the toxic effects of carbromal it was necessary to have information on the concentrations of carbromal and of its metabolites in the organism. This information can be obtained by a simple method based on gaschromatography that allows rapid, specific, sensitive and quantitative estimation of carbromal and of ... | [On the toxicology of carbromal. I. Estimation of carbromal and its hypnotically active metabolites in rats and humans (author's transl)]. To analyze the toxic effects of carbromal it was necessary to have information on the concentrations of carbromal and of its metabolites in the organism. This information can be obt... | [
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PMID:9923 | Late-onset acid maltase deficiency. Detection of patients and heterozygotes by urinary enzyme assay. | Daily urinary excretion of acid maltase (12.78 +/- 2.10 units/24 hr/mg of creatinine, in 11 normal adults) was significantly decreased in ten patients with late-onset acid maltase deficiency (1.33 +/- 0.16 units/24 hr; P less than .001) and 11 heterozygotes (3.27 +/- 0.62 units/24 hr; P less than .001). Maximal inhibit... | Late-onset acid maltase deficiency. Detection of patients and heterozygotes by urinary enzyme assay. Daily urinary excretion of acid maltase (12.78 +/- 2.10 units/24 hr/mg of creatinine, in 11 normal adults) was significantly decreased in ten patients with late-onset acid maltase deficiency (1.33 +/- 0.16 units/24 hr; ... | [
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PMID:9925 | Aspects of the use of lithium for the non-psychiatrist. | Lithium carbonate is commonly used in psychiatry, particularly in the management of the manic-depressive syndrome. It is also being increasingly tried in a variety of physical disorders. This essentially practical article summarizes important non-psychiatric aspects of the use of the drug, including its less common act... | Aspects of the use of lithium for the non-psychiatrist. Lithium carbonate is commonly used in psychiatry, particularly in the management of the manic-depressive syndrome. It is also being increasingly tried in a variety of physical disorders. This essentially practical article summarizes important non-psychiatric aspec... | [
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PMID:9926 | Homosexuality treated adventitiously in a stuttering therapy program: a case report presenting a heterophobic orientation. | The heterophobic orientation toward treatment of homosexuality is discussed. A case report is presented where homosexuality apparently "spontaneously remitted" and heterosexuality was instated while the patient underwent treatment for stuttering. The change in sexual orientation is interpreted as possibly adventitiousl... | Homosexuality treated adventitiously in a stuttering therapy program: a case report presenting a heterophobic orientation. The heterophobic orientation toward treatment of homosexuality is discussed. A case report is presented where homosexuality apparently "spontaneously remitted" and heterosexuality was instated whil... | [
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PMID:9930 | [Alterations of cat papillary muscle mechanics induced by changes of preload under variation of physical and chemical parameters (author's transl)]. | A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium. ... | [Alterations of cat papillary muscle mechanics induced by changes of preload under variation of physical and chemical parameters (author's transl)]. A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The op... | [
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PMID:9940 | Facultative anaerobiosis in molluscs. | The glycolytic fermentation of molluscs is rather complex. Multiple end products accumulate (lactate, alanine, octopine, succinate, propionate, acetate and CO2), which are partly formed in the cytoplasm and partly in the mitochondrion. Various schemes have been presented to account for these end products as well as for... | Facultative anaerobiosis in molluscs. The glycolytic fermentation of molluscs is rather complex. Multiple end products accumulate (lactate, alanine, octopine, succinate, propionate, acetate and CO2), which are partly formed in the cytoplasm and partly in the mitochondrion. Various schemes have been presented to account... | [
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PMID:9941 | Adaptations of enzymes for regulation of catalytic function. | 1. Enzymes must not only be extremely effective catalysts, but must also be the operating components of very sensitive and sophisticated regulatory systems. Appropriate evolutionary adjustment of the properties of different enzymes causes the sites that bind typical metabolic intermediates to be only partially saturate... | Adaptations of enzymes for regulation of catalytic function. 1. Enzymes must not only be extremely effective catalysts, but must also be the operating components of very sensitive and sophisticated regulatory systems. Appropriate evolutionary adjustment of the properties of different enzymes causes the sites that bind ... | [
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PMID:9948 | Early changes in the arterial wall of chickens fed a cholesterol diet. | A total of 160 1-2 day old chickens were fed a 2% cholesterol diet for a period of 8 to 42 days and compared with an equal number of controls. Aortas were analyzed for various indexes of reactivity of connective tissue, cholesterol content and scanning electron microscopy (SEM) characteristics of the endothelial lining... | Early changes in the arterial wall of chickens fed a cholesterol diet. A total of 160 1-2 day old chickens were fed a 2% cholesterol diet for a period of 8 to 42 days and compared with an equal number of controls. Aortas were analyzed for various indexes of reactivity of connective tissue, cholesterol content and scann... | [
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PMID:9950 | Isoprenaline antagonism of cardioselective beta-adrenergic receptor blocking agents on human and rat adipocytes. | 1. The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A good correlation was found between the potencies on adipocytes of the two species but not between our results and l... | Isoprenaline antagonism of cardioselective beta-adrenergic receptor blocking agents on human and rat adipocytes. 1. The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A go... | [
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PMID:9952 | Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. | Cimetidine, a new H2-receptor antagonist, was safely administered to eighteen healthy man by the intravenous, intraduodenal or oral route. 2 When gastric secretion was maximally stimulated by either histamine or pentagastrin, the simultaneous administration of cimetidine produced marked inhibition of both acid and peps... | Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. Cimetidine, a new H2-receptor antagonist, was safely administered to eighteen healthy man by the intravenous, intraduodenal or oral route. 2 When gastric secretion was maximally stimulated by either histamine or pentagastr... | [
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PMID:9953 | Inhibition of gastric emptying and drug absorption by narcotic analgesics. | The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorp... | Inhibition of gastric emptying and drug absorption by narcotic analgesics. The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and ... | [
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PMID:9954 | The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function. | Two identical studies, one comparing the effect of single doses of a new beta-adrenoceptor blocker, atenolol (Tenormin) (50 mg and 100 mg) and placebo, and the other comparing the effect of single doses of methyldopa (250 mg and 500 mg) and placebo, in healthy volunteers, were carried out. 2 In both studies the effect ... | The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function. Two identical studies, one comparing the effect of single doses of a new beta-adrenoceptor blocker, atenolol (Tenormin) (50 mg and 100 mg) and placebo, and the other comparing the effect of single doses of methyldopa (250 mg ... | [
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PMID:9963 | Effect of N-desmethyldiazepam (nordiazepam) and a precursor, potassium clorazepate, on sleep in man. | 1 The effect of N-desmethyldiazepam (nordiazepam, 5 and 10 mg) and potassium clorazepate (15 mg, a precursor of nordiazepam) on sleep was studied in six healthy adult males. Electroencephalography (EEG) was used for sleep measures, and analogue scales were used for subjective assessments of well-being and sleep quality... | Effect of N-desmethyldiazepam (nordiazepam) and a precursor, potassium clorazepate, on sleep in man. 1 The effect of N-desmethyldiazepam (nordiazepam, 5 and 10 mg) and potassium clorazepate (15 mg, a precursor of nordiazepam) on sleep was studied in six healthy adult males. Electroencephalography (EEG) was used for sle... | [
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PMID:9964 | Assessment of drugs in schizophrenia. Basic trial design. | Clinical trials with major tranquilizers must take into account the clinical features of patients with schizophrenia and pharmacokinetic and pharmacodynamic properties of the drug. The objectives of the trial must be carefully defined so that appropriate selection criteria for patients, rating instruments and dosage sc... | Assessment of drugs in schizophrenia. Basic trial design. Clinical trials with major tranquilizers must take into account the clinical features of patients with schizophrenia and pharmacokinetic and pharmacodynamic properties of the drug. The objectives of the trial must be carefully defined so that appropriate selecti... | [
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PMID:9965 | Assessment of drugs in schizophrenia. Asessment of drug-induced extrapyramidal reactions and of drugs given for their control. | I have tried to bring out some of the important methodological problems found in examining the effectiveness of drugs used in the control of druginduced parkinsonism by referring mainly to studies in which I have taken part. I hope I have shown that the whole topic is far less well understood than is often assumed. The... | Assessment of drugs in schizophrenia. Asessment of drug-induced extrapyramidal reactions and of drugs given for their control. I have tried to bring out some of the important methodological problems found in examining the effectiveness of drugs used in the control of druginduced parkinsonism by referring mainly to stud... | [
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PMID:9967 | Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam. | Psychomotor skills and visual functions related to driving were measured double-blind cross-over in ten healthy volunteers before, and 1,3,5 and 7 h after a single oral administration of diazepam (10mg), medazepam (15 mg) or lorazepam (2.5 mg). The late effects of lorazepam were tested in seven other subjects 12 and 24... | Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam. Psychomotor skills and visual functions related to driving were measured double-blind cross-over in ten healthy volunteers before, and 1,3,5 and 7 h after a single oral administration of diazepam (10mg... | [
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PMID:9968 | Assessment of alpha- and beta-adrenoceptor blocking actions of labetalol. | Isoprenaline dose-response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta-adrenoceptor sites. Phenylephrine dose-response curves using increases in systolic pressure before and after labetalol are suggestive of competitive antagonism at alpha-adrenoce... | Assessment of alpha- and beta-adrenoceptor blocking actions of labetalol. Isoprenaline dose-response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta-adrenoceptor sites. Phenylephrine dose-response curves using increases in systolic pressure before and ... | [
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PMID:9969 | The sensitivity of a malignant cell line to hyperthermia (42 degrees C) at low intracellular pH. | The postulate that low intracellular pH acts as a preconditioner for the destructuve effects of hyperthermia (42 degrees C) was examined, using a heat-sensitive line of malignant cells derived from rat mammary gland (SDB). Intracellular pH (pHi) was measured indirectly, from the distribution of the weak, non-metaboliz... | The sensitivity of a malignant cell line to hyperthermia (42 degrees C) at low intracellular pH. The postulate that low intracellular pH acts as a preconditioner for the destructuve effects of hyperthermia (42 degrees C) was examined, using a heat-sensitive line of malignant cells derived from rat mammary gland (SDB).... | [
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PMID:9970 | A comparison of the pupilloconstrictor effect of pilocarpine solution administered to the conjunctival sac as a single drop or as a continuous infusion in normal subjects. | Pilocarpine was administered into the conjunctival sac of normal volunteers by single-drop administration or by continuous infusion of a solution to the inner canthus by means of a fine Silastic tube. Using pupilloconstriction as a measure of response it was shown that infusion with a 0-01 per cent solution of pilocarp... | A comparison of the pupilloconstrictor effect of pilocarpine solution administered to the conjunctival sac as a single drop or as a continuous infusion in normal subjects. Pilocarpine was administered into the conjunctival sac of normal volunteers by single-drop administration or by continuous infusion of a solution to... | [
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PMID:9971 | Ribose recognition by ribonuclease T1: difference spectral binding studies with guanosine and deoxyguanosine. | The binding of ribonuclease T1 with guanosine (Guo) and deoxyguanosine (dGuo) was studied in experiments employing ultraviolet difference spectroscopy in the pH range 3-9 at 0.2 M ionic strength and 25 degrees C. Similar experiments were also conducted with psi-carboxymethyl-glutamate-58 ribonuclease T1 at pH 5.0. At m... | Ribose recognition by ribonuclease T1: difference spectral binding studies with guanosine and deoxyguanosine. The binding of ribonuclease T1 with guanosine (Guo) and deoxyguanosine (dGuo) was studied in experiments employing ultraviolet difference spectroscopy in the pH range 3-9 at 0.2 M ionic strength and 25 degrees ... | [
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PMID:9972 | Bovine brain purine-nucleoside phosphorylase purification, characterization, and catalytic mechanism. | Bovine brain purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) was purified to homogeneity at a specific activity of 78 mumol min-1 mg of protein-1. A molecular weight of 78 000-80 000 was calculated for the native enzyme by fel filtration on Sephadex. Gel electrophoresis... | Bovine brain purine-nucleoside phosphorylase purification, characterization, and catalytic mechanism. Bovine brain purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) was purified to homogeneity at a specific activity of 78 mumol min-1 mg of protein-1. A molecular weight of... | [
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PMID:9973 | Mung bean nuclease I. Physical, chemical, and catalytic properties. | A simplified purification procedure for mung bean nuclease has been developed yielding a stable enzyme that is homogeneous in regards to shape and size. The nuclease is a glycoprotein consisting of 29% carbohydrate by weight. It has a molecular weight of 39 000 as determined by polyacrylamide gel electrophoresis in the... | Mung bean nuclease I. Physical, chemical, and catalytic properties. A simplified purification procedure for mung bean nuclease has been developed yielding a stable enzyme that is homogeneous in regards to shape and size. The nuclease is a glycoprotein consisting of 29% carbohydrate by weight. It has a molecular weight ... | [
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PMID:9974 | Mung bean nuclease I. Terminally directed hydrolysis of native DNA. | Under conditions which favor the duplex structure of DNA, mung bean nuclease catalyzes a limited number of double-strand cleavages (probably less than 50) in the interior of native T7 DNA. However, under conditions which are not as favorable to a tight helical structure, the large duplex polymers previously produced ar... | Mung bean nuclease I. Terminally directed hydrolysis of native DNA. Under conditions which favor the duplex structure of DNA, mung bean nuclease catalyzes a limited number of double-strand cleavages (probably less than 50) in the interior of native T7 DNA. However, under conditions which are not as favorable to a tight... | [
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PMID:9975 | Effects of iodination of tyrosyl residues on the binding and action of glucagon at its receptor. | The binding and action of glucagon at its receptor in hepatic plasma membranes have been compared, as a function of pH, with that of glucagon containing iodotyrosyl residues. Iodinated glucagon, at pH 7.0 and below, binds to the receptor and activates adenylate cyclase with an affinity about threefold higher than that ... | Effects of iodination of tyrosyl residues on the binding and action of glucagon at its receptor. The binding and action of glucagon at its receptor in hepatic plasma membranes have been compared, as a function of pH, with that of glucagon containing iodotyrosyl residues. Iodinated glucagon, at pH 7.0 and below, binds t... | [
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PMID:9976 | Steady state kinetic analysis of the mechanism of guanosine triphosphate hydrolysis catalyzed by Escherichia coli elongation factor G and the ribosome. | The mechanism of guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor G and the ribosome in the absence of other participants in protein synthesis was examined by steady-state kinetic analysis. Optimal hydrolytic conditions were determined to be approximately pH 8.0, 20 mM Mg2+, and 80 mM NH4+. Kineti... | Steady state kinetic analysis of the mechanism of guanosine triphosphate hydrolysis catalyzed by Escherichia coli elongation factor G and the ribosome. The mechanism of guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor G and the ribosome in the absence of other participants in protein synthesis was... | [
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PMID:9977 | Nuclear magnetic resonance determination of intramolecular distances in bovine pancreatic trypsin inhibitor using nitrotyrosine chelation of lanthanides. | Nitration of tyrosine has been investigated as a means for chemically introducing lanthanide chelating sites at known positions in proteins. The low-field portions of the 250-MHZ and 270-MHZ 1H nuclear magnetic resonance spectra of native and chemically modified bovine pancreatic trypsin inhibitor have been studied in ... | Nuclear magnetic resonance determination of intramolecular distances in bovine pancreatic trypsin inhibitor using nitrotyrosine chelation of lanthanides. Nitration of tyrosine has been investigated as a means for chemically introducing lanthanide chelating sites at known positions in proteins. The low-field portions of... | [
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PMID:9978 | Existence of electrogenic hydrogen ion/sodium ion antiport in Halobacterium halobium cell envelope vesicles. | Illumination causes the extrusion of protons from Halobacterium halobium cell envelope vesicles, as a result of the action of light on bacteriorhodopsin. The protonmotive force developed is coupled to the active transport of Na+ out of the vesicles. The light-dependent ion fluxes in these vesicles were studied by follo... | Existence of electrogenic hydrogen ion/sodium ion antiport in Halobacterium halobium cell envelope vesicles. Illumination causes the extrusion of protons from Halobacterium halobium cell envelope vesicles, as a result of the action of light on bacteriorhodopsin. The protonmotive force developed is coupled to the active... | [
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PMID:9979 | Fractionation of DNA from mammalian cells by alkaline elution. | The method of alkaline elution provides a sensitive measure of DNA single-strand length distribution in mamalian cells and is applicable to a variety of problems concerning DNA damage, repair, and replication. The physical basis of the elution process was studied. The kinetics of elution above the alkaline transition p... | Fractionation of DNA from mammalian cells by alkaline elution. The method of alkaline elution provides a sensitive measure of DNA single-strand length distribution in mamalian cells and is applicable to a variety of problems concerning DNA damage, repair, and replication. The physical basis of the elution process was s... | [
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PMID:9980 | Polymerization pattern of insulin at pH 7.0. | Sedimentation equilibrium results, obtained with bovine zinc-free insulin (with and without a component of proinsulin) at pH 7.0, I o.2, 25 degrees C, and up to a total concentration of 0.8 g/l., are shown to be consistent with three different polymerization patterns, all involving an isodesmic indefinite self-associat... | Polymerization pattern of insulin at pH 7.0. Sedimentation equilibrium results, obtained with bovine zinc-free insulin (with and without a component of proinsulin) at pH 7.0, I o.2, 25 degrees C, and up to a total concentration of 0.8 g/l., are shown to be consistent with three different polymerization patterns, all in... | [
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PMID:9981 | Double-ternary complex affinity chromatography: preparation of alcohol dehydrogenases. | A general affinity chromatographic method for alcohol dehydrogenase purification has been developed by employing immobilized 4-substituted pyrazole derivatives that isolate the enzyme through formation of a specific ternary complex. Sepharose 4B is activated with 300 mg of cyanogen bromide/ml of packed gel and coupled ... | Double-ternary complex affinity chromatography: preparation of alcohol dehydrogenases. A general affinity chromatographic method for alcohol dehydrogenase purification has been developed by employing immobilized 4-substituted pyrazole derivatives that isolate the enzyme through formation of a specific ternary complex. ... | [
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PMID:9982 | Human liver alcohol dehydrogenase: purification, composition, and catalytic features. | Alcohol dehydrogenase has been purified from human liver by affinity chromatography. Ultracentrifugation, Sephadex G-200 chromatography, and amino acid analyses of multiple preparations demonstrate homogeneity of molecular weight. Sodium dodecyl sulfate disc gel electrophoresis reveals a single species of molecular wei... | Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Alcohol dehydrogenase has been purified from human liver by affinity chromatography. Ultracentrifugation, Sephadex G-200 chromatography, and amino acid analyses of multiple preparations demonstrate homogeneity of molecular weight. Sod... | [
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PMID:9983 | Regulatory properties of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa. Kinetic studies and fluorescence titration. | Mechanisms involved in the action of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa (EC 1.6.1.1) have been investigated by means of kinetic studies and fluorescence titration. Our results, as well as those from previous investigations, suggest that the allosteric MWC model (Monod, J., Wyman, J., a... | Regulatory properties of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa. Kinetic studies and fluorescence titration. Mechanisms involved in the action of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa (EC 1.6.1.1) have been investigated by means of kinetic studies and fluores... | [
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PMID:9984 | Regulatory properties of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa. Active enzyme ultracentrifugation studies. | Active enzyme ultracentrifugation studies of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa (EC 1.6.1.1.) show that the enzymatic reaction is catalyzed by a molecular species characterized by an S20,W value of about 34 S, whatever the reduced substrate may be (tri- or diphosphopyridine nucleotide)... | Regulatory properties of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa. Active enzyme ultracentrifugation studies. Active enzyme ultracentrifugation studies of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa (EC 1.6.1.1.) show that the enzymatic reaction is catalyzed by a mol... | [
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PMID:9985 | Coenzyme binding by triphosphopyridine nucleotide dependent isocitrate dehydrogenase from beef liver. Equilibrium and kinetics studies. | The binding of reduced nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide phosphate (NADP) dependent isocitrate dehydrogenase from beef liver cytoplasm was studied by several equilibrium techniques (ultracentrifugation, molecular sieving, ultrafiltration, fluorescence). Two binding... | Coenzyme binding by triphosphopyridine nucleotide dependent isocitrate dehydrogenase from beef liver. Equilibrium and kinetics studies. The binding of reduced nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide phosphate (NADP) dependent isocitrate dehydrogenase from beef liver cyto... | [
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PMID:9986 | Oxidation-reduction potential measurements on chloroperoxidase and its complexes. | The oxidation-reduction potential of chloroperoxidase, an enzyme which catalyzes peroxidative chlorination, bromination, and iodination reactions, has been investigated. In addition to catalyzing biological halogenation reactions, chloroperoxidase is unusual in that the carbon monoxide complex of ferrous chloroperoxida... | Oxidation-reduction potential measurements on chloroperoxidase and its complexes. The oxidation-reduction potential of chloroperoxidase, an enzyme which catalyzes peroxidative chlorination, bromination, and iodination reactions, has been investigated. In addition to catalyzing biological halogenation reactions, chlorop... | [
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PMID:9987 | The influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung. | It has been previously reported that fasting may result in decreased lung surfactant production. In order to investigate this relationship and the role of nutrition in lung phospholipid synthesis, 21-day-old rats were exposed for 60 h to one of five dietary regimens: standard rat chow (controls), fasting, pure glucose,... | The influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung. It has been previously reported that fasting may result in decreased lung surfactant production. In order to investigate this relationship and the role of nutrition in lung phospholipid synthesis, 21-day-old rats were... | [
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PMID:9988 | Regulatory control and function of alanine dehydrogenase from a thermophilic bacillus. | L-alanine dehydrogenase, (L-alanine:NAD+ oxidoreductase (deaminating), EC 1.4.1.1) synthesis in a thermophilic bacillus was found to be subjected to regulatory control. Addition of L- and D-alanine and L-serine to cultures growing in the presence of either succinate or pyruvate, induced an accelerated synthesis of the ... | Regulatory control and function of alanine dehydrogenase from a thermophilic bacillus. L-alanine dehydrogenase, (L-alanine:NAD+ oxidoreductase (deaminating), EC 1.4.1.1) synthesis in a thermophilic bacillus was found to be subjected to regulatory control. Addition of L- and D-alanine and L-serine to cultures growing in... | [
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PMID:9989 | Studies on phenylalanine and tyrosine hydroxylation by rat brain tyrosine hydroxylase. | Tyrosine hydroxylase (EC1.14.16.2), presumably the rate-limiting enzyme in the biosynthesis of catecholamines, is known to catalyze the hydroxylation of both phenylalanine and tyrosine. Using both an isolated enzyme preparation and a synaptosomal preparation, where some architectural integrity of the tissue has been pr... | Studies on phenylalanine and tyrosine hydroxylation by rat brain tyrosine hydroxylase. Tyrosine hydroxylase (EC1.14.16.2), presumably the rate-limiting enzyme in the biosynthesis of catecholamines, is known to catalyze the hydroxylation of both phenylalanine and tyrosine. Using both an isolated enzyme preparation and a... | [
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PMID:9990 | Kinetic studies of Rhus vernicifera laccase. Role of the metal centers in electron transfer. | The reactions of Rhus vernicifera (monophenol,dihydroxyphenylalanine: oxygen oxidoreductase, EC 1.14.18.1) with the reducing substrates hydroquinone and ascorbic acid have been investigated with the stopped-flow technique. Rhus laccase appears to be present in two molecular forms with a pH-sensitive equilibrium constan... | Kinetic studies of Rhus vernicifera laccase. Role of the metal centers in electron transfer. The reactions of Rhus vernicifera (monophenol,dihydroxyphenylalanine: oxygen oxidoreductase, EC 1.14.18.1) with the reducing substrates hydroquinone and ascorbic acid have been investigated with the stopped-flow technique. Rhus... | [
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PMID:9991 | Evidence for sulfhydryl groups at the active site of catechol-O-methyltransferase. | Earlier studies using affinity labeling reagents have suggested the existence of two nucleophilic groups at the active site of catechol-O-methyltransferase (S-adenosyl-L-methionine:catechol O-methyltransferase, EC 2.1.1.6). Both nucleophilic residues are critical for catalytic activity. In an effort to elucidate the na... | Evidence for sulfhydryl groups at the active site of catechol-O-methyltransferase. Earlier studies using affinity labeling reagents have suggested the existence of two nucleophilic groups at the active site of catechol-O-methyltransferase (S-adenosyl-L-methionine:catechol O-methyltransferase, EC 2.1.1.6). Both nucleoph... | [
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PMID:9992 | Microheterogeneity of arylsulfatase A from human tissues. | Human arylsulfatase A (cerebroside-3-sulfate 3-sulfohydrolase, EC 3.1.6.8) exhibited microheterogeneity on isoelectric focusing in polyacrylamide gels. Pure urinary enzyme gave 3 bands of activity with pI values of 4.7, 4.8 and 4.9, whereas purified liver enzyme yielded six equally spaced bands from pI 4.4 to 4.9. Dete... | Microheterogeneity of arylsulfatase A from human tissues. Human arylsulfatase A (cerebroside-3-sulfate 3-sulfohydrolase, EC 3.1.6.8) exhibited microheterogeneity on isoelectric focusing in polyacrylamide gels. Pure urinary enzyme gave 3 bands of activity with pI values of 4.7, 4.8 and 4.9, whereas purified liver enzyme... | [
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PMID:9993 | Coupling of the Penicillium duponti acid protease to ethylene-maleic acid (1 : 1) linear copolymer. Preparation and properties of the water-soluble derivative. | The coupling of the thermostable acid protease (EC 3.4.23.-) of Penicillium duponti K 1014 to ethylene-maleic acid (1 : 1) linear copolymer in the presence of 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide at pH 3.0, afforded a soluble enzyme derivative with a protein incorporation yield of 67% under optimal condition... | Coupling of the Penicillium duponti acid protease to ethylene-maleic acid (1 : 1) linear copolymer. Preparation and properties of the water-soluble derivative. The coupling of the thermostable acid protease (EC 3.4.23.-) of Penicillium duponti K 1014 to ethylene-maleic acid (1 : 1) linear copolymer in the presence of 1... | [
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PMID:9994 | Neutral elastolytic proteinase from canine leucocytes. Purification and characterization. | 1. A neutral proteinase (EC 3.4.-.-) with elastolytic activity was isolated from canine bloodstream leucocytes, and purified to apparent homogeneity by a two-step procedure consisting of DEAE-Sephadex chromatography and molecular sieving on Sephadex G-75. 2. The molecular weight of the enzyme was 23 500, and the absorb... | Neutral elastolytic proteinase from canine leucocytes. Purification and characterization. 1. A neutral proteinase (EC 3.4.-.-) with elastolytic activity was isolated from canine bloodstream leucocytes, and purified to apparent homogeneity by a two-step procedure consisting of DEAE-Sephadex chromatography and molecular ... | [
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PMID:9995 | Purification and properties of the extracellular metallo-proteinases of Chromobacterium lividum (NCIB 10926). | Four extracellular proteolytic enzymes (I-IV) (EC 3.4.22.-) were identified in static cultures of Chromobacterium lividum (NCIB 10926) by agar gel electrophoresis and isoelectric focusing. Proteinases I-III were freed of non-enzymic protein by chromatography on TEAE-cellulose and CM-cellulose. The enzyme mixture was th... | Purification and properties of the extracellular metallo-proteinases of Chromobacterium lividum (NCIB 10926). Four extracellular proteolytic enzymes (I-IV) (EC 3.4.22.-) were identified in static cultures of Chromobacterium lividum (NCIB 10926) by agar gel electrophoresis and isoelectric focusing. Proteinases I-III wer... | [
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PMID:9996 | Photocontrol of urease activity in spiropyran collagen membrane. | 1. Collagen fibrils were modified with beta-1-[3,3-dimethyl-6'-nitrospiro-(indoline-2,2'-2H-benzopyran)] propionic anhydride. 2. Urease (urea amidohydrolase, EC 3.5.1.5) was immobilized in spiropyran collagen membrane. The activity of the urease-spiropyran collagen membrane was found to increase in the dark and then de... | Photocontrol of urease activity in spiropyran collagen membrane. 1. Collagen fibrils were modified with beta-1-[3,3-dimethyl-6'-nitrospiro-(indoline-2,2'-2H-benzopyran)] propionic anhydride. 2. Urease (urea amidohydrolase, EC 3.5.1.5) was immobilized in spiropyran collagen membrane. The activity of the urease-spiropyra... | [
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PMID:9997 | Magnetic studies of Chromatium flavocytochrome C552. A mechanism for heme-flavin interaction. | Electron paramagnetic resonance and magnetic susceptibility studies of Chromatium flavocytochrome C552 and its diheme flavin-free subunit at temperatures below 45 degrees K are reported. The results show that in the intact protein and the subunit the two low-spin (S = 1/2) heme irons are distinguishable, giving rise to... | Magnetic studies of Chromatium flavocytochrome C552. A mechanism for heme-flavin interaction. Electron paramagnetic resonance and magnetic susceptibility studies of Chromatium flavocytochrome C552 and its diheme flavin-free subunit at temperatures below 45 degrees K are reported. The results show that in the intact pro... | [
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PMID:9998 | Conformational transitions of monellin, an intensely sweet protein. | Conformational transitions of monellin, an intensely sweet protein from the berries of Dioscoreophyllum cumminsii, were studied by the circular dichroism (CD) probe. According to the CD spectra, monellin has a low content of the helical structure and a significant amount of the pleated sheet (beta) conformation. The na... | Conformational transitions of monellin, an intensely sweet protein. Conformational transitions of monellin, an intensely sweet protein from the berries of Dioscoreophyllum cumminsii, were studied by the circular dichroism (CD) probe. According to the CD spectra, monellin has a low content of the helical structure and a... | [
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PMID:9999 | In vitro activation of glycoprotein hormones. Hybridization of subunits from thyrotropin, lutropin and human choriogonadotropin. | In vitro assembly of thyrotropin alpha and beta subunits led to an increase in content of alpha helix and beta sheet very similar to that found for gonadotropins. This association-dependent active folding involved the burying of three tyrosine residues tentatively assigned to Tyr alpha 41, Tyr beta 37 and Tyr beta 59 a... | In vitro activation of glycoprotein hormones. Hybridization of subunits from thyrotropin, lutropin and human choriogonadotropin. In vitro assembly of thyrotropin alpha and beta subunits led to an increase in content of alpha helix and beta sheet very similar to that found for gonadotropins. This association-dependent a... | [
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PMID:10000 | A new method for the determination of alpha1-protease inhibitor (alpha1-antitrypsin) phenotypes based on the formation of alpha1-protease inhibitor allele product-elastase complexes. | Up until now it has been assumed that the protease-binding property of alpha1-protease inhibitor (alpha1PI) was destroyed by acid starch gel electrophoresis (pH 4.9). Analyses on acid starch gel blocks for pH and conductivity changes during and following a typical electrophoretic run showed that it was unlikely that th... | A new method for the determination of alpha1-protease inhibitor (alpha1-antitrypsin) phenotypes based on the formation of alpha1-protease inhibitor allele product-elastase complexes. Up until now it has been assumed that the protease-binding property of alpha1-protease inhibitor (alpha1PI) was destroyed by acid starch ... | [
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PMID:10001 | Study of the biological significance of cytochrome methylation. I. Thermal, acid and guanidinium hydrochloride denaturations of baker's yeast ferricytochromes c. | The iso-cytochromes c from baker's yeast: iso-1 methylated and unmethylated forms and iso-2 have been purified and their stabilities towards denaturants compared to that of horse heart cytochrome c. Thermal, acid and guanidinium hydrochloride denaturations were followed using fluorescence emission of their tryptophan 5... | Study of the biological significance of cytochrome methylation. I. Thermal, acid and guanidinium hydrochloride denaturations of baker's yeast ferricytochromes c. The iso-cytochromes c from baker's yeast: iso-1 methylated and unmethylated forms and iso-2 have been purified and their stabilities towards denaturants compa... | [
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PMID:10002 | Physical studies on the size and structure of the covalently closed circular chloroplast DNA from higher plants. | The size and structure of the covalently closed circular chloroplast DNAs (ctDNA) from pea, lettuce, and spinach plants, have been studied by analytical ultracentrifugation. The values of so20,w,Na+ of the native and denatured forms of the open and closed circular DNAs from these plants have been determined. The absolu... | Physical studies on the size and structure of the covalently closed circular chloroplast DNA from higher plants. The size and structure of the covalently closed circular chloroplast DNAs (ctDNA) from pea, lettuce, and spinach plants, have been studied by analytical ultracentrifugation. The values of so20,w,Na+ of the n... | [
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PMID:10003 | Further characterization of a DNA polymerase activity in mouse sperm nuclei. | The presence of a nuclear DNA polymerase in mouse sperm from adult testes has been confirmed and the properties of this enzyme further investigated. This activity was shown to be greatly enhanced by treating the spermatozoa with methanol or ethanol before incubation in the reaction medium or by their addition in small ... | Further characterization of a DNA polymerase activity in mouse sperm nuclei. The presence of a nuclear DNA polymerase in mouse sperm from adult testes has been confirmed and the properties of this enzyme further investigated. This activity was shown to be greatly enhanced by treating the spermatozoa with methanol or et... | [
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PMID:10004 | The rye embryo system as an alternative to the wheat system for protein synthesis in vitro. | Isolated rye embryos are a readily available source for the preparation of very active, cell-free, protein-synthesizing systems. Incorporation levels up to 2000 pmol leucine per 50 mul assay are routinely obtained at saturating TMV (Tobacco mosaic virus) RNA concentrations; at limiting messenger RNA concentrations the ... | The rye embryo system as an alternative to the wheat system for protein synthesis in vitro. Isolated rye embryos are a readily available source for the preparation of very active, cell-free, protein-synthesizing systems. Incorporation levels up to 2000 pmol leucine per 50 mul assay are routinely obtained at saturating ... | [
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PMID:10005 | Raman pH profiles for nucleic acid constituents I. Cytidine and uridine ribonucleosides. | Raman spectra of aqueous solutions of uridine and cytidine have been recorded as a function of pH with the band intensities and vibrational frequencies monitored to determine bands which may be considered as diagnostic of the concentration of the various species. Quantitative band intensity measurements indicate that n... | Raman pH profiles for nucleic acid constituents I. Cytidine and uridine ribonucleosides. Raman spectra of aqueous solutions of uridine and cytidine have been recorded as a function of pH with the band intensities and vibrational frequencies monitored to determine bands which may be considered as diagnostic of the conce... | [
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PMID:10006 | Raman ph profiles for nucleic acid constituents. II. 5'-AMP and 5'-GMP ribonucleotides. | Raman spectra of aqueous solutions of 5'-AMP and 5'-GMP have been recorded as a function of pH. Band intensities and frequencies have been monitored to determine bands which may be considered as diagnostic for the concentration and the pK of the solution species. Quantitative band intensity measurements indicate only a... | Raman ph profiles for nucleic acid constituents. II. 5'-AMP and 5'-GMP ribonucleotides. Raman spectra of aqueous solutions of 5'-AMP and 5'-GMP have been recorded as a function of pH. Band intensities and frequencies have been monitored to determine bands which may be considered as diagnostic for the concentration and ... | [
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PMID:10007 | Solubility of phospholipid polar group model compounds in water. | The aqueous solubilities of the Na+ and Ca2+ salts and the free acid forms of phosphorylcholine, phosphorylethanolamine and D,L-phospho-serine, respectively, were found to be below the polar group concentrations calculated for bilayers of the corresponding phospholipids. | Solubility of phospholipid polar group model compounds in water. The aqueous solubilities of the Na+ and Ca2+ salts and the free acid forms of phosphorylcholine, phosphorylethanolamine and D,L-phospho-serine, respectively, were found to be below the polar group concentrations calculated for bilayers of the correspondin... | [
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PMID:10008 | Photophosphorylation as a function of illumination time. II. Effects of permeant buffers. | (1) The amounts of orthophosphate, bicarbonate and tris (hydroxymethyl)-aminomethane found inside the thylakoid are almost exactly the amounts predicted by assuming that the buffers equilibrate across the membrane. Since imidazole and pyridine delay the development of post-illumination ATP formation while increasing th... | Photophosphorylation as a function of illumination time. II. Effects of permeant buffers. (1) The amounts of orthophosphate, bicarbonate and tris (hydroxymethyl)-aminomethane found inside the thylakoid are almost exactly the amounts predicted by assuming that the buffers equilibrate across the membrane. Since imidazole... | [
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PMID:10009 | Effect of ionophores A23187 and nigericin on the light-induced redistribution of Mg2+, K+ and H+ across the thylakoid membrane. | Passive redistributions of Mg2+ and K+ ions across the thylakoid membranes, occurring in association with the light-driven electrogenic influx of hydrogen ions have been examined in suspensions of broken spinach chloroplasts under a variety of conditions. (i) In accord with results of Hind el al. (Proc. Natl. Acad. Sci... | Effect of ionophores A23187 and nigericin on the light-induced redistribution of Mg2+, K+ and H+ across the thylakoid membrane. Passive redistributions of Mg2+ and K+ ions across the thylakoid membranes, occurring in association with the light-driven electrogenic influx of hydrogen ions have been examined in suspension... | [
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PMID:10010 | Electron paramagnetic resonance spectra of mitochondrial and microsomal cytochrome P-450 from the rat adrenal. | The electron paramagnetic resonance (EPR) spectra of rat adrenal zona fasciculate mitochondria showed peaks corresponding to low spin ferric cytochrome P-450 with apparent g values of 2.424, 2.248 and 1.917, and weak signals due to high spin ferric cytochrome P-450 with gx values of 8.08 and 7.80. The former is attribu... | Electron paramagnetic resonance spectra of mitochondrial and microsomal cytochrome P-450 from the rat adrenal. The electron paramagnetic resonance (EPR) spectra of rat adrenal zona fasciculate mitochondria showed peaks corresponding to low spin ferric cytochrome P-450 with apparent g values of 2.424, 2.248 and 1.917, a... | [
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PMID:10011 | Secretion of lecithin: cholesterol acyltransferase from isolated rat hepatocytes. | 1. Lecithin:cholesterol acyltransferase is secreted from isolated rat heptocytes. 2. The secretion is stimulated when serum is added to the incubation medium. 3. Optimal conditions for secretion are: 5-10(6) hepatocytes per ml, 5 h incubation, pH 7.3-7.4 and 25% serum in the incubation medium. 4. Concomitantly with the... | Secretion of lecithin: cholesterol acyltransferase from isolated rat hepatocytes. 1. Lecithin:cholesterol acyltransferase is secreted from isolated rat heptocytes. 2. The secretion is stimulated when serum is added to the incubation medium. 3. Optimal conditions for secretion are: 5-10(6) hepatocytes per ml, 5 h incuba... | [
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PMID:10012 | Distinct testicular 17-ketosteroid reductases, one in interstitial tissue and one in seminiferous tubules. Differential modulation by testosterone and metabolites of testosterone. | The final step in the biosynthesis of testosterone is the reduction of androstenedione, which is catalyzed by the microsomal enzyme 17-ketosteroid reductase. Evidence is presented which suggests that there are two distinct 17-ketosteroid reductases in rat testes, one in interstitial tissue and one in seminiferous tubul... | Distinct testicular 17-ketosteroid reductases, one in interstitial tissue and one in seminiferous tubules. Differential modulation by testosterone and metabolites of testosterone. The final step in the biosynthesis of testosterone is the reduction of androstenedione, which is catalyzed by the microsomal enzyme 17-ketos... | [
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PMID:10013 | [Cathepsin D from horse spleen. II. Study of certain enzymatic properties]. | This work reports some enzymatic properties of highly purified horse spleen cathepsin D. Hydrolysis rate of several proteins are compared. The Kinetic constants (Km = 4.95 10(-5) M and Vm = 1,76 delta DO/mn/mug) have been determined in the presence of a denatured haemoglobin substrate. Stability of the enzymatic prepar... | [Cathepsin D from horse spleen. II. Study of certain enzymatic properties]. This work reports some enzymatic properties of highly purified horse spleen cathepsin D. Hydrolysis rate of several proteins are compared. The Kinetic constants (Km = 4.95 10(-5) M and Vm = 1,76 delta DO/mn/mug) have been determined in the pres... | [
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PMID:10014 | The chemical ecology of Biomphalaria glabrata: the effects of ammonia on the growth rate of juvenile snails. | When juvenile specimens of Biomphalaria glabrata were subjected to concentrations of ammonia ranging from 1-100 mug/ml in various media the following effects were observed: the addition of ammonia to borate buffered media caused mortality. Both borate and tris-buffered media caused a decrease in the growth rate of snai... | The chemical ecology of Biomphalaria glabrata: the effects of ammonia on the growth rate of juvenile snails. When juvenile specimens of Biomphalaria glabrata were subjected to concentrations of ammonia ranging from 1-100 mug/ml in various media the following effects were observed: the addition of ammonia to borate buff... | [
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PMID:10015 | [Spectral effects of denaturation of B- and C-phycoerythrins]. | B-phycoerythrin (B-PhE) from red alga Porphyridium cruentum and C-phycoerythrin (C-PhE) from blue-green alga Nostoc punctiforma were isolated. Their absorption and fluorescence spectra were measured at room and liquid nitrogen temperature. The drastic change of fluorescence and absorption maxima under dissociation of t... | [Spectral effects of denaturation of B- and C-phycoerythrins]. B-phycoerythrin (B-PhE) from red alga Porphyridium cruentum and C-phycoerythrin (C-PhE) from blue-green alga Nostoc punctiforma were isolated. Their absorption and fluorescence spectra were measured at room and liquid nitrogen temperature. The drastic chang... | [
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PMID:10016 | [Catalytic properties and stability of horseradish peroxidase immobilized in polyacrylamide gel]. | Effect of polyacrylamide (PAA) gel on properties of horseradish peroxidase, immobilized by means of the incorporation into PAA gel is studied. Catalytic properties of immobilized enzyme are studied. Km value and pH-dependency of the enzyme activity are found to be close to those of soluble enzyme, kcat value is 3 times... | [Catalytic properties and stability of horseradish peroxidase immobilized in polyacrylamide gel]. Effect of polyacrylamide (PAA) gel on properties of horseradish peroxidase, immobilized by means of the incorporation into PAA gel is studied. Catalytic properties of immobilized enzyme are studied. Km value and pH-depende... | [
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PMID:10017 | Acid-base changes of mature and premature neonates following exchange transfusion. | The changes of acid-base values of 60 mature and premature neonates treated by exchange transfusion were followed. It could be shown that the blood conserves having acidic pH values caused no acidosis if the acid-base balance of the patients had been normal before transfusion. An existing acidosis frequently increased ... | Acid-base changes of mature and premature neonates following exchange transfusion. The changes of acid-base values of 60 mature and premature neonates treated by exchange transfusion were followed. It could be shown that the blood conserves having acidic pH values caused no acidosis if the acid-base balance of the pati... | [
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PMID:10019 | Active enzyme gel chromatography. I. Experimental aspects. | Transport properties of active enzyme species can be studied effectively by layering a small band of enzyme-containing sample on a gel chromatographic column previously saturated with substrate. The column is optically scanned at successive time intervals to yield profiles representing the appearance of chromophoric pr... | Active enzyme gel chromatography. I. Experimental aspects. Transport properties of active enzyme species can be studied effectively by layering a small band of enzyme-containing sample on a gel chromatographic column previously saturated with substrate. The column is optically scanned at successive time intervals to yi... | [
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PMID:10020 | A calorimetric study of polyguanylic acid at neutral pH. | The structure of polyguanylic acid (poly G) at neutral pH has been studied by optical and calorimetrical methods. It can be shown that diverging from earlier findings Poly G reversibly undergoes a cooperative thermal transition. Thermal denaturation curves are recorded at 253 nm as a function of the sodium ion concentr... | A calorimetric study of polyguanylic acid at neutral pH. The structure of polyguanylic acid (poly G) at neutral pH has been studied by optical and calorimetrical methods. It can be shown that diverging from earlier findings Poly G reversibly undergoes a cooperative thermal transition. Thermal denaturation curves are re... | [
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PMID:10021 | Electron transport by C-type cytochromes. I. The reaction of horse heart cytochrome c with anionic reductants. | The kinetics of reduction of horse heartcytochrome c have been investigated using the reductants sodium dithionite and potassium ferrocyanide. Sodium dithionite reduction at pH 7.0 yields rate constants of 2.8 X 10(8)M(-1)sec-1 for SO2 AND 6 X 10(5) M-1 sec-1 for S2O4 at infinite dilution. Moreover, the data presented ... | Electron transport by C-type cytochromes. I. The reaction of horse heart cytochrome c with anionic reductants. The kinetics of reduction of horse heartcytochrome c have been investigated using the reductants sodium dithionite and potassium ferrocyanide. Sodium dithionite reduction at pH 7.0 yields rate constants of 2.8... | [
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PMID:10022 | Flash photometric experiments on the photochemical cycle of bacteriorhodopsin. | The photochemical reaction cycle of bacteriorhodopsin was investigated by means of flash photometric methods. Three different intermediates with absorption maxima at about 630 nm, 411 nm, and 646 nm could be detected. Kinetic data of the occurrence of these intermediates were obtained from isolated purple membrane in d... | Flash photometric experiments on the photochemical cycle of bacteriorhodopsin. The photochemical reaction cycle of bacteriorhodopsin was investigated by means of flash photometric methods. Three different intermediates with absorption maxima at about 630 nm, 411 nm, and 646 nm could be detected. Kinetic data of the occ... | [
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PMID:10024 | A new alkali-resistant hemoglobin alpha2J Oxford gammaF2 in a Sicilian baby girl with homozygous beta0 thalassemia. | A 10-mo-old baby girl with homozygous beta0 thalassemia and alphaJOxford, presenting the clinical picture of homozygous beta thalassemia is described. Hemoglobin electrophoresis showed three bands: the first two with the mobilities of hemoglobin Hb A2 (1%) and Hb F (69%), respectively, the third migrating a little fast... | A new alkali-resistant hemoglobin alpha2J Oxford gammaF2 in a Sicilian baby girl with homozygous beta0 thalassemia. A 10-mo-old baby girl with homozygous beta0 thalassemia and alphaJOxford, presenting the clinical picture of homozygous beta thalassemia is described. Hemoglobin electrophoresis showed three bands: the fi... | [
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PMID:10025 | Effect of osmotic pressure, ionic strength and dibutyryl cyclic adenosine monophosphate on the adhesion of hen erythrocytes. | In the presence of lysolecithin at physiological pH it was found that the increase of ionic strength facilitates the adhesion of hen erythrocytes. In this medium, dibutyryl cyclic adenosine monophosphate (DBcAMP) increases the adhesion index of the cells. If the osmotic pressure is elevated without a proper increase of... | Effect of osmotic pressure, ionic strength and dibutyryl cyclic adenosine monophosphate on the adhesion of hen erythrocytes. In the presence of lysolecithin at physiological pH it was found that the increase of ionic strength facilitates the adhesion of hen erythrocytes. In this medium, dibutyryl cyclic adenosine monop... | [
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PMID:10028 | Report of the first hemispheric meeting on meningococcal disease. | The first Hemispheric meeting on meningococcal meningitis was held in São Paulo and Brasília on 23-28 February 1976. Organized by the Pan American Health Organization in collaboration with the Government of Brazil and other PAHO Member States, the meeting had three principal aims: to review the general subject of cereb... | Report of the first hemispheric meeting on meningococcal disease. The first Hemispheric meeting on meningococcal meningitis was held in São Paulo and Brasília on 23-28 February 1976. Organized by the Pan American Health Organization in collaboration with the Government of Brazil and other PAHO Member States, the meetin... | [
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PMID:10029 | The contribution of extraneuronal uptake to the trachea-blood vessel selectivity of beta-adrenoceptor stimulants in vitro in guinea-pigs. | 1 The potencies relative to isoprenaline of isoetharine, tertiary butyl noradrenaline, salbutamol, orciprenaline, Me 506, rimiterol, fenoterol, carbuterol and terbutaline on isolated preparations of guinea-pig trachea and blood vessels (perfused hind limb) were determined. All the compounds were selective for trachea a... | The contribution of extraneuronal uptake to the trachea-blood vessel selectivity of beta-adrenoceptor stimulants in vitro in guinea-pigs. 1 The potencies relative to isoprenaline of isoetharine, tertiary butyl noradrenaline, salbutamol, orciprenaline, Me 506, rimiterol, fenoterol, carbuterol and terbutaline on isolated... | [
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PMID:10034 | Adrenoreceptors of the guinea-pig urinary bladder. | 1 Adrenaline, noradrenaline and isoprenaline (5 mug/ml) did not affect the resting tone of the isolated urinary bladder of the guinea-pig. 2 The catecholamines (1-2 mug/ml) inhibited neuronally evoked contractions at various stimulation frequencies; the inhibition was maximum at 2 Hz and minimum at 50 Hz. Isoprenaline ... | Adrenoreceptors of the guinea-pig urinary bladder. 1 Adrenaline, noradrenaline and isoprenaline (5 mug/ml) did not affect the resting tone of the isolated urinary bladder of the guinea-pig. 2 The catecholamines (1-2 mug/ml) inhibited neuronally evoked contractions at various stimulation frequencies; the inhibition was ... | [
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PMID:10035 | The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. | 1 A new in vitro preparation, the isolated lung strip of the cat, is described for investigating the direct effect of drugs on the smooth muscle of the peripheral airways of the lung. The preparation comprises a thin strip of lung parenchyma which can be mounted in a conventional organ bath for isometric tension record... | The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. 1 A new in vitro preparation, the isolated lung strip of the cat, is described for investigating the direct effect of drugs on the smooth m... | [
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PMID:10036 | Imaginal flooding and exposure to real phobic situations: treatment outcome with agoraphobic patients. | Each of thirty-six female agoraphobic out-patients were treated by one of three methods: 8 sessions of imaginal flooding followed by 8 sessions of practice in the real situation; 16 sessions of combined flooding and practice; or 16 sessions of practice alone. Three therapists treated equal numbers of patients in each g... | Imaginal flooding and exposure to real phobic situations: treatment outcome with agoraphobic patients. Each of thirty-six female agoraphobic out-patients were treated by one of three methods: 8 sessions of imaginal flooding followed by 8 sessions of practice in the real situation; 16 sessions of combined flooding and p... | [
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PMID:10037 | Imaginal flooding and exposure to real phobic situations: changes during treatment. | This paper reports the results of measures taken during treatment in the study of imaginal flooding and exposure to real phobic situations previously described by Mathews, Johnston, Lancashire, Munby, Shaw and Gelder (1976). On weekly measures of change of similar reduction in phobic behaviour in all treatments was fou... | Imaginal flooding and exposure to real phobic situations: changes during treatment. This paper reports the results of measures taken during treatment in the study of imaginal flooding and exposure to real phobic situations previously described by Mathews, Johnston, Lancashire, Munby, Shaw and Gelder (1976). On weekly m... | [
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PMID:10038 | Fresh symptom emergence after intensive behaviour therapy. | The outcome of a standard four-day intensive symptomatic treatment programme with 39 agoraphobics is examined in relation to the incidence of fresh symptom emergence. Twenty-six patients suffered fresh symptom emergence during follow-up, and there was a significant association of fresh symptom emergence with poorer out... | Fresh symptom emergence after intensive behaviour therapy. The outcome of a standard four-day intensive symptomatic treatment programme with 39 agoraphobics is examined in relation to the incidence of fresh symptom emergence. Twenty-six patients suffered fresh symptom emergence during follow-up, and there was a signifi... | [
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PMID:10039 | Personality, expectancies and group psychotherapy. | The paper reports an extension of work into the relevance of personality and pre-treatment expectancies for allocation and response of patients to group psychotherapy. The results show that subjects who are internally directed in interest and who have a liberal attitude to a variety of social issues and a "psychologica... | Personality, expectancies and group psychotherapy. The paper reports an extension of work into the relevance of personality and pre-treatment expectancies for allocation and response of patients to group psychotherapy. The results show that subjects who are internally directed in interest and who have a liberal attitud... | [
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PMID:10049 | Further characterization of morphine-like peptides (endorphins) from pituitary. | Pituitary peptides with opioid pharmacologic action (endorphins) can exist in several forms with different basicities and molecular weights from about 3000 to less than 1000 daltons. Partial purification yielded an endorphin at least 4 times more potent than normorphine and 16 times more potent than the endogenous brai... | Further characterization of morphine-like peptides (endorphins) from pituitary. Pituitary peptides with opioid pharmacologic action (endorphins) can exist in several forms with different basicities and molecular weights from about 3000 to less than 1000 daltons. Partial purification yielded an endorphin at least 4 time... | [
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PMID:10050 | Separately developing axonal uptake of 5-hydroxytryptamine and norepinephrine in the fetal ileum of the rabbit. | Uptake of 5-hydroxytryptamine (5-HT) by adult and fetal rabbit's ileum was studied. The adult myenteric plexus accumulated tritium when incubated with tritiated 5-HT. However, in addition to labeled 5-HT, tritiated 5-hydroxyindole acetic acid and, when monoamine oxidase (MAO) was inhibited, 5-HT-o-glucuronide were foun... | Separately developing axonal uptake of 5-hydroxytryptamine and norepinephrine in the fetal ileum of the rabbit. Uptake of 5-hydroxytryptamine (5-HT) by adult and fetal rabbit's ileum was studied. The adult myenteric plexus accumulated tritium when incubated with tritiated 5-HT. However, in addition to labeled 5-HT, tri... | [
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PMID:10051 | A comparison of the 12,000 dalton proteins synthesized by Aplysia neurons L11 and R15. | The 12,000 dalton proteins of neurons L11 and R15 of the Aplysia abdominal ganglion were labeled by incubation of the ganglion in [3H]leucine and compared in terms of their subcellular localization, solubility in various media, and molecular charge. Both proteins are cytoplasmic constituents. Their solubility behavior ... | A comparison of the 12,000 dalton proteins synthesized by Aplysia neurons L11 and R15. The 12,000 dalton proteins of neurons L11 and R15 of the Aplysia abdominal ganglion were labeled by incubation of the ganglion in [3H]leucine and compared in terms of their subcellular localization, solubility in various media, and m... | [
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PMID:10055 | [Consequences of the administration of alpha or beta drenolytic agents on the mobilization of plasma free fatty acids as induced by noradrenaline and isoprenaline in the dog]. | Noradrénaline or isoprenaline (a beta sympathicomimetic drug) infusion in fasting awake dog provoque a rise of plasmatic FFA. This effect is abolished by administration of propranolol (beta blocking agent) but not by phentolamine (alpha blocking agent). Phentolamine potentiate the rise of FFA in response to noradrenali... | [Consequences of the administration of alpha or beta drenolytic agents on the mobilization of plasma free fatty acids as induced by noradrenaline and isoprenaline in the dog]. Noradrénaline or isoprenaline (a beta sympathicomimetic drug) infusion in fasting awake dog provoque a rise of plasmatic FFA. This effect is abo... | [
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PMID:10056 | [Influence of variations in blood pH on the bronchodilator action of salbutamol and terbutaline]. | In the cat, the broncho-dilatator effects of salbutamol and terbutaline are influenced by blood pH variations. Gazeous or metabolic alkalosis increases, acidosis decreases, the broncho-dilatation provoked by salbutamol or terbutaline. | [Influence of variations in blood pH on the bronchodilator action of salbutamol and terbutaline]. In the cat, the broncho-dilatator effects of salbutamol and terbutaline are influenced by blood pH variations. Gazeous or metabolic alkalosis increases, acidosis decreases, the broncho-dilatation provoked by salbutamol or ... | [
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PMID:10057 | Effect of structural analogs of butaclamol (a new antipsychotic drug) on striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats. | The 3-isopropyl (I), 3-cyclohexyl (II) and 3-phenyl (III) analogs of the new antipsychotic drug butaclamol, which contains a 3-tertiary butyl group, and their respective (+)-enantiomers, but not (-)-enantiomers, caused a dose related elevation of rat striatal homovanillic acid concentration, indicative of an increased ... | Effect of structural analogs of butaclamol (a new antipsychotic drug) on striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats. The 3-isopropyl (I), 3-cyclohexyl (II) and 3-phenyl (III) analogs of the new antipsychotic drug butaclamol, which contains a 3-tertiary butyl group, and their respective ... | [
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PMID:10058 | Catalepsy induced by morphine or haloperidol: effects of apomorphine and anticholinergic drugs. | To investigate the extent of cholinergic involvement in opiate-induced catalepsy, the effects of three anticholinergic drugs were studied on morphine-induced catalepsy. Haloperidol-induced catalepsy was also examined. Maximum catalepsy in rats was obtained with 30 mg/kg morphine or 3 mg/kg haloperidol. The anticholiner... | Catalepsy induced by morphine or haloperidol: effects of apomorphine and anticholinergic drugs. To investigate the extent of cholinergic involvement in opiate-induced catalepsy, the effects of three anticholinergic drugs were studied on morphine-induced catalepsy. Haloperidol-induced catalepsy was also examined. Maximu... | [
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PMID:10059 | Behavioral studies on the enantiomers of butaclamol demonstrating absolute optical specificity for neuroleptic activity. | Butaclamol is a member of a new chemical class for which antipsychotic activity in humans has been demonstrated. Butaclamol, a racemate, has been resolved into its optical isomers and a separation of activities was found to occur between the (+) and (-) enantiomers. The present experiments show that at doses ranging fr... | Behavioral studies on the enantiomers of butaclamol demonstrating absolute optical specificity for neuroleptic activity. Butaclamol is a member of a new chemical class for which antipsychotic activity in humans has been demonstrated. Butaclamol, a racemate, has been resolved into its optical isomers and a separation of... | [
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PMID:10060 | Effects of acidity, cations and alcoholic fractionation on absorption of heparin from gastrointestinal tract. | Heparin was introduced into the stomach or duodenum of mice separately in doses of ca. 250 mg/kg. A slight anticoagulant effect in the systemic circulation was detected in whole blood clotting times and factor X inhibition. In contrast to most drugs, more heparin was absorbed from the stomach than from the intestine. S... | Effects of acidity, cations and alcoholic fractionation on absorption of heparin from gastrointestinal tract. Heparin was introduced into the stomach or duodenum of mice separately in doses of ca. 250 mg/kg. A slight anticoagulant effect in the systemic circulation was detected in whole blood clotting times and factor ... | [
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PMID:10061 | Extracellular nuclease produced by a marine bacterium. II. Purification and properties of extracellular nuclease from a marine Vibrio sp. | Extracellular nuclease produced by a marine Vibrio sp., strain No. 2, was purified by salting out with ammonium sulfate and by chromatography on a DEAE-cellulose column and twice on a Sephadex G-200 column. The nuclease was eluted as a single peak in which the deoxyribonuclease (DNase) activity and ribonuclease (RNase)... | Extracellular nuclease produced by a marine bacterium. II. Purification and properties of extracellular nuclease from a marine Vibrio sp. Extracellular nuclease produced by a marine Vibrio sp., strain No. 2, was purified by salting out with ammonium sulfate and by chromatography on a DEAE-cellulose column and twice on ... | [
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PMID:10062 | Ecological distribution of Spirillum lipoferum Beijerinck. | A survey in various countries revealed that the N2-fixing Spirillum lipoferum Beijerinck is a very common root and soil inhabitant in the tropics. More than half of the grass root and soil samples collected in tropical countries (four African countries and Brazil) contained abundant S. lipoferum populations, while less... | Ecological distribution of Spirillum lipoferum Beijerinck. A survey in various countries revealed that the N2-fixing Spirillum lipoferum Beijerinck is a very common root and soil inhabitant in the tropics. More than half of the grass root and soil samples collected in tropical countries (four African countries and Braz... | [
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0.011... |
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