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PMID:11724 | [Anesthesia for lung grafts]. | The problems of anaesthesia for pulmonary transplantation are discussed from the theoretical and practical points of view. The problems of elimination of carbon dioxide and adequate oxygenation of the arterial blood, and protection of the transplanted lung, are considered. In the phase immediately after transplantation... | [Anesthesia for lung grafts]. The problems of anaesthesia for pulmonary transplantation are discussed from the theoretical and practical points of view. The problems of elimination of carbon dioxide and adequate oxygenation of the arterial blood, and protection of the transplanted lung, are considered. In the phase imm... | [
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PMID:11725 | [Anesthesia and the postoperative period in non-urgent tracheal surgery. Apropos of 36 patients]. | The authors report 36 cases of resection and suture for stenosis or tumour of the trachea and give details of their technique of anaesthesia, the post-operative follow-up and their results. The development of fiber endoscopy and simplification of intubation, increases the security of the patient, facilitates the task o... | [Anesthesia and the postoperative period in non-urgent tracheal surgery. Apropos of 36 patients]. The authors report 36 cases of resection and suture for stenosis or tumour of the trachea and give details of their technique of anaesthesia, the post-operative follow-up and their results. The development of fiber endosco... | [
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PMID:11717 | Lorazepam premedication: lack of recall and relief of anxiety. | Premedication with lorazepam (4 mg), diazepam (10 mg), and a placebo was compared in a randomized, double-blind study of 95 adult surgical patients. Comparisons were made of recall of a memory card and events of the operative day, relief of anxiety, degree of somnolence, effects on blood pressure and heart rate, and in... | Lorazepam premedication: lack of recall and relief of anxiety. Premedication with lorazepam (4 mg), diazepam (10 mg), and a placebo was compared in a randomized, double-blind study of 95 adult surgical patients. Comparisons were made of recall of a memory card and events of the operative day, relief of anxiety, degree ... | [
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PMID:11726 | [Technic of pleural drainage (emergency pleural drainage)]. | Pleural effusion is still often poorly drained: - incorrect introduction of the drain into the thorax, - ill-chosen position of the drain. Simple drainage, a minima, is considered here, that which requires no broad surgical incision and which, in cases of effusion with compression of the lung, is often a life saving pr... | [Technic of pleural drainage (emergency pleural drainage)]. Pleural effusion is still often poorly drained: - incorrect introduction of the drain into the thorax, - ill-chosen position of the drain. Simple drainage, a minima, is considered here, that which requires no broad surgical incision and which, in cases of effu... | [
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PMID:11727 | [Tracheobronchial ruptures seen in emergencies. Viewpoint of the anesthesiologist]. | At the Marie Lannelongue surgical centre between 1964 and 1975, out of 278 patients with trauma of the thorax, we noted only 10 cases of tracheal-bronchial rupture admitted as an emergency = 9 ruptures due to closed trauma of the thorax, one with division of the lower part of the trachea. Analysis of these cases showed... | [Tracheobronchial ruptures seen in emergencies. Viewpoint of the anesthesiologist]. At the Marie Lannelongue surgical centre between 1964 and 1975, out of 278 patients with trauma of the thorax, we noted only 10 cases of tracheal-bronchial rupture admitted as an emergency = 9 ruptures due to closed trauma of the thorax... | [
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PMID:11728 | [Emergency treatment of tracheal and bronchial foreign bodies]. | Basing their report on personal experience of more than 300 tracheal or bronchial foreign bodies, the authors emphasize: -the difficulty of extraction, even in very expert hands. -the absolute necessity of a fully trained operator, and experienced anaesthetist and appropriate material. Apart from acute respiratory dist... | [Emergency treatment of tracheal and bronchial foreign bodies]. Basing their report on personal experience of more than 300 tracheal or bronchial foreign bodies, the authors emphasize: -the difficulty of extraction, even in very expert hands. -the absolute necessity of a fully trained operator, and experienced anaesthe... | [
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PMID:11729 | [Extraction of intrabronchial foreign bodies in young patients in a surgical unit]. | The authors report a study of 35 cases of intra-bronchial foreign bodies in young subjects (average age 6 years). This shows that, more than the age of the child, or the duration of the presence of the object, its nature, has an influence on the possibilities of extraction by bronchoscopy or by thoracotomy. Whatever th... | [Extraction of intrabronchial foreign bodies in young patients in a surgical unit]. The authors report a study of 35 cases of intra-bronchial foreign bodies in young subjects (average age 6 years). This shows that, more than the age of the child, or the duration of the presence of the object, its nature, has an influen... | [
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PMID:11730 | Glucose and insulin responses in sheep subjected to a second episode of hemorrhagic shock. | These studies indicated that the responses of the sheep beta cell parallel mnay of those seen in man. Regulation by pH, potassium, and epinephrine and suggested, as is the existence of a two-pool system for insulin synthesis and release which is responsive to glucose. Differences in glucose and insulin responses follow... | Glucose and insulin responses in sheep subjected to a second episode of hemorrhagic shock. These studies indicated that the responses of the sheep beta cell parallel mnay of those seen in man. Regulation by pH, potassium, and epinephrine and suggested, as is the existence of a two-pool system for insulin synthesis and ... | [
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PMID:11731 | Chemical mediation in Coelenterata. | This paper reports the results of a pharmacological survey of drug action on muscle preparations of the anthozoan Bunodosoma caissarum. A critical review of previous results of drug action on Coelenterate neuromuscular junction is also given. The preparations responded only to body wall homogenates and acetylcholine. S... | Chemical mediation in Coelenterata. This paper reports the results of a pharmacological survey of drug action on muscle preparations of the anthozoan Bunodosoma caissarum. A critical review of previous results of drug action on Coelenterate neuromuscular junction is also given. The preparations responded only to body w... | [
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PMID:11735 | Studies on the carbohydrate metabolism in psoriatic epidermis. | Enzymic activities and cofactor levels in the epidermis are reviewed with special regard to psoriasis and the papulosquamous disorders lichen simplex and lichen planus. The metabolism of nicotinamide adenine dinucleotide phosphate and its dependent pathways seems to deviate in psoriasis from that in the contrasted derm... | Studies on the carbohydrate metabolism in psoriatic epidermis. Enzymic activities and cofactor levels in the epidermis are reviewed with special regard to psoriasis and the papulosquamous disorders lichen simplex and lichen planus. The metabolism of nicotinamide adenine dinucleotide phosphate and its dependent pathways... | [
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PMID:11736 | [Carbohydrate and pyruvic acid degradation pathways in Fusidium coccineum strains with varying levels of antibiotic synthesis]. | A number of enzymes and reactions of glycolysis, pentose-phosphate cycle and degradation of pyruvic acid in strains of F. coccineum with various levels of antibiotic production was studied comparatively. The experiments showed that highly productive strains were characterized by higher activity of the NADP-deficient en... | [Carbohydrate and pyruvic acid degradation pathways in Fusidium coccineum strains with varying levels of antibiotic synthesis]. A number of enzymes and reactions of glycolysis, pentose-phosphate cycle and degradation of pyruvic acid in strains of F. coccineum with various levels of antibiotic production was studied com... | [
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PMID:11737 | [Dependence of erythromycin biosynthesis on the active acidity of the medium]. | Dependence of erythromycin biosynthesis on the medium active acidity was studied by the following methods: by changing pH of the initial medium, by changing the concentration of the medium components determining the active acidity of the culture, by using buffer mixtures by automatic control of pH. It was found that pH... | [Dependence of erythromycin biosynthesis on the active acidity of the medium]. Dependence of erythromycin biosynthesis on the medium active acidity was studied by the following methods: by changing pH of the initial medium, by changing the concentration of the medium components determining the active acidity of the cul... | [
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PMID:11738 | [Determination of rifamycin B activity in culture liquids and in preparations with varying degrees of purity]. | A possibility of using the biological method of rifamycin B activity determination in the fermentation broth and dry preparations of various purity levels was studied. It was found that the biological method was useful only for determination of rifamycin B activity in preparations containing not less than 850 gamma/mg ... | [Determination of rifamycin B activity in culture liquids and in preparations with varying degrees of purity]. A possibility of using the biological method of rifamycin B activity determination in the fermentation broth and dry preparations of various purity levels was studied. It was found that the biological method w... | [
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PMID:11739 | [Stability of 6-beta-[(hexahydro-1H-azepin-l-yl)methyleneamino]-penicillanic acid in aqueous solutions]. | Stability of acqueous solutions of 6-beta-[(hexahydro-IH-azepin-I-yl)methylenamino] penicillanic acid at various values of pH and temperature was studied. It was found that inactivation of the antibiotic in both the acid and the alkaline medium proceeded according to the equation of the 1st order. At pH 1.3 and a tempe... | [Stability of 6-beta-[(hexahydro-1H-azepin-l-yl)methyleneamino]-penicillanic acid in aqueous solutions]. Stability of acqueous solutions of 6-beta-[(hexahydro-IH-azepin-I-yl)methylenamino] penicillanic acid at various values of pH and temperature was studied. It was found that inactivation of the antibiotic in both the... | [
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PMID:11740 | [Interaction of morphocycline with beryllium ions]. | Behaviour of morphocycline (H5R) and its complex with beryllium ions in acqueous solutions was studied fluorimetrically. The ionization constants of H5R were estimated at pH 1.5-15 according to the data of fluorimetric determination with respect to OH-group: pK1 6.40, pK2 8.25, pK3 10.65, pK4 11.30. Two constants chara... | [Interaction of morphocycline with beryllium ions]. Behaviour of morphocycline (H5R) and its complex with beryllium ions in acqueous solutions was studied fluorimetrically. The ionization constants of H5R were estimated at pH 1.5-15 according to the data of fluorimetric determination with respect to OH-group: pK1 6.40,... | [
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PMID:11741 | [Dependence of the mutagenic effect of N-nitroso-N-methylbiuret on the pH index]. | The mutagenic effect of nitrosocompounds is known to be dependent on pH. The effect of N-nitrozo-N-methylbiuret on the conidia of Penicillium chrysogenum was studied within the ranges of pH from 5.0 to 7.0, the role of the buffer and distilled water being also considered. It was found that survival, morphological varia... | [Dependence of the mutagenic effect of N-nitroso-N-methylbiuret on the pH index]. The mutagenic effect of nitrosocompounds is known to be dependent on pH. The effect of N-nitrozo-N-methylbiuret on the conidia of Penicillium chrysogenum was studied within the ranges of pH from 5.0 to 7.0, the role of the buffer and dist... | [
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PMID:11743 | Initial fast reaction of bromine on reovirus in turbulent flowing water. | An apparatus is described for precise observation of the kinetics of the initial fast reaction of bromine with reovirus in turbulent flowing water. When quantitative electron microscopy shows that virus suspensions are essentially all single particles, the loss of infectivity follows first-order kinetics, the plaque ti... | Initial fast reaction of bromine on reovirus in turbulent flowing water. An apparatus is described for precise observation of the kinetics of the initial fast reaction of bromine with reovirus in turbulent flowing water. When quantitative electron microscopy shows that virus suspensions are essentially all single parti... | [
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PMID:11744 | Synthesis of staphylococcal enterotoxin A and nuclease under controlled fermentor conditions. | The production of enterotoxin A and nuclease by Staphylococcus aureus strain 100 was studied in a 1.0-liter fermentor. The effects of the gas flow rate, pH, and dissolved oxygen were evaluated. Toxin and nuclease secretion occurred under all conditions which permitted growth of the organism. Final yields of toxin and n... | Synthesis of staphylococcal enterotoxin A and nuclease under controlled fermentor conditions. The production of enterotoxin A and nuclease by Staphylococcus aureus strain 100 was studied in a 1.0-liter fermentor. The effects of the gas flow rate, pH, and dissolved oxygen were evaluated. Toxin and nuclease secretion occ... | [
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PMID:11745 | Inactivation by bromine of single poliovirus particles in water. | Quantitative electron microscopy shows that Freon-extracted poliovirus, velocity banded in a sucrose gradient, contains over 95% single particles. This well-dispersed virus reacts quite rapidly with bromine in turbulent flowing water, losing plaque titer at the rate of one log10 unit in 10s at pH 7, 2 C, and at a bromi... | Inactivation by bromine of single poliovirus particles in water. Quantitative electron microscopy shows that Freon-extracted poliovirus, velocity banded in a sucrose gradient, contains over 95% single particles. This well-dispersed virus reacts quite rapidly with bromine in turbulent flowing water, losing plaque titer ... | [
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PMID:11753 | Osmolar relation between cerebrospinal fluid and serum in hyperosmolar hypernatraemic dehydration. | The relation between cerebrospinal fluid (CSF) and serum osmolality was studied in 16 patients with hyperosmolar hypernatraemic dehydration before treatment. After correcting shock and acidosis, 0-45% saline in 2-5 or 5% dextrose was infused in each patient over a 48- to 72-hour period. During rehydration, serum osmola... | Osmolar relation between cerebrospinal fluid and serum in hyperosmolar hypernatraemic dehydration. The relation between cerebrospinal fluid (CSF) and serum osmolality was studied in 16 patients with hyperosmolar hypernatraemic dehydration before treatment. After correcting shock and acidosis, 0-45% saline in 2-5 or 5% ... | [
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PMID:11754 | Changes in the interstitial fluid and the muscle water in rabbits in hemorrhagic shock. | Dynamics and changes in the biochemical composition in the interstitial fluid and the muscle water were studied in hemorrhagic shock. The interstitial fluid was collected from implanted perforated capsules. Muscle biopsies were examined with regard to their water content by the steady state magnetic nuclear resonance s... | Changes in the interstitial fluid and the muscle water in rabbits in hemorrhagic shock. Dynamics and changes in the biochemical composition in the interstitial fluid and the muscle water were studied in hemorrhagic shock. The interstitial fluid was collected from implanted perforated capsules. Muscle biopsies were exam... | [
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PMID:11755 | Cardiac function and metabolism following hemorrhage in the newborn lamb. | Cardiac performance was assessed in 33 lambs less than 1 to 5 days of age by means of left ventricular function curves. Performance was quantified by determining stroke volume ejected at end diastolic pressure 10 cm H2O (SV10) with constant afterload. Coronary flow, myocardial O2 consumption (MVO2), blood gas tensions ... | Cardiac function and metabolism following hemorrhage in the newborn lamb. Cardiac performance was assessed in 33 lambs less than 1 to 5 days of age by means of left ventricular function curves. Performance was quantified by determining stroke volume ejected at end diastolic pressure 10 cm H2O (SV10) with constant after... | [
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PMID:11757 | Structure-activity relationship studies of derivatives of aminotetralins and open chain analogs in relation to beta and alpha-adrenoceptor agonist activities. | Some derivatives of aminotetralins and their open chain analogs were tested for their ability to alter blood pressure and heart rate in anesthetized cats with both vagi nerves sectioned and their ability to relax tracheal smooth muscle of guinea-pigs. TL-257 and JOD-213, tertiary amines, produced weak alpha-adrenocepto... | Structure-activity relationship studies of derivatives of aminotetralins and open chain analogs in relation to beta and alpha-adrenoceptor agonist activities. Some derivatives of aminotetralins and their open chain analogs were tested for their ability to alter blood pressure and heart rate in anesthetized cats with bo... | [
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PMID:11758 | Appetite stimulant activity of 3-carboxy-10,11-dihydrocyproheptadine. | The orexigenic and ancillary pharmacologic properties of 3-carboxy-10,11-dihydrocyproheptadine (CDC) were compared to those of cyproheptadine. The threshold dose, 0.0312 mg/kg p.o., of CDC for increasing food intake in the cat is similar to that of cyproheptadine, but CDC has a broader effective dose range, extending t... | Appetite stimulant activity of 3-carboxy-10,11-dihydrocyproheptadine. The orexigenic and ancillary pharmacologic properties of 3-carboxy-10,11-dihydrocyproheptadine (CDC) were compared to those of cyproheptadine. The threshold dose, 0.0312 mg/kg p.o., of CDC for increasing food intake in the cat is similar to that of c... | [
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PMID:11759 | Spectral density analysis of the effects of barbiturates and benzodiazepines on the electrocorticogram of the squirrel monkey. | The effects of pentobarbital and diazepam were compared in a series of tests in squirrel monkeys; the effects of phenobarbital and flurazepam were compared in a second series. Observations were made of gross behavior and on the ECoG; the latter was analyzed by the spectral density technique. The two barbiturates induce... | Spectral density analysis of the effects of barbiturates and benzodiazepines on the electrocorticogram of the squirrel monkey. The effects of pentobarbital and diazepam were compared in a series of tests in squirrel monkeys; the effects of phenobarbital and flurazepam were compared in a second series. Observations were... | [
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PMID:11760 | Very high dose fluphenazine decanoate: a controlled trial in chronic schizophrenia. | In a double-blind trial of six months' duration, a very high dose (VHD) regimen of fluphenazine decanoate (250 mg weekly) was compared with a standard dose (SD) regimen (12.5 mg weekly) in 50 chronic schizophrenic patients. The rating scales used included the Brief Psychiatric Rating Scale and the Wing Ward Behavior Sc... | Very high dose fluphenazine decanoate: a controlled trial in chronic schizophrenia. In a double-blind trial of six months' duration, a very high dose (VHD) regimen of fluphenazine decanoate (250 mg weekly) was compared with a standard dose (SD) regimen (12.5 mg weekly) in 50 chronic schizophrenic patients. The rating s... | [
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PMID:11761 | Effect of adrenergic blockade on gastric secretion altered by catecholamines in rats. | The effect of adrenergic blockade on gastric secretion altered by catecholamines was studied for 4 hr after injection in rats with chronic gastric fistulas. The alpha-adrenergic blockers phenoxybenzamine and phentolamine significantly inhibited the basal secretion of HCl and pepsin. Blockade of the beta-adrenergic rece... | Effect of adrenergic blockade on gastric secretion altered by catecholamines in rats. The effect of adrenergic blockade on gastric secretion altered by catecholamines was studied for 4 hr after injection in rats with chronic gastric fistulas. The alpha-adrenergic blockers phenoxybenzamine and phentolamine significantly... | [
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PMID:11762 | Fluctuation in activity of the molecular forms of cellular DNA polymerase during infection by SV40. | Infection of BSC-1 cells by SV40 brings about an increase of 7--11-fold in DNA polymerase activity, found in the nuclei and cytoplasm, respectively. The overall ratio between activites of DNA polymerase beta (3.1S) and DNA polymerase alpha (5.5S) remains fairly constant throughout infection. However,there is a large in... | Fluctuation in activity of the molecular forms of cellular DNA polymerase during infection by SV40. Infection of BSC-1 cells by SV40 brings about an increase of 7--11-fold in DNA polymerase activity, found in the nuclei and cytoplasm, respectively. The overall ratio between activites of DNA polymerase beta (3.1S) and D... | [
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PMID:11763 | pH mediated inhibition of the cell to cell spread of herpes simplex virus infection. | The relationships between the environmental pH and the replication and spread of herps simplex virus (HSV) infection in rabbit skin (RS) cell cultures was studies. Relative to the plaque formation at pH7.0, incubation of RS cells with medium adjusted to pH 6.6 resulted in a 50 to 70 per cent decrement in plaque number.... | pH mediated inhibition of the cell to cell spread of herpes simplex virus infection. The relationships between the environmental pH and the replication and spread of herps simplex virus (HSV) infection in rabbit skin (RS) cell cultures was studies. Relative to the plaque formation at pH7.0, incubation of RS cells with ... | [
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PMID:11764 | The infection of cucumber mesophyll protoplasts with tobacco mosaic virus. | Protoplasts from the first leaf mesophyll of cucumber plants were isolated by an 18 hours combined petinase/cellulase treatment. Conditions favouring the infection of these protoplasts with tobacco mosaic virus (TMV), and the accumulation of infective virus up to 96 hours after inoculation have been studied. Infection ... | The infection of cucumber mesophyll protoplasts with tobacco mosaic virus. Protoplasts from the first leaf mesophyll of cucumber plants were isolated by an 18 hours combined petinase/cellulase treatment. Conditions favouring the infection of these protoplasts with tobacco mosaic virus (TMV), and the accumulation of inf... | [
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PMID:11765 | The growth of respiratory syncytial virus in organ cultures of bovine foetal trachea. | Respiratory syncytial (RS) virus grown in organ cultures of bovine foetal trachea at 37 degrees C and pH 7.2 reached maximum titres of up to 1 X 10(5) PFU/ml between 11 and 21 days after inoculation. Virus yield was increased three fold by incubation at 33 degrees C, but depressed by the addition of RS virus antiserum,... | The growth of respiratory syncytial virus in organ cultures of bovine foetal trachea. Respiratory syncytial (RS) virus grown in organ cultures of bovine foetal trachea at 37 degrees C and pH 7.2 reached maximum titres of up to 1 X 10(5) PFU/ml between 11 and 21 days after inoculation. Virus yield was increased three fo... | [
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PMID:11767 | Epilepsy. | Epilepsy is a common disorder affecting approximately one in every two hundred people, from all walks of life, and presenting in addition to the seizure disorder itself, varying social, psychological and economic problems. A simple classification of epilepsy is described, and the concept of 'seizure threshold' introduc... | Epilepsy. Epilepsy is a common disorder affecting approximately one in every two hundred people, from all walks of life, and presenting in addition to the seizure disorder itself, varying social, psychological and economic problems. A simple classification of epilepsy is described, and the concept of 'seizure threshold... | [
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PMID:11771 | Rate of elemental sulfur oxidation in some soils of Egypt as affected by the salinity level, moisture, texture, temperature and inoculation. | 1. The level of soil moisture most favourable to the oxidation of elemental sulfur was found to be around the field moisture capacity; the oxidation rate decreased at lower and higher moisture levels. 2. The rate of oxidation increased with the clay content of the soils from sandy loam to clay loam. 3. Although S-oxida... | Rate of elemental sulfur oxidation in some soils of Egypt as affected by the salinity level, moisture, texture, temperature and inoculation. 1. The level of soil moisture most favourable to the oxidation of elemental sulfur was found to be around the field moisture capacity; the oxidation rate decreased at lower and hi... | [
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PMID:11772 | Concentration of MgATP2- and other ions in solution. Calculation of the true concentrations of species present in mixtures of associating ions. | 1. A simple method is described for calculating the free concentrations of all species in a mixture of several ionic components that associate at equilibrium to any extent and with any stoicheiometry. 2. It can readily be adapted to take account of species such as protons for which the free rather than the total concen... | Concentration of MgATP2- and other ions in solution. Calculation of the true concentrations of species present in mixtures of associating ions. 1. A simple method is described for calculating the free concentrations of all species in a mixture of several ionic components that associate at equilibrium to any extent and ... | [
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PMID:11773 | Purification and properties of arylsulphatase A from rabbit testis. | Rabbit testis arylsulphatase A was purified 140-fold with a recovery of 20% from detergent extracts of an acetone-dried powder by using DE-52 cellulose column chromatography, gel filtration on Sephadex G-200 and preparative isoelectric focusing. The purified enzyme showed one major band with one minor contaminant on el... | Purification and properties of arylsulphatase A from rabbit testis. Rabbit testis arylsulphatase A was purified 140-fold with a recovery of 20% from detergent extracts of an acetone-dried powder by using DE-52 cellulose column chromatography, gel filtration on Sephadex G-200 and preparative isoelectric focusing. The pu... | [
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PMID:11774 | Application of a spectrophotometric method to the determination of the composition of oligonucleotides obtained from cysteine transfer ribonucleic acid. | 1. The applications of methods for determining the composition of oligonucleotides from u.v.-absorption spectra is described. 2. In the first method absorbances at selected wave-lengths were read from the spectra of oligonucleotides in solution in 7 M-urea which had been recorded at acid and alkaline pH values. 3. In t... | Application of a spectrophotometric method to the determination of the composition of oligonucleotides obtained from cysteine transfer ribonucleic acid. 1. The applications of methods for determining the composition of oligonucleotides from u.v.-absorption spectra is described. 2. In the first method absorbances at sel... | [
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PMID:11775 | Unmasking of histone amino groups in chromatin at high pH. | The reactivity of the amino groups of histones in chromatin towards acetic anhydride was determined as a function of pH. In the pH range 7-10 the vast majority of amino groups in all five histones are buried. However, at higher pH values some of the histone amino groups become exposed, and the higher the lysine:arginin... | Unmasking of histone amino groups in chromatin at high pH. The reactivity of the amino groups of histones in chromatin towards acetic anhydride was determined as a function of pH. In the pH range 7-10 the vast majority of amino groups in all five histones are buried. However, at higher pH values some of the histone ami... | [
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PMID:11776 | Isolation, characterization and oxygen equilibrium of an extracellular haemoglobin from Eunice aphroditois (Passas). | The extracellular haemoglobin from the polychaeta,Eunice aphroditois, existed as a mixture of a heavy major component (so20, w = 56.96 +/- 0.125) and a light minor component (so20, w = 10.00 +/- 0.13S), the latter probably being a dissociation product of the former. The molecular weight of the purified heavier componen... | Isolation, characterization and oxygen equilibrium of an extracellular haemoglobin from Eunice aphroditois (Passas). The extracellular haemoglobin from the polychaeta,Eunice aphroditois, existed as a mixture of a heavy major component (so20, w = 56.96 +/- 0.125) and a light minor component (so20, w = 10.00 +/- 0.13S), ... | [
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PMID:11777 | Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe. | 1. Fully active ficin (EC 3.4.22.3) containing 1 mol of thiol with high reactivity towards 2,2'-dipyridyl disulphide (2-Py-S-S-2-Py) at pH4.5 per mol of protein was prepared from the dried latex of Ficus glabrata by covalent chromatography on a Sepharose-glutathione-2-pyridyl disulphide gel. 2. Ficin thus prepared is a... | Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe. 1. Fully active ficin (EC 3.4.22.3) containing 1 mol of thiol with high reactivity towards 2,2'-dipyridyl disulphide (2-Py-S-S-2-Py) at pH4... | [
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PMID:11778 | 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole as a reactivity probe for the investigation of the thiol proteinases. evidence that ficin and bromelain may lack carboxyl groups conformationally equivalent to that of aspartic acid-158 of papain. | 1. 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (Nbd chloride) was used as a reactivity probe to characterize the active centres of papin (EC 3.4.22.2), ficin (EC 3.4.22.3) and bromelain (EC 3.4.22.4). 2. In the pH range 0-8 Nbd chloride probably exists mainly as a monocation, possibly with the proton located on N-1 of the ... | 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole as a reactivity probe for the investigation of the thiol proteinases. evidence that ficin and bromelain may lack carboxyl groups conformationally equivalent to that of aspartic acid-158 of papain. 1. 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (Nbd chloride) was used as a reactivity ... | [
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PMID:11779 | A convenient method of preparation of high-activity urease from Canavalia ensiformis by covalent chromatography and an investigation of its thiol groups with 2,2'-dipyridyl disulphide as a thiol titrant and reactivity probe. | 1. A convenient method of preparation of jack-bean urease (EC3.5.1.5) involving covalent chromatography by thiol-disulphide interchange is described. 2. Urease thus prepared has specific activity comparable with the highest value yet reported (44.5 +/- 1.47 kat/kg, Km = 3.32 +/- 0.05 mM; kcat. = 2.15 X 10(4) +/- 0.05 X... | A convenient method of preparation of high-activity urease from Canavalia ensiformis by covalent chromatography and an investigation of its thiol groups with 2,2'-dipyridyl disulphide as a thiol titrant and reactivity probe. 1. A convenient method of preparation of jack-bean urease (EC3.5.1.5) involving covalent chroma... | [
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PMID:11780 | Isolation and characterization of two sequence-specific endonucleases from Anabaena variabilis. | Two endonucleases, AvaI and AvaII, were isolated from Anabaena variabilis on the basis of their ability to make a limited number of breaks at specific points in bacteriophage lambda DNA. Neither enzyme has cofactor requirements beyond Mg2+. Endonuclease AvaI makes eight breaks in the phage lambda chromosome at which th... | Isolation and characterization of two sequence-specific endonucleases from Anabaena variabilis. Two endonucleases, AvaI and AvaII, were isolated from Anabaena variabilis on the basis of their ability to make a limited number of breaks at specific points in bacteriophage lambda DNA. Neither enzyme has cofactor requireme... | [
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PMID:11781 | Absorption of antisera for studies on specific enzyme turnover. | Antisera were raised to acetyl-CoA carboxylase and 6-phosphogluconate dehydrogenase from mammary glands of lactating rabbits, and cytochrome oxidase from rat liver. The enzymes were all highly purified but gave rise to multispecific antisera when tested against tissue extracts. Absorption procedures were devised to fre... | Absorption of antisera for studies on specific enzyme turnover. Antisera were raised to acetyl-CoA carboxylase and 6-phosphogluconate dehydrogenase from mammary glands of lactating rabbits, and cytochrome oxidase from rat liver. The enzymes were all highly purified but gave rise to multispecific antisera when tested ag... | [
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PMID:11782 | The kinetics and mechanism of the recombination reaction between apomyoglobin and haemin. | A simple rapid-mixing technique is described which allows the recombination reaction between apomyoglobin and haemin to be studied within 0.3s of the splitting of myoglobin by dilute HCl. Evidence is presented that indicates that the recombination process occurs between folded 'native' apomyoglobin and monomeric haemin... | The kinetics and mechanism of the recombination reaction between apomyoglobin and haemin. A simple rapid-mixing technique is described which allows the recombination reaction between apomyoglobin and haemin to be studied within 0.3s of the splitting of myoglobin by dilute HCl. Evidence is presented that indicates that ... | [
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PMID:11783 | Thiol-protein disulphide oxidoreductases. Assay of microsomal membrane-bound glutathione-insulin transhydrogenase and comparison with protein disulphide-isomerase. | 1. Inhibition of endogenous microsomal NADPH oxidase by CO enables membrane-bound glutathione-insulin transhydrogenase (EC 1.8.4.2) to be assayed conveniently by a linked assay involving NADPH and glutathione reductase (EC 1.6.4.2). 2. The specific activity of the enzyme in rat liver microsomal preparations is of the o... | Thiol-protein disulphide oxidoreductases. Assay of microsomal membrane-bound glutathione-insulin transhydrogenase and comparison with protein disulphide-isomerase. 1. Inhibition of endogenous microsomal NADPH oxidase by CO enables membrane-bound glutathione-insulin transhydrogenase (EC 1.8.4.2) to be assayed convenient... | [
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PMID:11784 | Adenosine 3':5'-cyclic monophosphate-binding proteins in bovine and rat tissues. | 1. At least two classes of high-affinity cyclic AMP-binding proteins have been identified: those derived from cyclic AMP-dependent protein kinases (regulatory subunits) and those that bind a wide range of adenine analogues (adenine analogue-binding proteins). 2. In fresh-tissue extracts, regulatory subunits could be fu... | Adenosine 3':5'-cyclic monophosphate-binding proteins in bovine and rat tissues. 1. At least two classes of high-affinity cyclic AMP-binding proteins have been identified: those derived from cyclic AMP-dependent protein kinases (regulatory subunits) and those that bind a wide range of adenine analogues (adenine analogu... | [
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PMID:11808 | Hypotensive and antiarrhythmic effects of a new alkaloid, the 13-hydroxylupanine-2-pyrrolcarbonic acid ester, from the Madagascan plant Cadia ellisiana. | The alkaloid 13-hydroxylupanine-2-pyrrolcarbonic acid ester (Hoe 933) from the Madagascan plant Cadia ellisiana has an hypotensive and antiarrhythmic effect. The hypotensive effect in dogs, monkeys, and rats anaesthetized with barbiturates reaches its maximum with 0.2 mg/kg i.v. However, the hypotensive effect is much ... | Hypotensive and antiarrhythmic effects of a new alkaloid, the 13-hydroxylupanine-2-pyrrolcarbonic acid ester, from the Madagascan plant Cadia ellisiana. The alkaloid 13-hydroxylupanine-2-pyrrolcarbonic acid ester (Hoe 933) from the Madagascan plant Cadia ellisiana has an hypotensive and antiarrhythmic effect. The hypot... | [
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PMID:11809 | The action of psychotropic drugs on DOPA induced behavioural responses in mice. | The "DOPA potentiation" test in mice was investigated for its usefulness in the detection of compounds with antidepressant properties. It was found that the anti-depressant drugs imipramine, amitriptyline, 5-methylamino-acetyl-6-methyl-5,6-dihydro-phenanthridine-HCl (Org OI77) and 1,2,3,4,10,14b-hexahydro-2-methyl-dibe... | The action of psychotropic drugs on DOPA induced behavioural responses in mice. The "DOPA potentiation" test in mice was investigated for its usefulness in the detection of compounds with antidepressant properties. It was found that the anti-depressant drugs imipramine, amitriptyline, 5-methylamino-acetyl-6-methyl-5,6-... | [
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PMID:11810 | Investigation of phosphatidylethanolamine bilayers by deuterium and phosphorus-31 nuclear magnetic resonance. | The motion of the ethanolamine head group in unsonicated lipid bilayers above and below the phase transition is studied by means of deuterium and phosphorus magnetic resonance. For this purpose, dipalmitoyl-3-sn-phosphatidylethanolamine is selectively deuterated at the two ethanolamine carbon atoms. The deuterium quadr... | Investigation of phosphatidylethanolamine bilayers by deuterium and phosphorus-31 nuclear magnetic resonance. The motion of the ethanolamine head group in unsonicated lipid bilayers above and below the phase transition is studied by means of deuterium and phosphorus magnetic resonance. For this purpose, dipalmitoyl-3-s... | [
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PMID:11811 | Fluorine-containing analogues of intermediates in the Shikimate pathway. | The phosphoenolpyruvate analogue (Z)-phosphoenol-3-fluoropyruvate is a substrate for phenylalanine-inhibitable 3-deoxy-D-arabino-heptulosonic acid-7-phosphate synthase from Escherichia coli. In the presence of excess erythrose 4-phosphate, apparent KM values of 65 and 38 muM were observed for phosphoenol-3-fluoropyruva... | Fluorine-containing analogues of intermediates in the Shikimate pathway. The phosphoenolpyruvate analogue (Z)-phosphoenol-3-fluoropyruvate is a substrate for phenylalanine-inhibitable 3-deoxy-D-arabino-heptulosonic acid-7-phosphate synthase from Escherichia coli. In the presence of excess erythrose 4-phosphate, apparen... | [
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PMID:11812 | Characterization of the recombination reaction of rhodopsin. | The kinetics of recombination of 11-cis-retinal with bleached rod outer segments and sodium cholate solubilized rhodopsin have been investigated. At neutral pH, it was found that bleached rod outer segments in the presence of an excess of 11-cis-retinal follow pseudo-first-order kinetics. The results suggest the second... | Characterization of the recombination reaction of rhodopsin. The kinetics of recombination of 11-cis-retinal with bleached rod outer segments and sodium cholate solubilized rhodopsin have been investigated. At neutral pH, it was found that bleached rod outer segments in the presence of an excess of 11-cis-retinal follo... | [
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PMID:11815 | Energy tranduction in photosynthetic bacteria. XI. Further resolution of cytochromes of b type and the nature of the co-sensitive oxidase present in the respiratory chain of Rhodopseudomonas capsulata. | 1. In membranes prepared from dark grown cells of Rhodopseudomonas capsulata, five cytochromes of b type (E'0 at pH 7.0 +413+/-5, +270+/-5, +148+/-5, +56+/-5 and -32+/-5 mV) can be detected by redox titrations at different pH values. The midpoint potentials of only three of these cytochromes (b148, b56, and b-32) vary ... | Energy tranduction in photosynthetic bacteria. XI. Further resolution of cytochromes of b type and the nature of the co-sensitive oxidase present in the respiratory chain of Rhodopseudomonas capsulata. 1. In membranes prepared from dark grown cells of Rhodopseudomonas capsulata, five cytochromes of b type (E'0 at pH 7.... | [
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PMID:11816 | Light-dependent changes of the Mg2+ concentration in the stroma in relation to the Mg2+ dependency of CO2 fixation in intact chloroplasts. | (1) Light-dependent changes of the Mg2+ content of thylakoid membranes were measured at pH 8.0 and compared with earlier measurements at pH 6.6. In a NaCl and KCl medium, the light-dependent decrease in the Mg2+ content of the thylakoid membranes at pH 8.0 is found to be 23 nmol Mg2+ per mg chlorophyll, whereas in a so... | Light-dependent changes of the Mg2+ concentration in the stroma in relation to the Mg2+ dependency of CO2 fixation in intact chloroplasts. (1) Light-dependent changes of the Mg2+ content of thylakoid membranes were measured at pH 8.0 and compared with earlier measurements at pH 6.6. In a NaCl and KCl medium, the light-... | [
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PMID:11817 | Studies on the ferrochelatase activity of isolated rat liver mitochondria with special reference to the effect of oxidizable substrates and oxygen concentration. | The mitochondrial ferrochelatase activity has been studied in coupled rat liver mitochondria using deuteroporphyrin IX (incorporated into liposomes of lecithin) and Fe(III) or Co(II) as the substrates. 1. It was found that respiring mitochondria catalyze the insertion of Fe(II) and Co(II) into deuteroporphyrin. When Fe... | Studies on the ferrochelatase activity of isolated rat liver mitochondria with special reference to the effect of oxidizable substrates and oxygen concentration. The mitochondrial ferrochelatase activity has been studied in coupled rat liver mitochondria using deuteroporphyrin IX (incorporated into liposomes of lecithi... | [
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PMID:11818 | Photoinactivation of photophosphorylation and dark ATPase in Rhodospirillum rubrum chromatophores. | Preillumination of Rhodospirillum rubrum chromatophores with strong, far-red light in the presence of phenazine methosulfate under non-phosphorylation conditions results in a selective, irreversible inactivation (typically about 70%) of photophosphorylation and of uncoupler-stimulated dark ATPase. The time course of th... | Photoinactivation of photophosphorylation and dark ATPase in Rhodospirillum rubrum chromatophores. Preillumination of Rhodospirillum rubrum chromatophores with strong, far-red light in the presence of phenazine methosulfate under non-phosphorylation conditions results in a selective, irreversible inactivation (typicall... | [
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PMID:11819 | Control of synbiotic nitrogen fixation in Rhizobia. Regulation of NH4+ assimilation. | This communication is concerned with physiological, biochemical, and genetic studies of the regulation of ammonium (NH4+) assimilation by Rhizobia (root nodule bacteria) that infect leguminous plants. The major conclutions are (i) physiological studies show that Rhizobia are able to assimilate NH4+ for growth only when... | Control of synbiotic nitrogen fixation in Rhizobia. Regulation of NH4+ assimilation. This communication is concerned with physiological, biochemical, and genetic studies of the regulation of ammonium (NH4+) assimilation by Rhizobia (root nodule bacteria) that infect leguminous plants. The major conclutions are (i) phys... | [
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PMID:11821 | Conformational dependence on pH in tripeptides. | From the 1H-NMR study of Tyr-Gly-Gly and Phe-Gly-Gly in H2O and 2H2O as a function of pH it follows that these tripeptides display at least two and probably three conformational zones. Under slow exchange conditions of the peptidic NH-protons, coupling constants 3J(NH, CaH) may be extracted as the probe. At higher pH v... | Conformational dependence on pH in tripeptides. From the 1H-NMR study of Tyr-Gly-Gly and Phe-Gly-Gly in H2O and 2H2O as a function of pH it follows that these tripeptides display at least two and probably three conformational zones. Under slow exchange conditions of the peptidic NH-protons, coupling constants 3J(NH, Ca... | [
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PMID:11822 | Inactivation of Streptomyces subtilisin inhibitory by chemical modifications. | 1. The inhibitory activity of an alkaline protease inhibitor, (Streptomyces subtilisin inhibitor) towards subtilisin is found to decrease by photooxidation sensitized by methylene blue with a clear pH dependence, the midpoint of which is about 6.0. 2. Amino acid analyses of photooxidized Streptomyces subtilisin inhibit... | Inactivation of Streptomyces subtilisin inhibitory by chemical modifications. 1. The inhibitory activity of an alkaline protease inhibitor, (Streptomyces subtilisin inhibitor) towards subtilisin is found to decrease by photooxidation sensitized by methylene blue with a clear pH dependence, the midpoint of which is abou... | [
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PMID:11823 | Use of an iridium electrode for direct measurements of pI of proteins after isoelectric focusing in polyacrylamide gel. | The use of an iridium microelectrode 0.5 mm in diameter is proposed for measuring the pH gradient in polyacrylamide gels after isoelectric focusing. The electrode exhibits a perfectly linear potential/pH relationship; thus it can be used directly in conjunction with a pH meter using the pH scale for readings. pH equili... | Use of an iridium electrode for direct measurements of pI of proteins after isoelectric focusing in polyacrylamide gel. The use of an iridium microelectrode 0.5 mm in diameter is proposed for measuring the pH gradient in polyacrylamide gels after isoelectric focusing. The electrode exhibits a perfectly linear potential... | [
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PMID:11824 | Fluorescence properties of 2' (or 3')-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate and its use in the study of binding to heavy meromyosin ATPase. | 2' (or 3')-O-(2,4,6-Trinitrophenyl) adenosine 5'-triphosphate (N3ph-ATP), which contains a Meisenheimer complex moiety, is one of the class of compounds which do not fluoresce in water but fluoresce both in low polarity solvents and when bound to the protein molecule. Fluorescence intensity of N3ph-ATP in the range of ... | Fluorescence properties of 2' (or 3')-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate and its use in the study of binding to heavy meromyosin ATPase. 2' (or 3')-O-(2,4,6-Trinitrophenyl) adenosine 5'-triphosphate (N3ph-ATP), which contains a Meisenheimer complex moiety, is one of the class of compounds which do not f... | [
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PMID:11825 | Purification and characterization of a coagulant protein from the venom of Russell's viper. | The coagulant protein from the venom of Russell's viper was purified by means of successive chromatography on Sephadex G-50, DEAE-cellulose and Sephadex G-200. The purified coagulant protein was homogeneous by polyacrylamide gel electrophoresis and ultracentrifugation. The molecular weight was estimated to be about 100... | Purification and characterization of a coagulant protein from the venom of Russell's viper. The coagulant protein from the venom of Russell's viper was purified by means of successive chromatography on Sephadex G-50, DEAE-cellulose and Sephadex G-200. The purified coagulant protein was homogeneous by polyacrylamide gel... | [
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PMID:11826 | Competitive binding of iron by transferrins from different vertebrates. | 1. A competitive dialysis technique has been used to study the relative affinities of the two iron-binding sites on transferrin molecules and the relative binding strengths of transferrins isolated from plasma of different species. 2. The comparisons were extended to include desialylated human transferrin, ovotransferr... | Competitive binding of iron by transferrins from different vertebrates. 1. A competitive dialysis technique has been used to study the relative affinities of the two iron-binding sites on transferrin molecules and the relative binding strengths of transferrins isolated from plasma of different species. 2. The compariso... | [
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PMID:11827 | Effect of divalent metal ions on the digestibility of concanavalin A by endopeptidases. | Demetallized concanavalin A is degraded rapidly at pH 7.0 and 8.2 by alpha-chymotrypsin, thermolysin or trypsin, yielding peptide fragments devoid of ability to bind to Sephadex G-75. Addition of Ni2+ and of Ca2+ confers on concanavalin A high resistance towards proteolytic attack so that even after long periods of exp... | Effect of divalent metal ions on the digestibility of concanavalin A by endopeptidases. Demetallized concanavalin A is degraded rapidly at pH 7.0 and 8.2 by alpha-chymotrypsin, thermolysin or trypsin, yielding peptide fragments devoid of ability to bind to Sephadex G-75. Addition of Ni2+ and of Ca2+ confers on concanav... | [
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PMID:11828 | Hemoglobin Fannin-Lubbock [alpha2 beta 2 119 (GH2) Gly replaced by Asp]. A new hemoglobin variant at the alpha1 beta 1 contact. | Hemoglobin Fannin-Lubbock was found in a 9-year-old Mexican-American female. The abnormal hemoglobin was detected as a fast-moving variant by electrophoresis on cellulose acetate at pH 8.4. Structural analysis indicated a substitution in the beta-chain of aspartic acid for glycine at position 119, a position involved i... | Hemoglobin Fannin-Lubbock [alpha2 beta 2 119 (GH2) Gly replaced by Asp]. A new hemoglobin variant at the alpha1 beta 1 contact. Hemoglobin Fannin-Lubbock was found in a 9-year-old Mexican-American female. The abnormal hemoglobin was detected as a fast-moving variant by electrophoresis on cellulose acetate at pH 8.4. St... | [
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PMID:11830 | An unusual fluorescence spectrum of a protein proteinase inhibitor, Streptomyces subtilisin inhibitor. | Streptomyces subtilisin inhibitor, a dimeric protein proteinase inhibitor isolated in crystalline form by Murae et al. in 1972, contains three tyrosine and one tryptophan residues per monomer unit and has unusual fluorescence properties. When excited at 280 nm, it shows a characteristic fluorescence spectrum having a p... | An unusual fluorescence spectrum of a protein proteinase inhibitor, Streptomyces subtilisin inhibitor. Streptomyces subtilisin inhibitor, a dimeric protein proteinase inhibitor isolated in crystalline form by Murae et al. in 1972, contains three tyrosine and one tryptophan residues per monomer unit and has unusual fluo... | [
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PMID:11831 | Structure-activity relationships of luliberin substituted at position 8. | Substitution of arginine at position 8 of luliberin by the basic amino acids homoarginine, lysine and diaminobutyric acid resulted in analogues in which the luteinizing hormone-releasing activity is markedly reduced, whereas the cross reactivity with specific antibodies to luliberin is preserved. Fluorimetric titration... | Structure-activity relationships of luliberin substituted at position 8. Substitution of arginine at position 8 of luliberin by the basic amino acids homoarginine, lysine and diaminobutyric acid resulted in analogues in which the luteinizing hormone-releasing activity is markedly reduced, whereas the cross reactivity w... | [
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PMID:11832 | Purification from baker's yeast of an activator of DNA photolyase. | The activity of purified DNA photolyase from Baker's yeast is enhanced by a compound (Activator (III)) obtained from yeast by chloroform extraction ion exchange chromatography and gel filtration. Thin layer chromatography and spectral data indicate that the compound is homogeneous. Activator III emits at 350 and 440 nm... | Purification from baker's yeast of an activator of DNA photolyase. The activity of purified DNA photolyase from Baker's yeast is enhanced by a compound (Activator (III)) obtained from yeast by chloroform extraction ion exchange chromatography and gel filtration. Thin layer chromatography and spectral data indicate that... | [
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PMID:11833 | Altered leucyl-transfer RNA synthetase from a mammalian cell culture mutant. | Altered leucyl-tRNA synthetase from a mammalian cell culture temperature-sensitive mutant, tsHl, was compared with enzyme from normal wild type Chinese hamster ovary cells. The mutant enzyme had a Km for leucine four times larger than that of wild type and enzyme levels 3-10% that of wild type. The presence of tRNA was... | Altered leucyl-transfer RNA synthetase from a mammalian cell culture mutant. Altered leucyl-tRNA synthetase from a mammalian cell culture temperature-sensitive mutant, tsHl, was compared with enzyme from normal wild type Chinese hamster ovary cells. The mutant enzyme had a Km for leucine four times larger than that of ... | [
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PMID:11834 | Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells. | A pH-dependent, saturable binding of hexokinase isozyme I from Ehrlich ascites carcinoma to plasma membrane and microsome preparations from the same tissue is demonstrated. This binding is enhanced by glucose 6-phosphate and may be considered as the sum of a glucose 6-phosphate-dependent binding and an independent bind... | Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells. A pH-dependent, saturable binding of hexokinase isozyme I from Ehrlich ascites carcinoma to plasma membrane and microsome preparations from the same tissue is demonstrated. This binding is enhanced by glucose 6-phosphate and may be... | [
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PMID:11835 | Plasma membrane phosphorylation by endogenous phosphate donors in human blood platelets. Selectivity of the action of dibutyryl cyclic AMP. | Incubation of platelet-rich plasma with 32Pi leads to cellular uptake of the isotope and covalent incorporation into several cell constituents. Plasma membranes isolated from intact labelled platelets, delipidated and solubilized in sodium dodecyl sulfate, show, upon gel electorphoretic analysis, three main peaks of ra... | Plasma membrane phosphorylation by endogenous phosphate donors in human blood platelets. Selectivity of the action of dibutyryl cyclic AMP. Incubation of platelet-rich plasma with 32Pi leads to cellular uptake of the isotope and covalent incorporation into several cell constituents. Plasma membranes isolated from intac... | [
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PMID:11836 | [Purification and properties of rat kidney catechol-O-methyltransferase]. | The S-adenosyl-methionine: catechol-O-methyltransferase (EC 2.1.1.6) from rat kidney was purified about 650 fold as compared with the homogenate and the result of disc electrophoresis presented. The purification involved extraction, precipitation at pH 5, ammonium sulfate fractionation, Chromatographies on Biogel 0.5 m... | [Purification and properties of rat kidney catechol-O-methyltransferase]. The S-adenosyl-methionine: catechol-O-methyltransferase (EC 2.1.1.6) from rat kidney was purified about 650 fold as compared with the homogenate and the result of disc electrophoresis presented. The purification involved extraction, precipitation... | [
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PMID:11837 | Purification and some properties of free and cell-associated dextransucrase from Streptococcus sanguis. | Dextransucrase of Streptococcus sanguis occurred in cell-free and cell-associated forms. Cell-free dextransucrase was purified by four successive chromatographies on Bio-Gel P 60, DEAE-cellulose, and Bio-Gel P 200 from the culture supernatant. The purification of cell-associated dextransucrase was made from the pellet ... | Purification and some properties of free and cell-associated dextransucrase from Streptococcus sanguis. Dextransucrase of Streptococcus sanguis occurred in cell-free and cell-associated forms. Cell-free dextransucrase was purified by four successive chromatographies on Bio-Gel P 60, DEAE-cellulose, and Bio-Gel P 200 fr... | [
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PMID:11838 | [Primary structure of bovine erythrocyte carbonic anhydrase CI. I. Tryptic peptides]. | Bovine erythrocyte carbonic anhydrase CI consists of 259 amino acid residues including 18 lysines and 9 arginines. Its primary structure has been first investigated by isolation and sequence determination of the tryptic units. Acidification of the tryptic hydrolysate leads to the precipitation of 40% of the peptidic ma... | [Primary structure of bovine erythrocyte carbonic anhydrase CI. I. Tryptic peptides]. Bovine erythrocyte carbonic anhydrase CI consists of 259 amino acid residues including 18 lysines and 9 arginines. Its primary structure has been first investigated by isolation and sequence determination of the tryptic units. Acidifi... | [
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PMID:11839 | The shikimate pathway. III. 3-dehydroquinate synthetase of E. coli. Mechanistic studies by kinetic isotope effect. | The conversion of 3-deoxy D-arabino heptulosonate 7-phosphate to 3-dehydroquinate by the 3-dehydroquinate synthetase from E. coli is characterized by a low but significant kinetic isotope effect for tritium carried in position-5 of DAHP, while no isotope effect was detectable for tritium in position-4. This effect was ... | The shikimate pathway. III. 3-dehydroquinate synthetase of E. coli. Mechanistic studies by kinetic isotope effect. The conversion of 3-deoxy D-arabino heptulosonate 7-phosphate to 3-dehydroquinate by the 3-dehydroquinate synthetase from E. coli is characterized by a low but significant kinetic isotope effect for tritiu... | [
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PMID:11840 | [Mechanism of opiate of oxidative phosphorylation in mitochondria]. | Effect of morphine, codeine, dionine and nalorphine on the oxidative phosphorylation in rat liver mitochondria was studied. Morphine is found to inhibit both ATP-synthetase and ATP-ase activities in mitochondria, but not in submitochondrial particles. Morphine-suppressed oxidative phosphorylation was competitively reve... | [Mechanism of opiate of oxidative phosphorylation in mitochondria]. Effect of morphine, codeine, dionine and nalorphine on the oxidative phosphorylation in rat liver mitochondria was studied. Morphine is found to inhibit both ATP-synthetase and ATP-ase activities in mitochondria, but not in submitochondrial particles. ... | [
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PMID:11841 | [Regulation of urocaninase activity in the liver: role of 3',5'-AMP]. | A dependence of rat liver urocaninase activity on the agents affecting the adenylate cyclase system was studied in vitro and in vivo. Urocaninase is considerably activated after the injection of glucagone, NaF, theophylline and 3',5'-AMP. Under conditions optimal for the protein kinase activity of phosphorylase the uro... | [Regulation of urocaninase activity in the liver: role of 3',5'-AMP]. A dependence of rat liver urocaninase activity on the agents affecting the adenylate cyclase system was studied in vitro and in vivo. Urocaninase is considerably activated after the injection of glucagone, NaF, theophylline and 3',5'-AMP. Under condi... | [
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PMID:11842 | [Effect of environmental factors on inactivation of B12-dependent glycerol dehydratase from Aerobacter aerogenes]. | Effect of temperature, pH and univalent cation on kinetics of self-activation of B12-dependent glycerol dehydratase (GD) from Aerobacter aerogenes with Co alpha-[alpha-(5,6-dimethylbenzimidazolyl]-Co beta-adenosylcobamide (AdoCbl) was investigated. The activation energy of the process of GD inactivation is found to be ... | [Effect of environmental factors on inactivation of B12-dependent glycerol dehydratase from Aerobacter aerogenes]. Effect of temperature, pH and univalent cation on kinetics of self-activation of B12-dependent glycerol dehydratase (GD) from Aerobacter aerogenes with Co alpha-[alpha-(5,6-dimethylbenzimidazolyl]-Co beta-... | [
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PMID:11843 | [Regulation of glutamine metabolism in Chlorella pyrenoidosa. Mechanisms of regulating the activity of glutamine synthetase during ammonia assimilation]. | Glutamine synthetase (GS) (E.C.6.3.1.2) activity in Chlorella cells decreased when NH4+ was added to nitrogen-free growth medium. This GS inactivation had such a rate, that it could not be due to the repression of enzyme synthesis: the GS activity decreased by 20% within 5 minutes of NH4+ assimilation. Glutamine conten... | [Regulation of glutamine metabolism in Chlorella pyrenoidosa. Mechanisms of regulating the activity of glutamine synthetase during ammonia assimilation]. Glutamine synthetase (GS) (E.C.6.3.1.2) activity in Chlorella cells decreased when NH4+ was added to nitrogen-free growth medium. This GS inactivation had such a rate... | [
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PMID:11844 | [Isolation and several properties of purified preparations of the alkaline ribonuclease of the soluble fraction of rat cerebral hemispheres]. | Preparations of alkaline ribonuclease with optimum activity at pH 7,8 have been isolated from postmitochondrial fraction of the rat brain tissue by ammonium sulfate precipitation, 0.1 HCl extraction and following ammonium sulfate fractionation. Two preparations of this enzyme have been obtained by gel filtration throug... | [Isolation and several properties of purified preparations of the alkaline ribonuclease of the soluble fraction of rat cerebral hemispheres]. Preparations of alkaline ribonuclease with optimum activity at pH 7,8 have been isolated from postmitochondrial fraction of the rat brain tissue by ammonium sulfate precipitation... | [
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PMID:11845 | [Alpha-glucosidase from human kidneys]. | The data obtained show that most part of the activity of neutral alpha-glucosidases from human kidney is observed in the particle fraction, and only approximately 15%--in supernatant. Soluble neutral alpha-glucosidases have at least 4 different forms, as it is shown by means of their fractionation on Sephadex G-150, Bi... | [Alpha-glucosidase from human kidneys]. The data obtained show that most part of the activity of neutral alpha-glucosidases from human kidney is observed in the particle fraction, and only approximately 15%--in supernatant. Soluble neutral alpha-glucosidases have at least 4 different forms, as it is shown by means of t... | [
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PMID:11848 | Effect of osmotic changes on intracellular pH and haemoglobin oxygen affinity of human erythrocytes. | The effect of osmolality on intra-erythrocytic pH and haemoglobin oxygen affinity of red cells was studied at three different osmolality levels (the mean osmolalities were respectively 257, 294 and 341 mOsmol). No osmotically induced alteration of the pHe-pHi relationship was observed. In contrast, P50(7.4) increased (... | Effect of osmotic changes on intracellular pH and haemoglobin oxygen affinity of human erythrocytes. The effect of osmolality on intra-erythrocytic pH and haemoglobin oxygen affinity of red cells was studied at three different osmolality levels (the mean osmolalities were respectively 257, 294 and 341 mOsmol). No osmot... | [
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PMID:11849 | Lack of effect of methemoglobinemia on the plasma-erythrocyte pH relationship. | A stable and reproducible methemoglobinemia is induced by small concentration of an oxidizing gas (NO). Under such conditions we evidenced that plasma pH (pHe) to erythrocyte pH (pHi) relationship is unchanged. A strong acidity bound to the changes of NO in water occurs. But we may conclude that the buffer capacity of ... | Lack of effect of methemoglobinemia on the plasma-erythrocyte pH relationship. A stable and reproducible methemoglobinemia is induced by small concentration of an oxidizing gas (NO). Under such conditions we evidenced that plasma pH (pHe) to erythrocyte pH (pHi) relationship is unchanged. A strong acidity bound to the ... | [
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PMID:11850 | Evidence of a pure "contraction alkalosis= in awaken rat. | A pure contraction alkalosis with no urinary loss of bicarbonate was evidenced in awaken rat, after a Furosemide IV injection. We observed: 1) an early and important respiratory compensation possibly owing to a simultaneous contraction of CSF volume, thus increasing bicarbonate concentration. 2) a net shift of HCO3- to... | Evidence of a pure "contraction alkalosis= in awaken rat. A pure contraction alkalosis with no urinary loss of bicarbonate was evidenced in awaken rat, after a Furosemide IV injection. We observed: 1) an early and important respiratory compensation possibly owing to a simultaneous contraction of CSF volume, thus increa... | [
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PMID:11851 | The effect of Trichinella spiralis on graft-versus-host reaction, transplantation immunity and antibody formation. | The effect of Trichinella spiralis in different phases of infection on transplantation immunity, the ability of lymphocytes to induce graft-versus-host reaction, on antibody and plaque-forming cell production was studied. In certain phases of Trichinella spiralis beginhing from the first days of infection and during 40... | The effect of Trichinella spiralis on graft-versus-host reaction, transplantation immunity and antibody formation. The effect of Trichinella spiralis in different phases of infection on transplantation immunity, the ability of lymphocytes to induce graft-versus-host reaction, on antibody and plaque-forming cell product... | [
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PMID:11852 | Human serum albumin variants: determination and repartition of allotypes in 24 cases of bisalbuminemia observed in the French population. | Weitkamp et al. (1973) using starch gel electrophoresis in three different systems of buffers (pH 5, 5.6 and 6.9) distinguish at least 24 genetically determined variants. In the European area only seven variants have been observed. The study of 24 cases of bisalbuminemia observed in the french population by acetate ele... | Human serum albumin variants: determination and repartition of allotypes in 24 cases of bisalbuminemia observed in the French population. Weitkamp et al. (1973) using starch gel electrophoresis in three different systems of buffers (pH 5, 5.6 and 6.9) distinguish at least 24 genetically determined variants. In the Euro... | [
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PMID:11853 | Erythrocyte pH in respiratory and metabolic acid-base disturbances. Studies on human blood in vitro. | The influence of oxygenation in respiratory and metabolic acid-base disturbances on erythocyte pH has been studied on normal human blood "in vitro". In physiological pH range, pHe-pHi relationship is the same for PCO2 variations at constant metabolic level and for metablic level variations at constant PCO2. A "global" ... | Erythrocyte pH in respiratory and metabolic acid-base disturbances. Studies on human blood in vitro. The influence of oxygenation in respiratory and metabolic acid-base disturbances on erythocyte pH has been studied on normal human blood "in vitro". In physiological pH range, pHe-pHi relationship is the same for PCO2 v... | [
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PMID:11854 | Production of cellulase by Trichoderma. | The cellulase complex in T. viride is inducible. For large-scale enzyme production the fungus should be cultured on media containing cellulose. The cellulase enzymes are respressible. To produce and maintain best cellulase yields cultural conditions which lead to carbohydrate consumption in excess of cellular needs sho... | Production of cellulase by Trichoderma. The cellulase complex in T. viride is inducible. For large-scale enzyme production the fungus should be cultured on media containing cellulose. The cellulase enzymes are respressible. To produce and maintain best cellulase yields cultural conditions which lead to carbohydrate con... | [
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PMID:11859 | Aplastic anemia treated by allogeneic bone marrow transplantation: a report on 49 new cases from Seattle. | Forty-nine patients with severe aplastic anemia, 33 due to unknown cause, 11 drug or chemical related, 2 associated with hepatitis, 1 with paroxysmal nocturnal hemoglobinuria, and 2 possibly associated with Fanconi syndrome did not show recovery after 0.5-96 (median 2) mo of conventional therapy. Twenty-two were infect... | Aplastic anemia treated by allogeneic bone marrow transplantation: a report on 49 new cases from Seattle. Forty-nine patients with severe aplastic anemia, 33 due to unknown cause, 11 drug or chemical related, 2 associated with hepatitis, 1 with paroxysmal nocturnal hemoglobinuria, and 2 possibly associated with Fanconi... | [
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PMID:11860 | Total folate binding capacity of normal human plasma, and variations in uremia, cirrhosis, and pregnancy. | The current study presents evidence that all human serum contains a class of high-affinity folate binders (KA=2.8 X10(10 liters/mole), which migrate as a single peak on gel filtration. Failure of previous studies to detect this characteristic in all but a minority of subjects is attributable to its variable, often tota... | Total folate binding capacity of normal human plasma, and variations in uremia, cirrhosis, and pregnancy. The current study presents evidence that all human serum contains a class of high-affinity folate binders (KA=2.8 X10(10 liters/mole), which migrate as a single peak on gel filtration. Failure of previous studies t... | [
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PMID:11861 | Cardiovascular effects of dopamine after central administration into conscious cats. | Dopamine (30 and 45 mug) administered intracerebroventricular (i.c.v.) to a group of 10 conscious normotensive cats caused dose-related increases in blood pressure and heart rate. In 4 of these animals the initial cardiovascular stimulant effects of i.c.v. dopamine were followed by hypotension and bradycardia. 2 alpha-... | Cardiovascular effects of dopamine after central administration into conscious cats. Dopamine (30 and 45 mug) administered intracerebroventricular (i.c.v.) to a group of 10 conscious normotensive cats caused dose-related increases in blood pressure and heart rate. In 4 of these animals the initial cardiovascular stimul... | [
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PMID:11862 | On the functional coupling of neurotransmitter uptake and release in brain. | 1 Isolated synaptosomal fractions from mouse forebrains were incubated [14C]-gamma-aminobutyric acid ([14C]-GABA). Release of the accumulated label in high potassium solution was measured. 2 The fractional release dependent upon calcium was decreased by raising the concentration of [14C]-GABA during labeling but was no... | On the functional coupling of neurotransmitter uptake and release in brain. 1 Isolated synaptosomal fractions from mouse forebrains were incubated [14C]-gamma-aminobutyric acid ([14C]-GABA). Release of the accumulated label in high potassium solution was measured. 2 The fractional release dependent upon calcium was dec... | [
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PMID:11863 | Antagonism by some antihistamines of the amino acid-evoked responses recorded from the lobster muscle fibre and the frog spinal cord. | 1 The effects of some antihistamines on the lobster muscle fibre and the frog spinal cord were investigated using intracellular and extracellular recordings, respectively. 2. On lobster muscle, histamine H1-blockers reversibly antagonized responses to bath-applied glutamate, aspartate and quisqualate but not responses ... | Antagonism by some antihistamines of the amino acid-evoked responses recorded from the lobster muscle fibre and the frog spinal cord. 1 The effects of some antihistamines on the lobster muscle fibre and the frog spinal cord were investigated using intracellular and extracellular recordings, respectively. 2. On lobster ... | [
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PMID:11864 | Excretion and metabolism of nikethamide in the horse. | It is well known that nikethamide (N,N-diethylnicotinamide, CoramineR) is metabolized very rapidly to nicotinamide. Hence, there is difficulty in proving that nikethamide has been used as a doping substance because nicotinamide is a normal physiological metabolite in the organism as well as a vitamin preparation. Howev... | Excretion and metabolism of nikethamide in the horse. It is well known that nikethamide (N,N-diethylnicotinamide, CoramineR) is metabolized very rapidly to nicotinamide. Hence, there is difficulty in proving that nikethamide has been used as a doping substance because nicotinamide is a normal physiological metabolite i... | [
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PMID:11865 | The detection of doping agents in blood. | Gas chromatographic screening procedures have been evaluated which permit the detection of stimulants and sedatives in blood after administration of pharmacological doses. The techniques actually used in sample preparations and gas chromatographic work are presented as well as examples of pharmacokinetic studies and po... | The detection of doping agents in blood. Gas chromatographic screening procedures have been evaluated which permit the detection of stimulants and sedatives in blood after administration of pharmacological doses. The techniques actually used in sample preparations and gas chromatographic work are presented as well as e... | [
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PMID:11867 | Gonadal function in young adults after surgical treatment of cryptorchidism. | In a follow-up study of 48 young men who had been surgically treated for cryptorchidism before puberty testicular function was assessed by examining the genitalia, testicular volume, secondary sex characteristics, semen, plasma luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations after luteini... | Gonadal function in young adults after surgical treatment of cryptorchidism. In a follow-up study of 48 young men who had been surgically treated for cryptorchidism before puberty testicular function was assessed by examining the genitalia, testicular volume, secondary sex characteristics, semen, plasma luteinising hor... | [
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PMID:11871 | Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. | Fifty-six brains from middle-aged and elderly normal as well as demented subjects and patients with provisional clinical diagnosis of other neurological and psychiatric diseases were assessed histologically. On this basis the specimens were classified into 14 diagnostic groups. A survey of potential indices of specific... | Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Fifty-six brains from middle-aged and elderly normal as well as demented subjects and patients with provisional clinical diagnosis of other neurological and psychiatric diseases were assessed histologically. On this basis... | [
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PMID:11872 | Development of neurotransmitter uptake in regions of the chick brain. | The uptake of postulated neurotransmitters of their precursors into regions of the developing chick brain and retina has been examined. The transport of low concentrations (around 10(-8) M) of GABA, glutamic acid, choline, dopamine and serotonin into homogenates was sodium and energy dependent and inhibited by a variet... | Development of neurotransmitter uptake in regions of the chick brain. The uptake of postulated neurotransmitters of their precursors into regions of the developing chick brain and retina has been examined. The transport of low concentrations (around 10(-8) M) of GABA, glutamic acid, choline, dopamine and serotonin into... | [
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PMID:11873 | Putative neurotransmitters of the avian visual pathway. | The ability of homogenates of the chick optic lobe to accumulate a series of possible neurotransmitters has been studied. High affinity uptake of several possible neurotransmitters was examined in optic lobes of 21-day-old embryos that had a single eye removed on the third day of incubation and in 23-day-old chicks tha... | Putative neurotransmitters of the avian visual pathway. The ability of homogenates of the chick optic lobe to accumulate a series of possible neurotransmitters has been studied. High affinity uptake of several possible neurotransmitters was examined in optic lobes of 21-day-old embryos that had a single eye removed on ... | [
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PMID:11875 | [Effect of sodium dichloroacetate on hyperlactatemia and hyperpyruvicemia induced by phenformin in the dog]. | In the normal anesthetized dog a continuous perfusion of sodium dichloroacetate (30 mg/kg.h) prevents the increase in blood lactates and pyruvates as well as the lowering of the arterial pH induced by the intraduodenal administration of phenformin (30 mg/kg). Furthermore a perfusion of sodium dichloroacetate (7.5 mg/kg... | [Effect of sodium dichloroacetate on hyperlactatemia and hyperpyruvicemia induced by phenformin in the dog]. In the normal anesthetized dog a continuous perfusion of sodium dichloroacetate (30 mg/kg.h) prevents the increase in blood lactates and pyruvates as well as the lowering of the arterial pH induced by the intrad... | [
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PMID:11876 | Alkaline phosphatase activity, characterization, and subcellular distribution during initial skeletogenesis in the prenatal rat limb. | The specific activity, tissue specificity, and subcellular distribution of alkaline phosphatase were studied in the fetal rat limb during initial cartilage calcification and bone formation. The pH optimum, Km, activation, and inhibition characteristics of the enzyme assayed for in 900 X g supernates of whole limb homog... | Alkaline phosphatase activity, characterization, and subcellular distribution during initial skeletogenesis in the prenatal rat limb. The specific activity, tissue specificity, and subcellular distribution of alkaline phosphatase were studied in the fetal rat limb during initial cartilage calcification and bone formati... | [
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0.008643150329589844,
0... |
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