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PMID:11877 | The seeded growth of calcium phosphates. The kinetics of growth of dicalcium phosphate dihydrate on hydroxyapatite. | The kinetics of growth of calcium phosphate on synthetic HAP seed crystals has been studied at 37 degrees C and at pH values of 4.5 and 5.0 by the pH-stat controlled addition of base. Following an induction, DCPD crystal growth takes place with growth kinetics characteristic of the crystallization of pure DCPD seed. Th... | The seeded growth of calcium phosphates. The kinetics of growth of dicalcium phosphate dihydrate on hydroxyapatite. The kinetics of growth of calcium phosphate on synthetic HAP seed crystals has been studied at 37 degrees C and at pH values of 4.5 and 5.0 by the pH-stat controlled addition of base. Following an inducti... | [
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PMID:11878 | Pyrophosphatase and ATPase of isolated cartilage matrix vesicles. | Some of the characteristics of the pyrophosphatase and ATPase activities studied in isolated cartilage matrix vesicles were found to be similar to those already reported for the solubilized and purified bone alkaline phosphatase. Thus, the pH optimum of the pyrophosphatase activity responded similarly to changes in the... | Pyrophosphatase and ATPase of isolated cartilage matrix vesicles. Some of the characteristics of the pyrophosphatase and ATPase activities studied in isolated cartilage matrix vesicles were found to be similar to those already reported for the solubilized and purified bone alkaline phosphatase. Thus, the pH optimum of ... | [
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PMID:11879 | The hydrolytic activity of L-ascorbic acid. | The ability of L-ascorbic acid to catalyze the liberation of 4-methylumbelliferone from 4-methylumbelliferyl-beta-D-N-acetylglucosaminide, 4-methylumbelliferyl-beta-D-glucuronide, 4-methylumbelliferyl-alpha-D-mannoside, and 4-methylumbelliferyl-beta-D-galactoside is documented. There is an apparent metal and oxygen dep... | The hydrolytic activity of L-ascorbic acid. The ability of L-ascorbic acid to catalyze the liberation of 4-methylumbelliferone from 4-methylumbelliferyl-beta-D-N-acetylglucosaminide, 4-methylumbelliferyl-beta-D-glucuronide, 4-methylumbelliferyl-alpha-D-mannoside, and 4-methylumbelliferyl-beta-D-galactoside is documente... | [
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PMID:11880 | Adenosine triphosphate - dependent calcium binding and accumulation by guinea pig cardiac sarcolemma. | Sarcolemma isolated from guinea pig heart ventricles possessed ATP-dependent Ca2+ binding and accumulation (+ oxalate) activities which were not inhibited by sodium azide, oligomycin, or ruthenium red. Ca2+ binding and accumulation by sarcolemma were sensitive to pH, the optimum being about pH 6.8. The concentrations o... | Adenosine triphosphate - dependent calcium binding and accumulation by guinea pig cardiac sarcolemma. Sarcolemma isolated from guinea pig heart ventricles possessed ATP-dependent Ca2+ binding and accumulation (+ oxalate) activities which were not inhibited by sodium azide, oligomycin, or ruthenium red. Ca2+ binding and... | [
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PMID:11881 | Histone-histone interactions. II. Structural stability of the histone H3-H4 complex. | The stability of the histone H3-H4 complex toward urea, changes in pH and ionic strength, and certain chemical modifications have been examined by gel electrophoresis anc circular dichronism. When uncomplexed, the two cysteine residues of histone H3 become rapidly oxidized, forming an intramolecular disulfide bridge wh... | Histone-histone interactions. II. Structural stability of the histone H3-H4 complex. The stability of the histone H3-H4 complex toward urea, changes in pH and ionic strength, and certain chemical modifications have been examined by gel electrophoresis anc circular dichronism. When uncomplexed, the two cysteine residues... | [
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PMID:11882 | Circular dichroism studies of sheep beta-lipotropic hormone. | The far ultraviolet circular dichroism spectra of sheep beta-lipotropic hormone (beta-LPH) were recorded under different conditions of pH, temperature, salt concentration, and solvent composition. Results confirm the stability of the hormone in strong basic or acidic solutions; moreover, temperatures up to 50 degrees C... | Circular dichroism studies of sheep beta-lipotropic hormone. The far ultraviolet circular dichroism spectra of sheep beta-lipotropic hormone (beta-LPH) were recorded under different conditions of pH, temperature, salt concentration, and solvent composition. Results confirm the stability of the hormone in strong basic o... | [
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PMID:11883 | The fusion of erythrocytes by treatment with proteolytic enzymes and polyethylene glycol. | Polyethylene glycol (PEG) has been utilized to induce homokaryocyte formation in avian and mammalian erythrocytes previously treated with proteolytic enzymes. PEG of molecular weight 6,000-7,5000 was found superior to 1,500 and 20,000 MW PEG. Cells exposed to protease alone, prior to PEG treatment, fused to a high degr... | The fusion of erythrocytes by treatment with proteolytic enzymes and polyethylene glycol. Polyethylene glycol (PEG) has been utilized to induce homokaryocyte formation in avian and mammalian erythrocytes previously treated with proteolytic enzymes. PEG of molecular weight 6,000-7,5000 was found superior to 1,500 and 20... | [
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PMID:11884 | Congenital retroflexion of the penis and inguinal cryptorchidism in a presumptive bovine twin with a 60,XY/60,XX/61,XX,+cen chromosome constitution. | Studies were carried out on a yearling Holstein with external genitalia resembling those of a freemartin whose birth and developmental history was unknown. Dissection following slaughter showed testes close to the external inguinal rings, an underdeveloped penis coiled up subcutaneously in the perineum and terminating ... | Congenital retroflexion of the penis and inguinal cryptorchidism in a presumptive bovine twin with a 60,XY/60,XX/61,XX,+cen chromosome constitution. Studies were carried out on a yearling Holstein with external genitalia resembling those of a freemartin whose birth and developmental history was unknown. Dissection foll... | [
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PMID:11886 | Isoferritin composition of tissues and serum in human cancers. | A highly sensitive technique for isoferritin detection using 125I-labeled monospecific anti-human liver ferritin antibody for the identification of isoferritins after the analysis of small quantities of ferritin by isoelectric focusing in polyacryl-amide gels was applied to the study of renal, pancreatic, and colonic c... | Isoferritin composition of tissues and serum in human cancers. A highly sensitive technique for isoferritin detection using 125I-labeled monospecific anti-human liver ferritin antibody for the identification of isoferritins after the analysis of small quantities of ferritin by isoelectric focusing in polyacryl-amide ge... | [
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PMID:11887 | Increased guanylate cyclase activity and guanosine 3',5'-monophosphate content in ethionine-induced hepatomas. | Ethionine-induced hepatomas are characterized by high adenylate cyclase activity and cyclic adenosine 3',5'-monophosphate content relative to those of surrounding liver or liver from pair-fed control rats. The present study examined the properties of the guanylate cyclase-cyclic guanosine 3',5'-monophosphate (cGMP) sys... | Increased guanylate cyclase activity and guanosine 3',5'-monophosphate content in ethionine-induced hepatomas. Ethionine-induced hepatomas are characterized by high adenylate cyclase activity and cyclic adenosine 3',5'-monophosphate content relative to those of surrounding liver or liver from pair-fed control rats. The... | [
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PMID:11888 | Activation of guanylate cyclase by streptozotocin and 1-methyl-1-nitrosourea. | Streptozotocin has been shown to induce the production of a variety of tumors in rats. The present report demonstrates that streptozotocin and 1-methyl-1-nitrosourea, a component of the streptozotocin molecule and a known carcinogen, stimulate the enzyme guanylate cyclase which catalyzes the production of guanosine 3',... | Activation of guanylate cyclase by streptozotocin and 1-methyl-1-nitrosourea. Streptozotocin has been shown to induce the production of a variety of tumors in rats. The present report demonstrates that streptozotocin and 1-methyl-1-nitrosourea, a component of the streptozotocin molecule and a known carcinogen, stimulat... | [
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PMID:11889 | Use of an elemental diet in animals during treatment with 5-fluorouracil (NSC-19893). | Rats eating a diet containing casein hydrolysate (10% wt/wt)(diet 3) instead of whole casein (diet 1) exhibited increased tolerance to nine consecutive daily injections of 15 mg/kg of 5-fluorouracil (5-FU). The relative nutritional efficiency of diet 3 was significantly higher during 5-FU treatment. Serum albumin level... | Use of an elemental diet in animals during treatment with 5-fluorouracil (NSC-19893). Rats eating a diet containing casein hydrolysate (10% wt/wt)(diet 3) instead of whole casein (diet 1) exhibited increased tolerance to nine consecutive daily injections of 15 mg/kg of 5-fluorouracil (5-FU). The relative nutritional ef... | [
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PMID:11893 | [Daily variations of the level of neural secretions in Owenia fusiformis. Persistance of a daily rhythm in cultured tissues]. | A quantitative study of elementary granules in neuron axons of the nervous chain of Owenia fusiformis (Annelid polychaete) shows that daily variations of the number of secretory granules occur in unamputated animals and in ventral tissue cultures. These variations are correlated with the thythm of the cell cycle. | [Daily variations of the level of neural secretions in Owenia fusiformis. Persistance of a daily rhythm in cultured tissues]. A quantitative study of elementary granules in neuron axons of the nervous chain of Owenia fusiformis (Annelid polychaete) shows that daily variations of the number of secretory granules occur i... | [
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PMID:11894 | [Demonstration of different metabolic pathways starting with glucose or fructose in Rhizobium meliloti]. | Rhizobium meliloti can produce many polysaccharides on D-fructose and D-mannitol. In glucose-grown cultures, few polysaccharides are observed and 2 keto-gluconate is accumulated. | [Demonstration of different metabolic pathways starting with glucose or fructose in Rhizobium meliloti]. Rhizobium meliloti can produce many polysaccharides on D-fructose and D-mannitol. In glucose-grown cultures, few polysaccharides are observed and 2 keto-gluconate is accumulated. | [
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PMID:11895 | [Enzymatic characteristics of the guanylate cyclase of KB cells: their change as a function of the development of the cultures]. | We have localized 71% of the guanylate cyclase activity in the (G X 105,000) supernatent fraction of broken KB cells. The reaction follows Michaelis-Menten kinetics, the apparent Km for GTP is 0,5 mM, as long as GTP is lower than a limited concentration, then activity is inhibited. The ion Mn++ is an absolutely require... | [Enzymatic characteristics of the guanylate cyclase of KB cells: their change as a function of the development of the cultures]. We have localized 71% of the guanylate cyclase activity in the (G X 105,000) supernatent fraction of broken KB cells. The reaction follows Michaelis-Menten kinetics, the apparent Km for GTP i... | [
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PMID:11896 | Facial vein in the rabbit. Neurogenic vasodilation mediated by beta-adrenergic receptors. | A segment of the facial vein of the rabbit, that opposite the buccal cavity, responds to norepinephrine (NE) and opposite the buccal cavity, responds to norepinephrine (NE) and transmural nerve stimulation (TNS) by a brisk biphasic dilation. The dilation in response to both procedures is reveresed by prior exposure to ... | Facial vein in the rabbit. Neurogenic vasodilation mediated by beta-adrenergic receptors. A segment of the facial vein of the rabbit, that opposite the buccal cavity, responds to norepinephrine (NE) and opposite the buccal cavity, responds to norepinephrine (NE) and transmural nerve stimulation (TNS) by a brisk biphasi... | [
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PMID:11897 | Diazotization of catecholamines and their analogs and metabolites for urinary screening tests: chemical aspects. | Coupling of diazotized p-nitroaniline to catecholamines and their metabolites in urine has been proposed for use in screening for secreting neuroblastoma in childhood. We have coupled diazotized p-nitroaniline to catecholamines, derivatives, and metabolites and examined the reaction products by thin-layer chromatograph... | Diazotization of catecholamines and their analogs and metabolites for urinary screening tests: chemical aspects. Coupling of diazotized p-nitroaniline to catecholamines and their metabolites in urine has been proposed for use in screening for secreting neuroblastoma in childhood. We have coupled diazotized p-nitroanili... | [
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PMID:11898 | A mechanism for the conversion of oxyhemoglobin to methemoglobin by nitrite. | Each mole of oxyhemoglobin iron converted to methemoglobin causes the oxidation of 1.5 mol of nitrite to nitrate and consumes 1 mol of protons. No oxygen is liberated. The overall reaction has two simultaneously occurring parts. In the beginning the rate-limiting reaction converting O2Hb to metHb is directly proportion... | A mechanism for the conversion of oxyhemoglobin to methemoglobin by nitrite. Each mole of oxyhemoglobin iron converted to methemoglobin causes the oxidation of 1.5 mol of nitrite to nitrate and consumes 1 mol of protons. No oxygen is liberated. The overall reaction has two simultaneously occurring parts. In the beginni... | [
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PMID:11899 | Relation of pH to fluorescence of serotonin, melatonin, and other indole compounds reacted with o-phthaldialdehyde. | We distinguished serotonin, malatonin, and other indole compounds by their markedly different fluorescence behavior when heated with o-phthaldialdehyde in different concentration of HCl, or after the subsequent addition of alkali. Fluorescence may increase, disappear, or change from blue to orange-red. Only melatonin d... | Relation of pH to fluorescence of serotonin, melatonin, and other indole compounds reacted with o-phthaldialdehyde. We distinguished serotonin, malatonin, and other indole compounds by their markedly different fluorescence behavior when heated with o-phthaldialdehyde in different concentration of HCl, or after the subs... | [
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PMID:11900 | An optimized continuous-monitoring procedure for semiautomated determination of serum acid phosphatase activity. | A continuous-monitoring method for measuring acid phosphatase activity with alpha-naphthyl phosphate as the substrate was critically evaluated and modified. Using partially purified prostatic acid phosphatase, we show that certain conditions for the assay must be satisfied to ensure linearity. These conditions include ... | An optimized continuous-monitoring procedure for semiautomated determination of serum acid phosphatase activity. A continuous-monitoring method for measuring acid phosphatase activity with alpha-naphthyl phosphate as the substrate was critically evaluated and modified. Using partially purified prostatic acid phosphatas... | [
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PMID:11901 | Enzymatic rate method for measuring cholesterol in serum. | An enzymatic rate assay is described for measuring cholesterol in serum. Cholesterol is analyzed by mixing 5 mul of sample with a reagent consisting of cholesterol esterase, cholesterol oxidase, catalase, acetylacetone, methanol, and hydroxypolyethoxydodecane in a ammonium phosphate buffer at pH 7.0. The rate of incre... | Enzymatic rate method for measuring cholesterol in serum. An enzymatic rate assay is described for measuring cholesterol in serum. Cholesterol is analyzed by mixing 5 mul of sample with a reagent consisting of cholesterol esterase, cholesterol oxidase, catalase, acetylacetone, methanol, and hydroxypolyethoxydodecane in... | [
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PMID:11905 | Erythrocyte glutathione synthetase in 5-oxoprolinuria: kinetic studies of the mutant enzyme and detection of heterozygotes. | The primary metabolic defect in 5-oxoprolinuria is a generalized deficiency of glutathione synthetase. The activity of this enzyme was determined in cell-free extracts of erythrocytes from patients with 5-oxoprolinuria, their parents and a sibling as well as from normal control individuals. The following activities (pk... | Erythrocyte glutathione synthetase in 5-oxoprolinuria: kinetic studies of the mutant enzyme and detection of heterozygotes. The primary metabolic defect in 5-oxoprolinuria is a generalized deficiency of glutathione synthetase. The activity of this enzyme was determined in cell-free extracts of erythrocytes from patient... | [
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PMID:11906 | A microfluorometric assay of leukocyte alpha-1,4-glucosidase. | We describe an improved method for detecting deficiency of the acid hydrolase, alpha-1,4-glucosidase in leukocytes, the enzyme defect in glycogen storage disease Type II (Pompe disease). The procedure requires smaller volumes of blood and less time than previous methods. The assay involves the separation of leukocytes ... | A microfluorometric assay of leukocyte alpha-1,4-glucosidase. We describe an improved method for detecting deficiency of the acid hydrolase, alpha-1,4-glucosidase in leukocytes, the enzyme defect in glycogen storage disease Type II (Pompe disease). The procedure requires smaller volumes of blood and less time than prev... | [
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PMID:11907 | Studies on gamma-glutamyl transpeptidase of human urine. | A simple and rapid method suitable for clinical laboratories, for the removal of the inhibitors in urine of gamma-glutamyl transpeptidase activity, using an ion-retardation resin, is described. Gel chromatography of urine resulted in appreciable loss of the enzyme activity. Freezing at -5 degrees C and thawing, did not... | Studies on gamma-glutamyl transpeptidase of human urine. A simple and rapid method suitable for clinical laboratories, for the removal of the inhibitors in urine of gamma-glutamyl transpeptidase activity, using an ion-retardation resin, is described. Gel chromatography of urine resulted in appreciable loss of the enzym... | [
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PMID:11908 | Studies on the multiple forms of gamma-glutamyltransferase. | In sera of 53 patients with highly raised gamma-glutamyltransferase (gamma-GT) (EC 2.3.2.2) activity, the gamma-GT was separated by column chromatography on Sephadex DEAE A-50 into two fractions. In 35 sera only one gamma-GT fraction was found at a conductivity of 2.0--2.5 mS and in 18 sera two gamma-GT fractions were ... | Studies on the multiple forms of gamma-glutamyltransferase. In sera of 53 patients with highly raised gamma-glutamyltransferase (gamma-GT) (EC 2.3.2.2) activity, the gamma-GT was separated by column chromatography on Sephadex DEAE A-50 into two fractions. In 35 sera only one gamma-GT fraction was found at a conductivit... | [
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PMID:11910 | Human leucocyte alpha-L-fucosidase. | 1. Human alpha-L-fucosidase (EC 3.2.1.51) was studied from leucocytes, urine and serum. 2. The leucocyte and urine enzymes are similar in many properties (KM, pH optimum, electrophoretic pattern, heat stability). 3. The serum alpha-L-fucosidase differs from the leucocyte and 4rine enzyme wit,respect to: electrophoretic... | Human leucocyte alpha-L-fucosidase. 1. Human alpha-L-fucosidase (EC 3.2.1.51) was studied from leucocytes, urine and serum. 2. The leucocyte and urine enzymes are similar in many properties (KM, pH optimum, electrophoretic pattern, heat stability). 3. The serum alpha-L-fucosidase differs from the leucocyte and 4rine en... | [
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PMID:11911 | Characterization of alpha-L-fucosidase from two different families with fucosidosis. | 1. Two different families with a different type of fucosidase deficiency are described. 2. In the first family the activity of alpha-L-fucosidase in leucocytes of two patients with fucosidosis type I was about 4 to 8% of the normal value. The activity of alpha-L-fucosidase in the leucocytes of the father and the mother... | Characterization of alpha-L-fucosidase from two different families with fucosidosis. 1. Two different families with a different type of fucosidase deficiency are described. 2. In the first family the activity of alpha-L-fucosidase in leucocytes of two patients with fucosidosis type I was about 4 to 8% of the normal val... | [
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PMID:11913 | Rapid colorimetric assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine. | Colorimetric methods using 4-nitrophenyl-glycoside substrates for the assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine are described. Interfering substances were removed by gel-filtration of urine. An unidentified low-molecular-weight inhibitor of N-acetyl-beta-glucosaminidase was found. Inc... | Rapid colorimetric assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine. Colorimetric methods using 4-nitrophenyl-glycoside substrates for the assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine are described. Interfering substances were removed by gel-filtration of urin... | [
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PMID:11914 | Comparative studies on cholesterol oxidases from different sources. | 1. Comparison of the characteristics of cholesterol oxidases from different sources was made by a new polarographic method for measurement of the oxygen-consumption rate. 2. A pH optimum of 7.0 was observed for cholesterol oxidases isolated from Nocardia and Brevibacterium, pH 5.0 for the enzyme from Schizophyllum and ... | Comparative studies on cholesterol oxidases from different sources. 1. Comparison of the characteristics of cholesterol oxidases from different sources was made by a new polarographic method for measurement of the oxygen-consumption rate. 2. A pH optimum of 7.0 was observed for cholesterol oxidases isolated from Nocard... | [
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PMID:11915 | Catecholamine-sensitive adenylate cyclase of human fat cell ghosts. Characteristics of the GMP(PNP)-liganded state. | The effects of 5'-guanylyl-imidodiphosphate (GMP(PNP)) on the catecholamine-sensitive adenylate cyclase of human fat cell ghosts were studied. The compound increased basal and epinephrine-stimulated enzyme activity by about 300%; in addition GMP(PNP) increased hormone sensitivity by reducing the epinephrine concentrati... | Catecholamine-sensitive adenylate cyclase of human fat cell ghosts. Characteristics of the GMP(PNP)-liganded state. The effects of 5'-guanylyl-imidodiphosphate (GMP(PNP)) on the catecholamine-sensitive adenylate cyclase of human fat cell ghosts were studied. The compound increased basal and epinephrine-stimulated enzym... | [
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PMID:11916 | Galactose-1-phosphate uridyltransferase in cultured cells. | A method to measure the enzyme galactose-1-phosphate uridyltransferase in cultured cells is described. The optimun pH was 8.7 and no enzyme activity was found without preincubation with dithiothreitol. The KM values for Gal-1-P and UDPG for the wild type enzyme were found to be 0.2 mM and 0.08 mM, respectively. Values ... | Galactose-1-phosphate uridyltransferase in cultured cells. A method to measure the enzyme galactose-1-phosphate uridyltransferase in cultured cells is described. The optimun pH was 8.7 and no enzyme activity was found without preincubation with dithiothreitol. The KM values for Gal-1-P and UDPG for the wild type enzyme... | [
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PMID:11959 | Herbicides and soil microorganisms. | The production and usage of herbicides have increased dramatically in recent years. Consequently there is growing concern about the effects of these chemicals on the environment, particularly the possible long-term effects on soil fertility which may result from disturbance of the soil microflora. This review considers... | Herbicides and soil microorganisms. The production and usage of herbicides have increased dramatically in recent years. Consequently there is growing concern about the effects of these chemicals on the environment, particularly the possible long-term effects on soil fertility which may result from disturbance of the so... | [
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PMID:11960 | Evaluation of anxiolytic and amnesic effects of intramuscular lorazepam as a pre-operative medication. | In a double-blind investigation in 21 patients undergoing minor plastic surgery the effects of 4 mg lorazepam or a mixture of 20 mg papaveretum/400 mug hyoscine given intramuscularly as premedicants were studied. Lorazepam produced superior preoperative and post-operative anterograde amnesia, with respect to both incid... | Evaluation of anxiolytic and amnesic effects of intramuscular lorazepam as a pre-operative medication. In a double-blind investigation in 21 patients undergoing minor plastic surgery the effects of 4 mg lorazepam or a mixture of 20 mg papaveretum/400 mug hyoscine given intramuscularly as premedicants were studied. Lora... | [
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PMID:11961 | Lorazepam in the treatment of neurosis. | An open study was carried out in 40 ambulatory neurotic patients with classical symptoms of anxiety to assess which of their symptoms responded most readily and favourably to treatment with lorazepam. Doses ranged from 2 mg to 15 mg daily and were adjusted to individual patient needs. The study period lasted 4 weeks an... | Lorazepam in the treatment of neurosis. An open study was carried out in 40 ambulatory neurotic patients with classical symptoms of anxiety to assess which of their symptoms responded most readily and favourably to treatment with lorazepam. Doses ranged from 2 mg to 15 mg daily and were adjusted to individual patient n... | [
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PMID:11963 | The role of HCO3-stimulated ATPase in buffer transport. | An ATPase stimulated by HCO-3ions and other oxybases and inhibited by SCN- has been found in main excretory duct of rat submaxillary gland, a tissue, capable of actively secreting HCO-3ions. No such ATPase was found in the rabbit duct, which normally does not secrete HCO-3. The HCO-3ATPase was localized in the plasma m... | The role of HCO3-stimulated ATPase in buffer transport. An ATPase stimulated by HCO-3ions and other oxybases and inhibited by SCN- has been found in main excretory duct of rat submaxillary gland, a tissue, capable of actively secreting HCO-3ions. No such ATPase was found in the rabbit duct, which normally does not secr... | [
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PMID:11964 | Polarity of proximal tubular epithelial cells in relation to transepithelial transport. | Transport properties of brush border microvilli and basal-lateral plasma membranes isolated from rat kidney cortex were studied by a millipore filtration technique. Brush border microvilli but not basal-lateral plasma membranes contain sodium dependent stereospecific transport system for D-glucose, L-phenylalanine and ... | Polarity of proximal tubular epithelial cells in relation to transepithelial transport. Transport properties of brush border microvilli and basal-lateral plasma membranes isolated from rat kidney cortex were studied by a millipore filtration technique. Brush border microvilli but not basal-lateral plasma membranes cont... | [
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PMID:11965 | Properties of rat kidney glutaminase enzymes and their role in renal ammoniagenesis. | Rat kidney contains two distinct glutaminase activities; the mitochondrial phosphate-dependent glutaminase and a second glutaminase activity associated with the brush border membrane which is maleate-activated and phosphate-independent. It has recently been shown that the phosphate-independent glutaminase is a partial ... | Properties of rat kidney glutaminase enzymes and their role in renal ammoniagenesis. Rat kidney contains two distinct glutaminase activities; the mitochondrial phosphate-dependent glutaminase and a second glutaminase activity associated with the brush border membrane which is maleate-activated and phosphate-independent... | [
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PMID:11966 | On the role of gamma-glutamyltransferase in renal tubular amino acid reabsorption. | The degradation of glutathione in the kidney of the rat was investigated in vivo and in vitro. When radioactive glutathione or its analogue ophthalmic acid was administered intravenously to mice or rats, the tripeptides were rapidly and completely degraded. Within the organs, no radioactive glutathione, but only labell... | On the role of gamma-glutamyltransferase in renal tubular amino acid reabsorption. The degradation of glutathione in the kidney of the rat was investigated in vivo and in vitro. When radioactive glutathione or its analogue ophthalmic acid was administered intravenously to mice or rats, the tripeptides were rapidly and ... | [
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PMID:11967 | The influence of branched chain aminoacids and their ketoderivatives on renal gluconeogenesis. | Isolated kidney tubules served as a model to investigate the direct effect of branched chain aminoacids and their ketoderivatives on gluconeogenesis. The data presented in this paper demonstrate that the ketoderivatives rather than the branched chain aminoacids themselves inhibit renal glucosesynthesis from various pre... | The influence of branched chain aminoacids and their ketoderivatives on renal gluconeogenesis. Isolated kidney tubules served as a model to investigate the direct effect of branched chain aminoacids and their ketoderivatives on gluconeogenesis. The data presented in this paper demonstrate that the ketoderivatives rathe... | [
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PMID:11969 | Human mitochondrial NADP-dependent isocitrate dehydrogenase in man-mouse somatic cell hybrids. | Human mitochondrial NADP-dependent isocitrate dehydrogenase (IDH-2) is expressed in man-mouse somatic cell hybrids as a dimeric molecule. The gene specifing this enzyme was observed to be syntenic with the mannose phosphate isomerase locus in the 56 primary man-mouse clones in this series. The human IDH-2 locus, theref... | Human mitochondrial NADP-dependent isocitrate dehydrogenase in man-mouse somatic cell hybrids. Human mitochondrial NADP-dependent isocitrate dehydrogenase (IDH-2) is expressed in man-mouse somatic cell hybrids as a dimeric molecule. The gene specifing this enzyme was observed to be syntenic with the mannose phosphate i... | [
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PMID:11970 | Immediate hypersensitivity to tuberculin. In vivo and in vitro studies. | Immediate responses of hypersensitivity to skin testing with purified derivative of tuberculin (PPD) were observed in 2.3 percent of 3,248 patients seen in an allergy clinic, and the relationship to delayed responses was questioned. Immediate cutaneous reactions to testing with PPD appeared in all age groups and occurr... | Immediate hypersensitivity to tuberculin. In vivo and in vitro studies. Immediate responses of hypersensitivity to skin testing with purified derivative of tuberculin (PPD) were observed in 2.3 percent of 3,248 patients seen in an allergy clinic, and the relationship to delayed responses was questioned. Immediate cutan... | [
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PMID:11971 | Organ and species differences in microsomal activation of methyldopa. | The covalent binding of 3H-methyldopa to microsomal protein in the presence of NADHP and oxygen was studied in various microsomal preparations. Rat and mouse liver microsomes showed high binding, hamster and guinea pig liver microsomes gave intermediate values, whereas no binding was seen with rabbit liver microsomes. ... | Organ and species differences in microsomal activation of methyldopa. The covalent binding of 3H-methyldopa to microsomal protein in the presence of NADHP and oxygen was studied in various microsomal preparations. Rat and mouse liver microsomes showed high binding, hamster and guinea pig liver microsomes gave intermedi... | [
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PMID:11972 | Xenobiotic metabolism and enzyme induction in isolated rat intestinal microsomes. | Intestinal microsomes were isolated from rats pretreated with 3-methylcholanthrene (MC), phenobarbital (PB), and pregnenolone-16alpha-carbonitrile (PCN). The metabolism of benzo[a]pyrene (BP), 7-ethoxyresorufin, 7-ethoxycoumarin, and biphenyl were examined. MC induces a 30-fold increase in BP metabolism. With control m... | Xenobiotic metabolism and enzyme induction in isolated rat intestinal microsomes. Intestinal microsomes were isolated from rats pretreated with 3-methylcholanthrene (MC), phenobarbital (PB), and pregnenolone-16alpha-carbonitrile (PCN). The metabolism of benzo[a]pyrene (BP), 7-ethoxyresorufin, 7-ethoxycoumarin, and biph... | [
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PMID:11973 | The rat brain as a "deep compartment" in the kinetics of a common metabolite of prochlorperazine and perphenazine. | N-[gamma-(2-Chlorophenothiazin-10-yl)propyl]ethylenediamine (Cl-PPED), a common metabolite of prochlorperazine and perphenazine, was orally administered to male rats at a dose of 50 mg/kg, and its concentrations in plasma, liver, lung, kidney, and brain were followed from 6 hr to 40 days after dosage. Small quantities... | The rat brain as a "deep compartment" in the kinetics of a common metabolite of prochlorperazine and perphenazine. N-[gamma-(2-Chlorophenothiazin-10-yl)propyl]ethylenediamine (Cl-PPED), a common metabolite of prochlorperazine and perphenazine, was orally administered to male rats at a dose of 50 mg/kg, and its concent... | [
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PMID:11974 | Localization of nicotine-14C, cotinine-14C, and nicotine-1'-N-oxide-14C in tissues of the mouse. | The distrubutions of nicotine-14C (2'- or methyl-labeled), cotinine-14C, and nicotine-1'-N-oxide-14C were studied by whole-body autoradiography in mice and in perfused rabbit lung. The compounds were administered either iv, sc, ip, or by inhalation. Blank sections were also incubated with nicotine-14C and cotinine-14C ... | Localization of nicotine-14C, cotinine-14C, and nicotine-1'-N-oxide-14C in tissues of the mouse. The distrubutions of nicotine-14C (2'- or methyl-labeled), cotinine-14C, and nicotine-1'-N-oxide-14C were studied by whole-body autoradiography in mice and in perfused rabbit lung. The compounds were administered either iv,... | [
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PMID:11975 | Effect of sex hormones on the disposition in rats of 1-aminocyclohexane carboxylic acid, a metabolite of semisynthetic penicillin. | The renal clearance of 1-aminocyclohexanecarboxylic acid (ACHC), a metabolite of the semisynthetic penicillin, cyclacillin, is about 10 times faster in female than in male rats. The slower clearance in males is attributed to a higher net rate of reabsorption of the compound from the tubule of the kidney. Because ACHC i... | Effect of sex hormones on the disposition in rats of 1-aminocyclohexane carboxylic acid, a metabolite of semisynthetic penicillin. The renal clearance of 1-aminocyclohexanecarboxylic acid (ACHC), a metabolite of the semisynthetic penicillin, cyclacillin, is about 10 times faster in female than in male rats. The slower ... | [
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PMID:11976 | Species differences in the metabolism and disposition of spironolactone. | The absorption, excretion and metabolism of [22-14C]spironolactone was compared in Charles River rats, beagle dogs and rhesus monkeys. The drug was administered at the fixed dose of 5 mg/kg po and iv. From the po/iv ratios of the areas under the plasma radioactivity-time curves, the gastrointestinal absorption of the d... | Species differences in the metabolism and disposition of spironolactone. The absorption, excretion and metabolism of [22-14C]spironolactone was compared in Charles River rats, beagle dogs and rhesus monkeys. The drug was administered at the fixed dose of 5 mg/kg po and iv. From the po/iv ratios of the areas under the p... | [
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PMID:11977 | The formation of cytochrome P-450-metabolic intermediate complexes in microsomal fractions from extrahepatic tissues of the rabbit. | Cytochrome P-450-metabolic intermediate complexes were formed from N-hydroxyamphetamine, benzphetamine, norbenzphetamine, and d- and l-amphetamine in lung microsomal fractions and from N-hydroxyamphetamine in small intestinal mucosa microsomal fractions. Complexes were not formed in either tissue from SKF 525-A or prop... | The formation of cytochrome P-450-metabolic intermediate complexes in microsomal fractions from extrahepatic tissues of the rabbit. Cytochrome P-450-metabolic intermediate complexes were formed from N-hydroxyamphetamine, benzphetamine, norbenzphetamine, and d- and l-amphetamine in lung microsomal fractions and from N-h... | [
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PMID:11978 | Identification of basic metabolites of 4-[4-(p-chlo- robenzoyl)piperidino]-4'-fluorobutyrophenone, an experimental neuroleptic agent. | Two metabolites of 4-[4-(p-(chlorobenzoyl)piperidino]-4'-fluorobutyrophenone (RMI 9901) as well as unchanged drug, have been identified in the urine of rats following oral administration of the drug. Analysis of basic urine extracts by combined gas chromatography-mass spectrometry was employed for metabolite identifica... | Identification of basic metabolites of 4-[4-(p-chlo- robenzoyl)piperidino]-4'-fluorobutyrophenone, an experimental neuroleptic agent. Two metabolites of 4-[4-(p-(chlorobenzoyl)piperidino]-4'-fluorobutyrophenone (RMI 9901) as well as unchanged drug, have been identified in the urine of rats following oral administration... | [
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PMID:11982 | [Serum-gastrin levels and gastric-acid secretion in infants (author's transl)]. | Gastric acid secretion was measured in 20 infants aged 6-438 days. The values for the basal acid output and that after stimulation with 6 mug/kg pentagastrin subcutaneously were found to be related to age, body weight and body surface area. But these correlations were not comparable to those in adults. Standard values ... | [Serum-gastrin levels and gastric-acid secretion in infants (author's transl)]. Gastric acid secretion was measured in 20 infants aged 6-438 days. The values for the basal acid output and that after stimulation with 6 mug/kg pentagastrin subcutaneously were found to be related to age, body weight and body surface area.... | [
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PMID:11979 | Metabolism of methoxyphenamine in man and in monkey. | Metabolites of methoxyphenamine in the urine of human subjects and monkeys were separated by gas-liquid chromatography and identified by comparison of their chromatographic and mass spectrometric behavior with those of synthetic compounds. Aromatic O-demethylation, aromatic ring hydroxylation (both followed by glucuron... | Metabolism of methoxyphenamine in man and in monkey. Metabolites of methoxyphenamine in the urine of human subjects and monkeys were separated by gas-liquid chromatography and identified by comparison of their chromatographic and mass spectrometric behavior with those of synthetic compounds. Aromatic O-demethylation, a... | [
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PMID:11980 | A method for the measurement of L-phenylalanine mustard in the mouse and dog by high-pressure liquid chromatography. | The distribution of L-phenylalanine mustard (L-PAM) was studied in dogs and mice by high-pressure liquid chromatography. Separation of L-PAM from its products of hydrolysis was accomplished with a mu-Bondapak C18 column, a solvent system composed of 2-methoxyethanol/0.1% acetic acid, and solvent programming with a step... | A method for the measurement of L-phenylalanine mustard in the mouse and dog by high-pressure liquid chromatography. The distribution of L-phenylalanine mustard (L-PAM) was studied in dogs and mice by high-pressure liquid chromatography. Separation of L-PAM from its products of hydrolysis was accomplished with a mu-Bon... | [
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PMID:11984 | [Lactic acidosis in diabetics on biguanides (author's transl)]. | A systematic search for cases of lactic acidosis among diabetics on biguanides revealed ten during an eight-month period, while in the preceding ten years not a single case had been definitely diagnosed. This represents a prevelance of 1 in 2000 patients admitted to hospital. All ten were over 60 years old and had prev... | [Lactic acidosis in diabetics on biguanides (author's transl)]. A systematic search for cases of lactic acidosis among diabetics on biguanides revealed ten during an eight-month period, while in the preceding ten years not a single case had been definitely diagnosed. This represents a prevelance of 1 in 2000 patients a... | [
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PMID:11986 | [Alcohol-psychotropic drug interactions]. | The problem of ethanol interactions with psychotropic drugs involves various factors whose complex action is examined in this article. Great care should be taken with regard to the alcohol consumption among patients treated with sedatives; the depressive action of ethanol on the central nervous system could be potentia... | [Alcohol-psychotropic drug interactions]. The problem of ethanol interactions with psychotropic drugs involves various factors whose complex action is examined in this article. Great care should be taken with regard to the alcohol consumption among patients treated with sedatives; the depressive action of ethanol on th... | [
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PMID:11987 | Developmental changes in serum luteinizing hormone, follicle stimulating hormone and androgen levels in males of two inbred mouse strains. | A comprehensive developmental study of serum LH, FSH and androgen concentrations was carried out in male mice of two inbred strains. Gonadotropic hormone (GTH) levels rose 10-15 days prior to the pubertal increase in serum androgen with FSH preceding LH in this regard. In both strains GTH titer rose to a peak at 30 or ... | Developmental changes in serum luteinizing hormone, follicle stimulating hormone and androgen levels in males of two inbred mouse strains. A comprehensive developmental study of serum LH, FSH and androgen concentrations was carried out in male mice of two inbred strains. Gonadotropic hormone (GTH) levels rose 10-15 day... | [
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PMID:11988 | Corticotropin releasing factor distribution in normal and Brattleboro rat brain, and effect of deafferentation, hypophysectomy and steroid treatment in normal animals. | Corticotropin-Releasing Factor (CRF) activity was determined (dispersed pituitary cell assay) in rat median eminence (ME), various hypothalamic nuclei, as well as in entire median basal hypothalamus (MBH) and extra-hypothalamic areas. Highest concentrations were seen in ME, with decreased concentrations noted proceedin... | Corticotropin releasing factor distribution in normal and Brattleboro rat brain, and effect of deafferentation, hypophysectomy and steroid treatment in normal animals. Corticotropin-Releasing Factor (CRF) activity was determined (dispersed pituitary cell assay) in rat median eminence (ME), various hypothalamic nuclei, ... | [
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PMID:11989 | The insulin receptor of the turkey erythrocyte: similarity to mammalian insulin receptors. | Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian insulin receptors. The affinity for porcine insulin was identical for the turkey and mammalian receptors over the entire range of insulin concentrations, as was the affinity of ... | The insulin receptor of the turkey erythrocyte: similarity to mammalian insulin receptors. Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian insulin receptors. The affinity for porcine insulin was identical for the turkey and m... | [
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PMID:11990 | Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin. | In vitro addition of rat insulin (200, 400 or 800 muU/ml) to collagenase-isolated pancreatic islets of adult rats diminished glucose (3 mg/ml)-induced insulin release which was correlated with a decrease of the ratio of total NADPH/NADP and inhibition of glucose oxidation via the pentose phosphate shunt (PPS). NADH and... | Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin. In vitro addition of rat insulin (200, 400 or 800 muU/ml) to collagenase-isolated pancreatic islets of adult rats diminished glucose (3 mg/ml)-induced insulin release which was correlated with a decrease of the ratio of... | [
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PMID:11991 | Binding of nuclear triiodothyronine (T3) binding protein-T3 complex to chromatin. | Nuclear tirrodothyronine (T3) binding protein (NTBP)-T3 complex, prepared from liver nuclei of rats given [125I]T3 in vovo, rebinds to rat nuclear chromatin at pH 7.4 and at low, but not high, KCl concentrations. Liver NTBP-T3 complex binds to chromatin from liver, kidney, heart, brain, testis, and spleen. Binding was ... | Binding of nuclear triiodothyronine (T3) binding protein-T3 complex to chromatin. Nuclear tirrodothyronine (T3) binding protein (NTBP)-T3 complex, prepared from liver nuclei of rats given [125I]T3 in vovo, rebinds to rat nuclear chromatin at pH 7.4 and at low, but not high, KCl concentrations. Liver NTBP-T3 complex bin... | [
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PMID:11992 | Teratopsychogenetic effects apparently produced by nonphysiological neurotransmitter concentrations during brain differentiation. | In male rats treated with pargyline, reserpine or pyridostigmine during neonatal life significant permanent changes of sexual behaviour and conditioned learning behaviour were observed in juvenile and/or adult life. Male sexual activity and learning capacity were permanently decreased in neonatally pargyline- or reserp... | Teratopsychogenetic effects apparently produced by nonphysiological neurotransmitter concentrations during brain differentiation. In male rats treated with pargyline, reserpine or pyridostigmine during neonatal life significant permanent changes of sexual behaviour and conditioned learning behaviour were observed in ju... | [
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PMID:11993 | [Plasma testosterone values in patients with somatosexual development disturbances from 11 years old to adulthood]. | The testosterone plasma level was determined in 5 groups: 1. in 69 normal juveniles and 85 fertile males at the age of 11 to 45 years, 2. in 42 patients with hypospadia or epispadia aged 11 to 25 years, 3. in 72 males with unilateral cryptorchidism at the age of 11 to 45 years, 4. in 83 males with bilateral cryptorchid... | [Plasma testosterone values in patients with somatosexual development disturbances from 11 years old to adulthood]. The testosterone plasma level was determined in 5 groups: 1. in 69 normal juveniles and 85 fertile males at the age of 11 to 45 years, 2. in 42 patients with hypospadia or epispadia aged 11 to 25 years, 3... | [
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PMID:11995 | In vivo measurements of oxyhaemoglobin saturation by a fiberoptic catheter. The effects of variations in pH and haematocrit. | The development of plastic fiberoptic catheters, cheaper and less fragile than glass ones, has enabled the more widespread use of oxyhaemoglobin saturation (SO2) monitoring. They allow direct determinations of SO2 to be made, using reflection spectrophotometry. The purpose of the present work was to evaluate the accura... | In vivo measurements of oxyhaemoglobin saturation by a fiberoptic catheter. The effects of variations in pH and haematocrit. The development of plastic fiberoptic catheters, cheaper and less fragile than glass ones, has enabled the more widespread use of oxyhaemoglobin saturation (SO2) monitoring. They allow direct det... | [
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PMID:11996 | The action of bombesin on gastric secretion of the chicken. | The natural tetradecapeptide bombesin at a threshold dose of 3--5 ng/kg/min i.v. stimulates gastric secretion in the chicken with either an acute or a chronic proventriculus fistula; this effect is blocked by atropine. The occurrence of tachyphylaxis in the acute, but not in the chronic preparation, and the inhibition ... | The action of bombesin on gastric secretion of the chicken. The natural tetradecapeptide bombesin at a threshold dose of 3--5 ng/kg/min i.v. stimulates gastric secretion in the chicken with either an acute or a chronic proventriculus fistula; this effect is blocked by atropine. The occurrence of tachyphylaxis in the ac... | [
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PMID:11997 | Further evidence implicating E-type prostaglandins in the patency of the lamb ductus arteriosus. | A blocker of prostaglandin (PG) snythesis, indomethacin, given to pregnant ewes near term produces constriction of the lamb ductus arteriosus in utero. The result supports the hypothesis formulated previously that E-type prostaglandins, which are potent relaxant on the ductus, are responsible for maintaining the patenc... | Further evidence implicating E-type prostaglandins in the patency of the lamb ductus arteriosus. A blocker of prostaglandin (PG) snythesis, indomethacin, given to pregnant ewes near term produces constriction of the lamb ductus arteriosus in utero. The result supports the hypothesis formulated previously that E-type pr... | [
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PMID:11998 | A comparison of the actions of ICI66082 and propranolol on cardiac and peripheral beta-adrenoceptors. | The relative blocking potencies of ICI66082 and propranolol with respect to heart rate contractility, diastolic blood pressure and peripheral vascular conductance were compared in anaesthetized dogs. Peripheral blood flow was measured with an electromagnetic flow-probe around the descending aorta with retrograde cannul... | A comparison of the actions of ICI66082 and propranolol on cardiac and peripheral beta-adrenoceptors. The relative blocking potencies of ICI66082 and propranolol with respect to heart rate contractility, diastolic blood pressure and peripheral vascular conductance were compared in anaesthetized dogs. Peripheral blood f... | [
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PMID:11999 | Effect of propranolol on antinociceptive, tolerance- and dependence-producing properties of morphine in rodents and monkeys. | Since an abstinence syndrome may accompany the injection of opioids in addicts pretreated with propranolol the morphine antagonistic properties of this compound were investigated. Racemic propranolol did not significantly affect the antinociceptive ED50 of morphine in rodents and neither precipitated abstinence in morp... | Effect of propranolol on antinociceptive, tolerance- and dependence-producing properties of morphine in rodents and monkeys. Since an abstinence syndrome may accompany the injection of opioids in addicts pretreated with propranolol the morphine antagonistic properties of this compound were investigated. Racemic propran... | [
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PMID:12000 | Separate receptors mediating the positive inotropic and chronotropic effect of histamine in guinea-pig atria. | The direct positive inotropic effect of histamine was studied on paced left atrial preparation from guinea pigs. Histamine (10(-8) to 10(-4) M) increased the maximum tension developed in left atria incubated at 35degreesC and driven at 2 Hz. The maximum increase in tension was 60% of that observed with norepinephrine. ... | Separate receptors mediating the positive inotropic and chronotropic effect of histamine in guinea-pig atria. The direct positive inotropic effect of histamine was studied on paced left atrial preparation from guinea pigs. Histamine (10(-8) to 10(-4) M) increased the maximum tension developed in left atria incubated at... | [
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PMID:12027 | The effects of altering the pH of seminal fluid on the sex ratio of rabbit offspring. | It has been suggested that the pH of the vagina at the time of fertilization may have a differential effect on X- or Y-bearing sperm and thereby affect the sex of the offspring. To test this postulate, rabbit semen was collected, diluted 1:10 with a buffer of pH 5.4, 6.9, or 9.6, and after 20 minutes 0.5 ml of semen-bu... | The effects of altering the pH of seminal fluid on the sex ratio of rabbit offspring. It has been suggested that the pH of the vagina at the time of fertilization may have a differential effect on X- or Y-bearing sperm and thereby affect the sex of the offspring. To test this postulate, rabbit semen was collected, dilu... | [
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PMID:12062 | Properties of prostaglandin F2alpha receptors in bovine corpus luteum cell membranes. | The specific binding of 3H-labeled prostaglandin (PG) F2alpha to bovine corpus luteum cell membranes was a rapid (K1=1.1 X 10(4) M(-1)S(-1) and reversible (K(-1)=3.3 X 10(-4) S(-1)) process at 22 degrees C. The specific binding was also a saturable process exhibiting two classes of receptors with apparent dissociation ... | Properties of prostaglandin F2alpha receptors in bovine corpus luteum cell membranes. The specific binding of 3H-labeled prostaglandin (PG) F2alpha to bovine corpus luteum cell membranes was a rapid (K1=1.1 X 10(4) M(-1)S(-1) and reversible (K(-1)=3.3 X 10(-4) S(-1)) process at 22 degrees C. The specific binding was al... | [
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PMID:12063 | Isozyme patterns of branched-chain amino acid transminase in cultured Morris hepatoma 7316A. | Cultured cells from Morris hepatoma 7316A contained isozymes I and II, but not isozyme III, of branched-chain amino acid transaminase. They also contained tyrosine transaminase. Isozyme II and tyrosine transaminase were induced by addition of cortisol. These findings agree well with in vivo findings. However, prolonged... | Isozyme patterns of branched-chain amino acid transminase in cultured Morris hepatoma 7316A. Cultured cells from Morris hepatoma 7316A contained isozymes I and II, but not isozyme III, of branched-chain amino acid transaminase. They also contained tyrosine transaminase. Isozyme II and tyrosine transaminase were induced... | [
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PMID:12064 | Serum gamma-glutamyl transpeptidase activity in viral hepatitis: suppression in pregnancy and by birth control pills. | gamma-Glutamyl transpeptidase (GGT) activity in serum was increased in the majority of women with viral hepatitis occurring in the first half of pregnancy. By contrast, GGT activity was abnormal less frequently and the mean value was relatively depressed, even though hepatitis was as severe, in the second half of gesta... | Serum gamma-glutamyl transpeptidase activity in viral hepatitis: suppression in pregnancy and by birth control pills. gamma-Glutamyl transpeptidase (GGT) activity in serum was increased in the majority of women with viral hepatitis occurring in the first half of pregnancy. By contrast, GGT activity was abnormal less fr... | [
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PMID:12065 | [Effect of O-methylhydroxylamine on extracellular phage cd]. | Study was made of lethal and mutagenic effect of 1 M and 0,5 M O-methylhydroxylamine (OMHA) on extracellular phage Sd. The correlation between chemical changes of the genome and the degree of phage inactivation under the action of OMHA has been established within the range of studied pH (4,5-7,0) of the reaction medium... | [Effect of O-methylhydroxylamine on extracellular phage cd]. Study was made of lethal and mutagenic effect of 1 M and 0,5 M O-methylhydroxylamine (OMHA) on extracellular phage Sd. The correlation between chemical changes of the genome and the degree of phage inactivation under the action of OMHA has been established wi... | [
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PMID:12067 | Blood pH: a test for assessment of severity in proctocolitis. | Acid base balance was studied in 58 patients with active idiopathic proctocolitis; the condition of 10 of them was complicated by toxic megacolon. Arterial blood pH increased progressively with increased severity of the colitis and as the lesions became more widespread. Statistically significant differences were observ... | Blood pH: a test for assessment of severity in proctocolitis. Acid base balance was studied in 58 patients with active idiopathic proctocolitis; the condition of 10 of them was complicated by toxic megacolon. Arterial blood pH increased progressively with increased severity of the colitis and as the lesions became more... | [
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PMID:12068 | Relationships between mucosal hydrolysis and transport of two phenylalanine dipeptides. | In order to investigate the source of free amino acids found in the gut lumen during absorption of dipeptides, as well as evaluating the role of brush border peptidases in the mucosal hydrolysis of dipeptides during absorption, rates of dipeptide disappearance and appearance of hydrolytic products were measured during ... | Relationships between mucosal hydrolysis and transport of two phenylalanine dipeptides. In order to investigate the source of free amino acids found in the gut lumen during absorption of dipeptides, as well as evaluating the role of brush border peptidases in the mucosal hydrolysis of dipeptides during absorption, rate... | [
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PMID:12069 | Effect of metiamide on basal and stimulated serum cholecystokinin levels in duodenal ulcer patients. | Serum cholecystokinin (CCK) levels were measured in 10 patients with chronic duodenal ulcers, fasting and at intervals after two standard tests meals (300 ml of 40 mmol/1 phenylalanine solution), one given before and one during H2-receptor blockade with metiamide (200 mg four times a day). Fasting serum CCK levels wer... | Effect of metiamide on basal and stimulated serum cholecystokinin levels in duodenal ulcer patients. Serum cholecystokinin (CCK) levels were measured in 10 patients with chronic duodenal ulcers, fasting and at intervals after two standard tests meals (300 ml of 40 mmol/1 phenylalanine solution), one given before and o... | [
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PMID:12070 | Reversible norepinephrine binding to rabbit myometrium: relationship to sites of known biological significance. | Catecholamines bind specifically to several cell types and subcellular fractions. This binding is not consistent with binding to the adrenergic receptor. Catecholamines would be expected to bind to sites other than the adrenergic receptor (uptake 1, uptake 2, nerve vesicles, catecholamine-O-methyl transferase and serum... | Reversible norepinephrine binding to rabbit myometrium: relationship to sites of known biological significance. Catecholamines bind specifically to several cell types and subcellular fractions. This binding is not consistent with binding to the adrenergic receptor. Catecholamines would be expected to bind to sites othe... | [
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PMID:12071 | Occurrence of C1 inactivator and other proteinase inhibitors in euglobulin fractions and their influence on fibrinolytic activity. | Considerable amounts of C1 inactivator and inter-alpha-trypsin inhibitor pecipitate during euglobulin fractionation of human plasma. The amount precipitated depends on the ionic strength and the pH during the fractionation procedure. In contrast, alpha1-anti-trypsin, alpha2-macroglobulinand antithrombin II are present ... | Occurrence of C1 inactivator and other proteinase inhibitors in euglobulin fractions and their influence on fibrinolytic activity. Considerable amounts of C1 inactivator and inter-alpha-trypsin inhibitor pecipitate during euglobulin fractionation of human plasma. The amount precipitated depends on the ionic strength an... | [
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PMID:12072 | Studies on the dynamics and mechanism of glibenclamide-induced insulin secretion. | Sustained, 60-minute perfusion of glibenclamide (0.5, 1.5 and 10 mug/ml) elicits a one-phase insulin release profile, formed by a rapid secretion peak followed by a second peak with lower insulin levels than the former. Basal insulin secretion values are observed during the period comprised between 13 and 60 minutes of... | Studies on the dynamics and mechanism of glibenclamide-induced insulin secretion. Sustained, 60-minute perfusion of glibenclamide (0.5, 1.5 and 10 mug/ml) elicits a one-phase insulin release profile, formed by a rapid secretion peak followed by a second peak with lower insulin levels than the former. Basal insulin secr... | [
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PMID:12073 | Plasma testosterone in prepubertal cryptorchid boys under long-term HCG therapy. | Plasma testosterone concentrations were determined before and after 6 weeks of human chorionic gonadotropin treatment in 36 prepubertal boys with bilateral or unilateral cryptorchidism. Mean +/- SD basal and post-treatment values (ng/100 ml) in the bilateral group were: treatment successful (n = 14): 32 +/- 19 and 302 ... | Plasma testosterone in prepubertal cryptorchid boys under long-term HCG therapy. Plasma testosterone concentrations were determined before and after 6 weeks of human chorionic gonadotropin treatment in 36 prepubertal boys with bilateral or unilateral cryptorchidism. Mean +/- SD basal and post-treatment values (ng/100 m... | [
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PMID:12074 | Effects of D-glyceraldehyde and 3-o-methylglucose upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets. | In perfused pancreatic islets, the fluorescence of reduced pyridine nucleotides was recorded continuously, D-Glyceraldehyde (5 mM) or 3-o-methylglucose (27.5 mM) never caused a net fluorescence increase. Since stepwise changes of the D-glucose concentration between 0 and 20 mM always induced a fluorescence increase, it... | Effects of D-glyceraldehyde and 3-o-methylglucose upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets. In perfused pancreatic islets, the fluorescence of reduced pyridine nucleotides was recorded continuously, D-Glyceraldehyde (5 mM) or 3-o-methylglucose (27.5 mM) never caused a ... | [
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PMID:12075 | Peptidase inactivation of hypothalamic releasing hormones. | With the structural characterization of the hypothalamic hormones, luteinizing hormone-releasing hormone (LH-RH), thyrotrophin-releasing (TRH), melanocyte-stimulating hormone release-inhibiting hormine (MIH), and growth hormone release-inhibiting hormone, (GH-RIH or somatostatin), it has been possible to investigate th... | Peptidase inactivation of hypothalamic releasing hormones. With the structural characterization of the hypothalamic hormones, luteinizing hormone-releasing hormone (LH-RH), thyrotrophin-releasing (TRH), melanocyte-stimulating hormone release-inhibiting hormine (MIH), and growth hormone release-inhibiting hormone, (GH-R... | [
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PMID:12076 | [The biosynthesis of glutathione in human erythrocytes (author's transl)]. | The concentrations of glutathione precursors in human erythrocytes were investigated. 300muM glutamate, 375 muM glycine, and 10muM cysteine were found by automated amino acid analysis. The concentration of 2-aminobutyrate, the precursor of ophthalmic acid, was 15muM. The influence of the activities of endogenous or add... | [The biosynthesis of glutathione in human erythrocytes (author's transl)]. The concentrations of glutathione precursors in human erythrocytes were investigated. 300muM glutamate, 375 muM glycine, and 10muM cysteine were found by automated amino acid analysis. The concentration of 2-aminobutyrate, the precursor of ophth... | [
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PMID:12077 | [Does a modified gamma-glutamyl cycle exist in human erythrocytes (author's transl)]. | The first step in the biosynthesis of glutathione is the formation of gamma-glutamyl-cysteine by the enzyme glutamyl-cysteine synthetase. Since this enzyme is not specific for cysteine, different gamma-glutamylamino acids may be formed in vivo which represent potential substrates for the enzymes gamma-glutamylcyclotran... | [Does a modified gamma-glutamyl cycle exist in human erythrocytes (author's transl)]. The first step in the biosynthesis of glutathione is the formation of gamma-glutamyl-cysteine by the enzyme glutamyl-cysteine synthetase. Since this enzyme is not specific for cysteine, different gamma-glutamylamino acids may be forme... | [
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PMID:12079 | [Carcinogenic polycyclic aromatic hydrocarbons in petroleum products: possible prevention of mineral oil cancer]. | A real epidemy of cutaneous cancer has appeared from 1954 in a french area specialized in the metal machining industry (valley of the Arve, Haute-Saoie). Two investigations have been carried out: - one, of clinical and epidemiological nature over a period of 15 years, has recorded 133 casesof spinocellular epitheliams ... | [Carcinogenic polycyclic aromatic hydrocarbons in petroleum products: possible prevention of mineral oil cancer]. A real epidemy of cutaneous cancer has appeared from 1954 in a french area specialized in the metal machining industry (valley of the Arve, Haute-Saoie). Two investigations have been carried out: - one, of ... | [
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PMID:12080 | Radiation cancer, safety standards and current levels of exposure. | Cancer can be induced by radiation in any tissue where cancer occurs naturally. The observation that antenatal diagnostic radiography causes a small but definit increas in childhood cancer is as good evidence as could be expected in support of the scientific expectation that there would be no threshold of dose for carc... | Radiation cancer, safety standards and current levels of exposure. Cancer can be induced by radiation in any tissue where cancer occurs naturally. The observation that antenatal diagnostic radiography causes a small but definit increas in childhood cancer is as good evidence as could be expected in support of the scien... | [
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PMID:12081 | [Epidemiological aspects in carcinogenic risk evaluation arising from pollution]. | Descriptive epidemiology in which population groups are studied can be of considerable value in drawing attention to a potential carcinogen. This must be followed by analytical studies which might either lead with a fair degree of certainty to the identification of the responsible factor or at least help to identify th... | [Epidemiological aspects in carcinogenic risk evaluation arising from pollution]. Descriptive epidemiology in which population groups are studied can be of considerable value in drawing attention to a potential carcinogen. This must be followed by analytical studies which might either lead with a fair degree of certain... | [
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PMID:12084 | Effect of thiocyanate on nitrite estimation and the cleavage of nitrosamines. | Thiocyanate or bromide increased the colour formed by nitrite reacting with sulfanilic acid and naphthylethylenediamine. If the colour reagents were added together with thiocyanate (final concentration, M/10), the colour intensity was doubled. If sulfanilic acid was added three minutes before addition of naphthylethyle... | Effect of thiocyanate on nitrite estimation and the cleavage of nitrosamines. Thiocyanate or bromide increased the colour formed by nitrite reacting with sulfanilic acid and naphthylethylenediamine. If the colour reagents were added together with thiocyanate (final concentration, M/10), the colour intensity was doubled... | [
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PMID:12085 | Effects of gallic acid and of ethanol on formation of nitrosodiethylamine. | In vitro experiments demonstrate that the polyphenol, gallic acid, can both catalyse and inhibit NDEA formation. The products of reaction depend considerably on pH conditions and relative concentrations of the reactants. Therefore, interpretation of in vitro experiments in terms of possible in vivo effects in a given p... | Effects of gallic acid and of ethanol on formation of nitrosodiethylamine. In vitro experiments demonstrate that the polyphenol, gallic acid, can both catalyse and inhibit NDEA formation. The products of reaction depend considerably on pH conditions and relative concentrations of the reactants. Therefore, interpretatio... | [
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PMID:12090 | Effects of some inhibitors on the nitrosation of drugs in human gastric juice. | The nitrosation of several drugs under simulated stomach conditions was only weakly inhibited by the beverages studied. With easily and rapidly nitrosatable drugs, such as aminophenazone or piperazine, administered orally, the use of an inhibitor of nitrosation is to be recommended. Of all the substances investigated, ... | Effects of some inhibitors on the nitrosation of drugs in human gastric juice. The nitrosation of several drugs under simulated stomach conditions was only weakly inhibited by the beverages studied. With easily and rapidly nitrosatable drugs, such as aminophenazone or piperazine, administered orally, the use of an inhi... | [
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PMID:12092 | Chemical studies on tobacco smoke. XLII. Nitrosonornicotine: presence in tobacco, formation and carcinogenicity. | NNN is the first organic carcinogen isolated from unburned tobacco. It has been found in smoking tobaccos, chewing tobaccos and in snuff in concentrations between 0.3 and 90.0 mug. This appears to be an unusually high concentration for a nitrosamine in an environmental agent. We have presented data which suggest that N... | Chemical studies on tobacco smoke. XLII. Nitrosonornicotine: presence in tobacco, formation and carcinogenicity. NNN is the first organic carcinogen isolated from unburned tobacco. It has been found in smoking tobaccos, chewing tobaccos and in snuff in concentrations between 0.3 and 90.0 mug. This appears to be an unus... | [
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PMID:12111 | Microbicidal mechanisms of human granulocytes: synergistic effects of granulocyte elastase and myeloperoxidase or chymotrypsin-like cationic protein. | The antibacterial activity of a myeloperoxidase (MPO)-glucose oxidase system was found to be greatly increased by granulocyte elastase, present in azurophil granules of human neutrophils. The MPO-H2O3-mediated killing of both Escherichia coli and Staphylococcus aureus was potentiated by granuocyte elastase at an acid p... | Microbicidal mechanisms of human granulocytes: synergistic effects of granulocyte elastase and myeloperoxidase or chymotrypsin-like cationic protein. The antibacterial activity of a myeloperoxidase (MPO)-glucose oxidase system was found to be greatly increased by granulocyte elastase, present in azurophil granules of h... | [
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PMID:12113 | Effect of bromazepam on gastric acid secretion related to hypnotically induced anxiety. | The effects of bromazepam (0.1 mg/kg b.w. i.v.) and of placebo on gastric acid secretion related to hypnotically induced anxiety were evaluated in a double blind study, 22 experiments were carried out on 4 healthy volunteers. Drugs were injected after one basal hour. Hypnosis was induced immediately thereafter, and a s... | Effect of bromazepam on gastric acid secretion related to hypnotically induced anxiety. The effects of bromazepam (0.1 mg/kg b.w. i.v.) and of placebo on gastric acid secretion related to hypnotically induced anxiety were evaluated in a double blind study, 22 experiments were carried out on 4 healthy volunteers. Drugs ... | [
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PMID:12114 | [Effect of fominoben on ventilation, oxygen uptake and blood gases in patients with obstructive ventilation disorders]. | The substituted benzylamin-derivative fominoben (PB 89 Noleptan) was intravenously administered to 12 patients with chronic obstructive lung disease in order to determine, whether an analeptic action on respiration, which had been found by others in animal studies and in healthy subjects, can also be demonstrated in pa... | [Effect of fominoben on ventilation, oxygen uptake and blood gases in patients with obstructive ventilation disorders]. The substituted benzylamin-derivative fominoben (PB 89 Noleptan) was intravenously administered to 12 patients with chronic obstructive lung disease in order to determine, whether an analeptic action ... | [
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PMID:12115 | Antihypertensive effect of labetalol, a new alpha- and beta-adrenergic blocking agent. | Labetalol (AH5158) a new alpha- and beta-adrenergic blocking agent was given to 12 hypertensive patients for an average of 7 months. Statistically significant and clinically relevant reductions of blood pressure both in the recumbent and standing positions were observed. Side effects were few and the absence of postura... | Antihypertensive effect of labetalol, a new alpha- and beta-adrenergic blocking agent. Labetalol (AH5158) a new alpha- and beta-adrenergic blocking agent was given to 12 hypertensive patients for an average of 7 months. Statistically significant and clinically relevant reductions of blood pressure both in the recumbent... | [
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PMID:12116 | Preliminary experience with vascularised Fallopian tube transplants in the human female. | The preoperative screening and postoperative case records of two patients that underwent vascularised Fallopian tube transplants are described. In both cases the operation was followed by immunological rejection. This was chronic and clinically quiescent in the first patient, but an accelerated rejection associated wit... | Preliminary experience with vascularised Fallopian tube transplants in the human female. The preoperative screening and postoperative case records of two patients that underwent vascularised Fallopian tube transplants are described. In both cases the operation was followed by immunological rejection. This was chronic a... | [
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PMID:12117 | Completed pregnancy following vascularized heterotopic autotransplantation of the Fallopian tube in the ewe. | Transplantation of the Fallopian tube is a technically feasible operation. Previous authors have reported pregnancies following turbo-ovarian transplants, but there appears to be no record of gestation following transplantation of the isolated oviduct. This communication illustrates the method that we have used to perf... | Completed pregnancy following vascularized heterotopic autotransplantation of the Fallopian tube in the ewe. Transplantation of the Fallopian tube is a technically feasible operation. Previous authors have reported pregnancies following turbo-ovarian transplants, but there appears to be no record of gestation following... | [
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PMID:12118 | Hormone-receptor interactions--basic mechanisms. | An understanding of the basic mechanisms of hormone action is becoming an important part of a clinician's training. With the advent of radioreceptor assays and their comparison with radioimmunoassays, we are becoming increasingly aware that the normal physiological function of a hormone is not necessarily dependent on ... | Hormone-receptor interactions--basic mechanisms. An understanding of the basic mechanisms of hormone action is becoming an important part of a clinician's training. With the advent of radioreceptor assays and their comparison with radioimmunoassays, we are becoming increasingly aware that the normal physiological funct... | [
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PMID:12119 | Effect of caffeine on the motility, viability, oxygen consumption and glycolytic rate of ejaculated human normokinetic and hypokinetic spermatozoa. | In this report the effect of caffeine, IBMX and Cholera toxin on ejaculated human spermatozoa was tested. It was found that caffeine was the most effective drug, and that Cholera toxin was ineffective. Caffeine stimulated motility, preserved viability and increased the glucose, fructose utilization and lactate producti... | Effect of caffeine on the motility, viability, oxygen consumption and glycolytic rate of ejaculated human normokinetic and hypokinetic spermatozoa. In this report the effect of caffeine, IBMX and Cholera toxin on ejaculated human spermatozoa was tested. It was found that caffeine was the most effective drug, and that C... | [
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... |
PMID:12120 | Blastoid transformation of lymphocytes in response to spermatozoa. | Microlymphocyte transformation tests were done on 33 female rabbits immunized with different components of rabbit ejaculate. In rabbits injected with total ejaculate or washed spermatozoa a specific stimulation of lymphocytes could be demonstrated by exposure to washed spermatozoa. It is shown that it is necessary to n... | Blastoid transformation of lymphocytes in response to spermatozoa. Microlymphocyte transformation tests were done on 33 female rabbits immunized with different components of rabbit ejaculate. In rabbits injected with total ejaculate or washed spermatozoa a specific stimulation of lymphocytes could be demonstrated by ex... | [
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PMID:12121 | GPC diesterase activity in human endometrial secretion. (Its variations under the action of estrogens, clomiphene citrate, D-norgestrel (post-coital and low dose) and intrauterine device (IUD).) | Diesterase activity was studied in human uterine secretions of normal women and in those under treatment for sterility or contraception. Endometrial secretions were obtained from 78 patients and the material divided into four groups: normal women, under different estrogens; with D-Norgestrel treatment (daily and post-c... | GPC diesterase activity in human endometrial secretion. (Its variations under the action of estrogens, clomiphene citrate, D-norgestrel (post-coital and low dose) and intrauterine device (IUD).). Diesterase activity was studied in human uterine secretions of normal women and in those under treatment for sterility or co... | [
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