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PMID:15632 | [Catalytic properties of a neutral alpha-glucosidase from human kidney]. | The catalytic properties of a neutral alpha-glucosidase purified to homogeneity from human renal cortex are described. The pH optimum was 6 (maltose and starch). It has a broad range of substrate specificity, hydrolysing di- and oligosaccharides with alpha (1 leads to 2), alpha (1 leads to 3), alpha (1 leads to 4) and ... | [Catalytic properties of a neutral alpha-glucosidase from human kidney]. The catalytic properties of a neutral alpha-glucosidase purified to homogeneity from human renal cortex are described. The pH optimum was 6 (maltose and starch). It has a broad range of substrate specificity, hydrolysing di- and oligosaccharides w... | [
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PMID:15633 | Structural glycoprotein from the media of pig aorta. Aggregation of the S-carboxamidomethyl subunits. | Media of pig aorta was extracted with 1 M NaCl and 2 M MgCl2 to remove most of the soluble collagen, proteoglycans and glycoproteins. The glycoproteins remaining in the residue were extracted with 6 M urea-0.1 M mercaptoethanol. The urea soluble proteins were precipitated by dialysis, redissolved in 4 M guanidine-0.05 ... | Structural glycoprotein from the media of pig aorta. Aggregation of the S-carboxamidomethyl subunits. Media of pig aorta was extracted with 1 M NaCl and 2 M MgCl2 to remove most of the soluble collagen, proteoglycans and glycoproteins. The glycoproteins remaining in the residue were extracted with 6 M urea-0.1 M mercap... | [
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PMID:15634 | Interaction between photoperiod, temperature, and chilling in dormant larvae of the tree-hole mosquito, Toxorhynchites rutilus Coq. | 1. Unchilled, diapausing larvae of Toxorhynchites rutilus rely on photoperiod for the maintenance of diapause. The photoperiodic clock is temperature-compensated between 16.5 degrees and 25 degrees C, maintaining both a similar set-joint and inherent accuracy over this range. The rates of development among larvae termi... | Interaction between photoperiod, temperature, and chilling in dormant larvae of the tree-hole mosquito, Toxorhynchites rutilus Coq. 1. Unchilled, diapausing larvae of Toxorhynchites rutilus rely on photoperiod for the maintenance of diapause. The photoperiodic clock is temperature-compensated between 16.5 degrees and 2... | [
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PMID:15635 | The ontogeny of swimming behavior in the scyphozoan, Aurelia aurita. I. Electrophysiological analysis. | 1. Electrical correlates of behavioral activity were observed in the lip and tentacles of the polyp, but none were detected during column contraction. The tentacles are the most electrically active tissue, and the potentials are conducted along the length of the tentacle, but conduction to other parts of the animal wer... | The ontogeny of swimming behavior in the scyphozoan, Aurelia aurita. I. Electrophysiological analysis. 1. Electrical correlates of behavioral activity were observed in the lip and tentacles of the polyp, but none were detected during column contraction. The tentacles are the most electrically active tissue, and the pot... | [
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PMID:15636 | The ontogeny of swimming behavior in the scyphozoan, Aurelia aurita. II. The effects of ions and drugs. | 1. The responses of Aurelia medusae to pharmacological agents and ionic variation were classified into four response types: Type I, no response; Type II, inhibition of pacemaker activity; Type III, inhibition of both pacemakers and swimming muscles; and Type IV, increase in pacemaker output. 2. The swimming pacemakers ... | The ontogeny of swimming behavior in the scyphozoan, Aurelia aurita. II. The effects of ions and drugs. 1. The responses of Aurelia medusae to pharmacological agents and ionic variation were classified into four response types: Type I, no response; Type II, inhibition of pacemaker activity; Type III, inhibition of both... | [
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PMID:15637 | [Isolation of individual proteases from protofradin]. | An electrophoretically homogeneous trypsin-like proteinase, two homogeneous proteases (presumably metal-containing) and two elastases, possessing the ATEE-esterase activity, were isolated from protofradin, a protease preparation from Actinomyces fradiae 119, using fractionation on KM-cellulose K-32. The trypsin like pr... | [Isolation of individual proteases from protofradin]. An electrophoretically homogeneous trypsin-like proteinase, two homogeneous proteases (presumably metal-containing) and two elastases, possessing the ATEE-esterase activity, were isolated from protofradin, a protease preparation from Actinomyces fradiae 119, using f... | [
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PMID:15638 | [Metal proteases from Bac. subtilis]. | Metal and serine proteases were separated on the biospecific sorbent. Two different, homogeneous metal proteases were obtained by rechromatography of the metal protease. Activation energies, heat stability, molecular weights, influence of inhibitors, the dependence of activity on pH and temperature were determined. Pro... | [Metal proteases from Bac. subtilis]. Metal and serine proteases were separated on the biospecific sorbent. Two different, homogeneous metal proteases were obtained by rechromatography of the metal protease. Activation energies, heat stability, molecular weights, influence of inhibitors, the dependence of activity on p... | [
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PMID:15639 | [Purification and properties of peroxidase from tea leaves]. | Purification of fractions of tea leaves peroxidase is described. During ion-exchange chromatography on DEAE- and CM-cellulose peroxidase is eluted into six fractions, differing in their electrophoretic properties. The enzyme showed optimal activity at pH 4.1-5.0, when the enzyme fractions of guaiacol adsorbed on DEAE-c... | [Purification and properties of peroxidase from tea leaves]. Purification of fractions of tea leaves peroxidase is described. During ion-exchange chromatography on DEAE- and CM-cellulose peroxidase is eluted into six fractions, differing in their electrophoretic properties. The enzyme showed optimal activity at pH 4.1-... | [
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PMID:15640 | [Isolation, purification and investigation of physico-chemical properties and specificity of Leu-Gly-Gly-amino peptidase]. | A highly purified (237-fold) preparation of extracellular Leu-Gly-Gly aminopeptidase was isolated from the 716 strain of mould Aspergillis flavus. The enzyme was found electrophoretically and enzymatically homogeneous, using Leu-beta-naphthylimide as substrate. The pH optimum is 8.60; the temperature optimum is about 5... | [Isolation, purification and investigation of physico-chemical properties and specificity of Leu-Gly-Gly-amino peptidase]. A highly purified (237-fold) preparation of extracellular Leu-Gly-Gly aminopeptidase was isolated from the 716 strain of mould Aspergillis flavus. The enzyme was found electrophoretically and enzym... | [
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PMID:15641 | [Study of the initial reaction of enzymatic oxidation of 1,8-dimethylnaphthalene]. | Crude enzymatic preparation has been obtained from Pseudomonas bacteria which oxidises 1,8-DMN during 10-hour incubation with the following formation of the same products which are formed when this compound is oxidized by the intact cells. The first product of the oxidation is 1-methyl-8-oxymethylnaphtalene (compound I... | [Study of the initial reaction of enzymatic oxidation of 1,8-dimethylnaphthalene]. Crude enzymatic preparation has been obtained from Pseudomonas bacteria which oxidises 1,8-DMN during 10-hour incubation with the following formation of the same products which are formed when this compound is oxidized by the intact cell... | [
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PMID:15642 | [Purification of hirudin by the method of isoelectric focusing]. | Crude hirudin preparation was purified by isoelectric focussing in pH gradient 3-5. The presence of at least two active isoforms with pI 3.8 and 3.9 was demonstrated. The component with pI value of 3.9 possessed the specific activity as high as 8200 NIH AT units/mg. | [Purification of hirudin by the method of isoelectric focusing]. Crude hirudin preparation was purified by isoelectric focussing in pH gradient 3-5. The presence of at least two active isoforms with pI 3.8 and 3.9 was demonstrated. The component with pI value of 3.9 possessed the specific activity as high as 8200 NIH A... | [
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PMID:15643 | [Isolation and properties of cortisol inducible and cortisol non-inducible isoenzymes of rat liver tyrosine aminotransferase]. | Rat liver contains two groups of tyrosine aminotransferase (TAT) isoenzymes; during electrophoresis in agar gel one of the groups moves to the anode and the other--to the catode. Cortisol is shown to induce only the anode isoenzymes of TAT, which were isolated, purified and thoroughly analyzed. The inducible anode isoe... | [Isolation and properties of cortisol inducible and cortisol non-inducible isoenzymes of rat liver tyrosine aminotransferase]. Rat liver contains two groups of tyrosine aminotransferase (TAT) isoenzymes; during electrophoresis in agar gel one of the groups moves to the anode and the other--to the catode. Cortisol is sh... | [
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PMID:15644 | [The relationship of cottonseed's triacetinase]. | A multiplicity of triacetinase forms in cotton seeds was studied. Three triacetinases (A, B and C) were shown to undergo reciprocal conversions under storage and during some purification procedures (effect of pH, ionic strength, ion-exchange chromatography, concentration, lyophilization, etc.). On the other hand, the p... | [The relationship of cottonseed's triacetinase]. A multiplicity of triacetinase forms in cotton seeds was studied. Three triacetinases (A, B and C) were shown to undergo reciprocal conversions under storage and during some purification procedures (effect of pH, ionic strength, ion-exchange chromatography, concentration... | [
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PMID:15645 | [Participation of the iron-containing pterine-protein complex in NADP reduction and electron transport]. | A factor of protein nature, containing pteridines and iron ions was isolated from pea leaves. The compound was shown capable of activating NADP reduction during chloroplasts illumination in the absence of ferredoxin. The compound was termed "NADP-reducing factor" (NRP). Freshly isolated NRF in combination with the prot... | [Participation of the iron-containing pterine-protein complex in NADP reduction and electron transport]. A factor of protein nature, containing pteridines and iron ions was isolated from pea leaves. The compound was shown capable of activating NADP reduction during chloroplasts illumination in the absence of ferredoxin... | [
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PMID:15646 | [Study of splitting dinucleoside monophosphates by Penicillium brevicompactum RNAse]. | In studies of splitting of transferase substrates cytidylyl-(3' leeds to 5')-adenosine and adenylyl-(3'leds to to 5')-cytidine by Penicillium brevicompactum RNAase the pH-optimum activity of enzyme has been found to fall within the range of 4.7 +/- 0;1; temperature optimum--within 41 degrees--43 degrees C; adenine-nucl... | [Study of splitting dinucleoside monophosphates by Penicillium brevicompactum RNAse]. In studies of splitting of transferase substrates cytidylyl-(3' leeds to 5')-adenosine and adenylyl-(3'leds to to 5')-cytidine by Penicillium brevicompactum RNAase the pH-optimum activity of enzyme has been found to fall within the ra... | [
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PMID:15647 | [Glutamine metabolism regulation in Chlorella pyrenoidosa. Regulation of Chlorella glutamine synthetase activity by amino acids]. | Effect of glutamine and its metabolites (amino acids) on Chlorella glutamine synthetase (GS) (E.C.6.3.1.2) in the presence of Mg or Mn was studied. Purified GS preparation was used, isolated from Chlorella grown in the presence of NH as a sole nitrogen source. Glutamate, aspartate, alanine and glycine inhibit GS activi... | [Glutamine metabolism regulation in Chlorella pyrenoidosa. Regulation of Chlorella glutamine synthetase activity by amino acids]. Effect of glutamine and its metabolites (amino acids) on Chlorella glutamine synthetase (GS) (E.C.6.3.1.2) in the presence of Mg or Mn was studied. Purified GS preparation was used, isolated... | [
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PMID:15648 | [Electrochemical gradient of H+ ions as an immediate source of energy during bacteria movement]. | An uncoupler of oxidative phosphorylation causes an instantaneous cessation of movement of bacteria Rhodospirillum rubrum in the presence and in the absence of oligomycin. It is concluded that such cessation is not due to a decrease in the ATP concentration but to the elimination of deltamicron-H+ by the uncoupler. The... | [Electrochemical gradient of H+ ions as an immediate source of energy during bacteria movement]. An uncoupler of oxidative phosphorylation causes an instantaneous cessation of movement of bacteria Rhodospirillum rubrum in the presence and in the absence of oligomycin. It is concluded that such cessation is not due to a... | [
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PMID:15649 | [Inhibitory effect platinum and palladium complexes as indicator of conformational changes in sarcoplasmic reticulum membranes]. | Inhibition of Ca2+-dependent ATPase of sarcoplasmic reticulum membranes (SRM) by platinum and palladium complexes is considerable enhanced during the incubation of these compunds with SRM preparations in the presence of small (10(-5) M) concentrations of ATP or ADP. AMP and nucleotides with non-adenine bases do not hav... | [Inhibitory effect platinum and palladium complexes as indicator of conformational changes in sarcoplasmic reticulum membranes]. Inhibition of Ca2+-dependent ATPase of sarcoplasmic reticulum membranes (SRM) by platinum and palladium complexes is considerable enhanced during the incubation of these compunds with SRM pre... | [
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PMID:15650 | [Adenine uptake in Neurospora crassa mycelium]. | The uptake of 8-C14-adenine in N. crassa strain Lindegren (+) was studied. The ability of N. crassa cells to uptake adenine from the medium reaches maximum at the very beginning of the logarithmic stage of growth. Adenine enters the mycelium against the concentration gradient. The uptake of adenine is maximal at 25-30 ... | [Adenine uptake in Neurospora crassa mycelium]. The uptake of 8-C14-adenine in N. crassa strain Lindegren (+) was studied. The ability of N. crassa cells to uptake adenine from the medium reaches maximum at the very beginning of the logarithmic stage of growth. Adenine enters the mycelium against the concentration grad... | [
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PMID:15651 | [beta-Glucosidases from fungus Geotrichum candidum]. | beta-Glucosidases from Geotrichum candidum 3C cellulase preparation were separated from C1 enzymes and beta-1,4-glucanases by means of DEAE-Sephadex A-50 chromatography, gel filtration through P-150 Biogel and chromatography on CM-cellulose, and then were fractionated by isoelectric focusing using carrier ampholites wi... | [beta-Glucosidases from fungus Geotrichum candidum]. beta-Glucosidases from Geotrichum candidum 3C cellulase preparation were separated from C1 enzymes and beta-1,4-glucanases by means of DEAE-Sephadex A-50 chromatography, gel filtration through P-150 Biogel and chromatography on CM-cellulose, and then were fractionate... | [
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PMID:15652 | [Optical and magnetic properties of azurin from Pseudomanas aeruginosa]. | Optical, fluorescence and EPR spectra of azurin from Pseudomonas aeruginosa are described. Some properties of this protein are found to be similar to those of copper-containing proteins from plants (plastocyanin and plantacyanin). The interaction of ferricyanide with azurin bleached in alkaline media results in the for... | [Optical and magnetic properties of azurin from Pseudomanas aeruginosa]. Optical, fluorescence and EPR spectra of azurin from Pseudomonas aeruginosa are described. Some properties of this protein are found to be similar to those of copper-containing proteins from plants (plastocyanin and plantacyanin). The interaction ... | [
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PMID:15653 | [Investigation of rat brain prealbumins]. | 12 prealbumines of rat brain water-soluble fraction were studied. Neither lipid components nor carbohydrate ones were found out in the proteins. Three of the proteins appeared to be RNA-proteids. Their subcellular distribution was investigated. The effects of temperature, salts, acids and ethanol on disc electrophoreti... | [Investigation of rat brain prealbumins]. 12 prealbumines of rat brain water-soluble fraction were studied. Neither lipid components nor carbohydrate ones were found out in the proteins. Three of the proteins appeared to be RNA-proteids. Their subcellular distribution was investigated. The effects of temperature, salts... | [
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PMID:15654 | [Inhibition of mouse spleen inorganic pyrophosphatase by methylene diphosphonic acid]. | Some properties of mouse spleen cytosol inorgainc pyrophosphatase (PPi-ase) (E. C. 3.6.1.1) as well as the effect of methylene diphosphonic acid (PCP) on the PPi-ase activity were studied. Specific staining for the enzyme PAAG disc-electrophoresis was developed; it was shown that the PPi-ase formed only one band in 7.5... | [Inhibition of mouse spleen inorganic pyrophosphatase by methylene diphosphonic acid]. Some properties of mouse spleen cytosol inorgainc pyrophosphatase (PPi-ase) (E. C. 3.6.1.1) as well as the effect of methylene diphosphonic acid (PCP) on the PPi-ase activity were studied. Specific staining for the enzyme PAAG disc-e... | [
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PMID:15655 | [The role of the tryptophan-62 residue in the structure and function of lysozyme]. | The thermostability and thermodinamics of formation of the enzyme-substrate complex of two oxidation products of chicken egg lysozyme with the tryptophane-62 residue modified to N'-formylkinurenine (with 2.5% activity) and kinurenine (with 27.5% activity) have been studied. In thermostability and pH effect on the subst... | [The role of the tryptophan-62 residue in the structure and function of lysozyme]. The thermostability and thermodinamics of formation of the enzyme-substrate complex of two oxidation products of chicken egg lysozyme with the tryptophane-62 residue modified to N'-formylkinurenine (with 2.5% activity) and kinurenine (wi... | [
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PMID:15656 | [Study of rat brain tissue nucleases]. | Acid and alkaline nucleases of the brain tissues have been identified and partially purified. Alkaline DNA-ase hydrolyzing denatured DNA at pH 8,0; alkaline RNA-ase having optimal activity at pH 8,0 and nuclease intensively hydrolyzing both DNA and RNA at pH 5.0. The molecular weights of these enzymes have been determi... | [Study of rat brain tissue nucleases]. Acid and alkaline nucleases of the brain tissues have been identified and partially purified. Alkaline DNA-ase hydrolyzing denatured DNA at pH 8,0; alkaline RNA-ase having optimal activity at pH 8,0 and nuclease intensively hydrolyzing both DNA and RNA at pH 5.0. The molecular wei... | [
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PMID:15657 | [Purification, properties and quaternary structure of glutamine synthetase from Chlorella]. | A highly purified preparation of glutamine synthetase from chlorella grown on a medium containing nitrate as a sole source of nitrogen, was isolated and characterized by disc-electrophoresis and analytical ultracentrifugation. The N-terminal amino acid of glutamine synthetase is glycine. The molecular weight of glutami... | [Purification, properties and quaternary structure of glutamine synthetase from Chlorella]. A highly purified preparation of glutamine synthetase from chlorella grown on a medium containing nitrate as a sole source of nitrogen, was isolated and characterized by disc-electrophoresis and analytical ultracentrifugation. T... | [
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PMID:15658 | [Some physicochemical properties of modified trypsin]. | Physico-chemical properties of trypsin covalently bound with human serum albumin by glutaric aldehyde have been studied. The modification of the enzyme practically caused no changes in the pH optimum of trypsin. The inhibition of modified trypsin by inhibitors from soy beans and human blood serum has been also studied.... | [Some physicochemical properties of modified trypsin]. Physico-chemical properties of trypsin covalently bound with human serum albumin by glutaric aldehyde have been studied. The modification of the enzyme practically caused no changes in the pH optimum of trypsin. The inhibition of modified trypsin by inhibitors from... | [
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PMID:15659 | [Fractionation and purification of endo-1,4-beta-xylanases and exo-1,4-beta-xylosidases of Aspergillus niger]. | Two endo-1,4-beta-zylanases (m. w. 24,000 and 41,000) and six exo-1,4-beta-xylosidases, differing in their molecular weights and isoelectric points, were found in a xylanase preparation from Aspergillus niger, using different methods of fractionation. An electrophoretically homogeneous exo-1,4-beta-xylosidase (m. w. 30... | [Fractionation and purification of endo-1,4-beta-xylanases and exo-1,4-beta-xylosidases of Aspergillus niger]. Two endo-1,4-beta-zylanases (m. w. 24,000 and 41,000) and six exo-1,4-beta-xylosidases, differing in their molecular weights and isoelectric points, were found in a xylanase preparation from Aspergillus niger,... | [
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PMID:15660 | [Enzymatic properties of immobilized beta-galactosidase from Curvularia inaequalis]. | beta-Galactosidase (EC 3.2.1.23) from fungus Curvularia inaequalis was modified by active brilliant orange KH and adsorbed on DEAE-Sephadex A-50. The lactose hydrolysis was studied in a continous flow on the column packed with the immobilized enzyme. The pH and temperatures optima for the substrate hydrolysis by the im... | [Enzymatic properties of immobilized beta-galactosidase from Curvularia inaequalis]. beta-Galactosidase (EC 3.2.1.23) from fungus Curvularia inaequalis was modified by active brilliant orange KH and adsorbed on DEAE-Sephadex A-50. The lactose hydrolysis was studied in a continous flow on the column packed with the immo... | [
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PMID:15661 | [Use of sedimentation under conditions of acidic denaturation for the determination of molecular weights of RNAs]. | The conditions for acidic denaturation of double stranded RNA were found. Under these conditions a limited degradation of high molecular weight viral RNA took place. This degradation was determined by the degree of fragmentation and loss of infectivity at acidic conditions. It was found that acidic denaturation of RNA ... | [Use of sedimentation under conditions of acidic denaturation for the determination of molecular weights of RNAs]. The conditions for acidic denaturation of double stranded RNA were found. Under these conditions a limited degradation of high molecular weight viral RNA took place. This degradation was determined by the ... | [
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PMID:15662 | [Purification and properties of phototrophic bacteria Thiocapsa roseopersicina hydrogenase bound with chromatophores]. | The method of solution and puridication of hydrogenase from chromatophores of purpur sulphur bacteria Thiocapsa roseopersicina strain BBS are described. Hydrogenase molecular weight is 73000. It contains 4,4 mole S2- and 3.1 mole Fe2+ per mole of protein; pI 4.15. The enzyme absorption spectrum has the maximun et 400-4... | [Purification and properties of phototrophic bacteria Thiocapsa roseopersicina hydrogenase bound with chromatophores]. The method of solution and puridication of hydrogenase from chromatophores of purpur sulphur bacteria Thiocapsa roseopersicina strain BBS are described. Hydrogenase molecular weight is 73000. It contai... | [
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PMID:15663 | [Conformation study of cyclic adenosine-3',5'-monophosphate and some of its derivatives by means of circular dichroism]. | Circular dichroism spectra of adenosine and cyclic adenosine-3',5'-monophosphate (cAMP) and their derivatives, having different substituents in 8-position of heterocycle, are studied, cAMP is suggested to have preferable anti-conformation in the solution, while its derivatives with substituents in 8-position of purine ... | [Conformation study of cyclic adenosine-3',5'-monophosphate and some of its derivatives by means of circular dichroism]. Circular dichroism spectra of adenosine and cyclic adenosine-3',5'-monophosphate (cAMP) and their derivatives, having different substituents in 8-position of heterocycle, are studied, cAMP is suggest... | [
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PMID:15665 | The relationship between epilepsy and schizophrenia: a biochemical hypothesis. | There has been much controversy in the past surrounding the relationship between schizophrenia and epilepsy. One hypothesis has been that the two disorders are antagonistic. The evidence supporting the antagonism hypothesis is briefly reviewed. A new theory based on current knowledge of the relationship of dopamine to ... | The relationship between epilepsy and schizophrenia: a biochemical hypothesis. There has been much controversy in the past surrounding the relationship between schizophrenia and epilepsy. One hypothesis has been that the two disorders are antagonistic. The evidence supporting the antagonism hypothesis is briefly review... | [
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PMID:15667 | High and low affinity Ca2+ binding to the sarcoplasmic reticulum: use of a high-affinity fluorescent calcium indicator. | The fluorescent calcium indicator, calcein, has been used as a high-affinity indicator of Ca2+ in the aqueous phase at physiological pH in the study of high-affinity calcium binding to sarcoplasmic reticulum (SR). The binding constant of the indicator at physiological pH is 10(3)-10(4) M-1 and increases with increasing... | High and low affinity Ca2+ binding to the sarcoplasmic reticulum: use of a high-affinity fluorescent calcium indicator. The fluorescent calcium indicator, calcein, has been used as a high-affinity indicator of Ca2+ in the aqueous phase at physiological pH in the study of high-affinity calcium binding to sarcoplasmic re... | [
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PMID:15668 | Structural changes and fluctuations of proteins. II. Analysis of the denaturation of globular proteins. | The statistical thermodynamic model of protein structure proposed in paper I is developed with special attention to the hydrophobic interaction. Calorimetric measurements of the thermal denaturation of five globular proteins, ribonuclease A, lysozyme, alpha-chymotrypsin, cytochrome c, and myoglobin, are quantitatively ... | Structural changes and fluctuations of proteins. II. Analysis of the denaturation of globular proteins. The statistical thermodynamic model of protein structure proposed in paper I is developed with special attention to the hydrophobic interaction. Calorimetric measurements of the thermal denaturation of five globular ... | [
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PMID:15669 | Oligonucleotide conformations. (5) NMR and relaxation studies on GpU and UpG at neutral pH. | The average conformation of GpU and UpG in neutral aqueous solutions has been investigated by proton chemical shifts and coupling measurements as well as T1 relaxation time experiments. The proportion of the N and S pseudorotational conformers of the ribose ring has been derived from the vicinal coupling constants. The... | Oligonucleotide conformations. (5) NMR and relaxation studies on GpU and UpG at neutral pH. The average conformation of GpU and UpG in neutral aqueous solutions has been investigated by proton chemical shifts and coupling measurements as well as T1 relaxation time experiments. The proportion of the N and S pseudorotati... | [
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PMID:15670 | Kinetics of the polymerization reaction of tobacco mosaic virus protein: transient-saturation type polymerization reaction. | The kinetics of the endothermic polymerization reaction of tobacco mosaic virus protein in the mild acid region was studied by means of temperature-jump (rising time of 6 sec)-turbidimetry, electron microscopy, and computer simulation. The time course profile of the turbidity increase changed from a normal one to an an... | Kinetics of the polymerization reaction of tobacco mosaic virus protein: transient-saturation type polymerization reaction. The kinetics of the endothermic polymerization reaction of tobacco mosaic virus protein in the mild acid region was studied by means of temperature-jump (rising time of 6 sec)-turbidimetry, electr... | [
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PMID:15671 | Our present knowledge of calcium or hydrogen ions as transmitters in the vertebrate rod outer segments. | Difficulties in testing the possible role of calcium as a Transmitter in the R.O.S. are discussed. A comparison is made with the Sarcoplasmic Reticulum system where calcium flux are easily measured. The latest results reviewed on intact cellular structures are highly indicative but not yet conclusive. | Our present knowledge of calcium or hydrogen ions as transmitters in the vertebrate rod outer segments. Difficulties in testing the possible role of calcium as a Transmitter in the R.O.S. are discussed. A comparison is made with the Sarcoplasmic Reticulum system where calcium flux are easily measured. The latest result... | [
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PMID:15672 | Properties of intracellular ribonuclease utilized for RNA reduction in disintegrated cells of Saccharomyces cerevisiae. | The properties of intracellular RNase in disintegrated cell suspensions of Saccharomyces cerevisiae have been studied. The influence of salt addition and/or incubation of the suspension on the activity of RNase and on the degradation of endogenous RNA was determined. No significant change in the RNase activity in the d... | Properties of intracellular ribonuclease utilized for RNA reduction in disintegrated cells of Saccharomyces cerevisiae. The properties of intracellular RNase in disintegrated cell suspensions of Saccharomyces cerevisiae have been studied. The influence of salt addition and/or incubation of the suspension on the activit... | [
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PMID:15673 | Fermentation of glucose by Acetobacter melanogenus. | Growing cultures of Acetobacter melanogenus ATCC 9937 concerted D-glucose to 2,5-diketo-D-gluconic acid with D-gluconic acid and 5-keto-D-gluconic acid as intermediates. The 2,5-diketo-D-gluconic acid was isolated from the fermented medium by treatment with an anion exchange resin. | Fermentation of glucose by Acetobacter melanogenus. Growing cultures of Acetobacter melanogenus ATCC 9937 concerted D-glucose to 2,5-diketo-D-gluconic acid with D-gluconic acid and 5-keto-D-gluconic acid as intermediates. The 2,5-diketo-D-gluconic acid was isolated from the fermented medium by treatment with an anion e... | [
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PMID:15674 | Growth characteristics of Candida utilis on volatile substrate in a multistage tower fermentor. | The influence of increasing ethanol concentration in the feed on growth and physiological activity of the yeast Candida utlis was studied. The measurements were made at steady states of continuous culture under constant values of dilution rate, temperature, and pH in all stages of the fermentor; Synthetic ethanol was u... | Growth characteristics of Candida utilis on volatile substrate in a multistage tower fermentor. The influence of increasing ethanol concentration in the feed on growth and physiological activity of the yeast Candida utlis was studied. The measurements were made at steady states of continuous culture under constant valu... | [
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PMID:15677 | The enzymatic conversion of L-histidine to urocanic acid by whole cells of Micrococcus luteus immobilized on carbodiimide activated carboxymethylcellulose. | Whole cells of Micrococcus luteus (formerly Sarcina lutea ATCC 9341) have been covalently linked to a carboxymethylcellulose support system, with the retention of histidine ammonia-lyase activity. The dependence of the rate of urocanic acid formation on pH, temperature, and added surfactant concentration was similar fo... | The enzymatic conversion of L-histidine to urocanic acid by whole cells of Micrococcus luteus immobilized on carbodiimide activated carboxymethylcellulose. Whole cells of Micrococcus luteus (formerly Sarcina lutea ATCC 9341) have been covalently linked to a carboxymethylcellulose support system, with the retention of h... | [
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PMID:15678 | Pepsin immobilized on inorganic supports for the continuous coagulation of skim milk. | The milk-clotting enzyme pepsin was immobilized onto beads of alumina, titania, glass, stainless steel, iron oxide, and Teflon for treating skim milk in a fluidized-bed reactor. Two covalent attachment procedures using silanized supports and glutaraldehyde and two adsorption procedures were evaluated. The three best ca... | Pepsin immobilized on inorganic supports for the continuous coagulation of skim milk. The milk-clotting enzyme pepsin was immobilized onto beads of alumina, titania, glass, stainless steel, iron oxide, and Teflon for treating skim milk in a fluidized-bed reactor. Two covalent attachment procedures using silanized suppo... | [
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PMID:15680 | [Effect of abrogating hybrid resistance on the survival of radiation chimeras]. | A study was made of the effect of the hybrid resistance abrogation by means of the lymphoid cell administration on the survival of the lethally irradiated mice protected by the transplantation of the semiallogeneic bone marrow. Injection to the C57BLxCBA recipients of the C57BL lymphoid cells one day before the irradia... | [Effect of abrogating hybrid resistance on the survival of radiation chimeras]. A study was made of the effect of the hybrid resistance abrogation by means of the lymphoid cell administration on the survival of the lethally irradiated mice protected by the transplantation of the semiallogeneic bone marrow. Injection to... | [
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PMID:15681 | [Effect of 3-acetylpyridine on the functional activity of the adrenal cortex]. | A reduction of blood corticosteroid content was observed in rats blood after the administration of 3-acetylpyridine. The rats given ACTH after 3-acetylpyridine showed a lesser elevation of corticosteroids in the blood and adrenal gland tissue than the intact animals; 3-acetylpyridine diminished the activity of dehydrog... | [Effect of 3-acetylpyridine on the functional activity of the adrenal cortex]. A reduction of blood corticosteroid content was observed in rats blood after the administration of 3-acetylpyridine. The rats given ACTH after 3-acetylpyridine showed a lesser elevation of corticosteroids in the blood and adrenal gland tissu... | [
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PMID:15682 | [Participation of non-specific rat liver microsome oxidases in destruction of Nl-furanidylpyrimidines]. | N1-(3'-Butyrolactono)-5-fluorouracil, N1-(2'-furanidyl) 5-trifluoromethyluracil, N1-(2'-furanidyl)-5-fluoracil are split in the rat organism with the formation of free 5-fluorouracil. The destruction of the C--N bonds in the molecule of the N1-(2'-furanidyl)-5-fluoracil takes place in the liver microsomes. This process... | [Participation of non-specific rat liver microsome oxidases in destruction of Nl-furanidylpyrimidines]. N1-(3'-Butyrolactono)-5-fluorouracil, N1-(2'-furanidyl) 5-trifluoromethyluracil, N1-(2'-furanidyl)-5-fluoracil are split in the rat organism with the formation of free 5-fluorouracil. The destruction of the C--N bond... | [
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PMID:15684 | [Immunocompetent lymphoi- cells from pregnant mice studied in the graft-versus-host reaction]. | The capacity of lymphoid cells taken from C57BL/6 mice gravid from the CBA males (the second trimester) to induce the graft-versus-host reaction in the hybrids (CBA X C57B/6) F1 was reduced as compared with the cells of the virgin donors and syngeneic gravid mice. This was expressed by the prolonged survival of the exp... | [Immunocompetent lymphoi- cells from pregnant mice studied in the graft-versus-host reaction]. The capacity of lymphoid cells taken from C57BL/6 mice gravid from the CBA males (the second trimester) to induce the graft-versus-host reaction in the hybrids (CBA X C57B/6) F1 was reduced as compared with the cells of the v... | [
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PMID:15685 | [Development of the graft versus host reaction and its influence on pregnancy in mice following heparin administration]. | The influence of heparin on the graft-versus-host reaction (GVHR) and the peculiarities attending the development of pregnancy in female animals which survived after the GVHR were studied. Preliminary administration of heparin to the recipients prevented their death or increased their life span. An intensification of t... | [Development of the graft versus host reaction and its influence on pregnancy in mice following heparin administration]. The influence of heparin on the graft-versus-host reaction (GVHR) and the peculiarities attending the development of pregnancy in female animals which survived after the GVHR were studied. Preliminar... | [
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PMID:15686 | [Quantitative changes in gastric juice proteases in dogs during ulcer formation in the stomach]. | Disc-electrophoretic investigation of proteases of the gastric juice of dogs under normal conditions and in experimental atophan ulcer of the stomach demonstrated that in fasting dogs ulceration was accompanied by marked quantitative changes in the protease spectrum. Fraction No. 6 showed a significant elevation agains... | [Quantitative changes in gastric juice proteases in dogs during ulcer formation in the stomach]. Disc-electrophoretic investigation of proteases of the gastric juice of dogs under normal conditions and in experimental atophan ulcer of the stomach demonstrated that in fasting dogs ulceration was accompanied by marked qu... | [
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PMID:15687 | [Adrenergic component in the hepatotropic, carcinogenic effect of diethylnitrosamine]. | The effect of norepinephine, an adrenomietic drug, and of pyrroxane, its antagonist, on diethylnitrosoamine (DENA) hepatocarcinogenesis was studied in albino rats. Norepinephrine was found to stimulate carcinogenesis, whereas pyrroxane--to inhibit this process; the latter drug decreased the incidence of multicentric tu... | [Adrenergic component in the hepatotropic, carcinogenic effect of diethylnitrosamine]. The effect of norepinephine, an adrenomietic drug, and of pyrroxane, its antagonist, on diethylnitrosoamine (DENA) hepatocarcinogenesis was studied in albino rats. Norepinephrine was found to stimulate carcinogenesis, whereas pyrroxa... | [
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PMID:15688 | Current status of bone marrow transplantation for aplastic anemia and acute leukemia. | Clinical results of marrow transplantation in the treatment of aplastic anemia and acute leukemia are reviewed. The principal problem areas in this field at this time are discussed. | Current status of bone marrow transplantation for aplastic anemia and acute leukemia. Clinical results of marrow transplantation in the treatment of aplastic anemia and acute leukemia are reviewed. The principal problem areas in this field at this time are discussed. | [
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PMID:15689 | Thrombin-induced vasodilation in the hindlimb (dog). | The objective of this study is to test the hypothesis that the vasodilation produced by intra-arterial injection of thrombin to the hindlimb of a dog may be caused by the secondary release or production of some vasodilating substance. The vasodilator response to thrombin was compared with the vasodilator response to ac... | Thrombin-induced vasodilation in the hindlimb (dog). The objective of this study is to test the hypothesis that the vasodilation produced by intra-arterial injection of thrombin to the hindlimb of a dog may be caused by the secondary release or production of some vasodilating substance. The vasodilator response to thro... | [
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PMID:15691 | Anatomico-physiological considerations in exploration of the fourth ventricle. | The advancement of surgical techniques has enabled the neurosurgeon to undertake a continually more aggressive approach toward lesions within the fourth ventricle. Laboratory and clinical observations have enabled us to conclude that (1) exploration of the fourth ventricle is feasible without anatomical disruption of t... | Anatomico-physiological considerations in exploration of the fourth ventricle. The advancement of surgical techniques has enabled the neurosurgeon to undertake a continually more aggressive approach toward lesions within the fourth ventricle. Laboratory and clinical observations have enabled us to conclude that (1) exp... | [
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PMID:15693 | Uterine contractility. | Many factors appear to control uterine activity in the human, either by direct action or by modulating the effects of other agents. There is no evidence to conclude that any one substance is the pre-eminent controller of physiological activity. The final common mediator of contraction evoked by stimulants is calcium an... | Uterine contractility. Many factors appear to control uterine activity in the human, either by direct action or by modulating the effects of other agents. There is no evidence to conclude that any one substance is the pre-eminent controller of physiological activity. The final common mediator of contraction evoked by s... | [
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PMID:15696 | Characterization of (+/-)-methadone uptake by rat lung. | 1. By use of a sensitive and specific fluorescence assay procedure it was shown that after subcutaneous administration to rats, (+/-)-methadone was concentrated in the lung. Lung to serum ratios ranging from 25 to 60 were obtained indicating that the rat lung tissue was capable of extracting (+/-)-methadone against a c... | Characterization of (+/-)-methadone uptake by rat lung. 1. By use of a sensitive and specific fluorescence assay procedure it was shown that after subcutaneous administration to rats, (+/-)-methadone was concentrated in the lung. Lung to serum ratios ranging from 25 to 60 were obtained indicating that the rat lung tiss... | [
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PMID:15697 | The pharmacology of adrenergic neuronal responses in the cerebral cortex: evidence for excitatory alpha- and inhibitory beta-receptors. | 1. The technique of microelectrophoresis was used to compare the actions of a range of adrenoceptor agonists on single cortical neurones in the rat anaesthetized with halothane. 2. Phenylephrine and methoxamine were exclusively excitatory, whereas salbutamol was entirely depressant. Noradrenaline and isoprenaline could... | The pharmacology of adrenergic neuronal responses in the cerebral cortex: evidence for excitatory alpha- and inhibitory beta-receptors. 1. The technique of microelectrophoresis was used to compare the actions of a range of adrenoceptor agonists on single cortical neurones in the rat anaesthetized with halothane. 2. Phe... | [
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PMID:15698 | The effects of labetalol (AH 5158) on adrenergic transmission in the cat spleen. | 1. The competitive alpha- and beta-adrenoceptor blocking agent labetalol, in concentrations up to 10(-4) M, produced dose-dependent increases in transmitter overflow from the isolated blood perfused spleen of the cat following nerve stimulation at 10 and 30 Hz. 2. At concentrations above 10(-4) M labetol produced a pro... | The effects of labetalol (AH 5158) on adrenergic transmission in the cat spleen. 1. The competitive alpha- and beta-adrenoceptor blocking agent labetalol, in concentrations up to 10(-4) M, produced dose-dependent increases in transmitter overflow from the isolated blood perfused spleen of the cat following nerve stimul... | [
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PMID:15699 | Drug prescription in Iceland. | Two ad hoc surveys on drugs prescribed in Reykjavik during November 1972 and November 1974 were made. After the first survey a publicity campaign was launched and doctors were encouraged to change their prescribing habits; only minor changes in docotors' prescribing habits were noticed, although it is realised that thi... | Drug prescription in Iceland. Two ad hoc surveys on drugs prescribed in Reykjavik during November 1972 and November 1974 were made. After the first survey a publicity campaign was launched and doctors were encouraged to change their prescribing habits; only minor changes in docotors' prescribing habits were noticed, al... | [
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PMID:15707 | Glutamine synthetase. IX. Purification and characterization of the enzyme from sheep spleen. | Glutamine synthetase (L-glutamate: ammonia ligase (ADP-forming), EC 6.3.1.2) has been purified about 550-fold from sheep spleen. The subunit weight of the enzyme is estimated to be 48 000. Sedimentation coefficient determination by density gradient centrifugation gives a value of 15.0 S. The approximate molecular weigh... | Glutamine synthetase. IX. Purification and characterization of the enzyme from sheep spleen. Glutamine synthetase (L-glutamate: ammonia ligase (ADP-forming), EC 6.3.1.2) has been purified about 550-fold from sheep spleen. The subunit weight of the enzyme is estimated to be 48 000. Sedimentation coefficient determinatio... | [
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PMID:15708 | Factors affecting inosinate synthesis and inosine triphosphate accumulation in human erythrocytes. | Measurements of rates of inosinate synthesis from radioactive hypoxanthine by human erythrocytes show a large degree of individual variation. Rates of inosinate synthesis also vary with the pH and phosphate concentration of the incubation medium. This may be due to changes in the rate of phosphoribosyl pyrophosphate sy... | Factors affecting inosinate synthesis and inosine triphosphate accumulation in human erythrocytes. Measurements of rates of inosinate synthesis from radioactive hypoxanthine by human erythrocytes show a large degree of individual variation. Rates of inosinate synthesis also vary with the pH and phosphate concentration ... | [
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PMID:15709 | Synthesis of soluble dextran-hemoglobin complexes of different molecular sizes. | Experimental conditions were defined that determined the synthesis of dextran-hemoglobin complexes through the alklation of hemoglobin by N-bromoacetylaminoethylaminodextran. Using appropriate concentrations of the two reactants, over 90% yield of dextran-hemoglobin was obtained for dextrans of average molecular weight... | Synthesis of soluble dextran-hemoglobin complexes of different molecular sizes. Experimental conditions were defined that determined the synthesis of dextran-hemoglobin complexes through the alklation of hemoglobin by N-bromoacetylaminoethylaminodextran. Using appropriate concentrations of the two reactants, over 90% y... | [
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PMID:15710 | The chemical and kinetic consequences of the modification of papain by N-bromosuccinimide. | Nonactivated papain was treated with N-bromosuccinimide at pH 4.75. The N-bromosuccinimide-modified enzyme was characterized by (1) the change in absorbance at 280 nm, (2) amino acid analysis, (3) separate chemical determinations of tryptophan and tyrosine (4) difference spectroscopy, and (5) an N-terminal residue dete... | The chemical and kinetic consequences of the modification of papain by N-bromosuccinimide. Nonactivated papain was treated with N-bromosuccinimide at pH 4.75. The N-bromosuccinimide-modified enzyme was characterized by (1) the change in absorbance at 280 nm, (2) amino acid analysis, (3) separate chemical determinations... | [
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PMID:15711 | Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells. | We have previously described methotrexate-resistant Chinese hamster ovary cells which appear to contain normal levls of a structurally altered dihydrofolate reductase (EC 1.5.1.3) (Flintoff, W.F., Davidson, S.V., and Siminovitch, L. (1976) Somatic Cell Genet.2,245-261). By selecting for increased resistance form these ... | Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells. We have previously described methotrexate-resistant Chinese hamster ovary cells which appear to contain normal levls of a structurally altered dihydrofolate reductase (EC 1.5.1.3) (... | [
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PMID:15712 | Reversibility of the ampicillin-and nitrite-induced inactivation of beta-lactamase I. | beta-Lactamase I was isolated from Bacillus cereus 569/H. Treatment with ampicillin in the presence of sodium nitrite at pH 4 or 5 resulted in the inactivation of the enzyme presumably by modification of a carboxyl group in the active site. However, this inactivation was rapidly, reversible at neutral pH and the availa... | Reversibility of the ampicillin-and nitrite-induced inactivation of beta-lactamase I. beta-Lactamase I was isolated from Bacillus cereus 569/H. Treatment with ampicillin in the presence of sodium nitrite at pH 4 or 5 resulted in the inactivation of the enzyme presumably by modification of a carboxyl group in the active... | [
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PMID:15713 | The interactions between cytochrome c and cytochrome oxidase that determine the conformation of the oxidized oxidase. | 1. Cytochrome c2+ increases the rate at which cytochrome oxidase (EC 1.9.3.1) gamma max428nm) converts to its conformational isomer (gamma max 418-423 nm) but cytochrome c3+ has little effect on the conversion rate. 2. Interactions between reduced cytochrome oxidase and cytochrome c were studied in the absence of elect... | The interactions between cytochrome c and cytochrome oxidase that determine the conformation of the oxidized oxidase. 1. Cytochrome c2+ increases the rate at which cytochrome oxidase (EC 1.9.3.1) gamma max428nm) converts to its conformational isomer (gamma max 418-423 nm) but cytochrome c3+ has little effect on the con... | [
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PMID:15714 | Mechanism of action of Zn2+ and Mg2+ on rat placenta alkaline phosphatase. II. Studies on membrane-bound phosphatase in tissue sections and in whole placenta. | Alkaline phosphatase (EC 3.1.3.1) bound to trophoblastic cells in rat placenta is activated by Mg2+ and inhibited by Zn2+ in the same way as is found with partially purified soluble alkaline phosphatase in the same tissue (PetitClerc, C., Delisle, M., Martel, M., Fecteau, C. & Brière, N. (1975) Can. J. Biochem. 53,... | Mechanism of action of Zn2+ and Mg2+ on rat placenta alkaline phosphatase. II. Studies on membrane-bound phosphatase in tissue sections and in whole placenta. Alkaline phosphatase (EC 3.1.3.1) bound to trophoblastic cells in rat placenta is activated by Mg2+ and inhibited by Zn2+ in the same way as is found with partia... | [
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PMID:15715 | The subcellular distribution of poly-A-degrading activity in mouse kidney. | Most (95%) of the poly-A-degrading activity of the mouse kidney was found in the cytoplasmic fraction and only 5% was found in the nuclear fraction; 43% of the poly-A-degrading activity of the cytoplasm was found in the mitochondria, 22% in the microsomes, and 30% in the soluble fraction. Differences in activity and sp... | The subcellular distribution of poly-A-degrading activity in mouse kidney. Most (95%) of the poly-A-degrading activity of the mouse kidney was found in the cytoplasmic fraction and only 5% was found in the nuclear fraction; 43% of the poly-A-degrading activity of the cytoplasm was found in the mitochondria, 22% in the ... | [
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PMID:15716 | The effects of light and tyrosinase during sclerotium development in Sclerotium rolfsii Sacc. | Some effects of light on morphogenesis in Sclerotium rolfsii Sacc. were studied. Physiological competence to visible light developed during the first 120 h after inoculation, with an optimum sensitivity phase between 84 and 96 h that coincided with the leading hyphae reaching the edge of the Petri dish. Although sclero... | The effects of light and tyrosinase during sclerotium development in Sclerotium rolfsii Sacc. Some effects of light on morphogenesis in Sclerotium rolfsii Sacc. were studied. Physiological competence to visible light developed during the first 120 h after inoculation, with an optimum sensitivity phase between 84 and 96... | [
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PMID:15717 | Stannous and cuprous ion oxidation by Thiobacillus ferrooxidans. | Oxidation of stannous chloride by Thiobacillus ferrooxidans was studied manometrically. At low stannous ion concentrations, initial oxidation rate was proportional to concentration. Optimum pH for oxidation was 2.3 optimum temperature was 37-40 degrees C. Spectrophotometry showed reduction of cytochromes in suspensions... | Stannous and cuprous ion oxidation by Thiobacillus ferrooxidans. Oxidation of stannous chloride by Thiobacillus ferrooxidans was studied manometrically. At low stannous ion concentrations, initial oxidation rate was proportional to concentration. Optimum pH for oxidation was 2.3 optimum temperature was 37-40 degrees C.... | [
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PMID:15719 | Prolactin binding in ovariectomy-responsive and ovariectomy-nonresponsive rat mammary carcinoma. | Growth of the transplantable mammary tumor, MTW9, in W/Fu rats is greatly enhanced by elevated serum prolactin concentrations. This report compares the prolactin binding to tumor membranes in two mammary tumor strains derived from MTW9. Maximum binding to membranes of both tumors occurred at pH 7.6 after incubation for... | Prolactin binding in ovariectomy-responsive and ovariectomy-nonresponsive rat mammary carcinoma. Growth of the transplantable mammary tumor, MTW9, in W/Fu rats is greatly enhanced by elevated serum prolactin concentrations. This report compares the prolactin binding to tumor membranes in two mammary tumor strains deriv... | [
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PMID:15720 | Transglutaminase activity in normal and transformed cells. | Transglutaminase activity was determined in normal and transformed paired cell systems. Reduced enzyme activity was found in virus-transformed human and hamster cells and in chemically transformed mouse cells relative to normal counterparts. Most of the enzyme activity was localized in the particulate fraction sediment... | Transglutaminase activity in normal and transformed cells. Transglutaminase activity was determined in normal and transformed paired cell systems. Reduced enzyme activity was found in virus-transformed human and hamster cells and in chemically transformed mouse cells relative to normal counterparts. Most of the enzyme ... | [
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PMID:15721 | Interactions between "fever" proteins and normal serum proteins in febrile cancer patients. | When analyzed by cationic discontinuous electrophoresis in urea-containing polyacrylamide gels, plasma or serum from febrile individuals contains trace quanitites of five protein bands that are not recognizable in the blood of normal individuals. These proteins appear and disappear in parallel in sequential samples. Ce... | Interactions between "fever" proteins and normal serum proteins in febrile cancer patients. When analyzed by cationic discontinuous electrophoresis in urea-containing polyacrylamide gels, plasma or serum from febrile individuals contains trace quanitites of five protein bands that are not recognizable in the blood of n... | [
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PMID:15722 | Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore. | Cultured human neuroblastoma cell lines were assayed for biochemical characteristics of neuonal function. Cell lines studied included LA-N-1, LA-N-2, IMR-32, SK-N-SH, and SK-N-MC. Veratridine-dependent uptake of 22Na+ implied the presence of the action potential Na+ ionophore in LA-N-1, LA-N-2, IMR-32, and SK-N-SH. The... | Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore. Cultured human neuroblastoma cell lines were assayed for biochemical characteristics of neuonal function. Cell lines studied included LA-N-1, LA-N-2, IMR-32, SK-N-SH, and SK-N-MC. Veratridine-dependent uptake o... | [
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PMID:15723 | Effects of graft-versus-host reaction on inhibition of tumor growth in vivo and on tumor cytotoxicity in vitro. | In DA X Wistar F1 rats, growth of 10(4) Wistar-specific Sp 1 carcinoma cells s.c. was commonly prevented by a mild subclinical graft=versus-host reaction produced by injecting 50 X 10(6) Wistar spleen cells i.p. either concurrently with the tumor or 7 to 14 days previously, Spleen cells alone had no effect on establish... | Effects of graft-versus-host reaction on inhibition of tumor growth in vivo and on tumor cytotoxicity in vitro. In DA X Wistar F1 rats, growth of 10(4) Wistar-specific Sp 1 carcinoma cells s.c. was commonly prevented by a mild subclinical graft=versus-host reaction produced by injecting 50 X 10(6) Wistar spleen cells i... | [
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PMID:15724 | Reactions of cellulose isothiocyanates with thiol and amino compounds. | A cellulose isothiocyanate has been prepared by treatment of cellulose with 2,4-di-isocyanatotoluene followed by hydrolysis and reaction of the resulting amine with thiophosgene. The cellulose isothiocyanate was characterized by its binding capacity with respect to [14C]-glycine, [131 I]-human serum albumin, and 2-merc... | Reactions of cellulose isothiocyanates with thiol and amino compounds. A cellulose isothiocyanate has been prepared by treatment of cellulose with 2,4-di-isocyanatotoluene followed by hydrolysis and reaction of the resulting amine with thiophosgene. The cellulose isothiocyanate was characterized by its binding capacity... | [
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PMID:15727 | Proliferation of erythroid and granulocyte progenitors in the spleen as a function of stem cell dose. | A study of the kinetics of cellular proliferation, in the morphologically unrecongizable haemopoietic progenitor cell compartment, as a function of injected CFU-S dose has been carried out in the spleens of lethally X-irradiated mice using 3H-TdR labelling. Amplification in this proliferating cell compartment was obser... | Proliferation of erythroid and granulocyte progenitors in the spleen as a function of stem cell dose. A study of the kinetics of cellular proliferation, in the morphologically unrecongizable haemopoietic progenitor cell compartment, as a function of injected CFU-S dose has been carried out in the spleens of lethally X-... | [
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PMID:15728 | The form and function of cnidarian spirocysts. 3. Ultrastructure of the thread and the function of spirocysts. | Unlike most nematocysts, undischarged spirocyst threads bear hollow tubules rather than spines. The undischarged tubules are interconnected in hexagonal arrays and appear to be arranged in bundles along the length of the thread. Although the wall of the thread is folded in length and width, the tubules are not. Upon di... | The form and function of cnidarian spirocysts. 3. Ultrastructure of the thread and the function of spirocysts. Unlike most nematocysts, undischarged spirocyst threads bear hollow tubules rather than spines. The undischarged tubules are interconnected in hexagonal arrays and appear to be arranged in bundles along the le... | [
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PMID:15730 | Importance of glycerol and fatty acid residues on the ionic properties of phosphatidylglycerols at the air-water interface. | Ionic properties of didodecanoylphosphatidylglycerol (C12PG), didodecanolyphosphatidyl-l'-propanol (C12PP), di-(12-methyl, 13-methyl)-pentadecanoylphosphatidylglycerols (C15PG) and dihexadecanoylphosphatidylglycerol (C16PG) have been studied at the air-water interface using titration experiments at constant ionic stren... | Importance of glycerol and fatty acid residues on the ionic properties of phosphatidylglycerols at the air-water interface. Ionic properties of didodecanoylphosphatidylglycerol (C12PG), didodecanolyphosphatidyl-l'-propanol (C12PP), di-(12-methyl, 13-methyl)-pentadecanoylphosphatidylglycerols (C15PG) and dihexadecanoylp... | [
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PMID:15731 | [Increase in the oxygen available to the cerebral cortex after the administration of carbonic anhydrase inhibitors]. | Oxygen tension (pO2) in cerebral cortex was measured by polarographic method in unanesthetized rabbits. Intravenous administration (25 mg/kg) of carbonic anhydrase inhibitors (acetazolamide, methazolamide, dichlorphenamide, sulthiame) induced an early important rise of cortical p O2, which is not dependent on increase ... | [Increase in the oxygen available to the cerebral cortex after the administration of carbonic anhydrase inhibitors]. Oxygen tension (pO2) in cerebral cortex was measured by polarographic method in unanesthetized rabbits. Intravenous administration (25 mg/kg) of carbonic anhydrase inhibitors (acetazolamide, methazolamid... | [
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PMID:15733 | An extrarenal source of "renin-like" activity in anephric man. | To examine extrarenal sources of "renin-like" activity plasma was obtained from 19 anephric males. Plasma renin activity (PRA), concentration (PRC) (obtained after addition of exogenous renin substrate) and total renin concentration (TRC) (obtained after acid-activation of plasma and subsequent incubation with exogenou... | An extrarenal source of "renin-like" activity in anephric man. To examine extrarenal sources of "renin-like" activity plasma was obtained from 19 anephric males. Plasma renin activity (PRA), concentration (PRC) (obtained after addition of exogenous renin substrate) and total renin concentration (TRC) (obtained after ac... | [
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PMID:15736 | An inactive renin in human plasma. | Normal human plasma contains an active form of renin that is activated by acidification to pH 3.0 and comprises 56% of the total renin. In our study, inactive renin was also present in plasma from five anephric persons, and the proportion of active to inactive renin in these subjects was similar to normal. Plasma from ... | An inactive renin in human plasma. Normal human plasma contains an active form of renin that is activated by acidification to pH 3.0 and comprises 56% of the total renin. In our study, inactive renin was also present in plasma from five anephric persons, and the proportion of active to inactive renin in these subjects ... | [
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PMID:15737 | Effect of beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release from rat kidney slices. | Mechanisms by which beta-blocking agents decrease blood pressure and suppress renin release are incompletely understood. We previously demonstrated that renin release by kidney slices may be increased by beta-adrenergic agonists, and the present communication contains our results on the effects of 15 beta-blocking agen... | Effect of beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release from rat kidney slices. Mechanisms by which beta-blocking agents decrease blood pressure and suppress renin release are incompletely understood. We previously demonstrated that renin release by kidney slices may be increased by ... | [
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PMID:15738 | alpha-Adrenergic reduction of cyclic adenosine monophosphate concentrations in rat myocardium. | We determined the effect of alpha-adrenergic receptor stimulation on cyclic adenosine monophosphate (cyclic AMP) concentrations in isolated myocytes derived from adult rat hearts and in isolated perfused rat hearts. Activation of alpha-adrenergic receptors with either phenylephrine (10(-8) M to 10(-6) M) or epinephrine... | alpha-Adrenergic reduction of cyclic adenosine monophosphate concentrations in rat myocardium. We determined the effect of alpha-adrenergic receptor stimulation on cyclic adenosine monophosphate (cyclic AMP) concentrations in isolated myocytes derived from adult rat hearts and in isolated perfused rat hearts. Activatio... | [
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PMID:15739 | Detection of errors in methylmalonyl-CoA metabolism by using amniotic fluid. | We report a method for rapid prenatal detection of methylmalonic acidemia, consisting of measuring methylmalonly-CoA mutase (EC 5.4.99.2) activity in non-cultured amniotic cells and measuring the concentration of methylmalonate in the amniotic fluid. Immediate stabilization of the mutase activity in the non-cultured am... | Detection of errors in methylmalonyl-CoA metabolism by using amniotic fluid. We report a method for rapid prenatal detection of methylmalonic acidemia, consisting of measuring methylmalonly-CoA mutase (EC 5.4.99.2) activity in non-cultured amniotic cells and measuring the concentration of methylmalonate in the amniotic... | [
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PMID:15740 | The effects of ethanol (0.75 g/kg body weight) on the activities of selected enzymes in sera of healthy young adults: 1. Intermediate-term effects. | We report the intermediate-term effects of three consecutive evenings of moderate ethanol ingestion (0.75 g/kg body weight each evening) on activity values for alkaline phosphatase, gamma-glutamyltransferase, creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase in sera of nin... | The effects of ethanol (0.75 g/kg body weight) on the activities of selected enzymes in sera of healthy young adults: 1. Intermediate-term effects. We report the intermediate-term effects of three consecutive evenings of moderate ethanol ingestion (0.75 g/kg body weight each evening) on activity values for alkaline pho... | [
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PMID:15741 | New substrate for fluorometric determination of gamma-glutamyltransferase activity in serum. | We describe the preparation of a new substrate, N-gamma-L-glutamyl-5-aminoisophthalic acid dimethyl ester hydro-chloride, for the fluorometric determination of gamma-glutamyltransferase activity in serum by the "front-surface" technique. Details of the resulting method are provided. The final reaction mixture contains ... | New substrate for fluorometric determination of gamma-glutamyltransferase activity in serum. We describe the preparation of a new substrate, N-gamma-L-glutamyl-5-aminoisophthalic acid dimethyl ester hydro-chloride, for the fluorometric determination of gamma-glutamyltransferase activity in serum by the "front-surface" ... | [
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PMID:15742 | Gamma-glutamyltransferase activity in plasma: statistical distributions, individual variations, and reference intervals. | Measurement of gamma-glutamyltransferase activity in plasma provides a useful index to liver function. Using as our study population those persons coming to the Center for Preventive Medicine, we described and measured the significance and importance of physiological and environmental variations. We established a class... | Gamma-glutamyltransferase activity in plasma: statistical distributions, individual variations, and reference intervals. Measurement of gamma-glutamyltransferase activity in plasma provides a useful index to liver function. Using as our study population those persons coming to the Center for Preventive Medicine, we des... | [
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PMID:15743 | Vitamin B12 radioassay with oyster toadfish (Opsanus tau) serum as binder. | We describe a vitamin B12 radioassay in which oyster toadfish (Opsanus tau) serum is used as the binding protein. The serum is quite stable and has a high capacity and high binding affinity (K greater than 10(12) liter/mol) for vitamin B12. The binding is not significantly affected by temperature, the presence of denat... | Vitamin B12 radioassay with oyster toadfish (Opsanus tau) serum as binder. We describe a vitamin B12 radioassay in which oyster toadfish (Opsanus tau) serum is used as the binding protein. The serum is quite stable and has a high capacity and high binding affinity (K greater than 10(12) liter/mol) for vitamin B12. The ... | [
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PMID:15744 | Canaline carbamoyltransferase in human liver as part of a metabolic cycle in which guanidino compounds are formed. | This and previous papers examine the reasons for the relationship between the concentrations of guanidino-succinate and guanidinoacetate in human urine. With the demonstration here that extracts of human liver-tissue can mediate ureidohomoserine formation from canaline [(2-amino-4-aminooxy)-butyric acid] and carbamoyl ... | Canaline carbamoyltransferase in human liver as part of a metabolic cycle in which guanidino compounds are formed. This and previous papers examine the reasons for the relationship between the concentrations of guanidino-succinate and guanidinoacetate in human urine. With the demonstration here that extracts of human l... | [
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PMID:15745 | Diurnal variations of urinary enzyme excretion. | Variations in the urinary excretion of arylsulphatase A, beta-galactosidase, alpha-glucosidase and beta-glucuronidase throughout a 24-h period were studied in 8 healthy subjects. Urine was collected at 3-h intervals and enzyme activities were assayed after gelfiltration of the urine specimens. Significant intra-individ... | Diurnal variations of urinary enzyme excretion. Variations in the urinary excretion of arylsulphatase A, beta-galactosidase, alpha-glucosidase and beta-glucuronidase throughout a 24-h period were studied in 8 healthy subjects. Urine was collected at 3-h intervals and enzyme activities were assayed after gelfiltration o... | [
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PMID:15747 | Properties of amylase-linked immunoglobulins. | In this report, the properties of eight cases of amylase-linked immunoglobulins were gel filtration using Sephadex G-200 superfine. The class of heavy chain of amylase-linked immunoglobulins was proved to be gamma in four cases and alpha in three cases by immunoelectrophoresis followed by amylase activity staining. In ... | Properties of amylase-linked immunoglobulins. In this report, the properties of eight cases of amylase-linked immunoglobulins were gel filtration using Sephadex G-200 superfine. The class of heavy chain of amylase-linked immunoglobulins was proved to be gamma in four cases and alpha in three cases by immunoelectrophore... | [
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PMID:15748 | Determination of total carbon dioxide in serum and plasma using a carbonate ion-selective membrane electrode. | A new manual method for the determination of carbon dioxide content in serum and plasma, based on the potentiometric measurement of carbonate, is proposed and evaluated. The new method offers good precision and accuracy in the physiological concentration range as shown by detailed studies on synthetic samples, referenc... | Determination of total carbon dioxide in serum and plasma using a carbonate ion-selective membrane electrode. A new manual method for the determination of carbon dioxide content in serum and plasma, based on the potentiometric measurement of carbonate, is proposed and evaluated. The new method offers good precision and... | [
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PMID:15751 | Clotting in dialyzers due to low pH of dialysis fluid. | During November and December 1975 frequent clotting occurred in the extracorporeal circuits of different dialyzers used in our unit. After installation of new automatically regenerating ion exchange resin columns,, the pH of deionized water ranged from 4.2 to 8.4 during 24 hr periods. Dialysate pH ranged between 5.3 an... | Clotting in dialyzers due to low pH of dialysis fluid. During November and December 1975 frequent clotting occurred in the extracorporeal circuits of different dialyzers used in our unit. After installation of new automatically regenerating ion exchange resin columns,, the pH of deionized water ranged from 4.2 to 8.4 d... | [
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PMID:15753 | Influence of intrinsic sympathomimetic activity and cardioselectivity on beta adrenoceptor blockade. | Dose-response curves for propranolol and oxprenolol were studied in healthy volunteers, with a standardized excercise test and percentage reduction in excercise heart rate (EHR) as the index of drug effect. The dose-response curves obtained were compared with similar curves previously reported for sotalol, practolol, a... | Influence of intrinsic sympathomimetic activity and cardioselectivity on beta adrenoceptor blockade. Dose-response curves for propranolol and oxprenolol were studied in healthy volunteers, with a standardized excercise test and percentage reduction in excercise heart rate (EHR) as the index of drug effect. The dose-res... | [
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PMID:15754 | The physiologic treatment of nasal obstruction. | Although criticisms of the submucous resection of the nasal septum and turbinectomy have been given, this is not to discredit these procedures when they are truly indicated. Certainly there are anatomic deformities causing nasal obstruction wherein a submucous resection of the septum or a submucous resection of the ant... | The physiologic treatment of nasal obstruction. Although criticisms of the submucous resection of the nasal septum and turbinectomy have been given, this is not to discredit these procedures when they are truly indicated. Certainly there are anatomic deformities causing nasal obstruction wherein a submucous resection o... | [
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PMID:15755 | Valsalva vasoconstrictor reflex in human hypertension in after beta-adrenoreceptor blockade in conscious rabbits. | 1. A Valsalva-like manoeuvre was used to elicit graded rises in total peripheral resistance (TPR) in conscious rabbits. The rises were reflex and mediated through sympathetic constrictors. Propranolol infused at different rates reaching plasma concentrations up to 240 (SEM 33) ng/ml had no effect on this reflex but red... | Valsalva vasoconstrictor reflex in human hypertension in after beta-adrenoreceptor blockade in conscious rabbits. 1. A Valsalva-like manoeuvre was used to elicit graded rises in total peripheral resistance (TPR) in conscious rabbits. The rises were reflex and mediated through sympathetic constrictors. Propranolol infus... | [
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PMID:15756 | Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. | 1. Activity of peripheral and central catecholaminergic neurons was studied in spontaneously hypertensive rats (SHR) and deoxycorticosterone (DOCA)-salt hypertensive rats. 2. In young SHR (4 weeks) the plasma values of bpth noradrenaline and dopamine-beta-hydroxylase activity were increased compared with those of normo... | Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. 1. Activity of peripheral and central catecholaminergic neurons was studied in spontaneously hypertensive rats (SHR) and deoxycorticosterone (DOCA)-salt hypertensive rats. 2. In young SHR (4 weeks) the plasma values of bp... | [
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PMID:15757 | The role of alpha- and beta-presynaptic receptors in the regulation of noradrenaline release elicited by nerve stimulation. | 1. The presynaptic mechanisms appear to be involved in the regulation of noradrenaline release during nerve stimulation. The first one. mediated by beta-adrenoceptors, operates at low frequencies of nerve stimulation, leading to an increase in transmitter release. The second one, mediated through alpha-adrenoceptors, i... | The role of alpha- and beta-presynaptic receptors in the regulation of noradrenaline release elicited by nerve stimulation. 1. The presynaptic mechanisms appear to be involved in the regulation of noradrenaline release during nerve stimulation. The first one. mediated by beta-adrenoceptors, operates at low frequencies ... | [
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PMID:15758 | Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. | 1. Beta-Recptor-blocking drugs are rapidly and completely absorbed after oral administration. Systemic availability is nevertheless incomplete for propranolol, alprenolol and oxprenolol, owing to "first-pass' extraction by the liver. 2. Plasma half-life is between 2 and 4 h, except for sotalol (10-12 h). Plasma elimina... | Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. 1. Beta-Recptor-blocking drugs are rapidly and completely absorbed after oral administration. Systemic availability is nevertheless incomplete for propranolol, alprenolol and oxprenolol, owing to "first-pass' extraction by ... | [
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PMID:15759 | Haemodynamic long-term effects of beta-receptor-blocking agents in hypertension: a comparison between alprenolol, atenolol, metoprolol and timolol. | 1. Oxygen consumption and central haemodynamics were recorded at rest and during exercise in fifty-one men with essential hypertension (W.H.O. stage I) and repeated after 1 year on a single drug: alprenolol (n equals 10), atenolol (13) metoprolol (12) and timolol (16). 2. Mean arterial pressure was significantly reduce... | Haemodynamic long-term effects of beta-receptor-blocking agents in hypertension: a comparison between alprenolol, atenolol, metoprolol and timolol. 1. Oxygen consumption and central haemodynamics were recorded at rest and during exercise in fifty-one men with essential hypertension (W.H.O. stage I) and repeated after 1... | [
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