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PMID:16655 | Possible regulation of thiamine diphosphatase activity in rat brain microsomes by lipids. | The effects of various treatments, which affect membrane structure, on microsomal thiamine diphosphatase and thiamine triphosphatase activities of rat brain, were examined. The treatment of micorosomes at alkaline pH caused a 2-fold activation of the thiamine diphosphatase, this being related to a change in membrane st... | Possible regulation of thiamine diphosphatase activity in rat brain microsomes by lipids. The effects of various treatments, which affect membrane structure, on microsomal thiamine diphosphatase and thiamine triphosphatase activities of rat brain, were examined. The treatment of micorosomes at alkaline pH caused a 2-fo... | [
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PMID:16656 | Inhibition of alkaline phosphatase by sialic acid. | The interaction of human organ alkaline phosphatases (orthophosphoric-monoester phosphohydrolases (alkaline optimum), EC 3.1.3.1) with sugars was studied. Hexosamines, N-acetylneuraminic acid (NANA or sialic acid), N-acetylmuramic acid and N-acetylglycolylneuraminic acid inhibited human organ alkaline phosphatase activ... | Inhibition of alkaline phosphatase by sialic acid. The interaction of human organ alkaline phosphatases (orthophosphoric-monoester phosphohydrolases (alkaline optimum), EC 3.1.3.1) with sugars was studied. Hexosamines, N-acetylneuraminic acid (NANA or sialic acid), N-acetylmuramic acid and N-acetylglycolylneuraminic ac... | [
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PMID:16657 | Some properties of human liver acid alpha-glucosidase. | 1. Albumin activates human liver acid alpha-glucosidase (alpha-D-glucoside hydrolase, EC 3.2.1.20). From the Arrhenius plot, pH-dependence and Lineweaver-Burk plots it can be concluded that this activation is not only due to stabilisation of the enzyme, but also influences the enzymatic activity. It is proposed that fo... | Some properties of human liver acid alpha-glucosidase. 1. Albumin activates human liver acid alpha-glucosidase (alpha-D-glucoside hydrolase, EC 3.2.1.20). From the Arrhenius plot, pH-dependence and Lineweaver-Burk plots it can be concluded that this activation is not only due to stabilisation of the enzyme, but also in... | [
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PMID:16658 | Lysosomal phospholipase A activities of rat ovarian tissue. | 1.1. Lysosome-enriched fractions were prepared by differential centrifugation of homogenates of luteinized rats ovaries. Acid phospholipase A activities were characterized with [U-14C]diacyl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-[9,10-3H]- or [1-14C]oleoyl-sn-glycero-3-phosphocholine as substrates. Acid phospho... | Lysosomal phospholipase A activities of rat ovarian tissue. 1.1. Lysosome-enriched fractions were prepared by differential centrifugation of homogenates of luteinized rats ovaries. Acid phospholipase A activities were characterized with [U-14C]diacyl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-[9,10-3H]- or [1-14C]ol... | [
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PMID:16659 | Phospholipase A in pulmonary secretions of patients with alveolar proteinosis. | This report presents evidence for the presence of phospholipase A2 (EC 3.1.1.4) activity in the insoluble pulmonary secretions of patients with alveolar proteinosis. The enzyme activity has a pH optimum between 7.5 and 8.5 and is stimulated by deoxycholate and Ca2+. | Phospholipase A in pulmonary secretions of patients with alveolar proteinosis. This report presents evidence for the presence of phospholipase A2 (EC 3.1.1.4) activity in the insoluble pulmonary secretions of patients with alveolar proteinosis. The enzyme activity has a pH optimum between 7.5 and 8.5 and is stimulated ... | [
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PMID:16660 | Specific phospholipid requirement for activity of the purified respiratory chain NADH dehydrogenase of Escherichia coli. | The highly purified respiratory chain NADH dehydrogenase (EC 1.6.99.3) of Escherichia coli is inactive in the absence of detergent or phospholipid. Triton X-100 is the detergent that gives optimal activity, but the Triton X-100-activated enzyme is stimulated an additional 2-fold by E. coli phospholipids. Phosphatidylgl... | Specific phospholipid requirement for activity of the purified respiratory chain NADH dehydrogenase of Escherichia coli. The highly purified respiratory chain NADH dehydrogenase (EC 1.6.99.3) of Escherichia coli is inactive in the absence of detergent or phospholipid. Triton X-100 is the detergent that gives optimal ac... | [
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PMID:16661 | Effect of hydrophobic probes on the higher structure of D-amino acid oxidase. | 1. The holoenzyme of D-amino acid oxidase [D-amino acid: O2 oxidoreductase (deaminating), EC 1.4.3.3] was found to combine with 1-anilinonaphthalene-8-sulfonate without liberation of its coenzyme, FAD. No energy transfer interaction was found to occur between the bound dye and FAD of the holoenzyme. On the other hand, ... | Effect of hydrophobic probes on the higher structure of D-amino acid oxidase. 1. The holoenzyme of D-amino acid oxidase [D-amino acid: O2 oxidoreductase (deaminating), EC 1.4.3.3] was found to combine with 1-anilinonaphthalene-8-sulfonate without liberation of its coenzyme, FAD. No energy transfer interaction was found... | [
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PMID:16662 | The interaction of histone H3 with histone H4 and with other histones studied by 19F nuclear magnetic resonance. | The behaviour, upon variations in ionic strength, pH and temperature of 19F nuclear nuclear magnetic resonance signals of the trifluoroacetonylated derivative of histone H3 is compared with those of the H3-H4 complex and of the Hv fraction (an equimolar mixture of H2A, H2B, H3 and h4). The line width of the 19F-labelle... | The interaction of histone H3 with histone H4 and with other histones studied by 19F nuclear magnetic resonance. The behaviour, upon variations in ionic strength, pH and temperature of 19F nuclear nuclear magnetic resonance signals of the trifluoroacetonylated derivative of histone H3 is compared with those of the H3-H... | [
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PMID:16664 | The denaturation of beta-lactoglobulin-A at pH 2. | The denaturation of beta-lactoglobulin-A by heat and guanidine hydrochloride at pH 2 has been investigated. The effect of ethylene glycol on the thermal denaturation at this pH has also been studied. The conditions of the experiments have been chosen so as to eliminate complications arising out of disulfide interchange... | The denaturation of beta-lactoglobulin-A at pH 2. The denaturation of beta-lactoglobulin-A by heat and guanidine hydrochloride at pH 2 has been investigated. The effect of ethylene glycol on the thermal denaturation at this pH has also been studied. The conditions of the experiments have been chosen so as to eliminate ... | [
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PMID:16667 | [Influence of pH on the steady state kinetics of electron transfer through the cytochrome chain of submitochondrial particles. Kinetic model for regulating the activity of carriers by the local concentration of hydrogen ions in the membrane]. | The kinetic parameters of the submitochondrial particles cytochrome chain obtained from steady-state kinetics were studied for pH dependence. The life-times of the activated states (tau) for cytochrome pairs b leads to c1 and a leads to a3 are shown to bear dissimilar dependence on pH of the medium, while for cytochrom... | [Influence of pH on the steady state kinetics of electron transfer through the cytochrome chain of submitochondrial particles. Kinetic model for regulating the activity of carriers by the local concentration of hydrogen ions in the membrane]. The kinetic parameters of the submitochondrial particles cytochrome chain obt... | [
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PMID:16668 | [Properties of alpha-chymotrypsin and cis-cinnamoylchymotrypsin in free, covalently bound to a carrier and microcapsulated states]. | alpha-Chymotrypsin and its light-sensitive derivative, cis-cinnamoylchymotrypsin, free and immobilysed (by means of microcapsulation, covalent binding with sepharose 4B and p-aminobenzyl cellulose) are studied. Effect of pH on the hydrolysis rate of N-alpha-acetyl-L-tyrosine ethyl ester by different immobilized enzyme ... | [Properties of alpha-chymotrypsin and cis-cinnamoylchymotrypsin in free, covalently bound to a carrier and microcapsulated states]. alpha-Chymotrypsin and its light-sensitive derivative, cis-cinnamoylchymotrypsin, free and immobilysed (by means of microcapsulation, covalent binding with sepharose 4B and p-aminobenzyl c... | [
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PMID:16669 | [Role of low-molecular weight factors isolated from Methanobacillus kuzneceovii in the activating effect of visible light on methane formation and reduction of pyridine nucleotides]. | Four low molecular weight fluorescent factors are isolated from thermophylic methaneproducing facteria Methanobacterium kuzneceovii. These factors are: the factor 340; the factor 420 (both reduced and oxidized); and a flavine derivative, comprising together with proteins a biochemical system, which reduces pyridine nuc... | [Role of low-molecular weight factors isolated from Methanobacillus kuzneceovii in the activating effect of visible light on methane formation and reduction of pyridine nucleotides]. Four low molecular weight fluorescent factors are isolated from thermophylic methaneproducing facteria Methanobacterium kuzneceovii. Thes... | [
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PMID:16670 | The effect of birth on the maturation of hepatic cytochrome(s) P-450 mono-oxygenase and tyrosine aminotransferase activities in the guinea pig. | Mixed coat guinea pigs delivered by Cesarian section 5 days before term were compared to spontaneously delivered full-term animals with respect to the postnatal maturation of hepatic mono-oxygenase activity in vitro toward aniline and p-chloro-N-methylaniline. Tyrosine aminotransferase acitivity was studied in the same... | The effect of birth on the maturation of hepatic cytochrome(s) P-450 mono-oxygenase and tyrosine aminotransferase activities in the guinea pig. Mixed coat guinea pigs delivered by Cesarian section 5 days before term were compared to spontaneously delivered full-term animals with respect to the postnatal maturation of h... | [
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PMID:16671 | Human cytomegalovirus. A review of developments between 1970 and 1976. I. Clinical developments. | Cytomegalovirus (CMV), like other members of the herpesviruses, is widely distributed in human populations where the frequency of seropositive individuals is influenced by such factors as age, sex and socio-economic conditions. While this virus causes such diseases as mononucleosis, it is also implicated in autoimmune ... | Human cytomegalovirus. A review of developments between 1970 and 1976. I. Clinical developments. Cytomegalovirus (CMV), like other members of the herpesviruses, is widely distributed in human populations where the frequency of seropositive individuals is influenced by such factors as age, sex and socio-economic conditi... | [
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PMID:16672 | The effects of adrenergic agonists and blockers on antigen-induced DNA synthesis in vitro. | The effects of both alpha and beta adrenergic agonists and blockers on antigen-stimulated DNA synthesis in human lymphocyte cultures were studied. Results show that antigen-induced responses were enhanced by the presence of the beta blockers, propranolol and dichloroisoproterenol, and that this effect appeared to be sp... | The effects of adrenergic agonists and blockers on antigen-induced DNA synthesis in vitro. The effects of both alpha and beta adrenergic agonists and blockers on antigen-stimulated DNA synthesis in human lymphocyte cultures were studied. Results show that antigen-induced responses were enhanced by the presence of the b... | [
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PMID:16674 | [Lactic acid as a factor in altering vascular reactivity]. | It was shown that the constrictor responses to the electrostimulation of the isolated vessel segments were replaced by dilatation when the drugs were contained in the lactic acid solution. The capacity to constrictor effects was not lost completely, but these effects appeared in repsonse to the intensive stimulation. C... | [Lactic acid as a factor in altering vascular reactivity]. It was shown that the constrictor responses to the electrostimulation of the isolated vessel segments were replaced by dilatation when the drugs were contained in the lactic acid solution. The capacity to constrictor effects was not lost completely, but these ... | [
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PMID:16675 | [Graft vs host reaction in reciprocal combinations of mouse strains differing by the H-2 complex of histocompatibility]. | Intraperitoneal transplantation of 0.5 x 10(7), 1 x 10(7) or 2 x 10(7) spleen cells from the C57BL mice to newborn CBA recipients induced an acute form or runt disease which resulted in the death of 43%, 86% or 95% of the recipient mice, respectively, in the course of 2--3 weeks after the cell transfer. Preliminary imm... | [Graft vs host reaction in reciprocal combinations of mouse strains differing by the H-2 complex of histocompatibility]. Intraperitoneal transplantation of 0.5 x 10(7), 1 x 10(7) or 2 x 10(7) spleen cells from the C57BL mice to newborn CBA recipients induced an acute form or runt disease which resulted in the death of ... | [
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PMID:16681 | Blood pressure and heart rate and withdrawal of antihypertensive drugs. | The immediate effects on heart rate and blood pressure of withdrawing antihypertensive drugs were studied over three-day periods in 26 patients. Four groups of drugs were studied. After withdrawal all patients taking clonidine showed a considerable increase in heart rate and blood pressure with intense ectopic activity... | Blood pressure and heart rate and withdrawal of antihypertensive drugs. The immediate effects on heart rate and blood pressure of withdrawing antihypertensive drugs were studied over three-day periods in 26 patients. Four groups of drugs were studied. After withdrawal all patients taking clonidine showed a considerable... | [
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PMID:16678 | [Blood gas measurements and automatization (author's transl)]. | The Corning 175, a fully automatic new blood-gas analyzer, was tested and compared with manual analyzers (Eschweiler-Radiometer). The precision was evaluated by means of tonometered bloods and precision gas mixtures. With the Corning 175 four parameters are measured: pH, PCO2, PO2, barometric pressure, and four compute... | [Blood gas measurements and automatization (author's transl)]. The Corning 175, a fully automatic new blood-gas analyzer, was tested and compared with manual analyzers (Eschweiler-Radiometer). The precision was evaluated by means of tonometered bloods and precision gas mixtures. With the Corning 175 four parameters are... | [
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PMID:16685 | Transmitter histochemistry of the rat olfactory bulb. I. Immunohistochemical localization of monoamine synthesizing enzymes. Support for intrabulbar, periglomerular dopamine neurons. | The rat olfactory bulb was studied at the light and electron microscopic level with the indirect immunofluorescence technique and the unlabelled antibody enzyme method (PAP-technique), respectively. Antibodies to all 4 enzymes in the catecholamine synthesis were used. In the principal bulb the first two enzymes, tyrosi... | Transmitter histochemistry of the rat olfactory bulb. I. Immunohistochemical localization of monoamine synthesizing enzymes. Support for intrabulbar, periglomerular dopamine neurons. The rat olfactory bulb was studied at the light and electron microscopic level with the indirect immunofluorescence technique and the unl... | [
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PMID:16686 | Striatal lesions with kainic acid: neurochemical characteristics. | Stereotaxic injection of 2.5 microng of kainic acid, a rigid analogue of glutamate into the rat striatum caused a 70% reduction in the striatum of the cholinergic parameters, choline acetyltransferase, acetylcholine and synaptosomal uptake of choline and a similar reduction in the GABAergic parameters, glutamic acid de... | Striatal lesions with kainic acid: neurochemical characteristics. Stereotaxic injection of 2.5 microng of kainic acid, a rigid analogue of glutamate into the rat striatum caused a 70% reduction in the striatum of the cholinergic parameters, choline acetyltransferase, acetylcholine and synaptosomal uptake of choline and... | [
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PMID:16690 | Methylamine dehydrogenase from the obligate methylotroph Methylomonas methylovora. | An obligate methyltroph Methylomonas methylovora oxidized methylamine, formaldehyde, and formate. Enzymes oxidizing these substrates were detected in a cell-free system. Phenazine methosulfate-linked methylamine dehydrogenase was purified 21-fold. The enzyme had optimum activity at pH 7.5 and was stable at 60 degrees C... | Methylamine dehydrogenase from the obligate methylotroph Methylomonas methylovora. An obligate methyltroph Methylomonas methylovora oxidized methylamine, formaldehyde, and formate. Enzymes oxidizing these substrates were detected in a cell-free system. Phenazine methosulfate-linked methylamine dehydrogenase was purifie... | [
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PMID:16691 | Partial purification and some properties of a neutral sulfhydryl and an acid proteinase from Entamoeba histolytica. | The partial purification of two intracellular proteinases from the protozoan parasite Entamoeba histolytica is reported. One of these enzymes is an acid proteinase exhibiting maximum activity at pH 3.5 (hemoglobin substrate), is little affected by a range of inhibitors or activators, and is presumed to be similar to ca... | Partial purification and some properties of a neutral sulfhydryl and an acid proteinase from Entamoeba histolytica. The partial purification of two intracellular proteinases from the protozoan parasite Entamoeba histolytica is reported. One of these enzymes is an acid proteinase exhibiting maximum activity at pH 3.5 (h... | [
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PMID:16692 | Lawnmower injuries in children. | Over an 8-year period 31 children in the Winnipeg area were admitted to hospital with lawnmower injuries. The accidents were always preventable and were caused by patient or parent carelessness. The wounds were severe, often resulting in amputation of a portion of an extremity. Infection was common; prophylaxis with a ... | Lawnmower injuries in children. Over an 8-year period 31 children in the Winnipeg area were admitted to hospital with lawnmower injuries. The accidents were always preventable and were caused by patient or parent carelessness. The wounds were severe, often resulting in amputation of a portion of an extremity. Infection... | [
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PMID:16694 | An endo-(1 leads to 3)-beta-D-glucanase from Mucor hiemalis. | An endo-(1 leads to 3)-beta-D-glucanase (EC 3.2.1.6), isolated from the culture filtrate of the fungus Mucor hiemalis, was purified by ammonium sulfate fractionation, gel filtration, and column chromatography on O-(carboxymethyl)cellulose. The optimum pH, optimum temperature, and Km value of the enzyme were pH 5.0, 50 ... | An endo-(1 leads to 3)-beta-D-glucanase from Mucor hiemalis. An endo-(1 leads to 3)-beta-D-glucanase (EC 3.2.1.6), isolated from the culture filtrate of the fungus Mucor hiemalis, was purified by ammonium sulfate fractionation, gel filtration, and column chromatography on O-(carboxymethyl)cellulose. The optimum pH, opt... | [
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PMID:16701 | Effect of streptovaricin on the incorporation of uridine into cellular and viral RNA. | Poxvirus replication is inhibited by streptovaricin. The most readily observed effect is the inhibition of incorporation of [3H]uridine into viral mRNA, suggesting an inhibition of RNA synthesis. Streptovaricin also inhibits the incorporation of [3H]uridine into cellular RNA but not as severely as viral RNA. On the oth... | Effect of streptovaricin on the incorporation of uridine into cellular and viral RNA. Poxvirus replication is inhibited by streptovaricin. The most readily observed effect is the inhibition of incorporation of [3H]uridine into viral mRNA, suggesting an inhibition of RNA synthesis. Streptovaricin also inhibits the incor... | [
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PMID:16704 | [Control of pituitary secretion of melanotropin in an anuran amphibian by thyrotropin releasing factor (TRH). Study in vitro]. | Intermediate lobes from Rana esculenta pituitary glands were continuously superfused for 7 hrs at 28 degrees C with amphibian culture medium. alpha-MSH release was measured by use of a sensitive double antibody radio-immunoassay system. alpha-MSH secretion was inhibited by low temperatures. A large increase in alpha-MS... | [Control of pituitary secretion of melanotropin in an anuran amphibian by thyrotropin releasing factor (TRH). Study in vitro]. Intermediate lobes from Rana esculenta pituitary glands were continuously superfused for 7 hrs at 28 degrees C with amphibian culture medium. alpha-MSH release was measured by use of a sensitiv... | [
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PMID:16705 | [Spontaneous phospholipase A activity of rat pancreatic homogenates]. | Rat pancreas presents a spontaneous phospholipase A activity which appears before trypsin activation at optimal pH 6.5. The responsible enzyme is independent of pancreatic prophospholipase A, as can be seen through experiments done in the presence of trypsin inhibitors. On the other hand, this enzyme is distinct from e... | [Spontaneous phospholipase A activity of rat pancreatic homogenates]. Rat pancreas presents a spontaneous phospholipase A activity which appears before trypsin activation at optimal pH 6.5. The responsible enzyme is independent of pancreatic prophospholipase A, as can be seen through experiments done in the presence of... | [
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PMID:16707 | Studies on alkaline phosphatase isoenzymes. Relation to gamma-glutamyltransferase and lactate dehydrogenase isoenzymes. | Gamma-Glutamyltransferase (GT) and isoenzymes of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) have been studied in 282 cases with increased S-ALP and in 18 chronic alcoholics with normal routine liver tests. There was a high degree of correlation between S-GT and the bile (alpha 1) and liver (alpha 2) fra... | Studies on alkaline phosphatase isoenzymes. Relation to gamma-glutamyltransferase and lactate dehydrogenase isoenzymes. Gamma-Glutamyltransferase (GT) and isoenzymes of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) have been studied in 282 cases with increased S-ALP and in 18 chronic alcoholics with normal... | [
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PMID:16703 | [Incidence of Arbovirus isolated from mosquitoes in the forest region of South Cameroun, region of Yaoundé ]. | The authors give results of a survey of arboviruses isolated from mosquitoes in the neighborhood of Yaoundé, Southern Cameroon, from 1964 to 1972. During this period of nine years 127.520 female mosquitoes including at least 72 species were collected and processed for attempt of virus isolation. 55 strains belonging to... | [Incidence of Arbovirus isolated from mosquitoes in the forest region of South Cameroun, region of Yaoundé ]. The authors give results of a survey of arboviruses isolated from mosquitoes in the neighborhood of Yaoundé, Southern Cameroon, from 1964 to 1972. During this period of nine years 127.520 female mosquitoes incl... | [
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PMID:16708 | Comparison of human membrane-bound neutral arylamidases from small intestine, lung, kidney, liver and placenta. | Human membrane-bound neutral arylamidases were solubilized from small intestinal mucosa, lung, kidney, liver and placenta with trypsin. These five membrane-bound neutral arylamidases were identified by polyacrylamide gel-disc electrophoresis. The heat sensitivity of each enzyme was in the order, liver and placenta grea... | Comparison of human membrane-bound neutral arylamidases from small intestine, lung, kidney, liver and placenta. Human membrane-bound neutral arylamidases were solubilized from small intestinal mucosa, lung, kidney, liver and placenta with trypsin. These five membrane-bound neutral arylamidases were identified by polyac... | [
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PMID:16711 | Anti-tumour immunity by normal allogeneic blood transfusion in rat. | Growth of transplantable KMT-17 tumour in syngeneic WKA/MK rats was inhibited by i.v. preimmunization with whole blood from normal rats of allogeneic strains. The inhibitory effect was also observed in rats immunized with allogeneic white blood cells alone. The strength of the inhibitory effect mainly depended on the t... | Anti-tumour immunity by normal allogeneic blood transfusion in rat. Growth of transplantable KMT-17 tumour in syngeneic WKA/MK rats was inhibited by i.v. preimmunization with whole blood from normal rats of allogeneic strains. The inhibitory effect was also observed in rats immunized with allogeneic white blood cells a... | [
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PMID:16712 | The immune reponse to type III pneumococcal polysaccharide in mice with malaria. | The immune response of BALB/c mice to type III pneumococcal polysaccharide (SIII), as measured by splenic PFC, was abolished at the height of an acute self-limiting attack of malaria caused by the murine plasmodium P. yoelii, over a wide range of antigen doses. The response to antigen, given at various times after clin... | The immune reponse to type III pneumococcal polysaccharide in mice with malaria. The immune response of BALB/c mice to type III pneumococcal polysaccharide (SIII), as measured by splenic PFC, was abolished at the height of an acute self-limiting attack of malaria caused by the murine plasmodium P. yoelii, over a wide r... | [
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PMID:16716 | Beta-2 adrenoceptor blocking activity of penbutolol and propranolol at very low doses. | The relative potency of penbutolol, a new beta adrenergic receptor blocking agent, was compared with propranolol by a four-point assay on healthy male subjects. A dose-response relationship to intravenous doses of propranolol in the microgram range was obtained during a steady state of infusion of epinephrine. Two subj... | Beta-2 adrenoceptor blocking activity of penbutolol and propranolol at very low doses. The relative potency of penbutolol, a new beta adrenergic receptor blocking agent, was compared with propranolol by a four-point assay on healthy male subjects. A dose-response relationship to intravenous doses of propranolol in the ... | [
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PMID:16717 | Cardiovascular effects of total hip placement in man. With observations on the effects of methylmethacrylate on the isolated rabbit heart. | The cardiovascular effects of total hip placement were evaluated in 10 surgical patients, aged 55 to 82, while receiving fluroxene-N2O-O2 anesthesia. The anesthetic regimen caused mild cardiovascular depression. The placement of the acrylic cement into the acetabulum and femoral shaft also induced mild cardiovascular d... | Cardiovascular effects of total hip placement in man. With observations on the effects of methylmethacrylate on the isolated rabbit heart. The cardiovascular effects of total hip placement were evaluated in 10 surgical patients, aged 55 to 82, while receiving fluroxene-N2O-O2 anesthesia. The anesthetic regimen caused m... | [
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PMID:16718 | Erythrocyte adenosine triphosphate and 2,3-diphosphoglycerate after human renal transplantation: dissociation from hypophosphataemia. | 1. Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP) were determined in normal individuals, uraemic patients on chronic haemodialysis and patients who underwent renal transplantation, and correlated with plasma phosphate and arterial blood pH. 2. Significant increases in the 2,3-DPG and ATP ... | Erythrocyte adenosine triphosphate and 2,3-diphosphoglycerate after human renal transplantation: dissociation from hypophosphataemia. 1. Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP) were determined in normal individuals, uraemic patients on chronic haemodialysis and patients who underwe... | [
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PMID:16731 | A study of the in vitro and in vivo interaction of barium sulphate particles with gastro-intestinal mucus. | The in vivo interaction of various radiopaques with mucus was investigated by a determination of the pH-mobility curves of the treated particles. It was found that mucus covered the radiopaque particles both in vivo and in vitro. This interaction was not affected by the nature of the radiopaque or by the state of the m... | A study of the in vitro and in vivo interaction of barium sulphate particles with gastro-intestinal mucus. The in vivo interaction of various radiopaques with mucus was investigated by a determination of the pH-mobility curves of the treated particles. It was found that mucus covered the radiopaque particles both in vi... | [
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PMID:16732 | In vitro efficacy of some drugs on promastigotes of Leishmania donovani. | Sodium stibogluconate, metronidazole and dehydroemetine Roche were tested for their in vitro action on the mobility, morphology and survival of promastigotes of Leishmania donovani. At low concentrations, sodium stibogluconate, the drug of choice for kala azar treatment in Iraq proved to be poorly effective in the pre... | In vitro efficacy of some drugs on promastigotes of Leishmania donovani. Sodium stibogluconate, metronidazole and dehydroemetine Roche were tested for their in vitro action on the mobility, morphology and survival of promastigotes of Leishmania donovani. At low concentrations, sodium stibogluconate, the drug of choice... | [
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PMID:16733 | [The influence of surgery on serum enzyme changes]. | Gamma-GT, which appears as a sensitive indicator in the enzyme pattern during postoperative examination, is especially recommended (besides the GOT and GPT enzymes) in detecting and watching the course of hepatocellular lesions. Distinction between parenchymatous and obstructive icterus can in some cases be made at an ... | [The influence of surgery on serum enzyme changes]. Gamma-GT, which appears as a sensitive indicator in the enzyme pattern during postoperative examination, is especially recommended (besides the GOT and GPT enzymes) in detecting and watching the course of hepatocellular lesions. Distinction between parenchymatous and ... | [
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PMID:16729 | Spontaneous variability of the hemoglobin affinity for oxygen. | In order to evaluate the accuracy of our method of P50 determination, we measured P50 and 2,3-DPG on different days on several members of our laboratory staff and were surprised to find significant variation. Initially, we indicted our methodology but subsequent data suggest that significant P50 variability occurs, not... | Spontaneous variability of the hemoglobin affinity for oxygen. In order to evaluate the accuracy of our method of P50 determination, we measured P50 and 2,3-DPG on different days on several members of our laboratory staff and were surprised to find significant variation. Initially, we indicted our methodology but subse... | [
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PMID:16734 | Tardive dyskinesia: relationship with a primary affective disorder. | We reviewed all Mayo Clinic case histories in which a diagnosis of tardive dyskinesia or dyskinesia might have been recorded during the years 1965 through 1973 and interviewed 18 consecutive patients in the Department of Psychiatry and Psychology. Among the histories and patients, we found a high incidence of primary ... | Tardive dyskinesia: relationship with a primary affective disorder. We reviewed all Mayo Clinic case histories in which a diagnosis of tardive dyskinesia or dyskinesia might have been recorded during the years 1965 through 1973 and interviewed 18 consecutive patients in the Department of Psychiatry and Psychology. Amo... | [
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PMID:16730 | Oxygen availability during hypothermic cardiopulmonary bypass. | Oxygen availability during cardiopulmonary bypass was assessed in 22 patients under hypothermic and relatively normothermic conditions. The patients were divided into two groups, 17 of whom received ACD blood and 5, CPD blood. The mean P50 for all patients fell from a preoperative value of 25.9 +/- 2.4 (SD) to 15.6 +/-... | Oxygen availability during hypothermic cardiopulmonary bypass. Oxygen availability during cardiopulmonary bypass was assessed in 22 patients under hypothermic and relatively normothermic conditions. The patients were divided into two groups, 17 of whom received ACD blood and 5, CPD blood. The mean P50 for all patients ... | [
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PMID:16735 | Multi-clinic cross-over comparison of triazolam (Halcion) and placebo in the treatment of co-existing insomnia and anxiety in anxious out-patients. | In this multi-clinic double-blind cross-over designed study, forty-five anxious and insomniac out-patients received either triazolam (Halcion) 0.25 mg or placebo at bedtime. After seven days the medications were crossed over. The dosage was doubled after nights 2 and 9 if good sleep was not produced. Three patients dro... | Multi-clinic cross-over comparison of triazolam (Halcion) and placebo in the treatment of co-existing insomnia and anxiety in anxious out-patients. In this multi-clinic double-blind cross-over designed study, forty-five anxious and insomniac out-patients received either triazolam (Halcion) 0.25 mg or placebo at bedtime... | [
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PMID:16736 | Interactions with antiepileptic drugs. | Most of the currently available antiepileptic drugs have a low therapeutic ratio and therefore a drug interaction causing elevation of the serum level of one of these compounds can readily lead to drug intoxication. Phenytoin, in particular, is vulnerable because its metabolism is dose-related and at therapeutic serum ... | Interactions with antiepileptic drugs. Most of the currently available antiepileptic drugs have a low therapeutic ratio and therefore a drug interaction causing elevation of the serum level of one of these compounds can readily lead to drug intoxication. Phenytoin, in particular, is vulnerable because its metabolism is... | [
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PMID:16740 | [Sugar studies at Turku]. | This survey concerns the essential findings in two clinical trials. The first study involved almost complete substitution of sucrose (S) by fructose (F) or xylitol (X). After 2 years the mean DMFS-increment was 7.2 in the S-group, 3.8 in the F-group, and 0.0 in the X-group. The second study comprised partial substituti... | [Sugar studies at Turku]. This survey concerns the essential findings in two clinical trials. The first study involved almost complete substitution of sucrose (S) by fructose (F) or xylitol (X). After 2 years the mean DMFS-increment was 7.2 in the S-group, 3.8 in the F-group, and 0.0 in the X-group. The second study co... | [
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PMID:16742 | The effects of dopamine on renin release in vitro. | To examine the direct effects of dopamine on renin release, the in vitro rat kidney slice system, devoid of hemodynamic and humoral effects, was chosen. In the presence of an antioxidant, ascorbic acid (6 X 10(-4)M), a significant dose-related stimulation of renin release was observed with addition of 10(-5)M and highe... | The effects of dopamine on renin release in vitro. To examine the direct effects of dopamine on renin release, the in vitro rat kidney slice system, devoid of hemodynamic and humoral effects, was chosen. In the presence of an antioxidant, ascorbic acid (6 X 10(-4)M), a significant dose-related stimulation of renin rele... | [
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PMID:16743 | Diagnosis of bilateral abdominal cryptorchidism by laparoscopy. | The authors report a case of abdominal retention of both testes, where the exact diagnosis was made by laparoscopy. They suggest the usefulness of laparoscopy also in urology. | Diagnosis of bilateral abdominal cryptorchidism by laparoscopy. The authors report a case of abdominal retention of both testes, where the exact diagnosis was made by laparoscopy. They suggest the usefulness of laparoscopy also in urology. | [
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PMID:16744 | An approach to the toxicology of combustion products of materials. | Physiological and behavioral (conditioned avoidance) responses of male Long-Evans rats were determined during exposure to combustion products produced on thermal degradation of three different polymeric materials. Arterial blood samples were obtained for determination of carboxyhemoglobin (COHb) and acid/base status. M... | An approach to the toxicology of combustion products of materials. Physiological and behavioral (conditioned avoidance) responses of male Long-Evans rats were determined during exposure to combustion products produced on thermal degradation of three different polymeric materials. Arterial blood samples were obtained fo... | [
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PMID:16745 | Development of hepatic acetyl coenzyme A carboxylase in hormone-treated chicks. | It has been suggested that the carbohydrate-rich diet of chicks after hatching is responsible for the emergence of hepatic enzymes involved in lipogenesis; the injection of glucose to newly hatched chicks gives rise to an appreciable elvation on the activities of acetyl coenzyme A carboxylase and fatty acid synthetase.... | Development of hepatic acetyl coenzyme A carboxylase in hormone-treated chicks. It has been suggested that the carbohydrate-rich diet of chicks after hatching is responsible for the emergence of hepatic enzymes involved in lipogenesis; the injection of glucose to newly hatched chicks gives rise to an appreciable elvati... | [
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PMID:16747 | The energy metabolism of the leukocyte. IX. Changes in the concentration of the coenzymes NAD, NADH, NADP, and NADPH in polymorphonuclear leukocytes during phagocytosis of Staphylococcus albus and due to the action of phospholipase C. | The determination of the coenzymes NAD+, NADH, NADP+ and NADPH, by the use of a method of enzymatic cycling, demonstrates that the enzymes responsible for the stimulations found during the phagocytosis of Staphylococcus albus are NADH and NADPH oxidase of human leukocytes and NADPH oxidase in the case of guinea pig leu... | The energy metabolism of the leukocyte. IX. Changes in the concentration of the coenzymes NAD, NADH, NADP, and NADPH in polymorphonuclear leukocytes during phagocytosis of Staphylococcus albus and due to the action of phospholipase C. The determination of the coenzymes NAD+, NADH, NADP+ and NADPH, by the use of a metho... | [
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PMID:16748 | Tissue distribution and blood levels of gamma-glutamyl transferase in the horse. | In the horse, gamma-glutamyl transferase (GGT) was found to be mainly located in the kidneys, liver and pancreas. As renal lesions are followed by a urinary escape of enzyme, it can be assumed that if there are raised serum enzyme levels then the source will be chiefly from the liver and pancreas. In the blood, GGT can... | Tissue distribution and blood levels of gamma-glutamyl transferase in the horse. In the horse, gamma-glutamyl transferase (GGT) was found to be mainly located in the kidneys, liver and pancreas. As renal lesions are followed by a urinary escape of enzyme, it can be assumed that if there are raised serum enzyme levels t... | [
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PMID:16750 | An isolation procedure for the native alpha chain of bovine hemoglobin. A study of the functional properties of this chain and its hybrid with the human beta chain. | In this paper we present a procedure for the isolation of the native bovine alpha chain. The method is based on affinity chromatography. The results show that the ligand-binding properties of the bovine alpha chain are almost identical to those of the human alpha chain. The hybrid alphaB2 betaH2 prepared by mixing bovi... | An isolation procedure for the native alpha chain of bovine hemoglobin. A study of the functional properties of this chain and its hybrid with the human beta chain. In this paper we present a procedure for the isolation of the native bovine alpha chain. The method is based on affinity chromatography. The results show t... | [
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PMID:16751 | Uridine phosphorylase from Escherichia coli. Physical and chemical characterization. | Uridine phosphorylase from Escherichia coli has been purified to homogeneity. The enzyme was found to have a molecular weight of 176000 and to consist of 8 probably identical subunits with molecular weights of 22000. These numbers were determined from equilibrium centrifugations in the analytical ultracentrifuge, from ... | Uridine phosphorylase from Escherichia coli. Physical and chemical characterization. Uridine phosphorylase from Escherichia coli has been purified to homogeneity. The enzyme was found to have a molecular weight of 176000 and to consist of 8 probably identical subunits with molecular weights of 22000. These numbers were... | [
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PMID:16752 | The exchange reaction of peptides R-D-alanyl-D-alanine with D-[14C]alanine to R-D-alanyl-D-[14C]alanine and D-alanine, catalysed by the membranes of Streptococcus faecalis ATCC 9790. | Under alkaline conditions, the membrane-bound DD-carboxypeptidase of Streptococcus faecalis ATCC 9790 catalyses exchange reactions in which the X-L-R3-D-Ala moiety of peptides of the type X-L-R3-D-Ala-D-Ala is transferred to simple amino compounds such as D-alanine, glycine and glycyl-glycine. The enzyme system is unab... | The exchange reaction of peptides R-D-alanyl-D-alanine with D-[14C]alanine to R-D-alanyl-D-[14C]alanine and D-alanine, catalysed by the membranes of Streptococcus faecalis ATCC 9790. Under alkaline conditions, the membrane-bound DD-carboxypeptidase of Streptococcus faecalis ATCC 9790 catalyses exchange reactions in whi... | [
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PMID:16753 | The phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus aureus. 3. 1H and 31P nuclear-magnetic-resonance studies on the phosphocarrier protein HPr; tyrosine titration and denaturation studies. | The phosphocarrier protein HPr has been investigated by proton nuclear magnetic resonance (NMR) at 270 MHz in order to evaluate structural properties of the whole molecule and its active site. The titration behaviour of the three tyrosines of the HPr protein was analysed by monitoring the chemical shifts of the aromati... | The phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus aureus. 3. 1H and 31P nuclear-magnetic-resonance studies on the phosphocarrier protein HPr; tyrosine titration and denaturation studies. The phosphocarrier protein HPr has been investigated by proton nuclear magnetic resonance (NMR) at 270 MH... | [
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PMID:16755 | Stability in vitro of methylproscillaridin. | The in vitro stability of methylproscillaridin has been compared with that of proscillaridin, the activities of the glycosides being assayed by the 86Rb-technique. After incubation in gastric juice at pH 1,2, and 3, the activity half life of each glycoside was proportional to pH and was approximately 0.25 h, 2.5 h, and... | Stability in vitro of methylproscillaridin. The in vitro stability of methylproscillaridin has been compared with that of proscillaridin, the activities of the glycosides being assayed by the 86Rb-technique. After incubation in gastric juice at pH 1,2, and 3, the activity half life of each glycoside was proportional to... | [
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PMID:16756 | The effect of LSD and 2-bromo LSD on the striatal DOPA accumulation after decarboxylase inhibition in rats. | LSD and BOL (0.125-0.5 mg/kg) were equipotent in increasing the in vivo tyrosine hydroxylation in the striatum as measured by the accumulation of DOPA after inhibition of neuronal decarboxylase. However, with 2--4 mg/kg doses, the maximum effect of BOL was larger than that of LSD. LSD and BOL antagonized the apomorphin... | The effect of LSD and 2-bromo LSD on the striatal DOPA accumulation after decarboxylase inhibition in rats. LSD and BOL (0.125-0.5 mg/kg) were equipotent in increasing the in vivo tyrosine hydroxylation in the striatum as measured by the accumulation of DOPA after inhibition of neuronal decarboxylase. However, with 2--... | [
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PMID:16757 | Vascular beta-adrenoceptor stimulating properties of phenylephrine. | In pithed rats pretreated with propranolol changes occurred in the slopes of dose--pressor response curves to i.v. phenylephrine and noradrenaline but not to LD 3098, a pure alpha-adrenoceptor stimulant. In dogs, cats, and spontaneously hypertensive rats pretreated with an alpha-adrenoceptor blocker, i.v. phenylephrine... | Vascular beta-adrenoceptor stimulating properties of phenylephrine. In pithed rats pretreated with propranolol changes occurred in the slopes of dose--pressor response curves to i.v. phenylephrine and noradrenaline but not to LD 3098, a pure alpha-adrenoceptor stimulant. In dogs, cats, and spontaneously hypertensive ra... | [
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PMID:16767 | Subpopulations of T-lymphocytes in Peyer's patches: sensitivity to antilymphocyte serum and adult thymectomy. | Anti-lymphocyte (ALS) treatment or adult thymectomy of the donor have been shown to depress respectively the cell proliferation and the cytotoxicity in the graft-versus-host (GVH) reaction. A quantitative assay and the histological criteria of the GVH reaction have been used to demonstrate that all the known subpopulat... | Subpopulations of T-lymphocytes in Peyer's patches: sensitivity to antilymphocyte serum and adult thymectomy. Anti-lymphocyte (ALS) treatment or adult thymectomy of the donor have been shown to depress respectively the cell proliferation and the cytotoxicity in the graft-versus-host (GVH) reaction. A quantitative assay... | [
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PMID:16769 | Correlation between serum dopamine-beta-hydroxylase activity and dopamine-beta-hydroxylase and tyrosine hydroxylase activities in central and peripheral adrenergic neurons and adrenal glands. | Serum dopamine-beta-hydroxylase activity in spontaneously hypertensive rats and Wistar-Kyoto rats had a positive correlation with dopamine-beta-hydroxylase and tyrosine hydroxylase activities in mesenteric vessels, vas deferens, and adrenal glands at 14-16 weeks of age, a negative correlation with dopamine-beta-hydroxy... | Correlation between serum dopamine-beta-hydroxylase activity and dopamine-beta-hydroxylase and tyrosine hydroxylase activities in central and peripheral adrenergic neurons and adrenal glands. Serum dopamine-beta-hydroxylase activity in spontaneously hypertensive rats and Wistar-Kyoto rats had a positive correlation wit... | [
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PMID:16776 | Specific metabolic pathway in vitro of pinazepam and diazepam by liver microsomal enzymes of different animal species. | The metabolic pathway of Pinazepam and Diazepam in vitro was studied with rat, guinea pig and dog liver microsomes using a chromatographic and spectrophotometric technique. Two main pathways were observed, N1-dealkylation and C3-hydroxylation. N1-dealkylation was shown to be the predominant reaction for Pinazepam in al... | Specific metabolic pathway in vitro of pinazepam and diazepam by liver microsomal enzymes of different animal species. The metabolic pathway of Pinazepam and Diazepam in vitro was studied with rat, guinea pig and dog liver microsomes using a chromatographic and spectrophotometric technique. Two main pathways were obser... | [
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PMID:16774 | [Mechanism of the action of apressin under conditions of high temperature and physical exertion]. | In experiments on rats subject to study were regularities governing the metabolism of glycogen, milk, pyruvic acid, phosphocreatine in the liver tissues, cortex, musculus gastrocnemius and in the myocardium, as well as of acids in the peripheral blood at 40 degrees C of outside temperature, 95 per cent humidity and dur... | [Mechanism of the action of apressin under conditions of high temperature and physical exertion]. In experiments on rats subject to study were regularities governing the metabolism of glycogen, milk, pyruvic acid, phosphocreatine in the liver tissues, cortex, musculus gastrocnemius and in the myocardium, as well as of ... | [
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PMID:16775 | [Sulfaphenazole binding by p-450 cytochrome of liver microsomes of rats and its effect of cytochrome-p-450-reductase]. | Tests set up "in vitro" on the rats' liver microsomes showed that sulfaphenazol, which in an inhibitor of the mixed type N-and O-demethylation, is bound as a substrate of the II type (aniline type). It attenuates spectral changes caused by aniline and vice versa. Sulfaphenazol inhibits the activity of the ADPH cytochro... | [Sulfaphenazole binding by p-450 cytochrome of liver microsomes of rats and its effect of cytochrome-p-450-reductase]. Tests set up "in vitro" on the rats' liver microsomes showed that sulfaphenazol, which in an inhibitor of the mixed type N-and O-demethylation, is bound as a substrate of the II type (aniline type). It... | [
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PMID:16782 | Regulation of gastric acid secretion. | The advent of the H2-histamine-receptor antagonists has given new life to the old hypothesis that histamine might be the final common chemical mediator of acid secretion. The available evidence, however, does not prove this hypothesis but does confer on histamine a role in the regulation of acid secretion in normal phy... | Regulation of gastric acid secretion. The advent of the H2-histamine-receptor antagonists has given new life to the old hypothesis that histamine might be the final common chemical mediator of acid secretion. The available evidence, however, does not prove this hypothesis but does confer on histamine a role in the regu... | [
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PMID:16783 | Localization of hypophysiotropic neurohormones by assay of sections from various brain areas. | The results of studies of the localization of the hypothalamic hypophysiotropic factors based on their direct determination in sections or nuclear punches are described. Luteinizing hormone-releasing hormone was found in high concentrations in the median eminence-arcuate nucleus complex, in lower concentrations in the ... | Localization of hypophysiotropic neurohormones by assay of sections from various brain areas. The results of studies of the localization of the hypothalamic hypophysiotropic factors based on their direct determination in sections or nuclear punches are described. Luteinizing hormone-releasing hormone was found in high ... | [
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PMID:16787 | Lysis of periadnexal adhesions for correction of infertility. | A series of patients is presented in whom lysis of periadnexal adhesions was carried out for correction of infertility. These 35 couples had been infertile for at least 1 year prior to surgery. Seventy-seven per cent had been trying to conceive for more than 18 months. Following diagnostic evaluation, periadnexal adhes... | Lysis of periadnexal adhesions for correction of infertility. A series of patients is presented in whom lysis of periadnexal adhesions was carried out for correction of infertility. These 35 couples had been infertile for at least 1 year prior to surgery. Seventy-seven per cent had been trying to conceive for more than... | [
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PMID:16791 | Double-blind placebo-controlled efficacy study of ketazolam (U-28,774). | The safety and efficacy of ketazolam (15 mg capsules) was compared to placebo in seventy-nine out-patients suffering from psychoneurotic anxiety, moderate or worse in severity. A flexible dosage range of 15-75 mg was used in this double-blind study lasting twenty-eight days. The average optimum therapeutic dose of keta... | Double-blind placebo-controlled efficacy study of ketazolam (U-28,774). The safety and efficacy of ketazolam (15 mg capsules) was compared to placebo in seventy-nine out-patients suffering from psychoneurotic anxiety, moderate or worse in severity. A flexible dosage range of 15-75 mg was used in this double-blind study... | [
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PMID:16792 | Hypnotic efficacy of triazolam and methyprylon ininsomniac in-patients. | The hypnotic effects of a new triazolobenzodiazepine, triazolam (Halcion) 0-5 mg and methyprylon 300 mg was compared in twenty oncologic in-patient volunteers with insomnia using the preference technique. On the first night of the two-night trial, or methyprylon was given on a double-blind basis and on the second night... | Hypnotic efficacy of triazolam and methyprylon ininsomniac in-patients. The hypnotic effects of a new triazolobenzodiazepine, triazolam (Halcion) 0-5 mg and methyprylon 300 mg was compared in twenty oncologic in-patient volunteers with insomnia using the preference technique. On the first night of the two-night trial, ... | [
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PMID:16793 | Intermediate use of triazolam: a sleep laboratory study. | The present study was undertaken to evaluate the intermediate effects of triazolam 0-5 mg on the sleep of insomniac patients. The results showed that triazolam is effective in inducing and maintaining sleep without producing any major effects on sleep staging. Triazolam did not lead to significant subjective complaints... | Intermediate use of triazolam: a sleep laboratory study. The present study was undertaken to evaluate the intermediate effects of triazolam 0-5 mg on the sleep of insomniac patients. The results showed that triazolam is effective in inducing and maintaining sleep without producing any major effects on sleep staging. Tr... | [
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PMID:16794 | Psychometric assessment of the therapeutic efficiency of antidepressant agents. | A clinical trial of four weeks duration was conducted involving a total of thirty depressed patients, of both sexes, aged between twenty and thirty-four years. The total number of patients was divided into three groups of ten patients each. One group received amitriptyline, the second group was administered noxiptyline... | Psychometric assessment of the therapeutic efficiency of antidepressant agents. A clinical trial of four weeks duration was conducted involving a total of thirty depressed patients, of both sexes, aged between twenty and thirty-four years. The total number of patients was divided into three groups of ten patients each.... | [
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PMID:16795 | Some aspects of the pharmacology of analgesia. | This paper makes comparisons of some of the pharmacological properties of the opiate analgesics and the tricyclic antidepressants in order to justify the clinical examination of the tricyclics as potential analgesic or proanalgesic agents in man. Preliminary animal data suggest that the tricyclic agent clomipramine (An... | Some aspects of the pharmacology of analgesia. This paper makes comparisons of some of the pharmacological properties of the opiate analgesics and the tricyclic antidepressants in order to justify the clinical examination of the tricyclics as potential analgesic or proanalgesic agents in man. Preliminary animal data su... | [
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PMID:16796 | The use of psychotropic drugs in rheumatology. | The possible role of various psychotropic drugs in the management of rheumatic diseases is considered--tranquillizers, sedatives, tricyclic antidepressants and monoamine oxidase inhibitors. The dilemma of which anti-depressant for which patient is considered. The possible association between rheumatoid disease and diso... | The use of psychotropic drugs in rheumatology. The possible role of various psychotropic drugs in the management of rheumatic diseases is considered--tranquillizers, sedatives, tricyclic antidepressants and monoamine oxidase inhibitors. The dilemma of which anti-depressant for which patient is considered. The possible ... | [
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PMID:16797 | The use of psychotropic drugs in a pain clinic. | The paper is based on experiences gained at a hospital pain clinic. Patients attending such a pain clinic can be divided into three categories: (1) Those with chronic organic lesions in whom the mental state was little affected. (2) Those with organic lesions who had mental changes which influenced their experience of ... | The use of psychotropic drugs in a pain clinic. The paper is based on experiences gained at a hospital pain clinic. Patients attending such a pain clinic can be divided into three categories: (1) Those with chronic organic lesions in whom the mental state was little affected. (2) Those with organic lesions who had ment... | [
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PMID:16799 | Nefopam HCl interaction study with eight other drugs. | A controlled clinical trial was undertaken to determine potential for drug interaction of nefopam HCl, a new analgesic, with eight other widely used compounds. Nefopam HCl was administered in combination with these drugs and placebo to forty-five healthy volunteer subjects in nine groups of five subjects each. Possible... | Nefopam HCl interaction study with eight other drugs. A controlled clinical trial was undertaken to determine potential for drug interaction of nefopam HCl, a new analgesic, with eight other widely used compounds. Nefopam HCl was administered in combination with these drugs and placebo to forty-five healthy volunteer s... | [
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PMID:16800 | A comparative study of antidepressants in the treatment of depressive states. | The effect of six antidepressants has been investigated in six groups of twenty patients suffering from depressive states. The over-all response of the six groups, as well as the response of the individual target symptoms of depression according to the Hamilton Rating Scale are reported. | A comparative study of antidepressants in the treatment of depressive states. The effect of six antidepressants has been investigated in six groups of twenty patients suffering from depressive states. The over-all response of the six groups, as well as the response of the individual target symptoms of depression accord... | [
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PMID:16801 | Preference studies of triazolam with standard hypnotics in out-patients with insomnia. | One hundred and four patients suffering from insomnia took part in four different two-night double-blind crossover trials of triazolam. In three separate studies, triazolam 0-5 mg was compared to placebo, flurazepam 30 mg and chloral hydrate 500 mg. Triazolam 0-5 mg was found to be preferred and to be superior to place... | Preference studies of triazolam with standard hypnotics in out-patients with insomnia. One hundred and four patients suffering from insomnia took part in four different two-night double-blind crossover trials of triazolam. In three separate studies, triazolam 0-5 mg was compared to placebo, flurazepam 30 mg and chloral... | [
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PMID:16803 | The nocturnal intragastric pH in EEG sleep stages in peptic ulcer patients. | In 10 peptic ulcer patients, 5 duodenal ulcer and 5 gastric ulcer patients, the relation of nocturnal intragastric pH to EEG sleep stages was examined. The nocturnal intragastric pH was monitored by pH-measuring telemeter and sleep stages were recorded simultaneously by electroencephalography throughout the night. The ... | The nocturnal intragastric pH in EEG sleep stages in peptic ulcer patients. In 10 peptic ulcer patients, 5 duodenal ulcer and 5 gastric ulcer patients, the relation of nocturnal intragastric pH to EEG sleep stages was examined. The nocturnal intragastric pH was monitored by pH-measuring telemeter and sleep stages were ... | [
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PMID:16806 | Comparison of an H2 receptor antagonist and a neutralizing antacid on postprandial acid delivery into the duodenum in patients with duodenal ulcer. | Measurement of the postprandial rate of acid delivery into the duodenum directly assessed the efficacy of two radically different acid-reducing therapies for duodenal ulcer disease. Cimetidine, 400 mg, with an ordinary solid meal decreased the 4-hr delivery of titratable acid and hydrogen ion into the duodenum by 63 an... | Comparison of an H2 receptor antagonist and a neutralizing antacid on postprandial acid delivery into the duodenum in patients with duodenal ulcer. Measurement of the postprandial rate of acid delivery into the duodenum directly assessed the efficacy of two radically different acid-reducing therapies for duodenal ulcer... | [
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PMID:16807 | Aspirin esterase of gastric mucosal origin. | The enzyme, aspirin esterase, which converts acetylsalicyclic acid to the less toxic salicyclic acid, was found to be present in gastric mucosal specimens obtained from surgically resected tissue. The enzyme was found to be stable to storage and active at two pH optima. Alcohol in the reaction mixture produced a net ef... | Aspirin esterase of gastric mucosal origin. The enzyme, aspirin esterase, which converts acetylsalicyclic acid to the less toxic salicyclic acid, was found to be present in gastric mucosal specimens obtained from surgically resected tissue. The enzyme was found to be stable to storage and active at two pH optima. Alcoh... | [
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PMID:16812 | Ditazole and platelets. I. Effect of ditazole on human platelet function in vitro. | Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) has been shown to be a strong in vitro inhibitor of human platelet aggregation brought about by release reaction inducers; in contrast, it did not significantly affect primary ADP-induced aggregation. Ditazole strongly inhibited the release of platelet-bound 14... | Ditazole and platelets. I. Effect of ditazole on human platelet function in vitro. Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) has been shown to be a strong in vitro inhibitor of human platelet aggregation brought about by release reaction inducers; in contrast, it did not significantly affect primary AD... | [
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PMID:16809 | [Histamine 2 receptor antagonists in the treatment of gastric ulcer]. | Eight patients with a clinical, radiology and endoscopic diagnosis of benign peptic ulcer were studied in a prospective fashion using Cimetidine (H2-Receptor antagonist). With this outgoing form of therapy the need for antiacid diminished greatly and pain totally disappeared. We discuss the possible etiological pathway... | [Histamine 2 receptor antagonists in the treatment of gastric ulcer]. Eight patients with a clinical, radiology and endoscopic diagnosis of benign peptic ulcer were studied in a prospective fashion using Cimetidine (H2-Receptor antagonist). With this outgoing form of therapy the need for antiacid diminished greatly and... | [
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PMID:16814 | [Glucocorticoid action of beclomethasone and its propionate ester derivatives]. | In the present pharmacokinetic studies on beclomethasone dipropionate in rats, it was suggested that most of the beclomethasone-17, 21dipropionate is transformed rapidly into beclomethasone-17-monopropionate or beclomethasone in the blood or tissues and exerts the glucocorticoid effect in the form of beclomethasone. Gl... | [Glucocorticoid action of beclomethasone and its propionate ester derivatives]. In the present pharmacokinetic studies on beclomethasone dipropionate in rats, it was suggested that most of the beclomethasone-17, 21dipropionate is transformed rapidly into beclomethasone-17-monopropionate or beclomethasone in the blood o... | [
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PMID:16815 | A comparative clinical study for the evaluation of antianxiety agents, (lorazepam, diazepam and placebo), in neurosis. | To evaluate the clinical effects of lorazepam on neurosis, a double-blind controlled trial by group comparison procedure was carried out using diazepam and placebo as control drugs. The clinical improvement and aggravation rates by means of a variety of assessment of change were compared between each of the two active ... | A comparative clinical study for the evaluation of antianxiety agents, (lorazepam, diazepam and placebo), in neurosis. To evaluate the clinical effects of lorazepam on neurosis, a double-blind controlled trial by group comparison procedure was carried out using diazepam and placebo as control drugs. The clinical improv... | [
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PMID:16816 | [The regulation of FSH release by the testis. Studies on inhibin]. | The FSH release from the hypophysis is suggested to be particularly regulated by a testicular hormone called inhibin. Origin, structure and target organs of inhibin are unknown. Experiments to test some hypotheses in this field are described. Adult male rats, prenatally treated with busulfan, show only Sertoli cells in... | [The regulation of FSH release by the testis. Studies on inhibin]. The FSH release from the hypophysis is suggested to be particularly regulated by a testicular hormone called inhibin. Origin, structure and target organs of inhibin are unknown. Experiments to test some hypotheses in this field are described. Adult male... | [
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PMID:16818 | Suppression of ACTH secretion by synthetic MSH-release inhibiting factor Pro-Leu-Gly-NH2 in Addison's disease. | The regulation of release of MSH and ACTH seems to be closely related. The effect of Pro-Leu-Gly-NH2, the most active MSH-release inhibiting factor (MIF), was investigated on ACTH-hypersecretion in six patients suffering from primary adrenocortical insufficiency. MIF was infused at constant rates with stepwise increase... | Suppression of ACTH secretion by synthetic MSH-release inhibiting factor Pro-Leu-Gly-NH2 in Addison's disease. The regulation of release of MSH and ACTH seems to be closely related. The effect of Pro-Leu-Gly-NH2, the most active MSH-release inhibiting factor (MIF), was investigated on ACTH-hypersecretion in six patient... | [
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PMID:16827 | Isolation and partial characterization of plasma membranes from the livers of control and Streptococcus pneumoniae-infected rats. | Plasma membranes were isolated from the livers of control and Streptococcus pneumoniae-infected rats. This work, therefore, represents the first isolation of plasma membranes from infected actron microscopy and by the use of enzyme markers for microsomes (glucose-6-phosphatase), mitochondria (glutamate and malate dehy... | Isolation and partial characterization of plasma membranes from the livers of control and Streptococcus pneumoniae-infected rats. Plasma membranes were isolated from the livers of control and Streptococcus pneumoniae-infected rats. This work, therefore, represents the first isolation of plasma membranes from infected ... | [
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PMID:16828 | Gamma-irradiated chymotrypsin-like proteins. II. Connection between inactivation and structural changes. | The radiation yeilds of unfolding (Gconf) determined by the method of tryptophan fluorescence coincide with the radiation yields of proteolytic inactivation (Gin) for chymotrypsin-like (CT-like) enzymes on irradiation in air, both in solution and in the dry state with futher dissolution at pH7. It can be supposed that ... | Gamma-irradiated chymotrypsin-like proteins. II. Connection between inactivation and structural changes. The radiation yeilds of unfolding (Gconf) determined by the method of tryptophan fluorescence coincide with the radiation yields of proteolytic inactivation (Gin) for chymotrypsin-like (CT-like) enzymes on irradiati... | [
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PMID:16831 | Effect of changes in Pco2 on intraocular tension. | Elevated levels of inspired CO2 and blood Pco2 resulted in moderate elevation of IOT. A marked rapid decrease in IOT to a level less than baseline value was noted when inspired CO2 was suddenly decreased to ambient levels. Decrease in IOT was more pronounced than the decrease in Pco2 and increase in blood pH. Changes i... | Effect of changes in Pco2 on intraocular tension. Elevated levels of inspired CO2 and blood Pco2 resulted in moderate elevation of IOT. A marked rapid decrease in IOT to a level less than baseline value was noted when inspired CO2 was suddenly decreased to ambient levels. Decrease in IOT was more pronounced than the de... | [
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PMID:16834 | Loss of histochemically demonstrable catecholamines in the glomus cells of the carotid body after alpha-methyl-para-tyrosine treatment. | A statistically significant decrease in the intensity of catecholamine fluorescence of some carotid body glomus cells was observed after inhibition of the enzyme tyrosine hydroxylase by injection of 80 mg/kg alpha-methyl-paratyrosine. The intensity of the formaldehyde-induced fluorescence was measured in individual glo... | Loss of histochemically demonstrable catecholamines in the glomus cells of the carotid body after alpha-methyl-para-tyrosine treatment. A statistically significant decrease in the intensity of catecholamine fluorescence of some carotid body glomus cells was observed after inhibition of the enzyme tyrosine hydroxylase b... | [
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PMID:16832 | A new glucose 6-phosphate dehydrogenase variant (GDTrinacria) in two unrelated families of Sicilian ancestry. | A new G6PD variant in two unrelated families of Sicilian extraction is described. It is characterized by an enzyme activity amounting to 20% of normal, by a slow electrophoretic mobility, decreased Km values for both TPN and G6P, increased utilization of substrates analogues, thermolability and biphasic pH curve. It ha... | A new glucose 6-phosphate dehydrogenase variant (GDTrinacria) in two unrelated families of Sicilian ancestry. A new G6PD variant in two unrelated families of Sicilian extraction is described. It is characterized by an enzyme activity amounting to 20% of normal, by a slow electrophoretic mobility, decreased Km values fo... | [
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PMID:16833 | Endopolygalacturonase, an extracellular pectic enzyme of Rhizoctonia fragariae. | A pectolytic enzyme from culture filtrates of Rhizoctonia fragariae was purified approx. 29-fold. The enzyme exhibited maximal depolymerizing activity on Na-polypectate rather than pectin at pH 5.0 and was inhibited at different extent by divalent cations Mg++, Mn++, Ca++. The analysis by paper chromatography of the pr... | Endopolygalacturonase, an extracellular pectic enzyme of Rhizoctonia fragariae. A pectolytic enzyme from culture filtrates of Rhizoctonia fragariae was purified approx. 29-fold. The enzyme exhibited maximal depolymerizing activity on Na-polypectate rather than pectin at pH 5.0 and was inhibited at different extent by d... | [
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PMID:16859 | Volume characteristics of extra- and intraparenchymal segments of the canine pulmonary artery. | The volumes of the extraparenchymal segment (VpaEP) and intraparenchymal segment (VpaIP) of the pulmonary arterial tree were determined in intact anesthetized dogs during room air breathing and acute hypoxia. Total pulmonary arterial blood volume (Vpatotal) was calculated as the product of pulmonary blood flow and pulm... | Volume characteristics of extra- and intraparenchymal segments of the canine pulmonary artery. The volumes of the extraparenchymal segment (VpaEP) and intraparenchymal segment (VpaIP) of the pulmonary arterial tree were determined in intact anesthetized dogs during room air breathing and acute hypoxia. Total pulmonary ... | [
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PMID:16860 | Comparison of arm versus leg work in induction of acute episodes of asthma. | The severity of exercise-induced asthma varies with the type of exercise performed. To determine whether such variation could be attributed to the use of different muscle groups, we exercised arms separately from legs using a bicycle ergometer. First, arms were exercised to exhaustion, then legs were exercised at the s... | Comparison of arm versus leg work in induction of acute episodes of asthma. The severity of exercise-induced asthma varies with the type of exercise performed. To determine whether such variation could be attributed to the use of different muscle groups, we exercised arms separately from legs using a bicycle ergometer.... | [
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PMID:16861 | Ventilatory response in the fetal lamb following peripheral chemodenervation. | Carotid infusions of sodium cyanide solution and perfusions of hypoxemic or hypercapnic fetal blood were done before and after peripheral chemoreceptor denervation. Step changes in PaO2 ranged from -11 to -22 Torr; step changes in PaCO2 ranged from +17 to +42 Torr. The cyanide dose was 0.2 mg/kg per loop system. Contro... | Ventilatory response in the fetal lamb following peripheral chemodenervation. Carotid infusions of sodium cyanide solution and perfusions of hypoxemic or hypercapnic fetal blood were done before and after peripheral chemoreceptor denervation. Step changes in PaO2 ranged from -11 to -22 Torr; step changes in PaCO2 range... | [
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PMID:16862 | H+ transport from CNS in hypercapnia and regulation of CSF [HCO3-]. | CSF HCO3- increases more than plasma HCO3- in hypercapnia, and there are at least two sources for the CSF HCO3- increase--one derived from the simultaneous increase in plasma HCO3-, and the other, HCO3-formed from hydration of CO2 in the choroid plexus and glia and susceptible to inhibition by acetazolamide (J. Appl. P... | H+ transport from CNS in hypercapnia and regulation of CSF [HCO3-]. CSF HCO3- increases more than plasma HCO3- in hypercapnia, and there are at least two sources for the CSF HCO3- increase--one derived from the simultaneous increase in plasma HCO3-, and the other, HCO3-formed from hydration of CO2 in the choroid plexus... | [
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PMID:16863 | Hematology, viscosity, and respiratory functions of whole blood of the lesser mouse deer, Tragulus javanicus. | Blood samples from the lesser mouse deer were examined for hematology, viscosity, oxygen dissociation curve, and magnitude of the Bohr effect. Red corpuscle dimensions, determined under oil immersion with an ocular micrometer, averaged 2.2 micron while the cell counts averaged 53 million/micronl blood, and the packed c... | Hematology, viscosity, and respiratory functions of whole blood of the lesser mouse deer, Tragulus javanicus. Blood samples from the lesser mouse deer were examined for hematology, viscosity, oxygen dissociation curve, and magnitude of the Bohr effect. Red corpuscle dimensions, determined under oil immersion with an oc... | [
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PMID:16864 | Effects of potassium ions on the electrical and pH gradients across the membrane of Streptococcus lactis cells. | Bacteria transduce and conserve energy at the plasma membrane in the form of an electrochemical gradient of hydrogen ions (deltap). Energized cells of Streptococcus lactis accumulate K+ ions presumably in exchange for H+. We reasoned that if the movement of H+ is limited, then an increase in H+ efflux, effected by pota... | Effects of potassium ions on the electrical and pH gradients across the membrane of Streptococcus lactis cells. Bacteria transduce and conserve energy at the plasma membrane in the form of an electrochemical gradient of hydrogen ions (deltap). Energized cells of Streptococcus lactis accumulate K+ ions presumably in exc... | [
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PMID:16865 | Purification and properties of cis-toluene dihydrodiol dehydrogenase from Pseudomonas putida. | The purification of (+)-cis-1(S),2(R)-dihydroxy-3-methylcyclohexa-3,5-diene dehydrogenase from cells of Pseudomonas putida grown with toluene as the sole source of carbon and energy is reported. The molecular weight of the enzyme is 104,000 at pH 9.7. The enzyme is composed of four apparently identical subunits with mo... | Purification and properties of cis-toluene dihydrodiol dehydrogenase from Pseudomonas putida. The purification of (+)-cis-1(S),2(R)-dihydroxy-3-methylcyclohexa-3,5-diene dehydrogenase from cells of Pseudomonas putida grown with toluene as the sole source of carbon and energy is reported. The molecular weight of the enz... | [
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PMID:16866 | Purification and characterization of a neutral protease from Saccharomycopsis lipolytica. | Saccharomycopsis lipolytica 37-1 produced two inducible extracellular proteases, one under neutral or alkaline growth conditions and the second under acid conditions. Secretion of the neutral protease was repressed in the presence of glycerol or glucose, both of which supported rapid growth of the organism. Ammonium io... | Purification and characterization of a neutral protease from Saccharomycopsis lipolytica. Saccharomycopsis lipolytica 37-1 produced two inducible extracellular proteases, one under neutral or alkaline growth conditions and the second under acid conditions. Secretion of the neutral protease was repressed in the presence... | [
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PMID:16867 | 6-Phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) from slow-growing Rhizobia. | 6-Phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) (NAD+-6PGD) was detected in several slow-growing strains of rhizobia, and no activity involving NADP+ was found in the same extracts. By contrast, fast-growing strains of rhizobia had NADP+-6PGD activity; most of them also had NAD+-6PGD activity. NAD+-6PGD w... | 6-Phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) from slow-growing Rhizobia. 6-Phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) (NAD+-6PGD) was detected in several slow-growing strains of rhizobia, and no activity involving NADP+ was found in the same extracts. By contrast, fast-growing strains ... | [
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0.0066305664367973804,
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0.047552790492773056,
... |
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