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PMID:17097 | Equimolar addition of oligoribonucleotides with T4 RNA ligase. | T4 induced RNA ligase will join equimolar concentrations of two oligoribonucleotides, (Ap)3C and p(Up) 5, to form a single product, (Ap)3Cp(Up) 5, in high yield. The presence of the 3' phosphate on p(Up)5 prevents the oligomer from adding to itself. The pH optimum of the reaction is about 7.5, but less of the undesira... | Equimolar addition of oligoribonucleotides with T4 RNA ligase. T4 induced RNA ligase will join equimolar concentrations of two oligoribonucleotides, (Ap)3C and p(Up) 5, to form a single product, (Ap)3Cp(Up) 5, in high yield. The presence of the 3' phosphate on p(Up)5 prevents the oligomer from adding to itself. The pH... | [
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PMID:17098 | Circular dichroism study of polyriboxanthylic acid. | We report in the present paper the circular dichroism spectra of poly(X) at different pH and temperature values. The spectra are characteristic of three stable forms of poly(x) in the pH range of protonation of xanthosine. An electrostatic barrier is proposed to account for the hysteresis and metastability observed in ... | Circular dichroism study of polyriboxanthylic acid. We report in the present paper the circular dichroism spectra of poly(X) at different pH and temperature values. The spectra are characteristic of three stable forms of poly(x) in the pH range of protonation of xanthosine. An electrostatic barrier is proposed to accou... | [
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PMID:17099 | Polyamine induced aggregation of DNA. | Polyamine induced aggregation of various DNAs has been studied under conditions usually employed in many enzymatic assays where DNA is one of the substrates. Spermine was by far the most efficient polyamine in causing aggregation followed by spermidine and cadaverine. All double-stranded and naturally occurring single-... | Polyamine induced aggregation of DNA. Polyamine induced aggregation of various DNAs has been studied under conditions usually employed in many enzymatic assays where DNA is one of the substrates. Spermine was by far the most efficient polyamine in causing aggregation followed by spermidine and cadaverine. All double-st... | [
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PMID:17100 | Glycosyl conformational and inductive effects on the acid catalysed hydrolysis of purine nucleosides. | The log kobs vs. pH profiles were determined in the intermediate acidity region for the glycosyl hydrolysis of guanosine and its 8-amino, 8-monomethylamino, 8-dimethylamino and 8-bromo derivatives. The decreased rate of the 8-amino and enhanced rate of the 8-bromo compound compared to guanosine support an A type mechan... | Glycosyl conformational and inductive effects on the acid catalysed hydrolysis of purine nucleosides. The log kobs vs. pH profiles were determined in the intermediate acidity region for the glycosyl hydrolysis of guanosine and its 8-amino, 8-monomethylamino, 8-dimethylamino and 8-bromo derivatives. The decreased rate o... | [
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PMID:17101 | Isolation and characterization of N6-succinyladenosine from human urine. | From the urines of colon carcinoma patients and normal subjects we have isolated a nucleoside in which an amino group of aspartic acid is attached to the six position of purine ribonucleoside. The structure, N6-succinyladenosine, N-(9-B-D-ribofuranosylpurin-6-yl)aspartic acid was assigned on the basis of spectral data... | Isolation and characterization of N6-succinyladenosine from human urine. From the urines of colon carcinoma patients and normal subjects we have isolated a nucleoside in which an amino group of aspartic acid is attached to the six position of purine ribonucleoside. The structure, N6-succinyladenosine, N-(9-B-D-ribofur... | [
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PMID:17102 | Polynucleotides. XLVI. 1 Synthesis and properties of poly (2'-amino-2'-deoxyadenylic acid). | Poly (2'-amino-2'-deoxyadenylic acid) [poly (Aa)] was prepared from chemically synthesized 2'-amino-2'-deoxy-ADP by the catalysis of polynucleotide phosphorylase. Poly (Aa) showed a similar UV absorption spectra to poly (A), but quite different CD spectra at pH 7.0 and 5.7. At the former pH it showed a single negative... | Polynucleotides. XLVI. 1 Synthesis and properties of poly (2'-amino-2'-deoxyadenylic acid). Poly (2'-amino-2'-deoxyadenylic acid) [poly (Aa)] was prepared from chemically synthesized 2'-amino-2'-deoxy-ADP by the catalysis of polynucleotide phosphorylase. Poly (Aa) showed a similar UV absorption spectra to poly (A), bu... | [
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PMID:17103 | The ANA and research in nursing. | Research activities which always have been part of the American Nurses' Association program have increased greatly in the last 15 years. Among ANA's significant contributions to nursing research have been sponsoring nine nursing research conferences (1965-1973) and establishing the ANA Commission on Nursing Research an... | The ANA and research in nursing. Research activities which always have been part of the American Nurses' Association program have increased greatly in the last 15 years. Among ANA's significant contributions to nursing research have been sponsoring nine nursing research conferences (1965-1973) and establishing the ANA ... | [
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PMID:17108 | [Study of the conditions maintaining the synthesis of alpha-amylase by Bacillus species]. | The effect of temperature and different carbon sources on the growth of Bacillus species and the synthesis of alpha-amylase was studied. The temperature of 40 degrees proved to be optimal for those processes. Starch was found to be the best carbon source. The maximum accumulation of the enzyme was seen by the 40th hour... | [Study of the conditions maintaining the synthesis of alpha-amylase by Bacillus species]. The effect of temperature and different carbon sources on the growth of Bacillus species and the synthesis of alpha-amylase was studied. The temperature of 40 degrees proved to be optimal for those processes. Starch was found to b... | [
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PMID:17109 | [Phospholipase of Bacillus cereus]. | Phospholipase activity of 10 strains of Bacillus cereus was studied. The most active strain of Bac. cereus--phospholipase producer was selected. A cultivation mixture of Bac. cereus optimal for the phospholipase synthesis was found to include peptone, yeast extract, glucose, NaCl and Na2HPO4. Proper conditions for the ... | [Phospholipase of Bacillus cereus]. Phospholipase activity of 10 strains of Bacillus cereus was studied. The most active strain of Bac. cereus--phospholipase producer was selected. A cultivation mixture of Bac. cereus optimal for the phospholipase synthesis was found to include peptone, yeast extract, glucose, NaCl and... | [
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PMID:17110 | [Comparative study of the properties of lipase of microbial origin]. | A comparative study of properties of lipases of microbial origin has shown that the pH optimum of the enzymes from Geotrichum asteroides and Penicillium sp. is at pH 7.5 and 5.0, respectively. Lipase from Geotrichum asteroides appears more resistant to high temperatures and pH changes than the enzyme from Penicillium s... | [Comparative study of the properties of lipase of microbial origin]. A comparative study of properties of lipases of microbial origin has shown that the pH optimum of the enzymes from Geotrichum asteroides and Penicillium sp. is at pH 7.5 and 5.0, respectively. Lipase from Geotrichum asteroides appears more resistant t... | [
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PMID:17111 | [Method of determination of the activity of glycerol dehydrogenase in the submerged culture of Acetobacter suboxydans]. | The paper presents a method for assaying activity of glycerol dehydrogenase activity in the submerged culture of Acetobacter suboxydans. The effect of substrate concentration, content of the submerged culture in the reaction mixture and pH value on the rate of enzymic oxidation of glycerol to dihygrooxyacetone by A. su... | [Method of determination of the activity of glycerol dehydrogenase in the submerged culture of Acetobacter suboxydans]. The paper presents a method for assaying activity of glycerol dehydrogenase activity in the submerged culture of Acetobacter suboxydans. The effect of substrate concentration, content of the submerged... | [
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PMID:17115 | A DNA nicking-closing enzyme encapsidated in vaccinia virus: partial purification and properties. | Vaccinia virus cores contain an activity which is able to relax both left-and right-handed superhelical DNA. This virus-specific nicking closing enzyme has been highly purified and differs from the corresponding host enzyme in salt optimum, in sedimentation coefficient, and in polypeptide composition as determined on s... | A DNA nicking-closing enzyme encapsidated in vaccinia virus: partial purification and properties. Vaccinia virus cores contain an activity which is able to relax both left-and right-handed superhelical DNA. This virus-specific nicking closing enzyme has been highly purified and differs from the corresponding host enzym... | [
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PMID:17113 | [Desugarization of egg white by microorganisms]. | Glucose was eliminated from egg whites, using microorganisms, to prevent melanoidin formation which may damage the product. Desugarization was achieved by means of Acetobacter xylinum, Streptococcus lactis, Propionibacterium shermanii, Pr. petersonii and propionicacid cocci. Optimal conditions of desugarization were fo... | [Desugarization of egg white by microorganisms]. Glucose was eliminated from egg whites, using microorganisms, to prevent melanoidin formation which may damage the product. Desugarization was achieved by means of Acetobacter xylinum, Streptococcus lactis, Propionibacterium shermanii, Pr. petersonii and propionicacid co... | [
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PMID:17116 | H+/ATP ratio during ATP hydrolysis by mitochondria: modification of the chemiosmotic theory. | The stoichiometry of H+ ejection by mitochondria during hydrolysis of a small pulse of ATP (the H+/ATP ratio) has been reexamined in the light of our recent observation that the stoichiometry of H+ ejection during mitochondrial electron transport (the H+/site ratio) was previously underestimated. We show that earlier e... | H+/ATP ratio during ATP hydrolysis by mitochondria: modification of the chemiosmotic theory. The stoichiometry of H+ ejection by mitochondria during hydrolysis of a small pulse of ATP (the H+/ATP ratio) has been reexamined in the light of our recent observation that the stoichiometry of H+ ejection during mitochondrial... | [
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PMID:17117 | 9S binding protein for androgens and progesterone. | A steroid binding protein fraction with a sedimentation coefficient of approximately 9 S (molecular weight approximately equal to 200,000) has been identified in 105,000 X g supernatants of several androgen-responsive organs. Highest concentrations were found in epididymis and testis, but small amounts were detected in... | 9S binding protein for androgens and progesterone. A steroid binding protein fraction with a sedimentation coefficient of approximately 9 S (molecular weight approximately equal to 200,000) has been identified in 105,000 X g supernatants of several androgen-responsive organs. Highest concentrations were found in epidid... | [
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PMID:17114 | [Properties of a preparation of lytic enzymes from a culture of Bacillus subtilis]. | The effect of pH, temperature, various salts and other compounds on the activity of the preparation of lytic enzymes from the culture of Bacillus subtilis (lyzosubtilin) was investigated. The preparation was shown to be active in neutral solutions of low ionic strength at 30-50 degrees C. The salts of magnesium, mangan... | [Properties of a preparation of lytic enzymes from a culture of Bacillus subtilis]. The effect of pH, temperature, various salts and other compounds on the activity of the preparation of lytic enzymes from the culture of Bacillus subtilis (lyzosubtilin) was investigated. The preparation was shown to be active in neutra... | [
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PMID:17118 | Solid-like character of virus solutions. | The solid-like behavior of turnip yellow mosaic virus solutions following the extrusion of viral RNA in alkali was observed with a torsion-fiber balance developed for the purpose. This method provided a direct measurement of the yield stresses required to break or liquefy these solutions. The yield stresses were found ... | Solid-like character of virus solutions. The solid-like behavior of turnip yellow mosaic virus solutions following the extrusion of viral RNA in alkali was observed with a torsion-fiber balance developed for the purpose. This method provided a direct measurement of the yield stresses required to break or liquefy these ... | [
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PMID:17119 | Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells. | A novel variant of the S49 mouse lymphoma has been selected from wild-type cells by growth in medium containing the beta-adrenergic agonist terbutaline and inhibitors of cyclic nucleotide phosphodiesterase. In contrast to the situation in the wild-type clone, synthesis of adenosine 3':5'-monophosphate (cyclic AMP) is n... | Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells. A novel variant of the S49 mouse lymphoma has been selected from wild-type cells by growth in medium containing the beta-adrenergic agonist terbutaline and inhibitors of cyclic nucleotide phosphodiesterase. In... | [
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PMID:17120 | A defined minimal medium for axenic strains of Dictyostelium discoideum. | A defined, minimal medium for the cellular slime mold Dictyostelium discoideum is reported. | A defined minimal medium for axenic strains of Dictyostelium discoideum. A defined, minimal medium for the cellular slime mold Dictyostelium discoideum is reported. | [
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PMID:17133 | [Migrating and recurrent superficial phlebitis and Takayasu's disease (apropos of a case)]. | This case of recurrent migratory superficial phlebitis is reported because of the highly unusual nature of the lesion observed. The picture was dominated by periphlebitis with inflammatory granuloma, giant cells and elastophagia. When the condition had been present for sixteen months, an aortic arch syndrome developed ... | [Migrating and recurrent superficial phlebitis and Takayasu's disease (apropos of a case)]. This case of recurrent migratory superficial phlebitis is reported because of the highly unusual nature of the lesion observed. The picture was dominated by periphlebitis with inflammatory granuloma, giant cells and elastophagia... | [
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PMID:17140 | Cryptorchism. | Our results from 121 patients as well as data from the literature prove that fertility rates after treatment of uni- or bilateral cryptorchism remain unsatisfactory. There is no statistically significant difference in fertility between a group of patients treated with human-chorionic-gonadotrophin and another group tre... | Cryptorchism. Our results from 121 patients as well as data from the literature prove that fertility rates after treatment of uni- or bilateral cryptorchism remain unsatisfactory. There is no statistically significant difference in fertility between a group of patients treated with human-chorionic-gonadotrophin and ano... | [
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PMID:17141 | Long-term results of undescended testicle operative treatment. | Men affected with unilateral and bilateral undescended testicles have been examined 10 to 20 years after orchidopexy. The examined patients were divided into groups of individuals operated before and after the 8th year of life. Fertility, structure of the genitals, somatotype, psychosexual behavior, and plasma testoste... | Long-term results of undescended testicle operative treatment. Men affected with unilateral and bilateral undescended testicles have been examined 10 to 20 years after orchidopexy. The examined patients were divided into groups of individuals operated before and after the 8th year of life. Fertility, structure of the g... | [
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PMID:17142 | The vasoconstrictive effect of dopamine in the isolated, perfused rat kidney after catecholamine depletion. | In the isolated, perfused kidney of untreated and catcholamine-depleted rats (by 6-hydroxydopamine and reserpine), dopamine (DA) caused a dose-dependent increase in vascular resistance which could be prevented by prior blockade of the alpha-adreno-receptors. The DA-induced vasoconstriction thus appears to be due to a d... | The vasoconstrictive effect of dopamine in the isolated, perfused rat kidney after catecholamine depletion. In the isolated, perfused kidney of untreated and catcholamine-depleted rats (by 6-hydroxydopamine and reserpine), dopamine (DA) caused a dose-dependent increase in vascular resistance which could be prevented by... | [
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PMID:17144 | Role of Pco2 oscillations and chemoreceptors in ventilatory response to inhaled and infused CO2. | We have previously shown in the anaesthetized rabbit that the ventilatory response to an increase in Paco2 is greater if that increase is produced by intravenous infusion of hypercapnic blood than by inhalation of CO2 (Linton et al., 1976). The present set of experiments was designed to investigate the reason for this.... | Role of Pco2 oscillations and chemoreceptors in ventilatory response to inhaled and infused CO2. We have previously shown in the anaesthetized rabbit that the ventilatory response to an increase in Paco2 is greater if that increase is produced by intravenous infusion of hypercapnic blood than by inhalation of CO2 (Lint... | [
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PMID:17152 | Microflora in the healthy gingival sulcus in man. | The roll tube culture technique was utilized to examine quantitatively and qualitatively the predominant cultivable microflora inhabiting the clinically healthy gingival sulcus. Seven periodontists aged 32-54 years were included in the study. From a total of 350 isolates, 85 (24.3%) were obligate anaerobes, 53 (15.0%) ... | Microflora in the healthy gingival sulcus in man. The roll tube culture technique was utilized to examine quantitatively and qualitatively the predominant cultivable microflora inhabiting the clinically healthy gingival sulcus. Seven periodontists aged 32-54 years were included in the study. From a total of 350 isolate... | [
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PMID:17153 | Plasma secretin concentration in anaesthetized pigs after intraduodenal glucose, fat, aminoacids, or meals with various pH. | The concentration of immunoreactive secretin in portal blood and the secretion from the exocrine pancreas were measured during intraduodenal infusion of isotonic or hypertonic saline, isotonic or hypertonic glucose, aminoacids, fat emulsion, or 0.1 mol X 1(-1) hydrochloric acid in 7 anaesthetized pigs. None of these su... | Plasma secretin concentration in anaesthetized pigs after intraduodenal glucose, fat, aminoacids, or meals with various pH. The concentration of immunoreactive secretin in portal blood and the secretion from the exocrine pancreas were measured during intraduodenal infusion of isotonic or hypertonic saline, isotonic or ... | [
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PMID:17156 | [Bacterial endocarditis: clinical and bacteriological aspects and prognostic factors]. | The microbiological, clinical and therapeutic aspects of all (71) cases of bacterial endocarditis admitted to the Hôpital cantonal, Geneva, between August 1970 and October 1974 were reviewed: there was a definite trend towards higher prevalence of acute cases compared to subacute cases. The pathogenic role of S. epider... | [Bacterial endocarditis: clinical and bacteriological aspects and prognostic factors]. The microbiological, clinical and therapeutic aspects of all (71) cases of bacterial endocarditis admitted to the Hôpital cantonal, Geneva, between August 1970 and October 1974 were reviewed: there was a definite trend towards higher... | [
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PMID:17157 | [Peptic ulcer: new aspects of conservative therapy]. | In spite of the large number of preparations, medical therapy of peptic ulcer disease has long been unsatisfactory. Antacids, anticholinergics and diet neither accelerate healing of ulcers nor prevent recurrences. Carbenoxolone affects only gastric ulcers, while some medications exhibit substantial side effects. Cimeti... | [Peptic ulcer: new aspects of conservative therapy]. In spite of the large number of preparations, medical therapy of peptic ulcer disease has long been unsatisfactory. Antacids, anticholinergics and diet neither accelerate healing of ulcers nor prevent recurrences. Carbenoxolone affects only gastric ulcers, while some... | [
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PMID:17158 | [Gastro-esophageal reflux disease. A review of pathogenesis, diagnosis and therapy]. | Gastro-esophageal reflux disease is caused by peptic damage from gastric contents to the distal esophagus. The principal cause of reflux is a decrease in pressure of the lower esophageal sphincter, which normally separates the esophagus from the stomach. Various hormonal, pharmacological or toxic agents are capable of ... | [Gastro-esophageal reflux disease. A review of pathogenesis, diagnosis and therapy]. Gastro-esophageal reflux disease is caused by peptic damage from gastric contents to the distal esophagus. The principal cause of reflux is a decrease in pressure of the lower esophageal sphincter, which normally separates the esophagu... | [
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PMID:17159 | Localization of nigral dopamine-sensitive adenylate cyclase on neurons originating from the corpus striatum. | Nigral basal adenylate cyclase and dopamine-sensitive adenylate cyclase, glutamate decarboxylase, choline acetyltransferase, and tyrosine hydroxylase activities were measured in rats with hemitransections at various levels or with electrolytic lesions of the medial forebrain bundle or the crus cerebri. The loss of nigr... | Localization of nigral dopamine-sensitive adenylate cyclase on neurons originating from the corpus striatum. Nigral basal adenylate cyclase and dopamine-sensitive adenylate cyclase, glutamate decarboxylase, choline acetyltransferase, and tyrosine hydroxylase activities were measured in rats with hemitransections at var... | [
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PMID:17160 | Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2+. | The addition of Sr2+ or Ba2+ to the solution bathing the frog neuromuscular junction leads to an increased release of transmitter by each nerve impulse during and following repetitive stimulation. The mechanisms by which Sr2+ and Ba2+ increase release are not the same. Each ion appears to act selectively on a different... | Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2+. The addition of Sr2+ or Ba2+ to the solution bathing the frog neuromuscular junction leads to an increased release of transmitter by each nerve impulse during and following repetitive stimulation. The mechanisms by which Sr2... | [
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PMID:17161 | [Periarteritis nodosa and Australia antigen. Comparative study apropos of 25 cases]. | The authors compared two series of 27 cases of périateritis over a period of 5 years. The determined the frequency of the nodosa HBs+ (series B) and HBs-- (series A) collected clinical and laboratory signs in both series. There resulted that apart from the hepatic signs constant in series B and absent in series A, the ... | [Periarteritis nodosa and Australia antigen. Comparative study apropos of 25 cases]. The authors compared two series of 27 cases of périateritis over a period of 5 years. The determined the frequency of the nodosa HBs+ (series B) and HBs-- (series A) collected clinical and laboratory signs in both series. There resulte... | [
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PMID:17162 | [Beta blockaders and general pathology]. | The authors review the literature on the undesirable side effects of beta blockaders (excluding the cardiovascular system) and report the new therapeutic propects in psychiatry and in various metabolic disorders. The necessity of sufficient follow up made us choose propanolol as reference product without neglecting ace... | [Beta blockaders and general pathology]. The authors review the literature on the undesirable side effects of beta blockaders (excluding the cardiovascular system) and report the new therapeutic propects in psychiatry and in various metabolic disorders. The necessity of sufficient follow up made us choose propanolol as... | [
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PMID:17164 | Expression of differentiated functions in hepatoma cell hybrids: IX extinction and reexpression of liver-specific enzymes in rat hepatoma-Chinese hamster fibroblast hybrids. | Most of the hybrid clones derived from a cross of Chinese hamster fibroblasts (DON) with rat hepatoma cells (Faza 967) showed preferential loss of rat chromosomes. Two of the hybrid clones retained the rat chromosomes, and both showed extinction of 4 liver-specific enzymes: aldolase B, liver alcohol dehydrogenase, and ... | Expression of differentiated functions in hepatoma cell hybrids: IX extinction and reexpression of liver-specific enzymes in rat hepatoma-Chinese hamster fibroblast hybrids. Most of the hybrid clones derived from a cross of Chinese hamster fibroblasts (DON) with rat hepatoma cells (Faza 967) showed preferential loss of... | [
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PMID:17165 | Extinction of liver-specific functions in hybrids between differentiated and dedifferentiated rat hepatoma cells. | A cross has been performed between dedifferentiated rat hepatoma cells and the differentiated cells from which they were derived. 10 hybrid clones, containing the complete chromosome sets of both parents, show extinction of 4 liver-specific enzymes: tyrosine aminotransferase (E.C. 2.6.1.5), alanine aminotransferase (E.... | Extinction of liver-specific functions in hybrids between differentiated and dedifferentiated rat hepatoma cells. A cross has been performed between dedifferentiated rat hepatoma cells and the differentiated cells from which they were derived. 10 hybrid clones, containing the complete chromosome sets of both parents, s... | [
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PMID:17163 | In vitro inhibition of growth of neisseria gonorrhoeae by genital microorganisms. | The ability of microorganisms present in titers of over 10(5)/ml in the vaginal or cervical secretions to inhibit growth of N. gonorrhoeae in vitro was tested. Study of a strain of N. gonorrhoeae against 77 microorganisms demonstrated that most strans of S. epidermidis, S. aureus and the one "Gaffkya anaerobia" interfe... | In vitro inhibition of growth of neisseria gonorrhoeae by genital microorganisms. The ability of microorganisms present in titers of over 10(5)/ml in the vaginal or cervical secretions to inhibit growth of N. gonorrhoeae in vitro was tested. Study of a strain of N. gonorrhoeae against 77 microorganisms demonstrated tha... | [
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PMID:17180 | Reduction of fatal graft-versus-host disease by 3H-thymidine suicide of donor cells cultured with host cells. | The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity add... | Reduction of fatal graft-versus-host disease by 3H-thymidine suicide of donor cells cultured with host cells. The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro ... | [
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PMID:17181 | In vivo and in vitro effects of acute graft-versus-host serum in the rat. | Pooled serum from 6- to 8-week-old female Lewis x Brown Norwegian F1 hybrid (LBNF1) rats undergoing acute local graft-versus-host (GVH) reactions was found to have the ability, when compared with normal F1 serum, to increase node weight in a popliteal lymph node weight gain assay in syngeneic animals. Suspension of don... | In vivo and in vitro effects of acute graft-versus-host serum in the rat. Pooled serum from 6- to 8-week-old female Lewis x Brown Norwegian F1 hybrid (LBNF1) rats undergoing acute local graft-versus-host (GVH) reactions was found to have the ability, when compared with normal F1 serum, to increase node weight in a popl... | [
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PMID:17182 | Generation of suppressor cells in mice immunized with M locus-incompatible lymphocytes. | Alloimmunization of mice with M locus-incompatible lymphocytes resulted in the generation of suppressor cells in the immunized host. Lymph node cells from such alloimmunized mice suppressed the in vitro cytotoxic response of normal cells to H-2 alloantigens. The suppression generated was greater than could be accounted... | Generation of suppressor cells in mice immunized with M locus-incompatible lymphocytes. Alloimmunization of mice with M locus-incompatible lymphocytes resulted in the generation of suppressor cells in the immunized host. Lymph node cells from such alloimmunized mice suppressed the in vitro cytotoxic response of normal ... | [
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PMID:17183 | HLA-D compatibility between parent and child: increased occurrence in severe combined immunodeficiency and other hematopoietic diseases. | Weak or weak intermediate reactions in one-way mixed lymphocyte culture (MLC) were seen between a patient and at least one parent in the families of 6 of 15 patients with severe combined immunodeficiency disease, 3 of 4 patients with Fanconi's anemia, and 3 of 7 patients with congenital neutropenia (CN). In control fam... | HLA-D compatibility between parent and child: increased occurrence in severe combined immunodeficiency and other hematopoietic diseases. Weak or weak intermediate reactions in one-way mixed lymphocyte culture (MLC) were seen between a patient and at least one parent in the families of 6 of 15 patients with severe combi... | [
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PMID:17185 | A comparison of immune responses against AG-B and non-AG-B antigens, presented alone or together. | By exploiting congenic rat strains (HO.B2 and PVG/c) cell-mediated immune responses against Ag-B antigens alone were measured and compared with responses against (1) non-Ag-B antigens and (2) Ag-B and non-Ag-B antigens in combination. It was confirmed that multiple non-Ag-B antigens provoke prompt first-set skin graft ... | A comparison of immune responses against AG-B and non-AG-B antigens, presented alone or together. By exploiting congenic rat strains (HO.B2 and PVG/c) cell-mediated immune responses against Ag-B antigens alone were measured and compared with responses against (1) non-Ag-B antigens and (2) Ag-B and non-Ag-B antigens in ... | [
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PMID:17186 | The graft-versus-host reactivity in AG-B/MLR disparate strains of rats. | Inbred strains of rats can currently be classified into eight Ag-B groups. Within an Ag-B group, individual strains generally share identity both the Ag-B histocompatibility antigens and mixed lymphocyte responses. In this report we present data from three strains which are Ag-B and mixed lymphocyte reaction (MLR) disp... | The graft-versus-host reactivity in AG-B/MLR disparate strains of rats. Inbred strains of rats can currently be classified into eight Ag-B groups. Within an Ag-B group, individual strains generally share identity both the Ag-B histocompatibility antigens and mixed lymphocyte responses. In this report we present data fr... | [
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PMID:17188 | Bone marrow transplantation. | Improvements in the results of bone marrow transplantation for the treatment of SCID may be expected by employing purified stem-cell concentrates for patients who do not have a compatible sibling available. Refinements in the purification technique and its monitoring are required, however. For the same category of pati... | Bone marrow transplantation. Improvements in the results of bone marrow transplantation for the treatment of SCID may be expected by employing purified stem-cell concentrates for patients who do not have a compatible sibling available. Refinements in the purification technique and its monitoring are required, however. ... | [
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PMID:17192 | Specific absorbed antithymocyte globulin for incubation treatment in human marrow transplantation. | The experimental data show that absorption of ATG with liver-kidney homogenate and CLL and LCL cells stepwise removed the hemopoietic toxicity, whereas the specific activity against T lymphocytes remained. Although the mode of action of absorbed ATG could not be tested in the first clinical case, the successful experim... | Specific absorbed antithymocyte globulin for incubation treatment in human marrow transplantation. The experimental data show that absorption of ATG with liver-kidney homogenate and CLL and LCL cells stepwise removed the hemopoietic toxicity, whereas the specific activity against T lymphocytes remained. Although the mo... | [
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PMID:17198 | Other mammalian histocompatibility systems. Skin graft rejection and graft-versus-host reaction across I-subregion differences: are there many more than three H loci within the H-2 complex? | The data confirm an earlier finding by Klein et al. that the I region harbors a strong histocompatibility locus, which by exclusion might be assigned to the IA subregion. In addition, it appears that intercalated between the IA subregion and S region there is a minor H locus since (DBA/2 X 4R)F1 rejects skin of 2R in a... | Other mammalian histocompatibility systems. Skin graft rejection and graft-versus-host reaction across I-subregion differences: are there many more than three H loci within the H-2 complex? The data confirm an earlier finding by Klein et al. that the I region harbors a strong histocompatibility locus, which by exclusio... | [
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PMID:17213 | Nuclear and cytoplasmic RNase-activity in regenerating mouse liver. | Nuclear and cytoplasmic RNase activities at pH 5.0 and 7.6 were analyzed in regenerating mouse liver at 6, 12, 24, 48, and 72 h after partial hepatectomy. Two different nucleus-isolation methods were used, one in a EDTA-spermidine medium free from divalent cations, and one in a sucrose medium containing these ions. Dur... | Nuclear and cytoplasmic RNase-activity in regenerating mouse liver. Nuclear and cytoplasmic RNase activities at pH 5.0 and 7.6 were analyzed in regenerating mouse liver at 6, 12, 24, 48, and 72 h after partial hepatectomy. Two different nucleus-isolation methods were used, one in a EDTA-spermidine medium free from diva... | [
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PMID:17208 | [Characteristics of the serum proteins of cancer patients in an acid medium]. | Under condition of nitric acid titration of aqueous and hydrochloride solutions of sera from patients with cancer certain serum proteins become insoluble at higher values of pH as compared to the other proteins of sera. The latter lose solubility at the pH values corresponding to transition to the insoluble state of se... | [Characteristics of the serum proteins of cancer patients in an acid medium]. Under condition of nitric acid titration of aqueous and hydrochloride solutions of sera from patients with cancer certain serum proteins become insoluble at higher values of pH as compared to the other proteins of sera. The latter lose solubi... | [
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PMID:17209 | [ATPase activity and fluorescence of myometrial actomyosin in experimental uterine inertia]. | A comparative study was performed for actomyosin complexes of the female rabbit myometrium in the state of labour (actomyosin of the control) and secondary uterine inertia (actomyosin of the model). Under the secondary uterine inertia the activity of actomyosin Ca2+- and Mg2+-ATPase decreases. When pH of the medium cha... | [ATPase activity and fluorescence of myometrial actomyosin in experimental uterine inertia]. A comparative study was performed for actomyosin complexes of the female rabbit myometrium in the state of labour (actomyosin of the control) and secondary uterine inertia (actomyosin of the model). Under the secondary uterine ... | [
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PMID:17219 | [Intracellular nucleodepolymerase of bacteria, representatives of the Proteus and Providencia groups. Its isolation and properties]. | High activity of enzymes, splitting native, denaturated DNA, deoxyribooligonucleotides and RNA, was observed in cell free extracts of bacteria--representatives of 5 strains of Proteus-Providencia. Some properties of nucleases were studied in cell free extracts. In the bacteria studied DNAases were thermolabile proteins... | [Intracellular nucleodepolymerase of bacteria, representatives of the Proteus and Providencia groups. Its isolation and properties]. High activity of enzymes, splitting native, denaturated DNA, deoxyribooligonucleotides and RNA, was observed in cell free extracts of bacteria--representatives of 5 strains of Proteus-Pro... | [
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PMID:17220 | [Role of divalent cations in the structural organization of the peroxisomal membrane]. | Factors, which affected the stability of peroxisomal membrane in vitro, were investigated. The decrease in the activity of catalase at neutral and alkaline pH was prevented by addition of Ca2+, Mg2+ and Ba2+; at the same time EDTA, EGTA and o-phenantroline decreased the stability of peroxisomes. All the effects were te... | [Role of divalent cations in the structural organization of the peroxisomal membrane]. Factors, which affected the stability of peroxisomal membrane in vitro, were investigated. The decrease in the activity of catalase at neutral and alkaline pH was prevented by addition of Ca2+, Mg2+ and Ba2+; at the same time EDTA, E... | [
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PMID:17222 | [Labilization of lysosomal and peroxisomal membranes in the kidneys preserved by transrenal gas perfusion]. | The total, free and unprecipitated activity of lysosomal (acid DNAase, acid RNAase, acid phosphate, acid beta-galactosidase) and peroxisomal (catalase, oxidase of D-amino acids) enzymes were studied in dog kidney cortex during storage of the tissues in solution of rheopolyglucin and under conservation of the kidney tis... | [Labilization of lysosomal and peroxisomal membranes in the kidneys preserved by transrenal gas perfusion]. The total, free and unprecipitated activity of lysosomal (acid DNAase, acid RNAase, acid phosphate, acid beta-galactosidase) and peroxisomal (catalase, oxidase of D-amino acids) enzymes were studied in dog kidney... | [
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PMID:17223 | [Role of salivary ribonuclease in pathogenesis of periodontosis]. | In patients with periodontal disease a distinct increase in secretion of salivary acidic and alkaline RNAases was found. The RNAases activity in mixed saliva correlated with the intensity of degradation of periodontal tissues during loss of alveolar layer in aged Wistar rats and the spontaneous periodontal disease in c... | [Role of salivary ribonuclease in pathogenesis of periodontosis]. In patients with periodontal disease a distinct increase in secretion of salivary acidic and alkaline RNAases was found. The RNAases activity in mixed saliva correlated with the intensity of degradation of periodontal tissues during loss of alveolar laye... | [
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PMID:17227 | Subtypes of depression--diagnosis and medical management. | Depression is both a common and a greatly undertreated illness in the United States today. The focus of this review is a definition of the characteristics of four subtypes of depression which appear to be differentially sensitive to four different classes of medications. The tricyclic antidepressants should be used for... | Subtypes of depression--diagnosis and medical management. Depression is both a common and a greatly undertreated illness in the United States today. The focus of this review is a definition of the characteristics of four subtypes of depression which appear to be differentially sensitive to four different classes of med... | [
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PMID:17221 | [New variant of glucose-6-phosphate dehydrogenase (G-6-PD "Kaluga") from erythrocytes of a patient with chronic nonspherocytic hemolytic anemia]. | Properties of a new form of glucose-6-phosphate dehydrogenase (G6PD) from erythrocytes, called "Kaluga", are described. The enzyme was isolated from erythrocytes of a patient with chronic non-spherocytic hemolytic anemia; in the blood cells 20% of the G6PD activity was maintained as compared with normal state. The part... | [New variant of glucose-6-phosphate dehydrogenase (G-6-PD "Kaluga") from erythrocytes of a patient with chronic nonspherocytic hemolytic anemia]. Properties of a new form of glucose-6-phosphate dehydrogenase (G6PD) from erythrocytes, called "Kaluga", are described. The enzyme was isolated from erythrocytes of a patient... | [
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PMID:17229 | Drugs for peptic ulcer. | Conservative management of peptic ulcer relies on the use of drugs as an adjuvant to the time-honored measures of avoiding stress, reducing gastric secretion, and regulating the diet. Alkalies neutralize acid and anticholinergic drugs partly inhibit secretion.. Both are widely used but are often inadequate to control s... | Drugs for peptic ulcer. Conservative management of peptic ulcer relies on the use of drugs as an adjuvant to the time-honored measures of avoiding stress, reducing gastric secretion, and regulating the diet. Alkalies neutralize acid and anticholinergic drugs partly inhibit secretion.. Both are widely used but are often... | [
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PMID:17225 | [Degradation of polysomes of skeletal muscles of rats during preservation in solutions with different pH]. | Alterations in properties of RNP-particles from rat sceletal muscles on storage of the preparations in buffer solutions at various pH were analyzed by means of centrifugation in sucrose gradients. Within 3 days of incubation at 20 the distribution of RNP-particles in the sucrose gradient was changed relatively slightly... | [Degradation of polysomes of skeletal muscles of rats during preservation in solutions with different pH]. Alterations in properties of RNP-particles from rat sceletal muscles on storage of the preparations in buffer solutions at various pH were analyzed by means of centrifugation in sucrose gradients. Within 3 days of... | [
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PMID:17224 | [Inhibition of bacterial agmatinase by substrate analogs]. | Activity of agmatinase (EC 3.5.3.11) from Proteus vulgaris was studied in presence of guanidine derivatives of agmatine as substrates. The guanidine derivatives, containing carboxyl group, did not interact with the enzyme. An inhibitory effect developed if the carboxyl group was esterified. For exhibition of the effect... | [Inhibition of bacterial agmatinase by substrate analogs]. Activity of agmatinase (EC 3.5.3.11) from Proteus vulgaris was studied in presence of guanidine derivatives of agmatine as substrates. The guanidine derivatives, containing carboxyl group, did not interact with the enzyme. An inhibitory effect developed if the ... | [
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PMID:17230 | Progress in the treatment of acute gastroduodenal mucosal lesions (AGML). | This article presents an analysis of acute gastroduodenal mucosal lesions (AGML) based on a review of current literature and the personal experience of the authors. The pathology of AGML involes two distinct types of lesions, namely, superficial erosions confined to the acid-secreting gastric mucosa and presenting as e... | Progress in the treatment of acute gastroduodenal mucosal lesions (AGML). This article presents an analysis of acute gastroduodenal mucosal lesions (AGML) based on a review of current literature and the personal experience of the authors. The pathology of AGML involes two distinct types of lesions, namely, superficial ... | [
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PMID:17233 | The effect of glucagon on pancreatic secretion and plasma secretin in dogs. | The inhibitory effect of glucagon on pancreatic exocrine secretion induced by endogenously released secretin was studied in 4 dogs with chronic pancreatic fistulas and open gastric fistulas. After a constant level of pancreatic secretion was established by intraduodenal hydrochloric acid perfusion (9 mEq/hr), glucagon ... | The effect of glucagon on pancreatic secretion and plasma secretin in dogs. The inhibitory effect of glucagon on pancreatic exocrine secretion induced by endogenously released secretin was studied in 4 dogs with chronic pancreatic fistulas and open gastric fistulas. After a constant level of pancreatic secretion was es... | [
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PMID:17249 | Prevalence of drugs among drivers arrested for drinking and driving in Finland. | A combined thin layer and gas chromatography system was developed for qualitative and quantitative analysis of drugs in biological samples after extraction with heptane-isoamyl alcohol. Both acidic and basic extraction procedures were used. Special methods were used for the extraction and detection of salicylates, ison... | Prevalence of drugs among drivers arrested for drinking and driving in Finland. A combined thin layer and gas chromatography system was developed for qualitative and quantitative analysis of drugs in biological samples after extraction with heptane-isoamyl alcohol. Both acidic and basic extraction procedures were used.... | [
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PMID:17250 | [Relationship between the characteristics of the acid stimulus and the impulse activity of medulla oblongata neurons in Cyprinus carpio carp]. | In experiments on immobilized carps, by means of extracellular recordings, studies have been made of the neuronal activity of the facial lobe in the medulla evoked by stimulation of skin chemoreceptors of the mouth opening with hydrochloric and cytric acids. Responses of the neurons to these stimuli exhibit both simila... | [Relationship between the characteristics of the acid stimulus and the impulse activity of medulla oblongata neurons in Cyprinus carpio carp]. In experiments on immobilized carps, by means of extracellular recordings, studies have been made of the neuronal activity of the facial lobe in the medulla evoked by stimulatio... | [
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PMID:17252 | [Isolation and several properties of the glyceraldehyde-3-phosphate dehydrogenase from the muscles of the lamprey Lampetra fluviatillis]. | Procedure for isolation of electrophoretically homogeneous, crystalline glyceraldehyde-3-phosphate dehydrogenase from lamprey muscles is described. Amino acid composition of the enzyme was investigated and compared with that of the same dehydrogenase from other sources. With respect to its secondary structure and kinet... | [Isolation and several properties of the glyceraldehyde-3-phosphate dehydrogenase from the muscles of the lamprey Lampetra fluviatillis]. Procedure for isolation of electrophoretically homogeneous, crystalline glyceraldehyde-3-phosphate dehydrogenase from lamprey muscles is described. Amino acid composition of the enzy... | [
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PMID:17251 | [Molecular evolution of glycogen phosphorylase and aminotransferases of vertebrate muscle tissue]. | Comparative biochemical studies on phosphorylase b, aspartate aminotransferase and alanine aminotransferase in muscles of various vertebrates (the lamprey Lampetra fluviatilis, dogfish Squalus acanthias, rays Dasyatis pastinaca and Raja clavata, teleosts Scorpaena porcus, Spicara smaris, Esox lucius, Tinca tinca, Abram... | [Molecular evolution of glycogen phosphorylase and aminotransferases of vertebrate muscle tissue]. Comparative biochemical studies on phosphorylase b, aspartate aminotransferase and alanine aminotransferase in muscles of various vertebrates (the lamprey Lampetra fluviatilis, dogfish Squalus acanthias, rays Dasyatis pas... | [
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PMID:17256 | Purification and properties of L-asparaginase EC-2 from Escherichia coli 055:B5. | 1. L-Asparaginase has been isolated from aerobically grown Escherichia coli 055:B5 and purified about 140-fold in a three-step procedure involving acidification to pH 4.5, ammonium sulphate fractionation and column chromatography on DEAE-Sephadex A-50. The activity of the preparation is 140 U/mg protein. 2. The enzyme ... | Purification and properties of L-asparaginase EC-2 from Escherichia coli 055:B5. 1. L-Asparaginase has been isolated from aerobically grown Escherichia coli 055:B5 and purified about 140-fold in a three-step procedure involving acidification to pH 4.5, ammonium sulphate fractionation and column chromatography on DEAE-S... | [
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PMID:17257 | Increased serum prolactin in diabetic ketoacidosis; correlation between serum sodium and serum prolacting concentration. | In 8 patients with diabetic ketoacidosis, serum prolactin was measured and found to be elevated (24.8 +/- 10.2 ng/ml, mean +/- SEM). After correction of the ketoacidosis, the prolactin level decreased to 10.9 +/- 6.4 ng/ml (normal range men 4.9 +/-0.8, women 5.1 +/- 1.6 ng/ml). The scatter of prolactin values was wide.... | Increased serum prolactin in diabetic ketoacidosis; correlation between serum sodium and serum prolacting concentration. In 8 patients with diabetic ketoacidosis, serum prolactin was measured and found to be elevated (24.8 +/- 10.2 ng/ml, mean +/- SEM). After correction of the ketoacidosis, the prolactin level decrease... | [
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PMID:17258 | Characterization of human ovarian oestradiol-17 beta oxidoreductase activity. | Oestradiol-17 beta oxidoreductase activity, which catalyzes the interconversion of oestrone and oestradiol, was investigated in preparations of human ovaries. The enzyme activities were localized primarily in the 105,000 X g supernatant fraction; dialyzed supernatant preparations were used in subsequent studies. The pH... | Characterization of human ovarian oestradiol-17 beta oxidoreductase activity. Oestradiol-17 beta oxidoreductase activity, which catalyzes the interconversion of oestrone and oestradiol, was investigated in preparations of human ovaries. The enzyme activities were localized primarily in the 105,000 X g supernatant fract... | [
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PMID:17259 | Pituitary LH and FSH and testosterone secretion in infants with undescended testes. | Twelve male infants with undescended testes (5 bilaterally, 7 unilaterally) were studied between the ages of 1 week and 11 months. As in older pre-pubertal cryptorchid boys, a significant decrease of the LH response to LH-RH test was found, while basal plasma levels of gonadotrophins and FSH response to LH-RH were norm... | Pituitary LH and FSH and testosterone secretion in infants with undescended testes. Twelve male infants with undescended testes (5 bilaterally, 7 unilaterally) were studied between the ages of 1 week and 11 months. As in older pre-pubertal cryptorchid boys, a significant decrease of the LH response to LH-RH test was fo... | [
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PMID:17262 | Postoperative synovial fluid. Metabolic response to meniscectomy or synovectomy. | The metabolic response of synovial tissue to surgery was investigated by synovial fluid analysis after two types of operations, medial meniscectomy and synovectomy. Analyses of intra-articular fluid were also performed in non-operated patients with traumatic effusion or chronic synovitis in the knee. It was found that ... | Postoperative synovial fluid. Metabolic response to meniscectomy or synovectomy. The metabolic response of synovial tissue to surgery was investigated by synovial fluid analysis after two types of operations, medial meniscectomy and synovectomy. Analyses of intra-articular fluid were also performed in non-operated pati... | [
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PMID:17263 | Infantile polyarteritis and Kawasaki disease. | Polyarteritis in infancy is very rare, difficult to diagnose and invariably fatal. A 6-month-old girl who presented with a prolonged unexplained fever and was subsequently demonstrated at post-mortem examination to have polyarteritis is described. The combination of polyarterits with some unusual presenting features su... | Infantile polyarteritis and Kawasaki disease. Polyarteritis in infancy is very rare, difficult to diagnose and invariably fatal. A 6-month-old girl who presented with a prolonged unexplained fever and was subsequently demonstrated at post-mortem examination to have polyarteritis is described. The combination of polyart... | [
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PMID:17267 | [Behavior therapy and sex therapy]. | The author attempts to situate sextherapy of Masters and Johnson in relation to behaviour therapy in indicating the principles elaborated by old behaviour therapy and its most recent developments which are at the origin of sextherapy. He also considers the problem of indications and complementary relation which can be ... | [Behavior therapy and sex therapy]. The author attempts to situate sextherapy of Masters and Johnson in relation to behaviour therapy in indicating the principles elaborated by old behaviour therapy and its most recent developments which are at the origin of sextherapy. He also considers the problem of indications and ... | [
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PMID:17268 | Hyperthermic tumour-cell devitalization in vivo. | A review of the morphologic, biochemical and clinical effects of hyperthermia on malignant cells indicates the presence of two principally different heat-induced alterations. (1) A 'destructive' lysosomal dependent cytoplasmic reaction dominates the tumour-cell devitalization in vivo, probably influenced by the charact... | Hyperthermic tumour-cell devitalization in vivo. A review of the morphologic, biochemical and clinical effects of hyperthermia on malignant cells indicates the presence of two principally different heat-induced alterations. (1) A 'destructive' lysosomal dependent cytoplasmic reaction dominates the tumour-cell devitaliz... | [
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PMID:17264 | Acid base equilibrium in experimental acidosis of cows with and without rumen fistula. | Acid base equilibrium in experimental acidosis of cows with and without rumen fistula. Acta Physiol. Pol., 1977, 28, (1): 77-84. Symptoms of acidosis caused by administration of saccharose into the rumen were more significant and lasted longer in the cows without rumen fistula than in those with it. At the peak of acid... | Acid base equilibrium in experimental acidosis of cows with and without rumen fistula. Acid base equilibrium in experimental acidosis of cows with and without rumen fistula. Acta Physiol. Pol., 1977, 28, (1): 77-84. Symptoms of acidosis caused by administration of saccharose into the rumen were more significant and las... | [
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PMID:17269 | Photolysis of desmosine and isodesmosine by ultraviolet light. | It is known that the pyridinium ring of a model compound such as N-methyl pyridinium chloride is cleaved by U.V. radiation at 254 nm. At acid pH the products obtained are methylamine and glutaconaldehyde. Under the same conditions desmosine and isodesmosine are degraded into lysine and probably into the homologous subs... | Photolysis of desmosine and isodesmosine by ultraviolet light. It is known that the pyridinium ring of a model compound such as N-methyl pyridinium chloride is cleaved by U.V. radiation at 254 nm. At acid pH the products obtained are methylamine and glutaconaldehyde. Under the same conditions desmosine and isodesmosine... | [
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PMID:17265 | The influence of histamine on metabolism of dopamine and serotonin in the rat striatum. | The influence of histamine on metabolism of dopamine and serotonin in the rat striatum. Acta Physiol. Pol., 1977, 28 (2): 101--105. Histamine-2HC1 (Hi) given in a dose of 500 micron g did not change DA level in the striatum but HVA was increased by approx. 50%. The Hi-induced rise of HVA level was prevented in animals ... | The influence of histamine on metabolism of dopamine and serotonin in the rat striatum. The influence of histamine on metabolism of dopamine and serotonin in the rat striatum. Acta Physiol. Pol., 1977, 28 (2): 101--105. Histamine-2HC1 (Hi) given in a dose of 500 micron g did not change DA level in the striatum but HVA ... | [
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PMID:17272 | Studies on lysyl oxidase of bovine ligamentum nuchae and bovine aorta. | Lysyl oxidase had been purified to near homogeneity from bovine aorta and bovine ligamentum nuchae employing a modification of methods described by Harris et al., and Stassen and his colleagues. The aortic enzyme gives rise to at least three peaks and the ligament enzyme resolves into at least four peaks upon chromatog... | Studies on lysyl oxidase of bovine ligamentum nuchae and bovine aorta. Lysyl oxidase had been purified to near homogeneity from bovine aorta and bovine ligamentum nuchae employing a modification of methods described by Harris et al., and Stassen and his colleagues. The aortic enzyme gives rise to at least three peaks a... | [
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PMID:17274 | The coacervate-sol transition observed with alpha-elastin and its N-formyl O-methyl derivative. | The coacervate phase produced by raising the temperature of solutions of blocked alpha-elastin has water content and fibrillar structure at electron microscope level similar to fibrous elastin (Cox, B.A., Starcher, B.C., Urry, D.W. (1973) Biochim, Biophys. Acta 317, 209-213). The stability ranges of the coacervates und... | The coacervate-sol transition observed with alpha-elastin and its N-formyl O-methyl derivative. The coacervate phase produced by raising the temperature of solutions of blocked alpha-elastin has water content and fibrillar structure at electron microscope level similar to fibrous elastin (Cox, B.A., Starcher, B.C., Urr... | [
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PMID:17277 | Purification of vaccinia virus by zonal centrifugation and analysis of viral protein composition. | Vaccinia virus propagated in rotated cultures of RK13 cells was purified by sucrose density gradient zonal centrifugation. The purified virus was dissociated with sodium dodecyl sulfate end its protein composition analyzed by polyacrylamide gel electrophoresis. The protein composition of the virion envelope, isolated b... | Purification of vaccinia virus by zonal centrifugation and analysis of viral protein composition. Vaccinia virus propagated in rotated cultures of RK13 cells was purified by sucrose density gradient zonal centrifugation. The purified virus was dissociated with sodium dodecyl sulfate end its protein composition analyzed... | [
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PMID:17278 | Effect of influenza virus on the immune responsiveness of animals. | Infection of mice with A/Hong Kong/1/68 (H3N2) and A/PR8/34 (H0N1) influenza virus strains resulted in a significant inhibition of the formation of antibody-producing cells in response to administration of sheep erythrocytes and a reduced capacity of spleen cells to induce "graft-versus-host" reaction. The immunosuppre... | Effect of influenza virus on the immune responsiveness of animals. Infection of mice with A/Hong Kong/1/68 (H3N2) and A/PR8/34 (H0N1) influenza virus strains resulted in a significant inhibition of the formation of antibody-producing cells in response to administration of sheep erythrocytes and a reduced capacity of sp... | [
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PMID:17279 | Effects of tilorone hydrochloride on experimental flavivirus infections in mice. | The effect of tilorone hydrochloride on experimental infections of mice with West Nile, Langat and Dengue type 2 viruses were studied. The drug significantly reduced the mortality after intraperitoneal inoculation of West Nile virus, but failed to affect intracerebral infection with Langat or Dengue viruses. Tilorone p... | Effects of tilorone hydrochloride on experimental flavivirus infections in mice. The effect of tilorone hydrochloride on experimental infections of mice with West Nile, Langat and Dengue type 2 viruses were studied. The drug significantly reduced the mortality after intraperitoneal inoculation of West Nile virus, but f... | [
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PMID:17280 | Experimental Hazara Virus infection in mice. | Reproduction of Hazara virus in intracerebrally (ic) inoculated newborn white mice was studied by virological, serological and histological methods, electron microscopy and the direct fluorescent antibody technique. In the course of infection the virus was detectable in the blood, brain and some viscera, the largest am... | Experimental Hazara Virus infection in mice. Reproduction of Hazara virus in intracerebrally (ic) inoculated newborn white mice was studied by virological, serological and histological methods, electron microscopy and the direct fluorescent antibody technique. In the course of infection the virus was detectable in the ... | [
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PMID:17281 | Susceptibility of laboratory and domestic animals to experimental infection with Orungo virus. | Laboratory and domestic animals: mice, hamsters, rabbits, sparrows, chickens and lambs were inoculated with Orungo virus to determine their susceptibility as evidenced by clinical response, viraemia and antibody development. Mice and hamsters circulated the virus and developed neutralising antibodies; clinical signs of... | Susceptibility of laboratory and domestic animals to experimental infection with Orungo virus. Laboratory and domestic animals: mice, hamsters, rabbits, sparrows, chickens and lambs were inoculated with Orungo virus to determine their susceptibility as evidenced by clinical response, viraemia and antibody development. ... | [
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PMID:17283 | The antiviral activity of dipyridamole. | Dipyridamole, a coronary vasodilatator, was found to possess antiviral activity against representatives of different families. The antiviral properties were studied in chick embryo, human diplid and FL cell cultures by the agar diffusion plaque inhibition and plaque reduction tests and one-step growth cycle experiments... | The antiviral activity of dipyridamole. Dipyridamole, a coronary vasodilatator, was found to possess antiviral activity against representatives of different families. The antiviral properties were studied in chick embryo, human diplid and FL cell cultures by the agar diffusion plaque inhibition and plaque reduction tes... | [
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PMID:17284 | Enzymatic activity of blood lymphocytes experimental tsutsugamushi fever in mice. | The influence of tsutsugamushi fever infection on the metabolism of blood lymphocytes of mice differing in susceptibility to Rickettsia tsutsugamushi and of rifampicine and tetracycline treatment was studied. In susceptible mice, the activity of oxidation-reduction processes in lymphocytes increased at 7--10 days of th... | Enzymatic activity of blood lymphocytes experimental tsutsugamushi fever in mice. The influence of tsutsugamushi fever infection on the metabolism of blood lymphocytes of mice differing in susceptibility to Rickettsia tsutsugamushi and of rifampicine and tetracycline treatment was studied. In susceptible mice, the acti... | [
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PMID:17285 | Purification of free polyhedrosis virus infecting Galleria mellonella L. | Free Galleria mellonella nuclear polyhedrosis virus was purified 4000--4500 times by Tween-80 treatment and repeated sucrose density gradient centrifugation, based on the ratio of infectivity to protein content as compared to the starting virus-containing suspension. | Purification of free polyhedrosis virus infecting Galleria mellonella L. Free Galleria mellonella nuclear polyhedrosis virus was purified 4000--4500 times by Tween-80 treatment and repeated sucrose density gradient centrifugation, based on the ratio of infectivity to protein content as compared to the starting virus-co... | [
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PMID:17286 | Biological characteristic of Nigerian strains of West Nile virus in mice and cell cultures. | The biological characteristic in mice and cell cultures of 7 strains of West Nile (WN) virus isolated in Nigeria were studied. The pattern of virus development in most organs of mice infected with two of the seven strains tested was identical, while it varied with the remaining five strains. All 7 strains of WN virus m... | Biological characteristic of Nigerian strains of West Nile virus in mice and cell cultures. The biological characteristic in mice and cell cultures of 7 strains of West Nile (WN) virus isolated in Nigeria were studied. The pattern of virus development in most organs of mice infected with two of the seven strains tested... | [
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PMID:17287 | Serotyping of coxsackieviruses by immune electron microscopy. | Coxsackieviruses B1, B2 and B3 were identified by immune electron microscopy. The results were in good agreement with those of virus neutralization tests in cell cultures. | Serotyping of coxsackieviruses by immune electron microscopy. Coxsackieviruses B1, B2 and B3 were identified by immune electron microscopy. The results were in good agreement with those of virus neutralization tests in cell cultures. | [
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PMID:17288 | Plaque formation by alphavirus (Getah) in Culex Mosquito cells. | Plaques were formed by Getah virus (an Alphavirus) which had been grown in BHK cells and passaged once in Culex cells before inoculation of Culex cell cultures. Plaques were not produced either by Getah or Japanese encephalitis (JE) viruses which had been passaged only in BHK cells. Plaque counts in Culex cell monolaye... | Plaque formation by alphavirus (Getah) in Culex Mosquito cells. Plaques were formed by Getah virus (an Alphavirus) which had been grown in BHK cells and passaged once in Culex cells before inoculation of Culex cell cultures. Plaques were not produced either by Getah or Japanese encephalitis (JE) viruses which had been ... | [
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PMID:17289 | Role of normal cell antigens in the establishment of measles virus in newborn white mice. | The Edmontson strain of measles virus was adapted to the brains of newborn white mice to which extracts from African green monkey kidney (Vero) cells used for maintenance of measles virus had been injected intracerebrally. The animals showed symptoms of involvement of the central nervous system (pareses, paralyses) whi... | Role of normal cell antigens in the establishment of measles virus in newborn white mice. The Edmontson strain of measles virus was adapted to the brains of newborn white mice to which extracts from African green monkey kidney (Vero) cells used for maintenance of measles virus had been injected intracerebrally. The ani... | [
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PMID:17292 | Interaction of plasma membranes with influenza virus. VII. Effect on 3',5'-cyclic adenosine monophosphate phosphodiesterase activity. | In chick embryo cells (CEC) and plasma membranes (PM) isolated therefrom, three forms of 3',5'-cyclic adenosine monophosphate (cAMP) phosphodiesterase (PDE) were demonstrated: (1) PDE activated only by Ca2+ (Ca-PDE); (2) PDE activated only by Mg2+ (Mg-PDE); and (3) PDE stimulated in the presence of 2 mM Mg2+ by low con... | Interaction of plasma membranes with influenza virus. VII. Effect on 3',5'-cyclic adenosine monophosphate phosphodiesterase activity. In chick embryo cells (CEC) and plasma membranes (PM) isolated therefrom, three forms of 3',5'-cyclic adenosine monophosphate (cAMP) phosphodiesterase (PDE) were demonstrated: (1) PDE ac... | [
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PMID:17294 | Reduced renal acid excretion in malnutrition: a result of phosphate depletion. | Eleven infants recovering from protein-calorie malnutrition secondary to acquired monosaccharide intolerance were found to have reduced plasma bicarbonate concentration associated with inadequate weight gain. Renal net acid excretion (NAE) was decreased to a mean of 34.2 micronEq/1.73m2/min. Titratable acidity (TA) was... | Reduced renal acid excretion in malnutrition: a result of phosphate depletion. Eleven infants recovering from protein-calorie malnutrition secondary to acquired monosaccharide intolerance were found to have reduced plasma bicarbonate concentration associated with inadequate weight gain. Renal net acid excretion (NAE) w... | [
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PMID:17295 | Contribution of arterial blood lactate measurement to the care of critically ill patients. | Arterial blood samples from 202 critically ill patients were studied. Lactate concentration, PO2, PCO2, pH, oxygen saturation, total CO2, and toe temperature were measured. Base excess, buffer base, actual bicarbonate, and standard bicarbonate were calculated. Analysis of the initial data obtained from each patient rev... | Contribution of arterial blood lactate measurement to the care of critically ill patients. Arterial blood samples from 202 critically ill patients were studied. Lactate concentration, PO2, PCO2, pH, oxygen saturation, total CO2, and toe temperature were measured. Base excess, buffer base, actual bicarbonate, and standa... | [
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PMID:17297 | The pediatric practice of the child health associate. | Child health associates are individuals who have completed the three-year Child Health Associate Program at the University of Colorado School of Medicine and are certified by the Colorado State Board of Medical Examiners to practice pediatrics under physician supervision. To our knowledge, this study is the first to de... | The pediatric practice of the child health associate. Child health associates are individuals who have completed the three-year Child Health Associate Program at the University of Colorado School of Medicine and are certified by the Colorado State Board of Medical Examiners to practice pediatrics under physician superv... | [
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... |
PMID:17298 | Immunologic studies and clinical follow-up HBsAg-positive polyarteritis nodosa. | Three patients with hepatitis B surface antigen (HBsAg)-positive polyarteritis nodosa (PAN) who are clinically well 4 1/2-5 1/2 years after their initial illnesses are described. In each case electron microscopic studies demonstrated the presence of aggregates of HBsAg in both acute and quiescent phase sera. One patien... | Immunologic studies and clinical follow-up HBsAg-positive polyarteritis nodosa. Three patients with hepatitis B surface antigen (HBsAg)-positive polyarteritis nodosa (PAN) who are clinically well 4 1/2-5 1/2 years after their initial illnesses are described. In each case electron microscopic studies demonstrated the pr... | [
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PMID:17299 | Idiopathic proctitis. I. The morphology of proximal colonic mucosa and its clinical significance. | A group of 31 patients with idiopathic proctitis were colonoscoped while they were symptomatic. Multiple mucosal biopsies were taken from the transverse, descending, and sigmoid colon and from the rectum. While visualization by colonoscopy revealed abnormalities limited to the most distal 18-20 cm of the colon, microsc... | Idiopathic proctitis. I. The morphology of proximal colonic mucosa and its clinical significance. A group of 31 patients with idiopathic proctitis were colonoscoped while they were symptomatic. Multiple mucosal biopsies were taken from the transverse, descending, and sigmoid colon and from the rectum. While visualizati... | [
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PMID:17301 | Low-dose methazolamide and intraocular pressure. | Sixteen patients with increased intraocular pressure (over 20 mm Hg) received 25 and 50 mg of oral methazolamide, twice daily, during consecutive weeks and then 500 mg (Sequels) of acetazolamide. The two methazolamide regimens produced significant decreases in intraocular pressure. Acetazolamide treatment resulted in a... | Low-dose methazolamide and intraocular pressure. Sixteen patients with increased intraocular pressure (over 20 mm Hg) received 25 and 50 mg of oral methazolamide, twice daily, during consecutive weeks and then 500 mg (Sequels) of acetazolamide. The two methazolamide regimens produced significant decreases in intraocula... | [
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PMID:17302 | Clinical implications of benzodiazepine pharmacokinetics. | Pharmacokinetic research has shown that clear differences exist among benzodiazepines in rate and route of elimination and in the presence or absence of pharmacologically active metabolites. These findings and other results of pharmacokinetic research have clinical implications in terms of dosage schedules, drug accumu... | Clinical implications of benzodiazepine pharmacokinetics. Pharmacokinetic research has shown that clear differences exist among benzodiazepines in rate and route of elimination and in the presence or absence of pharmacologically active metabolites. These findings and other results of pharmacokinetic research have clini... | [
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PMID:17303 | The role of benzodiazepines in nonpsychiatric medical practice. | The benzodiazepines are widely prescribed by many physicians for patients with depression, anxiety reaction, circulatory disorders, digestive disorders, tension headache, and pain in chest and back. According to various studies there is reason to believe that benzodiazepines not only possess the anxiolytic effects univ... | The role of benzodiazepines in nonpsychiatric medical practice. The benzodiazepines are widely prescribed by many physicians for patients with depression, anxiety reaction, circulatory disorders, digestive disorders, tension headache, and pain in chest and back. According to various studies there is reason to believe t... | [
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PMID:17304 | Brain mechanisms associated with therapeutic actions of benzodiazepines: focus on neurotransmitters. | The sedative, muscle relaxant, antianxiety, and anticonvulsant effects of benzodiazepines may involve several distinct mechanisms because dissociation among these actions can be demonstrated with various drugs. Neurotransmitters displaying prominent interactions with benzodiazepines include gamma-aminobutyric acid (GAB... | Brain mechanisms associated with therapeutic actions of benzodiazepines: focus on neurotransmitters. The sedative, muscle relaxant, antianxiety, and anticonvulsant effects of benzodiazepines may involve several distinct mechanisms because dissociation among these actions can be demonstrated with various drugs. Neurotra... | [
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PMID:17305 | Benzodiazepines: behavioral and neurochemical mechanisms. | The therapeutic effects of benzodiazepines in psychoneurosis may depend in part on their ability to release or disinhibit a patient's anxiety-suppressed gratification-seeking behavior. Benzodiazepines may disinhibit behavior by reducing the activity of serotonin (and possibly acetylcholine) neurons in the brain's "puni... | Benzodiazepines: behavioral and neurochemical mechanisms. The therapeutic effects of benzodiazepines in psychoneurosis may depend in part on their ability to release or disinhibit a patient's anxiety-suppressed gratification-seeking behavior. Benzodiazepines may disinhibit behavior by reducing the activity of serotonin... | [
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PMID:17306 | Neural mechanisms of benzodiazepine actions. | Current experimental paradigms emphasize neurotransmitter-specific interactions to explain the behavioral effects of benzodiazepines. According to this approach the broad range of effects observed suggests the involvement of several transmitter systems without rigorously establishing that any single transmitter system ... | Neural mechanisms of benzodiazepine actions. Current experimental paradigms emphasize neurotransmitter-specific interactions to explain the behavioral effects of benzodiazepines. According to this approach the broad range of effects observed suggests the involvement of several transmitter systems without rigorously est... | [
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