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|---|---|---|---|---|---|---|---|---|
54fc845e6ea36a810c000005 | yesno | Was modafinil tested for schizophrenia treatment? | [
"Yes. Modafinil has been shown to improve attention, memory, executive function and antipsychotic-induced parkinsonism in patients with schizophrenia. However, some authors have failed to demonstrate beneficial action of modafinil for schizophrenia."
] | [
"yes"
] | [
"Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study.",
"CONCLUSION: The data suggest that modafinil was a safe adjunctive treatment which i... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21412225",
"http://www.ncbi.nlm.nih.gov/pubmed/15085092",
"http://www.ncbi.nlm.nih.gov/pubmed/19572020",
"http://www.ncbi.nlm.nih.gov/pubmed/23983964",
"http://www.ncbi.nlm.nih.gov/pubmed/17151173",
"http://www.ncbi.nlm.nih.gov/pubmed/22820555",
"http://www.ncbi.nlm.n... | [] | [
"http://www.biosemantics.org/jochem#4259639",
"http://www.disease-ontology.org/api/metadata/DOID:5419"
] |
5541ffc3472cfd8617000004 | summary | What is the role of the Ada O6-alkylguanine alkyltransferase in bacteria? | [
"The Ada O6-methylguanine-DNA methyltransferase is a multifunctional protein, product of the ada gene. Ada functions in DNA repair by direct dealkylation of alkylated DNA lesions, such as the toxic, mutagenic and carcinogenic O6-alkylguanine (O6-AlkG) and O4-alkylthymine (O4-AlkT) which are restored to guanine and ... | [] | [
"multifunctional 39 kDa Escherichia coli Ada protein (O6-methylguanine-DNA methyltransferase) (EC 2.1.1.63), product of the ada gene",
"The Ada protein accepts stoichiometrically the alkyl group from O6-alkylguanine in DNA at the Cys-321 residue and from alkyl phosphotriester at the Cys-69 residue. This protein f... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10101186",
"http://www.ncbi.nlm.nih.gov/pubmed/9079656",
"http://www.ncbi.nlm.nih.gov/pubmed/7695814",
"http://www.ncbi.nlm.nih.gov/pubmed/9366274",
"http://www.ncbi.nlm.nih.gov/pubmed/3526284",
"http://www.ncbi.nlm.nih.gov/pubmed/1747932",
"http://www.ncbi.nlm.nih.go... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003908",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019853",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009617",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:... |
56cf4b623975bb303a00000a | list | List the neurotransmitters that are metabolized by MAOA. | [
"The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine."
] | [
"serotonin",
"norepinephrine",
"dopamine"
] | [
" MAOA metabolizes monoamine neurotransmitters. ",
"Monoamine oxidase A (MAOA) modulates metabolism of serotonin and dopamine metabolism, neurotransmitters involved in regulation of appetite and food intake. ",
"Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression o... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19214141",
"http://www.ncbi.nlm.nih.gov/pubmed/24652311",
"http://www.ncbi.nlm.nih.gov/pubmed/24865426",
"http://www.ncbi.nlm.nih.gov/pubmed/23761378",
"http://www.ncbi.nlm.nih.gov/pubmed/24510409",
"http://www.ncbi.nlm.nih.gov/pubmed/25733484",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018377",
"http://www.uniprot.org/uniprot/AOFA_BOVIN",
"http://www.uniprot.org/uniprot/AOFA_CANFA"
] |
55450521bf90a13052000001 | factoid | What is the effect of enamel matrix derivative on pulp regeneration? | [
"EMD increased the osteogenic potential of hDPCs. The expression levels of osteogenesis-related genes, such as ALP, DSPP, BMP, and OPN were also upregulated. In addition, the expression levels of odontogenesis-related transcription factors Osterix and Runx2 were upregulated. Proliferated pulp tissue partly filled t... | [
"increase of the osteogenic potential of hDPCs"
] | [
"Among the human studies, two studies reported that EMD is a more efficient DPC procedure compared with calcium hydroxide (Ca(OH)2 ). One study reported Ca(OH)2 to be more efficient for DPC than EMD. One study reported no difference in the efficacies between EMD and Ca(OH)2 for DPC. All animal studies reported EMD ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12640753",
"http://www.ncbi.nlm.nih.gov/pubmed/24246686",
"http://www.ncbi.nlm.nih.gov/pubmed/21166828",
"http://www.ncbi.nlm.nih.gov/pubmed/24279667",
"http://www.ncbi.nlm.nih.gov/pubmed/23880267"
] | [] | [] |
514cc8dcd24251bc05000066 | yesno | Is depression associated with poor prognosis of brain tumor patients? | [
"Yes. In brain tumor patients depression is associated with shorter survival and worse functional outcomes."
] | [
"yes"
] | [
"Before surgery 27 patients (35%) had BDI scores indicating the presence of depression. These scores were significantly higher in patients with a history of depression (p = 0.017) and in those with a lower functional outcome (p = 0.015).",
"A lower functional status (KPS score < or = 70) in patients was significa... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16304988",
"http://www.ncbi.nlm.nih.gov/pubmed/15072475",
"http://www.ncbi.nlm.nih.gov/pubmed/15918939",
"http://www.ncbi.nlm.nih.gov/pubmed/16960653"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003863",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016019",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017063",
"http://www.nlm.nih.gov/cgi/mesh/2... |
51430930d24251bc0500000b | summary | Super-SILAC is a method used in quantitative proteomics. What is the super-SILAC mix?
(SILAC: Stable Isotopic labelling by aminoacids in cell culture) | [
"The Super-SILAC mix consists of the combination of multiple SILAC-labeled cell lines."
] | [] | [
", a mixture of five SILAC-labeled cell lines that accurately represents the tissue",
"We describe a method to accurately quantify human tumor proteomes by combining a mixture of five stable-isotope labeling by amino acids in cell culture (SILAC)-labeled cell lines with human carcinoma tissue. "
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/21293456",
"http://www.ncbi.nlm.nih.gov/pubmed/20364148",
"http://www.ncbi.nlm.nih.gov/pubmed/22278370",
"http://www.ncbi.nlm.nih.gov/pubmed/20431548",
"http://www.ncbi.nlm.nih.gov/pubmed/23090970",
"http://www.ncbi.nlm.nih.gov/pubmed/22442255",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020543",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D040901",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007553"
] |
533c390bc45e13371400000b | factoid | What is an acceptable sequence coverage(depth) required for human whole-exome sequencing? | [
"A medium depth may be considered as 8x while the most common values vary between 30x and 60x. Values more than 75x or even up to 125x may be considered for the investigation of rare disease variants."
] | [
"30x-60x"
] | [
"A total of 5.97 Gb clean data were generated for the two samples, achieving a mean depth of coverage of 31.96 and 32.88 for the AAA and normal samples, respectively.",
"The 1.7 Mb targeted regions were sequenced with a coverage ranged from 32× to 45× for the 28 genes.",
"We performed whole-exome sequencing on ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22038007",
"http://www.ncbi.nlm.nih.gov/pubmed/23272691",
"http://www.ncbi.nlm.nih.gov/pubmed/21499249",
"http://www.ncbi.nlm.nih.gov/pubmed/23160641",
"http://www.ncbi.nlm.nih.gov/pubmed/23647072",
"http://www.ncbi.nlm.nih.gov/pubmed/24290377",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D059014",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006801",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017422",
"http://www.nlm.nih.gov/cgi/mesh/2... |
531a3a58b166e2b806000037 | factoid | To what extent does HPV vaccination reduce the risk for cervical cancer? | [
"The most effective strategy therein was vaccination of 12-year-olds, plus a temporary 12-24-year-old catch-up program covering both sexes; whereby HPV 6/11/16/18-related cervical cancer, high-grade cervical precancer, and genital wart incidence was reduced by 84-98% during year 50 following vaccine introduction. V... | [
"Cervical precancer and similar neoplasias were reduced by 84-100%"
] | [
"The success of HPV vaccination as a major public health prevention opportunity, however, will entirely depend on efficient infrastructures to deliver the vaccines and on the acceptance by individuals, parents and health care providers.",
"The most effective strategy therein was vaccination of 12-year-olds, plus ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18482556",
"http://www.ncbi.nlm.nih.gov/pubmed/19901442",
"http://www.ncbi.nlm.nih.gov/pubmed/19901441",
"http://www.ncbi.nlm.nih.gov/pubmed/18055075",
"http://www.ncbi.nlm.nih.gov/pubmed/21245659",
"http://www.ncbi.nlm.nih.gov/pubmed/17318575",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014611",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053918",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014612",
"http://www.disease-ontology.org/a... |
5161cfa3298dcd4e5100003d | yesno | Have germline variants been associated to colorectal cancer? | [
"Yes. Whole-genome sequencing (WGS) applied to medical research has revealed how germline variants and mutations may be associated with colorectal cancer. It is likely that this level of knowledge can be translated into predictions of predisposition."
] | [
"yes"
] | [
"Overall, we identified aberrant transcripts in 8% of the patients (familial cases 30%; early-onset manifestation 21%). In eight of them, two different out-of-frame pseudoexons were found consisting of a 167-bp insertion from intron 4 in five families with a shared founder haplotype and a 83-bp insertion from intro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22020387",
"http://www.ncbi.nlm.nih.gov/pubmed/21351276",
"http://www.ncbi.nlm.nih.gov/pubmed/22431159",
"http://www.ncbi.nlm.nih.gov/pubmed/17524638",
"http://www.ncbi.nlm.nih.gov/pubmed/18091433",
"http://www.ncbi.nlm.nih.gov/pubmed/17604324",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017422",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D059014"
] |
5156beb4d24251bc05000089 | yesno | Can Alzheimer's disease related miRNAs be detected in patients' blood? | [
"Yes. It has been demonstrated that blood miRNAs could be useful as biomarkers in Alzheimer's disease."
] | [
"yes"
] | [
"miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD."... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23030236",
"http://www.ncbi.nlm.nih.gov/pubmed/23054683",
"http://www.ncbi.nlm.nih.gov/pubmed/21548758",
"http://www.ncbi.nlm.nih.gov/pubmed/22155483",
"http://www.ncbi.nlm.nih.gov/pubmed/23435408",
"http://www.ncbi.nlm.nih.gov/pubmed/23528227",
"http://www.ncbi.nlm.n... | [
{
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"s": "http://purl.uniprot.org/pubmed/10477709",
"o": "Blood"
},
{
"p": "http://www.w3.org/2004/02/skos/core#exactMatch",
"s": "http://purl.uniprot.org/pubmed/10339464",
"o": "http://purl.uniprot.org/pubmed/10339464"
},
{
"p": "http://pu... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D035683",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001773",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=diseases_category",
"http://www.nlm.nih.gov/... |
5339edd6d6d3ac6a34000061 | factoid | Which is the clinical meaning of the presence of delayed enhancement in patients with hypertrophic cardiomyopathy? | [
"Occurrence of myocardial fibrosis in hypertrophic cardiomyopathy is associated with left atrial and ventricular dysfunction as well as with the severity of heart failure symptoms and arrhythmic risk factors."
] | [
"In patients with hypertrophic cardiomyopathy delayed enhancement is associated with heart failure symptoms and left ventricular systolic dysfunction and arrhythmic risk"
] | [
"The extent of regional myocardial fibrosis is associated with regional myocardial function independently of morphological changes of the myocardium, and the correlation extended to global LV function.",
"Occurrence of myocardial fibrosis in hypertrophic cardiomyopathy is associated with left atrial and ventricul... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18552138",
"http://www.ncbi.nlm.nih.gov/pubmed/21498307",
"http://www.ncbi.nlm.nih.gov/pubmed/20102955",
"http://www.ncbi.nlm.nih.gov/pubmed/18387438",
"http://www.ncbi.nlm.nih.gov/pubmed/19477402",
"http://www.ncbi.nlm.nih.gov/pubmed/23097128",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:11984",
"http://www.disease-ontology.org/api/metadata/DOID:11986",
"http://www.disease-ontology.org/api/metadata/DOID:0050700",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009682",
"http://www.nlm.nih.gov/cgi/mesh/2014... |
5156be17d24251bc05000086 | factoid | What disease is mirtazapine predominantly used for? | [
"Mirtazapine is predominantly used in the treatment of major depression."
] | [
"major depression"
] | [
"mirtazapine will make it the first-choice drug in depressive patients with gastric ulcers.",
"If antidepressants are used to treat insomnia, sedating ones should be preferred over activating agents such as serotonin reuptake inhibitors. In general, drugs lacking strong cholinergic activity should be preferred. D... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19034656",
"http://www.ncbi.nlm.nih.gov/pubmed/19412502",
"http://www.ncbi.nlm.nih.gov/pubmed/21810375",
"http://www.ncbi.nlm.nih.gov/pubmed/21071407",
"http://www.ncbi.nlm.nih.gov/pubmed/17440145",
"http://www.ncbi.nlm.nih.gov/pubmed/15052512",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/possibleDrug",
"s": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/852",
"o": "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00370"
},
{
"p": "http://www.w3.org/1999/02/22-rdf-syntax-ns#type",
"s":... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007202",
"http://www.biosemantics.org/jochem#4134182",
"http://www.biosemantics.org/jochem#4191931"
] |
54cf449cf693c3b16b000009 | yesno | Is it possible to visualize subtahalamic nucleus by using transcranial ultrasound? | [
"Yes, it has been shown that it is possible to visualize subtahalamic nucleus by using transcranial ultrasound. Transcranial ultrasound is safe and reliable method that can be employed to monitor lead location and intraoperative visualization of deep-brain stimulation (DBS) electrodes."
] | [
"yes"
] | [
"After measuring thermal effects of TCS and imaging artefact sizes of DBS lead using a skull phantom, we prospectively enrolled 34 patients with DBS of globus pallidus internus, ventro-intermediate thalamic or subthalamic nucleus. TCS had no influence on lead temperature, electrical parameters of DBS device or clin... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22941961",
"http://www.ncbi.nlm.nih.gov/pubmed/21683505",
"http://www.ncbi.nlm.nih.gov/pubmed/20846894",
"http://www.ncbi.nlm.nih.gov/pubmed/20692508",
"http://www.ncbi.nlm.nih.gov/pubmed/14745222",
"http://www.ncbi.nlm.nih.gov/pubmed/15639532"
] | [] | [] |
516e5f10298dcd4e5100007c | factoid | Is cancer related to global DNA hypo or hypermethylation? | [
"DNA hypermethylation and hypomethylation are independent processes and appear to play different roles in tumor progression. Cancer cells are characterized by a generalized disruption of the DNA methylation pattern involving an overall decrease in the level of 5-methylcytosine together with regional hypermethylati... | [
"Global hypomethylation is coupled with focal hypermethylation at CpG islands"
] | [
"Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer",
"Regions of focal hypermethylation in the tumor were located primarily at CpG islands and were concentrated within regions of long-range (>100 kb) hypomethylation. These hypomethylated domains covered nearly half of the g... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15574462",
"http://www.ncbi.nlm.nih.gov/pubmed/22120008",
"http://www.ncbi.nlm.nih.gov/pubmed/18667590",
"http://www.ncbi.nlm.nih.gov/pubmed/19639607",
"http://www.ncbi.nlm.nih.gov/pubmed/16317087",
"http://www.ncbi.nlm.nih.gov/pubmed/18974140",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:162",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0044026",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0044027",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0044028",
"http://amigo.geneontology.org/c... |
533e50fdc45e13371400000f | yesno | Do thyroid hormone receptors change after brain injury? | [
"thyroid hormone receptors increase after brain injury"
] | [
"yes"
] | [
"For example, the T3 receptor alpha was predominantly expressed in stroke-tissue, indicating that regeneration of nerves in stroke tissue may be facilitated by increased T3 receptor alpha expression.",
"TRα expression was also increased in human infants with IVH. ",
"Thus, in infants with IVH the combined eleva... | [
"http://www.ncbi.nlm.nih.gov/pubmed/14761671",
"http://www.ncbi.nlm.nih.gov/pubmed/24174657",
"http://www.ncbi.nlm.nih.gov/pubmed/6329444"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011988",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001930"
] |
54f0985994afd6150400001a | summary | What is known about efficacy of the high dose intravenous ascorbate in the treatment of cancer patients? | [
"It was reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. However, double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific communiti... | [] | [
"Evidence suggests that IVC may be able to modulate inflammation, which in turn might improve outcomes for cancer patients. IVC may serve as a safe, adjunctive therapy in clinical cancer care.",
"SIGNIFICANCE: Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was eff... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10963459",
"http://www.ncbi.nlm.nih.gov/pubmed/23947403",
"http://www.ncbi.nlm.nih.gov/pubmed/22205155",
"http://www.ncbi.nlm.nih.gov/pubmed/15068981",
"http://www.ncbi.nlm.nih.gov/pubmed/21672627",
"http://www.ncbi.nlm.nih.gov/pubmed/22963460",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:162"
] |
5540b9800083d1bf0e000002 | factoid | Alpha-spectrin and beta-spectrin subunits form parallel or antiparallel heterodimers? | [
"Alpha and beta spectrin subunits form antiparallel spectrin heterodimers by lateral association."
] | [
"antiparallel"
] | [
"α- and β-spectrin by LC-MS/MS identifies Cys in these antiparallel chains",
"antiparallel spectrin heterodimers",
"alpha- and beta-spectrins are stable as monomeric forms but occur physiologically as alpha,beta-heterodimers",
"human erythroid alpha-spectrin repeats 13 and 14 (HEalpha13,14) and human erythroi... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21527722",
"http://www.ncbi.nlm.nih.gov/pubmed/15522301",
"http://www.ncbi.nlm.nih.gov/pubmed/10652315",
"http://www.ncbi.nlm.nih.gov/pubmed/14747656",
"http://www.ncbi.nlm.nih.gov/pubmed/14761982",
"http://www.ncbi.nlm.nih.gov/pubmed/3517024",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.biosemantics.org/jochem#4249968",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008091"
] |
5321ae889b2d7acc7e000006 | yesno | Is gastro esophageal reflux related to burning mouth syndrome? | [
"No data indicate causal connection between gastro esophageal/laryngopharyngeal(LPR) reflux disease and the occurrence of intraoral burning sensations"
] | [
"no"
] | [
"Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients.",
"As reported below, although this symptom may well be diagnostically misleading, careful diagnosis based on clinical signs may distinguish patients with BMS f... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8725589",
"http://www.ncbi.nlm.nih.gov/pubmed/17849966",
"http://www.ncbi.nlm.nih.gov/pubmed/3244997",
"http://www.ncbi.nlm.nih.gov/pubmed/23201368",
"http://www.ncbi.nlm.nih.gov/pubmed/10546306",
"http://www.ncbi.nlm.nih.gov/pubmed/21359587",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002054",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005764",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004941",
"http://www.nlm.nih.gov/cgi/mesh/2... |
516545a8298dcd4e51000056 | factoid | Which is the protein (antigen) targeted by anti-Vel antibodies in the Vel blood group? | [
"Disruption of SMIM1 causes the Vel- blood type. The protein carrying the Vel blood group antigen was biochemically purified from red blood cell membranes. Mass spectrometry-based de novo peptide sequencing identified this protein to be small integral membrane protein 1 (SMIM1), a previously uncharacterized single-... | [
"SMIM1"
] | [
"Anti-Vel is an uncommon antibody to a high-prevalence antigen. Its clinical significance and management in the prenatal setting are not well characterized.",
"Haemolytic disease of the newborn because of rare anti-Vel.",
"A haemolytic anti-Vel was detected in the tube test. In contrast, the particular commerci... | [
"http://www.ncbi.nlm.nih.gov/pubmed/1823954",
"http://www.ncbi.nlm.nih.gov/pubmed/14617316",
"http://www.ncbi.nlm.nih.gov/pubmed/23505126",
"http://www.ncbi.nlm.nih.gov/pubmed/1304158",
"http://www.ncbi.nlm.nih.gov/pubmed/9745158",
"http://www.ncbi.nlm.nih.gov/pubmed/6522937",
"http://www.ncbi.nlm.nih.g... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001788",
"http://www.disease-ontology.org/api/metadata/DOID:4176",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001789",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Ex... |
52bf1d6003868f1b0600000e | list | Which are the subtypes of Pfeiffer syndrome? | [
"Pfeiffer syndrome is divided into three clinical subtypes.",
"Pfeiffer syndrome is divided into three clinical subtypes. Type 1 \"classic\" Pfeiffer syndrome involves individuals with mild manifestations including brachycephaly, midface hypoplasia and finger and toe abnormalities; it is associated with normal in... | [
"Type I",
"Type I (1)",
"Type II",
"Type II (2)",
"Type III",
"Type III (3)"
] | [
"Of 802 patients treated for craniosynostosis, 28 were identified with Pfeiffer syndrome: 17 were classified as type I (61 percent), seven were classified as type II (25 percent), and four were classified as type III (14 percent). ",
"Pfeiffer syndrome is divided into three clinical subtypes. Type 1 \"classic\" P... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11556600",
"http://www.ncbi.nlm.nih.gov/pubmed/19407629",
"http://www.ncbi.nlm.nih.gov/pubmed/9475589",
"http://www.ncbi.nlm.nih.gov/pubmed/8434615",
"http://www.ncbi.nlm.nih.gov/pubmed/11807866",
"http://www.ncbi.nlm.nih.gov/pubmed/15305355",
"http://www.ncbi.nlm.nih... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A18471228",
"o": "C537888"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A18471228",
"o": "Pfeiffer Mayer syndrome"
... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000168",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016130",
"http://www.disease-ontology.org/api/metadata/DOID:225",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exa... |
513cdc38bee46bd34c000007 | yesno | Is thrombophilia related to increased risk of miscarriage? | [
"Thrombophilia has been found to be considerably more common in women with pregnancy-associated complications in comparison with the general population, and most frequently in conjunction with venous thromboembolism during pregnancy and the postpartum period. In particular there is an increased risk of pregnancy-re... | [
"yes"
] | [
"Thrombophilia does hardly increase the risk of IUGR/PMPC or if so, it can be prevented by LMWH",
"for illustrative purposes, a patient presenting with combined thrombophilia--both genetic and acquired--will be discussed. This patient had suffered severe gestational complications that led to devastating obstetric... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11583310",
"http://www.ncbi.nlm.nih.gov/pubmed/16962918",
"http://www.ncbi.nlm.nih.gov/pubmed/19135285",
"http://www.ncbi.nlm.nih.gov/pubmed/15713144",
"http://www.ncbi.nlm.nih.gov/pubmed/15027582",
"http://www.ncbi.nlm.nih.gov/pubmed/7986734",
"http://www.ncbi.nlm.ni... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0007565",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018566",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019851",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=ui... |
514c3fd7d24251bc05000062 | factoid | Intact macromolecular assemblies are analysed by advanced mass spectrometry. How large complexes (in molecular weight) have been studied? | [
"2.3 megadalton"
] | [
"2.3 megadalton"
] | [
"Here we show that the Orbitrap mass analyzer can be used to measure protein assemblies of molecular weights approaching one megadalton with sensitivity down to the detection of single ions.",
"Using this relationship we show that we can determine masses of both 30S subunits and intact 2.3 MDa 70S ribosomes from ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23064518",
"http://www.ncbi.nlm.nih.gov/pubmed/8006040",
"http://www.ncbi.nlm.nih.gov/pubmed/19140748",
"http://www.ncbi.nlm.nih.gov/pubmed/16939266"
] | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0043933",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D046912",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013057",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=ui... |
56c1f01cef6e394741000044 | factoid | What is targeted by Palbociclib? | [
"Necitumumab is a fully human IgG(1) monoclonal antibody directed at the epidermal growth factor receptor (EGFR). It is used for treatment of nonsmall cell lung cancer."
] | [
"epidermal growth factor receptor"
] | [
"BACKGROUND: Necitumumab is a second-generation, recombinant, human immunoglobulin G1 EGFR antibody. ",
"Epidermal growth factor receptor-directed monoclonal antibodies in nonsmall cell lung cancer: an update.",
" A Southwest Oncology Group study currently prospectively evaluates the predictive biomarkers for c... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21815704",
"http://www.ncbi.nlm.nih.gov/pubmed/21679088",
"http://www.ncbi.nlm.nih.gov/pubmed/20197484",
"http://www.ncbi.nlm.nih.gov/pubmed/25701171",
"http://www.ncbi.nlm.nih.gov/pubmed/25636162",
"http://www.ncbi.nlm.nih.gov/pubmed/21806477",
"http://www.ncbi.nlm.n... | [] | [] |
56b1f4300a360a5e4500001b | factoid | Which peptide plays a pivotal role in human cystatin C fibrillization? | [
"Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological conditions it forms amyloid fibrils in brain arteries of young adults. An 'aggregation-prone' pentapeptide ((47)LQVVR(51)) ... | [
"LQVVR"
] | [
"Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological conditions it forms amyloid fibrils in brain arteries of young adults. An 'aggregation-prone' pentapeptide ((47)LQVVR(51)) ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25479090"
] | [] | [
"http://www.uniprot.org/uniprot/CYT_COTJA",
"http://www.uniprot.org/uniprot/CYT_CHICK",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015891",
"http://www.uniprot.org/uniprot/CYT_MICIK",
"http://www.biosemantics.org/jochem#4262068",
"http://www.biosemantics.org/jochem#... |
56af7b820a360a5e45000014 | summary | What is ChiRP-seq (Chromatin Isolation by RNA Purification sequencing)? | [
"ChiRP-seq (Chromatin Isolation by RNA Purification sequencing) is a method where tiling oligonucleotides retrieve specific lncRNAs with bound protein and DNA sequences, which are enumerated by deep sequencing. ChIRP-seq of three lncRNAs reveal that RNA occupancy sites in the genome are focal, sequence-specific, an... | [] | [
"Here we introduce Chromatin Isolation by RNA Purification (ChIRP), where tiling oligonucleotides retrieve specific lncRNAs with bound protein and DNA sequences, which are enumerated by deep sequencing. ChIRP-seq of three lncRNAs reveal that RNA occupancy sites in the genome are focal, sequence-specific, and numero... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21963238"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020411",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017421"
] |
5167d47e298dcd4e5100005e | summary | What is the use of MammaPrint and Oncotype DX? | [
"The MammaPrint and Oncotype DX assays are used to predict breast cancer recurrence risk and guide adjuvant chemotherapy decisions."
] | [] | [
"Molecular tests such as the 21 gene expression test (Oncotype DX(TM)) and 70 gene microarray test (MammaPrint(®)) have revolutionized the predictive and prognostic tools in the clinic. By stratifying the risk of recurrence for patients, the tests are able to provide clinicians with more information on the treatmen... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23573359",
"http://www.ncbi.nlm.nih.gov/pubmed/23411384",
"http://www.ncbi.nlm.nih.gov/pubmed/19101988",
"http://www.ncbi.nlm.nih.gov/pubmed/19585214",
"http://www.ncbi.nlm.nih.gov/pubmed/21998967",
"http://www.ncbi.nlm.nih.gov/pubmed/20587405",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A17680439",
"o": "MammaPrint"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#prefLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C2827401",
"o": "http://linkedlifedata.com/r... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D045506"
] |
56c313d150c68dd416000002 | yesno | Does nifedipine inhibit L-type calcium channels? | [
"Yes, nifedipine is a typical blocker of L-type calcium channels."
] | [
"yes"
] | [
"Nifedipine, an L-type calcium channel blocker, reduced the expression of synaptogamin and syntaxin and blocked the suppressive effect of vecuronium, suggesting that both agents inhibit presynaptic L-type calcium channels.",
"Treatment with nifedipine to inhibit calcium influx via the L-type channel Cav1.2 (alpha... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16573711",
"http://www.ncbi.nlm.nih.gov/pubmed/10320722",
"http://www.ncbi.nlm.nih.gov/pubmed/10404034",
"http://www.ncbi.nlm.nih.gov/pubmed/24752219",
"http://www.ncbi.nlm.nih.gov/pubmed/24513517",
"http://www.ncbi.nlm.nih.gov/pubmed/9388008",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4273755",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009543",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020746"
] |
54d76ac63706e89528000016 | yesno | Is there any data to suggest that TRH (thyrotropin releasing hormone) administration can improve symptom severity of amyotrophic lateral sclerosis patients? | [
"Yes, there are studies demonstrating that TRH (thyrotropin releasing hormone) administration can improve symptom severity of amyotrophic lateral sclerosis patients. However, some studies have failed to demonstrate symptom improvement following TRH administration.",
"Very high intravenous doses (2-19 mg/min) of t... | [
"yes"
] | [
"These central nervous system (CNS)-mediated effects provide the rationale for use of TRH and its analogs in the treatment of brain and spinal injury, and CNS disorders like schizophrenia, Alzheimer's disease, epilepsy, amyotrophic lateral sclerosis, Parkinson's disease, depression, shock and ischemia.",
"The Eff... | [
"http://www.ncbi.nlm.nih.gov/pubmed/3148185",
"http://www.ncbi.nlm.nih.gov/pubmed/3148186",
"http://www.ncbi.nlm.nih.gov/pubmed/2497684",
"http://www.ncbi.nlm.nih.gov/pubmed/2497685",
"http://www.ncbi.nlm.nih.gov/pubmed/3091628",
"http://www.ncbi.nlm.nih.gov/pubmed/2233870",
"http://www.ncbi.nlm.nih.gov... | [] | [
"http://www.biosemantics.org/jochem#4272308",
"http://www.disease-ontology.org/api/metadata/DOID:332"
] |
5709f646cf1c325851000021 | summary | How can DUF families be deciphered? | [
"The genome projects have unearthed an enormous diversity of genes of unknown function that are still awaiting biological and biochemical characterization. These genes, as most others, can be grouped into families based on sequence similarity. The PFAM database currently contains over 2,200 such families, referred ... | [] | [
" These families include proteins with domain of unknown function (DUF) DUF23, DUF246, and DUF266. The evidence for these proteins being GTs and their possible roles in cell wall biosynthesis is discussed.",
"The genome projects have unearthed an enormous diversity of genes of unknown function that are still awai... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22629278",
"http://www.ncbi.nlm.nih.gov/pubmed/24237627",
"http://www.ncbi.nlm.nih.gov/pubmed/23104832",
"http://www.ncbi.nlm.nih.gov/pubmed/24901469",
"http://www.ncbi.nlm.nih.gov/pubmed/25010333",
"http://www.ncbi.nlm.nih.gov/pubmed/19787035",
"http://www.ncbi.nlm.n... | [] | [] |
515c4f1f298dcd4e51000007 | list | Which genes does thyroid hormone receptor beta1 regulate in the heart? | [
"β-MHC, HCN4, KCND2/3, SERCA, TRbeta1, alpha-MHC"
] | [
"β-MHC",
"HCN4",
"KCND2/3",
"SERCA",
"TRbeta1",
"alpha-MHC"
] | [
"we identified thyroid hormone receptor β1 (TRβ1), which negatively regulates β-MHC transcription, as a target of miR-27a",
"HCN2 gene expression was not significantly affected by TR beta 1. TR beta 1 exclusively suppressed HCN4 transcription.",
"TRalpha1 increased I(to), while TRbeta1 significantly reduced I(t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19171649",
"http://www.ncbi.nlm.nih.gov/pubmed/21149577",
"http://www.ncbi.nlm.nih.gov/pubmed/9927321",
"http://www.ncbi.nlm.nih.gov/pubmed/19629520",
"http://www.ncbi.nlm.nih.gov/pubmed/11577024",
"http://www.ncbi.nlm.nih.gov/pubmed/17317766"
] | [] | [
"http://www.uniprot.org/uniprot/THB_PAROL"
] |
54297ed2289fd6cb07000001 | yesno | Can siRNA affect response to afatinib treatment? | [
"When afatinib was combined with an EGFR-specific siRNA there was a strong biological effect on growth inhibition and induction of apoptosis."
] | [
"yes"
] | [
"On the other hand, miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR, including both TKIs (gefitinib, erlotinib, and afatinib) and a monoclonal antibody (cetuximab)",
"These effects were independent of the EGFR mutation status (wild type, sensitizing mutation or resistance mutation),... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23555954",
"http://www.ncbi.nlm.nih.gov/pubmed/22436374",
"http://www.ncbi.nlm.nih.gov/pubmed/23266614"
] | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030422",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D034741",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090065"
] |
5325fdf0600967d132000001 | factoid | What is the gold standard treatment for Iatrogenic male incontinence? | [
"The artificial urethral sphincter has represented, until today, the gold standard but, in the recent years, sling systems have been investigated as minimally invasive alternative options."
] | [
"Artificial urethral sphincter",
"AUS"
] | [
"The initial treatment for SUI that persists after 12 months consists of conservative measures such as pelvic floor muscle exercises and behavioral therapy. Properly selected and informed patients can also be treated efficiently with minimally invasive procedures such as the implantation of a male suburethral sling... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19296976",
"http://www.ncbi.nlm.nih.gov/pubmed/17982750",
"http://www.ncbi.nlm.nih.gov/pubmed/20877609",
"http://www.ncbi.nlm.nih.gov/pubmed/23259418"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A10807588",
"o": "C50597"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#prefLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1708460",
"o": "http://linkedlifedata.com/resour... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014549",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013521",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053825",
"http://www.nlm.nih.gov/cgi/mesh/2... |
5357b36cf1005d6b58000006 | factoid | Which is the main CHEK2 genetic variant, thought to be involved in familial breast cancer? | [
"CHEK2 1100delC mutation is recurrently detected in the general population and is thought to confer a moderate risk for breast cancer."
] | [
"CHEK2 1100delC mutation"
] | [
"the two most studied breast cancer-predisposing variants of the CHEK2 gene, 1100delC and I157T",
"The CHEK2-1100delC mutation is recurrent in the population and is a moderate risk factor for breast cancer",
"The germline CHEK2-1100delC mutation was present among 8/1,646 (0.5%) sporadic, 2/400 (0.5%) early-onse... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16998506",
"http://www.ncbi.nlm.nih.gov/pubmed/17721994",
"http://www.ncbi.nlm.nih.gov/pubmed/12610780",
"http://www.ncbi.nlm.nih.gov/pubmed/14618615",
"http://www.ncbi.nlm.nih.gov/pubmed/19763819"
] | [] | [] |
54f49e56d0d681a040000004 | yesno | Is there an association between presenteeism and depression? | [
"Yes. Presenteeism is associated with depression. Remission of depression is associated with improvement of presenteeism."
] | [
"yes"
] | [
"Presenteeism was positively associated with severity of depression (Health and Work Performance Questionnaire, P < 0.0001; WPAI, P < 0.0001).",
"Statistically significant correlations (0.32-0.53) were found between presenteeism and increasing disability, fatigue, depression, anxiety, and reduced quality of life.... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15804203",
"http://www.ncbi.nlm.nih.gov/pubmed/21669372",
"http://www.ncbi.nlm.nih.gov/pubmed/14665817",
"http://www.ncbi.nlm.nih.gov/pubmed/20726684",
"http://www.ncbi.nlm.nih.gov/pubmed/25539872",
"http://www.ncbi.nlm.nih.gov/pubmed/25173795",
"http://www.ncbi.nlm.n... | [] | [] |
52f88d292059c6d71c000036 | list | Which hormone abnormalities are common in Williams syndrome | [
"Elevated Thyrotropin - TSH\nLow FT4\nGrowth Hormone deficiency\nCalcitonin deficiency\nElevated Prolactin\nElevated Cortisol\nElevated Oxytocin\nElevated Vasopressin"
] | [
"Elevated Thyrotropin -",
"Elevated TSH",
"Low FT4",
"Low Thyroxine",
"Growth Hormone deficiency",
"GHD",
"Calcitonin deficiency",
"Elevated Prolactin",
"Elevated Cortisol",
"Elevated Oxytocin",
"Elevated OT",
"Elevated Vasopressin",
"Elevated AVP"
] | [
"A girl with Williams syndrome (WS) presented with elevated thyrotropin (TSH) levels (7.0 microU/ml), normal free thyroid hormone concentrations, and absent antithyroid autoantibodies.",
"TSH response to thyrotropin-releasing hormone (TRH) injection (200 microg/mq, i.v.) was exaggerated and prolonged, suggesting ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23734615",
"http://www.ncbi.nlm.nih.gov/pubmed/18204753",
"http://www.ncbi.nlm.nih.gov/pubmed/22719898",
"http://www.ncbi.nlm.nih.gov/pubmed/10378390",
"http://www.ncbi.nlm.nih.gov/pubmed/15751610",
"http://www.ncbi.nlm.nih.gov/pubmed/16181239",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#subClassOf",
"s": "http://purl.uniprot.org/keywords/856",
"o": "http://purl.uniprot.org/keywords/9995"
},
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://purl.uniprot.org/keywords/856",
"o": "Williams-Beuren syndrome"
},
... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018980"
] |
5509ba931180f13250000001 | summary | What is the treatment of choice for gastric lymphoma? | [
"The treatment of choice for localized primary GI lymphoma is controversial. Complete surgical resection may increase the chance of complete remission, but mortality and relapse rates might be higher than those observed with combination chemotherapy alone.\nIn early stages of disease, H. pylori eradication alone ma... | [] | [
"The treatment of choice should be comprehensive therapy based on surgery.",
"The treatment of choice for localized primary GI lymphoma is controversial. Complete surgical resection may increase the chance of complete remission, but mortality and relapse rates might be higher than those observed with combination ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15213617",
"http://www.ncbi.nlm.nih.gov/pubmed/15672765",
"http://www.ncbi.nlm.nih.gov/pubmed/7975766",
"http://www.ncbi.nlm.nih.gov/pubmed/22368024",
"http://www.ncbi.nlm.nih.gov/pubmed/15916100",
"http://www.ncbi.nlm.nih.gov/pubmed/10796047",
"http://www.ncbi.nlm.ni... | [] | [] |
553f96191d53b76422000004 | list | Which assays can be used for detecting DNA fragmentation resulting from programmed cell death (apoptosis)? | [
"The biochemical hallmark of apoptosis is internucleosomal DNA cleavage into oligonucleosome-length fragments. Measurement of apoptosis-associated internucleosomal DNA fragmentation through determination of the percentage of fragmented DNA by electrophoresis or centrifugation of whole cell lysates is by far the mos... | [
"electrophoresis of whole cell lysates",
"centrifugation of whole cell lysates",
"terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling of DNA fragments (TUNEL)",
"in situ end labeling (ISEL) of the genomic DNA in fragmented nuclei",
"measurement of cytosolic histone-bound DNA fragmen... | [
"the biochemical hallmark of apoptosis is internucleosomal DNA cleavage into oligonucleosome-length fragments.",
" terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling of DNA fragments (TUNEL) and in situ end labeling (ISEL) techniques",
"TUNEL labeling of DNA fragments",
"Apoptotic ce... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10623423",
"http://www.ncbi.nlm.nih.gov/pubmed/10069565",
"http://www.ncbi.nlm.nih.gov/pubmed/18265108",
"http://www.ncbi.nlm.nih.gov/pubmed/1657218",
"http://www.ncbi.nlm.nih.gov/pubmed/16839211",
"http://www.ncbi.nlm.nih.gov/pubmed/7604973",
"http://www.ncbi.nlm.nih... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012501",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006915",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006309"
] |
517a8a718ed59a060a00003e | yesno | Does triiodothyronine stimulate red blood cell sodium potassium pump? | [
"An inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels.\nThe effect of triiodothyronine (T3) on Na+,K(+)-ATPase activity in red blood cells may be different in vivo and in vitro."
] | [
"no"
] | [
"reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels.",
"The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes.",
"at h... | [
"http://www.ncbi.nlm.nih.gov/pubmed/1333560",
"http://www.ncbi.nlm.nih.gov/pubmed/2987290",
"http://www.ncbi.nlm.nih.gov/pubmed/9781620"
] | [] | [] |
530f900ee3eabad021000003 | factoid | Which hormone concentrations are altered in patients with the Allan–Herndon–Dudley syndrome? | [
"Thyroid hormone concentrations are altered in patients with the Allan-Herndon-Dudley syndrome. In particular, high serum T3 levels and low-normal to low T4 serum levels are common in the Allan-Herndon-Dudley syndrome. It is, an X linked condition, is characterized by severe intellectual disability, dysarthria, ath... | [
"Thyroid"
] | [
"This syndrome is characterized by axial hypotonia, severe mental retardation, dysarthria, athetoid movements, spastic paraplegia, and a typical thyroid hormone profile. ",
"Our case and the review of the pertinent literature suggest that Allan-Herndon-Dudley syndrome should be suspected in males with the typical... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19936787",
"http://www.ncbi.nlm.nih.gov/pubmed/22543196",
"http://www.ncbi.nlm.nih.gov/pubmed/20435089",
"http://www.ncbi.nlm.nih.gov/pubmed/20713192",
"http://www.ncbi.nlm.nih.gov/pubmed/21896621",
"http://www.ncbi.nlm.nih.gov/pubmed/24268987",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A1702646",
"o": "21"
},
{
"p": "http://linkedlifedata.com/resource/umls/altMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C0795889",
"o": "http://linkedlifedata.com/reso... | [
"http://www.disease-ontology.org/api/metadata/DOID:0050631",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006728"
] |
56c1f00aef6e39474100003d | yesno | Is selumetinib effective in thyroid cancer? | [
"Yes, selumetinib was shown to be effective treatment for thyroid cancer. Selumetinib may reverse radioiodine uptake in patients with radioiodine-refractory differentiated thyroid cancer. Clinical efficacy of selumetinib was also investigated in other solid tumors."
] | [
"yes"
] | [
"A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours.",
"BACKGROUND: We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody)... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23435040",
"http://www.ncbi.nlm.nih.gov/pubmed/25268371",
"http://www.ncbi.nlm.nih.gov/pubmed/22451620",
"http://www.ncbi.nlm.nih.gov/pubmed/25294906",
"http://www.ncbi.nlm.nih.gov/pubmed/23406027",
"http://www.ncbi.nlm.nih.gov/pubmed/25240824",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:3963",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013964",
"http://www.disease-ontology.org/api/metadata/DOID:1781"
] |
54e8c7220fc566b149000002 | factoid | Where in the cell does the proteins S100A4 and p53 interact ? | [
"S100A4 interacts with p53 in the cell nucleus."
] | [
"nucleus"
] | [
"S100A4 interacts with p53 in the nucleus",
"we show that endogenous S100A4 and p53 interact in complex samples",
"using proximity ligation assay, we show that the interaction takes place in the cell nucleus.",
"Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mut... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20591429",
"http://www.ncbi.nlm.nih.gov/pubmed/16360031",
"http://www.ncbi.nlm.nih.gov/pubmed/17504119",
"http://www.ncbi.nlm.nih.gov/pubmed/23752197",
"http://www.ncbi.nlm.nih.gov/pubmed/19819244",
"http://www.ncbi.nlm.nih.gov/pubmed/17497677",
"http://www.ncbi.nlm.n... | [
{
"p": "http://linkedlifedata.com/resource/pubmed/registryNumber",
"s": "http://linkedlifedata.com/resource/pubmed/chemical/S100A4+protein%2C+human",
"o": "142662-27-9"
},
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/pubmed/chemical/S100A4+pro... | [
"http://www.uniprot.org/uniprot/P53_MACFU",
"http://www.uniprot.org/uniprot/S10A4_BOVIN",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002039",
"http://www.uniprot.org/uniprot/S10A4_HUMAN",
"http://www.uniprot.org/uniprot/P53_CANFA",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field... |
5325a1a69b2d7acc7e000025 | summary | What are the applications of a Dermaroller ? | [
"Microneedling with dermaroller is a new treatment modality for the treatment of scars, especially acne scars, stretch marks, wrinkles, and for facial rejuvenation. It is a simple and relatively cheap modality that also can be used for transdermal drug delivery.\nMicroneedling is a safe and a promising tool in hair... | [] | [
"Dermaroller along with Minoxidil treated group was statistically superior to Minoxidil treated group in promoting hair growth in men with AGA for all 3 primary efficacy measures of hair growth. Microneedling is a safe and a promising tool in hair stimulation and also is useful to treat hair loss refractory to Mino... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23960389",
"http://www.ncbi.nlm.nih.gov/pubmed/20808602",
"http://www.ncbi.nlm.nih.gov/pubmed/20300368"
] | [] | [] |
56cae51f5795f9a73e000025 | yesno | Are immune cells affected in Amyotrophic Lateral Sclerosis? | [
"In ALS T-cell deficiency increases neuronal loss, while boosting T cell levels reduces it.",
"The intrathymic injection of donor spleen cells into antilymphocyte serum (ALS)-treated mice induces significant prolongation of donor skin grafts. To elucidate possible mechanisms involved in the induction of unrespons... | [
"yes"
] | [
"Therapeutic immunization of mSOD1 mice with a myelin-derived peptide led to CP activation, and was followed by the accumulation of immunoregulatory cells, including IL-10-producing monocyte-derived macrophages and Foxp3(+) regulatory T cells, and elevation of the neurotrophic factors IGF-1 and GDNF in the diseased... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17852013",
"http://www.ncbi.nlm.nih.gov/pubmed/7595631",
"http://www.ncbi.nlm.nih.gov/pubmed/23881705",
"http://www.ncbi.nlm.nih.gov/pubmed/21829620",
"http://www.ncbi.nlm.nih.gov/pubmed/25199710",
"http://www.ncbi.nlm.nih.gov/pubmed/7551976",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000690",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012598",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002477",
"http://www.disease-ontology.org/a... |
571e3e2abb137a4b0c000008 | yesno | Are OATP1B1 and OATP1B3 associated with bilirubin transport? | [
"Yes, OATP1B1 and OATP1B3 are involved in the transport of bilirubin."
] | [
"yes"
] | [
"OATP1B1 and OATP1B3-mediated transport of bilirubin was confirmed and inhibition was determined for atazanavir, rifampicin, indinavir, amprenavir, cyclosporine, rifamycin SV and saquinavir. ",
"Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconju... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24523126",
"http://www.ncbi.nlm.nih.gov/pubmed/22232210",
"http://www.ncbi.nlm.nih.gov/pubmed/23695864",
"http://www.ncbi.nlm.nih.gov/pubmed/15535988",
"http://www.ncbi.nlm.nih.gov/pubmed/24459177",
"http://www.ncbi.nlm.nih.gov/pubmed/24151358",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001663",
"http://amigo.geneontology.org/amigo/term/GO:0015723",
"http://www.biosemantics.org/jochem#4274830"
] |
54f1e4d0c409818c32000002 | summary | What is the mechanism of action of eprotirome? | [
"Eprotirome belongs to thyromimetics and has selective TRβ1 activity. It has shown to be effective in dyslipidemia by the lipid-lowering action of TH in the liver and also in obesity."
] | [] | [
"Eprotirome and Sobetirome are 2 thyromimetics that have selective TRβ1 activity. ",
"Recently, the development of the most promising agent in this class, eprotirome, was halted over toxicology concerns following long-term canine studies. Consequently, the future of contemporary TRβ agonists is unclear. ",
"We ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22784847",
"http://www.ncbi.nlm.nih.gov/pubmed/22542282",
"http://www.ncbi.nlm.nih.gov/pubmed/24440706",
"http://www.ncbi.nlm.nih.gov/pubmed/23776891",
"http://www.ncbi.nlm.nih.gov/pubmed/23565368",
"http://www.ncbi.nlm.nih.gov/pubmed/20872316",
"http://www.ncbi.nlm.n... | [] | [] |
56bf5b0cef6e394741000014 | summary | What is the role of music therapy in coma patients. | [
"Several studies have shown that music can boost cognitive functions in patients with a disorder of consciousness but it is difficult to conclude since they did not use quantified measures and a control condition/group. Active improvised music therapy may offer an adjuvant form of treatment in the early rehabilitat... | [] | [
"[Beneficial effect of preferred music on cognitive functions in minimally conscious state patients].",
"Several studies have shown that music can boost cognitive functions in normal and brain-damaged subjects. A few studies have suggested a beneficial effect of music in patients with a disorder of consciousness ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7513085",
"http://www.ncbi.nlm.nih.gov/pubmed/12046234",
"http://www.ncbi.nlm.nih.gov/pubmed/25071434",
"http://www.ncbi.nlm.nih.gov/pubmed/25287735",
"http://www.ncbi.nlm.nih.gov/pubmed/20663643",
"http://www.ncbi.nlm.nih.gov/pubmed/23816631"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009147",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003128"
] |
517194ef8ed59a060a000011 | factoid | Which is the causative agent of malaria? | [
"Four Plasmodium species commonly infect humans (Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale). Plasmodium falciparum infects about 5-10% of the world human population per year and it is the causative agent of the most severe and lethal form of malaria. P. falciparum causes fat... | [
"Plasmodium species",
"Plasmodium spp."
] | [
"lasmodium falciparum the main causative agent of malaria is an important public health vector.",
"Plasmodium falciparum the main causative agent of malaria is an important public health vector. <",
"Overcoming antigenic variation is one of the major challenges in the development of an effective vaccine against... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12930149",
"http://www.ncbi.nlm.nih.gov/pubmed/15003844",
"http://www.ncbi.nlm.nih.gov/pubmed/15117937",
"http://www.ncbi.nlm.nih.gov/pubmed/19184366",
"http://www.ncbi.nlm.nih.gov/pubmed/20635416",
"http://www.ncbi.nlm.nih.gov/pubmed/14556002",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/710",
"o": "Malaria"
},
{
"p": "http://linkedlifedata.com/resource/umls/altMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C0024530",
"o": "http://linkedlifed... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008288",
"http://www.disease-ontology.org/api/metadata/DOID:12978",
"http://www.disease-ontology.org/api/metadata/DOID:14067",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010965",
"http:... |
53551206a0726bee57000001 | factoid | What is the major adverse effect of adriamycin(doxorubicin)? | [
"Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy ",
"Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy. In spite of the routine use of this drug its major adverse effect, the dose-dependent cardiotoxicity, cannot be prevented yet. Cardiotoxicity is a ma... | [
"Cardiotoxicity",
"Cardiac toxicity"
] | [
"It remains to be seen whether inhibition by adriamycin of these systems is related to the severe cardiotoxicity, the major adverse effect of the drug that limits its clinical usefulness.",
"Leukocytopenia was the major adverse effect among patients undergoing systemic THP administration",
"The major adverse ef... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15997091",
"http://www.ncbi.nlm.nih.gov/pubmed/21295102",
"http://www.ncbi.nlm.nih.gov/pubmed/3947104",
"http://www.ncbi.nlm.nih.gov/pubmed/12074691",
"http://www.ncbi.nlm.nih.gov/pubmed/15114698",
"http://www.ncbi.nlm.nih.gov/pubmed/3459397",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.biosemantics.org/jochem#4269440",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004317"
] |
56c3104c50c68dd416000001 | summary | What is GDF10? | [
"The growth/differentiation factor-10 (GDF-10) is a new member of the transforming growth factor-beta (TGF-beta) superfamily. It is highly related to bone morphogenetic protein-3 (BMP-3) and often referred to as BMP3b. The nucleotide sequence of GDF-10 encodes a predicted protein of 476 amino acids with a molecular... | [] | [
"We have identified a new member of the transforming growth factor-beta (TGF-beta) superfamily, growth/differentiation factor-10 (GDF-10), which is highly related to bone morphogenetic protein-3 (BMP-3). The nucleotide sequence of GDF-10 encodes a predicted protein of 476 amino acids with a molecular weight of appr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8679252",
"http://www.ncbi.nlm.nih.gov/pubmed/24963847",
"http://www.ncbi.nlm.nih.gov/pubmed/8670277"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055413",
"http://www.uniprot.org/uniprot/GDF10_BOVIN",
"http://www.uniprot.org/uniprot/GDF10_HUMAN"
] |
531b4269b166e2b80600003e | yesno | Is thyroid hormone therapy indicated in patients with heart failure? | [
"There are several experimental and clinical evidences of the potential benefits of Thyroid hormone replacement therapy in heart failure. Initial clinical data showed also a good safety profile and tolerance of TH replacement therapy in patients withheart failure. \nHowever currently there is no indication to treat... | [
"no"
] | [
"Patients with chronic heart failure and subclinical hypothyroidism significantly improved their physical performance when normal TSH levels were reached.",
"Early and sustained physiological restoration of circulating L-T3 levels after MI halves infarct scar size and prevents the progression towards heart failur... | [
"http://www.ncbi.nlm.nih.gov/pubmed/2189307",
"http://www.ncbi.nlm.nih.gov/pubmed/18171701",
"http://www.ncbi.nlm.nih.gov/pubmed/17710084",
"http://www.ncbi.nlm.nih.gov/pubmed/9485134",
"http://www.ncbi.nlm.nih.gov/pubmed/23660007",
"http://www.ncbi.nlm.nih.gov/pubmed/8936682",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013963",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020249",
"http://www.disease-ontology.org/api/metadata/DOID:6000",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Ex... |
54edf05494afd6150400000e | yesno | Is there a mouse model for Fanconi anemia? | [
"A number of mouse models have already been generated with a targeted disruption of several Fanconi anemia genes, such as FANCA, FANCF, FANCM, FANCD1, etc."
] | [
"yes"
] | [
"Cyclophosphamide promotes engraftment of gene-modified cells in a mouse model of Fanconi anemia without causing cytogenetic abnormalities",
"We compared Cy preconditioning with fludarabine (Flu) or cytarabine (AraC) or no conditioning as a control in fanca ( -/- ) mutant mice receiving gene-modified bone marrow ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10936049",
"http://www.ncbi.nlm.nih.gov/pubmed/12135664",
"http://www.ncbi.nlm.nih.gov/pubmed/12200363",
"http://www.ncbi.nlm.nih.gov/pubmed/16859999",
"http://www.ncbi.nlm.nih.gov/pubmed/21240276",
"http://www.ncbi.nlm.nih.gov/pubmed/19561169",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051856",
"http://www.disease-ontology.org/api/metadata/DOID:13636",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005199",
"http://www.disease-ontology.org/api/metadata/DOID:1062"
] |
553fb11fc6a5098552000003 | yesno | Could Hyperthermic intraperitoneal chemotherapy (HIPEC) be effective for the treatment of recurrent ovarian cancer? | [
"There is level-one evidence suggesting the benefit of postoperative adjuvant intraperitoneal chemotherapy for patients with advanced ovarian cancer after cytoreductive surgery, albeit catheter-related complications resulted after treatment discontinuation. Studies report the use of HIPEC predominantly in the setti... | [
"yes"
] | [
"The use of HIPEC after aggressive cytoreductive surgery in patients with ovarian cancer with peritoneal dissemination can be performed with acceptable postoperative morbidity rates. Knowledge of the factors associated with the onset of these postoperative adverse events allows better management of the same and off... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24035502",
"http://www.ncbi.nlm.nih.gov/pubmed/22591422",
"http://www.ncbi.nlm.nih.gov/pubmed/20039210",
"http://www.ncbi.nlm.nih.gov/pubmed/19345401",
"http://www.ncbi.nlm.nih.gov/pubmed/21842290",
"http://www.ncbi.nlm.nih.gov/pubmed/19948452",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010051",
"http://www.disease-ontology.org/api/metadata/DOID:2394"
] |
56ffdc1ccf1c32585100000b | factoid | Which is the most common editing modification in eukaryotic mRNA? | [
"One of the most common forms of pre-mRNA editing is A-to-I editing, in which adenosine is deaminated to inosine, which is read as guanosine during translation."
] | [
"A-to-I"
] | [
"One of the most common forms of pre-mRNA editing is A-to-I editing, in which adenosine is deaminated to inosine, which is read as guanosine during translation.",
"Deamination of adenine by adenosine deaminases that act on RNA (ADARs) leads to the conversion of adenine into inosine (A-I editing) recognized by the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20198873",
"http://www.ncbi.nlm.nih.gov/pubmed/25577380",
"http://www.ncbi.nlm.nih.gov/pubmed/23543219",
"http://www.ncbi.nlm.nih.gov/pubmed/21469143",
"http://www.ncbi.nlm.nih.gov/pubmed/23346095",
"http://www.ncbi.nlm.nih.gov/pubmed/20185571",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012333",
"http://amigo.geneontology.org/amigo/term/GO:0016556",
"http://amigo.geneontology.org/amigo/term/GO:0009451",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017393"
] |
5319abc9b166e2b80600002d | yesno | Is Rac1 involved in cancer cell invasion? | [
"A number of signalling pathways have been found to converge to and activate Rac1, which, in turn, activates a number of downstream targets to control actin-cytoskeleton rearrangements at membrane ruffles, as well as formation and activity of lamellipodia, to regulate the migratory processes leading to cell invasio... | [
"yes"
] | [
"In the Matrigel invasion assay, knockdown of CCR1 and inhibition of the ERK and Rac signaling pathways significantly decreased the number of invading cells.",
"These results demonstrated for the first time that the interaction of CCR1 with CCL5 caused by increased expression of CCR1 promotes invasion of PC3PR ce... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20001211",
"http://www.ncbi.nlm.nih.gov/pubmed/23242308",
"http://www.ncbi.nlm.nih.gov/pubmed/21377450",
"http://www.ncbi.nlm.nih.gov/pubmed/23554696",
"http://www.ncbi.nlm.nih.gov/pubmed/22161837",
"http://www.ncbi.nlm.nih.gov/pubmed/20307526",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020830",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009361",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009369",
"http://www.uniprot.org/uniprot/RA... |
54de15f91388e8454a000002 | list | Which are the APOBEC3 protein family members able to inhibit Vif-deficient HIV-1 replication? | [
"APOBEC3G, APOBEC3F, APOBEC3DE, APOBEC3A, and APOBEC3H haplotypes II, V, and VII, provide protection against Vif-deficient HIV-1, through hypermutation of the viral genome, inhibition of reverse transcription, and inhibition of viral DNA integration into the host genome."
] | [
"APOBEC3G",
"APOBEC3F",
"APOBEC3DE",
"APOBEC3A",
"APOBEC3H haplotypes II, V, and VII"
] | [
"APOBEC3DE, APOBEC3F, APOBEC3G, and APOBEC3H haplotypes II, V, and VII provide protection against HIV-1Δvif through hypermutation of the viral genome, inhibition of reverse transcription, and inhibition of viral DNA integration into the host genome",
"low quantities of IFN-α failed to upregulate costimulatory mol... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21279453",
"http://www.ncbi.nlm.nih.gov/pubmed/15466872",
"http://www.ncbi.nlm.nih.gov/pubmed/21835787",
"http://www.ncbi.nlm.nih.gov/pubmed/23316055",
"http://www.ncbi.nlm.nih.gov/pubmed/22787460",
"http://www.ncbi.nlm.nih.gov/pubmed/18495196",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/ABEC3_MOUSE",
"http://www.uniprot.org/uniprot/ABEC3_CRILO",
"http://www.uniprot.org/uniprot/ABEC3_RAT"
] |
56d8ba1851531f7e33000005 | yesno | Is the gene SLC6A2 associated with orthostatic intolerance? | [
"Yes, variants of the SLC6A2 (or NET) gene are associated with orthostatic intolerance."
] | [
"yes"
] | [
"Orthostatic intolerance is a debilitating syndrome characterized by tachycardia on assumption of upright posture. The norepinephrine (NE) transporter (NET) has been implicated in a genetic form of the disorder. ",
"Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthosta... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23580201",
"http://www.ncbi.nlm.nih.gov/pubmed/12589229",
"http://www.ncbi.nlm.nih.gov/pubmed/22723437",
"http://www.ncbi.nlm.nih.gov/pubmed/11458707",
"http://www.ncbi.nlm.nih.gov/pubmed/12391111",
"http://www.ncbi.nlm.nih.gov/pubmed/15894713",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054971"
] |
5172e9448ed59a060a000018 | summary | Other than protein coding potential, what features set apart long non-coding RNAs from protein coding genes? | [
"Compared to protein coding genes, long non-coding RNAs (lncRNAs) display a bias towards two-exon transcripts. They are predominantly localized in the chromatin and nucleous. They are lower expressed and display a more tissue-specific expression pattern. LncRNAs are overall more weakly conserved than protein coding... | [] | [
"Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths.",
"In contrast to protein-coding genes, however, lncRNAs display a striking bias toward two-exon transcripts",
"hey a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21502407",
"http://www.ncbi.nlm.nih.gov/pubmed/22303401",
"http://www.ncbi.nlm.nih.gov/pubmed/23274483",
"http://www.ncbi.nlm.nih.gov/pubmed/19895688",
"http://www.ncbi.nlm.nih.gov/pubmed/21112873",
"http://www.ncbi.nlm.nih.gov/pubmed/22955988",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D022661",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062085"
] |
56c863385795f9a73e000015 | yesno | Is macitentan an ET agonist? | [
"No, macitentan is anendothelin receptor antagonist."
] | [
"no"
] | [
"Administration of an ET receptor antagonist, either bosentan or macitentan, markedly attenuated PD-induced MMT, fibrosis, angiogenesis, and peritoneal functional decline. ",
"Macitentan is an oral, once-daily, dual endothelin (ET)A and ETB receptor antagonist with high affinity and sustained receptor binding tha... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23830395",
"http://www.ncbi.nlm.nih.gov/pubmed/22862294",
"http://www.ncbi.nlm.nih.gov/pubmed/18780830",
"http://www.ncbi.nlm.nih.gov/pubmed/25539851",
"http://www.ncbi.nlm.nih.gov/pubmed/24797866",
"http://www.ncbi.nlm.nih.gov/pubmed/23984728",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D065128",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D065131",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D065130"
] |
530b4f49970c65fa6b00000a | yesno | Can we use platelet biomarkers to study Alzheimer's disease? | [
"Yes, platelet biomarkers can be used to study Alzheimer's disease."
] | [
"yes"
] | [
"Platelet biomarkers in Alzheimer's disease.",
"platelets are the most important source of circulating forms of the amyloid precursor protein and other important proteins such as Tau and glycogen synthase kinase-3B.",
"Alternative plasma and platelet measures are described,",
"The success of these studies led... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22579745",
"http://www.ncbi.nlm.nih.gov/pubmed/24175175",
"http://www.ncbi.nlm.nih.gov/pubmed/22674539"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015415",
"http://www.disease-ontology.org/api/metadata/DOID:10652",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000544"
] |
5306158358348c0f52000001 | list | Which genetic defects are observed in Prader-Willi syndrome? | [
"The predominant genetic defects in Prader-Willi syndrome are 15q11-13 deletions of paternal origin and maternal chromosome 15 uniparental disomy, or rare imprinting mutations, combined with monoallelic expression of the paternal alleles."
] | [
"15q11-13 deletions of paternal origin",
"maternal chromosome 15 uniparental disomy",
"rare imprinting mutations",
"monoallelic expression of the paternal alleles"
] | [
"Prader-Willi syndrome is a complex genetic disease caused by lack of expression of paternally inherited genes on chromosome 15q11-q13.",
"Prader-Willi syndrome (PWS) is caused by the disturbed expression of genes from the imprinted region of 15q11-q13, but the specific contributions of individual genes remain un... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9629378",
"http://www.ncbi.nlm.nih.gov/pubmed/9613204",
"http://www.ncbi.nlm.nih.gov/pubmed/1608955",
"http://www.ncbi.nlm.nih.gov/pubmed/14749005",
"http://www.ncbi.nlm.nih.gov/pubmed/21798057",
"http://www.ncbi.nlm.nih.gov/pubmed/18627056",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:11983",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071514",
"http://www.disease-ontology.org/api/metadata/DOID:0050325",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011218",
"http://www.nlm.nih.... |
56cae3eb5795f9a73e000021 | factoid | What is the most likely age of diagnosis of Crohn's disease (CD)? | [
"Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. When the age-related incidence of Crohn's disease was plotted for all countrie... | [
"Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals."
] | [
"Eighteen, 17, and 12 patients were diagnosed at ages<40, 40-59, and ≥60 years, respectively",
"Crohn's disease (CD) diagnosed in pediatric patients has been reported to have a more aggressive phenotype and course, with a greater prevalence of upper gastrointestinal involvement, than in adults.",
"There was a s... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22685044",
"http://www.ncbi.nlm.nih.gov/pubmed/9412954",
"http://www.ncbi.nlm.nih.gov/pubmed/18236809",
"http://www.ncbi.nlm.nih.gov/pubmed/23880115",
"http://www.ncbi.nlm.nih.gov/pubmed/23511037",
"http://www.ncbi.nlm.nih.gov/pubmed/19107777",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003424",
"http://www.disease-ontology.org/api/metadata/DOID:4"
] |
51682c52298dcd4e51000067 | summary | How does thyroid hormone affect insulin resistance in the heart? | [
"T3 potentiates insulin signaling and improves insulin sensitivity. In addition, T3 lowers blood glucose in a model of type 2 diabetes. TRalpha P398H mutation is associated with insulin resistance. Circulating T(1)AM is produced from thyroid hormones and is found to be increased in diabetic patients."
] | [] | [
"In diabetic vs. nondiabetic patients T(1)AM concentration was significantly increased (0.232 ± 0.014 vs. 0.203 ± 0.006 pmol/ml, P = 0.044),",
"Our results are consistent with the hypothesis that circulating T(1)AM is produced from thyroid hormones and encourage further investigations on the potential role of T(1... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12869545",
"http://www.ncbi.nlm.nih.gov/pubmed/20883475",
"http://www.ncbi.nlm.nih.gov/pubmed/22031514"
] | [] | [
"http://www.uniprot.org/uniprot/THB_HUMAN",
"http://www.uniprot.org/uniprot/THB_SHEEP",
"http://www.uniprot.org/uniprot/THA_MOUSE",
"http://www.uniprot.org/uniprot/THA_PYGAD",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013963",
"http://www.uniprot.org/uniprot/THA_AP... |
5149af96d24251bc05000046 | list | Which are the state-of-the-art computational tools for the prediction of gene fusion events? | [
"Gene fusion detection - also known as the 'Rosetta Stone' method - involves the identification of fused composite genes in a set of reference genomes, which indicates potential interactions between its un-fused counterpart genes in query genomes. A few methods/tools and computational pipelines for the detection of... | [
"fdfBLAST",
"FusionDB",
"InPrePPI",
"Integrated method for Prediction of Protein-Protein Interactions",
"MosaicFinder",
"Phydbac2",
"PLEX",
"Predictome",
"Rosetta Stone method",
"STRING"
] | [
"MosaicFinder: Identification of fused gene families in sequence similarity networks",
"This leads to an efficient formulation of previous methods of fused gene identification, which we implemented in the Python program FusedTriplets.",
"We implemented this method in the C++ program MosaicFinder, which addition... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12519996",
"http://www.ncbi.nlm.nih.gov/pubmed/10573422",
"http://www.ncbi.nlm.nih.gov/pubmed/11820254",
"http://www.ncbi.nlm.nih.gov/pubmed/15701682",
"http://www.ncbi.nlm.nih.gov/pubmed/18025684",
"http://www.ncbi.nlm.nih.gov/pubmed/18949021",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A10835131",
"o": "Gene Fusion"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0178648",
"o": "http://linkedlifedata.com/r... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D058977",
"http://www.uniprot.org/uniprot/V55_BPT7",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012984",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D... |
53175e25b166e2b806000007 | yesno | Is CHEK2 involved in cell cycle control? | [
"CHEK2 is a key cell cycle control gene encoding a pluripotent kinase that can cause arrest or apoptosis in response to unrepaired DNA damage."
] | [
"yes"
] | [
"Moreover, cell-cycle progression genes [i.e. E2F transcription factor (E2F) family and histone deacetylase ( HDAC )] and DNA-repair genes [i.e. growth arrest and DNA-damage-inducible, gamma ( GADD45G ) family and serine/threonine-protein kinase Chk2 ( CHEK2)] were also increased.",
"As CHEK2 is a cell-cycle mast... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17517688",
"http://www.ncbi.nlm.nih.gov/pubmed/16596250",
"http://www.ncbi.nlm.nih.gov/pubmed/21956126",
"http://www.ncbi.nlm.nih.gov/pubmed/11751432",
"http://www.ncbi.nlm.nih.gov/pubmed/23030661",
"http://www.ncbi.nlm.nih.gov/pubmed/18024013",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000075",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071850",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D059447",
"http://www.uniprot.org/uniprot/CHK2_HUMAN",
"http://www.nlm.nih... |
56c07ef5ef6e394741000023 | summary | Describe mechanism of action of PLX3397 drug. | [
"PLX3397 works by inhibiting colony-stimulating-factor-1 receptor (CSF1R)."
] | [] | [
"Following the 25 d lesion, we administered PLX3397, a CSF1R inhibitor, for 30 d to eliminate microglia. ",
".METHODS: Using x-ray co-crystallography to guide our drug-discovery research, we generated a potent, selective CSF1R inhibitor, PLX3397, that traps the kinase in the autoinhibited conformation.",
"Treat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24718867",
"http://www.ncbi.nlm.nih.gov/pubmed/24247719",
"http://www.ncbi.nlm.nih.gov/pubmed/25110953",
"http://www.ncbi.nlm.nih.gov/pubmed/26222558",
"http://www.ncbi.nlm.nih.gov/pubmed/25042473",
"http://www.ncbi.nlm.nih.gov/pubmed/26156998",
"http://www.ncbi.nlm.n... | [] | [] |
5509bd6a1180f13250000002 | factoid | What disease is small bowel lymphoma commonly associated with | [
"Small bowel lymphoma is commonly associated with celiac disease."
] | [
"Celiac disease",
"gluten-associated enteropathy",
"CELIAC SPRU",
"Non tropical spru",
"Gluten Sensitive Enteropath"
] | [
"Marginal zone B-cell lymphoma of MALT in small intestine associated with amyloidosis: a rare association.",
"This is the first case of marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) in the small intestine associated with amyloidosis in Korea",
"MR enterography of small-bowel lymphoma... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21532863",
"http://www.ncbi.nlm.nih.gov/pubmed/12002682",
"http://www.ncbi.nlm.nih.gov/pubmed/10912475",
"http://www.ncbi.nlm.nih.gov/pubmed/18212211"
] | [] | [] |
530c7fa4970c65fa6b000012 | yesno | Are the proteins Erbin (LAP2) and Merlin cooperating? | [
"Yes, Erbin and Merlin are cooperating."
] | [
"yes"
] | [
"Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta.",
"The results show that the epithelial-enriched protein Erbin controls the function of the NF2 tumor suppressor Merlin by determining the output of Merlin's physical interactions with active PAK2.... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15659388",
"http://www.ncbi.nlm.nih.gov/pubmed/19289088"
] | [] | [
"http://www.uniprot.org/uniprot/MERL_RAT",
"http://www.uniprot.org/uniprot/MERL_PAPAN",
"http://www.uniprot.org/uniprot/MERL_MOUSE",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D025581",
"http://www.uniprot.org/uniprot/LAP2_HUMAN",
"http://www.biosemantics.org/jochem#... |
54e0d7471388e8454a000015 | factoid | Which molecule is targeted by a monoclonal antibody Secukinumab? | [
"Secukinumab (AIN457) is a fully human anti-interleukin-17A monoclonal antibody that neutralizes interleukin-17A."
] | [
"interleukin-17A"
] | [
"We identified 3 distinct clonotypes that efficiently neutralized IL17A in a cell-based in vitro assay. Their potencies were comparable to those of known neutralizing antibodies, including 2, AIN457 (secukinumab) and ixekizumab that are currently in clinical development for the treatment of various inflammatory dis... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22875601",
"http://www.ncbi.nlm.nih.gov/pubmed/22595313",
"http://www.ncbi.nlm.nih.gov/pubmed/23730881",
"http://www.ncbi.nlm.nih.gov/pubmed/25132411",
"http://www.ncbi.nlm.nih.gov/pubmed/23858337",
"http://www.ncbi.nlm.nih.gov/pubmed/24157091",
"http://www.ncbi.nlm.n... | [] | [] |
54f9c40ddd3fc62544000001 | factoid | Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)? | [
"The activity of NFAT proteins is tightly regulated by the Ca(2+)/calmodulin-dependent protein phosphatase 2B/calcineurin (CaN).Dephosphorylation of NFAT by CaN is required for NFAT nuclear localization."
] | [
"Calcineurin",
"CaN",
"phosphatase 2b"
] | [
"Transcription downstream of Ca(2+) influx is in large part funneled through the transcription factor nuclear factor of activated T cells (NFAT), a heavily phosphorylated protein that is cytoplasmic in resting cells, but that enters the nucleus when dephosphorylated by the calmodulin-dependent serine/threonine phos... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17572487",
"http://www.ncbi.nlm.nih.gov/pubmed/10593895",
"http://www.ncbi.nlm.nih.gov/pubmed/17099778",
"http://www.ncbi.nlm.nih.gov/pubmed/9374467",
"http://www.ncbi.nlm.nih.gov/pubmed/16260608",
"http://www.ncbi.nlm.nih.gov/pubmed/18005668",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D050778",
"http://www.uniprot.org/uniprot/CALM_ELEEL"
] |
515debe7298dcd4e51000026 | yesno | Is abdominal pain a common symptom in autism? | [
"Yes, although there are no precise data. There is data that Lactase deficiency, not associated with intestinal inflammation or injury, is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior."
] | [
"yes"
] | [
"Participants included 132 children with ASD and 81 with special educational needs (SEN) but no ASD, aged 10-14 years plus 82 typically developing (TD) children",
"The ASD group had significantly increased past vomiting and diarrhoea compared with the TD group and more abdominal pain than the SEN group",
"Many ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22997101",
"http://www.ncbi.nlm.nih.gov/pubmed/21415091",
"http://www.ncbi.nlm.nih.gov/pubmed/21114016",
"http://www.ncbi.nlm.nih.gov/pubmed/23371507",
"http://www.ncbi.nlm.nih.gov/pubmed/12846385",
"http://www.ncbi.nlm.nih.gov/pubmed/19329445",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015746",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001321"
] |
56f6ab7009dd18d46b00000d | yesno | Are cyclophilins ubiquitously expressed? | [
"Yes, \tcyps (cyclophilins) are ubiquitous proteins of the immunophilin superfamily."
] | [
"yes"
] | [
"Cyclophilin from Leishmania donovani (LdCyp) is a ubiquitous peptidyl-prolyl cis-trans isomerase",
"Cyclophilins (CYPs) and FK506-binding proteins (FKBPs) are ubiquitous proteins belonging to the peptidyl-prolyl cis/trans isomerase (PPIase) family.",
" However, their wide distribution and ubiquitous nature sig... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19403925",
"http://www.ncbi.nlm.nih.gov/pubmed/15869639",
"http://www.ncbi.nlm.nih.gov/pubmed/25259854",
"http://www.ncbi.nlm.nih.gov/pubmed/23849880",
"http://www.ncbi.nlm.nih.gov/pubmed/23123451",
"http://www.ncbi.nlm.nih.gov/pubmed/24887548",
"http://www.ncbi.nlm.n... | [] | [] |
56e5aeec0c19e5451d000002 | yesno | Are adenylyl cyclases always transmembrane proteins? | [
"Adenylyl cyclases exists both as transmembrane and soluble proteins."
] | [
"no"
] | [
"ransmembrane adenylyl cyclase",
" Transmembrane adenylyl cyclase (tmAC) and soluble AC (sAC) ",
"Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25010002",
"http://www.ncbi.nlm.nih.gov/pubmed/24980705",
"http://www.ncbi.nlm.nih.gov/pubmed/25073090",
"http://www.ncbi.nlm.nih.gov/pubmed/25009261",
"http://www.ncbi.nlm.nih.gov/pubmed/25350397",
"http://www.ncbi.nlm.nih.gov/pubmed/24574382",
"http://www.ncbi.nlm.n... | [] | [] |
532ff917d6d3ac6a34000038 | factoid | What histone trimethylation has been associated to RNA splicing? | [
"Mostly H3K36me3 but there is some evidence that H3K4me3 may also play a role in splicing"
] | [
"H3K36me3"
] | [
"histone H3 lysine 36 tri-methylation (H3K36Me3), exhibits different patterns around the cleavage sites of genes using multiple polyadenylation sites from those of genes using a single polyadenylation site.",
"ChIP-sequencing data mapped onto skipped exon events reveal a correlation between histone H3K36 trimethy... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23740743",
"http://www.ncbi.nlm.nih.gov/pubmed/18042460",
"http://www.ncbi.nlm.nih.gov/pubmed/22308494",
"http://www.ncbi.nlm.nih.gov/pubmed/21807997",
"http://www.ncbi.nlm.nih.gov/pubmed/23676078",
"http://www.ncbi.nlm.nih.gov/pubmed/19823040",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012326",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010452",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001253",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:... |
569e7721ceceede94d000001 | factoid | What was the purpose of the FANTOM4 project? | [
"The international Functional Annotation Of the Mammalian Genomes 4 (FANTOM4) research collaboration set out to better understand the transcriptional network that regulates macrophage differentiation and to uncover novel components of the transcriptome employing a series of high-throughput experiments."
] | [
"Better understand the transcriptional network that regulates macrophage differentiation"
] | [
"The international Functional Annotation Of the Mammalian Genomes 4 (FANTOM4) research collaboration set out to better understand the transcriptional network that regulates macrophage differentiation and to uncover novel components of the transcriptome employing a series of high-throughput experiments.",
"The int... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19377474",
"http://www.ncbi.nlm.nih.gov/pubmed/19374775",
"http://www.ncbi.nlm.nih.gov/pubmed/21075797"
] | [] | [] |
53302bced6d3ac6a34000039 | yesno | Does low T3 negatively affect prognosis of patients after cardiac surgery? | [
"Low cardiac output syndrome after cardiac surgery for congenital heart diseases is associated with decreased T3\nLow T3 concentrations are associated with occurrence of post operative atrial fibrillation\nLow T3 concentrations are inversely correlated with the days of post operative hospitalization"
] | [
"yes"
] | [
"ur findings suggest that the development of LCOS after congenital heart surgery is associated with decreased total and free T3, and increased IL-8 levels at 48 hours, and preoperative tT4 level is an independent predictor of LCOS.",
"Low basal fT3 concentration can reliably predict the occurrence of postoperativ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12475369",
"http://www.ncbi.nlm.nih.gov/pubmed/4057698",
"http://www.ncbi.nlm.nih.gov/pubmed/2627465",
"http://www.ncbi.nlm.nih.gov/pubmed/12165116",
"http://www.ncbi.nlm.nih.gov/pubmed/14500064",
"http://www.ncbi.nlm.nih.gov/pubmed/19448543",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011379",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013903",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013963",
"http://www.nlm.nih.gov/cgi/mesh/2... |
52f89a002059c6d71c00004c | summary | Which deficiency is the cause of restless leg syndrome | [
"Iron deficiency (low serum ferritin) is a recognized cause for RLS. Further, in the striatum of subjects with restless legs syndrome, the dopamine transporter is decreased, which leads to impaired dopaminergic neurotransmission. There is also a report of magnesium deficiency underlying RLS."
] | [] | [
"Homozygosity for the T-allele of BTBD9 rs9296249 was associated with lower serum ferritin",
"This polymorphism has previously been associated with RLS, but not low iron stores in blood donors.",
"Iron deficiency is a common cause of anemia in patients with end stage renal disease (ESRD). Intravenous iron admin... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19081645",
"http://www.ncbi.nlm.nih.gov/pubmed/19935988",
"http://www.ncbi.nlm.nih.gov/pubmed/8363978",
"http://www.ncbi.nlm.nih.gov/pubmed/18360657",
"http://www.ncbi.nlm.nih.gov/pubmed/20814842",
"http://www.ncbi.nlm.nih.gov/pubmed/19467991",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/diseaseontology/id/DOID:0050425",
"o": "MSH:D012148"
},
{
"p": "http://www.w3.org/2004/02/skos/core#prefLabel",
"s": "http://linkedlifedata.com/resource/diseaseontology/id/DOID:0050425",
"o": ... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012148"
] |
56e460d051531f7e33000019 | list | List the results of mutated casein kinase 1 epsilon. | [
"Mutation in casein kinase 1 epsilon results in a short circadian period, abnormal entrainment to light cycles, and potentiated resetting responses to light.\nMutations of CK1epsilon found in breast cancer can suppress Wnt/beta-catenin as well as promote the Wnt/Rac-1/JNK and Wnt/NFAT pathways, thus contributing to... | [
"short circadian period",
"abnormal entrainment to light cycles",
"potentiated resetting responses to light",
"REM sleep amount",
"NREM sleep architecture",
"effects on cell adhesion",
"effects on cell migration",
"timing of sleep"
] | [
"These results demonstrate a role for Csnk1e in regulating not only the timing of sleep, but also the REM sleep amount and NREM sleep architecture, and support Csnk1e as a causal gene in the sleep QTL on chromosome 15.",
"mutations of CK1epsilon found in breast cancer can suppress Wnt/beta-catenin as well as prom... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18522517",
"http://www.ncbi.nlm.nih.gov/pubmed/11076012",
"http://www.ncbi.nlm.nih.gov/pubmed/24744456",
"http://www.ncbi.nlm.nih.gov/pubmed/19142762",
"http://www.ncbi.nlm.nih.gov/pubmed/20507565"
] | [] | [] |
56c1d846ef6e39474100002e | yesno | Does neuroglobin has neuroprotective properties in the setting of traumatic brain injury? | [
"Yes, neuroglobin has neuroprotective properties in the setting of traumatic brain injury."
] | [
"yes"
] | [
"Neuroglobin has shown rich neuroprotective effects against cerebral hypoxia, and therefore has the potential to impact outcomes after traumatic brain injury (TBI). ",
"Neuroglobin (Ngb) is proposed to be a neuron-specific, hypoxia-responsive, neuroprotective protein. ",
"CONCLUSION: The increased expression of... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23658829",
"http://www.ncbi.nlm.nih.gov/pubmed/24491879",
"http://www.ncbi.nlm.nih.gov/pubmed/20345238",
"http://www.ncbi.nlm.nih.gov/pubmed/20476562",
"http://www.ncbi.nlm.nih.gov/pubmed/20544857",
"http://www.ncbi.nlm.nih.gov/pubmed/25624825",
"http://www.ncbi.nlm.n... | [] | [] |
5156be04d24251bc05000085 | factoid | What gene test is recommended for clopidogrel? | [
"The genetic test recommended for clopidogrel is CYP2C19 genotyping."
] | [
"CYP2C19 genotyping"
] | [
"polymorphisms in the CYP2C19 gene affect clopidogrel pharmacokinetics.",
"This study sought to evaluate the influence of single nucleotide polymorphisms (SNPs) on the pharmacodynamic effect of high- or standard-dose clopidogrel after percutaneous coronary intervention (PCI).",
"CYP2C19, but not PON1 or ABCB1, ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22674970",
"http://www.ncbi.nlm.nih.gov/pubmed/18004210",
"http://www.ncbi.nlm.nih.gov/pubmed/18577829",
"http://www.ncbi.nlm.nih.gov/pubmed/22624833",
"http://www.ncbi.nlm.nih.gov/pubmed/19706858",
"http://www.ncbi.nlm.nih.gov/pubmed/22088980",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0070166",
"o": "http://linkedlifedata.com/resource/umls/label/A0173515"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A01735... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003955",
"http://www.biosemantics.org/jochem#4260620",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005820",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&ter... |
56a24dfffe92d6fd19000002 | factoid | What is the role of eteplirsen in DMD patients? | [
"AVI-4658(eteplirsen) induces skipping of dystrophin exon 51 in patients with relevant deletions, restores the open reading frame and induces dystrophin protein expression after intramuscular (i.m.) injection."
] | [
"skipping of dystrophin exon 51"
] | [
"Duchenne muscular dystrophy (DMD) patients using the morpholino splice-switching oligonucleotide AVI-4658 (eteplirsen) that induces skipping of dystrophin exon 51 in patients with relevant deletions, restores the open reading frame and induces dystrophin protein expression after intramuscular (i.m.) injection",
... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22086232",
"http://www.ncbi.nlm.nih.gov/pubmed/23995279",
"http://www.ncbi.nlm.nih.gov/pubmed/23075107",
"http://www.ncbi.nlm.nih.gov/pubmed/24282529",
"http://www.ncbi.nlm.nih.gov/pubmed/23907995"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:11723",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020388",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009137",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+E... |
56c1f033ef6e39474100004f | summary | Describe clinical presentation of Parkinsonism with dementia of Guadeloupe syndrome. | [
"Parkinsonism with dementia of Guadeloupe is a unique combination of levodopa-resistant parkinsonism, tremor, myoclonus, hallucinations, REM sleep behavior disorder and fronto-subcortical dementia. Based on the presence or the absence of supranuclear gaze palsy, two subgroups of patients can be distinguished."
] | [] | [
"The clinical entity was a unique combination of levodopa-resistant parkinsonism, tremor, myoclonus, hallucinations, REM sleep behavior disorder and fronto-subcortical dementia. Based on the presence or the absence of supranuclear gaze palsy, two subgroups of patients were distinguished.",
"One-half of the patien... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12217621",
"http://www.ncbi.nlm.nih.gov/pubmed/17303592",
"http://www.ncbi.nlm.nih.gov/pubmed/21783505",
"http://www.ncbi.nlm.nih.gov/pubmed/16092100",
"http://www.ncbi.nlm.nih.gov/pubmed/18941145",
"http://www.ncbi.nlm.nih.gov/pubmed/18816693",
"http://www.ncbi.nlm.n... | [] | [] |
533eb89fc45e133714000012 | yesno | Does the concentration of protein HIF-1α increase after the administration of the cytoprotective prodrug"amifostine" (ethyol) ? | [
"The key-protein that when associated with HREs leads to the activation of all of these genes, is identified as“Hypoxia Inducible Factor-1” (HIF1). It is a heterodimer composed of two subunits (IIF1a 120kDa and HIF-1b 91-94kDa), both of which belong to the group of \"basic helix-loop-helix\" (bHLH)-Pas proteins. Th... | [
"yes"
] | [
"We demonstrated that the treatment of several human cancer cell lines with therapeutical doses of WR-1065 led to a strong induction of different VEGF-A mRNA isoforms independently of HIF-1alpha",
"e investigated the involvement of hypoxia-regulated proteins (Hypoxia inducible factors HIF1alpha, HIF2alpha and car... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17852557",
"http://www.ncbi.nlm.nih.gov/pubmed/24147016",
"http://www.ncbi.nlm.nih.gov/pubmed/20334641",
"http://www.ncbi.nlm.nih.gov/pubmed/19478935",
"http://www.ncbi.nlm.nih.gov/pubmed/21875443",
"http://www.ncbi.nlm.nih.gov/pubmed/21452059",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://data.linkedct.org/resource/intervention/5132",
"o": "Intervention #5132 (Drug:Ethyol (Amifostine))"
}
] | [
"http://www.uniprot.org/uniprot/HIF1A_BOSMU",
"http://www.biosemantics.org/jochem#4217067",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011355",
"http://www.biosemantics.org/jochem#4277891",
"http://www.uniprot.org/uniprot/HIF1A_EOSBA",
"http://www.nlm.nih.gov/cgi/me... |
514a11add24251bc05000054 | list | Which diseases can Oncotype DX be used for? | [
"Oncotype can be used for predicting breast cancer and colon cancer recurrence."
] | [
"breast cancer",
"colon cancer"
] | [
"Prognostic and predictive markers",
"Oncotype DX® currently allow avoidance of an over therapy or under therapy",
"a high score on the Oncotype DX gene expression profile r",
"poor-prognosis ER-positive breast cancers in need of more aggressive therapy",
"luminal B class",
"The 21-gene recurrence score (... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19946260",
"http://www.ncbi.nlm.nih.gov/pubmed/19101988",
"http://www.ncbi.nlm.nih.gov/pubmed/19536946",
"http://www.ncbi.nlm.nih.gov/pubmed/21934103",
"http://www.ncbi.nlm.nih.gov/pubmed/23074401",
"http://www.ncbi.nlm.nih.gov/pubmed/21176237",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A10812803",
"o": "Oncotype DX"
},
{
"p": "http://www.w3.org/2004/02/skos/core#note",
"s": "http://linkedlifedata.com/resource/umls/label/A7568412",
"o": "NCI Thesaurus"
},
{
... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001941",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003108",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003109"
] |
5165932e298dcd4e51000059 | list | Which are the DNA (cytosine-5-)-methyltransferases inhibitors? | [
"DNA (Cytosine-5-)-methyltransferases are a family of enzymes that methylate DNA at the C5 position of cytosine residues. Given that methylation of tumour suppressor gene promoters leads to carcinogenesis, inhibition of DNA (Cytosine-5-)-methyltransferases is a promising strategy for the treatment of cancer. There ... | [
"5-azacytidine",
"5-aza-CR",
"Vidaza®",
"5-azadeoxycytidine",
"5-aza-CdR",
"Dacogen®",
"5-aza-2'-deoxycytidine",
"Decitabine",
"5-azacytosine",
"ZCyt",
"5-fluorodeoxycytidine",
"FdC",
"5,6-dihydro-5-azacytosine",
"DZCyt",
"4'-thio-2'-deoxycytidine",
"hydralazine",
"2-(1H)-pyrimidinon... | [
"5-Aza-2'-deoxycytidine (5-Aza-CdR), a nucleoside analog that can inhibit DNA cytosine methylation, possesses potent antitumorigenic activities for myeloid disorders. Although 5-Aza-CdR is known to be incorporated into DNA and inhibit DNA (cytosine-5)-methyltransferases, the precise mechanisms underlying the drug's... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9925782",
"http://www.ncbi.nlm.nih.gov/pubmed/7536414",
"http://www.ncbi.nlm.nih.gov/pubmed/20808780",
"http://www.ncbi.nlm.nih.gov/pubmed/22259221",
"http://www.ncbi.nlm.nih.gov/pubmed/12368098",
"http://www.ncbi.nlm.nih.gov/pubmed/21796622",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004248",
"http://www.uniprot.org/uniprot/DCM_ECOLI",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004791"
] |
54cf42bdf693c3b16b000007 | summary | Describe armoured brain syndrome. | [
"Armoured brain syndrome is defined by calcified chronic subdural haematoma."
] | [] | [
"Armoured brain is a rare condition where dense calcification occurs over the brain.",
"Armoured brain due to chronic subdural collections masking underlying hydrocephalus.",
"Calcified chronic subdural collection (armoured brain) is a known long-standing complication of shunt overdrainage. ",
"The optimal su... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24403965",
"http://www.ncbi.nlm.nih.gov/pubmed/1580196",
"http://www.ncbi.nlm.nih.gov/pubmed/19902386",
"http://www.ncbi.nlm.nih.gov/pubmed/23421586",
"http://www.ncbi.nlm.nih.gov/pubmed/21319032"
] | [] | [] |
5131bef65274a5fb07000008 | list | Which are the main histone modifications associated with enhancers? | [
"Histone 3 lysine 4 mono- (H3K4me1) and di-methylation (H3K4me2) are the main post-transcriptional histone modifications related to enhancer activity.",
"Using H3K4me2 as a mark for active enhancers (PMID: 22270183) Hyperacetylation of histones H3 and H4, a mark of active chromatin, is established broadly across ... | [
"Histone 3 lysine 4 mono-methylation (H3K4me1)",
"Histone 3 lysine 4 di-methylation (H3K4me2)"
] | [
"Using H3K4me2 as a mark for active enhancers",
"Hyperacetylation of histones H3 and H4, a mark of active chromatin, is established broadly across target loci by enhancers that function over long distances",
"The enhancer region itself was marked by mono-methylation at K4 and K9, distinguishing it from the meth... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22270183",
"http://www.ncbi.nlm.nih.gov/pubmed/20621055",
"http://www.ncbi.nlm.nih.gov/pubmed/19021773"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056545"
] |
530f7d7fe3eabad021000002 | summary | What is the role of Thyrotropin Releasing Hormone in the treatment of comatose patients? | [
"Thyrotropin Releasing Hormone and its analogs are used for treatment of comatose patients. In animal models, Thyrotropin Releasing Hormone and its analogs have been shown to improve the disturbance of consciousness caused by head concussion and pentobarbital. This analeptic action is attributable to stimulation of... | [] | [
"Despite the correction of these metabolic disorders, the patient became comatose, and MRI, on T2 weighted image, showed hyperintense signals in the basal ganglia consistent with extra-pontine myelinolysis. The patient's state remained unchanged for six weeks. Since S. Konno and H. Wakui published cases of myelinol... | [
"http://www.ncbi.nlm.nih.gov/pubmed/3018425",
"http://www.ncbi.nlm.nih.gov/pubmed/8221703",
"http://www.ncbi.nlm.nih.gov/pubmed/9773038",
"http://www.ncbi.nlm.nih.gov/pubmed/2112565",
"http://www.ncbi.nlm.nih.gov/pubmed/2127684",
"http://www.ncbi.nlm.nih.gov/pubmed/8690305",
"http://www.ncbi.nlm.nih.gov... | [] | [
"http://www.uniprot.org/uniprot/TRH_NOTVI",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013973",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013812",
"http://www.uniprot.org/uniprot/TRH_BOMOR",
"http://www.uniprot.org/uniprot/TRH_... |
5139ec51bee46bd34c000006 | yesno | Do Conserved noncoding elements act as enhancers? | [
"An important percentage of noncoding elements conserved across distant species shows enhancer activity and other forms of regulatory functionality."
] | [
"yes"
] | [
"The aCNEs are rich in tissue-specific enhancers",
"Transgenic zebrafish assay of some human CNE enhancers that have been lost in teleosts",
"Conserved noncoding elements (CNEs) in vertebrate genomes often act as developmental enhancers,",
"In all four cases where the zebra fish and human CNE display a simila... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19492354",
"http://www.ncbi.nlm.nih.gov/pubmed/21629789",
"http://www.ncbi.nlm.nih.gov/pubmed/21081479",
"http://www.ncbi.nlm.nih.gov/pubmed/19782672",
"http://www.ncbi.nlm.nih.gov/pubmed/19805301",
"http://www.ncbi.nlm.nih.gov/pubmed/18562680",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004742",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0035326",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D026801",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=ui... |
54edef0594afd6150400000d | yesno | Can the iPS cell technology be used in Fanconi anemia therapy? | [
"iPS cell technology can be used for the generation of disease-corrected, patient-specific cells with potential value for cell therapy applications in Fanconi anemia."
] | [
"yes"
] | [
"We explain a protocol for the reproducible generation of genetically corrected iPSCs starting from the skin biopsies of Fanconi anemia patients using retroviral transduction with OCT4, SOX2 and KLF4",
"Before reprogramming, the fibroblasts and/or keratinocytes of the patients are genetically corrected with lenti... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20224565",
"http://www.ncbi.nlm.nih.gov/pubmed/19483674"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D057026",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051856",
"http://www.disease-ontology.org/api/metadata/DOID:13636",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+E... |
5324ce779b2d7acc7e00001e | factoid | Which drug is considered as the first line treatment of fibromyalgia? | [
"Pregabalin is, therefore, a valuable option in the first-line treatment of patients with fibromyalgia."
] | [
"Pregabalin"
] | [
"Multimodal approaches seem to be the treatment of choice in fibromyalgia",
"A multidisciplinary program was developed and implemented for patients with fibromyalgia in the primary care setting. The program included education (seven sessions) and physical therapy (25 sessions).",
"Amitriptyline for neuropathic ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23235657",
"http://www.ncbi.nlm.nih.gov/pubmed/18840008",
"http://www.ncbi.nlm.nih.gov/pubmed/21975791",
"http://www.ncbi.nlm.nih.gov/pubmed/17653994"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#broader",
"s": "http://linkedlifedata.com/resource/diseaseontology/id/DOID:1526",
"o": "http://linkedlifedata.com/resource/diseaseontology/id/DOID:631"
},
{
"p": "http://www.w3.org/2004/02/skos/core#prefLabel",
"s": "http://linkedlifedata.com/resou... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013812",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015673",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005356"
] |
5544da8f5beec11c10000004 | summary | What are the signatures of aggressive periodontitis? | [
"Aggressive periodontitis does not differ from chronic periodontitis from a microbial profile point of view but there are distinctive immunological signatures, including a higher expression in IgG against most periodontal pathogens and a more intense regulatory mechanism of metabolic processes."
] | [] | [
"This pilot study examined gene expression signatures in pathological gingival tissues of subjects with chronic or aggressive periodontitis, and explored whether new subclasses of periodontitis can be identified based on gene expression profiles. A total of 14 patients, seven with chronic and seven with aggressive ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15154918",
"http://www.ncbi.nlm.nih.gov/pubmed/18980520"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:824",
"http://www.disease-ontology.org/api/metadata/DOID:1474"
] |
56b773a96e3f8eaf4c000003 | list | With which complexes is the protein SUS1 associated? | [
"Sus1/ENY2 is a component of the SAGA and TREX-2 complexes"
] | [
"SAGA complex",
"TREX-2 complex"
] | [
"The yeast DUBm comprises a catalytic subunit, Ubp8, and three additional subunits, Sgf11, Sus1 and Sgf73, all of which are required for DUBm activity.",
"the deubiquitination module (DUBm) of SAGA, which is composed of Ubp8, Sus1, Sgf11, and Sgf73.",
"The conserved Sac3:Thp1:Sem1:Sus1:Cdc31 (TREX2) complex bin... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24705649",
"http://www.ncbi.nlm.nih.gov/pubmed/20395473",
"http://www.ncbi.nlm.nih.gov/pubmed/20434206",
"http://www.ncbi.nlm.nih.gov/pubmed/20230609",
"http://www.ncbi.nlm.nih.gov/pubmed/22499857",
"http://www.ncbi.nlm.nih.gov/pubmed/25526805",
"http://www.ncbi.nlm.n... | [
{
"p": "http://purl.uniprot.org/core/encodedBy",
"s": "http://purl.uniprot.org/uniprot/B4UN38",
"o": "http://linkedlifedata.com/resource/#_4234554E3338005"
},
{
"p": "http://purl.uniprot.org/core/recommendedName",
"s": "http://purl.uniprot.org/uniprot/B4UN38",
"o": "http://linkedlifedata... | [] |
52b2ed144003448f55000004 | yesno | Can Preimplantation Genetic Diagnosis (PGD) be used for gender selection? | [
"Preimplantation Genetic Diagnosis can be used for gender selection."
] | [
"yes"
] | [
"This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic abnormalities in prospective parents. ",
" Although many ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19294755",
"http://www.ncbi.nlm.nih.gov/pubmed/12470342",
"http://www.ncbi.nlm.nih.gov/pubmed/20102489",
"http://www.ncbi.nlm.nih.gov/pubmed/19251775",
"http://www.ncbi.nlm.nih.gov/pubmed/18829009",
"http://www.ncbi.nlm.nih.gov/pubmed/20638568",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012743",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005783",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019836"
] |
56ebee26107309bc2f000002 | summary | What is the principle of ATAC (Assay for Transposase-Accessible Chromatin) technique? | [
"ATAC-seq (Assay for Transposase-Accessible Chromatin) is an assay for transposase-accessible chromatin using sequencing, based on direct in vitro transposition of sequencing adaptors into native chromatin. ATAC is a rapid and sensitive method for integrative epigenomic analysis. ATAC-seq captures open chromatin si... | [] | [
"In conclusion, we show that FAIRE-seq and ATAC-seq based open chromatin profiling, combined with motif discovery, is a straightforward approach to identify functional genomic regulatory regions, master regulators, and gene regulatory networks controlling complex in vivo processes.",
"To this end, we first compar... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25679813",
"http://www.ncbi.nlm.nih.gov/pubmed/24097267"
] | [] | [
"http://www.uniprot.org/uniprot/TRAT_AMIAI"
] |
5516757c46478f2f2c000008 | list | Which are the main NMD factors in Saccharomyces cerevisiae? | [
"Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that accelerates the degradation of mRNAs containing premature translation termination codons. This quality control pathway depends on the NMD-specific factors, Upf1p, Upf2p/Nmd2p, and Upf3p, as well as the two release factors, eRF1 and eRF3 (respectiv... | [
"Upf1p",
"Nmd2p",
"Upf3p"
] | [
"In addition to their well-documented roles in the promotion of nonsense-mediated mRNA decay (NMD), yeast Upf proteins (Upf1, Upf2/Nmd2, and Upf3) also manifest translational regulatory functions, at least in vitro, including roles in premature translation termination and subsequent reinitiation",
"In Saccharomyc... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22065998",
"http://www.ncbi.nlm.nih.gov/pubmed/11073994",
"http://www.ncbi.nlm.nih.gov/pubmed/22227378",
"http://www.ncbi.nlm.nih.gov/pubmed/17705828",
"http://www.ncbi.nlm.nih.gov/pubmed/11238889",
"http://www.ncbi.nlm.nih.gov/pubmed/18087042",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012441",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000184"
] |
5160412d298dcd4e5100003c | list | Which histone marks are deposited by Set7? | [
"Set7 is H4K20 monomethyltransferase. Upregulation of PR-Set7 expression upon loss of HCF-1 leads to improper mitotic H4-K20 methylation. Set7 (or some variant) has also been reported to perform mono-methylation on lysine-4 of H3."
] | [
"H4K20 monomethylation",
"H3K4 monomethylation"
] | [
"the loss of H4 lysine 20 methylation",
"Transcriptionally competent regions lack H4 lysine 20 methylation",
"a human histone H4 lysine 20 methyltransferase and cloned the encoding gene, PR/SET07",
"Localization of PR-Set7 to mitotic chromosomes and subsequent increase in H4 Lys 20 methylation",
"the H4-K20... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12208845",
"http://www.ncbi.nlm.nih.gov/pubmed/21963854",
"http://www.ncbi.nlm.nih.gov/pubmed/15200950",
"http://www.ncbi.nlm.nih.gov/pubmed/12086618"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011495",
"http://www.uniprot.org/uniprot/SETD7_HALRO",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0042393",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006657",
"http... |
5322de919b2d7acc7e000012 | yesno | Has proteomics been used in the study of the dry eye syndrome? | [
"Yes, tears obtained from patients with the dry eye syndrome have been analyzed using different proteomic technologies."
] | [
"yes"
] | [
"Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry.",
"Dry eye syndrome in diabetic patients is associated with aberrant expression of tear proteins, and the findings could lead to identification of nov... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21384922",
"http://www.ncbi.nlm.nih.gov/pubmed/24282230",
"http://www.ncbi.nlm.nih.gov/pubmed/19705875",
"http://www.ncbi.nlm.nih.gov/pubmed/20882555",
"http://www.ncbi.nlm.nih.gov/pubmed/23272196"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015352",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005128",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005123",
"http://www.nlm.nih.gov/cgi/mesh/2... |
56c3184050c68dd416000003 | factoid | What is the indication for isradipine? | [
"Isradipine is safe and effective when administered long-term in the treatment of hypertensive patients",
"The calcium antagonist isradipine is used for hypertensive therapy."
] | [
"Hypertension"
] | [
"These are the preliminary data of an open multicenter trial of antihypertensive treatment with isradipine as monotherapy (dose, 4.55 +/- 0.56 mg twice daily; n = 11) or isradipine (7.5 +/- 0.63 mg twice daily) in combination with bopindolol (1.16 +/- 0.12 mg once daily; n = 30) administered for 3 years to patients... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8213473",
"http://www.ncbi.nlm.nih.gov/pubmed/10728516",
"http://www.ncbi.nlm.nih.gov/pubmed/8963604",
"http://www.ncbi.nlm.nih.gov/pubmed/2150641",
"http://www.ncbi.nlm.nih.gov/pubmed/15257873",
"http://www.ncbi.nlm.nih.gov/pubmed/8466736",
"http://www.ncbi.nlm.nih.g... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017275",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006973",
"http://www.biosemantics.org/jochem#4250298",
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4250298"... |
54df6ed91388e8454a000007 | list | List non-surgical treatment modalities that are included in the Stupp protocol. | [
"Radiotherapy and chemotherapy are non-surgical treatment modalities that are included in the Stupp protocol. This protocol is widely used for treatment of glioblastoma."
] | [
"radiotherapy",
"chemotherapy"
] | [
"OBJECTIVE: It is now accepted that the concomitant administration of temozolomide with radiotherapy (Stupp regime), in the treatment of patients with newly diagnosed glioblastoma multiforme (GBM), significantly improves survival and this practice has been adopted locally since 2004.",
"BACKGROUND: The introducti... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24111708",
"http://www.ncbi.nlm.nih.gov/pubmed/23453151",
"http://www.ncbi.nlm.nih.gov/pubmed/23254891",
"http://www.ncbi.nlm.nih.gov/pubmed/24600235",
"http://www.ncbi.nlm.nih.gov/pubmed/22464950",
"http://www.ncbi.nlm.nih.gov/pubmed/24287680",
"http://www.ncbi.nlm.n... | [] | [] |
54e22b62ae9738404b000011 | list | Which genes are associated with Ehlers-Danlos syndrome type I/II? | [
"It is currently estimated that approximately 50% of patients with a clinical diagnosis of classic Ehlers-Danlos syndrome harbor mutations in the COL5A1 and the COL5A2 gene, encoding the α1 and the α2-chain of type V collagen, respectively",
"Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a domina... | [
"COL5A1",
"COL5A2"
] | [
"It is currently estimated that approximately 50% of patients with a clinical diagnosis of classic Ehlers-Danlos syndrome harbor mutations in the COL5A1 and the COL5A2 gene, encoding the α1 and the α2-chain of type V collagen, respectively",
"In the majority of patients with molecularly characterized classic Ehle... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10796876",
"http://www.ncbi.nlm.nih.gov/pubmed/8923000",
"http://www.ncbi.nlm.nih.gov/pubmed/9425231",
"http://www.ncbi.nlm.nih.gov/pubmed/8541855",
"http://www.ncbi.nlm.nih.gov/pubmed/8752669",
"http://www.ncbi.nlm.nih.gov/pubmed/9783710",
"http://www.ncbi.nlm.nih.go... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:14720",
"http://www.disease-ontology.org/api/metadata/DOID:13359"
] |
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