id stringlengths 24 24 | type stringclasses 4
values | body stringlengths 13 215 | ideal_answer listlengths 1 12 | exact_answer listlengths 0 44 | snippets listlengths 0 121 | documents listlengths 1 157 | triples listlengths 0 537 | concepts listlengths 0 99 |
|---|---|---|---|---|---|---|---|---|
55031d82e9bde6963400002c | summary | What is the association between adiponectin and migraine? | [
"There is evidence to suggest that adiponectin plays a role in migraine. Increase in body fat elevates adiponectin and leptin secretion which in turn impair inflammatory processes that could be contributing to migraine risk. In episodic migraine patients, adiponectin was associated with migraine severity and predic... | [] | [
"Increase in body fat, especially in gluteofemoral region, elevates adiponectin and leptin secretion which in turn impair inflammatory processes that could be contributing to migraine risk.",
"CONCLUSION: In this pilot study of women episodic migraineurs, the HMW : LMW ADP ratio level was associated with migraine... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24648004",
"http://www.ncbi.nlm.nih.gov/pubmed/18474846",
"http://www.ncbi.nlm.nih.gov/pubmed/19556389",
"http://www.ncbi.nlm.nih.gov/pubmed/24819919",
"http://www.ncbi.nlm.nih.gov/pubmed/19845784",
"http://www.ncbi.nlm.nih.gov/pubmed/17448181",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:6364",
"http://www.uniprot.org/uniprot/ADIPO_HUMAN",
"http://www.uniprot.org/uniprot/ADIPO_MOUSE",
"http://www.uniprot.org/uniprot/ADIPO_BOVIN"
] |
55253d7087ecba3764000008 | summary | Which phenomenon is described as oncogene addiction? | [
" Oncogene addiction describes the curious acquired dependence of tumor cells on an activated oncogene for their survival and/or proliferation, a phenomenon that has important implications for the success of targeted cancer therapies. However, the mechanisms explaining oncogene addiction remain elusive. We propose... | [] | [
"Tumor cell growth and survival can often be impaired by inactivating a single oncogen- a phenomenon that has been called as \"oncogene addiction.\" It is in such scenarios that molecular targeted therapies may succeed.",
"The clinical efficacy of tyrosine kinase inhibitors supports the dependence of distinct sub... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22860051",
"http://www.ncbi.nlm.nih.gov/pubmed/20173739",
"http://www.ncbi.nlm.nih.gov/pubmed/21974937",
"http://www.ncbi.nlm.nih.gov/pubmed/22647359",
"http://www.ncbi.nlm.nih.gov/pubmed/23532334",
"http://www.ncbi.nlm.nih.gov/pubmed/21828272",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009857"
] |
515d9e5c298dcd4e5100000e | yesno | Are there randomised controlled trials on sevoflurane? | [
"Yes. There are < 10 studies reported, answering questions like : how to improve speed of recovery, relationship to dreaming and anesthetic experience, effect on cardiac troponin release, effect on myocardial injury, postoperative delirium, haemodynamics & emergence and recovery characteristics of total intravenou... | [
"yes"
] | [
"After Ethics Review Board approval, 44 ASA I-III patients undergoing elective gynaecological surgery were randomised after surgery to either hypercapnic hyperpnoea or control groups.",
"Hypercapnic hyperpnoea in spontaneously breathing patients halves the time of recovery from sevoflurane-induced anaesthesia in ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16867087",
"http://www.ncbi.nlm.nih.gov/pubmed/21733178",
"http://www.ncbi.nlm.nih.gov/pubmed/20683334",
"http://www.ncbi.nlm.nih.gov/pubmed/12693995",
"http://www.ncbi.nlm.nih.gov/pubmed/23452265",
"http://www.ncbi.nlm.nih.gov/pubmed/22577917",
"http://www.ncbi.nlm.n... | [] | [
"http://www.biosemantics.org/jochem#4252326"
] |
571ce13f7de986d80d000011 | factoid | In which cells are gasdermins expressed? | [
"Members of the novel gene family Gasdermin (Gsdm) are exclusively expressed in a highly tissue-specific manner in the epithelium of skin and the gastrointestinal tract."
] | [
"epithelial cells"
] | [
"Members of the novel gene family Gasdermin (Gsdm) are exclusively expressed in a highly tissue-specific manner in the epithelium of skin and the gastrointestinal tract. ",
"These results indicate that the mouse Gsdma and Gsdma3 genes share common function to regulate epithelial maintenance ",
"Gasdermin (GSDM ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19051310",
"http://www.ncbi.nlm.nih.gov/pubmed/23979942",
"http://www.ncbi.nlm.nih.gov/pubmed/15737203",
"http://www.ncbi.nlm.nih.gov/pubmed/18693275"
] | [] | [] |
550718e9fd1abe1741000001 | factoid | Where in a protein can a signal sequence be found? | [
"Proteins have signal sequences typically resent at the most N-terminal end."
] | [
"N-terminally"
] | [
"A transmembrane domain (TMD) at the N-terminus of a membrane protein is a signal sequence that targets the protein to the endoplasmic reticulum (ER) membrane. ",
" an N-terminal signal sequence,",
"soluble AMO possesses an N-terminal signal sequence",
"n N-terminal \"twin arginine\" signal sequence suggested... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8077949",
"http://www.ncbi.nlm.nih.gov/pubmed/12551941",
"http://www.ncbi.nlm.nih.gov/pubmed/9624150",
"http://www.ncbi.nlm.nih.gov/pubmed/8307567",
"http://www.ncbi.nlm.nih.gov/pubmed/8955395",
"http://www.ncbi.nlm.nih.gov/pubmed/21834515",
"http://www.ncbi.nlm.nih.g... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D021382"
] |
52b2ec944003448f55000002 | yesno | Can FOXOs modulate longevity? | [
"FOXOs are reliable markers of longevity."
] | [
"yes"
] | [
"Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan.",
"In contrast to FoxO1, FoxO3a and FoxO6 were specifically diminished in the CNS of HFD animals possibly contributing to the reduced lifespan observed in these animals.",
"Interestingly, many target proteins... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20874444",
"http://www.ncbi.nlm.nih.gov/pubmed/22438832",
"http://www.ncbi.nlm.nih.gov/pubmed/18208360",
"http://www.ncbi.nlm.nih.gov/pubmed/21076489",
"http://www.ncbi.nlm.nih.gov/pubmed/15942449",
"http://www.ncbi.nlm.nih.gov/pubmed/20592766",
"http://www.ncbi.nlm.n... | [
{
"p": "http://purl.uniprot.org/core/encodedBy",
"s": "http://purl.uniprot.org/uniprot/B4MB78",
"o": "http://linkedlifedata.com/resource/#_42344D42373800B"
},
{
"p": "http://purl.uniprot.org/core/orfName",
"s": "http://linkedlifedata.com/resource/#_42344D42373800B",
"o": "GJ14344"
},
... | [
"http://www.uniprot.org/uniprot/FOXO_DROME",
"http://www.uniprot.org/uniprot/FOXO_DROSE",
"http://www.uniprot.org/uniprot/FOXO_DROPE",
"http://www.uniprot.org/uniprot/FOXO_DROMO",
"http://www.uniprot.org/uniprot/FOXO_CAEEL",
"http://www.uniprot.org/uniprot/FOXO_DROPS",
"http://www.uniprot.org/uniprot/FO... |
56c1f039ef6e394741000052 | factoid | Which antibody is implicated in the Bickerstaff's brainstem encephalitis? | [
"The syndrome defined by Bickerstaff of progressive, external ophthalmoplegia and ataxia, with disturbance of consciousness or hyperreflexia, has subsequently been associated with antiganglioside antibody, anti-GQ1b"
] | [
"antiganglioside antibody"
] | [
"In addition, BBE and Fisher syndrome, which are clinically similar and are both associated with the presence of the immunoglobulin G anti-GQ1b antibody, represent a specific autoimmune disease with a wide spectrum of symptoms that include ophthalmoplegia and ataxia.",
"The syndrome defined by Bickerstaff of prog... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22698187",
"http://www.ncbi.nlm.nih.gov/pubmed/11442445",
"http://www.ncbi.nlm.nih.gov/pubmed/21631649",
"http://www.ncbi.nlm.nih.gov/pubmed/25379047",
"http://www.ncbi.nlm.nih.gov/pubmed/24853856",
"http://www.ncbi.nlm.nih.gov/pubmed/16844234",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004660",
"http://www.disease-ontology.org/api/metadata/DOID:9588"
] |
533c3533c45e133714000004 | list | Which micro-RNAs have been associated in the pathogenesis of Rheumatoid Arthritis? | [
"Different expression patterns of mir-146a, miRNA-155, miRNA-124a, mir-203, mir-223, mir-346, mir-132, mir-363, mir-498, mir-15a, and mir-16 were documented in several tissue sample types of RA patients."
] | [
"miR-155",
"miR-146a",
"miR-124a",
"miR-222",
"miR-223",
"miR-203",
"miR-346",
"miR-132",
"miR-363",
"miR-498",
"miR-15a",
"miR-16",
"miR-18a"
] | [
"This study provides the first description of increased expression of miRNA miR-155 and miR-146a in RA",
"In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue",
"The objective of this study... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20840794",
"http://www.ncbi.nlm.nih.gov/pubmed/18383392",
"http://www.ncbi.nlm.nih.gov/pubmed/21611196",
"http://www.ncbi.nlm.nih.gov/pubmed/23649045",
"http://www.ncbi.nlm.nih.gov/pubmed/21600203",
"http://www.ncbi.nlm.nih.gov/pubmed/18759964",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001172",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D035683",
"http://www.disease-ontology.org/api/metadata/DOID:7148",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:00... |
56c1f042ef6e394741000056 | yesno | Is there an association between FGFR3 mutation and plagiocephaly? | [
"Yes, FGFR3 mutation is associated with plagiocephaly. It is the most common mutation in plagiocephaly. FGFR genes have important effects on bone development, and mutations in 4 \"hot spot\" exons of FGFR1-3 are found in many patients with craniosynostosis and some with synostotic plagiocephaly."
] | [
"yes"
] | [
"Series of neurosurgical interventions were carried out, principally for acrocephaly and posterior plagiocephaly. The most common achondroplasia mutation, a p.Gly380Arg in the fibroblast growth factor receptor 3 (FGFR3) gene, was detected. ",
" The most common mutation for achondroplasia (FGFR3 Gly380Arg, resulti... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23949953",
"http://www.ncbi.nlm.nih.gov/pubmed/21739570",
"http://www.ncbi.nlm.nih.gov/pubmed/17693524",
"http://www.ncbi.nlm.nih.gov/pubmed/17992550",
"http://www.ncbi.nlm.nih.gov/pubmed/11743367",
"http://www.ncbi.nlm.nih.gov/pubmed/14577033",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/FGFR3_CHICK",
"http://www.uniprot.org/uniprot/FGFR3_MOUSE",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D049068",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009154",
"http://www.uniprot.org/uniprot/... |
533bf29cc45e133714000001 | yesno | Are CD44 variants (CD44v) associated with poor prognosis of metastasis? | [
"Yes, several isoforms (obtained by by usage of ten variant exons in various combinations) have been causally related to metastasis."
] | [
"yes"
] | [
"CD44 variants and prognosis",
"The CD44 variant (CD44v) isoforms have been noted as markers for tumour metastasis and prognosis in several adenocarcinomas.",
"Positive CD44v3 expression was associated with more advanced pathological stage and poorer prognosis than negative CD44v3 expression",
"CD44v6 express... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7587629",
"http://www.ncbi.nlm.nih.gov/pubmed/9732216",
"http://www.ncbi.nlm.nih.gov/pubmed/10601048",
"http://www.ncbi.nlm.nih.gov/pubmed/12842543",
"http://www.ncbi.nlm.nih.gov/pubmed/9849582",
"http://www.ncbi.nlm.nih.gov/pubmed/7585612",
"http://www.ncbi.nlm.nih.g... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009362",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011379",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018960",
"http://www.uniprot.org/uniprot/CD... |
515df98f298dcd4e51000030 | yesno | Is Bladder training an effective method to treat urge incontinence ? | [
"Yes. Bladder training is a simple, safe, and effective treatment in the management of mild to moderate forms of urinary incontinence in outpatient populations. It can be used as a first-line treatment or in combination with such other interventions as pelvic muscle exercises, bladder pressure biofeedback, electric... | [
"yes"
] | [
"Mindfulness-based stress reduction appears to be a treatment worthy of further study, as in the short term, it is as effective as historical studies of drug treatment and bladder training in reducing urge incontinence and incontinence-related quality of life.",
"All patients, irrespective of the results of cysto... | [
"http://www.ncbi.nlm.nih.gov/pubmed/2653554",
"http://www.ncbi.nlm.nih.gov/pubmed/8006342",
"http://www.ncbi.nlm.nih.gov/pubmed/3704568",
"http://www.ncbi.nlm.nih.gov/pubmed/8185987",
"http://www.ncbi.nlm.nih.gov/pubmed/12614251",
"http://www.ncbi.nlm.nih.gov/pubmed/19174937",
"http://www.ncbi.nlm.nih.g... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053202",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001745",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001743",
"http://www.nlm.nih.gov/cgi/mesh/2... |
56b77a866e3f8eaf4c000004 | summary | What is the scope of the OMIA database? | [
"Online Mendelian Inheritance in Animals (OMIA) is a comprehensive, annotated catalogue of inherited disorders and other familial traits in animals. OMIA is a comprehensive resource of phenotypic information on heritable animal traits and genes in a strongly comparative context, relating traits to genes where possi... | [] | [
"Online Mendelian Inheritance in Animals (OMIA),",
"Online Mendelian Inheritance in Animals (OMIA)",
"nline Mendelian Inheritance in Animals (OMIA) ",
"Online Mendelian Inheritance in Animals (OMIA)",
"Online Mendelian Inheritance in Animals (OMIA)",
"Online Mendelian Inheritance in Animals (OMIA) is a co... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16381939",
"http://www.ncbi.nlm.nih.gov/pubmed/21737319",
"http://www.ncbi.nlm.nih.gov/pubmed/22140104",
"http://www.ncbi.nlm.nih.gov/pubmed/18940862",
"http://www.ncbi.nlm.nih.gov/pubmed/21982513",
"http://www.ncbi.nlm.nih.gov/pubmed/17170002",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019991"
] |
515de127298dcd4e51000020 | summary | What is the effect of methotrexate in treating uveitis due to juvenile idiopathic arthritis ? | [
"The first-line standard therapy for uveitis is topical and systemic corticosteroids, often reinforced by methotrexate as a second-line disease-modifying antirheumatic drug (DMARD). MTX has a topical steroid sparing effect as well. Early treatment with MTX is advocated to prevent complications such as cataract. Th... | [] | [
"To characterize disease-modifying antirheumatic drug (DMARD) use for children with juvenile idiopathic arthritis (JIA) in the United States and to determine patient factors associated with medication use.",
"Among children without systemic arthritis, methotrexate use was most strongly associated with uveitis (OR... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17706583",
"http://www.ncbi.nlm.nih.gov/pubmed/19707402",
"http://www.ncbi.nlm.nih.gov/pubmed/17932849",
"http://www.ncbi.nlm.nih.gov/pubmed/22034564",
"http://www.ncbi.nlm.nih.gov/pubmed/15693100",
"http://www.ncbi.nlm.nih.gov/pubmed/22859354",
"http://www.ncbi.nlm.n... | [] | [] |
52f112bb2059c6d71c000002 | list | Which are the enzymes involved in the addition of 7-methylguanosine in mRNA? | [
"The 7-methylguanosine cap added to the 5′ end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been investigated. In some experimental systems, cap methylation ... | [
"RNA guanylyltransferase and 5'-phosphatase (RNGTT)",
"RNA guanylyltransferase and 5'-phosphatase",
"RNGTT",
"RNA guanine-7 methyltransferase",
"RNA guanine-7 methyltransferase (RNMT or hMTr1)",
"RNMT",
"hMTr1",
"RNMT-activating mini-protein",
"RNMT-activating mini-protein (RAM)",
"RAM",
"RNA po... | [
"In mammals, cap synthesis is catalysed by the sequential action of RNGTT (RNA guanylyltransferase and 5'-phosphatase) and RNMT (RNA guanine-7 methyltransferase), enzymes recruited to RNA pol II (polymerase II) during the early stages of transcription. We recently discovered that the mammalian cap methyltransferase... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20713356",
"http://www.ncbi.nlm.nih.gov/pubmed/7831320",
"http://www.ncbi.nlm.nih.gov/pubmed/24552703",
"http://www.ncbi.nlm.nih.gov/pubmed/21170289",
"http://www.ncbi.nlm.nih.gov/pubmed/23863084",
"http://www.ncbi.nlm.nih.gov/pubmed/956186",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.uniprot.org/uniprot/MCE1_MOUSE",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009452",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008618",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006370",
"http://www.biosemantics.org/jochem... |
56c8efef5795f9a73e000019 | summary | What is HOCOMOCO? | [
"HOCOMOCO is a comprehensive collection of human transcription factor binding sites models constructed by integration of binding sequences obtained by both low- and high-throughput methods. HOCOMOCO contains 426 systematically curated TFBS models for 401 human TFs, where 172 models are based on more than one data s... | [] | [
"HOCOMOCO: a comprehensive collection of human transcription factor binding sites models.",
"We present the Homo sapiens comprehensive model collection (HOCOMOCO, http://autosome.ru/HOCOMOCO/, http://cbrc.kaust.edu.sa/hocomoco/) containing carefully hand-curated TFBS models constructed by integration of binding s... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23175603"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014157"
] |
55203ae78e534a4535000001 | factoid | In which condition was protein S100A7 originally identified? | [
"Psoriasin (S100A7) was originally identified in psoriasis."
] | [
"psoriasis"
] | [
"Psoriasin (S100A7), originally identified in psoriasis, is a calcium-binding protein belonging to the multigenic S100 family",
"Psoriasin (S100 A7) was discovered two decades ago as a protein abundantly expressed in psoriatic keratinocytes. ",
" Psoriasin, originally isolated from psoriasis as an overexpressed... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22189627",
"http://www.ncbi.nlm.nih.gov/pubmed/21148126",
"http://www.ncbi.nlm.nih.gov/pubmed/21501383",
"http://www.ncbi.nlm.nih.gov/pubmed/21551409",
"http://www.ncbi.nlm.nih.gov/pubmed/19167844",
"http://www.ncbi.nlm.nih.gov/pubmed/20596736"
] | [] | [] |
513f3ab6bee46bd34c00000f | yesno | Do proton pump inhibitors affect thyroxine absorption? | [
"Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxine absorption.\nPatients with hypothyroidism and normal TSH values during LT4 replacement therapy may need additional thyroid function testing after treatment with PPIs and may need adjustment of their LT4 dose."
] | [
"yes"
] | [
"Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxine absorption",
"Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15073769",
"http://www.ncbi.nlm.nih.gov/pubmed/16477543",
"http://www.ncbi.nlm.nih.gov/pubmed/22019751",
"http://www.ncbi.nlm.nih.gov/pubmed/7865648",
"http://www.ncbi.nlm.nih.gov/pubmed/16971728",
"http://www.ncbi.nlm.nih.gov/pubmed/18942671",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A6850734",
"o": "Proton Pump Inhibitors"
}
] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017494",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054328"
] |
5357b5ecf1005d6b58000007 | yesno | Is PER3 required for CHK2 activation in human cells? | [
"Depletion of Per3 by siRNA almost completely abolished activation of checkpoint kinase 2 (Chk2) after inducing DNA damage in human cells.Per3, a circadian gene, is required for Chk2 activation in human cells.",
"Per3, a circadian gene, is required for Chk2 activation in human cells. ",
"Per3, a circadian gene... | [
"yes"
] | [
"Per3, a circadian gene, is required for Chk2 activation in human cells.",
"Depletion of Per3 by siRNA almost completely abolished activation of checkpoint kinase 2 (Chk2) after inducing DNA damage in human cells.",
"Per3 overexpression induced Chk2 activation in the absence of exogenous DNA damage,",
"Per3 o... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21070773"
] | [] | [
"http://www.uniprot.org/uniprot/CHK2_HUMAN",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D064447",
"http://www.uniprot.org/uniprot/PER3_HUMAN"
] |
532670e7d6d3ac6a34000008 | factoid | What is the typical alteration of the thyroid profile metabolism early after coronary artery bypass graft surgery? | [
"Low T3 Syndrome is the more frequent alteration of thyroid hormone profile early after coronary artery bypass graft surgery."
] | [
"Low T3 syndrome occurs frequently after CABG"
] | [
"FT3 concentration dropped significantly (p < 0.0001), reaching its lowest value 12 hours postoperatively. There were no significant differences between CPB and OPCAB patients. ",
"In on-pump CABG surgery, inflammatory effects encompass activation of total leukocytes, neutrophils and platelets, reduction of serum... | [
"http://www.ncbi.nlm.nih.gov/pubmed/6422832",
"http://www.ncbi.nlm.nih.gov/pubmed/15843233",
"http://www.ncbi.nlm.nih.gov/pubmed/22358266",
"http://www.ncbi.nlm.nih.gov/pubmed/12537197",
"http://www.ncbi.nlm.nih.gov/pubmed/9010711"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D047549",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013963",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001026",
"http://www.nlm.nih.gov/cgi/mesh/2... |
5358e067f1005d6b5800000b | list | Which proteins are involved in actin bundling and filopodia formation and function? | [
"A number of proteins have been found to regulate F-actin bundling and enhance filopodia formation and motility. Among these are Cysteine-rich protein 1 (CRP1), Fascin, Macrophage actin-associated tyrosine phosphorylated protein (MAYP/PSTPIP2), Insulin receptor tyrosine kinase substrate p53 (IRSp53), Missing in met... | [
"Cysteine-rich protein 1 (CRP1)",
"Fascin",
"Macrophage actin-associated tyrosine phosphorylated protein (MAYP/PSTPIP2)",
"Insulin receptor tyrosine kinase substrate p53 (IRSp53)",
"Missing in metastasis protein (MIM)",
"Eps8",
"Diaphanous-related formin (dDia2)",
"Vasodilator-stimulated phosphoprotei... | [
"CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth",
"CRP1, which cross-links actin filaments to make actin bundles, is the only CRP family member expressed in the CNS with little known about its function in nerve cells.",
"Here, we report that CRP1 colocalizes with actin i... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17115031",
"http://www.ncbi.nlm.nih.gov/pubmed/21283078",
"http://www.ncbi.nlm.nih.gov/pubmed/22090504",
"http://www.ncbi.nlm.nih.gov/pubmed/14752106",
"http://www.ncbi.nlm.nih.gov/pubmed/15788569",
"http://www.ncbi.nlm.nih.gov/pubmed/19228738",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011554",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051490",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032432",
"http://www.uniprot.org/uniprot/FSCN1_HUMAN",
"http://amigo.gene... |
56b76f496e3f8eaf4c000002 | factoid | What does the SAGA complex acronym stands for? | [
"SAGA stands for Spt-Ada-Gcn5-acetyltransferase (SAGA)"
] | [
"Spt-Ada-Gcn5-acetyltransferase"
] | [
"SAGA (Spt-Ada-Gcn5 Acetyltransferase)",
"SAGA (Spt-Ada-Gcn5-acetyltransferase)",
"Spt-Ada-Gcn5-acetyltransferase (SAGA) ",
"Spt-Ada-Gcn5-acetyltransferase (SAGA) complex is a transcription coactivator ",
"the yeast transcriptional coactivator Spt-Ada-Gcn5 acetyltransferase (SAGA)"
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/25015293",
"http://www.ncbi.nlm.nih.gov/pubmed/25441028",
"http://www.ncbi.nlm.nih.gov/pubmed/26100014",
"http://www.ncbi.nlm.nih.gov/pubmed/24509845",
"http://www.ncbi.nlm.nih.gov/pubmed/26528322"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A10002967",
"o": "C507785"
},
{
"p": "http://linkedlifedata.com/resource/umls/prefMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C1700223",
"o": "http://linkedlifedata.c... | [
"http://www.uniprot.org/uniprot/SGF29_YEAST",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000124",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036285",
"http://www.uniprot.org/uniprot/SGF73_YEAST",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=G... |
5319a7f2b166e2b80600002a | summary | What is the result of the interaction between TSC1 and PLK1? | [
"Phosphorylated TSC1 (hamartin) interacts with Plk1 independent of TSC2 (tuberin), with all three proteins present in a complex, and negatively regulates the protein levels of Plk1, to control centrosome duplication."
] | [] | [
"Phosphorylated hamartin interacts with Plk1 independent of tuberin with all three proteins present in a complex.",
"Hamartin negatively regulates the protein levels of Plk1.",
"Finally, Tsc1(-/-) mouse embryonic fibroblasts (MEFs) have increased number of centrosomes and increased DNA content, compared to Tsc1... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16339216"
] | [] | [
"http://www.uniprot.org/uniprot/TSC1_HUMAN",
"http://www.uniprot.org/uniprot/PLK1_HUMAN",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054730",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033596"
] |
53482bfcaeec6fbd07000010 | summary | What are the characteristics of the "Universal Proteomics Standard 2" (UPS2)? | [
"The UPS2 proteomic dynamic range standard was introduced by the Association of Biomolecular Resource Facilities Proteomics Standards Research Group in 2006 and it has a dynamic range of 5 orders of magnitude."
] | [] | [
"the UPS2 proteomic dynamic range standard introduced by The Association of Biomolecular Resource Facilities Proteomics Standards Research Group in 2006)",
"Universal Proteomics Standard sample with a dynamic range of 5 orders of magnitude (UPS2)."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/20823122",
"http://www.ncbi.nlm.nih.gov/pubmed/24195105"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020543",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D040901",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012015"
] |
56cae60f5795f9a73e00002b | factoid | Which polyQ tract protein is linked to Spinocerebellar Ataxia type 2? | [
"Ataxin-2 is an evolutionarily conserved protein first identified in humans as responsible for spinocerebellar ataxia type 2 (SCA2). The molecular basis of SCA2 is the expansion of a polyglutamine tract in Ataxin-2, encoding a Lsm domain that may bind RNA and a PAM2 motif that enables interaction with the poly (A) ... | [
"Ataxin 2"
] | [
"Ataxin-2 is an evolutionarily conserved protein first identified in humans as responsible for spinocerebellar ataxia type 2 (SCA2). The molecular basis of SCA2 is the expansion of a polyglutamine tract in Ataxin-2, encoding a Lsm domain that may bind RNA and a PAM2 motif that enables interaction with the poly (A) ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25027299",
"http://www.ncbi.nlm.nih.gov/pubmed/19625506",
"http://www.ncbi.nlm.nih.gov/pubmed/10973246",
"http://www.ncbi.nlm.nih.gov/pubmed/24486837"
] | [] | [] |
56e0447a51531f7e3300000b | factoid | Which are the smallest known subviral pathogens of plants? | [
"Contrary to earlier beliefs, viruses are not the smallest causative agents of infectious diseases. Single-stranded RNAs as small as 246 nucleotides exist in certain higher plants and cause more than a dozen crop diseases. These RNAs have been termed viroids. Viroids are plant subviral pathogens whose genomes are c... | [
"Viroids"
] | [
"Since the discovery of non-coding, small, highly structured, satellite RNAs (satRNAs) and viroids as subviral pathogens of plants , have been of great interest to molecular biologists as possible living fossils of pre-cellular evolution in an RNA world.",
"PFOR2 analysis of the small RNA libraries from grapevine... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10494833",
"http://www.ncbi.nlm.nih.gov/pubmed/10592219",
"http://www.ncbi.nlm.nih.gov/pubmed/25503469",
"http://www.ncbi.nlm.nih.gov/pubmed/16519798",
"http://www.ncbi.nlm.nih.gov/pubmed/25731957",
"http://www.ncbi.nlm.nih.gov/pubmed/15231279",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010944"
] |
56bb621fac7ad10019000009 | factoid | What causes Katayama Fever? | [
"Katayama fever is an acute clinical condition characterised by high fever, dry cough and general malaise occurring during early Schistosoma spp. infection."
] | [
"Schistosoma spp"
] | [
"The laboratory diagnosis of schistosomiasis and Katayama syndrome in returning travellers is difficult because the number of excreted eggs is often very limited.",
"Eosinophilia (sometimes exceeding 50%) is often present in patients with acute schistosomiasis (Katayama fever), but may be limited or absent in lat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24985919",
"http://www.ncbi.nlm.nih.gov/pubmed/24916752",
"http://www.ncbi.nlm.nih.gov/pubmed/8115806",
"http://www.ncbi.nlm.nih.gov/pubmed/1411323",
"http://www.ncbi.nlm.nih.gov/pubmed/2511623",
"http://www.ncbi.nlm.nih.gov/pubmed/15582175",
"http://www.ncbi.nlm.nih.... | [] | [] |
52f893f92059c6d71c00003c | list | List clinical trials for prevention of sarcopenia | [
"Several clinical trials with androgen replacement therapy. \nStudy was to evaluate the effect of omega-3 fatty acid supplementation on the rate of muscle protein synthesis. This trial was registered at clinical trials.gov as NCT00794079"
] | [
"androgen replacement trials",
"omega-3 fatty acid supplementation",
"NCT00794079"
] | [
"several clinical trials with androgen replacement therapy have failed to show clinical benefit.",
"Clinical trials are needed to find better interventions for this syndrome.",
"emergence of many promising interventions towards this age-related condition (e.g., physical exercise [in particular, resistance train... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21968872",
"http://www.ncbi.nlm.nih.gov/pubmed/18615229",
"http://www.ncbi.nlm.nih.gov/pubmed/22739566",
"http://www.ncbi.nlm.nih.gov/pubmed/23892221",
"http://www.ncbi.nlm.nih.gov/pubmed/21159787"
] | [
{
"p": "http://data.linkedct.org/resource/linkedct/condition",
"s": "http://data.linkedct.org/resource/trials/NCT00557388",
"o": "http://data.linkedct.org/resource/condition/11756"
},
{
"p": "http://data.linkedct.org/resource/linkedct/condition_name",
"s": "http://data.linkedct.org/resource/... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016032",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002986",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055948",
"http://www.nlm.nih.gov/cgi/mesh/2... |
554140ad182542114d000003 | factoid | Which is the database of molecular recognition features in membrane proteins? | [
"mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins.",
"mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins ",
"mpMoRFsDB provides valuable information related to disorder-based prot... | [
"mpMoRFsDB"
] | [
"mpMoRFsDB: a database of molecular recognition features in membrane proteins",
"mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins",
"mpMoRFsDB: a database of molecular recognition features in membrane proteins."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/24093637",
"http://www.ncbi.nlm.nih.gov/pubmed/23894139",
"http://www.ncbi.nlm.nih.gov/pubmed/23328413"
] | [] | [] |
554148c23f2354b713000001 | factoid | Which database is available for the identification of chorion proteins in Lepidopteran proteomes? | [
"LepChorionDB"
] | [
"LepChorionDB"
] | [
"LepChorionDB, a database of Lepidopteran chorion proteins and a set of tools useful for the identification of chorion proteins in Lepidopteran proteomes",
"A database, named LepChorionDB, was constructed by searching 5 different protein databases using class A and B central domain-specific profile Hidden Markov ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23262288"
] | [] | [] |
5324cf869b2d7acc7e000020 | yesno | Are there any clinical trials of the effect of evening primrose oil on postmenopausal symptoms ? | [
"Yes"
] | [
"yes"
] | [
"To analyze whether the time (morning/evening) of administration of a compound containing 60 mg of dry soy seed extract (glycine max) with 40% of total isoflavones, primrose oil and α-tocopherol modifies the effect on the climacteric syndrome.",
"The object of this study was to evaluate the effect of different do... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17593379",
"http://www.ncbi.nlm.nih.gov/pubmed/12435217",
"http://www.ncbi.nlm.nih.gov/pubmed/8136666",
"http://www.ncbi.nlm.nih.gov/pubmed/14716179",
"http://www.ncbi.nlm.nih.gov/pubmed/23625331",
"http://www.ncbi.nlm.nih.gov/pubmed/20979541",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://data.linkedct.org/resource/linkedct/condition",
"s": "http://data.linkedct.org/resource/trials/NCT00381251",
"o": "http://data.linkedct.org/resource/condition/10439"
},
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://data.linkedct.org/resource/condition/10439... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004042",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D031825",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016430",
"http://www.nlm.nih.gov/cgi/mesh/2... |
572099930fd6f91b6800000f | yesno | Is acid alpha-glucosidase the enzyme that causes Pompe disease when mutant? | [
"Pompe disease is an autosomal recessive genetic disorder characterized by a deficiency of the enzyme responsible for degradation of lysosomal glycogen (acid α-glucosidase (GAA))",
"Pompe disease is an autosomal recessive genetic disorder characterized by a deficiency of the enzyme acid α-glucosidase (GAA), respo... | [
"yes"
] | [
"Pompe disease is an autosomal recessive genetic disorder characterized by a deficiency of the enzyme responsible for degradation of lysosomal glycogen (acid α-glucosidase (GAA))",
"Pompe disease is a systemic metabolic disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosom... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18648322",
"http://www.ncbi.nlm.nih.gov/pubmed/25256446",
"http://www.ncbi.nlm.nih.gov/pubmed/26029718",
"http://www.ncbi.nlm.nih.gov/pubmed/14643388",
"http://www.ncbi.nlm.nih.gov/pubmed/17805474",
"http://www.ncbi.nlm.nih.gov/pubmed/16702882",
"http://www.ncbi.nlm.n... | [] | [] |
56cb9b065795f9a73e000032 | factoid | Which kinase is inhibited by Tripolin A? | [
"Tripolin A reduced the localization of pAurora A on spindle microtubules (MTs), affected centrosome integrity, spindle formation and length, as well as MT dynamics in interphase, consistent with Aurora A inhibition by RNAi or other specific inhibitors, such as MLN8054 or MLN8237. Interestingly, Tripolin A affected... | [
"Aurora A"
] | [
"Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules.",
"The human Aurora kinases are a family of such targets. In this study, from a panel of 105 potential small-molecule inhibitors, two compounds Tripolin A and Tripolin B, inhibited Auro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23516487"
] | [] | [] |
56e073ad51531f7e3300000e | yesno | Is the optogenetics tool ChR2 light-sensitive? | [
"Channelrhodospin-2 (ChR2) is a light-sensitive ion channel that has emerged as new optogenetics tool."
] | [
"yes"
] | [
"Channelrhodospin-2 (ChR2), a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology.",
"Light-sensitive genes chiefly including the genetically targeted light-gated channels channelrhodo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25571406",
"http://www.ncbi.nlm.nih.gov/pubmed/23664865",
"http://www.ncbi.nlm.nih.gov/pubmed/25303540",
"http://www.ncbi.nlm.nih.gov/pubmed/23002710",
"http://www.ncbi.nlm.nih.gov/pubmed/23380919",
"http://www.ncbi.nlm.nih.gov/pubmed/23366158",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062308"
] |
5327139ad6d3ac6a3400000d | yesno | Is the Prostate- Specific Antigen (PSA) test relevant only for prostate cancer? | [
"No, although the PSA test can detect high levels of PSA that may indicate the presence of prostate cancer, many other conditions, such as an enlarged or inflamed prostate, can also increase PSA levels."
] | [
"no"
] | [
"rostate cancer (PCa) is the most frequently diagnosed malignancy and the second leading cause of cancer death in men",
"PSA is known to be prostate specific, but not PCa specific",
"deficiencies of serum PSA as a prostate-cancer-specific diagnostic test are well recognized.",
"medical debate surrounding the ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12088291",
"http://www.ncbi.nlm.nih.gov/pubmed/9494603",
"http://www.ncbi.nlm.nih.gov/pubmed/7544735",
"http://www.ncbi.nlm.nih.gov/pubmed/24223021",
"http://www.ncbi.nlm.nih.gov/pubmed/18808732",
"http://www.ncbi.nlm.nih.gov/pubmed/9494604",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011471",
"http://www.uniprot.org/uniprot/KLK3_MACFA",
"http://www.disease-ontology.org/api/metadata/DOID:10283",
"http://www.disease-ontology.org/api/metadata/DOID:10286",
"http://www.uniprot.org/uniprot/KLK3_MACMU",
"http:... |
56bdfa73ef6e394741000003 | list | List symptoms of Hakim Triad. | [
"Triad of Hakim--Adams is well known for normal pressure hydrocephalus (NPH): dementia, gait disturbances and urinary incontinence."
] | [
"dementia",
"gait disturbances",
"urinary incontinence"
] | [
"Triad of Hakim--Adams is well known for normal pressure hydrocephalus (NPH): dementia, gait disturbances and urinary incontinence.",
"Normal pressure hydrocephalus (NPH) is a clinical triad of gait disturbance, dementia, and urinary incontinence combined with radiographic findings of ventriculomegaly and laborat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19823916",
"http://www.ncbi.nlm.nih.gov/pubmed/21698923",
"http://www.ncbi.nlm.nih.gov/pubmed/6583309",
"http://www.ncbi.nlm.nih.gov/pubmed/21194654",
"http://www.ncbi.nlm.nih.gov/pubmed/20568668"
] | [] | [] |
53188480b166e2b806000018 | factoid | Which is the cellular target of gefitinib? | [
"The specific cellular target of Gefitinib (Iressa) is the epidermal growth factor receptor (EGFR)."
] | [
"Epidermal growth factor receptor (EGFR)"
] | [
"Gefitinib, the specific inhibitor of the epidermal growth factor receptor (EGFR), may cause growth delay in cancer cell lines.",
"Gefitinib (Iressa) is a specific and effective epidermal growth factor receptor inhibitor.",
"Gefitinib is a specific inhibitor of the epidermal growth factor receptor (EGFR) that c... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19276163",
"http://www.ncbi.nlm.nih.gov/pubmed/18089711",
"http://www.ncbi.nlm.nih.gov/pubmed/23255952"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D058990",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016503",
"http://www.biosemantics.org/jochem#4274201",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&ter... |
56f96333cf1c325851000004 | list | What kind of bonds are connecting keratin molecules? | [
"cystine disulfide bonds\namide bonds\nhydrogen bonds"
] | [
"cystine disulfide bonds",
"amide bonds",
"hydrogen bonds"
] | [
" Feathers and hair consist of cornified epidermal keratinocytes in which proteins are crosslinked via disulfide bonds between cysteine residues of structural proteins to establish mechanical resilience.",
" The method involves the generation of thiols by controlled reduction of cystine disulfide bonds in keratin... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24276370",
"http://www.ncbi.nlm.nih.gov/pubmed/19925868",
"http://www.ncbi.nlm.nih.gov/pubmed/24971553",
"http://www.ncbi.nlm.nih.gov/pubmed/24367993",
"http://www.ncbi.nlm.nih.gov/pubmed/23466495",
"http://www.ncbi.nlm.nih.gov/pubmed/25947341",
"http://www.ncbi.nlm.n... | [] | [] |
5727b6410fd6f91b6800001b | yesno | Is autism one of the characteristics of Moebius syndrome? | [
"Moebius syndrome is a rare congenital disorder usually defined as a combination of facial weakness with impairment of ocular abduction. A strong association of Moebius syndrome with autism spectrum disorders (ASDs) has been suggested in early studies with heterogenous age groups."
] | [
"yes"
] | [
"The diagnosis of Moebius syndrome, a rare congenital disorder, is primarily based on congenital facial and abducent nerve palsy. Involvement of other cranial nerves is also common. Occasionally the V, X, XI, and XII cranial nerves are involved, resulting in a difficulty to chew, swallow, and cough, which often lea... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15736079",
"http://www.ncbi.nlm.nih.gov/pubmed/22832772",
"http://www.ncbi.nlm.nih.gov/pubmed/20621443",
"http://www.ncbi.nlm.nih.gov/pubmed/19255803",
"http://www.ncbi.nlm.nih.gov/pubmed/1623312",
"http://www.ncbi.nlm.nih.gov/pubmed/2929356"
] | [] | [] |
55016397e9bde69634000006 | yesno | Is Sarcolipin a regulatory/inhibitory protein of the Calcium ATPase SERCA? | [
"Sarcolipin (SLN) is a 3 kD membrane protein found in sarcoplasmic reticulum (SR) and it is a newly identified regulator of the sarco/endoplasmic reticulum Ca(2+)-ATPase (Serca) pump. SLN inhibits sarcoplasmic reticulum Ca(2+) ATPase (SERCA) activity and reduces its affinity of Ca(2+), resulting in dysfunction of ... | [
"yes"
] | [
"The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16519897",
"http://www.ncbi.nlm.nih.gov/pubmed/17515962",
"http://www.ncbi.nlm.nih.gov/pubmed/18081313",
"http://www.ncbi.nlm.nih.gov/pubmed/16036219",
"http://www.ncbi.nlm.nih.gov/pubmed/20833651",
"http://www.ncbi.nlm.nih.gov/pubmed/12032137",
"http://www.ncbi.nlm.n... | [] | [
"http://www.biosemantics.org/jochem#4264789",
"http://www.uniprot.org/uniprot/SARCO_MOUSE",
"http://www.uniprot.org/uniprot/SARCO_HUMAN",
"http://www.uniprot.org/uniprot/SARCO_RAT",
"http://www.uniprot.org/uniprot/SARCO_RABIT",
"http://www.uniprot.org/uniprot/AT2A_CHIOP",
"http://www.nlm.nih.gov/cgi/mes... |
54ede76294afd61504000008 | factoid | What is the risk of developing acute myelogenous leukemia in Fanconi anemia? | [
"A review of all of the cases of Fanconi anemia (FA) reported to the International Fanconi Anemia Registry (IFAR) indicates that at least 15% manifest acute myelogenous leukemia (AML) or preleukemia.",
"A review of all of the cases of Fanconi anemia (FA) reported to the International Fanconi Anemia Registry (IFAR... | [
"At least 15%, based on the International Fanconi Anemia Registry (IFAR)"
] | [
"Sixteen of the 59 FA-C patients (27%) have developed acute myelogenous leukemia",
"Actuarial risk of MDS or AML was 52% (37% to 67%) by 40 years of age",
"A review of all of the cases of Fanconi anemia (FA) reported to the International Fanconi Anemia Registry (IFAR) indicates that at least 15% manifest acute ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8068955",
"http://www.ncbi.nlm.nih.gov/pubmed/9207444",
"http://www.ncbi.nlm.nih.gov/pubmed/1548931"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:13636",
"http://www.disease-ontology.org/api/metadata/DOID:8692",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005199",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051856",
"http:/... |
52c7311903868f1b0600001d | factoid | How many different mutations have been associated with Muenke syndrome? | [
"Muenke syndrome, also known as FGFR3-associated coronal synostosis, is defined molecularly by the presence of a heterozygous nucleotide transversion, c.749C>G, encoding the amino acid substitution Pro250Arg, in the fibroblast growth factor receptor type 3 gene (FGFR3)."
] | [
"One"
] | [
"Muenke syndrome is an autosomal dominant craniosynostosis syndrome resulting from a defining point mutation in the Fibroblast Growth Factor Receptor3 (FGFR3) gene. ",
"The associated of FGFR3 mutations with craniosynostosis has been restricted to three mutations, the common p.Pro250Arg in Muenke syndrome, p.Ala3... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15241680",
"http://www.ncbi.nlm.nih.gov/pubmed/22038757",
"http://www.ncbi.nlm.nih.gov/pubmed/19215249",
"http://www.ncbi.nlm.nih.gov/pubmed/19755431",
"http://www.ncbi.nlm.nih.gov/pubmed/21403557",
"http://www.ncbi.nlm.nih.gov/pubmed/23378035"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#note",
"s": "http://linkedlifedata.com/resource/umls/label/A18449528",
"o": "MeSH"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1864436",
"o": "http://linkedlifedata.com/resource/umls... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009154",
"http://www.disease-ontology.org/api/metadata/DOID:225"
] |
571366ba1174fb1755000005 | factoid | How can the fetal Rhesus be determined with non-invasive testing? | [
"The detection of fetal RhD status can be achieved with the non-invasive method of assessing free fetal DNA in the maternal blood."
] | [
"free fetal DNA from maternal cirulcation"
] | [
"Determination of fetal rhesus d status by maternal plasma DNA analysis.",
"In this study, we assessed the feasibility of fetal RhD genotyping by analysis of cell-free fetal DNA(cffDNA) extracted from plasma samples of Rhesus (Rh) D-negative pregnant women by using real-time polymerase chain reaction (PCR).",
"... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25380024",
"http://www.ncbi.nlm.nih.gov/pubmed/24778561",
"http://www.ncbi.nlm.nih.gov/pubmed/21686347",
"http://www.ncbi.nlm.nih.gov/pubmed/10985940",
"http://www.ncbi.nlm.nih.gov/pubmed/24204719",
"http://www.ncbi.nlm.nih.gov/pubmed/22386678",
"http://www.ncbi.nlm.n... | [] | [] |
54c90dabf693c3b16b000004 | list | Which genes have been proposed as potential candidates for gene therapy of heart failure? | [
"There are at least 6 genes which have been proposed as potential candidates of gene therapy in heart failure.\n1. Cardiac Sarco-Endoplasmic Reticulum Calcium ATPase 2A (SERCA2A)\n2. Inhibitor 1 (I-1) of Protein Phosphatase 1B\n3. Protein Phosphatase 1B (PP1B)\n4. Yes Associated Protein (YAP)\n5. Survivin\n6. S100A... | [
"Sarco-Endoplasmic Reticulum Calcium ATPase 2A",
"(SERCA2A)",
"Inhibitor 1 of Protein Phosphatase 1B",
"(I-1)",
"Protein Phosphatase 1B",
"(PP1B)",
"Yes Associated Protein",
"(YAP)",
"Survivin",
"S100A1"
] | [
"The molecular abnormalities underlying HF are discussed along with potential targets for gene therapy, focusing on SERCA2a.",
"The aim of this study was to improve cardiac function in chronic HF by overexpressing constitutively active inhibitor-1 (I-1c) ",
"In summary, I-1c overexpression using BNP116 improves... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23281410",
"http://www.ncbi.nlm.nih.gov/pubmed/24403316",
"http://www.ncbi.nlm.nih.gov/pubmed/21775667",
"http://www.ncbi.nlm.nih.gov/pubmed/24833660",
"http://www.ncbi.nlm.nih.gov/pubmed/22558250",
"http://www.ncbi.nlm.nih.gov/pubmed/22362515",
"http://www.ncbi.nlm.n... | [] | [] |
54f1e031c409818c32000001 | factoid | DX-88 is investigational name of which drug? | [
"DX-88 is investigational name of a drug Ecallantide, a 60-amino acid recombinant protein discovered through phage display technology, that is a highly specific, potent inhibitor of human plasma kallikrein that has been used successfully in the treatment of patients experiencing acute hereditary angioedema attacks.... | [
"Ecallantide"
] | [
"Ecallantide (known as DX-88 previously), a potent and specific inhibitor of plasma kallikrein is an innovative medicinal product. ",
"Ecallantide (DX-88) for acute hereditary angioedema attacks: integrated analysis of 2 double-blind, phase 3 studies.",
"Several novel therapies have completed phase III trials i... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18467921",
"http://www.ncbi.nlm.nih.gov/pubmed/19093699",
"http://www.ncbi.nlm.nih.gov/pubmed/18220151",
"http://www.ncbi.nlm.nih.gov/pubmed/21481442",
"http://www.ncbi.nlm.nih.gov/pubmed/14572819",
"http://www.ncbi.nlm.nih.gov/pubmed/21760740",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015507"
] |
5507ea9a0195c16935000008 | summary | What type of arrhythmia is known as bidirectional ventricular tachycardia (BDVT)? | [
"Bidirectional ventricular tachycardia (BVT), which is characterized by an alternating beat-to-beat ECG QRS axis, is a rare but intriguing arrhythmia associated with digitalis toxicity, familial catecholaminergic polymorphic ventricular tachycardia (CPVT), and several other conditions that predispose cardiac myocyt... | [] | [
"Bidirectional ventricular tachycardia (BVT) is an uncommon type of polymorphic ventricular tachycardia (PVT) with alternating polarity of the QRS complex most commonly described digitalis toxicity. ",
"Bidirectional ventricular tachycardia (BVT), which is characterized by an alternating beat-to-beat ECG QRS axis... | [
"http://www.ncbi.nlm.nih.gov/pubmed/14556882",
"http://www.ncbi.nlm.nih.gov/pubmed/6180691",
"http://www.ncbi.nlm.nih.gov/pubmed/21118730",
"http://www.ncbi.nlm.nih.gov/pubmed/23094889",
"http://www.ncbi.nlm.nih.gov/pubmed/19682706",
"http://www.ncbi.nlm.nih.gov/pubmed/1713403",
"http://www.ncbi.nlm.nih... | [] | [] |
52f8995b2059c6d71c00004a | list | Which genes have been found to be associated with restless leg syndrome | [
"Human L-Ferritin\nThe genotypes of five specific single-nucleotide polymorphisms (SNPs) in three genes\nHomozygosity for the T-allele of BTBD9 rs9296249\nMEIS1\nIntragenic guanosine triphosphate cyclohydrolase-1 duplication\nLRRK2 gene mutation"
] | [
"LRRK2 gene mutation",
"Human L-Ferritin",
"The genotypes of five specific single-nucleotide polymorphisms (SNPs) in three genes",
"Homozygosity for the T-allele of BTBD9 rs9296249",
"MEIS1",
"Intragenic guanosine triphosphate cyclohydrolase-1 duplication"
] | [
"We describe a unique case of a 23-yr-old female patient affected by a homozygous loss of function mutation in the L-ferritin gene, idiopathic generalized seizures, and atypical restless leg syndrome (RLS). ",
"The genotypes of five specific single-nucleotide polymorphisms (SNPs) in three genes that have been pre... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21572129",
"http://www.ncbi.nlm.nih.gov/pubmed/18032746",
"http://www.ncbi.nlm.nih.gov/pubmed/22486183",
"http://www.ncbi.nlm.nih.gov/pubmed/21287604",
"http://www.ncbi.nlm.nih.gov/pubmed/23940258",
"http://www.ncbi.nlm.nih.gov/pubmed/23227859"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012148"
] |
56bf7d90ef6e394741000015 | yesno | Is the circadian clock involved in ribosome biogenesis? | [
"Yes. The circadian clock coordinates ribosome biogenesis. It influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulat... | [
"yes"
] | [
"The circadian clock coordinates ribosome biogenesis.",
"Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23300384"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A18469688",
"o": "D057906"
},
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A18451217",
"o": "D057906"
},
{
"p":... | [
"http://amigo.geneontology.org/amigo/term/GO:0042254",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D057906"
] |
52b2f0864003448f55000007 | yesno | Can mutations in Calmodulin cause ventricular fibrillation? | [
"Yes, mutations in CALM underly IVF manifesting in childhood and adolescence."
] | [
"yes"
] | [
"We characterized a family presenting with a history of ventricular fibrillation (VF) and sudden death without ECG or echocardiographic abnormalities at rest. Two siblings died suddenly at the ages of 9 and 10 years, and another two were resuscitated from out-of-hospital cardiac arrest with documented VF at age 10 ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24076290",
"http://www.ncbi.nlm.nih.gov/pubmed/11807557"
] | [] | [
"http://www.uniprot.org/uniprot/CALM_PARTE",
"http://www.uniprot.org/uniprot/CALM_ANAPL",
"http://www.uniprot.org/uniprot/CALM_PNECA",
"http://www.uniprot.org/uniprot/CALM_BRYDI",
"http://www.uniprot.org/uniprot/CALM_PFIPI",
"http://www.uniprot.org/uniprot/CALM_SHEEP",
"http://www.nlm.nih.gov/cgi/mesh/2... |
56c4d14ab04e159d0e000003 | factoid | Do the Sleeping Beauty or the piggyBac transposons have higher transposition efficiency? | [
"Compared with Sleeping Beauty, PiggyBac exhibits higher transposition efficiencies."
] | [
"piggyBac"
] | [
"Compared with Sleeping Beauty, PiggyBac exhibits higher transposition efficiencies, no evidence for local hopping and a significant bias toward reintegration in intragenic regions, which demonstrate its utility for insertional mutagenesis. ",
"We found that PB demonstrated the highest efficiency of stable gene t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21516337",
"http://www.ncbi.nlm.nih.gov/pubmed/17005721",
"http://www.ncbi.nlm.nih.gov/pubmed/20606646",
"http://www.ncbi.nlm.nih.gov/pubmed/19391106",
"http://www.ncbi.nlm.nih.gov/pubmed/17164785"
] | [] | [] |
56cdf4fe5795f9a73e000044 | summary | Where does TORC1 sequester during heat stress? | [
"Upon heat stress, TORC1 is recruited to stress granules."
] | [] | [
"Transient sequestration of TORC1 into stress granules during heat stress.",
"Here we report that TORC1 signaling upon heat stress is regulated by stress granules (SGs), which are cytoplasmic foci formed under certain stresses. Ectopic formation of SGs achieved by Pbp1 overexpression in unstressed cells sequester... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22727621"
] | [] | [] |
532f09d2d6d3ac6a3400002b | yesno | Is rivaroxaban metabolized in kidneys? | [
"rivaroxaban undergoes renal metabolism"
] | [
"yes"
] | [
"The novel oral anticoagulants (i.e., dabigatran, apixaban, rivaroxaban) all undergo renal metabolism to varying degrees, and hence dosing, efficacy, and safety require special consideration in CKD patients.",
"The new oral anticoagulants have relatively little data in patients with severe renal impairment, and a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23026665",
"http://www.ncbi.nlm.nih.gov/pubmed/23631188",
"http://www.ncbi.nlm.nih.gov/pubmed/22177763",
"http://www.ncbi.nlm.nih.gov/pubmed/22931521",
"http://www.ncbi.nlm.nih.gov/pubmed/19712596",
"http://www.ncbi.nlm.nih.gov/pubmed/19196845",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007668",
"http://www.biosemantics.org/jochem#4243836"
] |
52bf1dea03868f1b06000012 | list | What are the side effects of Nalmefene? | [
"Side effects of nalmefene include nausea, dizziness / lightheadedness, insomina, fatigue, vomiting, reduced caloric intake / apetite, increased self-rated alertness and decreased tiredness. In horses some passage of semifluid fecal material, intermittent penile relaxation, and mild sedation has been described. In ... | [
"nausea",
"dizziness / lightheadedness",
"insomnia",
"fatigue",
"vomiting",
"reduced caloric intake / apetite",
"increased self-rated alertness",
"decreased tiredness",
"(horses) some passage of semifluid fecal material",
"(horses) intermittent penile relaxation",
"(horses) mild sedation"
] | [
"Adverse experiences included nausea, dizziness, and insomnia.",
"Side effects to nalmefene were of greater duration and intensity in the subjects receiving 10 mg of nalmefene vs. those receiving 6 or 2 mg. These included most notably fatigue, lightheadedness, nausea and vomiting.",
"The nalmefene treated group... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16379031",
"http://www.ncbi.nlm.nih.gov/pubmed/3826875",
"http://www.ncbi.nlm.nih.gov/pubmed/3680580",
"http://www.ncbi.nlm.nih.gov/pubmed/3943269",
"http://www.ncbi.nlm.nih.gov/pubmed/2315439",
"http://www.ncbi.nlm.nih.gov/pubmed/16449486"
] | [
{
"p": "http://data.linkedct.org/resource/linkedct/intervention_id",
"s": "http://data.linkedct.org/resource/intervention/43798",
"o": "43798"
},
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://data.linkedct.org/resource/intervention/43798",
"o": "Intervention #43798 (D... | [
"http://www.biosemantics.org/jochem#4258016"
] |
55001420e9bde69634000005 | yesno | Is Hirschsprung disease one of the characteristics of the Mowat-Wilson syndrome? | [
"Mowat-Wilson syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, congenital heart disease, agenesis of the corpus callosum, and eye defects.",
"Mowat-Wilson syndrome (MWS) i... | [
"yes"
] | [
"Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung d... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15908750",
"http://www.ncbi.nlm.nih.gov/pubmed/17958891",
"http://www.ncbi.nlm.nih.gov/pubmed/21893004",
"http://www.ncbi.nlm.nih.gov/pubmed/24282181",
"http://www.ncbi.nlm.nih.gov/pubmed/22486326",
"http://www.ncbi.nlm.nih.gov/pubmed/19302864",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:10487",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006627"
] |
530cf4d5e2bfff940c000004 | list | Which are the most common methods for gene prioritization analysis? | [
"Functional annotation-based approaches and literature-based approaches have been initially used. In recent years, network-based methods - which utilize a knowledge network derived from biological knowledge - have been utilized for gene prioritization. Currently network-based methods are the ones most widely used."... | [
"network-based methods"
] | [
"We developed a new network inference algorithm called the Knowledge Network Gene Prioritization (KNGP) algorithm which can incorporate both link and node knowledge",
" In recent years, network-based methods - which utilize a knowledge network derived from biological knowledge - have been utilized for gene priori... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24260251",
"http://www.ncbi.nlm.nih.gov/pubmed/23028459",
"http://www.ncbi.nlm.nih.gov/pubmed/23434623",
"http://www.ncbi.nlm.nih.gov/pubmed/17646288",
"http://www.ncbi.nlm.nih.gov/pubmed/24110485",
"http://www.ncbi.nlm.nih.gov/pubmed/23633938",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011506",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005796",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008722"
] |
513ce494bee46bd34c000009 | factoid | Which is the most common disease attributed to malfunction or absence of primary cilia? | [
"When ciliary function is perturbed, photoreceptors may die, kidney tubules develop cysts, limb digits multiply and brains form improperly. Mice display abnormalities very similar to those of patients with neonatal diabetes and hypothyroidism syndrome, including the development of diabetes and polycystic kidney dis... | [
"Polycystic kidney disease (PKD)"
] | [
"role of primary cilia in autosomal dominant polycystic kidney disease",
"Recent research has focused on defects in signaling mediated by the primary cilia as the causative factor in ADPKD",
"Interestingly, primary cilia concentrate p75NTR receptors in their membranes and are abnormally structured/damaged in tr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19276629",
"http://www.ncbi.nlm.nih.gov/pubmed/14978161",
"http://www.ncbi.nlm.nih.gov/pubmed/19186246",
"http://www.ncbi.nlm.nih.gov/pubmed/14983006",
"http://www.ncbi.nlm.nih.gov/pubmed/21439862",
"http://www.ncbi.nlm.nih.gov/pubmed/18407555",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0031514",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0035058",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0031512",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0031513"
] |
553cf397f321868558000010 | summary | What is the usefulness of ultraconserved elements in phylogeny? | [
"Because orthologous UCEs can be obtained from a wide array of taxa, are polymorphic at shallow evolutionary timescales, and can be generated rapidly at low cost, they are an effective genetic marker for studies investigating evolutionary patterns and processes at shallow timescales",
"Ultraconserved elements and... | [] | [
"Target capture and massively parallel sequencing of ultraconserved elements for comparative studies at shallow evolutionary time scales",
"Here, we evaluate the efficacy of genomic markers targeting ultraconserved DNA elements (UCEs) for analyses at shallow evolutionary timescales",
"Because orthologous UCEs c... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22593086",
"http://www.ncbi.nlm.nih.gov/pubmed/23824177",
"http://www.ncbi.nlm.nih.gov/pubmed/23382987",
"http://www.ncbi.nlm.nih.gov/pubmed/24021724",
"http://www.ncbi.nlm.nih.gov/pubmed/22207614",
"http://www.ncbi.nlm.nih.gov/pubmed/22232343"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010802"
] |
56c86aa95795f9a73e000018 | factoid | Treprostinil is an analogue for which prostaglandin? | [
"Treprostinil is a prostaglandin I(2) (PGI(2)) analog."
] | [
"Prostaglandin I(2)"
] | [
"We investigated the effects of 3 conventional (iloprost, beraprost, and treprostinil) and 1 new (ONO-1301) PGI2 analogs, on the expression of MIP-1α expression in human monocytes.",
"PGI(2) analogues (iloprost, treprostinil and beraprost) significantly increased IL-17A and IL-22 in vitro while decreasing IFNγ pr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11897647",
"http://www.ncbi.nlm.nih.gov/pubmed/22480736",
"http://www.ncbi.nlm.nih.gov/pubmed/22918043",
"http://www.ncbi.nlm.nih.gov/pubmed/12082102",
"http://www.ncbi.nlm.nih.gov/pubmed/23328389",
"http://www.ncbi.nlm.nih.gov/pubmed/23597147",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A2784623",
"o": "C427248"
}
] | [
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4270950",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011453",
"http://www.biosemantics.org/jochem#4270950",
"http://www.biosemantics.org/jochem#4276246"
] |
5537766dbc4f83e82800000d | summary | Which are the characteristics of the Meier-Gorlin syndrome? | [
"The Meier-Gorlin syndrome is a rare autosomal recessive disorder, characterized by the association of bilateral microtia, aplasia or hypoplasia of the patellae, and severe pre- and postnatal growth retardation.",
"The Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder, characterized by bilateral ... | [] | [
"Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder characterized by primordial dwarfism, microtia, and patellar aplasia/hypoplasia",
"The Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder, characterized by bilateral microtia, aplasia or hypoplasia of the patellae, and severe intr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23144622",
"http://www.ncbi.nlm.nih.gov/pubmed/21358631",
"http://www.ncbi.nlm.nih.gov/pubmed/14564153",
"http://www.ncbi.nlm.nih.gov/pubmed/21358632",
"http://www.ncbi.nlm.nih.gov/pubmed/23023959",
"http://www.ncbi.nlm.nih.gov/pubmed/7981855",
"http://www.ncbi.nlm.ni... | [] | [] |
571f5e740fd6f91b6800000b | factoid | Which enzyme is deficient in Gaucher's disease? | [
"Gaucher's disease is caused by deficient lysosomal glucocerebrosidase activity",
"Gaucher disease is an inborn recessive autosomal disease due to a partial deficiency of the lysosomal enzyme beta glucocerebrosidase. The deficient activity leads to accumulation of the lipid glucocerebroside in the liver, the sple... | [
"Beta glucocerebrosidase"
] | [
"Gaucher's disease is caused by deficient lysosomal glucocerebrosidase activity",
"Gaucher's disease is due to glucocerebrosidase deficiency which is responsible for the accumulation of non degraded glucosylceramide within the lysosomes of macrophages: these \"Gaucher cells\", overloaded and alternatively activat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21982627",
"http://www.ncbi.nlm.nih.gov/pubmed/20946052",
"http://www.ncbi.nlm.nih.gov/pubmed/17644022",
"http://www.ncbi.nlm.nih.gov/pubmed/18627336",
"http://www.ncbi.nlm.nih.gov/pubmed/20945983",
"http://www.ncbi.nlm.nih.gov/pubmed/22843412",
"http://www.ncbi.nlm.n... | [] | [] |
531881acb166e2b806000017 | summary | What is the role of Hsp90 inhibition in cancer therapy? | [
"Hsp90 inhibition is followed by G1/S cell cycle arrest, downregulation of key signalling proteins such as IGF-IR, Akt, IKK-α, IKK-β, FOXO1, ERK1/2 and c-Met, and sequestration-mediated inactivation of NF-κB, resulting in disruption of oncogenic signalling integrity, reduced cell proliferation, decline of cell moti... | [] | [
"Geldanamycin (GA) can be considered a relatively new component with a promising mode of action against human malignancies. It specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone.",
"In toto, we have evinced the dose-dependent and cell line-specific actions... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22134243",
"http://www.ncbi.nlm.nih.gov/pubmed/20828379",
"http://www.ncbi.nlm.nih.gov/pubmed/23394616",
"http://www.ncbi.nlm.nih.gov/pubmed/21964864",
"http://www.ncbi.nlm.nih.gov/pubmed/17525527"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009369",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030336",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051879",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:... |
55376f19bc4f83e82800000c | factoid | Which is the most common type of pediatric cerebellar tumor? | [
"Medulloblastoma is the most common malignant cerebellar tumor seen in the pediatric age group, which has a known ability to metastasize extraneurally.",
"Medulloblastoma is a malignant cerebellar tumor seen primarily in the pediatric age group that has a known ability to metastasize extraneurally "
] | [
"Medulloblastoma"
] | [
"Medulloblastoma (MDB) is the most common malignant cerebellar tumor in children",
"Medulloblastoma is a malignant cerebellar tumor seen primarily in the pediatric age group that has a known ability to metastasize extraneurally",
"Medulloblastoma (MB) is the most common malignant pediatric brain tumor which is ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21315459",
"http://www.ncbi.nlm.nih.gov/pubmed/23951168",
"http://www.ncbi.nlm.nih.gov/pubmed/25499213",
"http://www.ncbi.nlm.nih.gov/pubmed/6502196",
"http://www.ncbi.nlm.nih.gov/pubmed/21681603",
"http://www.ncbi.nlm.nih.gov/pubmed/16479172",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:5059",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002528"
] |
5319a7d2b166e2b806000029 | factoid | Which is the E3 ubiquitin ligase of Hsp90? | [
"Carboxyl terminus of hsc70-interacting protein (CHIP) can mediate ubiquitination of the 90 kDa heat-shock protein (hsp90) in vitro, with subsequent proteasomal degradation of the chaperone."
] | [
"Carboxyl terminus of hsc70-interacting protein (CHIP)"
] | [
"C-terminal Hsp-interacting protein (CHIP) is an HSP70 and HSP90 interacting co-chaperone and an E3 ubiquitin ligase. Previous studies have reported the role of CHIP in cancer progression by targeting protein degradation.",
"The U-box E3 ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein) binds Hsp90 ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23344957",
"http://www.ncbi.nlm.nih.gov/pubmed/17209571",
"http://www.ncbi.nlm.nih.gov/pubmed/20618441",
"http://www.ncbi.nlm.nih.gov/pubmed/23429937"
] | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000151",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051879",
"http://www.uniprot.org/uniprot/UB2E3_HUMAN",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004842",
"http://www.nlm.nih.gov/cgi/mesh/2... |
55439140ed966d112c00000a | list | Which are the major phycobiliproteins present in cyanobacteria? | [
"Phycobiliproteins are derived from the photosynthetic apparatus of cyanobacteria and eukaryotic algae, and form their large extrinsic antenna complexes called phycobilisomes. Phycobilisomes have a core composed from allophycocyanin (APC) and rods, which are of variable phycobiliprotein composition. C-Phycocyanin (... | [
"allophycocyanin (APC)",
"C-Phycocyanin (C-Pc)",
"B-Phycoerythrin (B-PE)",
"R-phycoerythrin (R-PE)"
] | [
"An extensive range of pigments including phycobiliproteins are present in algae. C-phycocyanin (C-PC), a phycobiliprotein, is one of the key pigments of Spirulina",
"Spirulina platensis produces nutraceutical product C-phycocyanin (C-PC)",
"C-Phycocyanin (C-Pc) is one of the major biliprotein pigments of unice... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15242812",
"http://www.ncbi.nlm.nih.gov/pubmed/18062815",
"http://www.ncbi.nlm.nih.gov/pubmed/16569506",
"http://www.ncbi.nlm.nih.gov/pubmed/2431391",
"http://www.ncbi.nlm.nih.gov/pubmed/1409666",
"http://www.ncbi.nlm.nih.gov/pubmed/24063013",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000458",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D052979"
] |
550c44d1a103b7801600000a | yesno | Is PLK2 involved in alpha-synuclein phosphorylation in the nervous system? | [
"Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in the central nervous system.",
"Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system "
] | [
"yes"
] | [
"Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system",
"Here we submit evidence that polo-like kinase 2 (PLK2, also known as serum-inducible kinase or SNK) is a principle contributor to alpha-synuclein phosphorylation at Ser-129 in neurons",
"PLK2 directly phosphoryl... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21162130",
"http://www.ncbi.nlm.nih.gov/pubmed/21838679",
"http://www.ncbi.nlm.nih.gov/pubmed/23983262",
"http://www.ncbi.nlm.nih.gov/pubmed/24128992",
"http://www.ncbi.nlm.nih.gov/pubmed/23794260",
"http://www.ncbi.nlm.nih.gov/pubmed/19004816"
] | [] | [
"http://www.uniprot.org/uniprot/SYUA_SERCA",
"http://www.uniprot.org/uniprot/SYUA_ERYPA",
"http://www.uniprot.org/uniprot/SYUA_GORGO",
"http://www.uniprot.org/uniprot/SYUA_PANPA",
"http://www.uniprot.org/uniprot/SYUA_ATEGE",
"http://www.uniprot.org/uniprot/SYUA_RAT",
"http://www.uniprot.org/uniprot/SYUA... |
5547a01cf35db75526000005 | factoid | In which kingdom do microsporidia belong, according to their current classification scheme? | [
"Traditionally, microsporidia were considered as protozoans, but recently they have been reclassified as the earliest-diverging clade of sequenced fungi. Microsporidia are a diverse group of obligate, intracellular, eukaryotic, spore-forming parasites; they are ubiquitous fungi, with genomes that have undergone a s... | [
"Fungi"
] | [
"Microsporidia are a diverse group of obligate, intracellular, eukaryotic, spore-forming parasites. Traditionally, these were considered as protozoans but recently have been reclassified as fungi. ",
"Microsporidia are ubiquitous fungi with genomes that have undergone a strong reduction",
"Microsporidia are uni... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23917025",
"http://www.ncbi.nlm.nih.gov/pubmed/25258042",
"http://www.ncbi.nlm.nih.gov/pubmed/22651672",
"http://www.ncbi.nlm.nih.gov/pubmed/24104931",
"http://www.ncbi.nlm.nih.gov/pubmed/20479876",
"http://www.ncbi.nlm.nih.gov/pubmed/24558617",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002965",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016814",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D021861"
] |
51656c94298dcd4e51000058 | list | What is the inheritance pattern of Emery-Dreifuss muscular dystrophy? | [
"The inheritance pattern of Emery-Dreifuss muscular dystrophy (EDMD) can be X-linked, autosomal dominant or autosomal recessive."
] | [
"X-linked",
"autosomal dominant",
"autosomal recessive"
] | [
". Loss-of-function truncation mutations in EMD, encoding the nuclear membrane protein emerin, cause X-linked Emery-Dreifuss muscular dystrophy (EDMD) characterized by localized contractures and skeletal myopathy in adolescence, sinus node dysfunction (SND) in early adulthood, and atrial fibrillation as a variably ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9536090",
"http://www.ncbi.nlm.nih.gov/pubmed/8445613",
"http://www.ncbi.nlm.nih.gov/pubmed/11799477",
"http://www.ncbi.nlm.nih.gov/pubmed/11863303",
"http://www.ncbi.nlm.nih.gov/pubmed/23349612",
"http://www.ncbi.nlm.nih.gov/pubmed/8042665",
"http://www.ncbi.nlm.nih.... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A17680512",
"o": "Emery-Dreifuss Muscular Dystrophy"
},
{
"p": "http://linkedlifedata.com/resource/umls/altMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C0410189",
"o"... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D040582",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020389",
"http://www.disease-ontology.org/api/metadata/DOID:655",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exa... |
51485a4dd24251bc0500002a | summary | What is the mechanism of action of anticoagulant medication Dabigatran? | [
"Dabigatran is orally administered, reverisble direct and competetive inhibitor of both free and bouded thrombin."
] | [] | [
"Dabigatran etexilate is a novel oral direct thrombin inhibitor, which provides stroke risk reduction for patients with nonvalvular atrial fibrillation. ",
"Dabigatran is a potent reversible, competitive direct thrombin inhibitor which is available as the prodrug, Dabigatran etexilate.",
"The recently introduce... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20589316",
"http://www.ncbi.nlm.nih.gov/pubmed/22388002",
"http://www.ncbi.nlm.nih.gov/pubmed/22480286",
"http://www.ncbi.nlm.nih.gov/pubmed/21666370",
"http://www.ncbi.nlm.nih.gov/pubmed/23466964",
"http://www.ncbi.nlm.nih.gov/pubmed/23031622",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D045504",
"http://www.biosemantics.org/jochem#4242811"
] |
56b710f276d8bf8d13000003 | factoid | What is the effect of a defective CLN3 gene? | [
"Mutations in the CLN3 gene, which encodes a lysosomal membrane protein, are responsible for the neurodegenerative disorder juvenile Batten disease."
] | [
"Batten disease",
"juvenile-onset neuronal ceroid lipofuscinosis",
"JNCL"
] | [
"Juvenile neuronal ceroid lipofuscinosis (Batten disease) is a neurodegenerative disorder caused by defective function of the lysosomal membrane glycoprotein CLN3. ",
"human CLN3 that is defective in Batten disease, localizes to the vacuole",
"JNCL results from mutations in CLN3 on chromosome 16p12.1.",
"Muta... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10332042",
"http://www.ncbi.nlm.nih.gov/pubmed/16251196",
"http://www.ncbi.nlm.nih.gov/pubmed/17868323",
"http://www.ncbi.nlm.nih.gov/pubmed/16423829",
"http://www.ncbi.nlm.nih.gov/pubmed/10384264",
"http://www.ncbi.nlm.nih.gov/pubmed/16515873",
"http://www.ncbi.nlm.n... | [
{
"p": "http://purl.uniprot.org/core/encodedBy",
"s": "http://purl.uniprot.org/uniprot/Q61124",
"o": "http://linkedlifedata.com/resource/#_5136313132340012"
},
{
"p": "http://www.w3.org/2004/02/skos/core#prefLabel",
"s": "http://linkedlifedata.com/resource/#_5136313132340012",
"o": "Cln3... | [
"http://www.uniprot.org/uniprot/CLN3_MOUSE",
"http://www.uniprot.org/uniprot/CLN3_MACFA",
"http://www.uniprot.org/uniprot/CLN3_HUMAN",
"http://www.uniprot.org/uniprot/CG13_YEAST",
"http://www.uniprot.org/uniprot/CLN3_DICDI",
"http://www.uniprot.org/uniprot/CLN3_CANFA"
] |
517539ca8ed59a060a000027 | list | Which genes are regulated by TRalpha2 in the heart? | [
"ARB1, ARB2, TAK1, p38, TRalpha1"
] | [
"ARB1",
"ARB2",
"TAK1",
"p38",
"TRalpha1"
] | [
"n FM the reduced mRNA expression of ARB1 (p<0.05, -37%) and ARB2 (p<0.05, -42%) was associated with a reduction of the messenger for TRalpha1 (p<0.05, -85%) and TRalpha2 (p<0.05, -73%).",
"hese data reveal that in human heart failure the reduction of beta-adrenergic receptors is associated with reduced expressio... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11731613",
"http://www.ncbi.nlm.nih.gov/pubmed/18031713",
"http://www.ncbi.nlm.nih.gov/pubmed/15831522"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006321",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009206",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005796"
] |
54e12ae3ae9738404b000004 | yesno | Is insulin-like growth factor-I (IGF-I) able to affect tendon protein synthesis in classic Ehlers-Danlos syndrome patients? | [
"Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I ",
"In an experimental setting, baseline protein synthesis rates in connective tissue appeared normal in classic Ehlers-Danlos syndrome patients, and the patients responded with an increased tendo... | [
"yes"
] | [
"Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I",
"IGF-I injections significantly increased FSR values in cEDS patients but not in controls",
"In conclusion, baseline protein synthesis rates in connective tissue appeared normal in cEDS patient... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25103963"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:13359",
"http://www.uniprot.org/uniprot/IGF_MYXGL",
"http://www.uniprot.org/uniprot/IGF1_CAPHI"
] |
554143ad182542114d000004 | list | List available methods for transmembrane protein topology prediction. | [
"HMMpTM, MetaTM, Philius, HMM_RA, HMMTOP, MEMSAT3, HMM-TM, TMHMM, Phobius and SignalP."
] | [
"HMMpTM",
"MetaTM",
"Philius",
"HMM_RA",
"HMMTOP",
"MEMSAT3",
"HMM-TM",
"TMHMM",
"Phobius",
"SignalP"
] | [
"HMMpTM: improving transmembrane protein topology prediction using phosphorylation and glycosylation site prediction",
"We report the development of a Hidden Markov Model based method, capable of predicting the topology of transmembrane proteins and the existence of kinase specific phosphorylation and N/O-linked ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19470175",
"http://www.ncbi.nlm.nih.gov/pubmed/18989393",
"http://www.ncbi.nlm.nih.gov/pubmed/19812766",
"http://www.ncbi.nlm.nih.gov/pubmed/16568545",
"http://www.ncbi.nlm.nih.gov/pubmed/24225132",
"http://www.ncbi.nlm.nih.gov/pubmed/11590105",
"http://www.ncbi.nlm.n... | [] | [] |
55422640ccca0ce74b000004 | yesno | Does GC content vary markedly within a given isochore? | [
"Isochores are relatively long regions with a relatively homogeneous GC content, and with rather sharp boundaries with neighboring isochores. The base composition, and thus the GC content may differ between different isochores, but is more or less consistent within a given isochore."
] | [
"no"
] | [
"The isochore, a large DNA sequence with relatively small GC variance, is one of the most important structures in eukaryotic genomes.",
"Isochores are large regions of relatively homogeneous nucleotide composition",
"Vertebrate genomes are comprised of isochores that are relatively long (>100 kb) regions with a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18092827",
"http://www.ncbi.nlm.nih.gov/pubmed/17317955",
"http://www.ncbi.nlm.nih.gov/pubmed/22934101",
"http://www.ncbi.nlm.nih.gov/pubmed/15978039",
"http://www.ncbi.nlm.nih.gov/pubmed/19443854",
"http://www.ncbi.nlm.nih.gov/pubmed/11591467",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001482",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D032085"
] |
5317606eb166e2b80600000d | yesno | Is tubulin acetylation involved in cell motility? | [
"Yes, induction of alpha-tubulin acetylation correlates with inhibition of cell motility, while it is involved in additional cellular processes, e.g. cell cycle progression, differentiation, intracellular trafficking, and signalling. Dynamic microtubule (MT) acetylation/deacetylation mediating cell motility and adh... | [
"yes"
] | [
"In this study, we found that paclitaxel induced tubulin acetylation in endothelial and tumor cells, at concentrations that affected cell motility but not proliferation (10(-8) to 10(-9) M, for 4 hours). Induction of tubulin acetylation correlated with inhibition of motility but not proliferation based on a compari... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22193721",
"http://www.ncbi.nlm.nih.gov/pubmed/20308065",
"http://www.ncbi.nlm.nih.gov/pubmed/23019416",
"http://www.ncbi.nlm.nih.gov/pubmed/12024216",
"http://www.ncbi.nlm.nih.gov/pubmed/22589388",
"http://www.ncbi.nlm.nih.gov/pubmed/20940043",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054443",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007021",
"http://www.uniprot.org/uniprot/TBA_GIBZE",
"http://www.nlm.nih.... |
56b739d976d8bf8d13000005 | list | List available genetic multicolor cell labeling techiniques in Drosophila | [
"Flybow and Drosophila Brainbow."
] | [
"Flybow",
"Drosophila Brainbow"
] | [
"Flybow: genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster.",
"To facilitate studies of neural network architecture and formation, we generated three Drosophila melanogaster variants of the mouse Brainbow-2 system, called Flybow. Sequences encoding different membrane-tethered... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25657347",
"http://www.ncbi.nlm.nih.gov/pubmed/21297621",
"http://www.ncbi.nlm.nih.gov/pubmed/21297619"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004330",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004331",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007553"
] |
5319abffb166e2b80600002f | list | Which growth factors are known to be involved in the induction of EMT? | [
"EMT is characterized by acquisition of cell motility, modifications of cell morphology, and cell dissociation correlating with the loss of desmosomes from the cellular cortex. A number of growth factors have been shown to be involved in this process. These include fibroblast growth factors (FGFs), TGF-β1, TGF-β2, ... | [
"fibroblast growth factors (FGFs)",
"TGF-β1",
"TGF-β2",
"TNF-α",
"CCN family",
"Sonic Hedgehog (SHh)",
"Notch1",
"GF-β",
"Wnt",
"EGF",
"bFGF",
"IGF-I",
"IGF-II"
] | [
"Moreover, recent studies have shown that most EMT cases are regulated by soluble growth factors or cytokines. Among these factors, fibroblast growth factors (FGFs) execute diverse functions by binding to and activating members of the FGF receptor (FGFR) family, including FGFR1-4.",
"Fibroblast growth factor rece... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23027863",
"http://www.ncbi.nlm.nih.gov/pubmed/23437179",
"http://www.ncbi.nlm.nih.gov/pubmed/17720949",
"http://www.ncbi.nlm.nih.gov/pubmed/22547830",
"http://www.ncbi.nlm.nih.gov/pubmed/16365168",
"http://www.ncbi.nlm.nih.gov/pubmed/21680037",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070848",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005346",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019838",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:... |
51600ca2298dcd4e51000037 | summary | What is the function of the yeast protein Aft1? | [
"The Aft1 transcription factor regulates the iron regulon in response to iron availability in Saccharomyces cerevisiae. Aft1 activates a battery of genes required for iron uptake under iron-starved conditions, whereas Aft1 function is inactivated under iron-replete conditions. Aft1 interacts with the FOB (ferrioxa... | [] | [
"Using a scheme for selecting mutants of Saccharomyces cerevisiae with abnormalities of iron metabolism, we have identified a gene, AFT1, that mediates the control of iron uptake",
"AFT1 functions to activate transcription of target genes in response to iron deprivation and thereby plays a central role in iron ho... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8670839",
"http://www.ncbi.nlm.nih.gov/pubmed/11877447",
"http://www.ncbi.nlm.nih.gov/pubmed/16024809",
"http://www.ncbi.nlm.nih.gov/pubmed/21542867",
"http://www.ncbi.nlm.nih.gov/pubmed/17096368",
"http://www.ncbi.nlm.nih.gov/pubmed/14739928",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.uniprot.org/uniprot/AFT1_YEAST"
] |
5148e42cd24251bc0500003b | yesno | Can PLN mutations lead to dilated cardiomyopathy? | [
"Yes, PLN mutations can lead to dilated cardiomyopathy."
] | [
"yes"
] | [
"A PLN founder mutation (43 cases) and LMNA mutations (19 cases, 16 different mutations) were most prevalent and often demonstrated a specific phenotype.",
"PLN mutation R14del was identified in 12 (12 %) ARVC patients and in 39 (15 %) DCM patients",
"The PLN R14del founder mutation is present in a substantial ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20634894",
"http://www.ncbi.nlm.nih.gov/pubmed/22137083",
"http://www.ncbi.nlm.nih.gov/pubmed/15336969",
"http://www.ncbi.nlm.nih.gov/pubmed/15769782",
"http://www.ncbi.nlm.nih.gov/pubmed/23349452",
"http://www.ncbi.nlm.nih.gov/pubmed/21282613",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A17851795",
"o": "Dilated cardiomyopathy"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A0035199",
"o": "Cardiomyop... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017354",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004106",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018389",
"http://www.uniprot.org/uniprot/PP... |
5319a6e9b166e2b806000023 | factoid | Which is the genetic lesion associated with Huntington’s disease? | [
"The genetic lesion associated with Huntington's disease is a CAG trinucleotide repeat expansion in the HD (or HTT) gene."
] | [
"A CAG trinucleotide repeat expansion in the HD gene"
] | [
"Early in 1993, an unstable, expanded trinucleotide repeat in a novel gene of unknown function was identified on HD chromosomes. This discovery unleased a flurry of experimentation that has established the expanded CAG repeat the almost universal cause of the characteristic neurologic symptoms and pathology of this... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7620118"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D030342",
"http://www.disease-ontology.org/api/metadata/DOID:12858",
"http://www.disease-ontology.org/api/metadata/DOID:0050739",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006816",
"htt... |
5314896adae131f847000001 | yesno | Is corpus callosum involved in the Mowat–Wilson syndrome? | [
"Yes, agenesis of the corpus callosum is common patients with Mowat–Wilson syndrome. Other characteristic features of Mowat–Wilson syndrome include typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, conge... | [
"yes"
] | [
" The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, congenital heart disease, agenesis of the corpus callosum, and eye defects. ",
"Mowat-Wilson syndrome in a fetus wit... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17958891",
"http://www.ncbi.nlm.nih.gov/pubmed/23531534",
"http://www.ncbi.nlm.nih.gov/pubmed/19842203",
"http://www.ncbi.nlm.nih.gov/pubmed/15065106",
"http://www.ncbi.nlm.nih.gov/pubmed/17203459",
"http://www.ncbi.nlm.nih.gov/pubmed/23523603",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003337",
"http://www.disease-ontology.org/api/metadata/DOID:225"
] |
56c703445795f9a73e00000a | list | Which histone modification discriminates between active and poised enhancers? | [
"Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and on enhancers. "
] | [
"H3K4me1",
"H3K27ac"
] | [
"Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and on enhancer",
"Since Trr and mammalian Mll3/4 complexes are distinguished by bearing a unique subunit, the H3K27 de... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21632746",
"http://www.ncbi.nlm.nih.gov/pubmed/25614629",
"http://www.ncbi.nlm.nih.gov/pubmed/23595227",
"http://www.ncbi.nlm.nih.gov/pubmed/24038352",
"http://www.ncbi.nlm.nih.gov/pubmed/23880941",
"http://www.ncbi.nlm.nih.gov/pubmed/23166019",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0016570",
"http://www.biosemantics.org/jochem#4278518",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006657",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D042421"
] |
56c344abfedd0b786b000003 | list | What are the properties of super-enhancers? | [
"Super-enhancers differ from typical enhancers in size, transcription factor density and content, ability to activate transcription, and sensitivity to perturbation. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with ... | [
"their magnitude of size",
"transcription factor density",
"binding of transcriptional machinery",
"associated with genes driving cell differentiation"
] | [
"Here we report that enhancer RNAs (eRNAs) identified by global nuclear run-on sequencing are extensively transcribed within super enhancers and are dynamically regulated in response to cellular signaling.",
"Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs",
"The expr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25686607",
"http://www.ncbi.nlm.nih.gov/pubmed/25799994",
"http://www.ncbi.nlm.nih.gov/pubmed/25650801",
"http://www.ncbi.nlm.nih.gov/pubmed/24119843",
"http://www.ncbi.nlm.nih.gov/pubmed/26569311",
"http://www.ncbi.nlm.nih.gov/pubmed/25263595",
"http://www.ncbi.nlm.n... | [] | [] |
52bf208003868f1b06000019 | factoid | What is the inheritance pattern of Li–Fraumeni syndrome? | [
"Li-Fraumeni syndrome shows autosomal dominant inheritance."
] | [
"Autosomal dominant"
] | [
"It therefore appears that the LFS phenotype has been conferred by an aberrant gene, showing a dominant pattern of inheritance, which may be acting to compromise normal p53 function rather than by a mutation in p53 itself.",
"In addition, there seem to be predispositions to a wider range of different, but well-de... | [
"http://www.ncbi.nlm.nih.gov/pubmed/2190528",
"http://www.ncbi.nlm.nih.gov/pubmed/7981072",
"http://www.ncbi.nlm.nih.gov/pubmed/16772121",
"http://www.ncbi.nlm.nih.gov/pubmed/9302689",
"http://www.ncbi.nlm.nih.gov/pubmed/22672556",
"http://www.ncbi.nlm.nih.gov/pubmed/20075382"
] | [
{
"p": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/diseaseSubtypeOf",
"s": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/2961",
"o": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/679"
},
{
"p": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/di... | [
"http://www.disease-ontology.org/api/metadata/DOID:3012",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"http://www.disease-ontology.org/api/metadata/DOID:225",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016864"
] |
514a51c2d24251bc0500005c | factoid | Which pituitary adenoma is common cause of infertility is women? | [
"Prolactinoma is a pituitary adenoma that is strongly associated with infertility in women mainly due to increased prolactin secretion causing hyperprolactinemia. Other pituitary lesions can also be associated with infertility."
] | [
"prolactinoma"
] | [
"Prolactinoma is the most common secreting pituitary adenoma. It is typically diagnosed in women of reproductive age and is common cause of infertility.",
"Examination of the tissue excised by transsphenoidal excision of the mass showed a pituitary adenoma that stained strongly for FSH. RESULTS: Regular menses re... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9152623",
"http://www.ncbi.nlm.nih.gov/pubmed/23090264",
"http://www.ncbi.nlm.nih.gov/pubmed/2803131",
"http://www.ncbi.nlm.nih.gov/pubmed/12477530",
"http://www.ncbi.nlm.nih.gov/pubmed/2738821",
"http://www.ncbi.nlm.nih.gov/pubmed/10649814",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014930",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015175",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007247",
"http://www.nlm.nih.gov/cgi/mesh/2... |
553e07caf321868558000016 | summary | What is the role of mismatched uracil glycosylase (Mug) in DNA repair? | [
"The mismatch-specific uracil DNA glycosylase (MUG) belongs to a homologous family of DNA glycosylases that initiate base-excision repair of G:U/T mismatches. The crystal structure of the Mug repair complex points to a preference of Mug for G:U over G:T mispairs. Nonetheless, Mug does not repair U:G or T:G mismatch... | [] | [
"XDG activity is attributable to MUG",
"xanthine DNA glycosylase (XDG) activity in E. coli",
"The wild type MUG possesses more robust activity against xanthine than uracil and is active against all xanthine-containing DNA",
"The gene for the mismatch-specific uracil DNA glycosylase (MUG) was identified in the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12016206",
"http://www.ncbi.nlm.nih.gov/pubmed/11841206",
"http://www.ncbi.nlm.nih.gov/pubmed/21112870",
"http://www.ncbi.nlm.nih.gov/pubmed/15474419",
"http://www.ncbi.nlm.nih.gov/pubmed/9699633",
"http://www.ncbi.nlm.nih.gov/pubmed/11555290",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.uniprot.org/uniprot/MUG_SHIBS",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004844",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053843",
"http://www.nlm.nih.... |
534bb147aeec6fbd07000014 | list | Which are the cardiac effects of thyronamines? | [
"Thyronamines have negative chronotropy, negative inotropy; in particular thyronamines are considered negative inotropic agents",
"In the heart, thyronamines cause negative chronotropy, negative inotropy,reduced cardiac output and resistance to ischemic injury."
] | [
"negative chronotropy",
"lower heart rate",
"negative inotropy",
"negative inotropism",
"resistance to ischemic injury",
"reduced cardiac output"
] | [
"Most recently, thyroid hormone derivatives were identified, the thyronamines which are decarboxylated thyroid hormones initiating physiological actions like lowering body temperature and heart rate, thereby acting in opposite direction to the classical thyroid hormones.",
"Intraperitoneal or central injection of... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18954857",
"http://www.ncbi.nlm.nih.gov/pubmed/17579492",
"http://www.ncbi.nlm.nih.gov/pubmed/21835056",
"http://www.ncbi.nlm.nih.gov/pubmed/19016324",
"http://www.ncbi.nlm.nih.gov/pubmed/20880963",
"http://www.ncbi.nlm.nih.gov/pubmed/17204552",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006331",
"http://www.biosemantics.org/jochem#4251308",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006321",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&ter... |
55086ea1098a1b487b000001 | list | Matuzumab has been tested for treatment of which cancers? | [
"Matuzumab has been tested for treatment of non-small cell lung, gastric, esophageal, colorectal, primary peritoneal, pancreatic, ovarian and cervical cancers."
] | [
"non-small cell lung",
"gastric",
"esophageal",
"colorectal",
"primary peritoneal",
"pancreatic",
"ovarian",
"cervical"
] | [
" Matuzumab and panitumumab have also been studied in phase II trials.",
"A phase I pharmacokinetic study of matuzumab in combination with paclitaxel in patients with EGFR-expressing advanced non-small cell lung cancer.",
"This phase I study investigated the tolerability, safety and pharmacokinetics (PK) of mat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17671148",
"http://www.ncbi.nlm.nih.gov/pubmed/18181050",
"http://www.ncbi.nlm.nih.gov/pubmed/17126894",
"http://www.ncbi.nlm.nih.gov/pubmed/19482958",
"http://www.ncbi.nlm.nih.gov/pubmed/16857825",
"http://www.ncbi.nlm.nih.gov/pubmed/22763610",
"http://www.ncbi.nlm.n... | [] | [] |
5171651e8ed59a060a000009 | list | Which are the synonyms of prostate-specific antigen? | [
"Prostate-specific antigen (PSA) is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases which is produced by epithelial cells of both normal and malignant prostate tissue. PSA is an important marker for the diagnosis of prostate cancer. PSA is also known as human kallikrein-rel... | [
"human kallikrein-related peptidase 3",
"hK3"
] | [
"Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain.",
"Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/19079621"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020840",
"http://www.uniprot.org/uniprot/KLK2_CAVPO",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017430",
"http://www.uniprot.org/uniprot/KLK3_MACFA",
"http://www.uniprot.org/uniprot/KL... |
56b397a98525abca1e000003 | factoid | What is the lipid droplet used for in the cell? | [
"Lipid droplets (LDs) are ubiquitous and physiologically active organelles regulating storage and mobilization of lipids in response to metabolic demands."
] | [
"lipid storage and lipid mobilization"
] | [
"Eukaryotic cells store excess fatty acids as neutral lipids, predominantly triacylglycerols and sterol esters, in organelles termed lipid droplets (LDs) that bulge out from the endoplasmic reticulum. ",
"Lipid droplets (LD) are spherical cellular inclusion devoted to lipids storage.",
"Cells store fatty acids ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26121906",
"http://www.ncbi.nlm.nih.gov/pubmed/25189622",
"http://www.ncbi.nlm.nih.gov/pubmed/25132820",
"http://www.ncbi.nlm.nih.gov/pubmed/24394544",
"http://www.ncbi.nlm.nih.gov/pubmed/25894691",
"http://www.ncbi.nlm.nih.gov/pubmed/25110833"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A12002602",
"o": "MTHU008985"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#prefLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1848739",
"o": "http://linkedlifedata.com/re... | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005811",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D066292",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034389",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+... |
56c58ceeb04e159d0e000004 | factoid | What is the function of circular RNA? | [
"Circular RNAs (circRNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. The biogenesis of circular RNA is an integral, conserved, and regulated feature of the gene expression program. Circular RNAs play a crucia... | [
"Recent research has revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression."
] | [
"Here we determine the structure of these novel transcripts, showing that they correspond to circular RNA molecules containing only exons in genomic order.",
"Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle.",
... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24339831",
"http://www.ncbi.nlm.nih.gov/pubmed/26052092",
"http://www.ncbi.nlm.nih.gov/pubmed/24039610",
"http://www.ncbi.nlm.nih.gov/pubmed/24609083",
"http://www.ncbi.nlm.nih.gov/pubmed/25404635",
"http://www.ncbi.nlm.nih.gov/pubmed/7678559"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012313",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D035683"
] |
54d62faf3706e89528000003 | yesno | Can NXY-059 be used for treatment of acute ischemic stroke patients? | [
"No. 2,4-disulfonylphenyl PBN derivative, called NXY-059 in the stroke studies, was shown to be safe in humans and was taken all the way through clinical phase 3 trials and then was deemed to be ineffective."
] | [
"no"
] | [
"Even when the international recommendations for preclinical stroke research, the Stroke Academic Industry Roundtable (STAIR) criteria, were followed, we have still seen limited success in the clinic, examples being NXY-059 and haematopoietic growth factors which fulfilled nearly all the STAIR criteria",
"This oc... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17408618",
"http://www.ncbi.nlm.nih.gov/pubmed/21651461",
"http://www.ncbi.nlm.nih.gov/pubmed/11239186",
"http://www.ncbi.nlm.nih.gov/pubmed/18369171",
"http://www.ncbi.nlm.nih.gov/pubmed/19167593",
"http://www.ncbi.nlm.nih.gov/pubmed/17975102",
"http://www.ncbi.nlm.n... | [] | [] |
56bb6b0eac7ad1001900000e | yesno | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | [
"Yes, flibanserin, a novel serotonin (5-HT)(1A) agonist and 5-HT(2A) antagonist, has been shown to increase sexual desire and reduce distress in women with Hypoactive Sexual Desire Disorder."
] | [
"yes"
] | [
"Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder.",
"Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest an... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20646181",
"http://www.ncbi.nlm.nih.gov/pubmed/23421417",
"http://www.ncbi.nlm.nih.gov/pubmed/25659981",
"http://www.ncbi.nlm.nih.gov/pubmed/25187905",
"http://www.ncbi.nlm.nih.gov/pubmed/24281236",
"http://www.ncbi.nlm.nih.gov/pubmed/22727480"
] | [] | [
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4266735",
"http://www.biosemantics.org/jochem#4266735",
"http://www.disease-ontology.org/api/metadata/DOID:13868"
] |
55414c65472cfd8617000001 | list | List available biomedical question answering systems. | [
"We live in an age of access to more information than ever before. The exponential growth in the volume of publications in the biomedical domain has made it impossible for an individual to keep pace with the advances. Thus, there is a need for intelligent information retrieval systems that can summarize relevant an... | [
"askHERMES",
"EAGLi",
"HONQA",
"INDOC"
] | [
"Question answering is a specialized type of information retrieval with the aim of returning precise short answers to queries posed as natural language questions. We present a review and comparison of three biomedical question answering systems: askHERMES (http://www.askhermes.org/), EAGLi (http://eagl.unige.ch/EAG... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17990503",
"http://www.ncbi.nlm.nih.gov/pubmed/23244628",
"http://www.ncbi.nlm.nih.gov/pubmed/18274647"
] | [] | [] |
517a8c238ed59a060a000042 | list | Which dediodinases are present in kidney? | [
"Type 1 and Type 3 deiodinases are both present in liver"
] | [
"Type 1 deiodinase",
"Tipe 3 deiodinase"
] | [
"Iodothyronine deiodinase in vitro activity studies in the chicken showed the presence of type I and type III iodothyronine deiodinase activity in both liver and kidney.",
"Co-expression of the deiodinases was also found in the kidney.",
"high ID-I activities were found in liver, kidney",
"the kidney microsom... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15072569",
"http://www.ncbi.nlm.nih.gov/pubmed/9794474",
"http://www.ncbi.nlm.nih.gov/pubmed/3595535",
"http://www.ncbi.nlm.nih.gov/pubmed/7768329",
"http://www.ncbi.nlm.nih.gov/pubmed/3197644"
] | [] | [] |
54edf72c94afd61504000013 | factoid | What is the presumed key event in Fanconi anemia pathogenesis? | [
"Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links. Failure of FANCD2 monoubiquitination by the nuclear FA protein complex has a severe impact on the DNA repair functions of cells."
] | [
"FANCD2 monoubiquitination"
] | [
"A key event in FA pathway activation is the monoubiquitylation of the FA complementation group I (FANCI)-FANCD2 (ID) complex by FA complementation group L (FANCL), an E3 ubiquitin ligase",
"Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links",
"H... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22675617",
"http://www.ncbi.nlm.nih.gov/pubmed/15601828",
"http://www.ncbi.nlm.nih.gov/pubmed/19609304",
"http://www.ncbi.nlm.nih.gov/pubmed/20937699",
"http://www.ncbi.nlm.nih.gov/pubmed/15502827",
"http://www.ncbi.nlm.nih.gov/pubmed/22258451",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051856",
"http://www.disease-ontology.org/api/metadata/DOID:13636",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005199",
"http://www.disease-ontology.org/api/metadata/DOID:1062"
] |
515df1d4298dcd4e5100002b | summary | What is the effect of Allopurinol on asphyxia in neonates? | [
"Allopurinol was shown in a number of clinical trial to be safe and effective for treatment of neonatal asphyxia. Allopurinol improves short-term and long-term clinical outcomes of neonatal asphyxia. Allopurinol should be administered as soon as possible. Postulated mechanism of allopurinol action in this setting ... | [] | [
"Potential neuroprotective strategies targeting different pathways leading to neuronal cell death in response to hypoxic-ischemic insult have been investigated: hypothermia, erythropoietin, iminobiotin, deferioxamine, magnesium, allopurinol, xenon, melatonin and statins.",
"Allopurinol reduces the formation of fr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16428356",
"http://www.ncbi.nlm.nih.gov/pubmed/17162192",
"http://www.ncbi.nlm.nih.gov/pubmed/22564301",
"http://www.ncbi.nlm.nih.gov/pubmed/22102633",
"http://www.ncbi.nlm.nih.gov/pubmed/9445490",
"http://www.ncbi.nlm.nih.gov/pubmed/16778717",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001238",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001237",
"http://www.biosemantics.org/jochem#4273300",
"http://www.disease-ontology.org/api/metadata/DOID:11088",
"http://www.nlm.nih... |
53267871d6d3ac6a3400000a | yesno | Is recommended the use of perioperative treatment with thyroid hormone therapy in patients undergoing coronary artery bypass grafting? | [
"Currently there is no substantial evidence to justify routine use of thyroid hormones in patients undergoing coronary artery bypass grafting."
] | [
"no"
] | [
"Short duration postoperative iv T(3) therapy increases cardiac index and does not alter mortality.",
"We conclude that although widespread interest has been shown on the use of thyroid hormones in the perioperative period, and the effect of cardiopulmonary bypass on thyroid hormone metabolism widely studied, the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7477166",
"http://www.ncbi.nlm.nih.gov/pubmed/20668034",
"http://www.ncbi.nlm.nih.gov/pubmed/14500064",
"http://www.ncbi.nlm.nih.gov/pubmed/12213743",
"http://www.ncbi.nlm.nih.gov/pubmed/12643405",
"http://www.ncbi.nlm.nih.gov/pubmed/8633935",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003324",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D047549",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013963",
"http://www.nlm.nih.gov/cgi/mesh/2... |
56e844c442442bac75000002 | summary | When is the protein NFL a biomarker? | [
"Neurofilament light protein (NFL), may be released into the cerebrospinal fluid (CSF) during pathological processes in the central nervous system (CNS).\nNeurofilament light chain is a prognostic biomarker in neurological disorders such as amyotrophic lateral sclerosis, frontotemporal degeneration, axonal injury, ... | [] | [
"Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.",
"CSF neurofilament light chain reflects corticospinal tract degeneration in ALS.",
"Raised neurofilament light chain protein (NfL) in cerebrospinal fluid (CSF) is thought to reflect axonal damage in a range of neurological di... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24571714",
"http://www.ncbi.nlm.nih.gov/pubmed/24479774",
"http://www.ncbi.nlm.nih.gov/pubmed/24242746",
"http://www.ncbi.nlm.nih.gov/pubmed/24073237",
"http://www.ncbi.nlm.nih.gov/pubmed/23529999",
"http://www.ncbi.nlm.nih.gov/pubmed/16894110",
"http://www.ncbi.nlm.n... | [] | [] |
56e68967edfc094c1f000002 | yesno | Is protein CXCR4 used as a prognostic marker of cancer? | [
"Yes, the chemokine C-X-C motif receptor 4 (CXCR4) has been found to be a prognostic marker in various types of cancer."
] | [
"yes"
] | [
"Aberrant overexpression of CXCR4 is associated with worse overall survival, adenocarcinoma histology, distant metastasis, lymph node involvement in NSCLC.",
"CXCR4 belongs to a family of G protein-coupled cell surface receptors and has been proved to a prognostic marker in a various tumors, including esophageal ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20061818",
"http://www.ncbi.nlm.nih.gov/pubmed/23822165",
"http://www.ncbi.nlm.nih.gov/pubmed/23650783",
"http://www.ncbi.nlm.nih.gov/pubmed/22473623",
"http://www.ncbi.nlm.nih.gov/pubmed/21234386",
"http://www.ncbi.nlm.nih.gov/pubmed/22075627",
"http://www.ncbi.nlm.n... | [] | [] |
5159a306d24251bc050000a1 | summary | How does thyroid hormone regulate SR-Ca2+ ATPase (SERCA) protein in the heart? | [
"The thyroid hormone (TH) induced regulation of SERCA is mediated both by non-genomic and genomic actions.\nGenomic actions are mediated by the binding of T(3) receptors (TRs) to the thyroid response elements in the SERCA promotor and result in increased gene expression. \nThyroid hormone increases the transcript... | [] | [
"Furthermore, using specific inhibitors of the TH-activated kinases, we show that the long-term effects of TH on the expression of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA), alpha- and beta-myosin heavy chain (MHC) and cell growth are reverted, implying that what is initiated as a non-genomic action of the hormo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11145561",
"http://www.ncbi.nlm.nih.gov/pubmed/22975595",
"http://www.ncbi.nlm.nih.gov/pubmed/15242794",
"http://www.ncbi.nlm.nih.gov/pubmed/18658259",
"http://www.ncbi.nlm.nih.gov/pubmed/10198194",
"http://www.ncbi.nlm.nih.gov/pubmed/11470472",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0015349",
"http://www.uniprot.org/uniprot/THB_SHEEP",
"http://www.uniprot.org/uniprot/THA_MOUSE",
"http://www.uniprot.org/uniprot/THA_PYGAD",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013963",
"http://w... |
56d138fe3975bb303a000015 | factoid | Which trancription factor activates the betalain pathway? | [
"The beet Y locus encodes an anthocyanin MYB-like protein that activates the betalain red pigment pathway."
] | [
"The beet Y locus encodes an anthocyanin MYB-like protein that activates the betalain red pigment pathway."
] | [
"The beet Y locus encodes an anthocyanin MYB-like protein that activates the betalain red pigment pathway.",
"Some putative MYB, bHLH, and environmental stress-responsive transcription factor binding sites were detected in the PaDOD1 and PaDOD2 promoter regions."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/25436858",
"http://www.ncbi.nlm.nih.gov/pubmed/19791510"
] | [] | [] |
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