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medium_convergence_00308 | TRAF5 and TRAF6 both interact with a specific shared protein partner. Experimental deletion analysis indicates that TRAF2, this shared partner, and another TRAF family member interact with the C-terminal 85-amino acid tail of a receptor, with binding affinities ordered as TRAF2 > the shared partner > the other TRAF mem... | Tumor necrosis factor receptor superfamily member 11A | Medium | convergence | {"qa_id":"medium_convergence_00308","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF5 and TRAF6 both interact with a specific shared protein partner. Experimental deletion analysis indicates that TRAF2, this shared partner, and another T... | |
medium_convergence_00309 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. In a study of cytotoxic T-lymphocytes (GSE106475), this gene showed a log2 fold change of 1.132 and an adjusted p-value of 0.04244. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00309","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. In a study of cytotoxic T-lymphocytes (GSE106475), this gene showed a log2 fold change of 1.1... | |
medium_convergence_00310 | Both Human alphaherpesvirus 1 and Influenza A virus have been shown to downregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene exhibits a log2 fold change of -1.214 and an adjusted p-value of 0.00401. In which cellular component is the protein ... | cytosol | Medium | convergence | {"qa_id":"medium_convergence_00310","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Influenza A virus have been shown to downregulate a specific host gene. Experimental data from a monocytic leukemia cell li... | |
medium_convergence_00312 | Natalizumab and Mitomycin each share an interaction with a specific drug. Clinical evidence for one such shared drug describes a regimen involving continuous infusion of the drug (0.20 mg/kg per day) combined with leucovorin (7.5 mg/m2/day) and dexamethasone (20 mg on days 1 to 14), along with a bolus of Mitomycin C (1... | liver cancer | Medium | convergence | {"qa_id":"medium_convergence_00312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Natalizumab and Mitomycin each share an interaction with a specific drug. Clinical evidence for one such shared drug describes a regimen involving continuous... | |
medium_convergence_00314 | WNT2 and WNT5A are both involved in a shared biological process. Evidence indicates that several Wnts, including WNT2 and WNT5A, are expressed in the lens (specifically in the anterior epithelium and differentiating lens fiber cells). Which biological process, connected to this shared entity via a 'part of' relationshi... | camera-type eye development | Medium | convergence | {"qa_id":"medium_convergence_00314","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT2 and WNT5A are both involved in a shared biological process. Evidence indicates that several Wnts, including WNT2 and WNT5A, are expressed in the lens (s... | |
medium_convergence_00315 | Morphine and Ethanol share a common interacting drug. Evidence suggests that this shared drug, along with Ondansetron and pentazocine, may be useful for treating established pruritus. Which disease is this shared drug indicated for? | motion sickness | Medium | convergence | {"qa_id":"medium_convergence_00315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Ethanol share a common interacting drug. Evidence suggests that this shared drug, along with Ondansetron and pentazocine, may be useful for trea... | |
medium_convergence_00316 | Both Human immunodeficiency virus 1 and Orthohepevirus A downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of approximately -1.17 and an adjusted p-value of 0.0042. Which disease is associated with this gene? | Siddiqi syndrome | Medium | convergence | {"qa_id":"medium_convergence_00316","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Orthohepevirus A downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) ... | |
medium_convergence_00317 | FBXO45 and TP53 both interact with a specific shared protein. Evidence indicates that this shared entity is the human ortholog of FSN-1 and binds specifically to a p53 family member, triggering its proteasome-dependent degradation. Which protein product is encoded by this shared entity? | Tumor protein p73 | Medium | convergence | {"qa_id":"medium_convergence_00317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXO45 and TP53 both interact with a specific shared protein. Evidence indicates that this shared entity is the human ortholog of FSN-1 and binds specificall... | |
medium_convergence_00318 | CREBBP and CTNNB1 share multiple binding partners. One of these shared partners was identified because it binds to CBP. Which protein is encoded by the gene corresponding to this shared partner? | Chromatin remodeling protein SRCAP | Medium | convergence | {"qa_id":"medium_convergence_00318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and CTNNB1 share multiple binding partners. One of these shared partners was identified because it binds to CBP. Which protein is encoded by the gene ... | |
medium_convergence_00320 | CSNK2A1 and FBXW11 both interact with a shared protein. Experimental evidence indicates that this shared protein (hnRNP A2) associates with both catalytic and regulatory CK2 subunits, and that this interaction is independent of the presence of RNA. Which protein is encoded by the gene corresponding to this shared entit... | Heterogeneous nuclear ribonucleoproteins A2/B1 | Medium | convergence | {"qa_id":"medium_convergence_00320","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and FBXW11 both interact with a shared protein. Experimental evidence indicates that this shared protein (hnRNP A2) associates with both catalytic an... | |
medium_convergence_00321 | RHOB and TP53 share a common interacting partner. Evidence indicates that this shared partner forms a tricomplex with p53 and the E3 ubiquitin ligase HDM2 (also known as MDM2), thereby preventing the ubiquitination and degradation of p53. Which protein is encoded by the gene corresponding to this shared interacting par... | Protein numb homolog | Medium | convergence | {"qa_id":"medium_convergence_00321","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOB and TP53 share a common interacting partner. Evidence indicates that this shared partner forms a tricomplex with p53 and the E3 ubiquitin ligase HDM2 (a... | |
medium_convergence_00322 | SMC1A and SMC3 each share a binding partner. Evidence concerning one such shared partner indicates that it interacts with the structural maintenance of chromosomes proteins SMC1 and SMC3, which are reported to be subunits of the mitotic cohesin complex. Which protein is encoded by that shared partner? | Cohesin subunit SA-3 | Medium | convergence | {"qa_id":"medium_convergence_00322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMC1A and SMC3 each share a binding partner. Evidence concerning one such shared partner indicates that it interacts with the structural maintenance of chrom... | |
medium_convergence_00323 | STX12 and STX1A each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Both in vitro and in vivo binding studies showed that endobrevin binds to syntaxin 1.' Which protein is encoded by the gene corresponding to that shared entity? | Vesicle-associated membrane protein 8 | Medium | convergence | {"qa_id":"medium_convergence_00323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX12 and STX1A each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Both in vitro and in vivo binding ... | |
medium_convergence_00324 | EGFR and ATM share multiple interacting partners. One such shared partner is described in evidence stating: 'Simultaneously, this protein physically interacted with and enhanced the stability of EGFR via the K63-linked polyubiquitination in reverse.' Which protein is encoded by this specific shared partner? | E3 ubiquitin-protein ligase pellino homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_00324","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ATM share multiple interacting partners. One such shared partner is described in evidence stating: 'Simultaneously, this protein physically interact... | |
medium_convergence_00325 | ACTR1A and COPB1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Affinity chromatography experiments demonstrate that the shared partner binds directly to the Arp1 subunit of dynactin.' Which disease is associated with that specific shared partner via a... | neuralgia | Medium | convergence | {"qa_id":"medium_convergence_00325","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and COPB1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Affinity chromatography e... | |
medium_convergence_00326 | Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from a retinal pigment epithelium cell line (study GSE100839) indicates that for one such shared target, the log2 fold change is -1.417 and the adjusted p-value is 0.003956. Which disease is associated with this specific ... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from a retinal pigment epithelium cell line (study GSE1008... | |
medium_convergence_00327 | COPA and ARF4 both interact with a shared protein. Evidence regarding this shared entity states: 'Here we report the ubiquitous expression of two novel isotypes of coatomer subunits gamma- and zeta-COP that are incorporated into coatomer, and show that three isotypes exist of the complex defined by the subunit combinat... | Coatomer subunit gamma-2 | Medium | convergence | {"qa_id":"medium_convergence_00327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPA and ARF4 both interact with a shared protein. Evidence regarding this shared entity states: 'Here we report the ubiquitous expression of two novel isoty... | |
medium_convergence_00328 | SFRP1 and TP53 are both involved in more than one shared biological process. Evidence concerning one of these shared processes notes that SFRP-1 reduced the number of multipotent progenitors in in vitro culture of CD34(-)KSL cells, whereas SFRP-2 did not. Which cell type is the result of the acquisition of features ass... | hematopoietic stem cell | Medium | convergence | {"qa_id":"medium_convergence_00328","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SFRP1 and TP53 are both involved in more than one shared biological process. Evidence concerning one of these shared processes notes that SFRP-1 reduced the ... | |
medium_convergence_00329 | MYC and PA2G4 share multiple interacting partners. One such shared partner is associated with evidence that a protein encoded by this partner binds Ebp1 and suppresses its repressive effect on E2F-1. Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase BRE1A | Medium | convergence | {"qa_id":"medium_convergence_00329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PA2G4 share multiple interacting partners. One such shared partner is associated with evidence that a protein encoded by this partner binds Ebp1 and ... | |
medium_convergence_00330 | CTTN and RB1 share common interacting partners. One such partner is described in a study stating: 'In this study, we identified cortactin (CTTN), an actin-binding protein involved in the regulation of cytoskeleton dynamics and a potential prognostic marker for cancers, as a new cellular interacting partner of [the shar... | Ubiquitin carboxyl-terminal hydrolase 4 | Medium | convergence | {"qa_id":"medium_convergence_00330","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTTN and RB1 share common interacting partners. One such partner is described in a study stating: 'In this study, we identified cortactin (CTTN), an actin-bi... | |
medium_convergence_00331 | KRT18 and VIM both interact with a specific shared protein. Experimental evidence indicates that this shared protein interacts significantly with K16 and K18, and to some extent with K5, K6a, K8, and K14, as determined by two-hybrid methods. Which protein is encoded by the gene corresponding to this shared entity? | Trichoplein keratin filament-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT18 and VIM both interact with a specific shared protein. Experimental evidence indicates that this shared protein interacts significantly with K16 and K18... | |
medium_convergence_00332 | CTNNB1 and HIST1H4A share common binding partners. One such shared partner is implicated in evidence stating: 'The solution NMR structure of a protein complex with a H4K16ac peptide along with binding and mutational analyses reveal unique mechanistic features underlying recognition of H4K16ac.' Which protein encodes th... | Histone-lysine N-methyltransferase 2D | Medium | convergence | {"qa_id":"medium_convergence_00332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and HIST1H4A share common binding partners. One such shared partner is implicated in evidence stating: 'The solution NMR structure of a protein comple... | |
medium_convergence_00333 | KRAS and RHOC both interact with a specific gene product. Evidence regarding this shared entity states: 'In contrast, substrates of this gene product, such as KRas, Rac1, and RhoA, bind to it in both active and inactive forms which requires the presence of poly-basic residues in the C-termini of the GTPases.' Which cel... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_00333","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and RHOC both interact with a specific gene product. Evidence regarding this shared entity states: 'In contrast, substrates of this gene product, such a... | |
medium_convergence_00334 | PARP1 and BRD4 both interact with a specific shared gene product. Experimental evidence indicates that PARP-1 binds directly to the N-terminal region of this entity, immediately adjacent to its zinc finger domain. Which cell type is this entity enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_00334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and BRD4 both interact with a specific shared gene product. Experimental evidence indicates that PARP-1 binds directly to the N-terminal region of this... | |
medium_convergence_00336 | Etanercept and Infliximab both interact with a specific drug. Evidence indicates that the combination of this drug and Infliximab is currently under study. Which disease is this drug indicated for? | autoimmune hepatitis | Medium | convergence | {"qa_id":"medium_convergence_00336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Etanercept and Infliximab both interact with a specific drug. Evidence indicates that the combination of this drug and Infliximab is currently under study. W... | |
medium_convergence_00337 | Lepirudin and Tenecteplase both interact with a specific drug entity. Evidence regarding this shared entity includes a case report titled 'Tenecteplase for ST-elevation myocardial infarction in a patient treated with drotrecogin alfa (activated) for severe sepsis'. Which disease is indicated for this shared drug entity... | purpura fulminans | Medium | convergence | {"qa_id":"medium_convergence_00337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Lepirudin and Tenecteplase both interact with a specific drug entity. Evidence regarding this shared entity includes a case report titled 'Tenecteplase for S... | |
medium_convergence_00338 | CDKN1A and CHEK1 both interact with a specific shared protein. Experimental evidence indicates that p21 was co-immunoprecipitated with Cul4A and this shared protein when expressed in cells. Which protein is encoded by the gene corresponding to this shared entity? | DNA damage-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00338","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and CHEK1 both interact with a specific shared protein. Experimental evidence indicates that p21 was co-immunoprecipitated with Cul4A and this shared ... | |
medium_convergence_00339 | DMD and LAMA1 share multiple binding partners. One such shared partner is implicated in an immunoprecipitation assay using in vitro translated proteins, which demonstrated that, similar to beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding region of dystrophin,... | CASK | Medium | convergence | {"qa_id":"medium_convergence_00339","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMD and LAMA1 share multiple binding partners. One such shared partner is implicated in an immunoprecipitation assay using in vitro translated proteins, whic... | |
medium_convergence_00340 | CHD3 and MTA2 share multiple protein interaction partners. One of these shared partners is described in the context of DNA repair mechanisms, where evidence indicates that its depletion, inactivation, or the ablation of its interaction with a specific transcriptional corepressor (also known as SUMO1-interacting protein... | Transcription intermediary factor 1-beta | Medium | convergence | {"qa_id":"medium_convergence_00340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and MTA2 share multiple protein interaction partners. One of these shared partners is described in the context of DNA repair mechanisms, where evidence ... | |
medium_convergence_00342 | ESR1 and STAT3 share multiple interacting partners. One such partner is identified by evidence stating: 'Here, we show that ER is directly methylated at lysine 302 (K302) by the [methyltransferase] methyltransferase.' Which protein encodes this specific methyltransferase? | Histone-lysine N-methyltransferase SETD7 | Medium | convergence | {"qa_id":"medium_convergence_00342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and STAT3 share multiple interacting partners. One such partner is identified by evidence stating: 'Here, we show that ER is directly methylated at lysi... | |
medium_convergence_00343 | Oxytocin and Morphine both interact with a specific drug. Evidence regarding this drug states: 'This elevation of NH hormone production could be blocked by previous administration of B or the DA receptor antagonists HP, CPZ or SP.' Which disease is this drug indicated for? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Oxytocin and Morphine both interact with a specific drug. Evidence regarding this drug states: 'This elevation of NH hormone production could be blocked by p... | |
medium_convergence_00344 | Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific shared gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of approximately 4.81 and an adjusted p-value of approximately 0.0206. W... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific shared gene. Experimental data for this gene... | |
medium_convergence_00345 | Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of approximately 1.054 and an adjusted p-value of 0.003685. Which protein is encoded by this gene? | Gamma-glutamylcyclotransferase | Medium | convergence | {"qa_id":"medium_convergence_00345","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), th... | |
medium_convergence_00346 | CDK2 and CDKN1A share multiple interacting partners. One such shared partner is distinguished by evidence stating that it, along with Mammalian CKS1, binds CDK1 and participates in the control of cell cycle progression. Which disease is associated with this specific shared partner via a biomarker relationship? | Malignant tumor of urinary bladder | Medium | convergence | {"qa_id":"medium_convergence_00346","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CDKN1A share multiple interacting partners. One such shared partner is distinguished by evidence stating that it, along with Mammalian CKS1, binds C... | |
medium_convergence_00347 | GRM2 and GRM3 both interact with a shared protein entity. Evidence from co-immunoprecipitation studies indicates that this entity is encoded by the gene NHERF2, as both mGluR2 and mGluR3 associate with it in a cellular context. Which protein is connected to the gene NHERF2 through the 'encodes' relationship? | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | Medium | convergence | {"qa_id":"medium_convergence_00347","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRM2 and GRM3 both interact with a shared protein entity. Evidence from co-immunoprecipitation studies indicates that this entity is encoded by the gene NHER... | |
medium_convergence_00348 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.036 and an adjusted p-value of 1.152e-... | P2Y purinoceptor 1 | Medium | convergence | {"qa_id":"medium_convergence_00348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experiment... | |
medium_convergence_00349 | DDB1 and ERCC3 each interact with more than one shared protein. Evidence concerning one of these shared proteins states that it and UV-DDB were demonstrated to interact physically, and both are polyubiquitylated by the recombinant UV-DDB-ubiquitin ligase complex. Which protein is connected to that entity through the 'e... | DNA repair protein complementing XP-C cells | Medium | convergence | {"qa_id":"medium_convergence_00349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and ERCC3 each interact with more than one shared protein. Evidence concerning one of these shared proteins states that it and UV-DDB were demonstrated ... | |
medium_convergence_00350 | AKT1 and SFN both interact with a shared protein. Evidence regarding this shared protein states: 'This represents phosphorylation by the serine/threonine kinase protein kinase B (PKB), since PKB constitutively associates with this protein, phosphorylates it on a consensus phosphorylation site, Ser159, in vitro and inhi... | GRB2-associated-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and SFN both interact with a shared protein. Evidence regarding this shared protein states: 'This represents phosphorylation by the serine/threonine kin... | |
medium_convergence_00351 | LAMTOR2 and LAMTOR3 both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 (MP1) as an interactin... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_00351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and LAMTOR3 both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identi... | |
medium_convergence_00352 | BUB1B and AURKB each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint complex (MCC) as it consists of hBUBR1, hBUB3, CDC20, and MAD2 checkpoint proteins in near equal stoichiometry.' Which protein is encoded by that entity? | Mitotic checkpoint protein BUB3 | Medium | convergence | {"qa_id":"medium_convergence_00352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB1B and AURKB each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint co... | |
medium_convergence_00354 | CAND1 and CUL3 each interact with multiple shared partners. One such partner, when co-expressed with Cullin3, decreases the abundance of WNK1, WNK3, and WNK4 in HEK293T cells and significantly increases WNK4 ubiquitination in both HEK293T cells and in vitro assays. Which biological process is this specific partner invo... | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | convergence | {"qa_id":"medium_convergence_00354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL3 each interact with multiple shared partners. One such partner, when co-expressed with Cullin3, decreases the abundance of WNK1, WNK3, and WNK4... | |
medium_convergence_00355 | PRKDC and RUVBL1 share a common interacting partner. Evidence regarding one such partner states: 'Quantitative immunoblotting showed that the abundance of this protein is low compared with the PIKKs, and it preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs.' Which disease is associated with this speci... | TELO2-related intellectual disability-neurodevelopmental disorder | Medium | convergence | {"qa_id":"medium_convergence_00355","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and RUVBL1 share a common interacting partner. Evidence regarding one such partner states: 'Quantitative immunoblotting showed that the abundance of th... | |
medium_convergence_00357 | PRKN and UBR5 share multiple interacting partners. One such shared partner is implicated in a mechanism where the recruitment of parkin is mediated through its binding to gamma-tubulin, which accumulates in the centrosome in response to misfolded proteins. Which protein is encoded by the gene corresponding to this shar... | Tubulin gamma-1 chain | Medium | convergence | {"qa_id":"medium_convergence_00357","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and UBR5 share multiple interacting partners. One such shared partner is implicated in a mechanism where the recruitment of parkin is mediated through i... | |
medium_convergence_00358 | Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately 5.95 and an adjusted p-value of 2.645e-08. Which protein is encoded by this gene? | Interferon alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_00358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a ... | |
medium_convergence_00359 | Primate erythroparvovirus 1 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in erythroid progenitor cells (study GSE103460) reports a log2 fold change of approximately 3.13 and an adjusted p-value of 0.03565. Which cellular component is this gene located in? | membrane | Medium | convergence | {"qa_id":"medium_convergence_00359","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in erythroid progenitor cells (study GSE103... | |
medium_convergence_00360 | AGER and APP are both involved in more than one shared biological process. Evidence indicates that in the brain, FPS-ZM1 binds exclusively to RAGE, inhibiting a specific process and suppressing the activation of a specific cell type and the neuroinflammatory response. Which cell type is the primary input for that speci... | microglial cell | Medium | convergence | {"qa_id":"medium_convergence_00360","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGER and APP are both involved in more than one shared biological process. Evidence indicates that in the brain, FPS-ZM1 binds exclusively to RAGE, inhibitin... | |
medium_convergence_00361 | Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene from study GSE131840 indicates a log2 fold change of approximately 3.32 and an adjusted p-value of approximately 0.0396. Which cellular component is this gene located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_00361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene from study GSE131840 indicates a... | |
medium_convergence_00362 | POLH and RPA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that a specific protein binds to replicative DNA polymerase POLD3 and PDIP1 under normal conditions but preferentially associates with TLS polymerase η (POLH) upon UV damage. Which protein is enc... | DNA-dependent metalloprotease SPRTN | Medium | convergence | {"qa_id":"medium_convergence_00362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLH and RPA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that a specific protein binds to... | |
medium_convergence_00363 | CTNNB1 and CAND1 share multiple protein interaction partners. One such shared partner is identified by evidence showing that CA IX coprecipitates with beta-catenin. Which protein encodes this specific shared interaction partner? | Carbonic anhydrase 9 | Medium | convergence | {"qa_id":"medium_convergence_00363","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and CAND1 share multiple protein interaction partners. One such shared partner is identified by evidence showing that CA IX coprecipitates with beta-c... | |
medium_convergence_00364 | GNAI2 and GNAQ each interact with more than one shared protein. Evidence concerning one shared entity reports that WDR36 co-immunoprecipitated with Gαq and promoted the interaction between TPβ and Gαq. Which disease is connected to that entity through a biomarker relationship? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00364","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI2 and GNAQ each interact with more than one shared protein. Evidence concerning one shared entity reports that WDR36 co-immunoprecipitated with Gαq and p... | |
medium_convergence_00365 | POLH and RFC3 share multiple binding partners. One such partner is described as binding to replicative DNA polymerase POLD3 and PDIP1 under normal conditions, but preferentially associating with TLS polymerase η (POLH) upon UV damage. Which disease is associated with this specific partner? | progeroid features-hepatocellular carcinoma predisposition syndrome | Medium | convergence | {"qa_id":"medium_convergence_00365","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLH and RFC3 share multiple binding partners. One such partner is described as binding to replicative DNA polymerase POLD3 and PDIP1 under normal conditions... | |
medium_convergence_00366 | EP300 and FOXO1 share multiple binding partners. One such partner is described as interacting with p300 in vivo and serving as a target for acetylation by p300. Which protein is encoded by this specific shared partner? | Nuclear transcription factor Y subunit beta | Medium | convergence | {"qa_id":"medium_convergence_00366","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOXO1 share multiple binding partners. One such partner is described as interacting with p300 in vivo and serving as a target for acetylation by p3... | |
medium_convergence_00367 | CAND1 and CUL4B each interact with more than one shared partner. Evidence concerning one shared entity reports: 'Additionally, we found that both CUL4A and CUL4B can form an E3 complex with DNA damage-binding protein 1 (DDB1) and DDB1-CUL4-associated factor 4.' Which biological process is connected to that entity throu... | cell population proliferation | Medium | convergence | {"qa_id":"medium_convergence_00367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL4B each interact with more than one shared partner. Evidence concerning one shared entity reports: 'Additionally, we found that both CUL4A and C... | |
medium_convergence_00368 | Both Human immunodeficiency virus 1 and Dengue virus upregulate a specific gene. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.05 and an adjusted p-value of 0.0002354. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus upregulate a specific gene. Evidence for this gene in macrophages (from study GSE108897) reports a log2 ... | |
medium_convergence_00369 | Both Human alphaherpesvirus 1 and Zika virus are recorded to upregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene exhibits a log2 fold change of approximately 4.10 and an adjusted p-value of 0.0045. What molecular function is enabled by this g... | DNA-binding transcription factor activity | Medium | convergence | {"qa_id":"medium_convergence_00369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zika virus are recorded to upregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GS... | |
medium_convergence_00370 | Both Vaccinia virus and Enterovirus A are known to downregulate the expression of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), one such shared target gene exhibited a log2 fold change of approximately -3.15 and an adjusted p-value of 0.016. What molecular function is enabled by this... | protein xylosyltransferase activity | Medium | convergence | {"qa_id":"medium_convergence_00370","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Enterovirus A are known to downregulate the expression of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE1... | |
medium_convergence_00371 | EIF3D and EIF3G each share a binding partner. Evidence concerning one of these shared partners reports that it interacts directly with eIF3c, eIF3g, and eIF3j via glutathione S-transferase pull-down assays. Which protein is connected to that shared partner through the 'encodes' relation? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_00371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3D and EIF3G each share a binding partner. Evidence concerning one of these shared partners reports that it interacts directly with eIF3c, eIF3g, and eIF3... | |
medium_convergence_00372 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fold change of approximately 1.55 and an adjusted p-value of 0.03875. Which protein is encoded by this gene? | Enhancer of filamentation 1 | Medium | convergence | {"qa_id":"medium_convergence_00372","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fol... | |
medium_convergence_00373 | MDM2 and PTEN share multiple interacting partners. One such shared partner is distinguished by the fact that its N-terminal region (or that of its paralog) binds to the central acidic domain of MDM2. Which protein is encoded by this specific shared partner? | Small ribosomal subunit protein eS27 | Medium | convergence | {"qa_id":"medium_convergence_00373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and PTEN share multiple interacting partners. One such shared partner is distinguished by the fact that its N-terminal region (or that of its paralog) b... | |
medium_convergence_00374 | HIF3A and CUL2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We demonstrate that the common oxygen-dependent degradation domain of hHIF-3 alpha 1-3 splice variants is targeted for ubiquitylation by the pVHL complex in vitro and in vivo.' Which protein is connected to t... | von Hippel-Lindau disease tumor suppressor | Medium | convergence | {"qa_id":"medium_convergence_00374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIF3A and CUL2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We demonstrate that the common oxygen-depende... | |
medium_convergence_00375 | JUN and CBFB both interact with a specific transcription factor. Experimental evidence indicates that in the absence of DNA, this factor, but not NFATc1, binds directly to cJun/cJun dimers, whereas it does not bind to cFos/cJun heterodimers. Which protein is encoded by this transcription factor? | Nuclear factor of activated T-cells, cytoplasmic 2 | Medium | convergence | {"qa_id":"medium_convergence_00375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JUN and CBFB both interact with a specific transcription factor. Experimental evidence indicates that in the absence of DNA, this factor, but not NFATc1, bin... | |
medium_convergence_00376 | DNMT3B and MXD1 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that like Mad1, the HBP1 transrepression domain binds through a helical structure to the hydrophobic cleft of mSin3A PAH2.' Which protein is encoded by this shared partner? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_00376","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3B and MXD1 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that like Mad1, the HBP1 transrepression domain... | |
medium_convergence_00377 | HDAC1 and AR both interact with a shared gene product. Experimental evidence indicates that this shared entity interacts with a nuclear receptor homolog (specifically noting a strong interaction between the entity and its inhibitory domains demonstrated via GST pull-down assays). Which gene does this shared entity bind... | PPARA | Medium | convergence | {"qa_id":"medium_convergence_00377","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and AR both interact with a shared gene product. Experimental evidence indicates that this shared entity interacts with a nuclear receptor homolog (spe... | |
medium_convergence_00378 | GNAI2 and GNAQ both interact with a shared protein target. Experimental evidence indicates that WDR36 co-immunoprecipitates with Gαq and promotes the interaction between TPβ and Gαq. Which protein is encoded by the gene corresponding to this shared target? | Thromboxane A2 receptor | Medium | convergence | {"qa_id":"medium_convergence_00378","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI2 and GNAQ both interact with a shared protein target. Experimental evidence indicates that WDR36 co-immunoprecipitates with Gαq and promotes the interac... | |
medium_convergence_00379 | Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) reports a log2 fold change of approximately -1.58 and an adjusted p-value of 0.041. Which disease is associated with this gene as a biomarker? | malaria | Medium | convergence | {"qa_id":"medium_convergence_00379","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE... | |
medium_convergence_00380 | CDK2 and CDC7 both interact with a specific shared protein substrate. Experimental evidence indicates that after reoxygenation, this specific entity undergoes significant phosphorylation and shows increased coimmunoprecipitation with CDC7. Which disease is associated with this entity through genomic alterations? | Meier-Gorlin syndrome | Medium | convergence | {"qa_id":"medium_convergence_00380","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CDC7 both interact with a specific shared protein substrate. Experimental evidence indicates that after reoxygenation, this specific entity undergoe... | |
medium_convergence_00381 | Both IKBKB and PRKN share interaction partners. One such shared partner is described in evidence stating: 'Not only endogenously, but ectopically expressed IKK α and IKK β physically interacted with rictor.' Which disease is associated with this specific shared partner via a biomarker relationship? | kwashiorkor | Medium | convergence | {"qa_id":"medium_convergence_00381","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and PRKN share interaction partners. One such shared partner is described in evidence stating: 'Not only endogenously, but ectopically expressed I... | |
medium_convergence_00382 | CBX5 and BRD4 share multiple interacting partners. One such shared partner is distinguished by the following evidence: 'Here we show that KAP-1, CAF-1 p150, and this protein carry a canonical amino acid motif, PxVxL, which binds directly to the CSD with high affinity.' Which disease is associated with this specific sha... | Cornelia de Lange syndrome 1 | Medium | convergence | {"qa_id":"medium_convergence_00382","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX5 and BRD4 share multiple interacting partners. One such shared partner is distinguished by the following evidence: 'Here we show that KAP-1, CAF-1 p150, ... | |
medium_convergence_00383 | ELAVL1 and EP300 both interact with a specific shared protein. Evidence regarding this shared protein states: 'In this report we show that ProT(alpha) interacts with p300 similarly to p53 and other known oncoproteins at the CH1 amino-terminal domain as well as at a second domain downstream of the bromodomain which incl... | Prothymosin alpha | Medium | convergence | {"qa_id":"medium_convergence_00383","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELAVL1 and EP300 both interact with a specific shared protein. Evidence regarding this shared protein states: 'In this report we show that ProT(alpha) intera... | |
medium_convergence_00384 | AZI2 and UBC share multiple interacting partners. One such shared partner is described in evidence stating that SINTBAD constitutively binds TBK1 and a related kinase, but not other related kinases. Which protein is encoded by this shared interacting partner? | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Medium | convergence | {"qa_id":"medium_convergence_00384","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AZI2 and UBC share multiple interacting partners. One such shared partner is described in evidence stating that SINTBAD constitutively binds TBK1 and a relat... | |
medium_convergence_00385 | ESR1 and SOX2 both interact with a common protein partner. Evidence regarding this partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), responsible for the interaction with this partner, the suppression of ER by this partner could be reversed, suggesting that this suppression is conferred by t... | Nuclear receptor subfamily 2 group C member 1 | Medium | convergence | {"qa_id":"medium_convergence_00385","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and SOX2 both interact with a common protein partner. Evidence regarding this partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-3... | |
medium_convergence_00386 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of approximately -1.78 and an adjusted p-value of approximately 0.0042. Which protein is encoded by this gene? | Ectoderm-neural cortex protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study... | |
medium_convergence_00387 | CHRNA3 and SLC5A7 share common binding partners. One such shared partner is implicated in a study reporting that P2X2 co-immunoprecipitated with the alpha3-beta2 (but not alpha4-beta2) nicotinic acetylcholine receptor complex in both HEK cells and rat hippocampal membranes, indicating a physical association. Which prot... | Neuronal acetylcholine receptor subunit beta-2 | Medium | convergence | {"qa_id":"medium_convergence_00387","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRNA3 and SLC5A7 share common binding partners. One such shared partner is implicated in a study reporting that P2X2 co-immunoprecipitated with the alpha3-b... | |
medium_convergence_00388 | NFIX and SMARCA4 share multiple interaction partners. One such shared partner is described in a study stating: 'In this study, we show that this protein interacts with the SWI/SNF chromatin-remodeling protein BRG1 to regulate E-cadherin independently of CtBP, its traditional co-repressor.' What protein product is encod... | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_00388","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFIX and SMARCA4 share multiple interaction partners. One such shared partner is described in a study stating: 'In this study, we show that this protein inte... | |
medium_convergence_00389 | ARRB2 and GNG12 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase pull-down assay showed that the carboxyl terminus (CT) and the third intracellular loop (I3L) of DOR are both capable of and either domain is sufficient for bindi... | common cold | Medium | convergence | {"qa_id":"medium_convergence_00389","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB2 and GNG12 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase... | |
medium_convergence_00390 | CYLD and AKT1 both interact with a shared gene product. Experimental evidence indicates that the PH domain of PKB/Akt associates with this entity in vitro using purified fusion proteins, and this interaction moderately activates the entity's enzymatic activity. Which disease is associated with this specific gene produc... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_00390","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and AKT1 both interact with a shared gene product. Experimental evidence indicates that the PH domain of PKB/Akt associates with this entity in vitro us... | |
medium_convergence_00391 | TRIM28 and CDC37 both interact with a specific shared protein. Experimental evidence indicates that the interaction between KAP-1 and this shared protein was verified by co-immunoprecipitation (Co-IP). Which protein product is encoded by this shared protein? | Probable ATP-dependent RNA helicase DDX5 | Medium | convergence | {"qa_id":"medium_convergence_00391","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CDC37 both interact with a specific shared protein. Experimental evidence indicates that the interaction between KAP-1 and this shared protein was... | |
medium_convergence_00392 | CHMP4B and CC2D1B both interact with a shared protein partner. Evidence indicates that this partner interacts with CHMP4b/Shax (an ESCRT-III component) and EAP20 (an ESCRT-II component), as observed by co-immunoprecipitation of epitope-tagged proteins expressed in HEK-293 cells. Which protein is encoded by the gene cor... | Charged multivesicular body protein 6 | Medium | convergence | {"qa_id":"medium_convergence_00392","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CC2D1B both interact with a shared protein partner. Evidence indicates that this partner interacts with CHMP4b/Shax (an ESCRT-III component) and E... | |
medium_convergence_00393 | FBXW11 and AGO2 both interact with a specific shared protein. Experimental evidence indicates that both beta-Trcp1 and beta-Trcp2 bind specifically to this protein, and that point mutations in the beta-Trcp WD-repeat region completely abolish this binding, indicating an E3-substrate-type interaction. Which protein is e... | Ubiquitin carboxyl-terminal hydrolase 47 | Medium | convergence | {"qa_id":"medium_convergence_00393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and AGO2 both interact with a specific shared protein. Experimental evidence indicates that both beta-Trcp1 and beta-Trcp2 bind specifically to this p... | |
medium_convergence_00394 | DNMT1 and KDM1A share a common interacting partner. Evidence indicates that this shared partner is a novel methyl-binding protein that binds to K142-methylated DNMT1 and recruits a novel CRL4 complex. Which protein is encoded by this shared interacting partner? | Lethal(3)malignant brain tumor-like protein 3 | Medium | convergence | {"qa_id":"medium_convergence_00394","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT1 and KDM1A share a common interacting partner. Evidence indicates that this shared partner is a novel methyl-binding protein that binds to K142-methylat... | |
medium_convergence_00395 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data from a study on non-small cell lung adenocarcinoma cell lines (GSE147507) indicates that for one such shared target, the log2 fold change is -1.015 and the adjusted p-value is... | idiopathic hypersomnia | Medium | convergence | {"qa_id":"medium_convergence_00395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data from a study... | |
medium_convergence_00396 | FGFR1 and RAB4A share a common interacting partner. Evidence for this partner states: 'This domain mediates the direct interaction with the GTP-bound form of Rab4, a small GTPase that has been implicated in recycling from early endosomes to the cell surface.' Which disease is associated with this shared interacting par... | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGFR1 and RAB4A share a common interacting partner. Evidence for this partner states: 'This domain mediates the direct interaction with the GTP-bound form of... | |
medium_convergence_00397 | NOC4L and BMS1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'In this study, we identified an [entity]-interacting domain in BMS1, which is conserved in zebrafish and humans.' Which cell type is enriched for that specific shared protein? | basophil | Medium | convergence | {"qa_id":"medium_convergence_00397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOC4L and BMS1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'In this study, we identified an [entity]-interac... | |
medium_convergence_00399 | Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene in study GSE131840 reports a log2 fold change of approximately 2.53 and an adjusted p-value of 0.0083. Which protein does this gene product interact with? | CSDE1 | Medium | convergence | {"qa_id":"medium_convergence_00399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene in study GSE1318... | |
medium_convergence_00400 | DIS3 and DCP1A share common binding partners. One such partner is characterized by evidence stating that mutation of its six C-terminal lysines suppresses decapping activity and impairs interaction with the mRNA decay factors DCP2, EDC4, and itself, but not EDC3, thereby remodeling P-body architecture. Which cell type ... | basophil | Medium | convergence | {"qa_id":"medium_convergence_00400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and DCP1A share common binding partners. One such partner is characterized by evidence stating that mutation of its six C-terminal lysines suppresses de... | |
medium_convergence_00401 | Both Human alphaherpesvirus 3 and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 2.425 and an adjusted p-value of approximately 0.0001773. Which biological process is this gene involved i... | negative regulation of apoptotic process | Medium | convergence | {"qa_id":"medium_convergence_00401","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (stud... | |
medium_convergence_00402 | DYRK1A and ESR1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Our analysis revealed that ERalpha formed a protein complex with Smad and the ubiquitin ligase Smurf, and enhanced Smad ubiquitination and subsequent degradation in an estrogen-dependent manner.' Which protein i... | SMAD family member 2 | Medium | convergence | {"qa_id":"medium_convergence_00402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYRK1A and ESR1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Our analysis revealed that ERalpha formed a prot... | |
medium_convergence_00403 | MCM3 and CDC6 both interact with a shared protein partner. Experimental evidence indicates that in vitro binding assays show this shared partner does not interact directly with Stat1, suggesting its presence in the group of Stat1TAD-interacting proteins is due to its association with MCM3. Which protein is encoded by t... | DNA replication licensing factor MCM5 | Medium | convergence | {"qa_id":"medium_convergence_00403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM3 and CDC6 both interact with a shared protein partner. Experimental evidence indicates that in vitro binding assays show this shared partner does not int... | |
medium_convergence_00404 | HSP90AA1 and IFIH1 each interact with more than one shared protein. Evidence concerning one shared entity reports that this protein contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. Which disease is conn... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and IFIH1 each interact with more than one shared protein. Evidence concerning one shared entity reports that this protein contained an N-terminal C... | |
medium_convergence_00405 | CDH18 and CDH1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Whereas in the normal cells beta-catenin is found in association with E-cadherin, p120 Cas is not.' Which protein is encoded by the gene corresponding to that entity? | Junction plakoglobin | Medium | convergence | {"qa_id":"medium_convergence_00405","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH18 and CDH1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Whereas in the normal cells beta-cate... | |
medium_convergence_00406 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.66 and an adjusted p-value of approximately 0.038. Which cellular component is this gene located in? | focal adhesion | Medium | convergence | {"qa_id":"medium_convergence_00406","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold chan... | |
medium_convergence_00407 | HSPA8 and PDPK1 both interact with a specific shared gene product. Experimental evidence indicates that the hydrophobic motifs of PKCzeta and PKCiota, as well as PRK1 and PRK2, interact with the kinase domain of PDK1. Which protein is encoded by this shared gene product? | Protein kinase C iota type | Medium | convergence | {"qa_id":"medium_convergence_00407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and PDPK1 both interact with a specific shared gene product. Experimental evidence indicates that the hydrophobic motifs of PKCzeta and PKCiota, as wel... | |
medium_convergence_00408 | Dengue virus and Enterovirus A both downregulate a specific gene. In a study using a hepatoma cell line (GSE110512), the downregulation of this gene by these viruses was associated with a log2 fold change of -1.850 and an adjusted p-value of 0.01571. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 9B | Medium | convergence | {"qa_id":"medium_convergence_00408","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. In a study using a hepatoma cell line (GSE110512), the downregulation of this gene by these... | |
medium_convergence_00409 | ITGB3 and PDGFB share a common binding partner. Evidence regarding this shared entity states: 'The alpha v beta 3 integrin is present on a variety of cell types and appears to act as a receptor for thrombospondin on endothelial and smooth muscle cells.' Which disease is therapeutically connected to this shared entity? | mammary neoplasms, animal | Medium | convergence | {"qa_id":"medium_convergence_00409","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITGB3 and PDGFB share a common binding partner. Evidence regarding this shared entity states: 'The alpha v beta 3 integrin is present on a variety of cell ty... | |
medium_convergence_00410 | CTNNB1 and TRIM27 share interaction partners. One such shared partner is identified in a study screening a human deubiquitinase library, where it was found to bind, deubiquitinate, and stabilize the β-catenin protein. Which protein is encoded by this specific shared partner? | Ubiquitin carboxyl-terminal hydrolase 2 | Medium | convergence | {"qa_id":"medium_convergence_00410","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and TRIM27 share interaction partners. One such shared partner is identified in a study screening a human deubiquitinase library, where it was found t... | |
medium_convergence_00411 | ATP6AP2 and ERP29 both interact with a common protein. Experimental evidence indicates that when this common protein and ATP6AP2 were co-expressed in beta cells, they were shown to directly interact, as assessed by co-immunoprecipitation. Which protein is encoded by the gene corresponding to this common interacting par... | Glucagon-like peptide 1 receptor | Medium | convergence | {"qa_id":"medium_convergence_00411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP6AP2 and ERP29 both interact with a common protein. Experimental evidence indicates that when this common protein and ATP6AP2 were co-expressed in beta ce... | |
medium_convergence_00412 | NPLOC4 and VCP both interact with a shared protein. Evidence indicates that the ubiquitin-like domain of this shared protein recruits p97, enabling the extraction of client transmembrane domains into the cytosol. Which biological process is this shared protein involved in? | ERAD pathway | Medium | convergence | {"qa_id":"medium_convergence_00412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NPLOC4 and VCP both interact with a shared protein. Evidence indicates that the ubiquitin-like domain of this shared protein recruits p97, enabling the extra... | |
medium_convergence_00413 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of -1.062 and an adjusted p-value of 0.01604. Which cell type is this gene enriched in? | classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_00413","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (fr... | |
medium_convergence_00414 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold change of approximately 1.15 and an adjusted p-value of approximately 0.027. Which cell type is this gene enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_00414","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold change of app... | |
medium_convergence_00415 | ACAD9 and NDUFA1 both interact with a shared protein. Evidence indicates that this shared protein interacts with complex I assembly factors, including Ecsit, and is specifically required for the assembly of complex I. Which disease is associated with this shared protein? | mitochondrial complex I deficiency, nuclear type 11 | Medium | convergence | {"qa_id":"medium_convergence_00415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACAD9 and NDUFA1 both interact with a shared protein. Evidence indicates that this shared protein interacts with complex I assembly factors, including Ecsit,... |
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