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medium_hidden_intermediate_00492 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to endocytic recycling via an involvement relationship. One of these genes exhibits a log2 fold change of -1.623 and an adjusted p-value of 0.00512 in a specific study. Which cell type is enriched for that specific... | memory B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to endocytic recyc... | |
medium_hidden_intermediate_00493 | Human immunodeficiency virus 1 downregulates a gene that participates in the transport of small molecules. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.291 and an adjusted p-value of 0.007501. Which protein is encoded by this specific gene? | Adenosylhomocysteinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the transport of small molecules. In a study of mac... | |
medium_hidden_intermediate_00494 | A gene is upregulated by Influenza A virus and enriched in eosinophils. Evidence for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of 1.392 and an adjusted p-value of 7.304e-10. Which disease is associated with this gene? | metastatic melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Influenza A virus and enriched in eosinophils. Evidence for this gene in a non-small cell lung aden... | |
medium_hidden_intermediate_00495 | Zika virus downregulates a specific gene that is associated with kidney cancer. Experimental data for this gene reports a log2 fold change of approximately -1.025 and an adjusted p-value of 0.03165. Which protein is encoded by this gene? | TIMELESS-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00495","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with kidney cancer. Experimental data for this gene reports a lo... | |
medium_hidden_intermediate_00498 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and enriched in classical monocytes. This gene exhibits a log2 fold change of approximately 1.92 and an adjusted p-value of 6.93e-07. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00498","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and e... | |
medium_hidden_intermediate_00499 | Zika virus downregulates a specific gene, which in turn interacts with KIAA0753. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.621 and an adjusted p-value of 0.04535. Which protein is encoded by this gene? | Centrosomal protein POC5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with KIAA0753. Experimental data for this gene in glioma s... | |
medium_hidden_intermediate_00502 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of amino acids and derivatives. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of -1.407 and an adjusted p-value of 0.04705. Which protein is encoded by this specific gene... | Thioredoxin domain-containing protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00502","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of amino acids and derivative... | |
medium_hidden_intermediate_00503 | Vaccinia virus upregulates a gene that interacts with C21orf33. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of approximately 1.70 and an adjusted p-value of 5.74e-11. Which biological process is this gene involved in? | error-free translesion synthesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00503","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that interacts with C21orf33. In a study of cervical adenocarcinoma cell lines (GSE11238),... | |
medium_hidden_intermediate_00504 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to autism spectrum disorder as biomarkers. One of these genes exhibits a log2 fold change of approximately 1.76 and an adjusted p-value of 0.022 in a specific study. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to autism spectrum disord... | |
medium_hidden_intermediate_00505 | Pegivirus C is associated with the downregulation of a gene that enables zinc ion transmembrane transporter activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -2.18 and an adjusted p-value of approximately 0.00034. Which protein is encoded... | Zinc transporter 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of a gene that enables zinc ion transmembrane transporter activity. In a s... | |
medium_hidden_intermediate_00506 | Two genes are upregulated by Vaccinia virus and are enriched in Mucosa-associated invariant T (MAIT) cells. One of these genes exhibits a log2 fold change of 2.329 and an adjusted p-value of 1.338e-08 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this specific gene? | Peptidyl-prolyl cis-trans isomerase FKBP11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00506","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are enriched in Mucosa-associated invariant T (MAIT) cells. One of these gen... | |
medium_hidden_intermediate_00507 | Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of steroids. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of 2.129 and an adjusted p-value of 4.382e-05. Which protein interacts with this specific gene product? | SLC37A3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of steroids. In a study of macrophages... | |
medium_hidden_intermediate_00508 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which in turn interacts with MAPK8. This gene exhibits a log2 fold change of -4.798 and an adjusted p-value of 0.02329. Which protein is encoded by this gene? | Transcription factor JunD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00508","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_00511 | Zika virus downregulates a specific gene that is associated with atherosclerosis. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.037 and an adjusted p-value of 0.01023. Which cellular component is this gene located in? | Golgi membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00511","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with atherosclerosis. In a study of glioma stem cells (GSE114907... | |
medium_hidden_intermediate_00512 | Hepacivirus C upregulates a gene that is involved in the positive regulation of canonical NF-kappaB signal transduction. Experimental data for this gene in hepatocytes (study GSE132606) reports a log2 fold change of approximately 1.455 and an adjusted p-value of 0.001852. Which protein is encoded by this gene? | Protein shisa-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the positive regulation of canonical NF-kappaB signal transduction. Exp... | |
medium_hidden_intermediate_00514 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to multiple sclerosis as biomarkers. One of these genes is associated with a log2 fold change of approximately 1.141 and an adjusted p-value of 0.003728 in monocytes. What molecular function is enabled by this specific ge... | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00514","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to multiple sclerosis as ... | |
medium_hidden_intermediate_00515 | Two genes are downregulated by Human immunodeficiency virus 1 and serve as biomarkers for gastric cancer. One of these genes exhibits a log2 fold change of -1.841 and an adjusted p-value of 0.0002013 in macrophages (study GSE108897). Which disease is associated with this specific gene? | pituitary gland adenoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and serve as biomarkers for gastric cancer. One of these genes... | |
medium_hidden_intermediate_00516 | Zika virus downregulates a gene that participates in N-glycan antennae elongation in the medial/trans-Golgi. Experimental data from glioma stem cells (study GSE114907) indicates that one such gene has a log2 fold change of approximately -1.99 and an adjusted p-value of approximately 0.0397. Which protein is encoded by ... | Alpha-mannosidase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in N-glycan antennae elongation in the medial/trans-Golgi. Experimental da... | |
medium_hidden_intermediate_00517 | Minoxidil (topical) and Diphenhydramine are linked via a shared interacting agent. Evidence regarding one such agent notes that 'Some differences in diphenhydramine pharmacokinetics are, however, apparent.' Which disease is indicated for that specific interacting agent? | anxiety | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Minoxidil (topical) and Diphenhydramine are linked via a shared interacting agent. Evidence regarding one such agent notes t... | |
medium_hidden_intermediate_00519 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and is associated with lung carcinoma. Experimental data for this gene reports a log2 fold change of -1.043 and an adjusted p-value of 0.0001433. Which protein is encoded by this gene? | Cytochrome c | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00519","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and is associated with lung car... | |
medium_hidden_intermediate_00522 | Natural killer T cells express a specific protein marker that is associated with prostate cancer. Research indicates that this protein, also known as visfatin, plays a contributory and multifunctional role in prostate cancer progression, particularly in obese populations. In which cell type is this protein enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Natural killer T cells express a specific protein marker that is associated with prostate cancer. Research indicates that th... | |
medium_hidden_intermediate_00523 | A gene serves as a marker for AXL+SIGLEC6+ dendritic cells and is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a mean expression of 226.97 TPM, a z-score of 1.99, and a fold enrichment of 9.27. Which disease is associated with this gene as a biomarker? | mesothelioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for AXL+SIGLEC6+ dendritic cells and is enriched in plasmacytoid dendritic cells. Evidence for thi... | |
medium_hidden_intermediate_00524 | Two genes are upregulated by Vaccinia virus and are enriched in Regulatory T (Treg) cells. One of these genes exhibits a log2 fold change of 1.761 and an adjusted p-value of 1.537e-10 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | oxoglutaricaciduria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00524","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are enriched in Regulatory T (Treg) cells. One of these genes exhibits a log... | |
medium_hidden_intermediate_00526 | Measles morbillivirus upregulates a gene that participates in the RAC1 GTPase cycle. Evidence for one such gene reports a log2 fold change of 2.426 and an adjusted p-value of 0.002282. Which cellular component is this gene located in? | protein-containing complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the RAC1 GTPase cycle. Evidence for one such gene reports a lo... | |
medium_hidden_intermediate_00528 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable phospholipid binding. One such gene exhibited a log2 fold change of 1.630 and an adjusted p-value of 7.087e-05. Which protein is encoded by this specific gene? | Tyrosine-protein kinase Tec | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00528","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_00530 | Two genes are structurally linked to Pegivirus C via downregulation and to WASF2 via binding. One of these genes exhibits a log2 fold change of -1.296 and an adjusted p-value of 0.0004135 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to WASF2 via binding. One of these genes exhibits a ... | |
medium_hidden_intermediate_00532 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycerophospholipid biosynthesis. Evidence for this gene reports a log2 fold change of 1.368 and an adjusted p-value of 0.04515. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00532","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycerophospholipid biosy... | |
medium_hidden_intermediate_00533 | Pegivirus C downregulates a gene that participates in the MyD88 dependent cascade initiated on endosome. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.617 and an adjusted p-value of 0.004731. Which protein is encoded by this specific gene? | NF-kappa-B inhibitor-interacting Ras-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00533","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in the MyD88 dependent cascade initiated on endosome. In a study of perip... | |
medium_hidden_intermediate_00534 | RABAC1 interacts with a specific protein that enables protein binding. Experimental evidence indicates that this protein, along with NDRG1-4, binds to PRA1 in vitro (confirmed by GST pull-down assay and immunoprecipitation) and colocalizes with it in HCT116 cells (verified by confocal microscopy). Which biological proc... | substantia nigra development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RABAC1 interacts with a specific protein that enables protein binding. Experimental evidence indicates that this protein, al... | |
medium_hidden_intermediate_00535 | PGAM5 interacts with a protein that is located in the cytoplasm. Evidence indicates that the N terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of this interacting protein. Which protein is encoded by the gene corresponding to this interactin... | Kelch-like ECH-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00535","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PGAM5 interacts with a protein that is located in the cytoplasm. Evidence indicates that the N terminus of the PGAM5 protein... | |
medium_hidden_intermediate_00536 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with ACTB. This gene exhibited a log2 fold change of approximately -1.043 and an adjusted p-value of 0.01449. Which protein is encoded by this gene? | F-box only protein 25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00536","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_00537 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate certain genes that participate in biological oxidations. One such gene exhibited a log2 fold change of approximately -1.26 and an adjusted p-value of 0.00062. Which protein is encoded by this specific gene? | Amine oxidase [flavin-containing] B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate certain genes that par... | |
medium_hidden_intermediate_00539 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Pre-NOTCH Transcription and Translation. Evidence for one such gene reports a log2 fold change of 1.186 and an adjusted p-value of 0.009529. Which cell type is that gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Pre-NOTCH Transcription and Tr... | |
medium_hidden_intermediate_00540 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the function of Chromatin modifying enzymes. Experimental data for this gene reports a log2 fold change of 3.126 and an adjusted p-value of 0.0004802. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase Jade-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00540","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the function of Chromatin... | |
medium_hidden_intermediate_00541 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in the negative regulation of protein ubiquitination. Evidence for this gene reports a log2 fold change of approximately 1.208 and an adjusted p-value of 0.000716. Which protein is encoded by this gene? | Influenza virus NS1A-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in the negative regul... | |
medium_hidden_intermediate_00544 | Two genes are downregulated by Measles morbillivirus and participate in lipid metabolism. One of these genes exhibits a log2 fold change of -1.240 and an adjusted p-value of 0.0008484. Which cellular component is the location of this specific gene? | endoplasmic reticulum membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Measles morbillivirus and participate in lipid metabolism. One of these genes exhibits a log2... | |
medium_hidden_intermediate_00545 | Vaccinia virus upregulates multiple genes that are located on the cell surface. One such gene exhibits a log2 fold change of approximately 1.47 and an adjusted p-value of 2.35e-07 in cervical adenocarcinoma cells. Which protein does this specific gene product bind to? | KLRB1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00545","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates multiple genes that are located on the cell surface. One such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_00546 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in PI Metabolism. Evidence for this gene reports a log2 fold change of -1.833 and an adjusted p-value of 0.01889. Which protein is encoded by this gene? | Pleckstrin homology domain-containing family A member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00546","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in PI Metabolism. Evidence for ... | |
medium_hidden_intermediate_00547 | In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpesvirus 8 and enabling DNA-binding transcription factor activity. This specific gene exhibits a log2 fold change of -1.723 and an adjusted p-value of 0.02851. Which biological process is this gene i... | central nervous system development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpes... | |
medium_hidden_intermediate_00548 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to Cytokine Signaling in Immune system via a participation relationship. One of these genes exhibits a log2 fold change of -1.256 and an adjusted p-value of 0.02217 in macrophages (study GSE108897). Which disease i... | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to Cytokine Signal... | |
medium_hidden_intermediate_00549 | Human betaherpesvirus 5 upregulates a gene that is enriched in memory B cells. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of 1.195 and an adjusted p-value of 0.03944. Which molecular function is enabled by this gene? | cAMP-dependent protein kinase inhibitor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00549","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is enriched in memory B cells. Evidence for this gene in foreskin fibroblast... | |
medium_hidden_intermediate_00551 | Zika virus downregulates a gene that enables protein heterodimerization activity. Experimental data for this gene in glioblastoma multiforme cancer stem cells (study GSE102924) show a log2 fold change of approximately -1.24 and an adjusted p-value of 0.0302. Which protein is encoded by this gene? | Potassium channel subfamily K member 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00551","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables protein heterodimerization activity. Experimental data for this gene in gliobla... | |
medium_hidden_intermediate_00552 | A gene is downregulated by Vaccinia virus and participates in chromatin modifying enzyme activity. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.740 and an adjusted p-value of 0.04642. Which disease is associated with this gene? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00552","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and participates in chromatin modifying enzyme activity. Experimental data for thi... | |
medium_hidden_intermediate_00555 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription. Experimental data for this gene shows a log2 fold change of approximately -1.23 and an adjusted p-value of approximately 0.0145. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription. E... | |
medium_hidden_intermediate_00556 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by the virus and its product is located in the endoplasmic reticulum. This gene exhibits a log2 fold change of -1.702 and an adjusted p-value of 0.008429. Which protein is encoded by this gene? | Glutathione peroxidase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by ... | |
medium_hidden_intermediate_00557 | Zika virus upregulates a specific gene that is enriched in classical monocytes. Transcriptomic data for this gene indicates a log2 fold change of approximately 5.975 and an adjusted p-value of 0.00902. In which cellular component is this gene located? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that is enriched in classical monocytes. Transcriptomic data for this gene indicates ... | |
medium_hidden_intermediate_00558 | Zika virus downregulates a specific gene that is involved in the negative regulation of programmed cell death. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.746 and an adjusted p-value of 0.009533. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the negative regulation of programmed cell death. In a study of... | |
medium_hidden_intermediate_00559 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with LAMP1. This gene exhibited a log2 fold change of approximately -1.596 and an adjusted p-value of 0.01531. Which protein is encoded by this gene? | UbiA prenyltransferase domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00559","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_00560 | Human immunodeficiency virus 1 downregulates a gene that participates in Developmental Biology. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -2.895 and an adjusted p-value of 0.02495. Which protein is encoded by this gene? | Signal transducer CD24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00560","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in Developmental Biology. In a study of macrophages (G... | |
medium_hidden_intermediate_00564 | Two genes are downregulated by Human immunodeficiency virus 1 and participate in the Innate Immune System. One of these genes exhibits a log2 fold change of -1.459 and an adjusted p-value of 0.02561 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00564","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and participate in the Innate Immune System. One of these gene... | |
medium_hidden_intermediate_00565 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable pyridoxal phosphate binding. One such gene exhibited a log2 fold change of 4.351 and an adjusted p-value of 5.472e-09. Which protein is encoded by this specific gene? | Pyridoxine-5'-phosphate oxidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_00566 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables small GTPase binding. Evidence for this gene reports a log2 fold change of 3.063 and an adjusted p-value of 3.367e-07. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00566","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables small GTPase binding. Evidence for thi... | |
medium_hidden_intermediate_00567 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to the regulation of heart rate via an 'involved in' relationship. One of these genes is associated with a log2 fold change of approximately 4.54 and an adjusted p-value of approximately 0.00... | Sarcoplasmic reticulum histidine-rich calcium-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00567","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_00568 | Zika virus downregulates a specific gene, which in turn interacts with RHOB. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.20 and an adjusted p-value of 0.002154. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RHOB. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_00569 | Two genes are upregulated by Enterovirus A and interact with CAND1. One of these genes exhibits a log2 fold change of 2.408 and an adjusted p-value of 0.003359 in rhabdomyosarcoma cells. Which disease is associated with genomic alterations in this specific gene? | malaria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and interact with CAND1. One of these genes exhibits a log2 fold change of 2.408 ... | |
medium_hidden_intermediate_00573 | Hepacivirus C is reported to downregulate a specific gene, which is in turn enriched in naive CD8+ T cells. Experimental data for this gene shows a log2 fold change of approximately -1.62 and an adjusted p-value of approximately 0.04. Which protein is encoded by this gene? | Matrix remodeling-associated protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00573","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is in turn enriched in naive CD8+ T cells. Experimental dat... | |
medium_hidden_intermediate_00574 | Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in non-classical monocytes. One such gene exhibits a log2 fold change of -1.042 and an adjusted p-value of 0.002373 in cytotoxic T-lymphocytes. Which biological process is this gene involved in? | extraction of mislocalized protein from ER membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in non-classical monocytes.... | |
medium_hidden_intermediate_00575 | Two genes are upregulated by Vaccinia virus and participate in aerobic respiration and respiratory electron transport. One of these genes shows a log2 fold change of 1.597 and an adjusted p-value of 2.142e-06 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in aerobic respiration and respiratory electron transport. One o... | |
medium_hidden_intermediate_00576 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Innate Immune System. One such gene exhibits a log2 fold change of approximately 3.92 and an adjusted p-value of approximately 0.0012. Which biological process is this specific gene involved in? | negative regulation of complement activation, lectin pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Innate Imm... | |
medium_hidden_intermediate_00578 | Cardiovirus A downregulates a gene that participates in the Adaptive Immune System. Evidence for one such gene reports a log2 fold change of -1.046 and an adjusted p-value of 0.01375. Which gene interacts with this specific entity? | SIAH1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that participates in the Adaptive Immune System. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_00579 | PSMB8 is involved in a biological process that is a subtype of T-helper cell differentiation. Evidence for one such process describes it as the process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell, characterized by a CD4-positive, alpha-beta T cell phenotype, T... | T-helper 1 type immune response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00579","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMB8 is involved in a biological process that is a subtype of T-helper cell differentiation. Evidence for one such process ... | |
medium_hidden_intermediate_00580 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the extracellular region. Transcriptomic data for this gene in lung cells shows a log2 fold change of -1.501 and an adjusted p-value of 0.01358. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00580","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the extracellular region.... | |
medium_hidden_intermediate_00581 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that participates in Membrane Trafficking. This gene exhibited a log2 fold change of approximately -1.135 and an adjusted p-value of 0.02809. Which biological process is this gene involved in? | mitotic cell cycle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00581","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that partici... | |
medium_hidden_intermediate_00583 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in double-strand break repair via homologous recombination. This specific gene exhibited a log2 fold change of 1.551 and an adjusted p-value of 0.005213. Which protein is encoded by this gene? | DNA repair protein SWI5 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in ... | |
medium_hidden_intermediate_00584 | Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are associated with asthma. One such gene exhibits a log2 fold change of 3.946 and an adjusted p-value of 7.753e-05 in bronchial epithelial cells. Which protein is encoded by this specific gene? | C-X-C motif chemokine 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00584","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are associated with asthma. One such g... | |
medium_hidden_intermediate_00585 | In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene is upregulated by the virus and its expression is enriched in eosinophils. Evidence for this gene reports a log2 fold change of approximately 1.15 and an adjusted p-value of 0.0085. Which protein is encoded by t... | Ankyrin repeat and BTB/POZ domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00585","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene is upregulated ... | |
medium_hidden_intermediate_00586 | Vaccinia virus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for this gene reports a log2 fold change of 2.549 and an adjusted p-value of 2.422e-06. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00586","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidenc... | |
medium_hidden_intermediate_00588 | Two genes are identified as markers of germ cells and both enable RNA polymerase II transcription regulatory region sequence-specific DNA binding. One of these genes represses gene transcription through direct DNA binding to the promoter region of target genes by recruiting the transcriptional co-regulator TCERG1. Whic... | oropharynx cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers of germ cells and both enable RNA polymerase II transcription regulatory region sequence... | |
medium_hidden_intermediate_00590 | Zika virus upregulates a specific gene that is located in the endoplasmic reticulum. Transcriptomic data for this gene in neural stem cells shows a log2 fold change of approximately 1.63 and an adjusted p-value of 0.0158. Which disease is associated with this gene as a biomarker? | Epstein-Barr virus infection | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00590","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that is located in the endoplasmic reticulum. Transcriptomic data for this gene in ne... | |
medium_hidden_intermediate_00591 | Oral epithelium is a subtype of two distinct anatomical entities, both of which are subtypes of epithelium. One of these entities is described as an epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non-keratinized, serving as the primary barrier ... | mucosa | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00591","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Oral epithelium is a subtype of two distinct anatomical entities, both of which are subtypes of epithelium. One of these ent... | |
medium_hidden_intermediate_00592 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn participates in cellular responses to stimuli. This gene exhibited a log2 fold change of approximately -1.10 and an adjusted p-value of 0.0016. Which protei... | Biliverdin reductase A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00592","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_00593 | Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in Gamma delta (γδ) T cells. One such gene exhibits a log2 fold change of approximately -1.21 and an adjusted p-value of 0.01006. Which protein is encoded by this gene? | Golgi membrane protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00593","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in Gamma delta (γδ) T cells... | |
medium_hidden_intermediate_00594 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BTRC. One of these genes exhibits a log2 fold change of 1.725 and an adjusted p-value of 0.0005067 in bronchial epithelial cells. Which disease is associated with this specific gene? | anencephaly 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BTRC. One of these gene... | |
medium_hidden_intermediate_00596 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene was found to be upregulated and involved in protein dephosphorylation. This gene exhibited a log2 fold change of approximately 1.49 and an adjusted p-value of approximately 2.31e-05. Which protein is encoded by this ... | Receptor-type tyrosine-protein phosphatase H | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00596","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene was found to be upre... | |
medium_hidden_intermediate_00597 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to upregulate a gene that enables protein homodimerization activity. This specific gene exhibited a log2 fold change of 1.825 and an adjusted p-value of 0.003947. Which protein is encoded by this gene? | Heat shock protein beta-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to upregulate a gene that enables protein ho... | |
medium_hidden_intermediate_00603 | Cardiovirus A downregulates a gene that is involved in the defense response to virus. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that this gene has a log2 fold change of approximately -1.05 and an adjusted p-value of approximately 0.036. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM52 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00603","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is involved in the defense response to virus. Experimental data from a cervical aden... | |
medium_hidden_intermediate_00604 | Zika virus infection leads to the downregulation of specific genes that encode proteins with 2-oxoglutarate-dependent dioxygenase activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -3.617 and an adjusted p-value of 0.005349. Which protein is encoded by this specific gen... | 2-oxoglutarate and iron-dependent oxygenase JMJD4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of specific genes that encode proteins with 2-oxoglutarate-dependent dioxyg... | |
medium_hidden_intermediate_00605 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables unfolded protein binding. This specific gene exhibited a log2 fold change of -1.629 and an adjusted p-value of 0.01007. Which protein is encoded by this gene? | 10 kDa heat shock protein, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00605","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables unfolded... | |
medium_hidden_intermediate_00608 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with LZTS2. One of these genes was reported in a study on colonic adenocarcinoma cell lines (GSE148729) with a log2 fold change of -1.571 and an adjusted p-value of 0.04718. Which protein is encoded by this specific gene? | IQ domain-containing protein N | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with LZTS2. One of these g... | |
medium_hidden_intermediate_00609 | Enterovirus A infection is associated with the upregulation of specific genes, which are subsequently found to be enriched in naive CD8+ T cells. One such gene exhibits a log2 fold change of approximately 3.05 and an adjusted p-value of 0.0259 in rhabdomyosarcoma cells. Which protein is encoded by this gene? | Microtubule-associated tumor suppressor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A infection is associated with the upregulation of specific genes, which are subsequently found to be enriched i... | |
medium_hidden_intermediate_00610 | EP300 interacts with a protein that enables transcription cis-regulatory region binding. Evidence indicates that this protein, identified as the ets DNA-binding subunit of GABP, physically interacts with p300 in myeloid cells. Which protein is encoded by this gene? | GA-binding protein alpha chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EP300 interacts with a protein that enables transcription cis-regulatory region binding. Evidence indicates that this protei... | |
medium_hidden_intermediate_00611 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables UDP-galactosyltransferase activity. Experimental data for this gene reports a log2 fold change of -1.025 and an adjusted p-value of 0.03944. Which protein is encoded by this gene? | Beta-1,3-galactosyltransferase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables UDP-galactosyltransferase activ... | |
medium_hidden_intermediate_00612 | Two genes are upregulated by Vaccinia virus and participate in the RHO GTPase cycle. One of these genes shows a log2 fold change of 2.288 and an adjusted p-value of 9.614e-07 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | pancreatic endocrine carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00612","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in the RHO GTPase cycle. One of these genes shows a log2 fold ch... | |
medium_hidden_intermediate_00614 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the synthesis of 15-eicosatetraenoic acid derivatives via a participation relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1... | Polyunsaturated fatty acid lipoxygenase ALOX15B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00614","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_00615 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a specific gene that enables zinc ion binding. This gene exhibited a log2 fold change of -1.033 and an adjusted p-value of 0.003629. Which protein is encoded by this gene? | Pappalysin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00615","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_00616 | In a study of macrophages (GSE108897), two genes are downregulated by Human immunodeficiency virus 1 and both enable alpha-tubulin binding. One of these genes exhibits a log2 fold change of approximately -1.152 and an adjusted p-value of 0.004027. Which biological process is the gene matching these statistical values i... | chromosome segregation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00616","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), two genes are downregulated by Human immunodeficiency virus 1 and both enable alpha-t... | |
medium_hidden_intermediate_00617 | Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with TFDP1. Experimental data for this gene shows a log2 fold change of -1.636 and an adjusted p-value of 0.02928. Which protein is encoded by this gene? | COMM domain-containing protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with TFDP1. Experimental data for this ge... | |
medium_hidden_intermediate_00619 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a gene that enables sequence-specific DNA binding. One such gene exhibits a log2 fold change of -1.719 and an adjusted p-value of 0.02403. Which protein is encoded by this specific gene? | ETS-related transcription factor Elf-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00619","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a gene that ... | |
medium_hidden_intermediate_00620 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes, which in turn interact with the ELOC protein complex component TCEB1. One such upregulated gene exhibits a log2 fold change of approximately 1.65 and an adjusted p-value of 1.91e-07. Which protei... | Leucine-rich repeat-containing protein 58 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00620","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes,... | |
medium_hidden_intermediate_00621 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn participates in cellular responses to stimuli. In a study using foreskin fibroblast cell lines (GSE111036), this gene exhibited a log2 fold change of -1.796 and an adjusted p-value of 0.04313. Which protein is encoded by this gene? | Guanine nucleotide-exchange factor SEC12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn participates in cellular responses to sti... | |
medium_hidden_intermediate_00622 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which is subsequently enriched in Regulatory T (Treg) cells. This gene exhibited a log2 fold change of 8.833 and an adjusted p-value of 0.0001119. Which protein is encoded by this gene? | T-cell immunoglobulin and mucin domain-containing protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00622","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_00623 | A gene is upregulated by Human gammaherpesvirus 8 and its protein product is located in the membrane. Transcriptomic data for this gene in a non-Hodgkin lymphoma cell line shows a log2 fold change of approximately 1.01 and an adjusted p-value of 0.031. Which gene interacts with this identified gene? | TK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00623","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and its protein product is located in the membrane. Transcriptomic data fo... | |
medium_hidden_intermediate_00624 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and subsequently linked to breast cancer via genomic alterations. One such gene exhibits a log2 fold change of -1.055 and an adjusted p-value of 0.003131. Which protein is encoded by this specific gene? | Phosphatidylethanolamine N-methyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00624","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and subsequen... | |
medium_hidden_intermediate_00625 | In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and participates in Signaling by Rho GTPases. Evidence for this gene reports a log2 fold change of approximately -1.036 and an adjusted p-value of 0.01125. Which protein is encoded by this gene? | Rho guanine nucleotide exchange factor 17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00625","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and particip... | |
medium_hidden_intermediate_00626 | Human alphaherpesvirus 1 upregulates a specific gene product that participates in the CHD6, CHD7, CHD8, CHD9 subfamily. In a study of monocytic leukemia cell lines (GSE114966), this gene product showed a log2 fold change of approximately 2.92 and an adjusted p-value of approximately 0.0097. Which protein is encoded by ... | Histone H4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene product that participates in the CHD6, CHD7, CHD8, CHD9 subfamily. In a... | |
medium_hidden_intermediate_00627 | Two genes are downregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold change of approximately -1.04 and an adjusted p-value of 0.0012 in cervical adenocarcinoma cell lines. Which disease is linked to this specific gene via a biomarker relationship? | microcephaly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00627","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold c... | |
medium_hidden_intermediate_00629 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn interacts with ASF1B. This gene exhibits a log2 fold change of approximately 1.369 and an adjusted p-value of 0.002767. Which protein is encoded by this upregulated gene? | Protein MMS22-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00629","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_00630 | Zika virus downregulates a gene that enables ubiquitin-protein transferase activity. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -2.848 and an adjusted p-value of 0.005958. Which cell type is this specific gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00630","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables ubiquitin-protein transferase activity. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_00632 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to SH3KBP1 via a binding relationship. One of these genes is reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 1.167 and an adjusted p-value of 0... | immunodeficiency 76 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00632","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_00633 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulated and involved in the regulation of the epidermal growth factor receptor signaling pathway. Evidence for this gene shows a log2 fold change of approximately -1.500 and an adjusted p-value of 0.00... | Inactive rhomboid protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00633","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulat... |
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