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medium_hidden_intermediate_00781 | Human betaherpesvirus 5 is reported to upregulate a gene that is involved in chemical synaptic transmission. In a study using foreskin fibroblast cell lines, this gene exhibited a log2 fold change of 2.359 and an adjusted p-value of 0.04605. Which protein is encoded by this gene? | Neuronal pentraxin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00781","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is involved in chemical synaptic transmission. In a study usin... | |
medium_hidden_intermediate_00783 | Two genes are downregulated by Pegivirus C and are associated with anxiety. One of these genes exhibits a log2 fold change of -1.218 and an adjusted p-value of 0.003455 in peripheral blood mononuclear cells (study GSE131504). Which disease is linked to this specific gene through genomic alterations? | Takayasu arteritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00783","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are associated with anxiety. One of these genes exhibits a log2 fold change o... | |
medium_hidden_intermediate_00784 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are upregulated and enable protein-macromolecule adaptor activity. One of these genes exhibits a log2 fold change of 3.346 and an adjusted p-value of 0.001916. Which protein is encoded by the gene matchin... | E3 ubiquitin-protein ligase TRIM22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are upre... | |
medium_hidden_intermediate_00785 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with NPM1. Evidence for one such gene reports a log2 fold change of 2.072 and an adjusted p-value of 0.02627. Which protein is encoded by that gene? | Growth arrest and DNA damage-inducible protein GADD45 alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00785","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with NPM1. Evidence for one such gen... | |
medium_hidden_intermediate_00786 | Zika virus downregulates a specific gene, which in turn interacts with SRPK2. Experimental data for this intermediate gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.097 and an adjusted p-value of 0.0079. Which biological process is this intermediate gene involved in? | regulation of RNA splicing | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with SRPK2. Experimental data for this intermediate gene i... | |
medium_hidden_intermediate_00788 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to 'negative regulation of cell population proliferation' via an 'involved in' relationship. One of these genes is associated with experimental evidence showing a log2 fold change of approxi... | APOA1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_00789 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that binds to SMDT1. One such gene exhibits a log2 fold change of 1.596 and an adjusted p-value of 0.00738. Which protein is encoded by this gene? | Calcium uniporter protein, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00789","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that binds to SMDT1. One such gene exhibits a log2 ... | |
medium_hidden_intermediate_00791 | Zika virus downregulates a specific gene that participates in developmental biology. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.631 and an adjusted p-value of 0.01919. Which biological process is this gene involved in? | nervous system development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in developmental biology. Experimental data for this gene in glio... | |
medium_hidden_intermediate_00792 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable the structural constituent of cytoskeleton function. One such gene exhibited a log2 fold change of approximately 6.88 and an adjusted p-value of approximately 1.93e-06. Which protein ... | Phakinin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_00793 | Two genes are structurally positioned between Pegivirus C and HIST1H4A, linked by downregulation from the virus and interaction with the histone. One of these genes exhibits a log2 fold change of approximately -1.14 and an adjusted p-value of 0.001275 in peripheral blood mononuclear cells. Which disease is associated w... | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally positioned between Pegivirus C and HIST1H4A, linked by downregulation from the virus and interact... | |
medium_hidden_intermediate_00794 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with YEATS4. Evidence for one such gene reports a log2 fold change of -2.426 and an adjusted p-value of 0.03163. Which protein is encoded by that gene? | Protein c-Fos | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00794","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with YEATS4. Evidence for one such... | |
medium_hidden_intermediate_00795 | Zika virus downregulates a gene that participates in tRNA processing. Experimental data from glioma stem cells (study GSE114907) indicates that one such gene has a log2 fold change of -3.508 and an adjusted p-value of 0.007014. Which protein interacts with this specific gene product? | TPD52L2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in tRNA processing. Experimental data from glioma stem cells (study GSE114... | |
medium_hidden_intermediate_00796 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in the Cell Cycle. This gene exhibited a log2 fold change of approximately 2.66 and an adjusted p-value of 2.743e-07. Which biological process is this gene involved in? | DNA replication | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00796","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_00798 | Measles morbillivirus upregulates a gene that enables ubiquitin-like ligase-substrate adaptor activity. In study GSE131840, one such gene exhibits a log2 fold change of 1.091 and an adjusted p-value of 0.01279. Which protein is encoded by this specific gene? | Kelch domain-containing protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00798","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables ubiquitin-like ligase-substrate adaptor activity. In study GSE131840, ... | |
medium_hidden_intermediate_00802 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to schizophrenia via association. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 3.92 and an adjusted p-value of 0.0262. Which protein is encoded by... | Homeobox protein DLX-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to schizophrenia via asso... | |
medium_hidden_intermediate_00804 | Measles morbillivirus upregulates a gene that enables chromatin binding. In study GSE131840, one such gene exhibits a log2 fold change of approximately 2.17 and an adjusted p-value of 0.0003024. Which protein is encoded by this specific gene? | Zinc finger protein Pegasus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00804","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables chromatin binding. In study GSE131840, one such gene exhibits a log2 f... | |
medium_hidden_intermediate_00805 | Hepacivirus C upregulates a gene that participates in Developmental Biology. Evidence for this gene reports a log2 fold change of 2.235 and an adjusted p-value of 0.02508. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00805","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Developmental Biology. Evidence for this gene reports a log2 fold chan... | |
medium_hidden_intermediate_00806 | Human immunodeficiency virus 1 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 2.34 and an adjusted p-value of approximately 0.0032. Which biological process is this gene involved in? | T cell mediated immunity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene in... | |
medium_hidden_intermediate_00808 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes, which in turn encode proteins that bind to UBE2A. One such intermediate gene exhibits a log2 fold change of approximately 1.674 and an adjusted p-value of 0.003141. Which protein is encoded by this spec... | SPRY domain-containing SOCS box protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes, which ... | |
medium_hidden_intermediate_00811 | Cardiovirus A downregulates a gene that participates in post-translational protein modification. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibits a log2 fold change of approximately -1.81 and an adjusted p-value of 0.0119. Which protein is encoded by this specific gene? | DCN1-like protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00811","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that participates in post-translational protein modification. In a study of cervical aden... | |
medium_hidden_intermediate_00812 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (q) signalling events. One of these genes shows a log2 fold change of 1.141 and an adjusted p-value of 0.003728 in monocytes. Which disease is associated with this specific gene? | non-small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (q) signalling... | |
medium_hidden_intermediate_00813 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of actin filament polymerization. Evidence for this specific gene reports a log2 fold change of 8.844 and an adjusted p-value of 0.02634. Which protein is encoded by this gene? | Cdc42 effector protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of acti... | |
medium_hidden_intermediate_00816 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which in turn participates in the regulation of expression and function of Type I Classical Cadherins. This gene exhibited a log2 fold change of -3.396 and an adjusted p-value of 0.006248. Wh... | Krueppel-like factor 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_00817 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to MDM2. Experimental data for one such gene reports a log2 fold change of -2.981 and an adjusted p-value of 0.04725. Which protein is encoded by this gene? | Voltage-dependent calcium channel gamma-4 subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to MDM2. Experimental dat... | |
medium_hidden_intermediate_00820 | Two distinct histone H3 variant genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the activation of anterior HOX genes in hindbrain development during early embryogenesis. One of these genes was reported in a study of colonic adenocarcinoma cell lines (GSE148729) wit... | TRIM24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct histone H3 variant genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and part... | |
medium_hidden_intermediate_00822 | Hepacivirus C downregulates a gene that subsequently binds to NEDD8. Experimental data for this gene in peripheral blood mononuclear cells (study GSE119117) reports a log2 fold change of approximately -1.83 and an adjusted p-value of approximately 0.0298. What molecular function is enabled by this gene? | ubiquitin-like ligase-substrate adaptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00822","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that subsequently binds to NEDD8. Experimental data for this gene in peripheral blood mon... | |
medium_hidden_intermediate_00824 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables integrin binding. Experimental data for this gene reports a log2 fold change of approximately -2.33 and an adjusted p-value of approximately 0.05. Which protein is encoded by this gene? | Junctional adhesion molecule B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables integrin binding. Experimental data ... | |
medium_hidden_intermediate_00826 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that participates in inositol phosphate metabolism. This specific gene exhibited a log2 fold change of approximately 1.225 and an adjusted p-value of 0.01417. Which protein is encoded by this gene? | Inositol polyphosphate multikinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00826","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that participates i... | |
medium_hidden_intermediate_00829 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Bile acid and bile salt metabolism. Evidence for this gene reports a log2 fold change of approximately 1.313 and an adjusted p-value of 0.00602. Which biological process is this gene involved in? | regulation of cholesterol transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Bile acid and bile salt m... | |
medium_hidden_intermediate_00830 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of certain genes located in the Golgi apparatus. One such gene exhibits a log2 fold change of -1.315 and an adjusted p-value of 0.02924. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of certain... | |
medium_hidden_intermediate_00832 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and participates in cargo trafficking to the periciliary membrane. Evidence for this gene reports a log2 fold change of -1.488 and an adjusted p-value of 0.009408. Which protein is encoded by this gene? | Exocyst complex component 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and participates in car... | |
medium_hidden_intermediate_00833 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables ubiquitin protein ligase binding. Evidence for this gene reports a log2 fold change of approximately 1.044 and an adjusted p-value of 0.02917. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00833","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables ubiquitin protein ligase binding. Evid... | |
medium_hidden_intermediate_00834 | Lung vasculature is a subtype of two distinct anatomical categories, both of which are subtypes of vasculature. One of these categories is described by the evidence: 'The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.' Which anatomical structure is the part-of target for t... | organ | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Lung vasculature is a subtype of two distinct anatomical categories, both of which are subtypes of vasculature. One of these... | |
medium_hidden_intermediate_00835 | Two distinct proteins are known to bind both CRKL and PIK3R1. Experimental evidence indicates that stimulation of human embryonic kidney cells (HEK293) with hepatocyte growth factor (HGF) results in the association of one of these proteins with CRKL. Which disease is linked to this specific protein through genomic alte... | congestive heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00835","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins are known to bind both CRKL and PIK3R1. Experimental evidence indicates that stimulation of human embr... | |
medium_hidden_intermediate_00838 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with cardiomyopathy. Transcriptomic data for this gene in sclera cells from study GSE164073 reports a log2 fold change of approximately 1.142 and an adjusted p-value of 0.003781. Which protein is encoded by this gene? | Ran guanine nucleotide release factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00838","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with cardiomyopathy. Transc... | |
medium_hidden_intermediate_00840 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in Rab regulation of trafficking. This gene exhibited a log2 fold change of approximately -1.156 and an adjusted p-value of 0.03807. Which biological process is this gene involved... | exocytosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene t... | |
medium_hidden_intermediate_00843 | In a study of monocytic leukemia cell lines (GSE114966), Human alphaherpesvirus 1 infection was found to upregulate a specific gene that enables chromatin binding. This gene exhibited a log2 fold change of 2.640 and an adjusted p-value of 0.007482. Which protein is encoded by this gene? | Treslin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of monocytic leukemia cell lines (GSE114966), Human alphaherpesvirus 1 infection was found to upregulate a specif... | |
medium_hidden_intermediate_00845 | A gene is upregulated by Measles morbillivirus and participates in the Immune System. Experimental data for this gene reports a log2 fold change of 2.347 and an adjusted p-value of 0.00798. Which protein is encoded by this gene? | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00845","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in the Immune System. Experimental data for this gene report... | |
medium_hidden_intermediate_00846 | Zika virus downregulates a gene that interacts with SKP1. In glioma stem cells, one such gene exhibits a log2 fold change of -2.655 and an adjusted p-value of 0.00257. Which protein is encoded by this gene? | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with SKP1. In glioma stem cells, one such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_00847 | Enterovirus A upregulates a specific gene that is located in blood microparticles. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 2.92 and an adjusted p-value of approximately 0.0095. Which biological process is this gene involved in? | spermatogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that is located in blood microparticles. Experimental data for this gene in rhabdo... | |
medium_hidden_intermediate_00848 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and enables glutathione transferase activity. This specific gene exhibits a log2 fold change of approximately 1.157 and an adjusted p-value of 0.002251. Which protein is encoded by this gene? | Glutathione S-transferase Mu 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and enables glutathione trans... | |
medium_hidden_intermediate_00849 | A gene associated with germ cells via a marker relationship is involved in the positive regulation of DNA-templated transcription. Evidence regarding one such gene states: 'We show here that the potent co-activating properties of the protein encoded by this gene on the histone H4 gene promoter, which are evident in the... | Histone H4 transcription factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene associated with germ cells via a marker relationship is involved in the positive regulation of DNA-templated transcri... | |
medium_hidden_intermediate_00850 | Rhinovirus A infection leads to the downregulation of specific genes that are enriched in intermediate monocytes. One such gene exhibits a log2 fold change of approximately -1.15 and an adjusted p-value of approximately 7.9e-05 in cytotoxic T-lymphocytes. Which protein is encoded by this gene? | CMRF35-like molecule 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of specific genes that are enriched in intermediate monocytes. One such g... | |
medium_hidden_intermediate_00852 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and subsequently interacts with SMAD3. Experimental data for this gene reports a log2 fold change of -1.342 and an adjusted p-value of 0.03521. Which protein is encoded by this gene? | Casein kinase I isoform gamma-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00852","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and subseque... | |
medium_hidden_intermediate_00854 | In a study of non-small cell lung adenocarcinoma cell lines, a specific gene is downregulated by Influenza A virus and enables identical protein binding. This gene exhibits a log2 fold change of approximately -1.146 and an adjusted p-value of 1.681e-05. Which disease is associated with this gene? | ovarian clear cell adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines, a specific gene is downregulated by Influenza A virus and enabl... | |
medium_hidden_intermediate_00855 | Measles morbillivirus upregulates a gene that participates in Cell-Cell communication. Experimental data for this gene shows a log2 fold change of 1.664 and an adjusted p-value of 0.0002991. Which biological process is this gene involved in? | protein localization to kinetochore | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in Cell-Cell communication. Experimental data for this gene shows... | |
medium_hidden_intermediate_00856 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the RHOA GTPase cycle. Evidence for one such gene reports a log2 fold change of 1.288 and an adjusted p-value of 0.01256. Which protein is encoded by that gene? | Rho GTPase-activating protein 30 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00856","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the RHOA GTPase cycle. Evidenc... | |
medium_hidden_intermediate_00858 | Zika virus downregulates a gene that enables protein serine/threonine kinase activity. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.275 and an adjusted p-value of 0.03271. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00858","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables protein serine/threonine kinase activity. In a study of glioma stem cells (GSE1... | |
medium_hidden_intermediate_00861 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently interact with GRSF1. One such gene exhibited a log2 fold change of approximately 1.066 and an adjusted p-value of 2.677e-05. Which protein is encoded by this specific gene? | Double-stranded RNA-binding protein Staufen homolog 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00861","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_00863 | Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to pituitary gland adenoma via an association relationship. One of these genes was reported in a study (GSE108897) on macrophages with a log2 fold change of approximately 1.192 and an adjusted p-value of 0.004409. Which protein ... | Disintegrin and metalloproteinase domain-containing protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00863","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to pituitary gland adenoma via a... | |
medium_hidden_intermediate_00864 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in diseases of signal transduction by growth factor receptors and second messengers. This specific gene exhibited a log2 fold change of -1.766 and an adjusted p-value of 0.004742. Which molecular fun... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_00865 | RAB27A interacts with a protein that enables protein binding. Evidence regarding one such interacting partner states: 'Screening its possible Rab partner by a yeast two-hybrid system revealed that an amino-terminal zinc-finger domain of granuphilin interacts with Rab27a.' Which protein is encoded by the gene correspond... | Synaptotagmin-like protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RAB27A interacts with a protein that enables protein binding. Evidence regarding one such interacting partner states: 'Scree... | |
medium_hidden_intermediate_00866 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to the Cajal body via a 'located in' relationship. One of these genes has been reported in a study (GSE157852) involving choroid plexus epithelium cells, with a log2 fold change of approximat... | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_00868 | Zika virus downregulates a gene that interacts with PABPC4. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of approximately -1.70 and an adjusted p-value of approximately 0.00595. Which protein is encoded by this gene? | Protein LSM12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with PABPC4. In glioma stem cells (study GSE114907), one such gene exhibits a... | |
medium_hidden_intermediate_00869 | Zika virus downregulates a specific gene, which in turn interacts with CCNB1. Experimental data for this intermediate gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.83 and an adjusted p-value of 0.019. Which cellular component is this intermediate gene located in? | nuclear pore nuclear basket | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CCNB1. Experimental data for this intermediate gene i... | |
medium_hidden_intermediate_00870 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn enables FMN binding. This gene exhibited a log2 fold change of approximately -3.78 and an adjusted p-value of 0.031. Which protein is encoded by this gene? | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00870","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn e... | |
medium_hidden_intermediate_00871 | Zika virus downregulates a gene that is involved in vesicle-mediated transport. Evidence for this gene reports a log2 fold change of -1.021 and an adjusted p-value of 0.01753. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00871","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in vesicle-mediated transport. Evidence for this gene reports a log2 fold c... | |
medium_hidden_intermediate_00872 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metabolism. Transcriptomic data for this gene shows a log2 fold change of -1.217 and an adjusted p-value of 0.002703. Which cellular component is this gene located in? | Golgi apparatus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metab... | |
medium_hidden_intermediate_00874 | Zika virus downregulates a specific gene that participates in intra-Golgi and retrograde Golgi-to-ER traffic. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -1.934 and an adjusted p-value of 0.01171. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in intra-Golgi and retrograde Golgi-to-ER traffic. Experimental d... | |
medium_hidden_intermediate_00875 | Zika virus downregulates a gene that is involved in the mitotic cell cycle. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of approximately -1.26 and an adjusted p-value of 0.0079. Which protein is encoded by this specific gene? | BRISC complex subunit Abraxas 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the mitotic cell cycle. In a study of glioma stem cells (GSE114907), one... | |
medium_hidden_intermediate_00876 | A gene is upregulated by Measles morbillivirus and participates in Signaling by ROBO receptors. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) show a log2 fold change of approximately 1.12 and an adjusted p-value of approximately 0.0002. Which cellular component is this gene located in? | cytosolic large ribosomal subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Signaling by ROBO receptors. Experimental data for this g... | |
medium_hidden_intermediate_00878 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in Signaling by NTRKs. This specific gene exhibits a log2 fold change of -1.554 and an adjusted p-value of 0.01504. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_00879 | Two genes are structurally linked to Pegivirus C via downregulation and to CCNF via interaction. One of these genes exhibits a log2 fold change of -1.619 and an adjusted p-value of 0.04991 in peripheral blood mononuclear cells (study GSE131504). Which disease is associated with this specific gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00879","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to CCNF via interaction. One of these genes exhibits... | |
medium_hidden_intermediate_00880 | In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a specific gene, which in turn interacts with EIF3G. The expression data for this gene shows a log2 fold change of approximately 1.05 and an adjusted p-value of 9.589e-08. Which protein is encoded by this gene? | Eukaryotic translation initiation factor 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a specific gene, which... | |
medium_hidden_intermediate_00881 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus serves as a biomarker for diabetes mellitus. This specific gene exhibits a log2 fold change of approximately 2.07 and an adjusted p-value of approximately 3.09e-08. Which protein is encoded by this gene? | Hexokinase-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00881","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus serves as a biomarker for ... | |
medium_hidden_intermediate_00882 | Measles morbillivirus upregulates a gene that is involved in the defense response to virus. Evidence for one such gene reports a log2 fold change of 2.457 and an adjusted p-value of 0.001266. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00882","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the defense response to virus. Evidence for one such gene repor... | |
medium_hidden_intermediate_00883 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in the MyD88 cascade initiated on the plasma membrane. One of these genes exhibits a log2 fold change of 1.291 and an adjusted p-value of 0.0004056 in macrophages. Which disease is associated with this specific gene? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00883","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in the MyD88 cascade initiated on the plasma mem... | |
medium_hidden_intermediate_00884 | CHMP5 interacts with a protein that is involved in protein binding. Experimental evidence indicates that this protein forms heteromeric complexes with VPS4-A. Which gene encodes this protein? | Vacuolar protein sorting-associated protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00884","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CHMP5 interacts with a protein that is involved in protein binding. Experimental evidence indicates that this protein forms ... | |
medium_hidden_intermediate_00885 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that is located in the extracellular region. One such gene exhibited a log2 fold change of -5.378 and an adjusted p-value of 0.00643. Which protein is encoded by this specific gene? | Insulin-like growth factor-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00885","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that is located in th... | |
medium_hidden_intermediate_00887 | Measles morbillivirus upregulates a gene that is located in the cytoplasmic vesicle. Evidence for one such gene reports a log2 fold change of 1.323 and an adjusted p-value of 0.00342. Which protein is encoded by that gene? | Ankyrin repeat domain-containing protein 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00887","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the cytoplasmic vesicle. Evidence for one such gene reports a lo... | |
medium_hidden_intermediate_00889 | Two genes are linked to Measles morbillivirus via upregulation and to ovarian neoplasm via biomarker association. One of these genes has an associated study reporting a log2 fold change of approximately 2.97 and an adjusted p-value of approximately 0.0031. Which protein is encoded by this specific gene? | Histone H2A type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Measles morbillivirus via upregulation and to ovarian neoplasm via biomarker association. One of the... | |
medium_hidden_intermediate_00890 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and enabling histone H4K20me2 reader activity was found to have a log2 fold change of 3.278 and an adjusted p-value of 7.65e-06. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and enabling histone H4K20... | |
medium_hidden_intermediate_00892 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables transmembrane signaling receptor activity. Evidence for this gene reports a log2 fold change of 1.324 and an adjusted p-value of 1.67e-13. Which disease is associated with this gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables transmembrane signaling receptor ... | |
medium_hidden_intermediate_00893 | Human alphaherpesvirus 1 upregulates a gene that is involved in the positive regulation of DNA-templated transcription. Evidence for one such gene reports a log2 fold change of 1.010 and an adjusted p-value of 0.02924. Which protein is encoded by that gene? | Mediator of RNA polymerase II transcription subunit 30 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00893","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is involved in the positive regulation of DNA-templated transcription. Evid... | |
medium_hidden_intermediate_00894 | In a study of rhabdomyosarcoma cells (GSE103308), a specific gene is downregulated by Enterovirus A and participates in post-translational protein modification. This gene exhibits a log2 fold change of -1.149 and an adjusted p-value of 0.01293. Which gene interacts with this identified entity? | ALG2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00894","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a specific gene is downregulated by Enterovirus A and participates in post... | |
medium_hidden_intermediate_00895 | Measles morbillivirus downregulates a specific gene that subsequently interacts with CUL3. Experimental data for this gene indicates a log2 fold change of approximately -1.002 and an adjusted p-value of 0.007682. Which biological process is this gene involved in? | negative regulation of apoptotic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00895","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a specific gene that subsequently interacts with CUL3. Experimental data for this gene i... | |
medium_hidden_intermediate_00897 | Zika virus downregulates a gene that is located in the endosome. Evidence for one such gene reports a log2 fold change of -1.021 and an adjusted p-value of 0.01753. Which disease is associated with that gene? | adenoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the endosome. Evidence for one such gene reports a log2 fold change of -1... | |
medium_hidden_intermediate_00901 | Hepacivirus C upregulates a gene that is involved in the activation of GTPase activity. Evidence for this gene reports a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.0042. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the activation of GTPase activity. Evidence for this gene reports a log... | |
medium_hidden_intermediate_00903 | Zika virus downregulates a gene that is associated with gastric cancer. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.792 and an adjusted p-value of 0.02284. Which protein is encoded by this gene? | Protein lin-9 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00903","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with gastric cancer. Experimental data for this gene in glioma stem cells... | |
medium_hidden_intermediate_00904 | Rectal neoplasms can be localized to various anatomical structures that are derived from the mesoderm. One such structure is described as a pair of glandular pouches located on either side of the male reproductive tract, posterolateral to the urinary bladder, which secrete a sugar- and protein-containing fluid into the... | internal male genitalia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rectal neoplasms can be localized to various anatomical structures that are derived from the mesoderm. One such structure is... | |
medium_hidden_intermediate_00905 | Zika virus infection leads to the downregulation of specific genes whose protein products are located in the actin cytoskeleton. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.797 and an adjusted p-value of 0.01255. Which protein is encoded by this specific gene? | Coronin-2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00905","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of specific genes whose protein products are located in the actin cytoskele... | |
medium_hidden_intermediate_00907 | In a study of Measles morbillivirus infection, a specific gene is downregulated and serves as a biomarker for schizophrenia. Evidence for this gene reports a log2 fold change of approximately -1.23 and an adjusted p-value of 0.00269. Which protein is encoded by this gene? | Phospholemman | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated and serves as a biomarker for schizophrenia.... | |
medium_hidden_intermediate_00908 | Enterovirus A is known to downregulate certain genes that are located in the plasma membrane. One such gene exhibits a log2 fold change of approximately -2.006 and an adjusted p-value of 0.01276 in rhabdomyosarcoma cells. Which disease is associated with this specific gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00908","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is known to downregulate certain genes that are located in the plasma membrane. One such gene exhibits a log2 ... | |
medium_hidden_intermediate_00909 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the androgen receptor signaling pathway. One of these genes exhibits a log2 fold change of -1.154 and an adjusted p-value of 0.01184 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the androgen recept... | |
medium_hidden_intermediate_00911 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the defense response. Evidence for this specific gene reports a log2 fold change of 1.207 and an adjusted p-value of 0.01067. Which protein is encoded by this gene? | Cystatin-C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00911","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the defense response. Evidence ... | |
medium_hidden_intermediate_00914 | A protein entity interacts with pyruvate kinase M2 (PKM2) and is located in the nucleus. Evidence indicates that this entity interacts directly with PKM2 to modulate metabolic flux in cancer cells. Which cell type is enriched in this specific interacting entity? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00914","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein entity interacts with pyruvate kinase M2 (PKM2) and is located in the nucleus. Evidence indicates that this entity... | |
medium_hidden_intermediate_00915 | Zika virus downregulates a gene that participates in PI Metabolism. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.496 and an adjusted p-value of 0.001973. Which protein is encoded by this gene? | Phosphatidylinositol 4-kinase type 2-beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in PI Metabolism. Evidence for this gene in glioma stem cells (study GSE11... | |
medium_hidden_intermediate_00916 | Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of approximately 2.73 and an adjusted p-value of approximately 1.00e-05 in a specific study. Which disease is associated with this specific gene? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00916","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhib... | |
medium_hidden_intermediate_00917 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene that participates in the Adaptive Immune System. This gene exhibits a log2 fold change of approximately -2.245 and an adjusted p-value of 0.002089. Which biological process is this gene involv... | negative regulation of antigen processing and presentation of peptide antigen via MHC class II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00917","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific g... | |
medium_hidden_intermediate_00918 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with hyperplasia. One of these genes was reported in a study on cardiomyocyte cell lines (GSE151879) with a log2 fold change of 2.515 and an adjusted p-value of 0.007545. Which protein interacts with this specific gen... | BTRC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00918","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with hyperplasia. One... | |
medium_hidden_intermediate_00921 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes that participate in Phase II conjugation of compounds. One such gene exhibits a log2 fold change of -3.243 and an adjusted p-value of 0.0001302. Which biological process is this specific gene involved... | nicotinamide metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes that... | |
medium_hidden_intermediate_00922 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to glutathione transferase activity via an 'enables' relationship. One of these genes is reported in a study (GSE164073) involving sclera cells, with a log2 fold change of -1.462 and an adju... | hepatitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00922","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_00923 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Evidence for this specific gene reports a log2 fold change of 2.870 and an adjusted p-value of 0.01008. Which protei... | Cas scaffolding protein family member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00923","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in the positive re... | |
medium_hidden_intermediate_00924 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with GID8. One of these genes exhibits a log2 fold change of -2.357 and an adjusted p-value of 0.03143 in bronchial epithelial cells. Which biological process is this specific gene involved in? | regulation of cell cycle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00924","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with GID8. One of these ge... | |
medium_hidden_intermediate_00925 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product is located in the mitochondrial membrane. This gene exhibits a log2 fold change of approximately 1.022 and an adjusted p-value of 4.865e-10. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 7A2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00925","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product is ... | |
medium_hidden_intermediate_00928 | Human immunodeficiency virus 1 downregulates a gene that is involved in the negative regulation of smooth muscle cell migration. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of -1.515 and an adjusted p-value of 0.04103. Which protein is encoded by this gene? | Slit homolog 2 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00928","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the negative regulation of smooth muscle cell migrat... | |
medium_hidden_intermediate_00929 | Hepacivirus C downregulates a gene that participates in factors involved in megakaryocyte development and platelet production. Evidence for one such gene reports a log2 fold change of -2.779 and an adjusted p-value of 0.01464. Which disease is associated with that gene? | cholestasis, progressive familial intrahepatic, 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00929","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in factors involved in megakaryocyte development and platelet productio... | |
medium_hidden_intermediate_00930 | Rift Valley fever phlebovirus upregulates a gene that participates in the metabolism of proteins. In a study of SAEC cells (GSE102481), one such gene showed a log2 fold change of 1.029 and an adjusted p-value of 0.04099. Which disease is associated with this specific gene? | proteinuria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that participates in the metabolism of proteins. In a study of SAEC cells (... | |
medium_hidden_intermediate_00932 | Zika virus downregulates a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -3.61 and an adjusted p-value of 0.0186. Which cellular component is this gene located ... | Cul5-RING ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00932","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic p... | |
medium_hidden_intermediate_00933 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of cell migration. Evidence for one such gene reports a log2 fold change of -2.042 and an adjusted p-value of 0.000107. Which disease is genetically associated with that gene? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of ce... |
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