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medium_hidden_intermediate_00635 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with adenocarcinoma. One of these genes exhibits a log2 fold change of approximately 8.22 and an adjusted p-value of 0.0317 in lung cells. Which protein is encoded by this specific gene? | Beta-defensin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00635","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with adenocarcinoma. O... | |
medium_hidden_intermediate_00636 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and its product is located in the cytoplasm. Evidence for this gene reports a log2 fold change of approximately -1.42 and an adjusted p-value of 0.00298. Which protein is encoded by this gene? | Serine/threonine-protein kinase VRK2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00636","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and... | |
medium_hidden_intermediate_00639 | In a study of macrophages (GSE108897), two genes are identified as being upregulated by Human immunodeficiency virus 1 and participating in the Toll Like Receptor 3 (TLR3) Cascade. One of these genes exhibits a log2 fold change of approximately 2.84 and an adjusted p-value of 0.0487. Which protein is encoded by this sp... | Dual specificity mitogen-activated protein kinase kinase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00639","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), two genes are identified as being upregulated by Human immunodeficiency virus 1 and p... | |
medium_hidden_intermediate_00640 | Human respirovirus 3 upregulates a gene that is located in the nucleus. In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), this gene exhibited a log2 fold change of 1.249 and an adjusted p-value of 0.03663. Which protein is encoded by this gene? | N(6)-adenine-specific methyltransferase METTL4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00640","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human respirovirus 3 upregulates a gene that is located in the nucleus. In a study of non-small cell lung adenocarcinoma cel... | |
medium_hidden_intermediate_00642 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its protein product enables calcium ion binding. Evidence for this gene reports a log2 fold change of -1.974 and an adjusted p-value of 5.651e-05. Which protein is encoded by this gene? | Signal peptide, CUB and EGF-like domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00642","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its prot... | |
medium_hidden_intermediate_00643 | Two biological processes are structurally positioned between 'positive regulation of glycine secretion, neurotransmission' and 'positive regulation of synaptic transmission' via 'is a' relationships. One of these processes is defined by the evidence: 'Any process that activates or increases the frequency, rate or exten... | neurotransmitter secretion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two biological processes are structurally positioned between 'positive regulation of glycine secretion, neurotransmission' a... | |
medium_hidden_intermediate_00644 | A gene is downregulated by Cardiovirus A and is enriched in eosinophils. Transcriptomic data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.38 and an adjusted p-value of approximately 0.01. Which disease is associated with this gene? | peritonitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00644","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and is enriched in eosinophils. Transcriptomic data for this gene in a cervical ade... | |
medium_hidden_intermediate_00646 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which subsequently interacts with TP53. This gene exhibits a log2 fold change of approximately -2.17 and an adjusted p-value of 0.018. In which cellular component is this gene located? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_00647 | Two genes are downregulated by Influenza A virus and enriched in naive B cells. One of these genes exhibits a log2 fold change of -1.008 and an adjusted p-value of 4.235e-07 in a specific study. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00647","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Influenza A virus and enriched in naive B cells. One of these genes exhibits a log2 fold chan... | |
medium_hidden_intermediate_00649 | Human immunodeficiency virus 1 downregulates a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Evidence from a study on macrophages (GSE108897) reports that this gene has a log2 fold change of -1.135 and an adjusted p-value of 0.01015. Which protein is encoded by this gene? | Dolichyl-phosphate beta-glucosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00649","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the synthesis of substrates in N-glycan biosynthesi... | |
medium_hidden_intermediate_00651 | In a study of Dengue virus infection in hepatoma cells, a specific gene is upregulated by the virus and its product is located in the plasma membrane. This gene exhibits a log2 fold change of approximately 2.28 and an adjusted p-value of 0.04055. Which protein is encoded by this gene? | Interleukin-17 receptor B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Dengue virus infection in hepatoma cells, a specific gene is upregulated by the virus and its product is locat... | |
medium_hidden_intermediate_00652 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Interferon gamma signaling. Experimental data for this gene shows a log2 fold change of -1.587 and an adjusted p-value of 0.0204. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Interferon gamma signal... | |
medium_hidden_intermediate_00655 | In a study of foreskin fibroblast cells, a gene is identified as being downregulated by Human betaherpesvirus 5 and participating in Glycosphingolipid metabolism. This specific gene exhibits a log2 fold change of -1.938 and an adjusted p-value of 0.04101. Which protein is encoded by this gene? | Ceramide kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of foreskin fibroblast cells, a gene is identified as being downregulated by Human betaherpesvirus 5 and particip... | |
medium_hidden_intermediate_00656 | A gene expressed in progenitor cells and capable of protein binding is the subject of evidence stating it interacts with galectin-1 (Gal-1), a 14-kDa secreted protein. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00656","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in progenitor cells and capable of protein binding is the subject of evidence stating it interacts with gal... | |
medium_hidden_intermediate_00658 | A gene serves as a marker for Natural killer T (NKT) cells and is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for one such gene reports a mean expression of 17.99 TPM, a z-score of 2.27, and a fold enrichment of 7.26. Which disease is associated with that gene? | retinal degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Natural killer T (NKT) cells and is enriched in Mucosa-associated invariant T (MAIT) cells. Ev... | |
medium_hidden_intermediate_00659 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the Immune System. Experimental evidence for this gene reports a log2 fold change of 1.085 and an adjusted p-value of 0.01309. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the Immune System. Experimental evidence for this gene... | |
medium_hidden_intermediate_00660 | In a study of foreskin fibroblast cell lines (GSE111036), Human betaherpesvirus 5 infection leads to the downregulation of a specific gene, which in turn interacts with STK4. The expression data for this intermediate gene shows a log2 fold change of -1.933 and an adjusted p-value of 0.0288. Which protein is encoded by ... | Actin-binding LIM protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00660","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of foreskin fibroblast cell lines (GSE111036), Human betaherpesvirus 5 infection leads to the downregulation of a... | |
medium_hidden_intermediate_00661 | Zaire ebolavirus infection leads to the upregulation of certain genes that participate in signal transduction. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated gene exhibited a log2 fold change of approximately 1.076 and an adjusted p-value of 0.01493. Which protein is encoded by this sp... | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of certain genes that participate in signal transduction. In a study of... | |
medium_hidden_intermediate_00662 | Zika virus downregulates a specific gene, which in turn interacts with BAG3. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.10 and an adjusted p-value of approximately 0.0026. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00662","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with BAG3. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_00663 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with MAP1B. Evidence for one such gene reports a log2 fold change of -1.067 and an adjusted p-value of 0.03769. Which protein is encoded by that gene? | Ras association domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with MAP1B. Evidence for one such ... | |
medium_hidden_intermediate_00664 | Two genes are identified as markers of microglial cells and are both located in the extracellular region. One of these genes is associated with evidence stating that 'Both proteins were secreted into the culture medium.' Which cell type is enriched for this specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers of microglial cells and are both located in the extracellular region. One of these genes... | |
medium_hidden_intermediate_00665 | Hepacivirus C upregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evidence for one such gene reports a log2 fold change of 1.162 and an adjusted p-value of 0.007041. Which gene interacts with the gene identified by this evidence? | ZBTB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evid... | |
medium_hidden_intermediate_00666 | Measles morbillivirus downregulates a gene that is located in the plasma membrane. Evidence for one such gene reports a log2 fold change of -1.287 and an adjusted p-value of 0.02112. Which disease is associated with that gene? | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00666","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that is located in the plasma membrane. Evidence for one such gene reports a log2... | |
medium_hidden_intermediate_00667 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to cervical carcinoma via an association relationship. One of these genes is reported in a study (GSE151879) involving cardiomyocyte cell lines, with a log2 fold change of approximately 1.56 a... | Thyrotroph embryonic factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_00668 | Zika virus downregulates a specific gene, which is enriched in memory B cells. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.934 and an adjusted p-value of 0.02144. Which protein is encoded by this gene? | Syntabulin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00668","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is enriched in memory B cells. Experimental data for this gene in glioma ste... | |
medium_hidden_intermediate_00669 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the response to oxidative stress was found to have a log2 fold change of approximately 1.74 and an adjusted p-value of approximately 1.88e-12. Which disease is associated with genomic alterations in this sp... | chronic renal failure syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00669","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the respon... | |
medium_hidden_intermediate_00670 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene was found to be upregulated by the virus and enriched in non-classical monocytes. This gene exhibited a log2 fold change of 1.291 and an adjusted p-value of 8.116e-05. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene was found to be upre... | |
medium_hidden_intermediate_00671 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that participate in immune system processes. One such gene exhibits a log2 fold change of approximately -1.406 and an adjusted p-value of 0.02492. Which protein is encoded by this specific gene? | Transcriptional enhancer factor TEF-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_00672 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate specific genes that participate in TRAF6-mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. One such gene exhibited a log2 fold change of -1.891 and an adjusted p-value of 0.03703. Which ... | Ribosomal protein S6 kinase alpha-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate specific gen... | |
medium_hidden_intermediate_00673 | Human betaherpesvirus 5 is linked to mammary neoplasms in animals via the upregulation of specific genes. One such gene exhibits a log2 fold change of 4.369 and an adjusted p-value of 0.0006947 in experimental data. Which protein is encoded by this specific gene? | Transcription factor ETV7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00673","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to mammary neoplasms in animals via the upregulation of specific genes. One such gene exhi... | |
medium_hidden_intermediate_00674 | In a study of bronchial epithelial cells (GSE150819), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in cilium assembly showed a log2 fold change of 1.257 and an adjusted p-value of 0.03138. Which disease is associated with this gene as a biomarker? | ciliopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE150819), a gene upregulated by Severe acute respiratory syndrome-related corona... | |
medium_hidden_intermediate_00675 | Cardiovirus A downregulates a gene that is located in the extracellular exosome. Evidence for this gene reports a log2 fold change of -1.837 and an adjusted p-value of 0.01386. Which protein is encoded by this gene? | Actin-binding protein WASF3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is located in the extracellular exosome. Evidence for this gene reports a log2 fold ... | |
medium_hidden_intermediate_00676 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in glycosaminoglycan metabolism. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of approximately -1.305 and an adjusted p-value of 0.002315. Which protein is encoded by this specific gene? | Heparan-sulfate 6-O-sulfotransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00676","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in glycosaminoglycan metabolism. In a study usi... | |
medium_hidden_intermediate_00677 | Zaire ebolavirus upregulates a gene that is located in the nucleus. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated nuclear gene showed a log2 fold change of 1.388 and an adjusted p-value of 0.04666. Which biological process is this specific gene involved in? | negative regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is located in the nucleus. In a study of retinal pigment epithelium cells (GSE10083... | |
medium_hidden_intermediate_00679 | Two genes are downregulated by Pegivirus C and interact with DDX18. One of these genes exhibits a log2 fold change of approximately -1.998 and an adjusted p-value of 0.01251 in peripheral blood mononuclear cells. Which protein is encoded by this specific gene? | RNA-binding protein 28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00679","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with DDX18. One of these genes exhibits a log2 fold change of approx... | |
medium_hidden_intermediate_00680 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Innate Immune System. One such gene exhibits a log2 fold change of approximately 1.01 and an adjusted p-value of approximately 0.0082. Which biological process is this specific gene involved in? | positive regulation of autophagy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Innate Imm... | |
medium_hidden_intermediate_00681 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with CUL2. Evidence for this gene shows a log2 fold change of approximately -1.81 and an adjusted p-value of 0.0119. Which protein is encoded by this gene? | DCN1-like protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_00682 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with FGFR1. This gene exhibited a log2 fold change of approximately -1.194 and an adjusted p-value of 0.0001877. Which protein is encoded by this gene? | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_00683 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables inward rectifier potassium channel activity. One such gene exhibited a log2 fold change of 6.845 and an adjusted p-value of 0.0003737. Which biological process is this specific gene involved... | potassium ion transmembrane transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_00684 | In a study of macrophages (GSE108897), two genes are downregulated by Human immunodeficiency virus 1 and are involved in mitochondrion organization. One of these genes exhibits a log2 fold change of approximately -1.04 and an adjusted p-value of approximately 0.013. What molecular function is enabled by this specific g... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00684","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), two genes are downregulated by Human immunodeficiency virus 1 and are involved in mit... | |
medium_hidden_intermediate_00686 | Rhinovirus A infection leads to the upregulation of certain genes that participate in cellular responses to stimuli. In a study of cytotoxic T-lymphocytes (GSE106475), one such upregulated gene exhibited a log2 fold change of approximately 1.333 and an adjusted p-value of 0.02871. Which protein is encoded by this speci... | Adenylate cyclase type 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00686","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the upregulation of certain genes that participate in cellular responses to stimuli. In a st... | |
medium_hidden_intermediate_00688 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to RFC4. Experimental data for one such gene reports a log2 fold change of -1.456 and an adjusted p-value of 0.01697. Which protein is encoded by this gene? | DNA polymerase alpha subunit B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to RFC4. Experimental dat... | |
medium_hidden_intermediate_00690 | Measles morbillivirus upregulates a gene that subsequently interacts with EGFR. Experimental data for one such gene reports a log2 fold change of approximately 2.50 and an adjusted p-value of 0.0001076. Which protein is encoded by this gene? | Transforming acidic coiled-coil-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that subsequently interacts with EGFR. Experimental data for one such gene reports ... | |
medium_hidden_intermediate_00692 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with CUL3. Experimental data for this gene indicates a log2 fold change of -1.230 and an adjusted p-value of 0.001266. In which cell type is this gene enriched? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00692","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with CUL3. Experimental data for this gene ... | |
medium_hidden_intermediate_00693 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the peroxisome. Evidence for this gene reports a log2 fold change of 2.897 and an adjusted p-value of 0.02629. Which protein is encoded by this gene? | Hydroxysteroid dehydrogenase-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the peroxisome. Evidence fo... | |
medium_hidden_intermediate_00694 | Zika virus downregulates a gene that interacts with GOLGA2. Experimental data for this gene in glioma stem cells (study GSE114907) shows a log2 fold change of -1.724 and an adjusted p-value of 0.04202. Which protein is encoded by this gene? | Ubinuclein-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00694","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with GOLGA2. Experimental data for this gene in glioma stem cells (study GSE1... | |
medium_hidden_intermediate_00696 | Two genes are each upregulated by Human immunodeficiency virus 1 and associated with stroke disorder. One of these genes exhibits a log2 fold change of approximately 1.60 and an adjusted p-value of 0.0077 in macrophages (study GSE108897). Which protein interacts with this specific gene? | S100A6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Human immunodeficiency virus 1 and associated with stroke disorder. One of these genes exh... | |
medium_hidden_intermediate_00697 | A gene is upregulated by Enterovirus A and involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene in rhabdomyosarcoma cells reports a log2 fold change of approximately 1.256 and an adjusted p-value of 0.01792. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Enterovirus A and involved in the positive regulation of transcription by RNA polymerase II. Experi... | |
medium_hidden_intermediate_00698 | Zaire ebolavirus downregulates a specific gene that is enriched in basophils. Transcriptomic data for this gene in retinal pigment epithelium cells (study GSE100839) reports a log2 fold change of approximately -1.096 and an adjusted p-value of 0.019. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a specific gene that is enriched in basophils. Transcriptomic data for this gene in retinal p... | |
medium_hidden_intermediate_00699 | A gene is downregulated by Primate bocaparvovirus 1 and participates in Membrane Trafficking. Experimental evidence for this gene reports a log2 fold change of -3.843 and an adjusted p-value of 0.00876. Which protein is encoded by this gene? | Charged multivesicular body protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in Membrane Trafficking. Experimental evidence for this... | |
medium_hidden_intermediate_00700 | Pegivirus C downregulates a gene that participates in SLC-mediated transport of inorganic anions. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) show a log2 fold change of -2.591 and an adjusted p-value of 0.02446. Which biological process is this gene involved in? | sulfate transmembrane transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in SLC-mediated transport of inorganic anions. Experimental data for this... | |
medium_hidden_intermediate_00701 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn interacts with RNF185. Experimental data for this gene shows a log2 fold change of -1.358 and an adjusted p-value of 0.04004. Which protein is encoded by this gene? | BRI3-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn interacts with RNF185. Experimental data ... | |
medium_hidden_intermediate_00702 | Human betaherpesvirus 5 is linked to breast carcinoma via an intermediate gene that it upregulates and which is associated with the disease. One such intermediate gene exhibits a log2 fold change of 3.857 and an adjusted p-value of 0.0001783 in a specific study. Which protein is encoded by this intermediate gene? | Protein LBH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to breast carcinoma via an intermediate gene that it upregulates and which is associated w... | |
medium_hidden_intermediate_00703 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Cyclin D associated events in G1. Evidence for one such gene reports a log2 fold change of -1.458 and an adjusted p-value of 0.0022. Which protein is encoded by that gene? | Cyclin-dependent kinase 4 inhibitor C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Cyclin D associated events i... | |
medium_hidden_intermediate_00705 | Human respirovirus 3 upregulates a gene that is located in the cytoplasm. Experimental data for this gene in non-small cell lung adenocarcinoma cell lines (study GSE147507) reports a log2 fold change of approximately 1.52 and an adjusted p-value of approximately 0.042. Which disease is associated with this gene? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human respirovirus 3 upregulates a gene that is located in the cytoplasm. Experimental data for this gene in non-small cell ... | |
medium_hidden_intermediate_00706 | Zika virus downregulates a gene that participates in hemostasis. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.464 and an adjusted p-value of 0.002876. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in hemostasis. In a study of glioma stem cells (GSE114907), this gene exhi... | |
medium_hidden_intermediate_00707 | A gene is upregulated by Vaccinia virus and participates in RHO GTPase Effectors. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.278 and an adjusted p-value of 1.441e-06. Which disease is associated with this gene through genomic alterations? | childhood acute lymphoblastic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in RHO GTPase Effectors. Experimental data for this gene in a cervi... | |
medium_hidden_intermediate_00709 | Two genes are each upregulated by Human alphaherpesvirus 1 and enriched in neutrophils. One of these genes has a reported log2 fold change of 1.353 and an adjusted p-value of 0.0227 in a monocytic leukemia cell line study. Which protein does this specific gene interact with? | CD7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Human alphaherpesvirus 1 and enriched in neutrophils. One of these genes has a reported lo... | |
medium_hidden_intermediate_00711 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with TP53. One of these genes exhibits a log2 fold change of 1.551 and an adjusted p-value of 1.095e-05 in macrophages. Which disease is associated with genomic alterations in this specific gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with TP53. One of these genes exhibits a log2 fold ... | |
medium_hidden_intermediate_00712 | Zika virus is reported to downregulate a specific gene, which is subsequently found to be enriched in Mucosa-associated invariant T (MAIT) cells. Experimental data for this gene in glioma stem cells indicates a log2 fold change of -1.245 and an adjusted p-value of 0.02146. Which protein is encoded by this gene? | EEF1A lysine methyltransferase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate a specific gene, which is subsequently found to be enriched in Mucosa-associated inva... | |
medium_hidden_intermediate_00713 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which is in turn enriched in conventional dendritic cells. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) indicates a log2 fold change of approximately -2.15 and an adjusted p-value of approximately 0.0047. Which c... | cytoskeleton | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which is in turn enriched in conventional dendritic cel... | |
medium_hidden_intermediate_00717 | Two genes are linked to Cardiovirus A via an upregulation relationship and to basophils via an enrichment relationship. One of these genes has a reported log2 fold change of 2.204 and an adjusted p-value of 0.001109 in cervical adenocarcinoma cell lines. Which protein is encoded by this specific gene? | Putative olfactory receptor 2I1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Cardiovirus A via an upregulation relationship and to basophils via an enrichment relationship. One ... | |
medium_hidden_intermediate_00719 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which in turn interacts with SLX4. This gene exhibits a log2 fold change of -1.438 and an adjusted p-value of 0.005087. Which protein is encoded by this gene? | Probable ATP-dependent RNA helicase DHX40 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00719","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_00720 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in intracellular pH reduction. One such gene exhibits a log2 fold change of approximately 1.407 and an adjusted p-value of 0.01463. Which protein is encoded by this specific gene? | Transmembrane protein 87A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00720","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus upregulates a gene that is inv... | |
medium_hidden_intermediate_00721 | Zika virus upregulates a specific gene that participates in the response of EIF2AK4 (GCN2) to amino acid deficiency. In a study of glioblastoma multiforme cancer stem cells (GSE102924), this gene exhibited a log2 fold change of approximately 2.63 and an adjusted p-value of 0.03339. Which disease is associated with this... | thymoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that participates in the response of EIF2AK4 (GCN2) to amino acid deficiency. In a st... | |
medium_hidden_intermediate_00722 | Pegivirus C is reported to downregulate a gene that is involved in Golgi to plasma membrane protein transport. Evidence for this specific gene shows a log2 fold change of -2.146 and an adjusted p-value of 0.0001853. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in Golgi to plasma membrane protein transport. Evidence for ... | |
medium_hidden_intermediate_00723 | Cisapride and Fostamatinib are both known to interact with a specific third drug. Clinical guidelines advise against coadministering cisapride with this drug, noting that montelukast serves as an alternative. What disease is this third drug indicated for? | asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cisapride and Fostamatinib are both known to interact with a specific third drug. Clinical guidelines advise against coadmin... | |
medium_hidden_intermediate_00725 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene that participates in the process 'PPARA activates gene expression'. This gene exhibited a log2 fold change of 1.348 and an adjusted p-value of 0.001883. Which gene interacts with this up... | PRKN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00725","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a spec... | |
medium_hidden_intermediate_00726 | Two genes are structurally linked to Enterovirus A via a downregulation relationship and to neutrophils via an enrichment relationship. One of these genes exhibits a log2 fold change of -1.501 and an adjusted p-value of 0.003717 in rhabdomyosarcoma cells (study GSE103308). Which disease is associated with this specific... | childhood onset asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via a downregulation relationship and to neutrophils via an enrichment re... | |
medium_hidden_intermediate_00727 | Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.766 and an adjusted p-value of 0.004576. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00727","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate de... | |
medium_hidden_intermediate_00728 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with DYNLL1. One of these genes exhibits a log2 fold change of -1.516 and an adjusted p-value of 0.005163 in a specific study. Which protein is encoded by this gene? | Zinc finger protein 608 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00728","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with DYNLL1. One of these ... | |
medium_hidden_intermediate_00729 | Human immunodeficiency virus 1 upregulates a gene that enables DNA-binding transcription factor activity. In a study of macrophages (GSE108897), one such gene exhibits a log2 fold change of 2.531 and an adjusted p-value of 0.01648. Which protein is encoded by this gene? | Forkhead box protein F2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00729","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables DNA-binding transcription factor activity. In a study of macr... | |
medium_hidden_intermediate_00730 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for prostate cancer. This specific gene exhibits a log2 fold change of approximately 1.53 and an adjusted p-value of approximately 0.0039. Which protein is encoded by this gene? | Sestrin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00730","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_00731 | Hepacivirus C upregulates a gene that encodes a protein binding to NEDD8. One such gene exhibits a log2 fold change of 1.550 and an adjusted p-value of 7.476e-09. Which protein is encoded by this gene? | F-box and leucine-rich repeat protein 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that encodes a protein binding to NEDD8. One such gene exhibits a log2 fold change of 1.550... | |
medium_hidden_intermediate_00732 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which is located in a protein-containing complex. This gene exhibits a log2 fold change of -3.493 and an adjusted p-value of 0.01271. Which biological process is this gene involved in? | regulation of protein stability | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which is located in a p... | |
medium_hidden_intermediate_00733 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate certain genes that are located in the sperm flagellum. One such gene exhibited a log2 fold change of 2.784 and an adjusted p-value of 0.007491. Which protein is encoded by this specific gene... | Cilia- and flagella-associated protein 70 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00733","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_00734 | Zika virus downregulates a gene that participates in translation. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -2.241 and an adjusted p-value of 0.004702. Which protein is encoded by this specific gene? | Phenylalanine--tRNA ligase alpha subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in translation. In a study of glioma stem cells (GSE114907), one such gene... | |
medium_hidden_intermediate_00735 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Calmodulin induced events. Evidence for this gene reports a log2 fold change of 1.143 and an adjusted p-value of 0.01172. Which protein is encoded by this gene? | Adenylate cyclase type 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Calmodulin induced events... | |
medium_hidden_intermediate_00739 | A gene is downregulated by Hepacivirus C and enriched in Regulatory T (Treg) cells. Evidence for this gene reports a log2 fold change of approximately -1.16 and an adjusted p-value of 0.0045. Which cellular component is this gene located in? | endoplasmic reticulum membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00739","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Hepacivirus C and enriched in Regulatory T (Treg) cells. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_00740 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with AIFM1. This gene exhibited a log2 fold change of approximately 1.85 and an adjusted p-value of approximately 2.30e-08. To which cellular component is this gene loca... | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_00741 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in DNA replication. One such gene exhibited a log2 fold change of 1.068 and an adjusted p-value of 1.469e-06. Which protein is encoded by this specific gene? | 26S proteasome regulatory subunit 6A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00741","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_00742 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables microtubule binding. Transcriptomic data for this gene reports a log2 fold change of approximately 1.046 and an adjusted p-value of 0.02506. Which protein is encoded by this gene? | WD repeat-containing protein 90 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00742","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables microtubule binding. Transcriptom... | |
medium_hidden_intermediate_00746 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables ubiquitin-protein transferase activity. One such gene exhibited a log2 fold change of approximately 1.05 and an adjusted p-value of 0.00035. Which cellular component is this specific gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables ubiqui... | |
medium_hidden_intermediate_00747 | Human immunodeficiency virus 1 upregulates a gene that is involved in the adenylate cyclase-activating G protein-coupled receptor signaling pathway. Evidence for this gene reports a log2 fold change of 1.128 and an adjusted p-value of 0.01176. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00747","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the adenylate cyclase-activating G protein-coupled rec... | |
medium_hidden_intermediate_00748 | COG8 interacts with a protein that possesses protein binding activity. Evidence identifies this specific protein as a key small GTPase that recruits the HOPS complex onto autophagic vesicles. Which protein is encoded by the gene corresponding to this entity? | Ras-related protein Rab-39A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COG8 interacts with a protein that possesses protein binding activity. Evidence identifies this specific protein as a key sm... | |
medium_hidden_intermediate_00750 | Human betaherpesvirus 5 downregulates a specific gene that participates in the Immune System. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) reports a log2 fold change of approximately -1.64 and an adjusted p-value of 0.0494. Which disease is causally linked to this gene? | hyperplasia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a specific gene that participates in the Immune System. Experimental data for this gen... | |
medium_hidden_intermediate_00751 | Two genes are structurally linked to Pegivirus C via a downregulation relationship and to vesicles via a location relationship. One of these genes exhibits a log2 fold change of approximately -2.18 and an adjusted p-value of approximately 0.00034 in peripheral blood mononuclear cells from study GSE131504. Which disease... | Ziegler-Huang syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a downregulation relationship and to vesicles via a location relationsh... | |
medium_hidden_intermediate_00754 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma. One of these genes exhibits a log2 fold change of -1.133 and an adjusted p-value of 0.01894 in a specific study. Which protein is encoded by this gene? | Epidermal growth factor-like protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00754","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma... | |
medium_hidden_intermediate_00755 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable phospholipid binding. One such gene exhibited a log2 fold change of approximately 4.71 and an adjusted p-value of approximately 1.40e-06. Which protein interacts with this specific up... | SQSTM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_00756 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated by the virus and its product interacts with CBL. Evidence for this gene reports a log2 fold change of 1.426 and an adjusted p-value of 0.04152. Which protein is encoded by this gene? | Src-like-adapter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated by the virus and its pr... | |
medium_hidden_intermediate_00758 | Zika virus downregulates a specific gene that participates in the Unfolded Protein Response (UPR). In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.081 and an adjusted p-value of 0.02859. Which disease is associated with this gene as a biomarker? | narcolepsy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the Unfolded Protein Response (UPR). In a study of glioma stem... | |
medium_hidden_intermediate_00760 | In a study of Influenza A virus infection, a specific gene is upregulated and its expression is enriched in memory B cells. Evidence for this gene reports a log2 fold change of 1.348 and an adjusted p-value of 5.303e-05. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00760","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and its expression is enriched in memory B cells. ... | |
medium_hidden_intermediate_00761 | Hepacivirus C is reported to downregulate a gene that participates in the Immune System. One such gene exhibits a log2 fold change of -1.695 and an adjusted p-value of 0.03748 in a specific study. Which protein is encoded by this gene? | Bis(5'-adenosyl)-triphosphatase ENPP4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00761","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in the Immune System. One such gene exhibits a log2 fold ... | |
medium_hidden_intermediate_00762 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in phospholipid metabolism. One such gene exhibited a log2 fold change of approximately 1.006 and an adjusted p-value of 0.0003284. What molecular function is enabled by this specific gene? | L-serine-phosphatidylethanolamine phosphatidyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes invo... | |
medium_hidden_intermediate_00764 | EP300 interacts with a specific protein that possesses protein binding activity. Evidence indicates that Cabin1 competes with p300 for binding to this protein, which is identified as MEF2. What cellular component is this protein located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00764","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EP300 interacts with a specific protein that possesses protein binding activity. Evidence indicates that Cabin1 competes wit... | |
medium_hidden_intermediate_00766 | Enterovirus A upregulates a gene that is involved in protein K48-linked deubiquitination. In a study of rhabdomyosarcoma cells (GSE103308), one such gene showed a log2 fold change of approximately 1.37 and an adjusted p-value of approximately 0.0031. Which protein is encoded by this specific gene? | OTU domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is involved in protein K48-linked deubiquitination. In a study of rhabdomyosarcoma cel... | |
medium_hidden_intermediate_00771 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in cellular responses to stimuli. Experimental data for this gene in bronchial epithelial cells from study GSE147507 show a log2 fold change of -1.121 and an adjusted p-value of 0.0003554. Which protein is encoded ... | Metallothionein-1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in cellular respon... | |
medium_hidden_intermediate_00774 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene that subsequently interacts with CEP63. This gene exhibits a log2 fold change of approximately 1.003 and an adjusted p-value of 0.002582. Which biological process is this gene involved in? | regulation of cilium assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00774","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene that subsequently interacts with... | |
medium_hidden_intermediate_00776 | In the study GSE164073, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in Sphingolipid metabolism was found to have a log2 fold change of approximately 1.192 and an adjusted p-value of 3.218e-05. Which gene interacts with this specific upregulated gene? | PLPP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00776","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE164073, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in Sphingol... | |
medium_hidden_intermediate_00778 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and onward to mammary neoplasms, animal via an association relationship. One of these genes is reported in a study (GSE157852) involving choroid plexus epithelium cells, with a log2 fold change ... | Chromogranin-A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via an upregulation relationshi... |
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