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medium_convergence_01651 | CXXC1 and ASH2L both interact with a shared protein. Evidence regarding this shared protein indicates that a point mutation (C375A) abolishes the interaction of Cfp1 with Setd1 histone H3-Lys4 methyltransferase complexes, thereby abating the rescue activity of the Cfp1(361-656) fragment. Which disease is associated wit... | intellectual developmental disorder with seizures and language delay | Medium | convergence | {"qa_id":"medium_convergence_01651","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CXXC1 and ASH2L both interact with a shared protein. Evidence regarding this shared protein indicates that a point mutation (C375A) abolishes the interaction... | |
medium_convergence_01652 | H2AX and BRCA1 both interact with a specific protein. Evidence indicates that this protein and SMURF2 act as a stabilizer and destabilizer of H2AX, respectively, through their dynamic interactions with H2AX. Which disease is associated with this protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_01652","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and BRCA1 both interact with a specific protein. Evidence indicates that this protein and SMURF2 act as a stabilizer and destabilizer of H2AX, respectiv... | |
medium_convergence_01653 | MECP2 and NCOR1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that it binds the N-CoR corepressor and is required for N-CoR-mediated repression by antagonist-bound estrogen receptor and the homeodomain protein Rpx, as well as for N-CoR suppression of... | Histone deacetylase complex subunit SAP30 | Medium | convergence | {"qa_id":"medium_convergence_01653","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECP2 and NCOR1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that it binds the N-CoR c... | |
medium_convergence_01654 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of -3.991 and an adjusted p-value of 0.01042. Which protein is encoded by this gene? | Amphoterin-induced protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01654","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibite... | |
medium_convergence_01656 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.16 and an adjusted p-value of approximately 0.0034. Which protein is encoded by this gene? | Collagen alpha-1(XII) chain | Medium | convergence | {"qa_id":"medium_convergence_01656","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (st... | |
medium_convergence_01657 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of 2.238 and an adjusted p-value of 0.005848. Which disease is associated with this gene? | diabetic retinopathy | Medium | convergence | {"qa_id":"medium_convergence_01657","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_01658 | CTNNA1 and CDC42 both interact with a specific protein. Evidence indicates that this protein forms a complex with Cdc42-GTP, a human homologue of the multi-PDZ protein PAR-3, and the regulatory domains of atypical protein kinase C (PKC) proteins. Which protein is encoded by the gene corresponding to this interacting pa... | Partitioning defective 6 homolog alpha | Medium | convergence | {"qa_id":"medium_convergence_01658","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNA1 and CDC42 both interact with a specific protein. Evidence indicates that this protein forms a complex with Cdc42-GTP, a human homologue of the multi-P... | |
medium_convergence_01659 | CHMP2A and TSG101 both interact with a shared protein. Evidence indicates that this shared protein is a component of a complex containing a fraction of total cellular TSG101 and VPS37A, but explicitly excluding VPS37C. Which disease is associated with this shared protein? | spastic paraplegia 80, autosomal dominant | Medium | convergence | {"qa_id":"medium_convergence_01659","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP2A and TSG101 both interact with a shared protein. Evidence indicates that this shared protein is a component of a complex containing a fraction of total... | |
medium_convergence_01660 | FANCA and BLM both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which gene does this shared protein interact with? | GINS2 | Medium | convergence | {"qa_id":"medium_convergence_01660","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and BLM both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction with F... | |
medium_convergence_01661 | The basolateral amygdaloid nuclear complex and the corticomedial nuclear complex are both classified as types of a specific anatomical structure. Evidence regarding the basolateral amygdaloid nuclear complex describes it as a set of amygdalar nuclei comprising the lateral nucleus (LA), the basal nucleus (BA), and the a... | gray matter | Medium | convergence | {"qa_id":"medium_convergence_01661","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The basolateral amygdaloid nuclear complex and the corticomedial nuclear complex are both classified as types of a specific anatomical structure. Evidence re... | |
medium_convergence_01662 | RIG-I and CASP10 share multiple binding partners. One such partner is identified in the literature as REUL, a RING-finger protein that specifically interacts with RIG-I. Which cell type is this specific partner enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_01662","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIG-I and CASP10 share multiple binding partners. One such partner is identified in the literature as REUL, a RING-finger protein that specifically interacts... | |
medium_convergence_01663 | Both Influenza A virus and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in bronchial epithelial cells shows a log2 fold change of approximately 1.145 and an adjusted p-value of 0.0003454. Which protein is encoded by this gene? | Transmembrane protein 171 | Medium | convergence | {"qa_id":"medium_convergence_01663","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in bronchial epithelial cel... | |
medium_convergence_01664 | Methotrexate and Clofarabine both interact with a specific shared drug. Evidence indicates that the phosphorylation of 3TC was significantly increased in the presence of hydroxyurea, this shared drug (referred to as MTX in the context), or fludarabine. Which disease is this shared drug indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_01664","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Methotrexate and Clofarabine both interact with a specific shared drug. Evidence indicates that the phosphorylation of 3TC was significantly increased in the... | |
medium_convergence_01665 | HIST1H4A and BABAM2 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that MERIT40 is assembled into a complex containing a specific DNA damage response protein and CCDC98 via its direct interaction with BRE/BRCC45. Which disease is associated with that specific s... | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01665","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST1H4A and BABAM2 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that MERIT40 is assembled into ... | |
medium_convergence_01666 | AKAP9 and B9D1 both interact with a shared protein partner. Evidence regarding this partner indicates that the CM2-like motif is essential for the association of the centrosome-targeting domain to pericentrin and AKAP450. Which cell type is this shared protein partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01666","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and B9D1 both interact with a shared protein partner. Evidence regarding this partner indicates that the CM2-like motif is essential for the associatio... | |
medium_convergence_01667 | Both ASF1A and HIRA interact with a common protein partner. Evidence regarding this partner states: 'We recently reported that a short N-terminal fragment of this protein containing amino acids 1-175 is necessary and sufficient for interaction with the WD repeats of HIRA and attributed this interaction to a region from... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01667","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ASF1A and HIRA interact with a common protein partner. Evidence regarding this partner states: 'We recently reported that a short N-terminal fragment of... | |
medium_convergence_01668 | ACTR3 and ARPC1A share a common binding partner. Evidence for this partner indicates that its NTA region interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which disease is associated with this shared partner ... | esophageal squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01668","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and ARPC1A share a common binding partner. Evidence for this partner indicates that its NTA region interacts directly with the Arp2/3 complex, as demon... | |
medium_convergence_01669 | ESR1 and HDAC10 share multiple binding partners. One such partner is implicated in evidence stating: 'In vivo and in vitro binding assays revealed that whereas 4-hydroxytamoxifen (OHT) induced binding of ERalpha to both an AF-1 coactivator complex (p68/p72 and p300) and corepressor complexes (a corepressor protein/SMRT... | Nuclear receptor corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_01669","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC10 share multiple binding partners. One such partner is implicated in evidence stating: 'In vivo and in vitro binding assays revealed that where... | |
medium_convergence_01671 | Both Human alphaherpesvirus 3 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of -1.034 and an adjusted p-value of 0.001768. Which disease is associated with this gene as a biomarker? | non-small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01671","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line ... | |
medium_convergence_01672 | DPP4 and DSP both interact with a specific shared protein. Experimental evidence confirms that the DP COOH terminus (DPCT) interacts with at least two regions of the head domain of the type II epidermal keratin K1. Which protein is encoded by this shared entity? | Keratin, type II cytoskeletal 1 | Medium | convergence | {"qa_id":"medium_convergence_01672","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DPP4 and DSP both interact with a specific shared protein. Experimental evidence confirms that the DP COOH terminus (DPCT) interacts with at least two region... | |
medium_convergence_01673 | CTNNB1 and PTK2B share multiple interacting partners. One such shared partner is identified in the statement: 'Herein, we report that a specific protein interacts with the oncoprotein β-catenin.' Which protein is encoded by this shared interacting partner? | RB1-inducible coiled-coil protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01673","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and PTK2B share multiple interacting partners. One such shared partner is identified in the statement: 'Herein, we report that a specific protein inte... | |
medium_convergence_01674 | YWHAQ and PARP1 both interact with a specific shared protein. Evidence indicates that 14-3-3 tau interacts with this protein when it is phosphorylated by ATM during DNA damage, thereby inhibiting its ubiquitination. Which protein is encoded by the gene corresponding to this shared entity? | Transcription factor E2F1 | Medium | convergence | {"qa_id":"medium_convergence_01674","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and PARP1 both interact with a specific shared protein. Evidence indicates that 14-3-3 tau interacts with this protein when it is phosphorylated by ATM... | |
medium_convergence_01675 | CTCF and ASH2L both interact with a specific shared protein. Evidence regarding this entity states: 'Here we show that a minimized human RBBP5-ASH2L heterodimer is the structural unit that interacts with and activates all MLL family histone methyltransferases.' Which protein is encoded by this shared entity? | Histone-lysine N-methyltransferase 2D | Medium | convergence | {"qa_id":"medium_convergence_01675","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTCF and ASH2L both interact with a specific shared protein. Evidence regarding this entity states: 'Here we show that a minimized human RBBP5-ASH2L heterodi... | |
medium_convergence_01676 | CRY1 and CSNK1E each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that CRY1 or CRY2 (or both) showed light-independent interactions with CLOCK and BMAL1, as well as with this shared protein, PER2, and TIM. Which protein is encoded by the gene corresponding to that... | Period circadian protein homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_01676","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY1 and CSNK1E each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that CRY1 or CRY2 (or both) showed ... | |
medium_convergence_01677 | PRKN and AMBRA1 share multiple interacting partners. One such partner is described in the evidence: 'We have identified the 20S proteasomal subunit alpha4 (synonyms: PSMA7, XAPC7, subunit alpha type 7) as a new interacting partner of parkin.' Which protein is encoded by the gene corresponding to this specific interacti... | Proteasome subunit alpha type-4 | Medium | convergence | {"qa_id":"medium_convergence_01677","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and AMBRA1 share multiple interacting partners. One such partner is described in the evidence: 'We have identified the 20S proteasomal subunit alpha4 (s... | |
medium_convergence_01678 | COG5 and COPG1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Yeast two-hybrid analysis indicates that gamma1- and gamma2-COPs can directly, albeit promiscuously, interact with zeta1- and zeta2-COPs.' Which protein is encoded by the gene corresponding ... | Coatomer subunit zeta-2 | Medium | convergence | {"qa_id":"medium_convergence_01678","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COG5 and COPG1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Yeast two-hybrid analysis i... | |
medium_convergence_01679 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately 1.393 and an adjusted p-value of 0.002287. In which cell type is this gene reported to be enriched? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01679","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of a... | |
medium_convergence_01680 | RUVBL2 and SMG1 both interact with a shared protein. Experimental evidence indicates that this protein binds to the HEAT repeat segments of ATM and mTOR, as observed in in vivo and in vitro studies involving PIKK family members. Which disease is associated with this shared protein? | TELO2-related intellectual disability-neurodevelopmental disorder | Medium | convergence | {"qa_id":"medium_convergence_01680","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and SMG1 both interact with a shared protein. Experimental evidence indicates that this protein binds to the HEAT repeat segments of ATM and mTOR, as ... | |
medium_convergence_01681 | EP400 and EPC1 both interact with a common protein partner. Experimental evidence indicates that a recombinant trimeric complex consisting of Tip60, EPC1, and this shared partner is sufficient to reconstitute robust nucleosomal histone acetyltransferase (HAT) activity in vitro, analogous to yeast systems. Which protein... | Inhibitor of growth protein 3 | Medium | convergence | {"qa_id":"medium_convergence_01681","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP400 and EPC1 both interact with a common protein partner. Experimental evidence indicates that a recombinant trimeric complex consisting of Tip60, EPC1, an... | |
medium_convergence_01682 | AP1M2 and AP1G1 both interact with multiple shared partners. One such shared partner is described in evidence stating: 'Analysis using a yeast two-hybrid system has revealed that, similarly to gamma1-adaptin, gamma2-adaptin is capable of interacting not only with the sigma1 chain (called as [REDACTED] in this paper), t... | MEDNIK syndrome | Medium | convergence | {"qa_id":"medium_convergence_01682","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP1M2 and AP1G1 both interact with multiple shared partners. One such shared partner is described in evidence stating: 'Analysis using a yeast two-hybrid sys... | |
medium_convergence_01683 | STIP1 and ARHGDIA both interact with a shared protein. Evidence indicates that this shared protein is involved in a mechanism where Rho GDI directly interacts with ERM, initiating the activation of Rho subfamily members by reducing Rho GDI activity. Which protein is encoded by this shared entity? | Radixin | Medium | convergence | {"qa_id":"medium_convergence_01683","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STIP1 and ARHGDIA both interact with a shared protein. Evidence indicates that this shared protein is involved in a mechanism where Rho GDI directly interact... | |
medium_convergence_01684 | Both Measles morbillivirus and Rift Valley fever phlebovirus are associated with the upregulation of a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.577 and an adjusted p-value of 0.001062. Which protein is encoded by this gene? | 5'-3' exoribonuclease 1 | Medium | convergence | {"qa_id":"medium_convergence_01684","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are associated with the upregulation of a specific gene. Experimental data for this gene reports... | |
medium_convergence_01685 | FADD and IKBKE both interact with a shared protein. Evidence regarding this shared protein states: 'Here we show that the shared protein directly interacts with TRAF2 and FADD, signal transducers that activate NF-kappa B and induce apoptosis, respectively.' Which protein is encoded by this shared entity? | Tumor necrosis factor receptor type 1-associated DEATH domain protein | Medium | convergence | {"qa_id":"medium_convergence_01685","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FADD and IKBKE both interact with a shared protein. Evidence regarding this shared protein states: 'Here we show that the shared protein directly interacts w... | |
medium_convergence_01686 | CHEK1 and BLM both interact with a shared protein. Evidence indicates that this shared protein localizes to the nucleus and associates with Chk1 specifically following replication stress or other types of DNA damage. Which protein is encoded by the gene corresponding to this shared entity? | Claspin | Medium | convergence | {"qa_id":"medium_convergence_01686","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and BLM both interact with a shared protein. Evidence indicates that this shared protein localizes to the nucleus and associates with Chk1 specifically... | |
medium_convergence_01687 | Both Human polyomavirus 1 and Measles morbillivirus are known to upregulate a specific host gene. Experimental data from renal epithelial cells (study GSE135833) indicate that this gene exhibits a log2 fold change of approximately 1.258 and an adjusted p-value of 0.004176. Which biological process is this gene involved... | protein dephosphorylation | Medium | convergence | {"qa_id":"medium_convergence_01687","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Measles morbillivirus are known to upregulate a specific host gene. Experimental data from renal epithelial cells (study GSE135... | |
medium_convergence_01689 | Both RPGRIP1L and RPGRIP1 interact with a common protein partner. Evidence for one such partner states: 'We identified several alternatively spliced gene products, some with retina-restricted expression, that interact specifically with this protein in vivo and in vitro.' Which protein is encoded by this specific intera... | X-linked retinitis pigmentosa GTPase regulator | Medium | convergence | {"qa_id":"medium_convergence_01689","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both RPGRIP1L and RPGRIP1 interact with a common protein partner. Evidence for one such partner states: 'We identified several alternatively spliced gene pro... | |
medium_convergence_01690 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.356 and an adjusted p-value of 0.03658. Which protein does this upregulated gene ... | SND1 | Medium | convergence | {"qa_id":"medium_convergence_01690","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T... | |
medium_convergence_01691 | EP300 and ASH2L both interact with a specific protein. Evidence indicates that a minimized human RBBP5-ASH2L heterodimer serves as the structural unit interacting with and activating all MLL family histone methyltransferases. Which protein, connected to this shared entity via an 'encodes' relationship, is the best fit ... | Histone-lysine N-methyltransferase 2C | Medium | convergence | {"qa_id":"medium_convergence_01691","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ASH2L both interact with a specific protein. Evidence indicates that a minimized human RBBP5-ASH2L heterodimer serves as the structural unit intera... | |
medium_convergence_01692 | ESR1 and SREBF1 both interact with a shared protein. Evidence regarding this shared protein states: 'We present evidence that DRIP205 interacts with another member of the steroid receptor subfamily, estrogen receptor (ER).' Which protein product is encoded by this shared entity? | Mediator of RNA polymerase II transcription subunit 14 | Medium | convergence | {"qa_id":"medium_convergence_01692","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and SREBF1 both interact with a shared protein. Evidence regarding this shared protein states: 'We present evidence that DRIP205 interacts with another ... | |
medium_convergence_01694 | CTBP1 and RING1 both interact with a shared protein. Evidence indicates that this shared protein interacts with the CtBP corepressor through a CtBP-interacting motif in its amino terminus. Which protein is encoded by this shared entity? | BCL-6 corepressor-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01694","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and RING1 both interact with a shared protein. Evidence indicates that this shared protein interacts with the CtBP corepressor through a CtBP-interacti... | |
medium_convergence_01695 | Serotonin secretion by mast cells and serotonin secretion by basophils share multiple upstream biological processes. One such shared process is characterized by the regulated release of serotonin by a mast cell or group of mast cells. Which broader biological process is this shared entity a part of? | exocytosis | Medium | convergence | {"qa_id":"medium_convergence_01695","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Serotonin secretion by mast cells and serotonin secretion by basophils share multiple upstream biological processes. One such shared process is characterized... | |
medium_convergence_01696 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cells (GSE11238), this gene exhibited a log2 fold change of approximately -1.124 and an adjusted p-value of 0.02044. Which protein is encoded by this gene? | Terminal uridylyltransferase 4 | Medium | convergence | {"qa_id":"medium_convergence_01696","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cells (GSE11238), this gene exhibited a l... | |
medium_convergence_01697 | IGF1 and IGF2 both interact with a specific protein. Experimental evidence indicates that substituting residues 48-50 of IGF with the analogous residues from human insulin (Thr-Ser-Ile) reduces binding to this protein by 15-50-fold, while reducing binding to IGFBP-1, -5, and -6 by more than 50-fold. Which gene encodes ... | Insulin-like growth factor-binding protein 4 | Medium | convergence | {"qa_id":"medium_convergence_01697","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IGF1 and IGF2 both interact with a specific protein. Experimental evidence indicates that substituting residues 48-50 of IGF with the analogous residues from... | |
medium_convergence_01698 | CREBBP and NCOA6 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'The helix 3 and helix 12 mutations strikingly reduced the ability of this protein to interact with the coactivators steroid receptor coactivator-1, ACTR, and the CREB-binding protein.' Which protein is e... | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_01698","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and NCOA6 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'The helix 3 and helix 12 mutations strik... | |
medium_convergence_01699 | KHDRBS1 and CTNND1 share multiple interacting partners. One such shared partner is a Src family kinase that, like Fyn, associates with Sam68 via its Src homology 2 and 3 domains. Which disease is linked to this specific kinase through a biomarker relationship? | familial glucocorticoid deficiency | Medium | convergence | {"qa_id":"medium_convergence_01699","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and CTNND1 share multiple interacting partners. One such shared partner is a Src family kinase that, like Fyn, associates with Sam68 via its Src homo... | |
medium_convergence_01700 | Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are known to downregulate the expression of a specific gene. Experimental data for this gene in gamma delta T-lymphocytes reports a log2 fold change of -2.542 and an adjusted p-value of 0.02411. In which cell type is this gene repor... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01700","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are known to downregulate the expression of a specific gene. Experime... | |
medium_convergence_01701 | ARF1 and ARF6 both interact with a specific protein. Evidence regarding this protein indicates that its GAT region targets reporter proteins to the Golgi complex, induces the dissociation of ARF-regulated coats (such as AP-1, AP-3, AP-4, and COPI) from membranes upon overexpression, and interacts with activated ARF1. W... | ADP-ribosylation factor-binding protein GGA3 | Medium | convergence | {"qa_id":"medium_convergence_01701","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARF1 and ARF6 both interact with a specific protein. Evidence regarding this protein indicates that its GAT region targets reporter proteins to the Golgi com... | |
medium_convergence_01702 | AKT2 and HSP90AA1 both interact with a specific shared protein. Experimental evidence indicates that this shared protein preferentially binds to AKT2 to facilitate its activation, as demonstrated by pulldown assays using His-tagged recombinant protein and MCF-7 cell lysates. Which protein is encoded by the gene corresp... | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Medium | convergence | {"qa_id":"medium_convergence_01702","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT2 and HSP90AA1 both interact with a specific shared protein. Experimental evidence indicates that this shared protein preferentially binds to AKT2 to faci... | |
medium_convergence_01703 | Both Human alphaherpesvirus 3 and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.054 and an adjusted p-value of 5.953e-05. Which protein is encoded by this ... | Homer protein homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_01703","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (st... | |
medium_convergence_01704 | Flag B amacrine cells and fountain amacrine cells share synaptic input/output regions. One such shared region is associated with a flag amacrine cell subtype that releases glycine and has post-synaptic terminals in sublaminar layers S3, S4, and S5. Which specific sublaminar layer, connected to this entity via a 'part o... | sublaminar layers S2 or S3 | Medium | convergence | {"qa_id":"medium_convergence_01704","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Flag B amacrine cells and fountain amacrine cells share synaptic input/output regions. One such shared region is associated with a flag amacrine cell subtype... | |
medium_convergence_01705 | MIR130A and MIR21 are both involved in more than one shared biological process. Evidence indicates that miR-130 enhances hypoxia-induced smooth muscle proliferation. Which biological process, shared by both MIR130A and MIR21, is connected to the entity described in this evidence through the relation 'positively regulat... | vascular associated smooth muscle cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_01705","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR130A and MIR21 are both involved in more than one shared biological process. Evidence indicates that miR-130 enhances hypoxia-induced smooth muscle prolif... | |
medium_convergence_01706 | Both CSF2RB and DMBT1 interact with a common protein partner. Evidence regarding this partner states: 'We have shown that soluble gp-340 binds a pulmonary surfactant protein in a calcium-dependent manner independent of the lectin activity of that protein.' Which protein is encoded by this shared partner? | Pulmonary surfactant-associated protein A1 | Medium | convergence | {"qa_id":"medium_convergence_01706","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CSF2RB and DMBT1 interact with a common protein partner. Evidence regarding this partner states: 'We have shown that soluble gp-340 binds a pulmonary su... | |
medium_convergence_01707 | CEBPB and MYC share a common interacting partner. Experimental evidence involving immunoprecipitation-immunoblotting, chromatin immunoprecipitation, and GST pull-down assays indicates that this partner, identified as the silencing mediator for retinoid and thyroid hormone receptors, binds to the TAD domain of C/EBPbeta... | polyarticular arthritis | Medium | convergence | {"qa_id":"medium_convergence_01707","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and MYC share a common interacting partner. Experimental evidence involving immunoprecipitation-immunoblotting, chromatin immunoprecipitation, and GST ... | |
medium_convergence_01708 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of 2.620 and an adjusted p-value of 0.003694. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01708","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of 2... | |
medium_convergence_01710 | EP300 and HIST2H3A share multiple binding partners. One shared partner is described in evidence stating: 'This enhancement was due to direct protein-protein interactions of both pax-6 and cdx-2 with the N-terminal C/H1 domain of p300.' Which protein is connected to this shared partner through the 'encodes' relationship... | Paired box protein Pax-6 | Medium | convergence | {"qa_id":"medium_convergence_01710","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HIST2H3A share multiple binding partners. One shared partner is described in evidence stating: 'This enhancement was due to direct protein-protein ... | |
medium_convergence_01711 | EMD and BAG6 both interact with a shared protein. Evidence regarding this shared entity states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as novel interaction partners while interaction with Hsc70 was confirmed.' Which disease is associated with this shared protein? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_01711","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EMD and BAG6 both interact with a shared protein. Evidence regarding this shared entity states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as nov... | |
medium_convergence_01714 | Toremifene and Tamoxifen share a common drug interaction partner. Evidence indicates that this shared partner, identified as a PDE5 inhibitor, acts synergistically with an SERM to inhibit myofibroblast transformation, collagen gel contraction, and extracellular matrix production. Which disease is this shared drug indic... | erectile dysfunction | Medium | convergence | {"qa_id":"medium_convergence_01714","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Toremifene and Tamoxifen share a common drug interaction partner. Evidence indicates that this shared partner, identified as a PDE5 inhibitor, acts synergist... | |
medium_convergence_01716 | MIR920 and MIR98 are both involved in more than one shared biological process. One piece of evidence states: 'Overexpression of miR-488 and miR-920 could significantly inhibit the gene and protein expression of IL-8 and TNF-α in MSU-induced THP-1 cells.' Which biological process, shared by MIR920 and MIR98, is connecte... | interleukin-8 production | Medium | convergence | {"qa_id":"medium_convergence_01716","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR920 and MIR98 are both involved in more than one shared biological process. One piece of evidence states: 'Overexpression of miR-488 and miR-920 could sig... | |
medium_convergence_01717 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.38 and an adjusted p-value of approximately 7.21e-09. Which protein is encoded by this gene? | Transmembrane protein 102 | Medium | convergence | {"qa_id":"medium_convergence_01717","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_01718 | CTNNB1 and SMARCA4 share multiple interacting partners. One such shared partner is implicated in a study demonstrating that cyclin-dependent kinase 2 (CDK2), in association with cyclin A or cyclin E, directly binds to beta-catenin. Which protein is encoded by this shared interacting partner? | G1/S-specific cyclin-E1 | Medium | convergence | {"qa_id":"medium_convergence_01718","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and SMARCA4 share multiple interacting partners. One such shared partner is implicated in a study demonstrating that cyclin-dependent kinase 2 (CDK2),... | |
medium_convergence_01719 | MARK2 and LATS2 share multiple interacting partners. One such shared partner is implicated in a mechanism where clustering of the CD44 extracellular domain by high-molecular-weight hyaluronan recruits the polarity-regulating kinase PAR1b, leading to the disruption of the Hippo signaling-inhibitory PAR1b-MST complex. Wh... | neuroblastoma | Medium | convergence | {"qa_id":"medium_convergence_01719","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MARK2 and LATS2 share multiple interacting partners. One such shared partner is implicated in a mechanism where clustering of the CD44 extracellular domain b... | |
medium_convergence_01720 | Vaccinia virus and Enterovirus A both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of -3.089 and an adjusted p-value of 0.01183. Which protein is encoded by this gene? | DCC-interacting protein 13-beta | Medium | convergence | {"qa_id":"medium_convergence_01720","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a lo... | |
medium_convergence_01721 | OPTN and BIRC3 share multiple binding partners. One shared partner is described in evidence stating that Optineurin competitively antagonizes NEMO's binding to polyubiquitinated RIPK1 and that its overexpression inhibits TNFalpha-induced NF-kappaB activation. Which protein is connected to this specific shared entity th... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_01721","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and BIRC3 share multiple binding partners. One shared partner is described in evidence stating that Optineurin competitively antagonizes NEMO's binding ... | |
medium_convergence_01723 | ARPC1A and AP2B1 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'A highly conserved 20-amino acid sequence in the C-terminal region of a low-density lipoprotein receptor-related protein bound the beta(2)-adaptin subunit of AP-2.' Which disease is connected to that entity th... | plasma cell neoplasm | Medium | convergence | {"qa_id":"medium_convergence_01723","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC1A and AP2B1 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'A highly conserved 20-amino acid sequence in t... | |
medium_convergence_01724 | HRAS and NCK1 share a common interacting partner. Evidence for this partner states: 'Similar to Nck interacting kinase (NIK) and Traf2 and Nck-interacting kinase (TNIK), hMINK beta moderately activates c-Jun N-terminal kinase (JNK) and associates with Nck via the intermediate domain in the yeast two-hybrid system and i... | Misshapen-like kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_01724","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and NCK1 share a common interacting partner. Evidence for this partner states: 'Similar to Nck interacting kinase (NIK) and Traf2 and Nck-interacting ki... | |
medium_convergence_01725 | DYRK1A and RELA each interact with more than one shared gene product. Evidence concerning one shared entity reports that a histone methyltransferase interacts with this entity in the nucleus to enhance transcription of stanniocalcin-1 (STC1) and to facilitate cancer metastasis. Which protein is encoded by that entity? | Histone-lysine N-methyltransferase 2D | Medium | convergence | {"qa_id":"medium_convergence_01725","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYRK1A and RELA each interact with more than one shared gene product. Evidence concerning one shared entity reports that a histone methyltransferase interact... | |
medium_convergence_01726 | Measles morbillivirus and Pegivirus C both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.215 and an adjusted p-value of 0.0188. Which protein does this gene product interact with? | H2BC8 | Medium | convergence | {"qa_id":"medium_convergence_01726","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Pegivirus C both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.215 and ... | |
medium_convergence_01727 | MTOR and MLST8 share multiple interacting partners. One such shared partner is experimentally reported to coprecipitate with and be directly phosphorylated by MTOR. Which protein encodes this specific shared partner? | Pleckstrin homology domain-containing family M member 1 | Medium | convergence | {"qa_id":"medium_convergence_01727","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and MLST8 share multiple interacting partners. One such shared partner is experimentally reported to coprecipitate with and be directly phosphorylated b... | |
medium_convergence_01728 | MCM2 and MCM5 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we show that human [the protein encoded by the shared partner gene] is capable of interacting with individual MCM proteins 2 through 7 when co-expressed in insect cells and can greatly increa... | Mini-chromosome maintenance complex-binding protein | Medium | convergence | {"qa_id":"medium_convergence_01728","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM2 and MCM5 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we show that human [the prot... | |
medium_convergence_01729 | EP300 and MYC both interact with a shared protein partner. Experimental evidence indicates that this partner and MYC associate with distinct domains of KDM5B, and that the C-terminal 270 amino acids of this partner are required for its interaction with KDM5B. Which protein product is encoded by this shared partner? | Transcription factor AP-2 gamma | Medium | convergence | {"qa_id":"medium_convergence_01729","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MYC both interact with a shared protein partner. Experimental evidence indicates that this partner and MYC associate with distinct domains of KDM5B... | |
medium_convergence_01730 | ANAPC13 and ANAPC11 both interact with a common protein partner. Evidence indicates that this partner is a cullin-related protein, as both APC11 and UbcH10 bind to the C-terminal cullin homology domain of this partner, whereas Ubc4 interacts with APC11 directly. Which disease is associated with this shared partner via ... | colitis | Medium | convergence | {"qa_id":"medium_convergence_01730","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC13 and ANAPC11 both interact with a common protein partner. Evidence indicates that this partner is a cullin-related protein, as both APC11 and UbcH10 b... | |
medium_convergence_01731 | HBEGF and ERBB2 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that 8 of 10 possible homo-and heterodimeric complexes of ErbB proteins can be hierarchically induced by ligand binding.' Which protein is encoded by this shared partner? | Receptor tyrosine-protein kinase erbB-4 | Medium | convergence | {"qa_id":"medium_convergence_01731","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HBEGF and ERBB2 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that 8 of 10 possible homo-and heterodimeric co... | |
medium_convergence_01732 | STK4 and ACTN1 share a common interaction partner. Experimental evidence involving immunoprecipitation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry indicates that this shared partner forms complexes with nonmuscle alpha-actinin-1 and alpha-actinin-4, and is identified as a PDZ and LI... | PDZ and LIM domain protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01732","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STK4 and ACTN1 share a common interaction partner. Experimental evidence involving immunoprecipitation and matrix-assisted laser desorption/ionization time-o... | |
medium_convergence_01733 | FBXW7 and RAF1 share multiple interacting partners. One such partner is described in evidence stating: 'A protein interacts with Ras and Raf and is able to form a ternary complex with the two proteins.' Which disease is associated with this specific shared partner through genomic alterations? | Noonan syndrome | Medium | convergence | {"qa_id":"medium_convergence_01733","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW7 and RAF1 share multiple interacting partners. One such partner is described in evidence stating: 'A protein interacts with Ras and Raf and is able to f... | |
medium_convergence_01734 | GTF2A1 and IKBKE each interact with more than one shared transcription factor. Evidence concerning one shared entity reports: 'Furthermore, NS7a interacts simultaneously with the kinase domain (KD) and the scaffold dimerization domain (SDD) of IKKε, competing with TRAF3, and this transcription factor for binding to IKK... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01734","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2A1 and IKBKE each interact with more than one shared transcription factor. Evidence concerning one shared entity reports: 'Furthermore, NS7a interacts si... | |
medium_convergence_01735 | HSPA4 and MDM2 both interact with a specific protein. Experimental evidence indicates that Hsp70 binds to Leu-640, which is immediately preceding the conserved turn motif autophosphorylation site (Thr-641) in this protein. Which protein is encoded by the gene corresponding to this interacting entity? | Protein kinase C beta type | Medium | convergence | {"qa_id":"medium_convergence_01735","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA4 and MDM2 both interact with a specific protein. Experimental evidence indicates that Hsp70 binds to Leu-640, which is immediately preceding the conserv... | |
medium_convergence_01736 | FANCC and FAAP24 both interact with a specific protein. Evidence indicates that FANCE mediates the interaction between this protein and FANCC in a yeast three-hybrid system, and confirms this association in human cells. Which protein is encoded by the gene corresponding to this interacting partner? | Fanconi anemia group D2 protein | Medium | convergence | {"qa_id":"medium_convergence_01736","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FAAP24 both interact with a specific protein. Evidence indicates that FANCE mediates the interaction between this protein and FANCC in a yeast thre... | |
medium_convergence_01737 | ANAPC7 and AURKB share common binding partners. One such shared partner is identified as a gene encoding a protein that binds APC16 and APC7 and contains a >200-residue loop that is heavily phosphorylated during mitosis. Which gene interacts with this specific shared partner? | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_01737","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC7 and AURKB share common binding partners. One such shared partner is identified as a gene encoding a protein that binds APC16 and APC7 and contains a >... | |
medium_convergence_01738 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.02 and an adjusted p-value of 0.0029. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01738","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leuke... | |
medium_convergence_01739 | MDM2 and TP53 share multiple interacting partners. One such shared partner physically interacts with MDM2 and promotes ATM-mediated inhibitory phosphorylation of MDM2 following ionizing radiation. Which gene interacts with this specific shared partner? | SEC16A | Medium | convergence | {"qa_id":"medium_convergence_01739","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and TP53 share multiple interacting partners. One such shared partner physically interacts with MDM2 and promotes ATM-mediated inhibitory phosphorylatio... | |
medium_convergence_01741 | Pegaspargase and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozil explain the increased plasma statin concentrations and, together with pharmacodynamic factors, the increased risk of myotoxicity when coadministered with statins.' Which ... | Familial type 3 hyperlipoproteinemia | Medium | convergence | {"qa_id":"medium_convergence_01741","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozil explain... | |
medium_convergence_01742 | UBC and VCP each interact with more than one shared gene. Evidence concerning one shared entity reports: 'The PUB domain mediated robust binding to the carboxy-terminus of p97, while the UBX domain did not contribute to p97 binding.' Which gene is connected to that entity through interacts with? | CAV1 | Medium | convergence | {"qa_id":"medium_convergence_01742","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBC and VCP each interact with more than one shared gene. Evidence concerning one shared entity reports: 'The PUB domain mediated robust binding to the carbo... | |
medium_convergence_01743 | HDAC1 and MYC share a common interaction partner. Evidence regarding this shared partner states: 'We have isolated the cDNA encoding a novel c-Myc-binding protein, [REDACTED], by the yeast two-hybrid screening of a human HeLa cell cDNA library.' Which protein is encoded by this shared interaction partner? | Prefoldin subunit 5 | Medium | convergence | {"qa_id":"medium_convergence_01743","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and MYC share a common interaction partner. Evidence regarding this shared partner states: 'We have isolated the cDNA encoding a novel c-Myc-binding pr... | |
medium_convergence_01744 | BIRC5 and BUB1B both interact with a shared protein. Evidence regarding this shared protein states: 'We call this factor the mitotic checkpoint complex (MCC) as it consists of hBUBR1, hBUB3, CDC20, and MAD2 checkpoint proteins in near equal stoichiometry.' Which protein is encoded by this shared entity? | Mitotic checkpoint protein BUB3 | Medium | convergence | {"qa_id":"medium_convergence_01744","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC5 and BUB1B both interact with a shared protein. Evidence regarding this shared protein states: 'We call this factor the mitotic checkpoint complex (MCC)... | |
medium_convergence_01746 | PTGES3 and HSP90AB1 both interact with a shared protein. Evidence regarding this shared protein states: 'In this report we show that the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif (where Xaa = any amino acid) in these proteins with the N-terminal Myeloid Ne... | Egl nine homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_01746","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PTGES3 and HSP90AB1 both interact with a shared protein. Evidence regarding this shared protein states: 'In this report we show that the heat shock protein 9... | |
medium_convergence_01748 | RAD50 and CREBBP both interact with a shared protein. Experimental evidence indicates that this shared protein interacts with CBP in a ligand-independent manner, specifically involving the middle portion (amino acids 119-375) of the shared protein and two distinct regions (amino acids 271-451 and 1626-2259) of CBP. Whi... | Hepatocyte nuclear factor 4-alpha | Medium | convergence | {"qa_id":"medium_convergence_01748","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and CREBBP both interact with a shared protein. Experimental evidence indicates that this shared protein interacts with CBP in a ligand-independent man... | |
medium_convergence_01749 | Human alphaherpesvirus 1 and West Nile virus both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE100576) reports a log2 fold change of approximately 1.16 and an adjusted p-value of 0.016. Which disease is associated with this gene as a biomarker? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_01749","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and West Nile virus both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE100... | |
medium_convergence_01750 | EXTL3 and REG3A are both associated with a shared biological process. Evidence indicates that the expression of one of these entities by keratinocytes is induced by interleukin-17 (IL-17) via activation of keratinocyte-encoded IL-17 receptor A (IL-17RA). This signaling feeds back on keratinocytes to inhibit terminal di... | keratinocyte differentiation | Medium | convergence | {"qa_id":"medium_convergence_01750","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXTL3 and REG3A are both associated with a shared biological process. Evidence indicates that the expression of one of these entities by keratinocytes is ind... | |
medium_convergence_01751 | CHD4 and CBX3 both interact with a shared protein. Evidence for one such shared interaction indicates that a yeast two-hybrid assay and an in vitro binding assay demonstrated that the human LR domain binds to heterochromatin protein 1 (HP1), a well-characterized mediator of heterochromatin formation. Which protein is e... | Proliferation marker protein Ki-67 | Medium | convergence | {"qa_id":"medium_convergence_01751","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and CBX3 both interact with a shared protein. Evidence for one such shared interaction indicates that a yeast two-hybrid assay and an in vitro binding a... | |
medium_convergence_01752 | DNA2 and FIGNL1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we identified through genetic and protein-protein interaction screens FIDGETIN-LIKE-1 INTERACTING PROTEIN as a new partner of the previously characterized anti-crossover factor FIDGETIN-LIKE-1 (FIGL1) in Arab... | FIGNL1-interacting regulator of recombination and mitosis | Medium | convergence | {"qa_id":"medium_convergence_01752","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNA2 and FIGNL1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we identified through genetic and protein-pro... | |
medium_convergence_01753 | DAXX and CASP10 both interact with a specific shared protein. Experimental evidence indicates that Fluorescent resonance energy transfer analysis demonstrates that the death-effector domains of caspase-8 and caspase-10 both interact with the death-effector domain of this shared protein. Which protein is encoded by this... | FAS-associated death domain protein | Medium | convergence | {"qa_id":"medium_convergence_01753","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and CASP10 both interact with a specific shared protein. Experimental evidence indicates that Fluorescent resonance energy transfer analysis demonstrate... | |
medium_convergence_01754 | OPTN and HSPA8 share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we identified optineurin (OPTN) as an [entity]-binding protein by yeast two-hybrid screening using [entity] as bait.' Which protein is encoded by this specific interacting entity? | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_01754","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and HSPA8 share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we identified optineurin (OPTN) as an [e... | |
medium_convergence_01755 | COMMD1 and ELOC both interact with a shared protein. Evidence regarding this shared protein states: 'Like other SOCS family members, SOCS-6 binds to elongins B and C through its SOCS box, suggesting that it might act as an E3 ubiquitin ligase that targets proteins bound to its SH2 domain for ubiquitination and proteaso... | SCAMP1 | Medium | convergence | {"qa_id":"medium_convergence_01755","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and ELOC both interact with a shared protein. Evidence regarding this shared protein states: 'Like other SOCS family members, SOCS-6 binds to elongins... | |
medium_convergence_01756 | ESRRG and PPARG both interact with a shared protein. Evidence regarding this shared protein states: 'This repression correlates with a strong in vitro binding between several regions of the shared protein and the three ERR isoforms.' Which protein is encoded by the gene corresponding to this shared entity? | Nuclear receptor-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01756","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESRRG and PPARG both interact with a shared protein. Evidence regarding this shared protein states: 'This repression correlates with a strong in vitro bindin... | |
medium_convergence_01757 | ELL2 and AFF1 both interact with a shared protein partner. Experimental evidence indicates that endogenous levels of this shared partner also exhibit the capacity to interact with ELL2. Which protein is encoded by this shared partner? | ELL-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_01757","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELL2 and AFF1 both interact with a shared protein partner. Experimental evidence indicates that endogenous levels of this shared partner also exhibit the cap... | |
medium_convergence_01758 | Both Orthohepevirus A and Enterovirus A are associated with the downregulation of a specific gene. Experimental data from a study on hepatocytes (GSE135619) indicates that this gene exhibits a log2 fold change of approximately -1.648 and an adjusted p-value of 0.04032. Which protein interacts with this downregulated ge... | SLC7A1 | Medium | convergence | {"qa_id":"medium_convergence_01758","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Enterovirus A are associated with the downregulation of a specific gene. Experimental data from a study on hepatocytes (GSE135619) ... | |
medium_convergence_01759 | ILF3 and NCL share a common interacting partner. Experimental evidence indicates that this shared partner forms protein complexes with DROSHA, Nucleolin, and XPO5, as detected by co-immunoprecipitation. Which disease is associated with this shared partner via a biomarker relationship? | esophagitis | Medium | convergence | {"qa_id":"medium_convergence_01759","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ILF3 and NCL share a common interacting partner. Experimental evidence indicates that this shared partner forms protein complexes with DROSHA, Nucleolin, and... | |
medium_convergence_01760 | Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately -1.53 and an adjusted p-value of approximately 0.0067. Which molecular function is enabled by this gene? | succinyl-CoA:3-oxo-acid CoA-transferase activity | Medium | convergence | {"qa_id":"medium_convergence_01760","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fol... | |
medium_convergence_01761 | ATM and CLSPN both interact with a shared protein. Evidence indicates that this shared protein, when phosphorylated, interacts with Claspin and regulates its phosphorylation. Which protein is encoded by the gene corresponding to this shared entity? | Cell cycle checkpoint protein RAD17 | Medium | convergence | {"qa_id":"medium_convergence_01761","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and CLSPN both interact with a shared protein. Evidence indicates that this shared protein, when phosphorylated, interacts with Claspin and regulates its... | |
medium_convergence_01762 | Betamethasone and Prednisolone both interact with a specific shared drug. Clinical evidence regarding this shared drug indicates that administration of prednisolone (0.5 mg/kg/day) combined with azathioprine failed to suppress clinical deterioration. Which drug interacts with this shared entity? | Deflazacort | Medium | convergence | {"qa_id":"medium_convergence_01762","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Betamethasone and Prednisolone both interact with a specific shared drug. Clinical evidence regarding this shared drug indicates that administration of predn... |
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