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medium_convergence_01542 | Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately -3.70 and an adjusted p-value of 0.01085. Which disease is associated with this gene? | amelogenesis imperfecta | Medium | convergence | {"qa_id":"medium_convergence_01542","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a l... | |
medium_convergence_01543 | COMMD1 and CUL3 both interact with a shared protein partner. Evidence indicates that in a complex with substrate-specific adaptors, this partner is required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis. Which cellular component is this partner locate... | Cul3-RING ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_01543","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 both interact with a shared protein partner. Evidence indicates that in a complex with substrate-specific adaptors, this partner is required ... | |
medium_convergence_01544 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. In a study of pleural mesothelioma cells (GSE117668), this gene exhibited a log2 fold change of -1.702 and an adjusted p-value of 0.0001111. Which protein is encoded by this gene? | Acyl-coenzyme A synthetase ACSM3, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_01544","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. In a study of pleural mesothelioma cells (GSE117668),... | |
medium_convergence_01545 | E2F1 and XRCC6 share common interacting partners. One such shared partner is implicated in the transactivation of the BRCA1 promoter through direct binding. Which protein is encoded by the gene corresponding to this shared interacting partner? | E3 ubiquitin-protein ligase RNF126 | Medium | convergence | {"qa_id":"medium_convergence_01545","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and XRCC6 share common interacting partners. One such shared partner is implicated in the transactivation of the BRCA1 promoter through direct binding. ... | |
medium_convergence_01546 | CTNNB1 and GSK3B share multiple interacting partners. One such partner is described by the following evidence: 'Upon Wnt signaling, a specific protein translocates into the nucleus, where it binds and retains β-catenin.' Which protein is encoded by this specific interacting partner? | Glucose-induced degradation protein 8 homolog | Medium | convergence | {"qa_id":"medium_convergence_01546","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and GSK3B share multiple interacting partners. One such partner is described by the following evidence: 'Upon Wnt signaling, a specific protein transl... | |
medium_convergence_01547 | AFF4 and GTF2F1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that a protein encoded by the gene MLLT1 contacts the scaffolding protein AFF4, which uses separate domains to recruit different subunits into the Super Elongation Complex (SEC). Which protein is encod... | Protein ENL | Medium | convergence | {"qa_id":"medium_convergence_01547","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AFF4 and GTF2F1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that a protein encoded by the gene MLL... | |
medium_convergence_01548 | IGF2BP1 and PACS2 share common interaction partners. One such partner is supported by evidence stating: 'Biochemical assays showed cIAP-1 and cIAP-2 interacted with PACS-2 in vitro and co-immunoprecipitation studies demonstrated that the two cIAPs bound PACS-2 in vivo.' Which protein is encoded by the gene correspondin... | Baculoviral IAP repeat-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01548","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IGF2BP1 and PACS2 share common interaction partners. One such partner is supported by evidence stating: 'Biochemical assays showed cIAP-1 and cIAP-2 interact... | |
medium_convergence_01549 | Both West Nile virus and Influenza A virus are known to upregulate the expression of a specific gene. Experimental data from monocyte-derived dendritic cells (study GSE136342) indicates that for one such shared target, the log2 fold change is 1.706 and the adjusted p-value is 0.02186. Which protein is encoded by this s... | S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 | Medium | convergence | {"qa_id":"medium_convergence_01549","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Influenza A virus are known to upregulate the expression of a specific gene. Experimental data from monocyte-derived dendritic cells... | |
medium_convergence_01550 | TAB2 and TAB3 share a common interaction partner. One such partner is described as an essential autophagy mediator that constitutively interacts with TAB2 and TAB3 via coiled-coil domains. Which protein is encoded by the gene corresponding to this shared interaction partner? | Beclin-1 | Medium | convergence | {"qa_id":"medium_convergence_01550","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB2 and TAB3 share a common interaction partner. One such partner is described as an essential autophagy mediator that constitutively interacts with TAB2 an... | |
medium_convergence_01551 | AP2M1 and AP2B1 both interact with a shared protein. Evidence indicates that this shared protein, when recombinantly expressed, interacts directly with the gamma-appendage domain of AP-1, with the clathrin N-terminal domain through the peptide motif (423)LFDLM, with the gamma-adaptin ear homology domain of Golgi-locali... | SEC16A | Medium | convergence | {"qa_id":"medium_convergence_01551","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2M1 and AP2B1 both interact with a shared protein. Evidence indicates that this shared protein, when recombinantly expressed, interacts directly with the g... | |
medium_convergence_01552 | CTNNB1 and EP400 share a common binding partner. Evidence regarding this shared partner states: 'Highly homologous to Pontin52, [the shared partner] likewise binds beta-catenin and TBP.' Which protein is encoded by this shared partner? | RuvB-like 2 | Medium | convergence | {"qa_id":"medium_convergence_01552","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and EP400 share a common binding partner. Evidence regarding this shared partner states: 'Highly homologous to Pontin52, [the shared partner] likewise... | |
medium_convergence_01553 | Both Measles morbillivirus and Cardiovirus A are reported to downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.155 and an adjusted p-value of 0.01869. Which cellular component is this gene located in? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_01553","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are reported to downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approx... | |
medium_convergence_01554 | Both Hepacivirus C and Dengue virus are known to upregulate a specific shared gene. Experimental evidence for this gene reports a log2 fold change of approximately 1.232 and an adjusted p-value of 3.798e-05. In which cell type is this gene enriched? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01554","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Dengue virus are known to upregulate a specific shared gene. Experimental evidence for this gene reports a log2 fold change of approxi... | |
medium_convergence_01555 | BMP7 and ACVR1B both interact with a common receptor. Evidence indicates that Activin binds directly to this common receptor, and this complex associates with ActR-IB, which does not bind ligand on its own. Which disease is associated with this shared receptor through genomic alterations? | premature ovarian failure 1 | Medium | convergence | {"qa_id":"medium_convergence_01555","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP7 and ACVR1B both interact with a common receptor. Evidence indicates that Activin binds directly to this common receptor, and this complex associates wit... | |
medium_convergence_01556 | ATM and ATR each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that ATR (the ATM- and Rad3-related protein kinase) phosphorylated specific sites on this partner in vitro. Which protein is encoded by the gene corresponding to this shared partner? | Serine/threonine-protein kinase Chk1 | Medium | convergence | {"qa_id":"medium_convergence_01556","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and ATR each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that ATR (the ATM- and Rad3-relate... | |
medium_convergence_01557 | Both the androgen receptor (AR) and the nuclear factor I/C (NFIC) protein interact with a common partner protein. Evidence indicates that this partner, identified as a subunit of the SWI/SNF chromatin remodeling complex, exhibits hormone-dependent interactions with AR via its FxxFF motif. Which disease is associated wi... | Coffin-Siris syndrome 11 | Medium | convergence | {"qa_id":"medium_convergence_01557","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and the nuclear factor I/C (NFIC) protein interact with a common partner protein. Evidence indicates that this partner, ident... | |
medium_convergence_01558 | DCAF7 and CBX1 share multiple interacting partners. One such partner is implicated in a process where, during stem cell differentiation, HP1β is phosphorylated at serine 89 by CK2, creating a binding site for the pluripotency regulator KAP1. Which disease is associated with this specific interacting partner? | Okur-Chung neurodevelopmental syndrome | Medium | convergence | {"qa_id":"medium_convergence_01558","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCAF7 and CBX1 share multiple interacting partners. One such partner is implicated in a process where, during stem cell differentiation, HP1β is phosphorylat... | |
medium_convergence_01559 | GH1 and INSR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'During a yeast tri-hybrid assay, phosphorylation of Ser(307) by JNK1 disrupted the interaction between the catalytic domain of the insulin receptor and the PTB domain of IRS-1.' Which disease is connected to th... | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01559","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH1 and INSR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'During a yeast tri-hybrid assay, phosphorylatio... | |
medium_convergence_01560 | KDM1A and TRIM33 both interact with a shared protein. Evidence indicates that this shared protein is associated with histone demethylase complexes containing lysine-specific demethylase 1 (LSD1), RE1 silencing transcription factor corepressor (CoREST), histone deacetylase 1 (HDAC1), and histone deacetylase 2 in erythro... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01560","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and TRIM33 both interact with a shared protein. Evidence indicates that this shared protein is associated with histone demethylase complexes containing... | |
medium_convergence_01561 | COMMD1 and CUL2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Recently, the VHL-Elongin BC complex was found to interact with a module composed of Cullin family member Cul2 and RING-H2 finger protein Rbx1 to reconstitute a novel E3 ubiquitin ligase that activates ubiquityl... | Elongin-C | Medium | convergence | {"qa_id":"medium_convergence_01561","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Recently, the VHL-Elongin BC complex was found t... | |
medium_convergence_01562 | CRK and CRKL share a common interaction partner. Evidence regarding one such partner states: 'By use of MALDI-TOF mass spectrometry, the protein was identified as a protein that specifically bound to Tyr900 in a phosphorylation dependent manner, possibly via the p85 subunit of PI3-kinase.' Which cellular component is t... | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_01562","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and CRKL share a common interaction partner. Evidence regarding one such partner states: 'By use of MALDI-TOF mass spectrometry, the protein was identifi... | |
medium_convergence_01563 | CHD3 and MBD3 each interact with a shared partner protein. Evidence concerning one such partner indicates that it interacts with MBD3 both in vitro and in vivo, co-localizes with MBD3 but not with MBD2, and does not localize to methyl-CpG-rich regions in the nucleus. Which molecular function is enabled by this specific... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01563","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and MBD3 each interact with a shared partner protein. Evidence concerning one such partner indicates that it interacts with MBD3 both in vitro and in vi... | |
medium_convergence_01564 | CRK and ABL1 share multiple interacting partners. One such shared partner is a kinase that binds to the Crk SH3 domain and phosphorylates c-Crk on tyrosine 221 (Y221), an activity attributed to c-Abl. Which cellular component is this shared partner located in? | actin cytoskeleton | Medium | convergence | {"qa_id":"medium_convergence_01564","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and ABL1 share multiple interacting partners. One such shared partner is a kinase that binds to the Crk SH3 domain and phosphorylates c-Crk on tyrosine 2... | |
medium_convergence_01565 | Both Vaccinia virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 5.18 and an adjusted p-value of approximately 1.83e-06. Which cell type is this gene enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01565","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line ... | |
medium_convergence_01566 | CCAR2 and TP53 both interact with a shared protein. Evidence regarding this shared protein states: 'Using yeast two-hybrid screening with this protein as bait, we isolated the p53 tumor suppressor protein as a specific interactor.' Which disease is associated with this shared protein through genomic alterations? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_01566","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCAR2 and TP53 both interact with a shared protein. Evidence regarding this shared protein states: 'Using yeast two-hybrid screening with this protein as bai... | |
medium_convergence_01567 | TOPBP1 and ERBB2 both interact with a specific shared gene product. Experimental evidence indicates that the c-erbB-2 gene product associates directly with this entity (along with beta-catenin) via its cytoplasmic domain core region, which shares extensive homology with the epidermal growth factor receptor. Which prote... | Junction plakoglobin | Medium | convergence | {"qa_id":"medium_convergence_01567","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and ERBB2 both interact with a specific shared gene product. Experimental evidence indicates that the c-erbB-2 gene product associates directly with t... | |
medium_convergence_01569 | DIS3 and EXOSC1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein is connected to that specific shared entity through the 'encode... | Exosome complex component RRP4 | Medium | convergence | {"qa_id":"medium_convergence_01569","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we demonstrate the associa... | |
medium_convergence_01570 | YAP1 and ERBB2 share a common interacting partner. Evidence regarding one such partner states: 'In this study, we show that a tyrosine kinase directly phosphorylates Yap1 at position Y357 in response to DNA damage.' Which disease is associated with this entity via genomic alterations? | T-cell childhood acute lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_01570","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and ERBB2 share a common interacting partner. Evidence regarding one such partner states: 'In this study, we show that a tyrosine kinase directly phosph... | |
medium_convergence_01571 | Both Human alphaherpesvirus 1 and Rhinovirus A are associated with the downregulation of a specific gene. In a study using a monocytic leukemia cell line (GSE114966), evidence for this shared target reports a log2 fold change of approximately -1.126 and an adjusted p-value of 0.02015. Which protein is encoded by this g... | Nuclear protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01571","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rhinovirus A are associated with the downregulation of a specific gene. In a study using a monocytic leukemia cell line (GS... | |
medium_convergence_01572 | Primary lung bud formation and prostatic bud formation are both subtypes of a specific biological process. Evidence regarding one of these subtypes states: 'The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.' Which biological process is the direct p... | morphogenesis of an epithelial fold | Medium | convergence | {"qa_id":"medium_convergence_01572","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primary lung bud formation and prostatic bud formation are both subtypes of a specific biological process. Evidence regarding one of these subtypes states: '... | |
medium_convergence_01573 | SMAD2 and FOXH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The ubiquitous nuclear protein Transcriptional Intermediary Factor 1gamma selectively binds receptor-phosphorylated Smad2/3 in competition with Smad4.' Which protein is encoded by the gene corre... | E3 ubiquitin-protein ligase TRIM33 | Medium | convergence | {"qa_id":"medium_convergence_01573","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD2 and FOXH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The ubiquitous nuclear protein ... | |
medium_convergence_01574 | FBXW11 and AGO2 both interact with a shared protein. Evidence for one such shared protein states: 'We found that both beta-Trcp1 and beta-Trcp2 bind specifically to this protein, and point mutations in the beta-Trcp WD-repeat region completely abolished its binding, indicating an E3-substrate-type interaction.' Which c... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_01574","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and AGO2 both interact with a shared protein. Evidence for one such shared protein states: 'We found that both beta-Trcp1 and beta-Trcp2 bind specific... | |
medium_convergence_01575 | CENPH and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a recently identified inner centromere component that plays crucial roles in the formation of a functional kinetochore involved in cell division during mitosis.' Whi... | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01575","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPH and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a ... | |
medium_convergence_01576 | MAD2L2 and MDM2 share interaction partners. One such shared partner is distinguished by evidence that its N-terminal region (or that of its paralog RPS27L) binds to the central acidic domain of MDM2. Which protein is encoded by this specific shared interaction partner? | Small ribosomal subunit protein eS27 | Medium | convergence | {"qa_id":"medium_convergence_01576","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAD2L2 and MDM2 share interaction partners. One such shared partner is distinguished by evidence that its N-terminal region (or that of its paralog RPS27L) b... | |
medium_convergence_01578 | PARP1 and HDAC2 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specifically interacts with poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme important in DNA repair and apoptosis.' Which biological process is this specific shar... | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_01578","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HDAC2 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specific... | |
medium_convergence_01580 | MDM2 and MYC share interaction partners. One such partner is described in the evidence as a DEAD-box RNA helicase identified as a nucleolar protein that interacts with MDM2. Which cellular component is this specific shared partner located in? | membrane | Medium | convergence | {"qa_id":"medium_convergence_01580","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and MYC share interaction partners. One such partner is described in the evidence as a DEAD-box RNA helicase identified as a nucleolar protein that inte... | |
medium_convergence_01581 | ACD and SMC3 each share a binding partner. Evidence concerning one such shared partner indicates that it interacts with the structural maintenance of chromosomes proteins SMC1 and SMC3, which are reported to be subunits of the mitotic cohesin complex. Which protein is encoded by this shared partner? | Cohesin subunit SA-3 | Medium | convergence | {"qa_id":"medium_convergence_01581","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACD and SMC3 each share a binding partner. Evidence concerning one such shared partner indicates that it interacts with the structural maintenance of chromos... | |
medium_convergence_01582 | CENPA and CENPH each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which protein is encoded by that entity? | Holliday junction recognition protein | Medium | convergence | {"qa_id":"medium_convergence_01582","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPH each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_01583 | Measles morbillivirus and Cardiovirus A both upregulate a specific gene. Evidence for this gene includes a log2 fold change of 1.361 and an adjusted p-value of 0.0236. Which cell type is this gene enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01583","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both upregulate a specific gene. Evidence for this gene includes a log2 fold change of 1.361 and an adjusted p-value ... | |
medium_convergence_01584 | BCOR and BCORL1 each interact with more than one shared protein. Evidence concerning one of these shared entities indicates that it is a component of a variant PRC1 complex that also contains the BCL6 co-repressor (the shared entity itself) and the histone demethylase KDM2B. Which protein is encoded by that shared enti... | Polycomb group RING finger protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01584","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCOR and BCORL1 each interact with more than one shared protein. Evidence concerning one of these shared entities indicates that it is a component of a varia... | |
medium_convergence_01585 | The biological processes 'negative regulation of antimicrobial humoral response' and 'negative regulation of innate immune response' share a common parent process in the ontology hierarchy. Evidence for one of these shared parent processes states: 'Any process that stops, prevents, or reduces the frequency, rate, or ex... | response to external stimulus | Medium | convergence | {"qa_id":"medium_convergence_01585","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'negative regulation of antimicrobial humoral response' and 'negative regulation of innate immune response' share a common parent pr... | |
medium_convergence_01587 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene exhibits a log2 fold change of approximately 1.229 and an adjusted p-value ... | POLR3GL | Medium | convergence | {"qa_id":"medium_convergence_01587","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from a ... | |
medium_convergence_01588 | STUB1 and TP53 both interact with a shared protein. Evidence indicates that this shared protein is encoded by the gene TP63, which physically interacts with CHIP (an E3 ligase with a U-box domain) and is promoted for degradation by it. Which protein is encoded by the gene corresponding to this shared entity? | Tumor protein 63 | Medium | convergence | {"qa_id":"medium_convergence_01588","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and TP53 both interact with a shared protein. Evidence indicates that this shared protein is encoded by the gene TP63, which physically interacts with ... | |
medium_convergence_01589 | CHD3 and HDAC2 share a common interaction partner. Experimental evidence indicates that this partner associates with several known components of the Mi2-NuRD complex, including HDAC1, HDAC2, MTA1, MBD3, p66, RbAp46, and RbAp48, in glutathione S-transferase pull-down assays. Which protein is encoded by this shared inter... | Methyl-CpG-binding domain protein 3-like 2 | Medium | convergence | {"qa_id":"medium_convergence_01589","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and HDAC2 share a common interaction partner. Experimental evidence indicates that this partner associates with several known components of the Mi2-NuRD... | |
medium_convergence_01590 | JUN and SRF share multiple interacting partners. One such partner is identified by evidence showing that Steroid receptor coactivator-1 (SRC-1) specifically binds to the transcription factor AP-1 subunits c-Jun and c-Fos, as demonstrated by yeast two-hybrid tests and glutathione S-transferase pull-down assays. Which pr... | Nuclear receptor coactivator 1 | Medium | convergence | {"qa_id":"medium_convergence_01590","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JUN and SRF share multiple interacting partners. One such partner is identified by evidence showing that Steroid receptor coactivator-1 (SRC-1) specifically ... | |
medium_convergence_01592 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.436 and an adjusted p-value of 0.02568. Which disease is associated with this gene as a biomarker? | atherosclerosis | Medium | convergence | {"qa_id":"medium_convergence_01592","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) r... | |
medium_convergence_01593 | LMNB1 and FZR1 share multiple interacting partners. One such partner is described in the following evidence: 'Here, we show that this protein interacts with two lamin A-binding proteins, proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1.' Which cellular compon... | mitotic spindle | Medium | convergence | {"qa_id":"medium_convergence_01593","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LMNB1 and FZR1 share multiple interacting partners. One such partner is described in the following evidence: 'Here, we show that this protein interacts with ... | |
medium_convergence_01594 | COPS5 and COPS4 both interact with a shared protein. Evidence indicates that this protein (referred to as TA) binds to CSN4 and the synaptic regulator snapin in neuroblastoma cells and brain synaptosomes. Which disease is associated with this protein via a biomarker relationship? | influenza | Medium | convergence | {"qa_id":"medium_convergence_01594","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and COPS4 both interact with a shared protein. Evidence indicates that this protein (referred to as TA) binds to CSN4 and the synaptic regulator snapin... | |
medium_convergence_01595 | UBA52 and UBC each interact with multiple shared partners. One such shared partner is implicated in evidence stating that OspG binds host E2 ubiquitin-conjugating enzymes activated with ubiquitin (E2~Ub), a key enzyme complex in ubiquitin transfer pathways. Which cellular component is this specific shared partner locat... | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_01595","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBA52 and UBC each interact with multiple shared partners. One such shared partner is implicated in evidence stating that OspG binds host E2 ubiquitin-conjug... | |
medium_convergence_01596 | YWHAQ and YWHAE both interact with a specific protein. Evidence for this protein states: 'We demonstrate direct and robust interaction between h[protein] and six of the seven 14-3-3 isoforms in vitro, suggestive of a novel protein interaction network between DNA repair and cell cycle control.' Which cellular component ... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_01596","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and YWHAE both interact with a specific protein. Evidence for this protein states: 'We demonstrate direct and robust interaction between h[protein] and... | |
medium_convergence_01597 | FGF1 and FGF2 each interact with multiple shared receptors. Evidence concerning one such shared receptor states: 'In solution, the receptor formed complexes with acidic FGF (FGF-1) and basic FGF (FGF-2), both in the presence and absence of heparin.' Which protein is encoded by that receptor gene? | Fibroblast growth factor receptor 4 | Medium | convergence | {"qa_id":"medium_convergence_01597","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF2 each interact with multiple shared receptors. Evidence concerning one such shared receptor states: 'In solution, the receptor formed complexes ... | |
medium_convergence_01598 | HDAC1 and HDAC2 share a common interaction partner. Evidence for this partner indicates that it interacts with HDAC1 both in the cell and in vitro. Which biological process is this shared partner involved in? | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_01598","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC2 share a common interaction partner. Evidence for this partner indicates that it interacts with HDAC1 both in the cell and in vitro. Which bio... | |
medium_convergence_01599 | Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.366 and an adjusted p-value of 4.774e-07. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01599","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately... | |
medium_convergence_01600 | CHUK and PDPK1 share multiple interacting partners. One specific shared interactor is supported by evidence identifying PKC-zeta, PKC-delta, and PRK2 as interactors of PDK1. Which disease is associated with this specific shared interactor via a biomarker relationship? | cervical squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01600","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and PDPK1 share multiple interacting partners. One specific shared interactor is supported by evidence identifying PKC-zeta, PKC-delta, and PRK2 as inte... | |
medium_convergence_01601 | ATP6V1G3 and LAMTOR2 both interact with a shared protein partner. Evidence indicates that this partner is part of a complex (termed Ragulator) encoded by the MAPKSP1, ROBLD3, and c11orf59 genes, which interacts with Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation. Which protein is encode... | Ras-related GTP-binding protein C | Medium | convergence | {"qa_id":"medium_convergence_01601","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP6V1G3 and LAMTOR2 both interact with a shared protein partner. Evidence indicates that this partner is part of a complex (termed Ragulator) encoded by the... | |
medium_convergence_01602 | Pegaspargase and Cyclosporine both interact with a specific drug. Clinical evidence indicates that when this drug is used to treat toxoplasmosis in heart transplant recipients, it decreases the concentration of Cyclosporine. Which disease is this drug indicated for? | rheumatic fever | Medium | convergence | {"qa_id":"medium_convergence_01602","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Cyclosporine both interact with a specific drug. Clinical evidence indicates that when this drug is used to treat toxoplasmosis in heart tra... | |
medium_convergence_01603 | AKAP10 and PRKACA both interact with a shared protein partner. Evidence regarding this partner states: 'Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha.' Which protein is encoded by the gene corresponding to this shared partner? | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_01603","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP10 and PRKACA both interact with a shared protein partner. Evidence regarding this partner states: 'Based on coprecipitation assays, the R binding domain... | |
medium_convergence_01604 | EPS15 and GRB2 both interact with a specific shared protein. Evidence indicates that this shared protein binds to the intracellular adaptor protein GRB2, suggesting an intracellular localization. Which protein is encoded by the gene corresponding to this shared entity? | Protein sprouty homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_01604","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS15 and GRB2 both interact with a specific shared protein. Evidence indicates that this shared protein binds to the intracellular adaptor protein GRB2, sug... | |
medium_convergence_01605 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells from study GSE102481 reports a log2 fold change of 3.883 and an adjusted p-value of 0.001022. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01605","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells from study GSE102481 reports a lo... | |
medium_convergence_01606 | CHRNA3 and SLC18A3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that P2X2 co-immunoprecipitated the α3β2 nicotinic acetylcholine receptor (nAChR), but not the α4β2 nAChR, in both HEK cells and rat hippocampal membranes, indicating a physical associati... | nicotine dependence | Medium | convergence | {"qa_id":"medium_convergence_01606","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRNA3 and SLC18A3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that P2X2 co-immunopreci... | |
medium_convergence_01607 | BIRC5 and CENPP share a common interaction partner. Experimental evidence indicates that Survivin binds directly to both Aurora-B and this shared partner in yeast two-hybrid and in vitro pull-down assays. Which protein is encoded by this shared partner? | Inner centromere protein | Medium | convergence | {"qa_id":"medium_convergence_01607","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC5 and CENPP share a common interaction partner. Experimental evidence indicates that Survivin binds directly to both Aurora-B and this shared partner in ... | |
medium_convergence_01608 | GLRX3 and YWHAQ both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We report the isolation and characterization of a cDNA encoding a novel 335-amino acid (37.5-kDa) PKCtheta-interacting protein termed PICOT (for PKC-interacting cousin of thioredoxin).' Which protein is en... | Protein kinase C theta type | Medium | convergence | {"qa_id":"medium_convergence_01608","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GLRX3 and YWHAQ both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We report the isolation and characterizati... | |
medium_convergence_01609 | CTNNB1 and WWOX share a common interacting partner. Evidence indicates that this shared partner binds to β-catenin and inhibits its degradation. Which protein is encoded by the gene corresponding to this shared partner? | Translocation protein SEC62 | Medium | convergence | {"qa_id":"medium_convergence_01609","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and WWOX share a common interacting partner. Evidence indicates that this shared partner binds to β-catenin and inhibits its degradation. Which protei... | |
medium_convergence_01610 | Both Human alphaherpesvirus 3 and Pegivirus C are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.105 and an adjusted p-value of 4.346e-06. What is the name of the protein encode... | Mitochondrial import inner membrane translocase subunit Tim21 | Medium | convergence | {"qa_id":"medium_convergence_01610","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Pegivirus C are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line study (G... | |
medium_convergence_01611 | Mast cell homeostasis and monocyte homeostasis share a common biological process category. Evidence regarding one such shared category describes the regulation of mast cell proliferation and elimination to maintain a stable total number of mast cells in an organism over time, absent external stimuli. Which cell type is... | leukocyte | Medium | convergence | {"qa_id":"medium_convergence_01611","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Mast cell homeostasis and monocyte homeostasis share a common biological process category. Evidence regarding one such shared category describes the regulati... | |
medium_convergence_01613 | MSTN and INHBA both interact with a common receptor protein. Experimental evidence indicates that Biotinylated inhibin A, but not activin A, binds to this shared receptor. Which protein, encoded by the gene corresponding to this shared receptor, is the target of the 'encodes' relationship? | Activin receptor type-1B | Medium | convergence | {"qa_id":"medium_convergence_01613","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MSTN and INHBA both interact with a common receptor protein. Experimental evidence indicates that Biotinylated inhibin A, but not activin A, binds to this sh... | |
medium_convergence_01614 | HDAC1 and NFIB share common interaction partners. One such shared partner is reported to preferably interact with HDAC1 and mSin3A. Which protein is encoded by this shared partner? | MHC class II regulatory factor RFX1 | Medium | convergence | {"qa_id":"medium_convergence_01614","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and NFIB share common interaction partners. One such shared partner is reported to preferably interact with HDAC1 and mSin3A. Which protein is encoded ... | |
medium_convergence_01615 | CREBBP and IFIH1 each interact with more than one shared gene. Evidence concerning one shared entity reports that phosphorylation of this entity induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein. Which disease is connected to that entity through a biomar... | arteriosclerosis disorder | Medium | convergence | {"qa_id":"medium_convergence_01615","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and IFIH1 each interact with more than one shared gene. Evidence concerning one shared entity reports that phosphorylation of this entity induced its ... | |
medium_convergence_01616 | Both RIG-I and RIPK1 interact with a specific protein that functions as a novel negative regulator in antiviral responses by binding to and deubiquitinating RIG-I. Which protein is encoded by the gene corresponding to this regulatory entity? | Ubiquitin carboxyl-terminal hydrolase 21 | Medium | convergence | {"qa_id":"medium_convergence_01616","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both RIG-I and RIPK1 interact with a specific protein that functions as a novel negative regulator in antiviral responses by binding to and deubiquitinating ... | |
medium_convergence_01617 | ACTR3 and AP2A1 both interact with a shared protein partner. Evidence regarding this partner indicates that its NTA region interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which disease is associated with th... | esophageal squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01617","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and AP2A1 both interact with a shared protein partner. Evidence regarding this partner indicates that its NTA region interacts directly with the Arp2/3... | |
medium_convergence_01618 | BIRC2 and BIRC3 both interact with a shared protein. Evidence regarding this interaction states: 'In support of this we show that the BIR domains 2 and 3 of the two cIAPs are able to bind caspases-7 and -9.' Which disease is associated with this shared protein? | mantle cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_01618","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a shared protein. Evidence regarding this interaction states: 'In support of this we show that the BIR domains 2 and 3 of ... | |
medium_convergence_01619 | Dyphylline and Mycophenolic acid both interact with a specific shared drug. Evidence regarding this shared drug indicates that it significantly decreased the excretion of Dyphylline, demonstrating that Dyphylline occupied the renal organic anion transport system. Which disease is this shared drug indicated for? | gout | Medium | convergence | {"qa_id":"medium_convergence_01619","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dyphylline and Mycophenolic acid both interact with a specific shared drug. Evidence regarding this shared drug indicates that it significantly decreased the... | |
medium_convergence_01620 | VPS25 and CHMP4C both interact with a shared protein partner. Evidence regarding one such partner describes a complex with three lobes containing one copy each of VPS22 and the partner, along with two copies of VPS25. Which protein is encoded by the gene corresponding to this partner? | Vacuolar protein-sorting-associated protein 36 | Medium | convergence | {"qa_id":"medium_convergence_01620","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS25 and CHMP4C both interact with a shared protein partner. Evidence regarding one such partner describes a complex with three lobes containing one copy ea... | |
medium_convergence_01621 | Both Orthohepevirus A and Enterovirus A are reported to downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) show a log2 fold change of -1.148 and an adjusted p-value of 0.04032. Which disease is associated with this gene? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01621","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Enterovirus A are reported to downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) s... | |
medium_convergence_01622 | CFTR and CSNK2A1 share a common interacting partner. Evidence regarding this shared partner states: 'We demonstrate here that EGFR activation results in disruption of the complex of beta-catenin and alpha-catenin, thereby abrogating the inhibitory effect of alpha-catenin on beta-catenin transactivation via CK2alpha-dep... | Catenin alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_01622","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and CSNK2A1 share a common interacting partner. Evidence regarding this shared partner states: 'We demonstrate here that EGFR activation results in disr... | |
medium_convergence_01623 | YAP1 and H2AFZ share common interacting partners. One such shared partner is described by evidence stating that its binding to Yes-associated protein 1 (YAP1) influences YAP1 stability, and that silencing this partner inhibits YAP1 expression by promoting its ubiquitination and degradation in cardiac fibroblasts. Which... | Nucleosome assembly protein 1-like 1 | Medium | convergence | {"qa_id":"medium_convergence_01623","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and H2AFZ share common interacting partners. One such shared partner is described by evidence stating that its binding to Yes-associated protein 1 (YAP1... | |
medium_convergence_01624 | PRMT5 and CLNS1A share a common interacting partner. Evidence indicates that this shared partner and pICln bind to PRMT5 in a mutually exclusive fashion. Which protein is encoded by this shared interacting partner? | Serine/threonine-protein kinase RIO1 | Medium | convergence | {"qa_id":"medium_convergence_01624","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and CLNS1A share a common interacting partner. Evidence indicates that this shared partner and pICln bind to PRMT5 in a mutually exclusive fashion. Whi... | |
medium_convergence_01625 | YAP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with a specific interacting partner has an additive effect on promoter activity, and the proteins were demonstrated to interact physically.' Which disease is associated... | mammary neoplasms, animal | Medium | convergence | {"qa_id":"medium_convergence_01625","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with ... | |
medium_convergence_01627 | ELOB and CUL2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We show that the interaction with cullins is independent of ubiquitin- and substrate-binding. Instead, it relies on the UIM motif in this protein that directly engages the NEDD8 modification on cullins.' Which... | UBX domain-containing protein 7 | Medium | convergence | {"qa_id":"medium_convergence_01627","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELOB and CUL2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We show that the interaction with cullins is i... | |
medium_convergence_01628 | ANAPC16 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protein, CDC20, and MAD2 in near equal stoichiometry. Which disease is associated with this shared protein? | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_01628","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC16 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protei... | |
medium_convergence_01629 | STUB1 and MKRN1 both interact with a specific shared gene product. Experimental evidence indicates that CHIP (C terminus of Hsc70-interacting protein) physically associates with this entity in the cytoplasm and regulates its cellular abundance through ubiquitin-mediated degradation. Which protein is encoded by this gen... | Telomerase reverse transcriptase | Medium | convergence | {"qa_id":"medium_convergence_01629","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and MKRN1 both interact with a specific shared gene product. Experimental evidence indicates that CHIP (C terminus of Hsc70-interacting protein) physic... | |
medium_convergence_01630 | Both Human betaherpesvirus 5 and Human orthopneumovirus are associated with the upregulation of a specific shared gene entity. Experimental evidence for this entity in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.059 and an adjusted p-value of 3.308e-05. Which protein is encoded by this ... | Histone H2B type 1-C/E/F/G/I | Medium | convergence | {"qa_id":"medium_convergence_01630","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Human orthopneumovirus are associated with the upregulation of a specific shared gene entity. Experimental evidence for this... | |
medium_convergence_01631 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.15 and an adjusted p-value of approximately 0.0186. Which protein is encoded by this gene? | Transcription factor JunB | Medium | convergence | {"qa_id":"medium_convergence_01631","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_01632 | HSP90AA1 and HSP90AB1 both interact with a shared protein. Evidence indicates that this specific shared protein is a client of Hsp90 in vivo. Which cell type is enriched for this protein? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01632","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and HSP90AB1 both interact with a shared protein. Evidence indicates that this specific shared protein is a client of Hsp90 in vivo. Which cell type... | |
medium_convergence_01633 | HDAC2 and RBPJ share multiple interacting partners. One such shared partner is characterized by its association with transcriptional repressors including KAP1, histone deacetylases HDAC1/2, and the histone methyltransferase G9a/GLP, and it modulates the interaction of HDAC1 and KAP1 with heterochromatin. Which protein ... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_01633","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and RBPJ share multiple interacting partners. One such shared partner is characterized by its association with transcriptional repressors including KAP... | |
medium_convergence_01634 | Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.94 and an adjusted p-value of 0.020. Which disease is associated with genomic alterations in this gene? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_01634","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study ... | |
medium_convergence_01635 | RBCK1 and MAP3K7 both interact with a shared protein partner. Evidence regarding this partner indicates that it forms a linear ubiquitin chain assembly complex (LUBAC) and ubiquitylates NEMO. Which protein is encoded by the gene corresponding to this shared partner? | E3 ubiquitin-protein ligase RNF31 | Medium | convergence | {"qa_id":"medium_convergence_01635","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBCK1 and MAP3K7 both interact with a shared protein partner. Evidence regarding this partner indicates that it forms a linear ubiquitin chain assembly compl... | |
medium_convergence_01636 | HSPA5 and MYC share multiple interacting partners. One such shared partner is known to directly interact with c-Myc and stabilize its protein levels by preventing proteasomal degradation. Which protein is encoded by this specific shared partner? | Polypyrimidine tract-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01636","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA5 and MYC share multiple interacting partners. One such shared partner is known to directly interact with c-Myc and stabilize its protein levels by preve... | |
medium_convergence_01637 | GRB2 and ELOC both interact with a common protein. Evidence indicates that this shared protein binds to Elongin-C and promotes the ubiquitination of HIF-1alpha. Which protein is encoded by the gene corresponding to this shared entity? | Small ribosomal subunit protein RACK1 | Medium | convergence | {"qa_id":"medium_convergence_01637","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and ELOC both interact with a common protein. Evidence indicates that this shared protein binds to Elongin-C and promotes the ubiquitination of HIF-1alp... | |
medium_convergence_01638 | GABARAP and MAP1LC3C both interact with a shared protein. Evidence indicates that this shared protein binds to ATG8-family proteins with higher affinity than p62. Which cell type is this protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01638","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABARAP and MAP1LC3C both interact with a shared protein. Evidence indicates that this shared protein binds to ATG8-family proteins with higher affinity than... | |
medium_convergence_01641 | FBXW11 and YWHAE both interact with a specific protein. Evidence indicates that TGF-beta-induced ubiquitination of this protein is associated with its phosphorylation at the beta-TrCP docking site (DS82G motif) and its physical association with Smad3 and beta-TrCP. Which protein is encoded by the gene corresponding to ... | M-phase inducer phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_01641","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and YWHAE both interact with a specific protein. Evidence indicates that TGF-beta-induced ubiquitination of this protein is associated with its phosph... | |
medium_convergence_01642 | MYC and XRCC5 share multiple interacting partners. One such shared partner is reported to interact with Ku70 and Ku80, which are major players in the DNA repair process. Which protein is encoded by this shared partner? | Coilin | Medium | convergence | {"qa_id":"medium_convergence_01642","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and XRCC5 share multiple interacting partners. One such shared partner is reported to interact with Ku70 and Ku80, which are major players in the DNA rep... | |
medium_convergence_01643 | HDAC1 and SP1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that this protein is associated with histone demethylase complexes containing lysine-specific demethylase 1 (LSD1), RE1 silencing transcription factor corepressor (CoREST), histone deacetylas... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01643","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and SP1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that this protein is associa... | |
medium_convergence_01644 | ESR1 and HMGA1 share common interaction partners. One such partner is described in the context: 'However, HMG I(Y) physically interacts with the conserved POU domains of both Oct-1 and Oct-2A.' Which protein is encoded by the gene corresponding to this shared interaction partner? | POU domain, class 2, transcription factor 2 | Medium | convergence | {"qa_id":"medium_convergence_01644","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HMGA1 share common interaction partners. One such partner is described in the context: 'However, HMG I(Y) physically interacts with the conserved PO... | |
medium_convergence_01645 | Both Vaccinia virus and Measles morbillivirus are known to downregulate a specific host gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -2.645 and an adjusted p-value of 0.02383. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01645","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Measles morbillivirus are known to downregulate a specific host gene. In a study using a cervical adenocarcinoma cell line (GSE11238)... | |
medium_convergence_01646 | HRAS and RHOA share multiple interacting partners. One such partner is distinguished by evidence showing it specifically interacts with both dominant-negative and nucleotide-free forms of H-Ras and N-Ras, but not with their corresponding oncogenic forms. Which cell type is enriched for this specific interacting partner... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01646","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and RHOA share multiple interacting partners. One such partner is distinguished by evidence showing it specifically interacts with both dominant-negativ... | |
medium_convergence_01647 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 2.32 and an adjusted p-value of 0.025. Which protein is encoded by this gene? | Serine/threonine-protein kinase PLK2 | Medium | convergence | {"qa_id":"medium_convergence_01647","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports ... | |
medium_convergence_01648 | COMMD1 and CUL2 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We show that the interaction with cullins is independent of ubiquitin- and substrate-binding. Instead, it relies on the UIM motif in the protein that directly engages the NEDD8 modification on cullins.' Which p... | UBX domain-containing protein 7 | Medium | convergence | {"qa_id":"medium_convergence_01648","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL2 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We show that the interaction with cullins is in... | |
medium_convergence_01649 | Both ABL1 and HSP90AA1 interact with a specific shared protein. Experimental evidence indicates that this shared protein forms a complex with the Mr 10,000 Abl SH2 protein. Which protein is encoded by the gene corresponding to this shared entity? | Breakpoint cluster region protein | Medium | convergence | {"qa_id":"medium_convergence_01649","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ABL1 and HSP90AA1 interact with a specific shared protein. Experimental evidence indicates that this shared protein forms a complex with the Mr 10,000 A... | |
medium_convergence_01650 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of -1.525 and an adjusted p-value of 0.03425. Which disease is associated with this gene through genomic alterations? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_01650","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE13208... |
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