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medium_convergence_01428 | GSK3B and MDM2 share multiple interacting partners. One such shared partner was identified as a specific MDM2-binding protein using a yeast two-hybrid screen. Which protein is encoded by this shared partner? | Telethonin | Medium | convergence | {"qa_id":"medium_convergence_01428","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and MDM2 share multiple interacting partners. One such shared partner was identified as a specific MDM2-binding protein using a yeast two-hybrid screen... | |
medium_convergence_01429 | YBX1 and PRKN (also known as PARK2) share common interaction partners. One such shared partner is reported to form a complex with YBX1 to promote PFKFB4 transcription. Which protein is encoded by this shared interaction partner? | THO complex subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_01429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YBX1 and PRKN (also known as PARK2) share common interaction partners. One such shared partner is reported to form a complex with YBX1 to promote PFKFB4 tran... | |
medium_convergence_01430 | ATM and ATR each interact with more than one shared protein. Evidence concerning one shared entity reports that the ATM- and Rad3-related protein kinase phosphorylated both of these sites in vitro. Which cell type is enriched for that entity? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01430","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and ATR each interact with more than one shared protein. Evidence concerning one shared entity reports that the ATM- and Rad3-related protein kinase phos... | |
medium_convergence_01431 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.39 and an adjusted p-value of approximately 2.76e-05. Which protein interacts with this downregulated gene? | CDK5RAP3 | Medium | convergence | {"qa_id":"medium_convergence_01431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) ... | |
medium_convergence_01432 | ERCC2 and EAF2 share a common interacting partner. Evidence regarding this partner states: 'The complementation of XPB and XPD is a consequence of ERCC3 and ERCC2 being integral subunits of a transcription factor complex, whereas complementation of XPC is due to an association of this polypeptide with this complex.' Wh... | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_01432","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC2 and EAF2 share a common interacting partner. Evidence regarding this partner states: 'The complementation of XPB and XPD is a consequence of ERCC3 and ... | |
medium_convergence_01433 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of -1.431 and an adjusted p-value of 0.02798. What molecular function is enabled by this gene? | deaminated glutathione amidase activity | Medium | convergence | {"qa_id":"medium_convergence_01433","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_01434 | PEX13 and DDO each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity and PEX13 formed a complex with PTS1-loaded Pex5p but dissociated in the presence of cargo-unloaded Pex5p, implying that PTS cargoes are released from Pex5p at a step downstream of this entity a... | Peroxisomal membrane protein PEX14 | Medium | convergence | {"qa_id":"medium_convergence_01434","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PEX13 and DDO each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity and PEX13 formed a complex with... | |
medium_convergence_01435 | FAAP100 and ATRIP both interact with a common protein. Evidence indicates that this shared protein forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which gene does this shared protein interact with? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_01435","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAAP100 and ATRIP both interact with a common protein. Evidence indicates that this shared protein forms a conserved DNA-remodeling complex with the histone-... | |
medium_convergence_01436 | CREBBP and GATA1 both interact with a specific protein. Evidence regarding this protein states: 'Here we report the characterization of ternary complexes formed by the KIX domain of CBP and the transactivation domain of the trithorax group protein [REDACTED]...'. Which protein is encoded by the gene corresponding to th... | Histone-lysine N-methyltransferase 2A | Medium | convergence | {"qa_id":"medium_convergence_01436","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and GATA1 both interact with a specific protein. Evidence regarding this protein states: 'Here we report the characterization of ternary complexes for... | |
medium_convergence_01437 | Cerebellar Golgi cell differentiation and cerebellar granule cell differentiation are both specific types of a broader biological process. Evidence regarding one of these specific processes states: 'The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature c... | hindbrain development | Medium | convergence | {"qa_id":"medium_convergence_01437","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cerebellar Golgi cell differentiation and cerebellar granule cell differentiation are both specific types of a broader biological process. Evidence regarding... | |
medium_convergence_01439 | OS9 and DERL1 both interact with a specific E3 ubiquitin ligase. Evidence indicates that Derlin-1 retains CFTR in the ER membrane and interacts with this shared partner and Ubc6e to promote CFTR's proteasomal degradation. Which protein is encoded by the gene corresponding to this shared interaction partner? | E3 ubiquitin-protein ligase RNF5 | Medium | convergence | {"qa_id":"medium_convergence_01439","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OS9 and DERL1 both interact with a specific E3 ubiquitin ligase. Evidence indicates that Derlin-1 retains CFTR in the ER membrane and interacts with this sha... | |
medium_convergence_01440 | PARD6A and PARD3 both interact with a specific protein. Evidence indicates that this protein associates with ASIP/PAR-3 and a mammalian homologue of C. elegans PAR-6 (mPAR-6) to form an aPKC-ASIP/PAR-3-PAR-6 ternary complex that localizes to the apical junctional region of MDCK cells. Which protein is encoded by the ge... | Protein kinase C iota type | Medium | convergence | {"qa_id":"medium_convergence_01440","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARD6A and PARD3 both interact with a specific protein. Evidence indicates that this protein associates with ASIP/PAR-3 and a mammalian homologue of C. elega... | |
medium_convergence_01441 | SIRT1 and SUZ12 both interact with a specific shared protein. Evidence indicates that SIRT1 interacts directly with this protein and is recruited to the promoter template in a manner dependent on this protein, resulting in transcriptional repression. Which protein is encoded by the gene corresponding to this shared ent... | BCL11 transcription factor A | Medium | convergence | {"qa_id":"medium_convergence_01441","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and SUZ12 both interact with a specific shared protein. Evidence indicates that SIRT1 interacts directly with this protein and is recruited to the prom... | |
medium_convergence_01442 | The otic region and the olfactory region are both anatomical parts of a shared cranial structure. Evidence indicates that this shared structure is an anatomical cluster located in the anterior region of the cranium and provides structural support for the olfactory organ. What is the primary classification of this share... | primary subdivision of skull | Medium | convergence | {"qa_id":"medium_convergence_01442","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The otic region and the olfactory region are both anatomical parts of a shared cranial structure. Evidence indicates that this shared structure is an anatomi... | |
medium_convergence_01443 | HDAC1 and GATAD2B both interact with a shared protein. Evidence indicates that an affinity-purified HDAC1 corepressor complex contains this shared protein, suggesting that MeCP1 corresponds to a fraction of this complex. Which protein is encoded by the gene corresponding to this shared entity? | Methyl-CpG-binding domain protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01443","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and GATAD2B both interact with a shared protein. Evidence indicates that an affinity-purified HDAC1 corepressor complex contains this shared protein, s... | |
medium_convergence_01444 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) reports a log2 fold change of approximately 2.56 and an adjusted p-value of approximately 0.046. ... | Vasculin | Medium | convergence | {"qa_id":"medium_convergence_01444","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_01445 | HIST1H1A and HIST1H1C share interaction partners. One such shared partner is involved in a complex where H1.2 stably interacts with Cul4A E3 ubiquitin ligase and this partner's elongation complexes, an interaction that potentiates target gene transcription via induction of H4K31 ubiquitylation, H3K4me3, and H3K79me2. W... | RNA polymerase II-associated factor 1 homolog | Medium | convergence | {"qa_id":"medium_convergence_01445","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST1H1A and HIST1H1C share interaction partners. One such shared partner is involved in a complex where H1.2 stably interacts with Cul4A E3 ubiquitin ligase... | |
medium_convergence_01446 | TRIM28 and GSK3B share multiple interacting partners. One such shared partner is described by the following evidence: 'We show that this protein directly interacts with KAP1 and ubiquitinates it in vitro and in the cellular environment in a catalytically-dependent manner.' Which protein is encoded by this shared intera... | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_01446","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and GSK3B share multiple interacting partners. One such shared partner is described by the following evidence: 'We show that this protein directly int... | |
medium_convergence_01447 | C11orf30 and GATAD1 share multiple interacting partners. One such partner is implicated in evidence stating: 'Recent work from others and us revealed interactions between the Sin3/HDAC complex, the H3K4me3 demethylase [ENTITY], GATAD1, and EMSY.' Which cellular component is this [ENTITY] located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_01447","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C11orf30 and GATAD1 share multiple interacting partners. One such partner is implicated in evidence stating: 'Recent work from others and us revealed interac... | |
medium_convergence_01448 | YAP1 and KAT5 share multiple protein interaction partners. One such shared partner is implicated in a study stating: 'In this study, we found that YAP-CREB interaction is critical for liver cancer cell survival and maintenance of transformative phenotypes, both in vitro and in vivo.' Which protein is encoded by this sh... | Cyclic AMP-responsive element-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01448","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and KAT5 share multiple protein interaction partners. One such shared partner is implicated in a study stating: 'In this study, we found that YAP-CREB i... | |
medium_convergence_01449 | ABI2 and DAG1 share common interacting partners. One such partner is identified in a study using a GST fusion protein of the beta-dystroglycan cytoplasmic tail, which revealed five SH2 domain-containing proteins (including c-Src, Fyn, Csk, a specific adaptor protein, and SHC) that interact with beta-dystroglycan in a p... | basophil | Medium | convergence | {"qa_id":"medium_convergence_01449","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABI2 and DAG1 share common interacting partners. One such partner is identified in a study using a GST fusion protein of the beta-dystroglycan cytoplasmic ta... | |
medium_convergence_01450 | STK35 and PDIK1L each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Through mass spectrometry analysis of affinity-purified complexes, we identify the kinase paralogs STK35 and PDIK1L as binding partners and substrates of the SCP4 phosphatase domain.' Which protein is ... | CTD small phosphatase-like protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01450","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STK35 and PDIK1L each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Through mass spectrometry analysis of ... | |
medium_convergence_01451 | EPC1 and AJUBA both interact with a shared protein. Evidence indicates that this shared entity is a proliferation-specific Polycomb group (PcG) protein identified as an EPC1-interacting protein. Which protein is encoded by this shared entity? | Histone-lysine N-methyltransferase EZH2 | Medium | convergence | {"qa_id":"medium_convergence_01451","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPC1 and AJUBA both interact with a shared protein. Evidence indicates that this shared entity is a proliferation-specific Polycomb group (PcG) protein ident... | |
medium_convergence_01452 | Human alphaherpesvirus 1 and Influenza A virus both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.345 and an adjusted p-value of 0.003693. Which protein is encoded by this gene? | Retinol-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01452","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Influenza A virus both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GS... | |
medium_convergence_01453 | EGFR and MYH9 share a common interacting partner. Evidence indicates that for this shared partner, ligand-induced recruitment of a specific ubiquitin-binding protein into activated complexes inhibits receptor internalization, reduces the number of endocytic vesicles containing the receptor, blocks receptor degradation,... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_01453","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and MYH9 share a common interacting partner. Evidence indicates that for this shared partner, ligand-induced recruitment of a specific ubiquitin-binding... | |
medium_convergence_01456 | Both Human polyomavirus 1 and Measles morbillivirus are known to upregulate a specific host gene. Experimental data from a study on renal epithelial cells (GSE135833) indicates that for one such shared target, the log2 fold change is 1.059 and the adjusted p-value is 0.01824. Which protein is encoded by this specific g... | High mobility group protein B2 | Medium | convergence | {"qa_id":"medium_convergence_01456","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Measles morbillivirus are known to upregulate a specific host gene. Experimental data from a study on renal epithelial cells (G... | |
medium_convergence_01457 | PCNA and RFC2 both interact with a specific protein. Evidence indicates that in vitro, this protein engages ubiquitylated PCNA via both a PIP box and a UBZ domain. Which protein is encoded by the gene corresponding to this shared interaction partner? | DNA-dependent metalloprotease SPRTN | Medium | convergence | {"qa_id":"medium_convergence_01457","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and RFC2 both interact with a specific protein. Evidence indicates that in vitro, this protein engages ubiquitylated PCNA via both a PIP box and a UBZ d... | |
medium_convergence_01458 | ACVR1C and ACVR1B each interact with more than one shared gene product. Evidence concerning one shared entity reports that Biotinylated inhibin A, but not activin A, bound ALK4. Which protein is encoded by that entity? | Inhibin beta A chain | Medium | convergence | {"qa_id":"medium_convergence_01458","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACVR1C and ACVR1B each interact with more than one shared gene product. Evidence concerning one shared entity reports that Biotinylated inhibin A, but not ac... | |
medium_convergence_01459 | CEP164 and ATR both interact with a specific gene product. Evidence indicates that the protein encoded by this gene product interacts with the checkpoint proteins ATR and Rad9. Which protein is encoded by this gene product? | Claspin | Medium | convergence | {"qa_id":"medium_convergence_01459","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEP164 and ATR both interact with a specific gene product. Evidence indicates that the protein encoded by this gene product interacts with the checkpoint pro... | |
medium_convergence_01460 | Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) indicate a log2 fold change of approximately 1.081 and an adjusted p-value of 0.007784. Which cellular component is this gene located in? | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_01460","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study G... | |
medium_convergence_01461 | RPA1 and RPA2 both interact with a specific shared protein. Experimental evidence indicates that RPA physically interacts with this protein to form RPA-protein-H3.3 complexes and co-localizes with it and H3.3 at gene promoters and enhancers. Which protein is encoded by the gene corresponding to this shared interaction ... | Protein HIRA | Medium | convergence | {"qa_id":"medium_convergence_01461","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA1 and RPA2 both interact with a specific shared protein. Experimental evidence indicates that RPA physically interacts with this protein to form RPA-prote... | |
medium_convergence_01462 | CLK3 and HMGB1 share common interaction partners. One such partner was identified as a binding partner of HMGB1 using LC-MS/MS, proximity ligation assay, and immunoprecipitation, with the aim of investigating the ubiquitination of HMGB1. Which protein is encoded by this specific shared interaction partner? | Ubiquitin carboxyl-terminal hydrolase 13 | Medium | convergence | {"qa_id":"medium_convergence_01462","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLK3 and HMGB1 share common interaction partners. One such partner was identified as a binding partner of HMGB1 using LC-MS/MS, proximity ligation assay, and... | |
medium_convergence_01463 | KHDRBS1 and HSP90AA1 both interact with a specific shared protein. Evidence regarding this shared protein indicates that the formation of an intramolecular SH3-ligand complex prevents its SH3 domain and proline-rich region from interacting with their respective protein ligands, Sam68 and Grb-2. Which protein is encoded... | Tyrosine-protein kinase ITK/TSK | Medium | convergence | {"qa_id":"medium_convergence_01463","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and HSP90AA1 both interact with a specific shared protein. Evidence regarding this shared protein indicates that the formation of an intramolecular S... | |
medium_convergence_01464 | The androgen receptor (AR) and the microtubule-associated protein tau (MAPT) both interact with a specific shared protein. Experimental evidence indicates that for this shared protein, PC-1 interacts with it and the E3 ligase CHIP, enhancing their interaction and thereby decreasing the stability of the shared protein. ... | Tumor protein D52 | Medium | convergence | {"qa_id":"medium_convergence_01464","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The androgen receptor (AR) and the microtubule-associated protein tau (MAPT) both interact with a specific shared protein. Experimental evidence indicates th... | |
medium_convergence_01465 | YAP1 and MYBBP1A share a common interaction partner. Evidence indicates that this shared partner interacts with YAP1 to enhance CTGF expression through histone methylation. Which disease is associated with this shared partner via genomic alterations? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01465","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and MYBBP1A share a common interaction partner. Evidence indicates that this shared partner interacts with YAP1 to enhance CTGF expression through histo... | |
medium_convergence_01466 | TP53 and CUL1 share multiple interacting partners. One such partner is identified by evidence stating: 'Pull-down and co-immunoprecipitation assays demonstrated that p53 interacts specifically with this partner both in vitro and in vivo.' Which cell type is enriched for this specific interacting partner? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01466","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and CUL1 share multiple interacting partners. One such partner is identified by evidence stating: 'Pull-down and co-immunoprecipitation assays demonstra... | |
medium_convergence_01468 | BMPR1B and ACVR2A both interact with a common protein partner. Experimental evidence regarding this partner states: 'Using antibody-mediated immunofluorescence copatching of epitope-tagged receptors, we provide evidence in live cells for preexisting heteromeric (BR-II/BR-Ia and BR-II/BR-Ib) and homomeric (BR-II/BR-II, ... | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_01468","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMPR1B and ACVR2A both interact with a common protein partner. Experimental evidence regarding this partner states: 'Using antibody-mediated immunofluorescen... | |
medium_convergence_01470 | Pegaspargase and Morphine both interact with a specific drug. Evidence regarding this drug states: 'Based on these results, it can be concluded that MET attenuates the development of morphine analgesic tolerance and dependence in rats.' Which disease is this drug indicated for? | type 2 diabetes mellitus | Medium | convergence | {"qa_id":"medium_convergence_01470","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Morphine both interact with a specific drug. Evidence regarding this drug states: 'Based on these results, it can be concluded that MET atte... | |
medium_convergence_01472 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.519 and an adjusted p-value of 0.04216. Wh... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_01472","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for thi... | |
medium_convergence_01473 | Human immunodeficiency virus 1 and Pegivirus C both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 1.157 and an adjusted p-value of 0.004596. Which protein is encoded by this gene? | DNA-binding protein inhibitor ID-1 | Medium | convergence | {"qa_id":"medium_convergence_01473","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human immunodeficiency virus 1 and Pegivirus C both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of ap... | |
medium_convergence_01474 | CFL1 and DSTN both interact with a shared gene product. Evidence regarding this shared entity indicates that vertebrate cofilin binds to it but does not increase yeast actin filament flexibility, nor does it sever the filaments. Which cell type is enriched for this shared entity? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01474","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFL1 and DSTN both interact with a shared gene product. Evidence regarding this shared entity indicates that vertebrate cofilin binds to it but does not incr... | |
medium_convergence_01475 | CDK2 and CDKN1A share multiple interacting partners. One such shared partner is implicated in the following observation: In response to CDK7 inhibition, p21 binding to CDK4 increased concomitantly with the disappearance of the most abundant phosphorylation of p21 (localized at S130), which was found to be catalyzed by ... | cyclin-dependent protein kinase holoenzyme complex | Medium | convergence | {"qa_id":"medium_convergence_01475","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CDKN1A share multiple interacting partners. One such shared partner is implicated in the following observation: In response to CDK7 inhibition, p21 ... | |
medium_convergence_01476 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. In cytotoxic T-lymphocytes, evidence for this gene shows a log2 fold change of approximately 2.56 and an adjusted p-value of approximately 0.0207. Which cellular component is this gene located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_01476","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. In cytotoxic T-lymphocytes, evidence for this gene shows a log2 fold change of approximately ... | |
medium_convergence_01477 | DDX20 and CTBP1 both interact with a shared protein partner. Evidence indicates that this partner enhances the transcriptional repression of SMURF2 (a negative regulator of TGF-β/SMAD2 signaling) through its interaction with the transcription repressor CTBP1. Which protein is encoded by this shared partner? | Transcription factor E2F4 | Medium | convergence | {"qa_id":"medium_convergence_01477","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX20 and CTBP1 both interact with a shared protein partner. Evidence indicates that this partner enhances the transcriptional repression of SMURF2 (a negati... | |
medium_convergence_01478 | PARP1 and DNMT3A share interaction partners. One such shared partner is characterized by evidence stating: 'Using peptide arrays and binding to native histone proteins, we show that the ADD domain of Dnmt3a specifically interacts with the H3 histone 1-19 tail.' Which protein is encoded by this shared entity? | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_01478","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and DNMT3A share interaction partners. One such shared partner is characterized by evidence stating: 'Using peptide arrays and binding to native histon... | |
medium_convergence_01479 | Both Human alphaherpesvirus 1 and Zika virus are known to upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE100576) reports a log2 fold change of approximately 1.709 and an adjusted p-value of 0.008871. Which protein does this upregulated gene product bind to? | ISG15 | Medium | convergence | {"qa_id":"medium_convergence_01479","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zika virus are known to upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (stud... | |
medium_convergence_01480 | ESR1 and HSP90AA1 share multiple interacting partners. One such partner is characterized by evidence stating that it directly interacts with the ligand binding domain of ER and is recruited to the proximal promoter regions of ER target genes upon gene induction. Which protein is encoded by this specific interacting par... | Histone-lysine N-methyltransferase SMYD3 | Medium | convergence | {"qa_id":"medium_convergence_01480","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HSP90AA1 share multiple interacting partners. One such partner is characterized by evidence stating that it directly interacts with the ligand bindi... | |
medium_convergence_01483 | DIS3 and EXOSC10 both interact with a shared protein partner. Evidence regarding this partner states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein is encoded by this shared partner? | Exosome complex component RRP4 | Medium | convergence | {"qa_id":"medium_convergence_01483","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC10 both interact with a shared protein partner. Evidence regarding this partner states: 'Here, we demonstrate the association of two different ... | |
medium_convergence_01484 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene exhibits a log2 fold change of approximately 1.23 and an adjusted ... | DNA-directed RNA polymerase III subunit RPC7 | Medium | convergence | {"qa_id":"medium_convergence_01484","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental dat... | |
medium_convergence_01485 | NOX1 and RAC1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Using Nox1 siRNA, we show that Nox1-dependent superoxide production affects the migration of HT29-D4 colonic adenocarcinoma cells on collagen-I.' Which cell type is connected to that sp... | M1 macrophage | Medium | convergence | {"qa_id":"medium_convergence_01485","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOX1 and RAC1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Using Nox1 siRNA, we s... | |
medium_convergence_01486 | KRAS and RHOA both interact with a specific protein. Evidence indicates that this protein, along with Rac1, binds to a guanine nucleotide exchange factor in both active and inactive forms, a process requiring poly-basic residues in the C-termini of the GTPases. Which disease is associated with this protein? | Alfadhel syndrome | Medium | convergence | {"qa_id":"medium_convergence_01486","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and RHOA both interact with a specific protein. Evidence indicates that this protein, along with Rac1, binds to a guanine nucleotide exchange factor in ... | |
medium_convergence_01487 | Alteplase and Reteplase both interact with a specific drug. Clinical evidence suggests that Platelet GP IIb/IIIa receptor antagonists may be suitable as a single therapeutic or as an adjunct to thrombolysis with this specific drug for the treatment of stroke. Which disease is this specific drug indicated for? | acute coronary syndrome | Medium | convergence | {"qa_id":"medium_convergence_01487","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Alteplase and Reteplase both interact with a specific drug. Clinical evidence suggests that Platelet GP IIb/IIIa receptor antagonists may be suitable as a si... | |
medium_convergence_01489 | NR3C1 and PPARG share common interaction partners. One such partner is supported by evidence stating: 'Immunoprecipitation and glutathione S-transferase pull-down assay showed that a specific nuclear receptor corepressor directly bound to PPARgamma and competed with nuclear receptor corepressor for binding to PPARgamma... | Nuclear receptor subfamily 0 group B member 2 | Medium | convergence | {"qa_id":"medium_convergence_01489","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and PPARG share common interaction partners. One such partner is supported by evidence stating: 'Immunoprecipitation and glutathione S-transferase pull... | |
medium_convergence_01490 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately -1.676 and an adjusted p-value of approximately 0.0338. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | convergence | {"qa_id":"medium_convergence_01490","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_01491 | EGLN3 and EGLN1 both interact with a specific protein. Evidence states: 'Here, we demonstrate that this protein, the protein product of a widely expressed gene, interacts with both HIF-1alpha and HIF-1alpha prolyl hydroxylases.' Which cell type is this protein enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01491","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGLN3 and EGLN1 both interact with a specific protein. Evidence states: 'Here, we demonstrate that this protein, the protein product of a widely expressed ge... | |
medium_convergence_01492 | Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific host gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene exhibits a log2 fold change of -1.786 and an adjusted p-value of 0.006225. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01492","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific host gene. Experimental data from a study on macrophages (GSE108897... | |
medium_convergence_01493 | FGFR1 and PTPN23 both interact with a specific shared protein. Evidence indicates that this shared protein is HD-PTP, an ESCRT protein that forms complexes with ESCRT-0, -I, and -III proteins and binds to Endofin, a FYVE-domain protein confined to endosomes. Which protein is encoded by the gene corresponding to this sh... | Ankyrin repeat and FYVE domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01493","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGFR1 and PTPN23 both interact with a specific shared protein. Evidence indicates that this shared protein is HD-PTP, an ESCRT protein that forms complexes w... | |
medium_convergence_01494 | Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of -1.454 and an adjusted p-value of 0.002139. Which protein does this gene product bind to? | RHOBTB1 | Medium | convergence | {"qa_id":"medium_convergence_01494","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of -1.454 and an adju... | |
medium_convergence_01495 | TRIM28 and CHEK1 share a common interacting partner. Evidence regarding one such partner states: 'We identified a novel interaction between this protein and checkpoint kinase CHK1 and showed that the defective damage response in cells deficient for this protein is at least in part due to altered CHK1 subcellular locali... | Ogden syndrome | Medium | convergence | {"qa_id":"medium_convergence_01495","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CHEK1 share a common interacting partner. Evidence regarding one such partner states: 'We identified a novel interaction between this protein and ... | |
medium_convergence_01496 | SFN and YWHAB both interact with a shared protein. Evidence for this shared protein states: 'We demonstrate direct and robust interaction between hEXO1 and six of the seven 14-3-3 isoforms in vitro, suggestive of a novel protein interaction network between DNA repair and cell cycle control.' Which cellular component is... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_01496","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SFN and YWHAB both interact with a shared protein. Evidence for this shared protein states: 'We demonstrate direct and robust interaction between hEXO1 and s... | |
medium_convergence_01497 | IFIH1 and BCL10 both interact with a common protein. Evidence regarding this shared partner states: 'Here, we show that Bcl10 undergoes K63-linked polyubiquitination in response to T cell activation and subsequently binds the regulatory subunit of IKK.' Which protein is encoded by this shared partner? | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_01497","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFIH1 and BCL10 both interact with a common protein. Evidence regarding this shared partner states: 'Here, we show that Bcl10 undergoes K63-linked polyubiqui... | |
medium_convergence_01498 | Both Human alphaherpesvirus 3 and Pegivirus C are known to downregulate a specific host gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.101 and an adjusted p-value of 3.622e-05. In which cellular component is the protein produc... | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_01498","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Pegivirus C are known to downregulate a specific host gene. Experimental data from a melanoma cell line study (GSE136586) i... | |
medium_convergence_01499 | RIPK1 and IKBKE each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'In the present study, a TNFAIP3 protein interacted with RIP1 and DR4 in MGC803 and SGC7901 gastric cancer cells.' Which disease is associated with that entity via a biomarker relationship? | myocarditis | Medium | convergence | {"qa_id":"medium_convergence_01499","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIPK1 and IKBKE each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'In the present study, a TNFAIP3 ... | |
medium_convergence_01500 | ALK and RHOA share multiple protein interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected it alongside SHP2 as a validated interactor of ALK in neuroblastoma (NB) cells. Which protein is encoded by the gene corresponding to this shared interaction partner? | Inactive tyrosine-protein kinase PEAK1 | Medium | convergence | {"qa_id":"medium_convergence_01500","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and RHOA share multiple protein interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected it alongside SHP2 as a... | |
medium_convergence_01502 | ERBB2 and PLCG1 both interact with a shared protein. Evidence indicates that the PLCgamma1-SH3 domain associates with the human Ras guanine nucleotide exchange factor son-of-sevenless-2 (hSos2) via a proline-rich domain interaction. Which protein is encoded by the gene corresponding to this shared entity? | Son of sevenless homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_01502","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and PLCG1 both interact with a shared protein. Evidence indicates that the PLCgamma1-SH3 domain associates with the human Ras guanine nucleotide exchan... | |
medium_convergence_01503 | KAT5 and COPS5 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we report that the histone acetyltransferase Tip60 and the histone deacetylase HDAC7 interact with one of the ET receptors, ETA, as determined by yeast two-hybrid analysis, glutathione S-transferase pull... | Endothelin-1 receptor | Medium | convergence | {"qa_id":"medium_convergence_01503","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and COPS5 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we report that the histone acetyltransfe... | |
medium_convergence_01504 | ATG14 and HLA-G share common interaction partners. One such shared partner is distinguished by the following evidence: although both this entity and UVRAG interact with Beclin 1 and the class III phosphatidylinositol 3-kinase catalytic subunit, they are not present in the same complex. Which disease is associated with ... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_01504","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG14 and HLA-G share common interaction partners. One such shared partner is distinguished by the following evidence: although both this entity and UVRAG in... | |
medium_convergence_01505 | CAND1 and CUL3 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'To define the molecular basis for this assembly and the overall architecture of the E3, we determined the crystal structures of the BTB-BACK domains of this entity both alone and in complex with Cul3, along with... | LNX1 | Medium | convergence | {"qa_id":"medium_convergence_01505","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL3 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'To define the molecular basis for this assembly ... | |
medium_convergence_01506 | MYC and SMURF1 share multiple interaction partners. One such shared partner is described in the following evidence: 'Here, we show that Smurf1 interacts with [Entity], a core component of the U3 snoRNP complex, which is involved in pre-rRNA processing.' Which protein is encoded by this shared entity? | U3 small nucleolar RNA-interacting protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01506","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and SMURF1 share multiple interaction partners. One such shared partner is described in the following evidence: 'Here, we show that Smurf1 interacts with... | |
medium_convergence_01508 | CSTF1 and CDC5L each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In the protein product of CSTF2, a small region, highly conserved in metazoa, is responsible for interactions with two proteins, CstF-77 and symplekin, a nuclear protein of previously unknown functio... | Cleavage stimulation factor subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_01508","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSTF1 and CDC5L each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In the protein product of CSTF2, a s... | |
medium_convergence_01510 | RPA2 and CLSPN both interact with a specific protein. Evidence indicates that this protein forms a complex with RPA, CLASPIN, and RAD17, which are involved in DNA replication checkpoint functions. Which protein is this shared interaction partner? | TIMELESS-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_01510","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA2 and CLSPN both interact with a specific protein. Evidence indicates that this protein forms a complex with RPA, CLASPIN, and RAD17, which are involved i... | |
medium_convergence_01511 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.168 and an adjusted p-value of 2.019e-05. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01511","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data for this gene in a melan... | |
medium_convergence_01512 | DLAT and GRSF1 both interact with a shared protein. Evidence indicates that the binding of this shared protein and PDK2 is readily reversible, with an apparent dissociation constant of approximately 10 microM for both isoenzymes. Which disease is associated with this shared protein? | severe combined immunodeficiency | Medium | convergence | {"qa_id":"medium_convergence_01512","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLAT and GRSF1 both interact with a shared protein. Evidence indicates that the binding of this shared protein and PDK2 is readily reversible, with an appare... | |
medium_convergence_01513 | Both POLA1 and ACD share a common interaction partner. Evidence regarding this shared partner states: 'Conversely, a pol1 peptide spanning the last 16 residues binds primase with high affinity, and the equivalent peptide from human Pol α binds primase in an analogous fashion.' Which protein is connected to this shared ... | DNA primase large subunit | Medium | convergence | {"qa_id":"medium_convergence_01513","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both POLA1 and ACD share a common interaction partner. Evidence regarding this shared partner states: 'Conversely, a pol1 peptide spanning the last 16 residu... | |
medium_convergence_01514 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in a lung fibroblast cell line (study GSE120891) reports a log2 fold change of approximately 3.15 and an adjusted p-value of approximately 0.035. Which ce... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01514","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_01515 | GGA3 and GGA1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that GGA3 is monoubiquitylated by a RING-H2 type-ubiquitin ligase hVPS18 (human homologue of vacuolar protein sorting 18).' Which protein is connected to that entity through the 'encodes' rel... | Vacuolar protein sorting-associated protein 18 homolog | Medium | convergence | {"qa_id":"medium_convergence_01515","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GGA3 and GGA1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that GGA3 is monoubiquitylat... | |
medium_convergence_01516 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene shows a log2 fold change of 1.088 and an adjusted p-value of 0.04043. Which disease is associated with this gene through genomic alterations? | polycystic ovary syndrome | Medium | convergence | {"qa_id":"medium_convergence_01516","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene shows a log2 fold change of 1.088 and an adjusted p-value of 0.04043. ... | |
medium_convergence_01517 | STUB1 and ALDOA both interact with a specific protein. Experimental evidence indicates that this protein was co-immunoprecipitated with Aldolase A in COS-7 cells overexpressing both the protein and Aldolase A, and that Aldolase A exhibited binding properties similar to those of Aldolase C in this context. Which protein... | Phospholipase D2 | Medium | convergence | {"qa_id":"medium_convergence_01517","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and ALDOA both interact with a specific protein. Experimental evidence indicates that this protein was co-immunoprecipitated with Aldolase A in COS-7 c... | |
medium_convergence_01519 | CRYAA and CRYAB both interact with a shared protein. Experimental evidence indicates that alpha-crystallins bind to this shared entity and Bcl-X(S) both in vitro and in vivo, as demonstrated by GST pulldown assays and coimmunoprecipitations. Which disease is associated with this shared entity via a biomarker relationsh... | benign prostatic hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_01519","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRYAA and CRYAB both interact with a shared protein. Experimental evidence indicates that alpha-crystallins bind to this shared entity and Bcl-X(S) both in v... | |
medium_convergence_01520 | RIMS1 and PPFIA2 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that the active zone components Munc13-1, an essential vesicle priming protein, and RIM1, a Rab3 effector with a putative role in vesicle tethering, interact functionally.' Which protein is encoded by the gene... | Protein unc-13 homolog B | Medium | convergence | {"qa_id":"medium_convergence_01520","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIMS1 and PPFIA2 both interact with a shared protein partner. Evidence regarding this partner states: 'We show that the active zone components Munc13-1, an e... | |
medium_convergence_01521 | POLR2H and GTF3C4 both interact with a shared protein partner. Evidence regarding this partner describes novel interactions of hTFIIIC63 with hTFIIIC102, hTFIIIB90, and hRPC62, as well as hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel those in yeast. Which protein is encoded by this shared partner... | DNA-directed RNA polymerase III subunit RPC3 | Medium | convergence | {"qa_id":"medium_convergence_01521","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2H and GTF3C4 both interact with a shared protein partner. Evidence regarding this partner describes novel interactions of hTFIIIC63 with hTFIIIC102, hTF... | |
medium_convergence_01522 | Human alphaherpesvirus 3 and Cardiovirus A both upregulate a specific gene. Evidence for this shared target in a melanoma cell line (study GSE136586) reports a log2 fold change of 6.805 and an adjusted p-value of 6.261e-14. Which protein is encoded by this gene? | C-X-C motif chemokine 10 | Medium | convergence | {"qa_id":"medium_convergence_01522","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Cardiovirus A both upregulate a specific gene. Evidence for this shared target in a melanoma cell line (study GSE136586) reports... | |
medium_convergence_01523 | Both West Nile virus and Zika virus are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cells reports a log2 fold change of approximately 1.415 and an adjusted p-value of 0.04609. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01523","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Zika virus are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cells repor... | |
medium_convergence_01524 | NPM3 and EP300 share multiple interacting partners. One such shared partner is characterized by evidence showing it interacts with ERalpha, as well as with the general transcriptional coactivators p300 and the cAMP response element-binding protein-binding protein. Which protein is encoded by this shared partner? | Proline-, glutamic acid- and leucine-rich protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01524","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NPM3 and EP300 share multiple interacting partners. One such shared partner is characterized by evidence showing it interacts with ERalpha, as well as with t... | |
medium_convergence_01525 | Oxytocin and Morphine both interact with a specific drug. Evidence indicates that this drug modulates the antinociceptive and rewarding effects of morphine in an animal model of osteoarthritic pain. Which disease is this drug indicated for? | major depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_01525","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Oxytocin and Morphine both interact with a specific drug. Evidence indicates that this drug modulates the antinociceptive and rewarding effects of morphine i... | |
medium_convergence_01526 | RAD51AP1 and PHLPP1 share a common interacting partner. Evidence indicates that this shared partner binds to PHLPP and directly removes polyubiquitin chains from PHLPP in vitro and in cells. Which cellular component is this shared partner located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_01526","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51AP1 and PHLPP1 share a common interacting partner. Evidence indicates that this shared partner binds to PHLPP and directly removes polyubiquitin chains ... | |
medium_convergence_01527 | GEMIN5 and GEMIN6 both interact with a shared protein partner. Evidence indicates that this specific partner interacts directly with SMN and mediates the association of GEMIN6 with the SMN complex. Which protein is encoded by the gene corresponding to this shared partner? | Gem-associated protein 7 | Medium | convergence | {"qa_id":"medium_convergence_01527","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GEMIN5 and GEMIN6 both interact with a shared protein partner. Evidence indicates that this specific partner interacts directly with SMN and mediates the ass... | |
medium_convergence_01528 | CD2BP2 and CPSF1 both interact with a shared protein partner. Evidence regarding this partner states: 'We also show that 160K binds specifically to both the 77K (suppressor of forked) subunit of the cleavage factor CstF and to poly(A) polymerase (PAP).' Which protein is encoded by the gene corresponding to this shared ... | Cleavage stimulation factor subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_01528","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD2BP2 and CPSF1 both interact with a shared protein partner. Evidence regarding this partner states: 'We also show that 160K binds specifically to both the ... | |
medium_convergence_01529 | HUS1B and CSNK2B each interact with more than one shared protein. Evidence concerning one shared entity reports: 'However, HUS1B directly interacts with this protein, but not RAD9 or HUS1, whereas HUS1 can bind this protein, RAD9, and another molecule of HUS1, suggesting that HUS1B cannot simply substitute for HUS1 in ... | Cell cycle checkpoint protein RAD1 | Medium | convergence | {"qa_id":"medium_convergence_01529","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUS1B and CSNK2B each interact with more than one shared protein. Evidence concerning one shared entity reports: 'However, HUS1B directly interacts with this... | |
medium_convergence_01530 | ACAD9 and NDUFA2 both interact with a shared protein. Evidence indicates that this shared protein interacts with complex I assembly factors, including Ecsit, and is specifically required for the assembly of complex I. Which protein is encoded by this shared entity? | Complex I intermediate-associated protein 30, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_01530","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACAD9 and NDUFA2 both interact with a shared protein. Evidence indicates that this shared protein interacts with complex I assembly factors, including Ecsit,... | |
medium_convergence_01531 | YWHAQ and AKT1 share multiple interacting partners. One such partner is supported by evidence showing that PKC theta and 14-3-3 tau coimmunoprecipitated from Jurkat T cells, and that recombinant 14-3-3 tau interacted directly with purified PKC theta in vitro. Which disease is associated with this specific interacting p... | schwannoma | Medium | convergence | {"qa_id":"medium_convergence_01531","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and AKT1 share multiple interacting partners. One such partner is supported by evidence showing that PKC theta and 14-3-3 tau coimmunoprecipitated from... | |
medium_convergence_01532 | EP300 and SIRT1 both interact with a specific shared protein. Evidence indicates that the co-activator p300 binds to and acetylates this shared entity in vivo, thereby inhibiting its function. Which disease is associated with this entity through genomic alterations? | gonorrhea | Medium | convergence | {"qa_id":"medium_convergence_01532","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SIRT1 both interact with a specific shared protein. Evidence indicates that the co-activator p300 binds to and acetylates this shared entity in viv... | |
medium_convergence_01533 | CDT1 and CDC45 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We found that CDC45 can directly interact with all MCM2-7 proteins; with PSF2, PSF3 and SLD5 in GINS subunits; and with replication protein A2 (RPA2), AND-1 and topoisomerase 2-binding protein 1.' Which protein ... | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_01533","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDT1 and CDC45 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We found that CDC45 can directly interact with a... | |
medium_convergence_01534 | CCDC22 and CUL3 both interact with a shared protein partner. Evidence indicates that in a complex containing this partner and KLHL9, CUL3 is required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis. Which gene interacts with this shared partner? | KLHL21 | Medium | convergence | {"qa_id":"medium_convergence_01534","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL3 both interact with a shared protein partner. Evidence indicates that in a complex containing this partner and KLHL9, CUL3 is required for cor... | |
medium_convergence_01535 | Both Hepacivirus C and Zaire ebolavirus are associated with the upregulation of a specific gene. Experimental data for this gene, derived from peripheral blood mononuclear cells, reports a log2 fold change of approximately 1.43 and an adjusted p-value of 0.0021. Which biological process is this gene involved in? | signal transduction | Medium | convergence | {"qa_id":"medium_convergence_01535","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are associated with the upregulation of a specific gene. Experimental data for this gene, derived from peripheral blo... | |
medium_convergence_01536 | Both Human alphaherpesvirus 3 and Zika virus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.168 and an adjusted p-value of 2.019e-05. Which protein is encoded by this gene? | DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF | Medium | convergence | {"qa_id":"medium_convergence_01536","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE... | |
medium_convergence_01537 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line reports a log2 fold change of 1.669 and an adjusted p-value of 0.003917. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01537","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line reports a log2 fold change of... | |
medium_convergence_01538 | The facial vein and the palpebral vein share a common anatomical classification. Evidence regarding one of these shared categories describes a vessel that commences at the side of the root of the nose as a direct continuation of the angular vein, receiving a small nasal branch. This vessel lies behind the facial artery... | craniocervical region | Medium | convergence | {"qa_id":"medium_convergence_01538","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The facial vein and the palpebral vein share a common anatomical classification. Evidence regarding one of these shared categories describes a vessel that co... | |
medium_convergence_01540 | GATA4 and FOXO4 both interact with a specific transcription factor. Evidence regarding this interaction states: 'The synergy involves physical [transcription factor]-GATA-4 interaction, seen in vitro and in vivo, which maps to the C-terminal zinc finger of GATA-4 and a C-terminus extension; similarly, a C-terminally ex... | myotonic dystrophy | Medium | convergence | {"qa_id":"medium_convergence_01540","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA4 and FOXO4 both interact with a specific transcription factor. Evidence regarding this interaction states: 'The synergy involves physical [transcription... | |
medium_convergence_01541 | GNG4 and ARRB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Immunoprecipitation experiments demonstrated that beta-arrestin 1 physically interacts with delta opioid receptor (DOR) co-expressed in human embryonic kidney 293 cells in an agonist-enhanced manner and trunc... | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01541","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNG4 and ARRB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Immunoprecipitation experiments demonstrated ... |
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