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medium_hidden_intermediate_10347 | Hepacivirus C upregulates a gene that is involved in the phospholipid metabolic process. Evidence for this specific gene reports a log2 fold change of 1.036 and an adjusted p-value of 0.005938. Which protein is encoded by this gene? | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the phospholipid metabolic process. Evidence for this specific gene rep... | |
medium_hidden_intermediate_10348 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to NR1H2 and NR1H3-mediated signaling via a 'participates in' relationship. One of these genes is associated with experimental evidence showing a log2 fold change of approximately -1.48 and ... | TUBA1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10348","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_10350 | Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn enriched in plasmacytoid dendritic cells. Experimental data for this gene in foreskin fibroblast cell lines (study GSE130665) indicate a log2 fold change of approximately 1.06 and an adjusted p-value of 0.0009637. Which protein is encod... | Uncharacterized protein C8orf88 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10350","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn enriched in plasmacytoid dendritic cells... | |
medium_hidden_intermediate_10353 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to obesity disorder via an association relationship. One of these genes exhibits a log2 fold change of approximately -2.06 and an adjusted p-value of approximately 0.017 in macrophages from study GSE108897. Which b... | calcitriol biosynthetic process from calciol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to obesity disorde... | |
medium_hidden_intermediate_10355 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its protein product binds to MRPL46. Evidence for this gene reports a log2 fold change of 1.402 and an adjusted p-value of 0.03495. Which protein is encoded by this gene? | Small ribosomal subunit protein mS37 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10355","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_10356 | Zika virus downregulates a specific gene, which in turn interacts with BAG2. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.99 and an adjusted p-value of 0.0128. Which biological process is this gene involved in? | positive regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10356","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with BAG2. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_10357 | GNA15 interacts with a specific G protein-coupled receptor that exhibits G protein-coupled receptor activity. This receptor is identified as a member of the subfamily of proton-sensing GPCRs. Which disease is associated with this receptor as a biomarker? | rectal prolapse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10357","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNA15 interacts with a specific G protein-coupled receptor that exhibits G protein-coupled receptor activity. This receptor ... | |
medium_hidden_intermediate_10361 | Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for this specific gene reports a log2 fold change of 2.391 and an adjusted p-value of 0.03246. Which biological process is this gene involved in? | glycosaminoglycan biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10361","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives... | |
medium_hidden_intermediate_10364 | Hepacivirus C upregulates multiple genes that are located in the lysosomal membrane. One such gene exhibits a log2 fold change of 2.137 and an adjusted p-value of 2.667e-05. Which cell type is this specific gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates multiple genes that are located in the lysosomal membrane. One such gene exhibits a log2 fold chan... | |
medium_hidden_intermediate_10365 | Zaire ebolavirus downregulates a gene that participates in Metabolism. Experimental data for this gene in retinal pigment epithelium cells (study GSE100839) show a log2 fold change of -1.540 and an adjusted p-value of 0.007406. Which protein is encoded by this gene? | Platelet glycoprotein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10365","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that participates in Metabolism. Experimental data for this gene in retinal pigment ep... | |
medium_hidden_intermediate_10366 | Zika virus downregulates a specific gene, which in turn interacts with NIFK. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -3.807 and an adjusted p-value of 0.005849. What molecular function is enabled by this gene? | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with NIFK. Experimental data from glioma stem cells (study... | |
medium_hidden_intermediate_10368 | A gene is downregulated by Zika virus and associated with multiple sclerosis. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.556 and an adjusted p-value of 0.003065. Which protein is encoded by this gene? | Protein Dr1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10368","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and associated with multiple sclerosis. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_10369 | Hepacivirus C is reported to downregulate a gene that enables 3-hydroxybutyrate dehydrogenase activity. In a specific study, this gene exhibited a log2 fold change of approximately -1.091 and an adjusted p-value of 0.01554. Which protein is encoded by this gene? | Dehydrogenase/reductase SDR family member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10369","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables 3-hydroxybutyrate dehydrogenase activity. In a specific study,... | |
medium_hidden_intermediate_10370 | In a study of Measles morbillivirus infection, two genes are upregulated by the virus and interact with RAB11A. One of these genes exhibits a log2 fold change of 1.750 and an adjusted p-value of 0.04985. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are upregulated by the virus and interact with RAB11A. One of these... | |
medium_hidden_intermediate_10373 | Zika virus downregulates a gene located in the chromosome telomeric region. Evidence for one such gene reports a log2 fold change of -2.362 and an adjusted p-value of 0.002664. Which disease is associated with that gene? | neuroblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10373","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene located in the chromosome telomeric region. Evidence for one such gene reports a log2 fold c... | |
medium_hidden_intermediate_10374 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Mitotic Anaphase. Experimental data for this gene shows a log2 fold change of approximately 1.16 and an adjusted p-value of 0.0089. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10374","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Mitotic Anaphase. Experim... | |
medium_hidden_intermediate_10375 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAF/MAP kinase cascade. One of these genes shows a log2 fold change of -1.855 and an adjusted p-value of 0.006947 in a specific study. Which protein is encoded by this gene? | cGMP-dependent protein kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10375","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAF/MAP kinase c... | |
medium_hidden_intermediate_10376 | Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular region. Evidence for one such gene reports a log2 fold change of 1.750 and an adjusted p-value of 0.01005. Which disease is associated with that gene? | tuberculosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular region. Evidence for one such gene reports ... | |
medium_hidden_intermediate_10378 | Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to the Neuronal System via a participation relationship. One of these genes exhibits a log2 fold change of -2.527 and an adjusted p-value of 0.01256 in peripheral blood mononuclear cells (study GSE131504). Which diseas... | cocaine dependence | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10378","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to the Neuronal System... | |
medium_hidden_intermediate_10379 | Human alphaherpesvirus 1 upregulates a gene that is located in the cytoplasm. Evidence for this specific gene reports a log2 fold change of 1.044 and an adjusted p-value of 0.009448. Which protein is encoded by this gene? | FH1/FH2 domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the cytoplasm. Evidence for this specific gene reports a log2... | |
medium_hidden_intermediate_10381 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of lipids. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) show a log2 fold change of approximately -1.94 and an adjusted p-value of approximately 0.041. Which biological process is this ge... | ceramide metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of lipids. Experimental data ... | |
medium_hidden_intermediate_10382 | Zika virus downregulates a specific gene, which in turn interacts with SKP1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.655 and an adjusted p-value of 0.00257. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10382","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with SKP1. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_10384 | Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of cell migration involved in sprouting angiogenesis. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of -3.162 and an adjusted p-value of 5.432e-06. Which protein is encoded by this gene? | Junctional cadherin 5-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10384","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of cell migration involved i... | |
medium_hidden_intermediate_10387 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CALM1. Evidence for one such gene reports a log2 fold change of -1.063 and an adjusted p-value of 9.363e-05. Which protein is encoded by that gene? | TBC1 domain family member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CALM1. Evidence for one such ... | |
medium_hidden_intermediate_10388 | Human betaherpesvirus 5 is reported to upregulate a specific gene, which in turn participates in disease pathology. Experimental evidence for this gene, derived from foreskin fibroblast cell lines, indicates a log2 fold change of approximately 1.406 and an adjusted p-value of 2.252e-05. Which protein is encoded by this... | Sialin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a specific gene, which in turn participates in disease pathology. Experime... | |
medium_hidden_intermediate_10390 | Hepacivirus C is reported to upregulate a gene that subsequently binds to SNRNP40. One such gene exhibits a log2 fold change of 1.515 and an adjusted p-value of 0.004339 in a specific study. Which protein is encoded by this gene? | U11/U12 small nuclear ribonucleoprotein 35 kDa protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently binds to SNRNP40. One such gene exhibits a log2 fold change... | |
medium_hidden_intermediate_10391 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in Regulated Necrosis. Evidence for this gene reports a log2 fold change of approximately 2.08 and an adjusted p-value of approximately 0.0057. Which protein is encoded by this gene? | Gasdermin-D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_10392 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables heme binding. Transcriptomic data for this gene in choroid plexus epithelium shows a log2 fold change of approximately -1.19 and an adjusted p-value of 0.007. Which protein is encoded by this gene? | Transmembrane reductase CYB561D2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables heme binding. Transcriptomic data fo... | |
medium_hidden_intermediate_10394 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Visual phototransduction. Experimental data for this gene reports a log2 fold change of 1.172 and an adjusted p-value of 0.01599. Which protein is encoded by this gene? | Low-density lipoprotein receptor-related protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10394","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Visual phototransduction.... | |
medium_hidden_intermediate_10395 | A gene is downregulated by Human gammaherpesvirus 8 and participates in Neutrophil degranulation. Experimental evidence for this gene reports a log2 fold change of -2.582 and an adjusted p-value of 0.0432. Which gene interacts with this entity? | DNAJC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in Neutrophil degranulation. Experimental evidence for ... | |
medium_hidden_intermediate_10396 | Pegivirus C is reported to downregulate a gene that participates in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. Evidence for this specific gene reports a log2 fold change of -1.443 and an adjusted p-value of 0.01495. In which cell type i... | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10396","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the biosynthesis of the N-glycan precursor (dolichol lip... | |
medium_hidden_intermediate_10399 | Cardiovirus A downregulates a specific gene that participates in the Generic Transcription Pathway. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122967) indicates that this gene has a log2 fold change of -1.306 and an adjusted p-value of 0.0119. Which disease is associated with this gene? | essential tremor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene that participates in the Generic Transcription Pathway. Experimental data from a... | |
medium_hidden_intermediate_10400 | Zika virus downregulates a specific gene, which in turn interacts with the histone protein H3C1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.28 and an adjusted p-value of approximately 0.0016. Which protein is encoded by this gene? | Lysine-rich nucleolar protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10400","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with the histone protein H3C1. Experimental data for this ... | |
medium_hidden_intermediate_10401 | Hepacivirus C is reported to downregulate a gene involved in cytoskeleton organization. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibited a log2 fold change of -1.384 and an adjusted p-value of 0.02119. Which protein is encoded by this specific gene? | Tubulin epsilon and delta complex protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene involved in cytoskeleton organization. In a study of peripheral blood monon... | |
medium_hidden_intermediate_10402 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with DYRK1B. One of these genes shows a log2 fold change of approximately 2.55 and an adjusted p-value of 0.000576 in a specific cell type. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10402","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with DYRK1B. One of these genes shows a log2 fold c... | |
medium_hidden_intermediate_10404 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate certain genes that participate in the Cell Cycle. One such gene exhibited a log2 fold change of 2.494 and an adjusted p-value of 0.0005254. Which gene interacts with this specific upregulated entity? | TRIM24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10404","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate certain genes that parti... | |
medium_hidden_intermediate_10405 | Pegivirus C is reported to downregulate a gene that is located in chromatin. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.306 and an adjusted p-value of 0.01314. Which protein is encoded by this specific gene? | Pogo transposable element with ZNF domain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in chromatin. In a study of peripheral blood mononuclear cell... | |
medium_hidden_intermediate_10406 | Two genes are structurally linked to Pegivirus C via downregulation and to gamma-tubulin binding via enabling. One of these genes exhibits a log2 fold change of -1.908 and an adjusted p-value of 0.004975 in peripheral blood mononuclear cells. Which disease is associated with this specific gene through genomic alteratio... | megalencephaly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10406","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to gamma-tubulin binding via enabling. One of these ... | |
medium_hidden_intermediate_10407 | Zika virus infection leads to the downregulation of certain genes that participate in the RHOQ GTPase cycle. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -2.50 and an adjusted p-value of 0.0018. Which protein is encoded by this specific gene? | Sodium bicarbonate cotransporter 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10407","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that participate in the RHOQ GTPase cycle. In a study of g... | |
medium_hidden_intermediate_10409 | Pegivirus C is reported to downregulate a gene that participates in SLC-mediated transport of organic anions. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.341 and an adjusted p-value of 0.009154. Which protein is encoded by this specific ge... | Monocarboxylate transporter 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10409","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in SLC-mediated transport of organic anions. In a study of ... | |
medium_hidden_intermediate_10412 | Hepacivirus C upregulates a gene that participates in factors involved in megakaryocyte development and platelet production. Evidence for one such gene reports a log2 fold change of 1.287 and an adjusted p-value of 0.02359. Which protein is encoded by that gene? | SH2B adapter protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10412","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in factors involved in megakaryocyte development and platelet production.... | |
medium_hidden_intermediate_10413 | Hepacivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription. Experimental evidence for this specific gene shows a log2 fold change of -1.107 and an adjusted p-value of 0.01594. Which protein is encoded by this gene? | Zinc finger protein 711 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10413","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription.... | |
medium_hidden_intermediate_10414 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the CDC42 GTPase cycle. One of these genes exhibits a log2 fold change of 1.754 and an adjusted p-value of 0.008344 in cardiomyocyte cell lines (study GSE151879). Which disease is associated with this specific gene as ... | congenital diaphragmatic hernia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10414","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the CDC42 GTPase cycle... | |
medium_hidden_intermediate_10415 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its product binds to CTNNB1. Experimental data for this gene in choroid plexus epithelium (study GSE157852) reports a log2 fold change of approximately -1.17 and an adjusted p-value of 0.0289. Which p... | Cadherin-22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its ... | |
medium_hidden_intermediate_10416 | In a study of Hepacivirus C infection, multiple genes are downregulated and their encoded proteins are located in the cytosol. One such gene exhibits a log2 fold change of -2.921 and an adjusted p-value of 0.00244. Which protein is encoded by this specific gene? | Bile acid-CoA:amino acid N-acyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection, multiple genes are downregulated and their encoded proteins are located in the cytoso... | |
medium_hidden_intermediate_10417 | Cardiovirus A is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibits a log2 fold change of -1.655 and an adjusted p-value of 0.01325. Which protein is encoded by this specific gene? | Serine/threonine-protein kinase tousled-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10417","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study of cervic... | |
medium_hidden_intermediate_10420 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in protein folding. One such gene exhibited a log2 fold change of approximately 1.24 and an adjusted p-value of 0.0001286. Which protein is encoded by this specific gene? | Phosducin-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10420","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that partici... | |
medium_hidden_intermediate_10421 | In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and interacts with YWHAE. This specific gene exhibits a log2 fold change of 5.189 and an adjusted p-value of 0.03433. Which biological process is this gene involved in? | signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10421","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and interacts with YWHAE. This specific gene ex... | |
medium_hidden_intermediate_10422 | Zika virus upregulates a gene that is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold change of 1.062 and an adjusted p-value of 0.008261. Which protein is encoded by this gene? | Heparan sulfate glucosamine 3-O-sulfotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold c... | |
medium_hidden_intermediate_10423 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to GNG5 via a 'binds' relationship. One of these genes has been reported in a study (GSE164073) with a log2 fold change of approximately 1.785 and an adjusted p-value of 0.007941. Which disea... | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_10424 | Human betaherpesvirus 5 is reported to upregulate a gene that participates in nucleosome assembly. In a specific study, this gene exhibited a log2 fold change of approximately 2.95 and an adjusted p-value of approximately 0.041. Which protein is encoded by this gene? | Histone H2B type 1-D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10424","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that participates in nucleosome assembly. In a specific study, this... | |
medium_hidden_intermediate_10426 | Zika virus downregulates a gene that is located in the mitochondrial inner membrane. Experimental data for this gene in glioma stem cells (study GSE114907) show a log2 fold change of -1.411 and an adjusted p-value of 0.0264. Which biological process is this gene involved in? | calcium export from the mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial inner membrane. Experimental data for this gene in glio... | |
medium_hidden_intermediate_10428 | Human betaherpesvirus 5 is known to downregulate a specific gene that is located at the site of DNA damage. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE132081) reports a log2 fold change of -1.169 and an adjusted p-value of 1.724e-05. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10428","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate a specific gene that is located at the site of DNA damage. Experimental dat... | |
medium_hidden_intermediate_10429 | Two genes are identified as markers of Regulatory T (Treg) cells and are both involved in the positive regulation of cell population proliferation. One of these genes exhibits a specific functional profile: its knockdown by siRNA decreased the proliferation of SKHep1 cells by approximately 50% (measured by BrdU uptake ... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10429","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers of Regulatory T (Treg) cells and are both involved in the positive regulation of cell po... | |
medium_hidden_intermediate_10430 | Human immunodeficiency virus 1 downregulates a gene that is located in the endoplasmic reticulum membrane. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.374 and an adjusted p-value of 0.002573. Which protein is encoded by this gene? | GEL complex subunit OPTI | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10430","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the endoplasmic reticulum membrane. In a study of mac... | |
medium_hidden_intermediate_10432 | In a study of foreskin fibroblast cell lines (GSE111036), Human betaherpesvirus 5 was found to downregulate a specific gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. This gene exhibited a log2 fold change of -1.481 and an adjusted p-value of 0.04313. What molecular function is e... | deoxyribose-phosphate aldolase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10432","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of foreskin fibroblast cell lines (GSE111036), Human betaherpesvirus 5 was found to downregulate a specific gene ... | |
medium_hidden_intermediate_10434 | Zika virus downregulates a gene that participates in developmental biology. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.090 and an adjusted p-value of 0.006143. Which protein is encoded by this gene? | Bifunctional glutamate/proline--tRNA ligase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10434","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in developmental biology. In a study of glioma stem cells (GSE114907), thi... | |
medium_hidden_intermediate_10435 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and is associated with ubiquitin protein ligase activity. This specific gene exhibits a log2 fold change of -1.894 and an adjusted p-value of 0.04748. Which protein is encoded by this gene? | RNA-binding E3 ubiquitin-protein ligase MEX3C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and is associated wit... | |
medium_hidden_intermediate_10436 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the activation of protein kinase activity. One of these genes exhibits a log2 fold change of -1.542 and an adjusted p-value of 0.0007514. Which protein is encoded by this specific gene? | Kinesin-like protein KIF14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the activation of p... | |
medium_hidden_intermediate_10437 | Two genes are structurally linked to Enterovirus A via an upregulation relationship and to non-classical monocytes via an enrichment relationship. One of these genes is associated with a log2 fold change of 1.010 and an adjusted p-value of 0.01975 in rhabdomyosarcoma cells. Which biological process is this specific gen... | negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10437","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via an upregulation relationship and to non-classical monocytes via an en... | |
medium_hidden_intermediate_10438 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for hepatocellular carcinoma. Experimental data for this gene in bronchial epithelial cell lines (study GSE153218) show a log2 fold change of approximately -1.152 and an adjusted p-value of 0.01821. Which disease ... | neural tube defects, susceptibility to | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for hepatocellula... | |
medium_hidden_intermediate_10439 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to amyotrophic lateral sclerosis via an upregulation relationship followed by a biomarker association. One of these genes is reported in a study (GSE157852) involving choroid plexus epithelium cells, with a log2 fold change of ... | Rho GTPase-activating protein 24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to amyotrophic lateral sclerosi... | |
medium_hidden_intermediate_10440 | Human alphaherpesvirus 1 upregulates a gene that is involved in signal transduction. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.012 and an adjusted p-value of 0.02079. Which protein is encoded by this gene? | Ciliary neurotrophic factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10440","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is involved in signal transduction. Experimental data for this gene in a mo... | |
medium_hidden_intermediate_10441 | Hepacivirus C downregulates a gene that subsequently interacts with RELA. Experimental data for this gene in hepatocytes (study GSE132606) reports a log2 fold change of approximately -1.28 and an adjusted p-value of approximately 9.79e-05. Which protein is encoded by this gene? | Homeobox protein MOX-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10441","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that subsequently interacts with RELA. Experimental data for this gene in hepatocytes (st... | |
medium_hidden_intermediate_10443 | Human polyomavirus 1 upregulates a gene that participates in the epigenetic regulation of gene expression. In a study of renal epithelial cells (GSE135833), this gene exhibited a log2 fold change of 1.782 and an adjusted p-value of 0.02755. Which protein is encoded by this gene? | Mediator of RNA polymerase II transcription subunit 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10443","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that participates in the epigenetic regulation of gene expression. In a study of ren... | |
medium_hidden_intermediate_10444 | Severe acute respiratory syndrome-related coronavirus upregulates a specific gene, which in turn participates in the process where SARS-CoV-2 activates or modulates innate and adaptive immune responses. Experimental data for this gene reports a log2 fold change of 5.685 and an adjusted p-value of 1.455e-05. Which prote... | Interferon alpha-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a specific gene, which in turn participates in the process... | |
medium_hidden_intermediate_10446 | A specific genomic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that is associated with breast carcinoma. Evidence regarding this gene includes the statement: 'We tested the effect of a novel adenosine A3 receptor agonist generically known as LJ-529 in breast cancer cells.' Which cell type... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific genomic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that is associated with breast... | |
medium_hidden_intermediate_10447 | Zika virus downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this gene reports a log2 fold change of -1.722 and an adjusted p-value of 0.009164. Which protein is encoded by this gene? | Large ribosomal subunit protein bL12m | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10447","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this gene reports a log2 f... | |
medium_hidden_intermediate_10448 | Measles morbillivirus upregulates a gene that is involved in the negative regulation of translation. Experimental data for this gene reports a log2 fold change of 2.418 and an adjusted p-value of 0.006657. Which protein is encoded by this gene? | Cytoplasmic polyadenylation element-binding protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10448","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the negative regulation of translation. Experimental data for t... | |
medium_hidden_intermediate_10449 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene that subsequently interacts with UNC93B1. This gene exhibits a log2 fold change of approximately 1.003 and an adjusted p-value of 0.002582. Which biological process is this gene involved in? | regulation of cilium assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10449","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene that subsequently interacts with... | |
medium_hidden_intermediate_10450 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables receptor ligand activity. Experimental data for this gene in a lung adenocarcinoma cell line shows a log2 fold change of approximately 1.37 and an adjusted p-value of approximately 0.025. Which protein is encoded by this gene? | Insulin-like growth factor-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables receptor ligand activity. Experimental... | |
medium_hidden_intermediate_10451 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to PLCG1. Experimental data for this gene reports a log2 fold change of approximately 2.257 and an adjusted p-value of 0.01636. Which protein is encoded by this gene? | Neurturin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10451","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to PLCG1. Experimental data for thi... | |
medium_hidden_intermediate_10453 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in ABC-family protein mediated transport. One such gene exhibits a log2 fold change of approximately 1.57 and an adjusted p-value of approximately 0.013. Which protein is encoded by this specific gene? | Multidrug resistance-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in ABC-family pro... | |
medium_hidden_intermediate_10454 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product enables protein phosphatase binding. This gene exhibits a log2 fold change of approximately 1.197 and an adjusted p-value of 0.02716. Which protein is encoded by this gene? | Protein phosphatase 1 regulatory subunit 3F | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10454","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_10455 | Zika virus downregulates a gene that enables RNA polymerase II transcription regulatory region sequence-specific DNA binding. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -4.368 and an adjusted p-value of 0.02169. Which protein is encoded by this gene? | Fos-related antigen 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10455","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables RNA polymerase II transcription regulatory region sequence-specific DNA binding... | |
medium_hidden_intermediate_10458 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for osteoporosis. This specific gene exhibits a log2 fold change of -2.658 and an adjusted p-value of 0.01387. Which protein is encoded by this gene? | Metallothionein-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10458","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_10459 | Pegivirus C downregulates a specific gene that participates in Class I MHC mediated antigen processing & presentation. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.696 and an adjusted p-value of 0.0004147. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10459","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that participates in Class I MHC mediated antigen processing & presentation. In a ... | |
medium_hidden_intermediate_10460 | Zika virus downregulates a gene that subsequently interacts with YWHAZ. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.094 and an adjusted p-value of 0.01705. Which protein is encoded by this specific gene? | PH and SEC7 domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10460","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that subsequently interacts with YWHAZ. In a study of glioma stem cells (GSE114907), one suc... | |
medium_hidden_intermediate_10461 | Zika virus downregulates a gene that is involved in intermembrane phospholipid transfer. Experimental data from glioma stem cells (study GSE114907) indicate that this specific gene has a log2 fold change of approximately -1.055 and an adjusted p-value of 0.01163. Which protein is encoded by this gene? | NADPH-dependent quinone oxidoreductase VAT1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10461","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in intermembrane phospholipid transfer. Experimental data from glioma stem ... | |
medium_hidden_intermediate_10462 | In a study of lung cells (GSE155241), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which is also associated with epilepsy. The expression data for this gene shows a log2 fold change of 1.242 and an adjusted p-value of 0.02928. Which cellular component is this gene locat... | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10462","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE155241), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specif... | |
medium_hidden_intermediate_10464 | Pegivirus C is reported to downregulate a gene that participates in MAPK1/MAPK3 signaling. Evidence for this gene in peripheral blood mononuclear cells shows a log2 fold change of -1.126 and an adjusted p-value of 0.0002685. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10464","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in MAPK1/MAPK3 signaling. Evidence for this gene in periphe... | |
medium_hidden_intermediate_10465 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with PTEN. This gene exhibited a log2 fold change of approximately 1.048 and an adjusted p-value of 0.0001459. Which protein is encoded by this gene? | Microtubule-associated serine/threonine-protein kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10465","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_10466 | Zika virus downregulates a gene that participates in the synthesis of phosphatidic acid (PA). Evidence for this gene reports a log2 fold change of -1.692 and an adjusted p-value of 0.009677. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the synthesis of phosphatidic acid (PA). Evidence for this gene reports... | |
medium_hidden_intermediate_10468 | In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is downregulated by Vaccinia virus and is enriched in non-classical monocytes. This gene exhibits a log2 fold change of -1.594 and an adjusted p-value of 0.01178. Which protein is encoded by this gene? | Tumor necrosis factor receptor superfamily member 19L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is downregulated by Vaccinia virus and is enric... | |
medium_hidden_intermediate_10470 | In a study of rhabdomyosarcoma cells, a gene upregulated by Enterovirus A and associated with adenoviridae infectious disease was found to have a log2 fold change of 2.523 and an adjusted p-value of 0.04541. Which protein is encoded by this gene? | T-lymphocyte activation antigen CD80 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10470","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells, a gene upregulated by Enterovirus A and associated with adenoviridae infectious diseas... | |
medium_hidden_intermediate_10474 | A gene serves as a marker for microglial cells and is enriched in eosinophils. Evidence for this gene includes a mean expression of 321.05 TPM, a z-score of 1.72, and a fold enrichment of 2.65. Which protein does this gene product interact with? | CDH1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for microglial cells and is enriched in eosinophils. Evidence for this gene includes a mean expres... | |
medium_hidden_intermediate_10475 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of endocytosis. Experimental data for this gene reports a log2 fold change of -1.094 and an adjusted p-value of 0.01468. Which protein is encoded by this gene? | Sorting nexin-12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10475","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of endocytosis... | |
medium_hidden_intermediate_10478 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in Class A/1 (Rhodopsin-like receptors). Evidence for this gene shows a log2 fold change of -5.171 and an adjusted p-value of 0.003922. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10478","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in Class A/1 (Rhodopsin-like receptors). Eviden... | |
medium_hidden_intermediate_10479 | A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the vesicle membrane. Experimental evidence for this gene reports a log2 fold change of -1.083 and an adjusted p-value of 0.004494. Which protein is encoded by this gene? | Ras-related protein Rab-21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the vesicle membrane. Experimental evidenc... | |
medium_hidden_intermediate_10480 | Pegivirus C is reported to downregulate a gene that enables enzyme-substrate adaptor activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.800 and an adjusted p-value of 0.0004123. Which protein is encoded by this specific gene? | Queuine tRNA-ribosyltransferase accessory subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10480","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables enzyme-substrate adaptor activity. In a study of peripheral bloo... | |
medium_hidden_intermediate_10481 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of cell migration. Evidence for one such gene reports a log2 fold change of 1.104 and an adjusted p-value of 0.006233. Which protein is encoded by that gene? | Zinc finger protein 304 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of cell... | |
medium_hidden_intermediate_10482 | Enterovirus A is reported to downregulate a gene that is located in the extracellular matrix. Evidence from a study on rhabdomyosarcoma cells indicates that one such gene has a log2 fold change of -3.274 and an adjusted p-value of 0.01884. Which cell type is this specific gene enriched in? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10482","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a gene that is located in the extracellular matrix. Evidence from a study on rhabd... | |
medium_hidden_intermediate_10483 | Pegivirus C is reported to downregulate a gene that is associated with lung carcinoma. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of approximately -1.134 and an adjusted p-value of 0.04455. Which protein is encoded by this specific gene? | BAR/IMD domain-containing adapter protein 2-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10483","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is associated with lung carcinoma. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_10485 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables phosphatase activity. Transcriptomic data for this gene in choroid plexus epithelium shows a log2 fold change of approximately 1.12 and an adjusted p-value of 1.67e-05. Which protein does this gene product interact with? | MAPK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables phosphatase activity. Transcriptomic d... | |
medium_hidden_intermediate_10487 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently interacts with GTF3C1. Experimental data for this intermediate gene reports a log2 fold change of 1.132 and an adjusted p-value of 0.006257. Which protein is encoded by this gene? | DNA-directed RNA polymerase I subunit RPA34 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10487","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently interacts with GTF3C1. Experiment... | |
medium_hidden_intermediate_10488 | Vaccinia virus upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this specific gene has a log2 fold change of approximately 1.79 and an adjusted p-value of 8.61e-05. Which disea... | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experim... | |
medium_hidden_intermediate_10489 | Vaccinia virus upregulates multiple genes that enable DNA-binding transcription repressor activity, RNA polymerase II-specific. One such gene exhibits a log2 fold change of 1.526 and an adjusted p-value of 0.001184 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this specific gene? | Zinc finger protein 140 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10489","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates multiple genes that enable DNA-binding transcription repressor activity, RNA polymerase II-specif... | |
medium_hidden_intermediate_10491 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response to starvation. Experimental data for this gene reports a log2 fold change of approximately 1.056 and an adjusted p-value of 0.0109. Which cellular component is this gene located in? | cytosolic large ribosomal subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response to ... | |
medium_hidden_intermediate_10492 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and located in the endoplasmic reticulum membrane. This specific gene exhibits a log2 fold change of -1.042 and an adjusted p-value of 0.008318. Which protein is encoded by this gene? | Vesicle-trafficking protein SEC22a | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and loca... | |
medium_hidden_intermediate_10494 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for male infertility. Experimental data for this gene reports a log2 fold change of 1.682 and an adjusted p-value of 0.02683. Which protein is encoded by this gene? | L-lactate dehydrogenase C chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for male infertilit... |
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