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medium_convergence_02414 | FGF2 and FGF4 both interact with a specific protein receptor. Experimental evidence for this interaction includes direct binding assays using radiolabeled acidic FGF (aFGF) or basic FGF (bFGF), competition inhibition by native growth factors, and Scatchard analysis demonstrating that the proteins flg and a related rece... | Fibroblast growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_02414","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF2 and FGF4 both interact with a specific protein receptor. Experimental evidence for this interaction includes direct binding assays using radiolabeled ac... | |
medium_convergence_02415 | PPP2CA and PPP2R5C share multiple interacting partners. One such shared partner is described in evidence stating: 'We determined that [this shared partner] and its homolog cyclin G1 directly interact with the catalytic subunit of protein phosphatase 2A (PP2A).' Which disease is associated with this specific shared enti... | thyroid tumor | Medium | convergence | {"qa_id":"medium_convergence_02415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2R5C share multiple interacting partners. One such shared partner is described in evidence stating: 'We determined that [this shared partner] a... | |
medium_convergence_02416 | Carbamazepine and Methylphenobarbital both interact with a specific drug. Evidence indicates that the bioavailability of this drug is markedly reduced when administered jointly with antiepileptics or corticosteroids, specifically phenytoin or dexamethasone. Which disease is this drug indicated for? | schistosomiasis | Medium | convergence | {"qa_id":"medium_convergence_02416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Carbamazepine and Methylphenobarbital both interact with a specific drug. Evidence indicates that the bioavailability of this drug is markedly reduced when a... | |
medium_convergence_02418 | GAB1 and PDLIM7 both interact with a specific protein. Evidence indicates that Enigma interacts in intact cells with the short isoform of this protein (wild-type) and its pathologic mutants associated with MEN2 syndromes, specifically the C634R and M918T variants. Which protein is encoded by the gene corresponding to t... | Proto-oncogene tyrosine-protein kinase receptor Ret | Medium | convergence | {"qa_id":"medium_convergence_02418","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAB1 and PDLIM7 both interact with a specific protein. Evidence indicates that Enigma interacts in intact cells with the short isoform of this protein (wild-... | |
medium_convergence_02419 | HSP90AA1 and CD14 both interact with a shared protein. Evidence indicates that this shared protein is a client of Hsp90 in vivo. Which protein product is encoded by this shared gene? | Serine/threonine-protein kinase TBK1 | Medium | convergence | {"qa_id":"medium_convergence_02419","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and CD14 both interact with a shared protein. Evidence indicates that this shared protein is a client of Hsp90 in vivo. Which protein product is enc... | |
medium_convergence_02420 | PPP2CB and PPP2R1B both interact with a shared protein entity. Evidence regarding this entity states: 'Specifically, the alpha isoform, B56beta, and B56epsilon complexed with the protein phosphatase 2A A and C subunits localize to the cytoplasm, whereas B56delta, B56gamma1, and B56gamma3 are concentrated in the nucleus... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_02420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CB and PPP2R1B both interact with a shared protein entity. Evidence regarding this entity states: 'Specifically, the alpha isoform, B56beta, and B56epsil... | |
medium_convergence_02421 | FANCI and BRCA1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to BRCA1, a finding established using bacterially expressed fragments of the respective proteins. Which protein is encoded by the gene corresponding to this shared partner? | Partner and localizer of BRCA2 | Medium | convergence | {"qa_id":"medium_convergence_02421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCI and BRCA1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to BRCA1, a finding esta... | |
medium_convergence_02422 | Morphine and Trimethobenzamide share a common interacting drug. Evidence regarding this shared entity states that the analgesic activities of morphine and/or aminopyrine were potentiated by pretreatment with sleep-inducers, but not by 450191-S. Which disease is this entity indicated for? | insomnia | Medium | convergence | {"qa_id":"medium_convergence_02422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Trimethobenzamide share a common interacting drug. Evidence regarding this shared entity states that the analgesic activities of morphine and/or... | |
medium_convergence_02423 | CRY2 and CLOCK each interact with more than one shared protein. Evidence concerning one such shared entity reports that CRY1 or CRY2 (or both) showed light-independent interactions with CLOCK and BMAL1, as well as with PER1, this shared protein, and TIM. Which protein is encoded by that entity? | Period circadian protein homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_02423","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY2 and CLOCK each interact with more than one shared protein. Evidence concerning one such shared entity reports that CRY1 or CRY2 (or both) showed light-i... | |
medium_convergence_02424 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of -1.745 and an adjusted p-value of 0.0003101. Which protein is encoded by this gene? | Ribosome biogenesis protein NOP53 | Medium | convergence | {"qa_id":"medium_convergence_02424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates tha... | |
medium_convergence_02425 | STRN4 and STK26 both interact with a shared protein complex component. Evidence indicates that the STRIPAK complex contains the PP2A catalytic (PP2Ac) and scaffolding (PP2A A) subunits, the striatins (PP2A regulatory B''' subunits), the striatin-associated protein Mob3, the novel proteins STRIP1 and STRIP2 (formerly FA... | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | Medium | convergence | {"qa_id":"medium_convergence_02425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRN4 and STK26 both interact with a shared protein complex component. Evidence indicates that the STRIPAK complex contains the PP2A catalytic (PP2Ac) and sc... | |
medium_convergence_02427 | Measles morbillivirus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of 2.602 and an adjusted p-value of 0.04408. Which disease is associated with this gene through genomic alterations? | polycystic ovary syndrome | Medium | convergence | {"qa_id":"medium_convergence_02427","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of 2.602 and an... | |
medium_convergence_02428 | SMAD3 and PTK2 both interact with a shared protein. Evidence regarding this shared protein indicates that co-immunoprecipitation studies in HEK293 cells demonstrate an interaction between a TGF-beta-induced transcript 1 protein and either CA-Smad3 or wild-type Smad3. This interaction occurs through the MH2 domain of Sm... | Transforming growth factor beta-1-induced transcript 1 protein | Medium | convergence | {"qa_id":"medium_convergence_02428","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and PTK2 both interact with a shared protein. Evidence regarding this shared protein indicates that co-immunoprecipitation studies in HEK293 cells demo... | |
medium_convergence_02429 | GSK3B and JUN share a common interacting partner. Evidence indicates that an anti-HA antibody co-precipitated c-Jun from HeLa cells co-expressing c-Jun and HA-tagged versions of this shared partner, supporting the idea that this partner directly associates with AP-1 in vivo. Which cell type is this shared partner enric... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and JUN share a common interacting partner. Evidence indicates that an anti-HA antibody co-precipitated c-Jun from HeLa cells co-expressing c-Jun and H... | |
medium_convergence_02430 | GNG5 and ARRB2 both interact with a shared protein. Experimental evidence indicates that the carboxyl terminus and the third intracellular loop of the delta opioid receptor (DOR) are sufficient for binding to beta-arrestin 1 and 2. Which disease is associated with this shared protein? | common cold | Medium | convergence | {"qa_id":"medium_convergence_02430","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNG5 and ARRB2 both interact with a shared protein. Experimental evidence indicates that the carboxyl terminus and the third intracellular loop of the delta ... | |
medium_convergence_02431 | CHEK2 and PLK1 both interact with a specific shared protein. Evidence indicates that the in vivo phosphorylation of this shared protein is abrogated by a Chk2 inhibitor, and a physical interaction between Chk2 and this protein has been observed, confirming that Chk2 is responsible for its phosphorylation upon DNA damag... | Mediator of RNA polymerase II transcription subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_02431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and PLK1 both interact with a specific shared protein. Evidence indicates that the in vivo phosphorylation of this shared protein is abrogated by a Chk... | |
medium_convergence_02432 | SMG1 and ATM share interaction partners. One such shared partner is reported to interact with and stabilize all six members of the PIKK family of proteins (mTOR, the partner itself, ATR, DNA-PKcs, SMG-1, and TRRAP). Which protein is encoded by the gene corresponding to this shared partner? | TELO2-interacting protein 1 homolog | Medium | convergence | {"qa_id":"medium_convergence_02432","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and ATM share interaction partners. One such shared partner is reported to interact with and stabilize all six members of the PIKK family of proteins (m... | |
medium_convergence_02433 | GABARAP and MAP1LC3C both interact with a specific shared protein. Evidence indicates that this shared protein binds to ATG8-family proteins with higher affinity than p62. Which protein is encoded by the gene corresponding to this shared entity? | Tumor protein p53-inducible nuclear protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02433","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABARAP and MAP1LC3C both interact with a specific shared protein. Evidence indicates that this shared protein binds to ATG8-family proteins with higher affi... | |
medium_convergence_02434 | FLII and STK4 share a common interacting partner. Evidence indicates that Fli-I binds directly to BAF53, an actin-related component of the SWI/SNF complex, suggesting that Fli-I may recruit SWI/SNF to ER target genes via this interaction. Which protein is encoded by the gene corresponding to this shared interacting par... | Actin-like protein 6A | Medium | convergence | {"qa_id":"medium_convergence_02434","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLII and STK4 share a common interacting partner. Evidence indicates that Fli-I binds directly to BAF53, an actin-related component of the SWI/SNF complex, s... | |
medium_convergence_02436 | Human betaherpesvirus 5 and West Nile virus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of 5.791 and an adjusted p-value of 0.007919. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02436","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and West Nile virus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of 5.791... | |
medium_convergence_02437 | RFC5 and RPA1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it interacted with replication protein A (RPA) and RPA-coated DNA, and that RPA promoted the loading of this entity onto RPA-free DNA. Which protein is encoded by the gene corresponding to that entity? | TIMELESS-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_02437","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RFC5 and RPA1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it interacted with replication protein A (R... | |
medium_convergence_02438 | AGR2 and MTOR share common interaction partners. One such shared partner is reported to interact with a protein disulfide isomerase family member in different mammalian cells. Which protein is encoded by this shared partner? | Protein disulfide-isomerase A3 | Medium | convergence | {"qa_id":"medium_convergence_02438","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGR2 and MTOR share common interaction partners. One such shared partner is reported to interact with a protein disulfide isomerase family member in differen... | |
medium_convergence_02439 | MYC and PCNA share interaction partners. One such shared partner is a novel 150 kDa protein designated PARP-10, which has been reported to interact with MYC. Which protein is encoded by the gene corresponding to this shared partner? | Protein mono-ADP-ribosyltransferase PARP10 | Medium | convergence | {"qa_id":"medium_convergence_02439","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PCNA share interaction partners. One such shared partner is a novel 150 kDa protein designated PARP-10, which has been reported to interact with MYC.... | |
medium_convergence_02440 | DCLRE1C and NHEJ1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we report that Artemis forms a complex with the 469 kDa DNA-dependent protein kinase (the shared protein) in the absence of DNA.' Which protein is connected to that entity through the 'encode... | DNA-dependent protein kinase catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_02440","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCLRE1C and NHEJ1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we report that Artemis forms... | |
medium_convergence_02441 | HSP90AA1 and PCM1 both interact with a shared protein. Evidence regarding this shared protein indicates that it regulates chaperone function by reducing Hsp90 ATPase activity while fostering Hsp90 association with kinase clients, including a specific kinase. Which protein is encoded by this shared entity? | Dual specificity protein kinase TTK | Medium | convergence | {"qa_id":"medium_convergence_02441","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and PCM1 both interact with a shared protein. Evidence regarding this shared protein indicates that it regulates chaperone function by reducing Hsp9... | |
medium_convergence_02442 | TGFB3 and CAV1 both interact with a shared protein. Evidence indicates that Caveolin-1 interacts with the Type I TGF-beta receptor. Which disease is associated with this shared protein as a biomarker? | systemic sclerosis | Medium | convergence | {"qa_id":"medium_convergence_02442","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TGFB3 and CAV1 both interact with a shared protein. Evidence indicates that Caveolin-1 interacts with the Type I TGF-beta receptor. Which disease is associat... | |
medium_convergence_02443 | Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 1.246 and an adjusted p-value of 0.02361. Which disease is associated with this gene as a biomarker? | glioma | Medium | convergence | {"qa_id":"medium_convergence_02443","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports ... | |
medium_convergence_02445 | DBF4 and MCM4 both interact with a shared protein partner. Evidence regarding one such partner states: 'We also identified an interaction between MCM-BP and the Dbf4 regulatory component of the DDK kinase in both yeast 2-hybrid and insect cell co-expression assays, and this interaction was verified by co-immunoprecipit... | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_02445","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and MCM4 both interact with a shared protein partner. Evidence regarding one such partner states: 'We also identified an interaction between MCM-BP and ... | |
medium_convergence_02446 | Pegaspargase and Alemtuzumab both interact with a specific shared drug. Clinical evidence indicates that this shared drug, when combined with Alemtuzumab (a humanized monoclonal antibody targeting CD52), resulted in an adequate overall response rate in patients with aplastic anemia (AA). What disease is this shared dru... | graft versus host disease | Medium | convergence | {"qa_id":"medium_convergence_02446","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Alemtuzumab both interact with a specific shared drug. Clinical evidence indicates that this shared drug, when combined with Alemtuzumab (a ... | |
medium_convergence_02448 | Atenolol and Carteolol both interact with a specific shared drug. Evidence regarding this shared entity states: 'The selective beta-blocker atenolol showed a tendency to improve the FBF response to MCh (from 28.8 +/- 9.2 to 32.6 +/- 8.7 ml/min/ml tissue, p < 0.05).' Which drug is connected to this shared entity through... | Amifampridine | Medium | convergence | {"qa_id":"medium_convergence_02448","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Atenolol and Carteolol both interact with a specific shared drug. Evidence regarding this shared entity states: 'The selective beta-blocker atenolol showed a... | |
medium_convergence_02450 | Both Human orthopneumovirus and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.57 and an adjusted p-value of 0.0447. Which protein is encoded by this gene? | UL16-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02450","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in cytotoxic T-lymphoc... | |
medium_convergence_02452 | HSPD1 and IRF7 both interact with a shared protein. Evidence regarding this shared protein states: 'The death domain of this protein interacted with an inhibitory domain of IRF7, and this interaction resulted in activation of the IFN-alpha-dependent promoters.' Which cell type is this shared protein enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_02452","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPD1 and IRF7 both interact with a shared protein. Evidence regarding this shared protein states: 'The death domain of this protein interacted with an inhib... | |
medium_convergence_02453 | CEP164 and ATR share multiple binding partners. One such shared partner is a protein kinase that has been shown to phosphorylate specific sites on both CEP164 and ATR in vitro. Which disease is associated with this shared partner through genomic alterations? | candidiasis | Medium | convergence | {"qa_id":"medium_convergence_02453","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEP164 and ATR share multiple binding partners. One such shared partner is a protein kinase that has been shown to phosphorylate specific sites on both CEP16... | |
medium_convergence_02454 | Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in natural killer cells, sourced from study GSE125686, reports a log2 fold change of approximately 1.19 and an adjusted p-value of 0.034. Which protein does this gene product in... | UBE2I | Medium | convergence | {"qa_id":"medium_convergence_02454","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in natural kil... | |
medium_convergence_02455 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) show a log2 fold change of approximately 1.117 and an adjusted p-value of 0.04756. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase Itchy homolog | Medium | convergence | {"qa_id":"medium_convergence_02455","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific gene. Experimental data for this gene i... | |
medium_convergence_02456 | CHEK1 and BLM both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following replication stress or other types of DNA damage. Which disease is associated with this protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_02456","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and BLM both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following repl... | |
medium_convergence_02457 | VPS28 and MVB12B each interact with more than one shared protein. Evidence concerning one shared entity reports that ESCRT-II binds to the ESCRT-I VPS28 C-terminal domain subunit through a helix immediately C-terminal to the GLUE domain of this shared protein. Which protein is encoded by that entity? | Vacuolar protein-sorting-associated protein 36 | Medium | convergence | {"qa_id":"medium_convergence_02457","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS28 and MVB12B each interact with more than one shared protein. Evidence concerning one shared entity reports that ESCRT-II binds to the ESCRT-I VPS28 C-te... | |
medium_convergence_02458 | CENPA and CENPL both interact with a shared protein complex component. Evidence indicates that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (a specific centromere protein, CENP-N and CENP-T), along with CENP-U, CENP-C and CENP... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02458","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPL both interact with a shared protein complex component. Evidence indicates that CENP-A nucleosomes directly recruit a proximal CENP-A nucleoso... | |
medium_convergence_02459 | ESR1 and SIN3A share multiple interacting partners. One such shared partner is supported by evidence showing that a protein encoded by PA2G4 interacts with it both in vitro and in vivo, as demonstrated by glutathione S-transferase (GST) pull-down and coimmunoprecipitation analysis. Which protein is encoded by this shar... | Proliferation-associated protein 2G4 | Medium | convergence | {"qa_id":"medium_convergence_02459","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and SIN3A share multiple interacting partners. One such shared partner is supported by evidence showing that a protein encoded by PA2G4 interacts with i... | |
medium_convergence_02460 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. In a study of melanoma cell lines (GSE136586), the expression of this gene showed a log2 fold change of approximately -1.215 and an adjusted p-value of 0.001776. What molecular func... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02460","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. In a study of mela... | |
medium_convergence_02461 | AP2B1 and CNOT1 share a common interacting partner. Evidence indicates that this shared entity is an RNA-binding ubiquitin E3 ligase, specifically noting that variants of this ligase interact with adaptor-related protein complex 2 (AP-2), a cargo adaptor in clathrin-mediated endocytosis. Which disease is associated wit... | autoimmune disorder of the nervous system | Medium | convergence | {"qa_id":"medium_convergence_02461","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2B1 and CNOT1 share a common interacting partner. Evidence indicates that this shared entity is an RNA-binding ubiquitin E3 ligase, specifically noting tha... | |
medium_convergence_02462 | DNAAF10 and POLR2H share multiple interacting partners. One such shared partner was identified as a binding protein of Monad through affinity purification and mass spectrometry. What molecular function is enabled by this specific shared partner? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02462","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAAF10 and POLR2H share multiple interacting partners. One such shared partner was identified as a binding protein of Monad through affinity purification an... | |
medium_convergence_02463 | IL12RB1 and JAK1 both interact with a common protein. Evidence regarding this shared partner states: 'The kinase inhibitory region of this protein targets the substrate binding groove of JAK with high specificity and thereby blocks any subsequent phosphorylation.' Which protein is encoded by the gene corresponding to t... | Suppressor of cytokine signaling 1 | Medium | convergence | {"qa_id":"medium_convergence_02463","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL12RB1 and JAK1 both interact with a common protein. Evidence regarding this shared partner states: 'The kinase inhibitory region of this protein targets th... | |
medium_convergence_02464 | EZH2 and ZRANB1 share a common interacting partner. Evidence indicates that this shared partner is an E3 ligase that triggers K63-linked polyubiquitination of EZH2 in extranodal NK/T-cell lymphoma (ENKTL) and unexpectedly stabilizes EZH2. Which protein encodes this shared interacting partner? | E3 ubiquitin-protein ligase TRIP12 | Medium | convergence | {"qa_id":"medium_convergence_02464","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and ZRANB1 share a common interacting partner. Evidence indicates that this shared partner is an E3 ligase that triggers K63-linked polyubiquitination o... | |
medium_convergence_02465 | GNA15 and GNB3 both interact with a specific gamma subunit. Experimental evidence involving co-immunoprecipitation and bioluminescence resonance energy transfer (BRET) indicates that a splice variant of GNB3 (Gβ3s) fails to form complexes with Gγ or Gα subunits, unlike the canonical Gβ3. Which protein encodes the gamma... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | Medium | convergence | {"qa_id":"medium_convergence_02465","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA15 and GNB3 both interact with a specific gamma subunit. Experimental evidence involving co-immunoprecipitation and bioluminescence resonance energy trans... | |
medium_convergence_02466 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.63 and an adjusted p-value of approximately 0.0155. Which cell type is this gene enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_02466","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE... | |
medium_convergence_02467 | BMP8A and INHBA both interact with a shared receptor. Evidence regarding one such shared entity states: 'We hypothesized that, in addition to its canonical receptor [receptor], activin A might similarly bind and signal via BMPR2.' Which disease is associated with this specific entity through genomic alterations? | malignant colon neoplasm | Medium | convergence | {"qa_id":"medium_convergence_02467","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP8A and INHBA both interact with a shared receptor. Evidence regarding one such shared entity states: 'We hypothesized that, in addition to its canonical r... | |
medium_convergence_02469 | CNTN1 and DLL1 both interact with a specific receptor protein. Experimental evidence indicates that three DSL family proteins bind to this endogenous receptor on the surface of BaF3 cells, although the binding characteristics of Jagged2 to this receptor differ from those of Delta1 and Jagged1. Which protein is encoded ... | Neurogenic locus notch homolog protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02469","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNTN1 and DLL1 both interact with a specific receptor protein. Experimental evidence indicates that three DSL family proteins bind to this endogenous recepto... | |
medium_convergence_02470 | CRYAB and HNRNPD both interact with a specific shared gene product. Evidence indicates that the RNA-binding proteins AUF1 and HuR bind to the AU-rich element (ARE) of the mRNA transcribed from this shared entity. Which protein is encoded by this shared gene? | Vascular endothelial growth factor A, long form | Medium | convergence | {"qa_id":"medium_convergence_02470","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRYAB and HNRNPD both interact with a specific shared gene product. Evidence indicates that the RNA-binding proteins AUF1 and HuR bind to the AU-rich element... | |
medium_convergence_02471 | RPS27A and UBC each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that NMR chemical shift perturbation and paramagnetic relaxation enhancement approaches were employed to characterize the binding interaction between this partner and ubiquitin, Lys-48-linked... | Ubiquitin-conjugating enzyme E2 G2 | Medium | convergence | {"qa_id":"medium_convergence_02471","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPS27A and UBC each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that NMR chemical shift pert... | |
medium_convergence_02472 | HDAC1 and TCF12 share a common interaction partner. Contextual evidence indicates that among eight histone deacetylases tested, only the class I HDACs (HDAC-1, HDAC-2, and HDAC-3) bind to this partner. Which protein is encoded by this shared interaction partner? | Protein CBFA2T1 | Medium | convergence | {"qa_id":"medium_convergence_02472","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and TCF12 share a common interaction partner. Contextual evidence indicates that among eight histone deacetylases tested, only the class I HDACs (HDAC-... | |
medium_convergence_02473 | BMI1 and CBX4 share multiple protein interaction partners. One such shared partner is reported to coimmunoprecipitate and cofractionate with a protein encoded by the gene corresponding to this shared partner. Which protein is encoded by the gene corresponding to this shared partner? | Polyhomeotic-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02473","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and CBX4 share multiple protein interaction partners. One such shared partner is reported to coimmunoprecipitate and cofractionate with a protein encode... | |
medium_convergence_02474 | CBX3 and LMNA share a common interacting partner. Experimental evidence for this interaction includes a yeast two-hybrid assay and an in vitro binding assay demonstrating that the human LR domain binds to heterochromatin protein 1 (HP1), a well-characterized mediator of heterochromatin formation. Which protein is encod... | Proliferation marker protein Ki-67 | Medium | convergence | {"qa_id":"medium_convergence_02474","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and LMNA share a common interacting partner. Experimental evidence for this interaction includes a yeast two-hybrid assay and an in vitro binding assay ... | |
medium_convergence_02476 | CREBBP and EP300 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'A physical interaction between a Kruppel-like factor and CBP was demonstrated by glutathione-S-transferase pull-down and by in vivo co-immuno-precipitation experiments.' Which protein is connected to t... | Krueppel-like factor 4 | Medium | convergence | {"qa_id":"medium_convergence_02476","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EP300 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'A physical interaction between a Krupp... | |
medium_convergence_02477 | ALK and KRAS both interact with a shared protein. Evidence indicates that endogenous levels of this shared protein and ALK interact in neuroblastoma (NB) cells, and this specific interaction is abrogated upon treatment with the ALK inhibitor lorlatinib. Which protein is encoded by the gene corresponding to this shared ... | Amino acid transporter heavy chain SLC3A2 | Medium | convergence | {"qa_id":"medium_convergence_02477","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and KRAS both interact with a shared protein. Evidence indicates that endogenous levels of this shared protein and ALK interact in neuroblastoma (NB) cel... | |
medium_convergence_02478 | SYK and TGFB1 are both involved in more than one shared biological process. One of these shared processes is linked to experimental evidence stating: 'In fact, a consistent decrease in superoxide anion, but not nitric oxide production, was manifested when the Syk pathway was inhibited.' Which biological process is conn... | superoxide anion generation | Medium | convergence | {"qa_id":"medium_convergence_02478","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SYK and TGFB1 are both involved in more than one shared biological process. One of these shared processes is linked to experimental evidence stating: 'In fac... | |
medium_convergence_02479 | ANAPC11 and ANAPC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Both APC11 and UbcH10 bind to the C-terminal cullin homology domain of this partner, whereas Ubc4 interacts with APC11 directly.' Which cellular component is this shared partner located in? | anaphase-promoting complex | Medium | convergence | {"qa_id":"medium_convergence_02479","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC11 and ANAPC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Both APC11 and UbcH10 bind t... | |
medium_convergence_02480 | INCENP and AURKB each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Aurora B directly binds to the substrate-recognition domain of this entity in vitro, and that the entity coimmunoprecipitates with the Cul3 complex during mitosis. Which protein is enc... | Kelch-like protein 13 | Medium | convergence | {"qa_id":"medium_convergence_02480","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"INCENP and AURKB each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Aurora B directly bin... | |
medium_convergence_02481 | HMGB1 and IRAK1 both interact with a shared protein. Evidence indicates that endogenous IRAK-4 interacts with IRAK-1 and TRAF6 in an IL-1-dependent manner. Which protein is encoded by the gene corresponding to this shared entity? | Interleukin-1 receptor-associated kinase 4 | Medium | convergence | {"qa_id":"medium_convergence_02481","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HMGB1 and IRAK1 both interact with a shared protein. Evidence indicates that endogenous IRAK-4 interacts with IRAK-1 and TRAF6 in an IL-1-dependent manner. W... | |
medium_convergence_02483 | HRAS and PPP1CC both interact with a common protein. Experimental evidence indicates that this shared protein associates with active Ras, but does not associate with inactive Ras or Raf. Which protein is encoded by the gene corresponding to this shared interaction partner? | Erbin | Medium | convergence | {"qa_id":"medium_convergence_02483","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and PPP1CC both interact with a common protein. Experimental evidence indicates that this shared protein associates with active Ras, but does not associ... | |
medium_convergence_02484 | ATG7 and ATG4B both interact with a specific shared protein. Experimental evidence indicates that a member of the ATG8 family forms an E1-substrate intermediate with this protein (specifically the C572S mutant) and an E2-substrate intermediate with Atg3 (C264S). Which protein is encoded by the gene corresponding to thi... | Gamma-aminobutyric acid receptor-associated protein-like 1 | Medium | convergence | {"qa_id":"medium_convergence_02484","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG7 and ATG4B both interact with a specific shared protein. Experimental evidence indicates that a member of the ATG8 family forms an E1-substrate intermedi... | |
medium_convergence_02485 | EIF3E and EIF3A both interact with a shared protein partner. Experimental evidence indicates that a monoclonal antibody against eIF3a (p170) co-immunoprecipitates this specific partner along with the eIF3 complex. Which protein is encoded by the gene corresponding to this shared partner? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_02485","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3E and EIF3A both interact with a shared protein partner. Experimental evidence indicates that a monoclonal antibody against eIF3a (p170) co-immunoprecipi... | |
medium_convergence_02486 | Rift Valley fever phlebovirus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of 1.437 and an adjusted p-value of 0.01211. Which protein is encoded by this gene? | Ubiquitin/ISG15-conjugating enzyme E2 L6 | Medium | convergence | {"qa_id":"medium_convergence_02486","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a lo... | |
medium_convergence_02487 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately 1.72 and an adjusted p-value of ap... | Homeobox protein TGIF1 | Medium | convergence | {"qa_id":"medium_convergence_02487","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_02488 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117) shows a log2 fold change of -1.649 and an adjusted p-value of 0.000522. Which disease is associated with this gene? | galactosemia 4 | Medium | convergence | {"qa_id":"medium_convergence_02488","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117... | |
medium_convergence_02489 | CBL and CD3G both interact with a specific protein. Evidence indicates that a Src-like adapter protein interacts with this protein in vivo in a phosphorylation-independent manner. Which protein is encoded by the gene corresponding to this interaction partner? | Src-like-adapter 2 | Medium | convergence | {"qa_id":"medium_convergence_02489","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBL and CD3G both interact with a specific protein. Evidence indicates that a Src-like adapter protein interacts with this protein in vivo in a phosphorylati... | |
medium_convergence_02490 | CHD4 and HSP90AA1 share multiple interacting partners. One such partner is implicated in a study demonstrating that in human melanoma cells, two isoforms of a cyclin-dependent kinase interact with Hsp90 and its co-chaperone cdc37. Which protein is encoded by this shared interacting partner? | Cyclin-dependent kinase 11B | Medium | convergence | {"qa_id":"medium_convergence_02490","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and HSP90AA1 share multiple interacting partners. One such partner is implicated in a study demonstrating that in human melanoma cells, two isoforms of ... | |
medium_convergence_02492 | Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 2.57 and an adjusted p-value of approximately 3.84e-06. Which disease is associated with this gene? | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_02492","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE112... | |
medium_convergence_02493 | GDF6 and BMPR1B both interact with a common protein partner. Evidence indicates this partner is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which protein is encoded by the gene corresponding to this partne... | Bone morphogenetic protein receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_02493","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GDF6 and BMPR1B both interact with a common protein partner. Evidence indicates this partner is a transmembrane serine/threonine kinase that binds BMP-2 and ... | |
medium_convergence_02494 | NTRK1 and NUMB both interact with a specific protein kinase. Evidence regarding this shared partner states: 'Here, we identify in vivo phosphorylation sites of mammalian Numb and show that both mammalian and Drosophila Numb interact with, and are substrates for aPKC in vitro.' Which protein is encoded by the gene corre... | Protein kinase C zeta type | Medium | convergence | {"qa_id":"medium_convergence_02494","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NTRK1 and NUMB both interact with a specific protein kinase. Evidence regarding this shared partner states: 'Here, we identify in vivo phosphorylation sites ... | |
medium_convergence_02495 | GTF2B and IKBKE each interact with more than one shared transcription factor. Evidence concerning one shared entity reports: 'Furthermore, NS7a interacts simultaneously with the kinase domain (KD) and the scaffold dimerization domain (SDD) of IKKε, competing with TRAF3, and this transcription factor for binding to IKKε... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_02495","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2B and IKBKE each interact with more than one shared transcription factor. Evidence concerning one shared entity reports: 'Furthermore, NS7a interacts sim... | |
medium_convergence_02496 | ARRB2 and MDM2 share a common interacting partner. Evidence regarding this shared partner states: 'Truncation analyses indicate that two sites in beta-arrestin 2 are involved in mediating its interaction with the shared partner, one associated with its extreme amino-terminal region and the other located within the carb... | 3',5'-cyclic-AMP phosphodiesterase 4D | Medium | convergence | {"qa_id":"medium_convergence_02496","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB2 and MDM2 share a common interacting partner. Evidence regarding this shared partner states: 'Truncation analyses indicate that two sites in beta-arrest... | |
medium_convergence_02497 | EP300 and RICTOR both interact with a specific protein. Evidence indicates that the phosphorylated form of this protein (specifically at threonine 638) interacts with the p300-HIF1α complex in the nuclei of hypoxic glomerular endothelial cells, and this phosphorylation enhances the transcriptional activity of HIF1α. Wh... | Protein kinase C alpha type | Medium | convergence | {"qa_id":"medium_convergence_02497","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RICTOR both interact with a specific protein. Evidence indicates that the phosphorylated form of this protein (specifically at threonine 638) inter... | |
medium_convergence_02498 | Cyclosporine and Ketoconazole both interact with a specific drug. Clinical evidence regarding this drug describes a study where 10 patients with castration-resistant prostate cancer (CRPC), who had progressed after treatment with ketoconazole, were treated with a combination of ketoconazole plus this drug at a dose of ... | benign prostatic hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_02498","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Ketoconazole both interact with a specific drug. Clinical evidence regarding this drug describes a study where 10 patients with castration-r... | |
medium_convergence_02499 | CDC7 and CDC6 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A novel human protein, [shared partner], was identified on the basis of its ability to bind to human Cdc7-related kinase (huCdc7).' Which protein is connected to that entity through the 'encodes' relat... | Protein DBF4 homolog A | Medium | convergence | {"qa_id":"medium_convergence_02499","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC7 and CDC6 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A novel human protein, [shared partner... | |
medium_convergence_02500 | Urokinase and Tenecteplase both interact with a specific shared drug. Clinical evidence regarding this shared drug describes a study where 96 patients with acute cerebral infarction (ACI) without clear culprit vessels were randomized into a control group receiving urokinase and an observation group receiving urokinase ... | acute coronary syndrome | Medium | convergence | {"qa_id":"medium_convergence_02500","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Urokinase and Tenecteplase both interact with a specific shared drug. Clinical evidence regarding this shared drug describes a study where 96 patients with a... | |
medium_convergence_02501 | Both INHBA and NODAL interact with a specific receptor protein. One piece of evidence regarding this receptor states: 'We hypothesized that, in addition to its canonical receptor [REDACTED], activin A might similarly bind and signal via BMPR2.' Which protein is encoded by the gene corresponding to this receptor? | Activin receptor type-2A | Medium | convergence | {"qa_id":"medium_convergence_02501","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both INHBA and NODAL interact with a specific receptor protein. One piece of evidence regarding this receptor states: 'We hypothesized that, in addition to i... | |
medium_convergence_02502 | Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.30 and an adjusted p-value of 0.00678. Which protein does this gene product interact with? | GSK3B | Medium | convergence | {"qa_id":"medium_convergence_02502","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a ... | |
medium_convergence_02504 | Both metanephric nephron tubule epithelial cells and kidney cortex tubule cells are subtypes of a shared parent cell type. Evidence regarding this shared entity states: 'Any epithelial cell that is part of some metanephric nephron tubule.' Which cell type is the direct parent of this shared entity? | kidney epithelial cell | Medium | convergence | {"qa_id":"medium_convergence_02504","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both metanephric nephron tubule epithelial cells and kidney cortex tubule cells are subtypes of a shared parent cell type. Evidence regarding this shared ent... | |
medium_convergence_02505 | HDAC1 and HDAC2 share interaction partners. One such partner is described in evidence stating: 'We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1.' Which cell type is this interaction partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_02505","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC2 share interaction partners. One such partner is described in evidence stating: 'We demonstrate that this repressor activity is due to interac... | |
medium_convergence_02506 | Both cerebellar granule cell differentiation and Lugaro cell differentiation are specific types of a broader biological process. Evidence regarding one of these specific processes states: 'The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar ... | hindbrain development | Medium | convergence | {"qa_id":"medium_convergence_02506","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both cerebellar granule cell differentiation and Lugaro cell differentiation are specific types of a broader biological process. Evidence regarding one of th... | |
medium_convergence_02507 | KIF11 and SIRT6 share a common interaction partner. Evidence indicates that this shared entity is part of a complex, described as a major ubiquitin ligase catalysing histone H2B monoubiquitination, which interacts with the motor protein Eg5 during mitosis and participates in spindle assembly. Which protein is encoded b... | E3 ubiquitin-protein ligase BRE1A | Medium | convergence | {"qa_id":"medium_convergence_02507","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KIF11 and SIRT6 share a common interaction partner. Evidence indicates that this shared entity is part of a complex, described as a major ubiquitin ligase ca... | |
medium_convergence_02508 | BET1L and COPB2 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which protein is encoded by the gene correspond... | Coatomer subunit epsilon | Medium | convergence | {"qa_id":"medium_convergence_02508","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BET1L and COPB2 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatome... | |
medium_convergence_02509 | TP53 and SQSTM1 share common interacting partners. One such partner is described in the following evidence: 'Here we have shown that the LIM domain protein [REDACTED] directly interacts with MDM2 to form a ternary complex with p53 in vitro and in human hepatoma and colon carcinoma cell lines and mouse embryonic fibrobl... | PDZ and LIM domain protein 7 | Medium | convergence | {"qa_id":"medium_convergence_02509","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and SQSTM1 share common interacting partners. One such partner is described in the following evidence: 'Here we have shown that the LIM domain protein [... | |
medium_convergence_02510 | ERBB2 and ERBB3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that it interacts with a kinase and increases its intrinsic kinase activity. Which protein is encoded by the gene corresponding to that shared partner? | Protein-tyrosine kinase 6 | Medium | convergence | {"qa_id":"medium_convergence_02510","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ERBB3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that it interacts with a ... | |
medium_convergence_02511 | CTNNB1 and YWHAG share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation experiments revealed that both endogenous and epitope-tagged deletion mutants of lp-dlg associated with beta-catenin.' Which protein is encoded by this shared interacting partner? | Disks large homolog 5 | Medium | convergence | {"qa_id":"medium_convergence_02511","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and YWHAG share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation experiments revealed that b... | |
medium_convergence_02512 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) reports a log2 fold change of approximately 1.008 and an adjusted p-value of 0.01415. Which protein does this gene product bind to? | PRTN3 | Medium | convergence | {"qa_id":"medium_convergence_02512","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GS... | |
medium_convergence_02514 | Interferon beta-1b and Warfarin share a common interacting drug. Evidence regarding this shared drug specifically describes pharmacodynamic and stereoselective pharmacokinetic interactions with Warfarin in humans, noting mechanism-based inhibition of CYP1A2 that affects (R)-warfarin clearance more than (S)-warfarin. Wh... | asthma | Medium | convergence | {"qa_id":"medium_convergence_02514","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1b and Warfarin share a common interacting drug. Evidence regarding this shared drug specifically describes pharmacodynamic and stereoselecti... | |
medium_convergence_02515 | Both Human immunodeficiency virus 1 and Zaire ebolavirus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of -1.856 and an adjusted p-value of 0.02523. Which biological process is this gene involved in? | N-acetylneuraminate catabolic process | Medium | convergence | {"qa_id":"medium_convergence_02515","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) ... | |
medium_convergence_02517 | MORF4L1 and CAVIN3 share interaction partners. One such shared partner was identified, along with MORF4L1, as being among the most up-regulated proteins following NEDD8 inhibition in multiple human cell lines. Which protein is encoded by this shared interaction partner? | MORF4 family-associated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02517","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MORF4L1 and CAVIN3 share interaction partners. One such shared partner was identified, along with MORF4L1, as being among the most up-regulated proteins foll... | |
medium_convergence_02518 | Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately 3.855 and an adjusted p-value of 0.04696. Which cellular component is this gene located in? | extracellular region | Medium | convergence | {"qa_id":"medium_convergence_02518","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (f... | |
medium_convergence_02519 | AREG and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that this entity associates directly with c-Cbl, a known down-regulator of RTK signaling.' Which disease is connected to that entity through genomic alterations? | Metaphyseal chondrodysplasia, McKusick type | Medium | convergence | {"qa_id":"medium_convergence_02519","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AREG and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that this entity associate... | |
medium_convergence_02520 | EP300 and FBL share multiple interacting partners. One such partner is described in evidence stating: 'We show that the interaction between E2 and hNAP-1 is direct and not merely mediated by the transcriptional coactivator p300, which is bound by both proteins.' Which protein, among the shared interactors of EP300 and ... | Nucleosome assembly protein 1-like 1 | Medium | convergence | {"qa_id":"medium_convergence_02520","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FBL share multiple interacting partners. One such partner is described in evidence stating: 'We show that the interaction between E2 and hNAP-1 is ... | |
medium_convergence_02521 | S100A8 and BTK share common binding partners. One such partner is identified in evidence stating that a protein, in complex with its binding partner MRP8 (which corresponds to S100A8), promotes the polymerization of microtubules. Which protein is encoded by this shared binding partner? | Protein S100-A9 | Medium | convergence | {"qa_id":"medium_convergence_02521","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"S100A8 and BTK share common binding partners. One such partner is identified in evidence stating that a protein, in complex with its binding partner MRP8 (wh... | |
medium_convergence_02523 | GABBR1 and GABBR2 both interact with a specific potassium channel protein. Evidence regarding this interaction states: 'Our data indicate that Kir 3 channels and Gbetagamma subunits can interact with the GABA-B(1) subunits independently of the GABA-B(2) subunit or Kir 3.4 which are ultimately responsible for their targ... | G protein-activated inward rectifier potassium channel 1 | Medium | convergence | {"qa_id":"medium_convergence_02523","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABBR1 and GABBR2 both interact with a specific potassium channel protein. Evidence regarding this interaction states: 'Our data indicate that Kir 3 channels... | |
medium_convergence_02524 | DAG1 and ITGB1 both interact with a common protein partner. Evidence regarding one such partner states: 'The RING-H2 domain interacts only with the beta-dystroglycan cytoplasmic domain.' Which protein is encoded by the gene corresponding to this partner? | 43 kDa receptor-associated protein of the synapse | Medium | convergence | {"qa_id":"medium_convergence_02524","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAG1 and ITGB1 both interact with a common protein partner. Evidence regarding one such partner states: 'The RING-H2 domain interacts only with the beta-dyst... | |
medium_convergence_02525 | FYN and NRP1 both bind to a shared protein. Evidence indicates that both the sema domain and the remainder of the ectodomain of this protein associate with NRP1 in a Sema3A-independent manner. Which gene product interacts with this shared protein? | CCDC7 | Medium | convergence | {"qa_id":"medium_convergence_02525","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and NRP1 both bind to a shared protein. Evidence indicates that both the sema domain and the remainder of the ectodomain of this protein associate with N... | |
medium_convergence_02526 | BCL11B and SMARCA4 both interact with a shared protein partner. Evidence regarding this partner states: 'A group of proteins associated with the gene product of the shared partner were affinity purified with antibodies against that gene product and were found to be identical to those co-purified with BRG1, strongly ind... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | Medium | convergence | {"qa_id":"medium_convergence_02526","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCL11B and SMARCA4 both interact with a shared protein partner. Evidence regarding this partner states: 'A group of proteins associated with the gene product... | |
medium_convergence_02527 | PCNA and RFC3 both interact with a specific protein. Experimental evidence indicates that Coimmunoprecipitation was performed to confirm the interaction between this protein and proliferating cell nuclear antigen (PCNA). Which protein is encoded by the gene corresponding to this interacting entity? | Ubiquitin carboxyl-terminal hydrolase 1 | Medium | convergence | {"qa_id":"medium_convergence_02527","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and RFC3 both interact with a specific protein. Experimental evidence indicates that Coimmunoprecipitation was performed to confirm the interaction betw... | |
medium_convergence_02528 | Both Human alphaherpesvirus 3 and Rhinovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 1.307 and an adjusted p-value of 9.543e-08. Which protein is encoded by this gene? | Cdc42 effector protein 3 | Medium | convergence | {"qa_id":"medium_convergence_02528","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Rhinovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in a melanoma cell li... |
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