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medium_convergence_02640 | MAPK8 and LRP8 share a common binding partner. Evidence regarding this shared partner describes it as a putative scaffold protein that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02640","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK8 and LRP8 share a common binding partner. Evidence regarding this shared partner describes it as a putative scaffold protein that interacts with multipl... | |
medium_convergence_02641 | Both IKBKG and IKBKE interact with a shared protein partner. Contextual evidence regarding this partner states: 'In mutational analyses based on the crystal structure of the complex between the [shared partner] NZF1 and NEMO CC2-LZ domains, which are involved in the [shared partner]-NEMO interaction, NEMO mutations tha... | E3 ubiquitin-protein ligase RNF31 | Medium | convergence | {"qa_id":"medium_convergence_02641","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKG and IKBKE interact with a shared protein partner. Contextual evidence regarding this partner states: 'In mutational analyses based on the crystal ... | |
medium_convergence_02642 | Infliximab and Oxaliplatin share a common interacting drug. Evidence regarding this shared entity states: 'All 3 toxins significantly increased the severity of paclitaxel-evoked and oxaliplatin-evoked mechano-allodynia and mechano-hyperalgesia.' Which disease is this shared drug indicated for? | arthritic joint disease | Medium | convergence | {"qa_id":"medium_convergence_02642","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Infliximab and Oxaliplatin share a common interacting drug. Evidence regarding this shared entity states: 'All 3 toxins significantly increased the severity ... | |
medium_convergence_02643 | COPS5 and AKT1 share common interacting partners. One such shared partner is described in evidence stating: 'Mechanistically, we found that CSN5 directly interacted and deubiquitinated the protein encoded by this shared partner for its stabilization in cardiomyocytes.' Which protein is encoded by the gene corresponding... | Serine/threonine-protein kinase STK11 | Medium | convergence | {"qa_id":"medium_convergence_02643","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and AKT1 share common interacting partners. One such shared partner is described in evidence stating: 'Mechanistically, we found that CSN5 directly int... | |
medium_convergence_02644 | Both West Nile virus and Measles morbillivirus are known to upregulate a specific shared gene. In a study of monocyte-derived dendritic cells (GSE136342), evidence for this gene shows a log2 fold change of approximately 1.415 and an adjusted p-value of 0.04609. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_02644","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Measles morbillivirus are known to upregulate a specific shared gene. In a study of monocyte-derived dendritic cells (GSE136342), ev... | |
medium_convergence_02645 | CREBBP and IFIH1 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that phosphorylation of this entity induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein. Which protein is encoded by that entity? | Interferon regulatory factor 3 | Medium | convergence | {"qa_id":"medium_convergence_02645","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and IFIH1 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that phosphorylation of this entit... | |
medium_convergence_02646 | YAP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with this partner has an additive effect on promoter activity, and the proteins were demonstrated to interact physically.' Which cellular component is this specific par... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02646","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with ... | |
medium_convergence_02647 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.92 and an adjusted p-value of 0.0494. Which protein is encoded by this gene? | Selenoprotein M | Medium | convergence | {"qa_id":"medium_convergence_02647","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) r... | |
medium_convergence_02648 | ACVR2B and ACVRL1 each interact with more than one shared ligand. Evidence concerning one shared entity reports: 'Although both forms of the ligand were capable of binding to the prodomain and ALK1, the M-form demonstrated less sustained induction of Smad1/5/8 phosphorylation.' Which protein is connected to that entity... | Growth/differentiation factor 2 | Medium | convergence | {"qa_id":"medium_convergence_02648","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACVR2B and ACVRL1 each interact with more than one shared ligand. Evidence concerning one shared entity reports: 'Although both forms of the ligand were capa... | |
medium_convergence_02649 | CENPQ and CENPT each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'The CENP-T·CENP-W complex is a recently identified inner centromere component that plays crucial roles in the formation of a functional kinetochore involved in cell division during mitosis.' Which di... | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02649","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPQ and CENPT each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'The CENP-T·CENP-W complex is a recen... | |
medium_convergence_02650 | GSK3B and NONO both interact with a shared protein entity. A specific report states: 'In this report, we demonstrated that PP1 forms a protein complex with both p54nrb and PSF.' Given that NONO is also known as p54nrb, which protein encoded by the gene corresponding to this shared entity is the subject of the question? | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_02650","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and NONO both interact with a shared protein entity. A specific report states: 'In this report, we demonstrated that PP1 forms a protein complex with b... | |
medium_convergence_02651 | BUB1B and CDC20 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'As CENP-E and hBUBR1 can coimmunoprecipitate with each other from HeLa cells, they may function as a motor-kinase complex at kinetochores.' Which disease is connected to that entity through genomic alterations? | Seckel syndrome | Medium | convergence | {"qa_id":"medium_convergence_02651","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB1B and CDC20 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'As CENP-E and hBUBR1 can coimmunoprecipitate wi... | |
medium_convergence_02652 | MYC and MAPK8 share multiple interacting partners. One of these shared partners is implicated by evidence stating: 'A search for SCCA-interacting molecules showed specific binding with phosphorylated JNK.' Identify the gene that interacts with this specific shared partner. | SERPINB4 | Medium | convergence | {"qa_id":"medium_convergence_02652","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and MAPK8 share multiple interacting partners. One of these shared partners is implicated by evidence stating: 'A search for SCCA-interacting molecules s... | |
medium_convergence_02654 | CCL5 and CCL18 both interact with a specific chemokine receptor. Experimental evidence indicates that a triple 40s mutant exhibits an 80-fold reduction in affinity for this receptor, while maintaining normal binding to CCR5. Which disease is associated with this receptor as a biomarker? | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02654","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL5 and CCL18 both interact with a specific chemokine receptor. Experimental evidence indicates that a triple 40s mutant exhibits an 80-fold reduction in af... | |
medium_convergence_02655 | ORC3 and ORC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which protein is connected to that shared partner through the 'encodes' relationshi... | Origin recognition complex subunit 6 | Medium | convergence | {"qa_id":"medium_convergence_02655","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ORC3 and ORC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports the following binary interactions:... | |
medium_convergence_02656 | Both Human alphaherpesvirus 3 and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene, derived from a melanoma cell line study (GSE136586), reports a log2 fold change of approximately 1.368 and an adjusted p-value of 2.707e-08. Which disease is associated with this gene? | mammary neoplasms, animal | Medium | convergence | {"qa_id":"medium_convergence_02656","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene, derived from a melanoma cell line s... | |
medium_convergence_02657 | COMMD1 and CUL3 each interact with more than one shared gene partner. Evidence concerning one shared entity reports: 'Here we identify the ubiquitin ligase CUL3 in complex with its vertebrate-specific substrate adaptor [ENTITY] (CUL3([ENTITY])) as an essential regulator of human and Xenopus tropicalis neural crest spec... | Cul3-RING ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_02657","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 each interact with more than one shared gene partner. Evidence concerning one shared entity reports: 'Here we identify the ubiquitin ligase C... | |
medium_convergence_02658 | SLC17A8 and FYN both interact with a specific NMDA receptor subunit. Experimental evidence indicates that after abdominal injection of LiCl (2 mg/kg) for 7 days, there was a significant decrease in I/R-induced tyrosine phosphorylation of this subunit, along with decreased interactions of this subunit with Src and FYN m... | Glutamate receptor ionotropic, NMDA 2A | Medium | convergence | {"qa_id":"medium_convergence_02658","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SLC17A8 and FYN both interact with a specific NMDA receptor subunit. Experimental evidence indicates that after abdominal injection of LiCl (2 mg/kg) for 7 d... | |
medium_convergence_02659 | STUB1 and HSPA4L both interact with a specific shared protein. Evidence indicates that this protein directly interacts with CHIP, and this interaction necessitates a conformational change in the protein induced by heat stress. Which disease is therapeutically linked to this protein? | amyotrophic lateral sclerosis type 1 | Medium | convergence | {"qa_id":"medium_convergence_02659","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HSPA4L both interact with a specific shared protein. Evidence indicates that this protein directly interacts with CHIP, and this interaction necess... | |
medium_convergence_02660 | Both ATR and ATRIP interact with a specific protein. Contextual evidence indicates that this protein interacts with the checkpoint proteins ATR and Rad9. Which disease is associated with this protein via a biomarker relationship? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02660","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ATR and ATRIP interact with a specific protein. Contextual evidence indicates that this protein interacts with the checkpoint proteins ATR and Rad9. Whi... | |
medium_convergence_02661 | FBXO6 and PDIA3 share a common interacting partner. Evidence regarding this partner states: 'We find PDI to be the main substrate of Ero1α, and mixed-disulphide complexes of Ero1 primarily form with PDI, to a lesser extent with the PDI-family members ERp57 and ERp72, but are not detectable with another homologue TMX3.'... | ERO1-like protein alpha | Medium | convergence | {"qa_id":"medium_convergence_02661","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXO6 and PDIA3 share a common interacting partner. Evidence regarding this partner states: 'We find PDI to be the main substrate of Ero1α, and mixed-disulph... | |
medium_convergence_02662 | TOPBP1 and PARP1 share common interaction partners. One such shared partner is functionally analogous to the budding yeast protein Fun30, as both are cell cycle-regulated through interaction with the DSB-localized scaffold proteins Dpb11 and TOPBP1, respectively. Which protein is encoded by this human shared partner? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_02662","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and PARP1 share common interaction partners. One such shared partner is functionally analogous to the budding yeast protein Fun30, as both are cell cy... | |
medium_convergence_02663 | EP300 and KDM1A each interact with more than one shared gene product. Evidence concerning one shared entity reports that p300 was found to coimmunoprecipitate with this entity in extracts from murine erythroleukemia (MEL) cells induced to differentiate with dimethylsulfoxide (DMSO), and p300 and this entity were observ... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02663","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and KDM1A each interact with more than one shared gene product. Evidence concerning one shared entity reports that p300 was found to coimmunoprecipitat... | |
medium_convergence_02664 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 2.95 and an adjusted p-value of 0.038. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02664","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_02665 | DNM1 and DNM2 both interact with a shared protein. Evidence indicates that this shared protein is concentrated at synapses in the brain and binds dynamin selectively through four N-terminal Src homology-3 (SH3) domains. Which cellular component is this shared protein located in? | cell-cell junction | Medium | convergence | {"qa_id":"medium_convergence_02665","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNM1 and DNM2 both interact with a shared protein. Evidence indicates that this shared protein is concentrated at synapses in the brain and binds dynamin sel... | |
medium_convergence_02666 | ACVR1C and ACVR1B each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that complexes can form between a truncated activin type IIA receptor and activin type IA and type IB receptors, as demonstrated by coimmunoprecipitation of these type I receptors with the tr... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_02666","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACVR1C and ACVR1B each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that complexes can form betw... | |
medium_convergence_02667 | COPS5 and BCL6 share multiple interacting partners. One such shared partner is described in evidence stating: 'We show that a ubiquitin carboxyl-terminal hydrolase interacts with at least three proteins, one of which is JAB1, a Jun activation domain binding protein that can bind to p27(Kip1) and is involved in the cyto... | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Medium | convergence | {"qa_id":"medium_convergence_02667","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and BCL6 share multiple interacting partners. One such shared partner is described in evidence stating: 'We show that a ubiquitin carboxyl-terminal hyd... | |
medium_convergence_02668 | Both INHBA and INHBE interact with multiple shared receptors. One of these shared receptors is the subject of a hypothesis stating: 'We hypothesized that, in addition to its canonical receptor, activin A might similarly bind and signal via BMPR2.' Which disease is associated with this specific receptor through genomic ... | malignant colon neoplasm | Medium | convergence | {"qa_id":"medium_convergence_02668","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both INHBA and INHBE interact with multiple shared receptors. One of these shared receptors is the subject of a hypothesis stating: 'We hypothesized that, in... | |
medium_convergence_02670 | XRCC6 and HSPA1A both interact with a specific shared protein. Experimental evidence regarding this shared protein indicates that binding of the protein encoded by ST13 to hsp70's ATPase domain was lost with deletions from the TPR and from an adjoining highly charged region, and correspondingly, these mutant forms were... | Hsc70-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_02670","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and HSPA1A both interact with a specific shared protein. Experimental evidence regarding this shared protein indicates that binding of the protein enco... | |
medium_convergence_02671 | GSK3B and HDAC1 share multiple interacting partners. One such partner is described by the following evidence: 'In the absence of Wnt signaling, the protein encoded by SNAI2 is phosphorylated by GSK3β and subsequently undergoes β-Trcp1-dependent ubiquitination and proteosomal degradation.' Which disease is associated wi... | piebaldism | Medium | convergence | {"qa_id":"medium_convergence_02671","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and HDAC1 share multiple interacting partners. One such partner is described by the following evidence: 'In the absence of Wnt signaling, the protein e... | |
medium_convergence_02672 | GABARAP and TBK1 both interact with a shared protein. Evidence regarding one such shared partner states: 'Strikingly, in addition to ULK1 and ULK2, ATG13 and a shared partner interacted with human ATG8 proteins, all with strong preference for the GABARAP subfamily.' Which protein is encoded by this shared partner? | RB1-inducible coiled-coil protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02672","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABARAP and TBK1 both interact with a shared protein. Evidence regarding one such shared partner states: 'Strikingly, in addition to ULK1 and ULK2, ATG13 and... | |
medium_convergence_02673 | VPS28 and UBC both interact with a shared protein. Evidence indicates that ESCRT-II binds to the ESCRT-I VPS28 C-terminal domain subunit through a helix located immediately C-terminal to the GLUE domain of this shared protein. Which cell type is enriched in this shared protein? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02673","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS28 and UBC both interact with a shared protein. Evidence indicates that ESCRT-II binds to the ESCRT-I VPS28 C-terminal domain subunit through a helix loca... | |
medium_convergence_02674 | ARPC3 and NCKIPSD each share a binding partner with another gene. Evidence concerning one such shared partner states: 'We have used deletion analysis to show that both the shared partner and Scar1 interact with the p21 subunit of the Arp2/3 complex through their carboxyl termini.' Which protein is encoded by that share... | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_02674","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC3 and NCKIPSD each share a binding partner with another gene. Evidence concerning one such shared partner states: 'We have used deletion analysis to show... | |
medium_convergence_02675 | HNRNPD and HSPA8 both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we demonstrate activation-induced subunit rearrangements within ASTRC and identify chaperone [HSPB1 protein] as a novel subunit that is itself an ARE-binding protein essential for rapid ARE-mRNA degradation.' Whic... | Heat shock protein beta-1 | Medium | convergence | {"qa_id":"medium_convergence_02675","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNRNPD and HSPA8 both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we demonstrate activation-induced subunit rearrang... | |
medium_convergence_02676 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Evidence for this shared target in peripheral blood mononuclear cells (from study GSE119117) reports a log2 fold change of approximately -2.93 and an adjusted p-value of 0.022. Which protein is encoded by this gene? | Cdc42 effector protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02676","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Evidence for this shared target in peripheral blood mononuclear cells (from study GSE119117... | |
medium_convergence_02677 | PCNA and AQR both interact with a specific protein. Experimental evidence indicates that this protein co-immunoprecipitates with human p50 and the calf thymus DNA polymerase delta heterodimer, but not with p125 alone, suggesting a direct interaction with p50 rather than p125. Which protein is encoded by the gene corres... | DNA polymerase delta subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_02677","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and AQR both interact with a specific protein. Experimental evidence indicates that this protein co-immunoprecipitates with human p50 and the calf thymu... | |
medium_convergence_02678 | ATM and BARD1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'We report here that [the gene encoding Mediator of DNA damage checkpoint protein 1] physically associates with ATM, p53, components of the MRE11-RAD50-NBS1 (MRN) complex, and gamma-H2AX.' Which protein... | Mediator of DNA damage checkpoint protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02678","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and BARD1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'We report here that [the gene encoding... | |
medium_convergence_02680 | DIS3 and EXOSC1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which disease is associated with this specific shared partner through genomic alterations? | pontocerebellar hypoplasia, type 1C | Medium | convergence | {"qa_id":"medium_convergence_02680","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we demonstrate the association of two differe... | |
medium_convergence_02681 | Vaccinia virus and Dengue virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.255 and an adjusted p-value of 0.04344. Which disease is associated with this gene? | Alkuraya-Kucinskas syndrome | Medium | convergence | {"qa_id":"medium_convergence_02681","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_02682 | CTNND1 and LCP2 both interact with a shared protein. Evidence regarding this shared protein states: 'Immunoprecipitation studies demonstrate association of SLP-76 with SLAP-130, Vav, Fyn, this shared protein, and the FcR gamma-chain in CRP-stimulated platelets.' Which protein is encoded by this shared entity? | Tyrosine-protein kinase Lyn | Medium | convergence | {"qa_id":"medium_convergence_02682","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNND1 and LCP2 both interact with a shared protein. Evidence regarding this shared protein states: 'Immunoprecipitation studies demonstrate association of S... | |
medium_convergence_02683 | CSK and CBL both physically interact with a specific protein. Experimental evidence indicates that C-Cbl physically interacts with this protein and undergoes tyrosine phosphorylation in the presence of the protein's ligand, FL. Which protein is encoded by the gene corresponding to this shared interaction partner? | Receptor-type tyrosine-protein kinase FLT3 | Medium | convergence | {"qa_id":"medium_convergence_02683","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSK and CBL both physically interact with a specific protein. Experimental evidence indicates that C-Cbl physically interacts with this protein and undergoes... | |
medium_convergence_02684 | Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a monocytic leukemia cell line (study GSE114966), reports a log2 fold change of approximately 1.007 and an adjusted p-value of 0.02828. Which disease is associate... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_02684","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from... | |
medium_convergence_02686 | HDAC1 and FOXK2 both interact with a specific protein that serves as a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex. Evidence indicates this subunit binds with high affinity to trimethylated species. Which protein is encoded by the gene corresponding to this interacting partner? | Inhibitor of growth protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02686","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and FOXK2 both interact with a specific protein that serves as a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex. Evidence indi... | |
medium_convergence_02687 | CENPA and CENPO each share a binding partner. Evidence concerning one such shared entity states: 'Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and a third protein), along with CENP-U(50), CEN... | H2BC8 | Medium | convergence | {"qa_id":"medium_convergence_02687","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPO each share a binding partner. Evidence concerning one such shared entity states: 'Here, we show that CENP-A nucleosomes directly recruit a pr... | |
medium_convergence_02688 | PPP1CA and BMPR1B each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that a growth arrest and DNA damage-inducible protein binds to protein phosphatase PP1 and can attenuate the translational elongation of key transcriptional factors through dephosphorylation ... | Protein phosphatase 1 regulatory subunit 15A | Medium | convergence | {"qa_id":"medium_convergence_02688","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP1CA and BMPR1B each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that a growth arrest and DNA... | |
medium_convergence_02690 | NEDD4L and NEDD4 both interact with a specific gene product. Evidence regarding this shared entity indicates it is subject to feedback inhibition by increased intracellular Na+, a regulatory mechanism wherein ubiquitin protein ligases (including Nedd4 and Nedd4-2) bind to conserved PY motifs in the C-termini of ENaC to... | Epithelial sodium channel subunit beta | Medium | convergence | {"qa_id":"medium_convergence_02690","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and NEDD4 both interact with a specific gene product. Evidence regarding this shared entity indicates it is subject to feedback inhibition by increase... | |
medium_convergence_02691 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of 4.620 and an adjusted p-value of 0.000496. Which disease is associated with this gene? | basal ganglia calcification, idiopathic, 10, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_02691","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_02692 | MCM3 and GINS1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays indicate that MCM3 does not interact directly with Stat1, suggesting that the presence of MCM3 in the group of Stat1TAD-interacting proteins is due to the association... | DNA replication licensing factor MCM5 | Medium | convergence | {"qa_id":"medium_convergence_02692","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM3 and GINS1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays ind... | |
medium_convergence_02693 | RNF11 and NEDD8 both interact with a shared protein. Experimental evidence for this shared interaction states: 'Using various mutants of RNF11 in GST pulldown and immunoprecipitation assays, we found that RNF11 interacts with this shared protein through the PY motif, leading to ubiquitination of both proteins.' Which p... | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_02693","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF11 and NEDD8 both interact with a shared protein. Experimental evidence for this shared interaction states: 'Using various mutants of RNF11 in GST pulldow... | |
medium_convergence_02694 | CHD3 and HDAC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'In the ovary, this protein interacted with NuRD proteins CHD4 and HDAC1 and the core cohesin complex protein RAD21.' Which molecular function is enabled by this protein? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02694","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and HDAC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'In the ovary, this protein inte... | |
medium_convergence_02695 | SEC61B and RNF43 both interact with a shared protein. Experimental evidence regarding this shared protein indicates that analysis of its interactome using BioID and immunoprecipitation demonstrated interactions with core receptor complex components of the noncanonical Wnt pathway, specifically ROR1, ROR2, and the share... | Vang-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02695","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC61B and RNF43 both interact with a shared protein. Experimental evidence regarding this shared protein indicates that analysis of its interactome using Bi... | |
medium_convergence_02696 | ANAPC2 and ANAPC7 both interact with a specific shared protein partner. Evidence regarding this partner indicates that the human homolog, CDC27, binds to APC16 and APC7, and contains a loop exceeding 200 residues that is heavily phosphorylated during mitosis. Which gene interacts with this shared partner? | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_02696","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC2 and ANAPC7 both interact with a specific shared protein partner. Evidence regarding this partner indicates that the human homolog, CDC27, binds to APC... | |
medium_convergence_02697 | GRB7 and GAB2 both interact with a common protein target. Experimental evidence indicates that while the adapter protein Grb2 binds to both phosphorylated Tyr-703 and phosphorylated Tyr-936 of this target, the adapter protein Grb7 binds selectively to phosphorylated Tyr-936. Which protein product is encoded by this com... | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_02697","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB7 and GAB2 both interact with a common protein target. Experimental evidence indicates that while the adapter protein Grb2 binds to both phosphorylated Ty... | |
medium_convergence_02698 | TRIM28 and YWHAQ both interact with a specific shared protein. Evidence indicates that KAP1 binds this shared protein, which functions as a transcription factor, in a retinoblastoma protein (pRb)-independent manner and inhibits its activity. Which gene encodes this shared protein? | Transcription factor E2F1 | Medium | convergence | {"qa_id":"medium_convergence_02698","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and YWHAQ both interact with a specific shared protein. Evidence indicates that KAP1 binds this shared protein, which functions as a transcription fac... | |
medium_convergence_02699 | ALYREF and CPSF4 both interact with a shared protein partner. Evidence regarding this partner states: 'Both proteins interact with the mRNA export factor Aly and both are able to rescue the loss of Sub2p (the yeast homolog of UAP56), indicating that both proteins have similar functions.' Which gene encodes this shared ... | ATP-dependent RNA helicase DDX39A | Medium | convergence | {"qa_id":"medium_convergence_02699","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and CPSF4 both interact with a shared protein partner. Evidence regarding this partner states: 'Both proteins interact with the mRNA export factor Aly... | |
medium_convergence_02700 | NUDT21 and DDB1 share a common interaction partner. Evidence regarding this shared partner states: 'Our results unexpectedly revealed a function independent of its transcriptional activity, as the shared partner was found to interact with DDB1 and block its binding to CHK1, which in turn attenuated ubiquitylation and s... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02700","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDT21 and DDB1 share a common interaction partner. Evidence regarding this shared partner states: 'Our results unexpectedly revealed a function independent ... | |
medium_convergence_02701 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately 5.04 and an adjusted p-value of 0.004083. Which cell type is this gene enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_02701","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of ap... | |
medium_convergence_02702 | MYO6 and PRKN (PARK2) share common interacting partners. One such shared partner is described in the following context: 'Here, we investigate the role of the endosomal adaptor [Entity] during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's disease-associated E3 ubi... | asthma | Medium | convergence | {"qa_id":"medium_convergence_02702","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYO6 and PRKN (PARK2) share common interacting partners. One such shared partner is described in the following context: 'Here, we investigate the role of the... | |
medium_convergence_02703 | ATM and BRCA2 each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity independently interacts with BRCA1 and BRCA2 through its NH2 and COOH termini, respectively. Which protein is encoded by the gene corresponding to that entity? | Partner and localizer of BRCA2 | Medium | convergence | {"qa_id":"medium_convergence_02703","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and BRCA2 each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity independently interacts with BR... | |
medium_convergence_02704 | CTNNA1 and PARD6A share multiple binding partners. One such shared partner is implicated in a complex where ECT2 interacts with Par6, Par3, and PKCzeta. Which protein is encoded by this shared partner? | Protein kinase C zeta type | Medium | convergence | {"qa_id":"medium_convergence_02704","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNA1 and PARD6A share multiple binding partners. One such shared partner is implicated in a complex where ECT2 interacts with Par6, Par3, and PKCzeta. Whic... | |
medium_convergence_02705 | NRAS and RAB6B share a common interacting partner. Experimental evidence indicates that a specific GTPase nucleotide-dissociation stimulator interacts with both dominant negative and nucleotide-free forms of H-Ras and this shared partner, but does not interact with their corresponding oncogenic forms. Which protein is ... | Rap1 GTPase-GDP dissociation stimulator 1 | Medium | convergence | {"qa_id":"medium_convergence_02705","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NRAS and RAB6B share a common interacting partner. Experimental evidence indicates that a specific GTPase nucleotide-dissociation stimulator interacts with b... | |
medium_convergence_02706 | H3F3A and AR share a common interacting partner. Evidence indicates that this shared partner specifically interacts with the DNA-binding domain of the androgen receptor via its HMG domain. Which protein is encoded by this shared partner? | Histone-lysine N-methyltransferase NSD2 | Medium | convergence | {"qa_id":"medium_convergence_02706","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3F3A and AR share a common interacting partner. Evidence indicates that this shared partner specifically interacts with the DNA-binding domain of the androg... | |
medium_convergence_02707 | WWP1 and WWP2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Additionally, our mass spectrometry results confirmed previously published information about [the shared gene] interaction with ubiquitin and the E3 ubiquitin-protein ligases, AIP4/Itch and AIP5/WWP1.' Which dise... | infectious mononucleosis | Medium | convergence | {"qa_id":"medium_convergence_02707","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP1 and WWP2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Additionally, our mass spectrometry results confi... | |
medium_convergence_02708 | The biological processes 'regulation of antimicrobial humoral response' and 'regulation of inflammatory response' share a common parent process in the ontology hierarchy. Evidence for one such shared parent process states: 'Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.'... | defense response | Medium | convergence | {"qa_id":"medium_convergence_02708","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of antimicrobial humoral response' and 'regulation of inflammatory response' share a common parent process in the ontolo... | |
medium_convergence_02709 | CHD3 and CTBP1 share multiple interacting partners. One such shared partner forms a repressor complex with CTBP1 in vivo. Which protein is encoded by this shared partner? | DNA-binding protein SATB1 | Medium | convergence | {"qa_id":"medium_convergence_02709","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and CTBP1 share multiple interacting partners. One such shared partner forms a repressor complex with CTBP1 in vivo. Which protein is encoded by this sh... | |
medium_convergence_02710 | ACTR1A and COPE both interact with a shared protein partner. Evidence regarding one such partner states: 'Affinity chromatography experiments demonstrate that the protein encoded by NCBIGene:51164 binds directly to the Arp1 subunit of dynactin.' Which disease is associated with this specific protein partner through gen... | cystic fibrosis | Medium | convergence | {"qa_id":"medium_convergence_02710","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and COPE both interact with a shared protein partner. Evidence regarding one such partner states: 'Affinity chromatography experiments demonstrate tha... | |
medium_convergence_02711 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.49 and an adjusted p-value of 0.037. Which cellular component is this gene produc... | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_02711","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T... | |
medium_convergence_02712 | HUWE1 and YWHAQ share multiple interaction partners. One such shared partner is described in evidence stating that 14-3-3tau binds to p21, MDM2, and the C8 subunit of the 20S proteasome during the G1 phase, thereby facilitating the proteasomal targeting of p21. Which protein is encoded by the gene corresponding to this... | Proteasome subunit alpha type-3 | Medium | convergence | {"qa_id":"medium_convergence_02712","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and YWHAQ share multiple interaction partners. One such shared partner is described in evidence stating that 14-3-3tau binds to p21, MDM2, and the C8 s... | |
medium_convergence_02713 | RBBP7 and SMARCA2 both interact with a shared protein complex component. Evidence indicates that a group of proteins associated with the gene product of the shared entity, affinity purified using antibodies against that gene product, were identical to those co-purified with BRG1, suggesting this group forms a tight ass... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | Medium | convergence | {"qa_id":"medium_convergence_02713","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBBP7 and SMARCA2 both interact with a shared protein complex component. Evidence indicates that a group of proteins associated with the gene product of the ... | |
medium_convergence_02714 | EPHB2 and GNAI1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that RasGAP binds through its SH2 domains to tyrosine-phosphorylated EPHB2 in vitro and complexes with activated EPHB2 in vivo. Which cellular component is this specific shared partner loc... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_02714","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPHB2 and GNAI1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that RasGAP binds through... | |
medium_convergence_02715 | BMP4 and ACVRL1 both interact with a common protein target. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and to a lesser extent BMP-4, bound to this shared receptor. Which protein is encoded by the gene corresponding to this shared binding partner? | Bone morphogenetic protein receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_02715","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP4 and ACVRL1 both interact with a common protein target. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7,... | |
medium_convergence_02716 | CD300A and FCGR2B are both associated with a shared biological process. Experimental evidence indicates that suppressing the expression of one of these entities in primary B cells using siRNA leads to increased BCR-mediated proliferation, thereby confirming its inhibitory role. Which biological process, connected to th... | B cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_02716","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD300A and FCGR2B are both associated with a shared biological process. Experimental evidence indicates that suppressing the expression of one of these entit... | |
medium_convergence_02717 | ATF7IP and H3C1 share a common binding partner. Evidence indicates that this shared entity, when acetylated, binds to histone H3 phosphorylated at threonine 11 (H3T11P). This interaction is essential for the DNA damage-induced reduction of H3T11P and the transcriptional repression of downstream target genes CDK1 and Cy... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_02717","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF7IP and H3C1 share a common binding partner. Evidence indicates that this shared entity, when acetylated, binds to histone H3 phosphorylated at threonine ... | |
medium_convergence_02718 | Lung vasculature and kidney vasculature share a common anatomical superclass. Evidence regarding this shared entity states: 'The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.' Which anatomical structure is this shared entity a part of? | trunk | Medium | convergence | {"qa_id":"medium_convergence_02718","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Lung vasculature and kidney vasculature share a common anatomical superclass. Evidence regarding this shared entity states: 'The lung vasculature is composed... | |
medium_convergence_02719 | Both 'regulation of monocyte chemotaxis' and 'regulation of dendritic cell chemotaxis' are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.' Which biological process is directly regulated by this sh... | leukocyte chemotaxis | Medium | convergence | {"qa_id":"medium_convergence_02719","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of monocyte chemotaxis' and 'regulation of dendritic cell chemotaxis' are subtypes of a shared biological process. Evidence regarding this s... | |
medium_convergence_02720 | Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene shows a log2 fold change of approximately -2.17 and an adjusted p-value of 0.0039. In which cellular component is the protein product of this gene located? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_02720","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene shows a log2 fold change of appro... | |
medium_convergence_02721 | DNAAF6 and DNAAF4 are both involved in more than one shared biological process. Evidence concerning one of these shared processes notes that ultrastructural and immunofluorescence analyses of DYX1C1-mutant motile cilia in mice and humans revealed disruptions of outer and inner dynein arms (ODAs and IDAs, respectively).... | inner dynein arm | Medium | convergence | {"qa_id":"medium_convergence_02721","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAAF6 and DNAAF4 are both involved in more than one shared biological process. Evidence concerning one of these shared processes notes that ultrastructural ... | |
medium_convergence_02722 | KPNB1 and MYC both interact with a shared protein. Evidence regarding this shared protein states: 'Instead, it formed stable complexes with several importins (-β, -7, -β/7, -13, and transportin 1) and was also imported into the nucleus in digitonin-permeabilized cells by these factors.' Which protein is encoded by the ... | Nitric oxide synthase-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_02722","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNB1 and MYC both interact with a shared protein. Evidence regarding this shared protein states: 'Instead, it formed stable complexes with several importins... | |
medium_convergence_02723 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene includes a log2 fold change of 2.175 and an adjusted p-value of 0.0344. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02723","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene includes a log2 fold change of 2.175 and an adjusted p-value of 0.0344... | |
medium_convergence_02724 | SUGT1 and MAPK14 share multiple interacting partners. One such partner is described in evidence stating: 'We show that p38alpha MAP kinase, in a phosphorylation-dependent manner, can directly interact with the alpha and beta subunits of CK2 to activate the holoenzyme through what appears to be an allosteric mechanism.'... | lymphoma | Medium | convergence | {"qa_id":"medium_convergence_02724","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SUGT1 and MAPK14 share multiple interacting partners. One such partner is described in evidence stating: 'We show that p38alpha MAP kinase, in a phosphorylat... | |
medium_convergence_02726 | HSPA1A and AR share multiple interacting partners. One such shared partner is described by evidence stating that its largest isoform, Bag-1L, enhances the transactivation function of the androgen receptor. Which protein is encoded by this shared partner? | BAG family molecular chaperone regulator 1 | Medium | convergence | {"qa_id":"medium_convergence_02726","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and AR share multiple interacting partners. One such shared partner is described by evidence stating that its largest isoform, Bag-1L, enhances the tr... | |
medium_convergence_02727 | Cyclosporine and Vemurafenib share a common interacting drug. Evidence regarding this shared drug indicates that a pharmacokinetic model performed well in recovering the observed effects of the CYP3A4 inhibitors ketoconazole and this shared drug, as well as the CYP3A4 inducer rifampicin, and in predicting interactions ... | pulmonary arterial hypertension | Medium | convergence | {"qa_id":"medium_convergence_02727","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Vemurafenib share a common interacting drug. Evidence regarding this shared drug indicates that a pharmacokinetic model performed well in re... | |
medium_convergence_02728 | CNOT1 and EIF3A each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In this report, we show that the protein self-associates and also interacts directly with the p170 subunit of eIF3.' Which disease is associated with that specific protein as a biomarker? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_02728","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT1 and EIF3A each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In this report, we show th... | |
medium_convergence_02729 | EPN1 and CBL both interact with a specific shared protein. Evidence regarding this protein's family indicates that Sprouty2 tyrosine phosphorylation is necessary for its binding to the Src homology 2-like domain of c-Cbl after fibroblast growth factor (FGF) stimulation. Which biological process is the shared protein in... | negative regulation of fibroblast growth factor receptor signaling pathway | Medium | convergence | {"qa_id":"medium_convergence_02729","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPN1 and CBL both interact with a specific shared protein. Evidence regarding this protein's family indicates that Sprouty2 tyrosine phosphorylation is neces... | |
medium_convergence_02730 | PEX5 and UBC each interact with more than one shared protein. Evidence concerning one shared entity reports that OspG binds host E2 ubiquitin-conjugating enzymes activated with ubiquitin (E2~Ub), a key enzyme complex in ubiquitin transfer pathways. Which protein is connected to that entity through the 'encodes' relatio... | Ubiquitin-conjugating enzyme E2 D3 | Medium | convergence | {"qa_id":"medium_convergence_02730","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PEX5 and UBC each interact with more than one shared protein. Evidence concerning one shared entity reports that OspG binds host E2 ubiquitin-conjugating enz... | |
medium_convergence_02732 | CREBBP and CTNNB1 share multiple binding partners. One of these shared partners was identified via cloning based on its ability to bind CBP. Which disease is associated with this specific shared partner through genomic alterations? | Floating-Harbor syndrome | Medium | convergence | {"qa_id":"medium_convergence_02732","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and CTNNB1 share multiple binding partners. One of these shared partners was identified via cloning based on its ability to bind CBP. Which disease is... | |
medium_convergence_02733 | NPM1 and PTEN share multiple interacting partners. Experimental evidence indicates that for one specific shared partner, altered binding was confirmed via affinity pull-down and Western blotting for Prdx1, a thioredoxin family member, and Anxa2, whereas DDB1 was validated as a novel interactor with unaltered binding. W... | Thioredoxin | Medium | convergence | {"qa_id":"medium_convergence_02733","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NPM1 and PTEN share multiple interacting partners. Experimental evidence indicates that for one specific shared partner, altered binding was confirmed via af... | |
medium_convergence_02734 | EFNB1 and EPHB2 share multiple binding partners. One such partner is identified by evidence stating: 'In vitro studies demonstrated that the fifth PDZ domain of FAP-1 and full-length syntenin bound ephrin B1 via the carboxyl-terminal motif.' Which cell type is this specific partner enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02734","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EFNB1 and EPHB2 share multiple binding partners. One such partner is identified by evidence stating: 'In vitro studies demonstrated that the fifth PDZ domain... | |
medium_convergence_02735 | AKAP10 and PRKACA share a common binding partner. Evidence for this interaction states: 'Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha.' Which disease is associated with this shared partner via a biomarker relationship? | neonatal severe primary hyperparathyroidism | Medium | convergence | {"qa_id":"medium_convergence_02735","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP10 and PRKACA share a common binding partner. Evidence for this interaction states: 'Based on coprecipitation assays, the R binding domain interacts with... | |
medium_convergence_02736 | Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this shared target in non-small cell lung adenocarcinoma cells (study GSE147507) reports a log2 fold change of 2.408 and an adjusted p-value of 0.04933. Which protein is encoded by this gene? | Guanylate-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02736","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this shared target in non-small ... | |
medium_convergence_02737 | PTK2B and CBLC both interact with a shared protein. Evidence regarding this shared protein states: 'After its stimulation, there was an increase in the association of the src cytoplasmic tyrosine kinase and the adapter protein Grb2.' Which protein is encoded by this shared entity? | Tyrosine-protein kinase Fyn | Medium | convergence | {"qa_id":"medium_convergence_02737","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PTK2B and CBLC both interact with a shared protein. Evidence regarding this shared protein states: 'After its stimulation, there was an increase in the assoc... | |
medium_convergence_02738 | NMU and GNAQ both interact with a specific receptor protein. Evidence indicates that radiolabeled neuromedin U binds with high affinity to membrane fractions prepared from cells expressing this receptor. Which protein is encoded by the gene corresponding to this receptor? | Neuromedin-U receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_02738","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NMU and GNAQ both interact with a specific receptor protein. Evidence indicates that radiolabeled neuromedin U binds with high affinity to membrane fractions... | |
medium_convergence_02739 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.295 and an adjusted p-value of 0.04313. Which disease is associated with this gene as a biomarker? | thymic carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02739","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change... | |
medium_convergence_02740 | FRS2 and CBL share a common binding partner. Evidence indicates that this shared entity associates directly with c-Cbl, a known down-regulator of RTK signaling. Which protein is encoded by this shared entity? | Protein sprouty homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_02740","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FRS2 and CBL share a common binding partner. Evidence indicates that this shared entity associates directly with c-Cbl, a known down-regulator of RTK signali... | |
medium_convergence_02741 | ESR1 and BRD4 share a common interaction partner. Experimental evidence indicates that this partner interacts with ER alpha in a ligand-dependent manner and with ER beta in a ligand-independent manner, as demonstrated by immunoprecipitation and glutathione-S-transferase pull-down assays. Which cell type is enriched for... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_02741","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and BRD4 share a common interaction partner. Experimental evidence indicates that this partner interacts with ER alpha in a ligand-dependent manner and ... | |
medium_convergence_02742 | FUS and HNRNPA1 share multiple interacting partners. One such partner is described by evidence stating: 'In in vitro pull-down assays, HAP interacts with hnRNP A1, through its S/K-R/E-rich region, and with several other hnRNPs.' Which cellular component is this specific interacting partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02742","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FUS and HNRNPA1 share multiple interacting partners. One such partner is described by evidence stating: 'In in vitro pull-down assays, HAP interacts with hnR... | |
medium_convergence_02743 | AGO3 and MOV10 both interact with a shared protein partner. Evidence indicates that this partner, along with its homologs, associates with all four human Argonaute proteins (AGO1-AGO4) that are already loaded with microRNAs. Which cell type is this specific protein partner enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02743","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGO3 and MOV10 both interact with a shared protein partner. Evidence indicates that this partner, along with its homologs, associates with all four human Arg... | |
medium_convergence_02744 | The facial nucleus and the locus ceruleus share a common anatomical classification. Evidence regarding one of these structures describes it as 'The group of motor neurons residing in the pons that innervate the muscles of facial expression.' Based on this description, which shared anatomical category is connected to th... | brainstem | Medium | convergence | {"qa_id":"medium_convergence_02744","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The facial nucleus and the locus ceruleus share a common anatomical classification. Evidence regarding one of these structures describes it as 'The group of ... | |
medium_convergence_02745 | MDM2 and ACE2 share common interacting partners. One such shared partner is distinguished by the fact that its N-terminal region (or that of its paralog RPS27L) binds to the central acidic domain of MDM2. Which disease is associated with this specific shared partner via a biomarker relationship? | Gaucher disease | Medium | convergence | {"qa_id":"medium_convergence_02745","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and ACE2 share common interacting partners. One such shared partner is distinguished by the fact that its N-terminal region (or that of its paralog RPS2... | |
medium_convergence_02746 | PIAS3 and EZH2 both interact with a specific shared protein. Experimental evidence indicates that PIAS3 interacts with Smad proteins, with the strongest interaction observed with this specific shared entity. Which protein is encoded by this shared entity? | SMAD family member 3 | Medium | convergence | {"qa_id":"medium_convergence_02746","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIAS3 and EZH2 both interact with a specific shared protein. Experimental evidence indicates that PIAS3 interacts with Smad proteins, with the strongest inte... |
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