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medium_convergence_02529 | GRB2 and SYK both interact with a specific shared protein. Evidence indicates that this protein, like c-cbl, is phosphorylated and recruited to the EGFR upon EGF stimulation, and it binds to the Grb2 adaptor protein. Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase CBL-B | Medium | convergence | {"qa_id":"medium_convergence_02529","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and SYK both interact with a specific shared protein. Evidence indicates that this protein, like c-cbl, is phosphorylated and recruited to the EGFR upon... | |
medium_convergence_02530 | Vaccinia virus and Influenza A virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.985 and an adjusted p-value of 0.01499. Which protein is encoded by this gene? | Suppressor of tumorigenicity 14 protein | Medium | convergence | {"qa_id":"medium_convergence_02530","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Influenza A virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE1123... | |
medium_convergence_02531 | LILRB4 and MIR98 are both associated with multiple shared biological processes. One shared process is supported by evidence stating: 'The current study revealed that miR-98 could ameliorate STAT3-mediated cell proliferation and inflammatory cytokine production via its target gene IL-6 in patients with SLE.' Which biolo... | cytokine production involved in inflammatory response | Medium | convergence | {"qa_id":"medium_convergence_02531","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LILRB4 and MIR98 are both associated with multiple shared biological processes. One shared process is supported by evidence stating: 'The current study revea... | |
medium_convergence_02533 | H1-0 and HDAC2 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we show that this entity (refs 4, 5, 6, 7, 8) interacts, both in vitro and in vivo, with histone deacetylase (HDAC) proteins.' Which protein is encoded by that entity? | Polycomb protein EED | Medium | convergence | {"qa_id":"medium_convergence_02533","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H1-0 and HDAC2 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we show that this entity (refs 4, 5... | |
medium_convergence_02534 | SMG1 and RUVBL1 share a common interacting partner. Evidence indicates that this shared partner interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which disease is associated with this entity? | neurodevelopmental disorder with microcephaly and movement abnormalities | Medium | convergence | {"qa_id":"medium_convergence_02534","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and RUVBL1 share a common interacting partner. Evidence indicates that this shared partner interacts with and stabilizes all six members of the PIKK fam... | |
medium_convergence_02535 | Human respirovirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately -1.167 and an adjusted p-value of 0.04685. Which protein is encoded by this gene? | SAM and SH3 domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02535","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (st... | |
medium_convergence_02536 | BMP2 and BMPR1A both interact with a shared protein. Evidence regarding this shared protein states: 'These residues are phosphorylated directly by a BMP type I receptor in vitro.' Which protein is encoded by the gene corresponding to this shared entity? | SMAD family member 1 | Medium | convergence | {"qa_id":"medium_convergence_02536","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMPR1A both interact with a shared protein. Evidence regarding this shared protein states: 'These residues are phosphorylated directly by a BMP type... | |
medium_convergence_02537 | YAP1 and DDB1 share multiple interacting partners. One such shared partner localizes to photolesions and associates with DDB1 to promote the assembly and activity of the DDB2-DDB1-Cul4A-Roc1 (CRL4(DDB2)) ubiquitin ligase complex. Which protein is encoded by this shared partner? | UV radiation resistance-associated gene protein | Medium | convergence | {"qa_id":"medium_convergence_02537","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and DDB1 share multiple interacting partners. One such shared partner localizes to photolesions and associates with DDB1 to promote the assembly and act... | |
medium_convergence_02539 | RBCK1 and CCDC50 both interact with a shared protein. Evidence regarding one such shared partner states: 'Using a yeast two-hybrid system to search for proteins interacting with TNFAIP3, we identified one novel binding protein, Ymer.' Which cell type is enriched for this specific shared protein? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_02539","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBCK1 and CCDC50 both interact with a shared protein. Evidence regarding one such shared partner states: 'Using a yeast two-hybrid system to search for prote... | |
medium_convergence_02540 | DIS3 and EXOSC10 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein, encoded by the gene corresponding to this shared partner, is the final answer? | Exosome complex component RRP41 | Medium | convergence | {"qa_id":"medium_convergence_02540","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC10 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we demonstrate the association of two differ... | |
medium_convergence_02541 | ARPC2 and AP2B1 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which disease is associated with this prot... | esophageal squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02541","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC2 and AP2B1 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 comple... | |
medium_convergence_02542 | TOPBP1 and AR share multiple interacting partners. One such shared partner is characterized by an interaction with a transcription factor that was confirmed in vitro and in vivo, mediated specifically by the ePHD domain of the transcription factor and the BRCT6 domain of the shared partner. Which protein is encoded by ... | Transcription factor 20 | Medium | convergence | {"qa_id":"medium_convergence_02542","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and AR share multiple interacting partners. One such shared partner is characterized by an interaction with a transcription factor that was confirmed ... | |
medium_convergence_02543 | The olfactory bulb layer and the layer of the lateral geniculate body are both classified as types of a specific anatomical structure. Evidence regarding this shared classification cites a missing definition for term UBERON:0004001. Which broader anatomical system is this shared structure a part of? | nervous system | Medium | convergence | {"qa_id":"medium_convergence_02543","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The olfactory bulb layer and the layer of the lateral geniculate body are both classified as types of a specific anatomical structure. Evidence regarding thi... | |
medium_convergence_02544 | DAB1 and MAP2K7 both interact with a common protein. Evidence regarding this shared partner states: 'In vitro protein kinase assays demonstrate that MKK7 phosphorylates and activates a specific MAP kinase, but not the p38 or extracellular signal-regulated kinase groups of MAP kinase.' Which protein is encoded by the ge... | Mitogen-activated protein kinase 8 | Medium | convergence | {"qa_id":"medium_convergence_02544","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB1 and MAP2K7 both interact with a common protein. Evidence regarding this shared partner states: 'In vitro protein kinase assays demonstrate that MKK7 pho... | |
medium_convergence_02545 | CSNK1G3 and CTNNB1 both interact with a specific protein. Evidence regarding this protein states: 'In contrast, co-precipitation between GSK3beta and beta-catenin was only observed in LNCapFGC cells, and increased upon continued exposure to the motogen HGF/SF.' Which protein is encoded by the gene corresponding to this... | Glycogen synthase kinase-3 beta | Medium | convergence | {"qa_id":"medium_convergence_02545","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1G3 and CTNNB1 both interact with a specific protein. Evidence regarding this protein states: 'In contrast, co-precipitation between GSK3beta and beta-ca... | |
medium_convergence_02546 | Morphine and Hydrocodone share a common interacting drug. Evidence indicates that this shared drug delayed the development of morphine analgesic tolerance. Which disease is this shared drug indicated for? | congestive heart failure | Medium | convergence | {"qa_id":"medium_convergence_02546","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Hydrocodone share a common interacting drug. Evidence indicates that this shared drug delayed the development of morphine analgesic tolerance. W... | |
medium_convergence_02547 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.130 and an adjusted p-value of 0.000465. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_02547","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 f... | |
medium_convergence_02548 | HRAS and CCL4 share multiple interaction partners. One such partner is characterized by evidence stating that Ras transforming activity correlates best with the ability of the encoded protein to interact with a Raf kinase. Which cell type is this specific partner enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02548","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and CCL4 share multiple interaction partners. One such partner is characterized by evidence stating that Ras transforming activity correlates best with ... | |
medium_convergence_02549 | TRIM28 and TOPBP1 both interact with a specific shared protein. Experimental evidence indicates that the interaction between KAP-1 and this shared protein was verified by co-immunoprecipitation (Co-IP). Which protein product is encoded by this shared protein? | Probable ATP-dependent RNA helicase DDX5 | Medium | convergence | {"qa_id":"medium_convergence_02549","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and TOPBP1 both interact with a specific shared protein. Experimental evidence indicates that the interaction between KAP-1 and this shared protein wa... | |
medium_convergence_02551 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 2.17 and an adjusted p-value of approximately 5.52e-07. Which protein does this gene product interact with? | RHOB | Medium | convergence | {"qa_id":"medium_convergence_02551","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_02552 | KCNH2 and KCNQ1 are both involved in more than one shared biological process. One of these shared processes is linked to the gene KVLQT1 (also known as KCNQ1), with evidence stating: 'These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricu... | regulation of cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_02552","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNH2 and KCNQ1 are both involved in more than one shared biological process. One of these shared processes is linked to the gene KVLQT1 (also known as KCNQ1... | |
medium_convergence_02553 | EZH2 and HIST1H4A share interaction partners. One such shared partner is distinguished by evidence reporting different fractionation patterns compared to RbAp48, with all three identified as interaction partners of H4 histone. Which protein is encoded by this specific shared partner? | Histone acetyltransferase type B catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_02553","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and HIST1H4A share interaction partners. One such shared partner is distinguished by evidence reporting different fractionation patterns compared to RbA... | |
medium_convergence_02554 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.073 and an adjusted p-value of 0.003982. Which cellular component is this gene located in? | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_02554","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) ... | |
medium_convergence_02555 | H3F3A and ASF1B both interact with a specific protein complex subunit. Evidence indicates that this entity functions as a histone chaperone that deposits the replication-coupled H3.1 histone variant during S-phase and associates with H3.3 throughout the cell cycle in vivo. Which protein is encoded by the gene correspon... | Chromatin assembly factor 1 subunit B | Medium | convergence | {"qa_id":"medium_convergence_02555","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3F3A and ASF1B both interact with a specific protein complex subunit. Evidence indicates that this entity functions as a histone chaperone that deposits the... | |
medium_convergence_02556 | DAZ1 and DAZL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that this entity, a human homolog of Pumilio, a protein required to maintain germ line stem cells in Drosophila and Caenorhabditis elegans, forms a stable complex with DAZ through the same functi... | Pumilio homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_02556","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAZ1 and DAZL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we show that this entity, a human homolo... | |
medium_convergence_02557 | MAP3K4 and MAP3K5 both interact with a shared downstream kinase. Evidence regarding this shared entity states: 'The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAPKKKs), including MTK1 (MEKK4), ASK1, TAK1, TAO2, MEKK1, and Raf-1.' Which protein is encoded by this shared kinase? | Dual specificity mitogen-activated protein kinase kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_02557","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP3K4 and MAP3K5 both interact with a shared downstream kinase. Evidence regarding this shared entity states: 'The DVD sites bind to their specific upstream... | |
medium_convergence_02558 | BRD4 and ANLN both interact with a shared protein entity. Experimental evidence indicates that this entity interacts with replication factor C (RFC), a conserved five-subunit complex essential for DNA replication, as demonstrated by coimmunoprecipitation experiments involving endogenous and transfected forms of the ent... | Replication factor C subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_02558","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and ANLN both interact with a shared protein entity. Experimental evidence indicates that this entity interacts with replication factor C (RFC), a conse... | |
medium_convergence_02559 | POMP and PSMA3 share common interaction partners. One such shared partner is described in evidence stating: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which disease is associated with this spe... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_02559","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POMP and PSMA3 share common interaction partners. One such shared partner is described in evidence stating: 'In the present study, we demonstrate that the 20... | |
medium_convergence_02560 | ADRM1 and PSMA4 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared p... | Proteasome subunit alpha type-5 | Medium | convergence | {"qa_id":"medium_convergence_02560","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMA4 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20... | |
medium_convergence_02561 | RSPO2 and RSPO3 both interact with a specific shared protein partner. Experimental evidence indicates that for this partner, the monovalent and bivalent forms of the RSPO furin domain exhibit nearly identical binding affinities. In contrast, for other partners like LGR4 or RNF43, the monovalent form shows much lower af... | Leucine-rich repeat-containing G-protein coupled receptor 5 | Medium | convergence | {"qa_id":"medium_convergence_02561","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RSPO2 and RSPO3 both interact with a specific shared protein partner. Experimental evidence indicates that for this partner, the monovalent and bivalent form... | |
medium_convergence_02562 | Both PPP1CA and PPP1CC interact with a specific shared protein partner. Experimental evidence indicates that the yeast two-hybrid system was used to identify cDNAs encoding proteins that interact with the gamma 1 isoform of human protein phosphatase 1. Which biological process is this shared partner involved in? | generation of precursor metabolites and energy | Medium | convergence | {"qa_id":"medium_convergence_02562","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both PPP1CA and PPP1CC interact with a specific shared protein partner. Experimental evidence indicates that the yeast two-hybrid system was used to identify... | |
medium_convergence_02563 | BRD4 and MDM2 share multiple protein interaction partners. One such shared partner is characterized by evidence stating: 'Further studies revealed that this protein interacted with MDM2 and promoted low levels of MDM2-mediated p53 ubiquitination in vitro and in vivo.' Which protein is encoded by this shared interaction... | BAR/IMD domain-containing adapter protein 2-like 1 | Medium | convergence | {"qa_id":"medium_convergence_02563","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and MDM2 share multiple protein interaction partners. One such shared partner is characterized by evidence stating: 'Further studies revealed that this ... | |
medium_convergence_02564 | STUB1 and AMBRA1 both interact with a common protein partner. Evidence regarding this partner states: 'The interaction of CHIP with this partner is mediated by Hsp70 which binds to the tetratricopeptide repeat domain of CHIP and the BAG domains of this partner.' Which protein product is encoded by this shared partner? | BAG family molecular chaperone regulator 5 | Medium | convergence | {"qa_id":"medium_convergence_02564","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and AMBRA1 both interact with a common protein partner. Evidence regarding this partner states: 'The interaction of CHIP with this partner is mediated ... | |
medium_convergence_02565 | HSCB and DLAT each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that it demonstrated a very tight binding, which persisted during isolation of its complexes with L2 using size-exclusion chromatography. Which protein is connected to that entity through the 'encodes... | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_02565","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSCB and DLAT each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that it demonstrated a very tight bin... | |
medium_convergence_02566 | NEDD4L and TSG101 both interact with a common protein partner. Experimental evidence indicates that this partner, along with TSG101, co-immunoprecipitated with VPS37B-FLAG, and the three proteins comigrated together in soluble complexes of the correct size for human ESCRT-I (approximately 350 kDa). Which gene is connec... | AKTIP | Medium | convergence | {"qa_id":"medium_convergence_02566","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and TSG101 both interact with a common protein partner. Experimental evidence indicates that this partner, along with TSG101, co-immunoprecipitated wi... | |
medium_convergence_02567 | CEBPA and CEBPB both interact with a shared protein. Experimental evidence indicates that coimmunoprecipitation experiments provided evidence for the formation of endogenous complexes between this shared protein and C/EBP-beta in arsenite-treated cells. Which disease is associated with this shared protein as a biomarke... | idiopathic pulmonary fibrosis | Medium | convergence | {"qa_id":"medium_convergence_02567","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and CEBPB both interact with a shared protein. Experimental evidence indicates that coimmunoprecipitation experiments provided evidence for the formati... | |
medium_convergence_02568 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line shows a log2 fold change of approximately 1.26 and an adjusted p-value of 0.027. Which protein is encoded by this gene? | Frizzled-4 | Medium | convergence | {"qa_id":"medium_convergence_02568","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line shows a l... | |
medium_convergence_02569 | CREBBP and HSPA8 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Additionally, the protein product of this gene was shown to interact in vitro and in vivo with p300 segments harboring C/H1 domain.' Which protein is connected to that entity through the 'encodes' rela... | Lysine-specific demethylase RAD23A | Medium | convergence | {"qa_id":"medium_convergence_02569","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HSPA8 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Additionally, the protein product of t... | |
medium_convergence_02570 | HSPA1A and PSEN1 both interact with a specific shared protein. Experimental evidence regarding this shared protein indicates that binding of a chaperone co-factor to hsp70's ATPase domain was lost with deletions from the TPR and from an adjoining highly charged region, and correspondingly, these mutant forms were not r... | Hsc70-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_02570","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and PSEN1 both interact with a specific shared protein. Experimental evidence regarding this shared protein indicates that binding of a chaperone co-f... | |
medium_convergence_02571 | H3-3A and MYB each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here we report that [the protein encoded by the shared gene] directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation.' Which protein is connected to that entity through ... | Transcription intermediary factor 1-beta | Medium | convergence | {"qa_id":"medium_convergence_02571","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3-3A and MYB each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here we report that [the protein encod... | |
medium_convergence_02573 | AP3M1 and RUFY1 share common interacting partners. One such shared partner is identified in an interactor screen for proteins functioning with rabip4', which yielded the adaptor protein complex AP-3; specifically, the hinge region of the beta-3 subunit was found to bind directly to the FYVE domain of rabip4'. Which gen... | AP-3 complex subunit beta-2 | Medium | convergence | {"qa_id":"medium_convergence_02573","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP3M1 and RUFY1 share common interacting partners. One such shared partner is identified in an interactor screen for proteins functioning with rabip4', which... | |
medium_convergence_02574 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 2.95 and an adjusted p-value of approximately 0.039. Which protein is encoded by this gene? | Transcription factor SOX-9 | Medium | convergence | {"qa_id":"medium_convergence_02574","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 f... | |
medium_convergence_02575 | PSMC1 and PSMC4 both interact with a common protein partner. Evidence indicates that a yeast two-hybrid screen using the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome identified gankyrin, a liver oncoprotein, as an interacting protein. Which disease is associated with this specific interacting protein via a bioma... | malignant pancreatic neoplasm | Medium | convergence | {"qa_id":"medium_convergence_02575","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMC1 and PSMC4 both interact with a common protein partner. Evidence indicates that a yeast two-hybrid screen using the human S6 (TBP7, RPT3) ATPase of the ... | |
medium_convergence_02576 | FAAP20 and FANCE each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The human protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E.' Which protein is encoded by the gene correspond... | Fanconi anemia group F protein | Medium | convergence | {"qa_id":"medium_convergence_02576","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAAP20 and FANCE each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The human protein reporte... | |
medium_convergence_02577 | RHOA and MYC both interact with a shared protein. Experimental evidence confirms direct binding and in vivo association between c-Myc and this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Rho guanine nucleotide exchange factor TIAM1 | Medium | convergence | {"qa_id":"medium_convergence_02577","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and MYC both interact with a shared protein. Experimental evidence confirms direct binding and in vivo association between c-Myc and this shared protein... | |
medium_convergence_02578 | CTNNB1 and MLLT4 both interact with a shared protein. Experimental evidence indicates that AF-6 was co-immunoprecipitated with the protein encoded by TJP1 from Rat1 cells. Which protein is encoded by the gene corresponding to this shared interaction partner? | Tight junction protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02578","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and MLLT4 both interact with a shared protein. Experimental evidence indicates that AF-6 was co-immunoprecipitated with the protein encoded by TJP1 fr... | |
medium_convergence_02579 | DAG1 and MUSK share a common binding partner. Evidence regarding this shared entity states: 'The RING-H2 domain interacts only with the beta-dystroglycan cytoplasmic domain.' Which protein is connected to this shared entity through the 'encodes' relationship? | 43 kDa receptor-associated protein of the synapse | Medium | convergence | {"qa_id":"medium_convergence_02579","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAG1 and MUSK share a common binding partner. Evidence regarding this shared entity states: 'The RING-H2 domain interacts only with the beta-dystroglycan cyt... | |
medium_convergence_02580 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (study GSE119117) shows a log2 fold change of approximately -1.07 and an adjusted p-value of approximately 0.018. Which cellular component is this gene located in? | focal adhesion | Medium | convergence | {"qa_id":"medium_convergence_02580","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (study GSE119117) sho... | |
medium_convergence_02581 | TOPBP1 and FOXM1 share multiple interacting partners. One such shared partner is described in literature where initial co-immunoprecipitation studies verified previous proteomic analysis findings that this entity is a novel FOXM1-interacting protein. Which protein is encoded by this shared interacting partner? | Ubiquitin thioesterase OTUB1 | Medium | convergence | {"qa_id":"medium_convergence_02581","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and FOXM1 share multiple interacting partners. One such shared partner is described in literature where initial co-immunoprecipitation studies verifie... | |
medium_convergence_02583 | Human alphaherpesvirus 1 and Rhinovirus A both downregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene has a log2 fold change of approximately -1.202 and an adjusted p-value of 0.002394. Which biological process is this gene involved in? | small GTPase-mediated signal transduction | Medium | convergence | {"qa_id":"medium_convergence_02583","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rhinovirus A both downregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE114966) ind... | |
medium_convergence_02584 | RNF149 and NEDD4 both interact with a shared protein. Evidence indicates that Ndfipl binds to this shared entity and that increased expression of Ndfipl significantly reduces Itch expression. Which cell type is this shared entity enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_02584","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF149 and NEDD4 both interact with a shared protein. Evidence indicates that Ndfipl binds to this shared entity and that increased expression of Ndfipl sign... | |
medium_convergence_02585 | BMP8A and BMP6 both interact with a specific receptor. Evidence regarding one such shared receptor states: 'In addition, BMP-6 weakly bound to BMPR-IA (ALK-3), to which BMP-2 also bound.' Which disease is causally linked to this specific receptor? | CREST syndrome | Medium | convergence | {"qa_id":"medium_convergence_02585","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP8A and BMP6 both interact with a specific receptor. Evidence regarding one such shared receptor states: 'In addition, BMP-6 weakly bound to BMPR-IA (ALK-3... | |
medium_convergence_02586 | GNAI3 and ARRB1 both physically interact with a specific gene product. Experimental evidence indicates that beta-arrestin 1 physically interacts with the delta opioid receptor (DOR) in an agonist-enhanced manner, and that truncation of the carboxyl terminus of DOR partially impairs this interaction. Which protein is en... | Delta-type opioid receptor | Medium | convergence | {"qa_id":"medium_convergence_02586","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI3 and ARRB1 both physically interact with a specific gene product. Experimental evidence indicates that beta-arrestin 1 physically interacts with the del... | |
medium_convergence_02587 | MED10 and MED13 share common interaction partners. One such shared partner is identified in a study comparing MudPIT data sets from Mediator preparations immunoaffinity purified through various subunits, including Nut2 (MED10), Med25 (MED9), Intersex, LCMR1 (MED19), AK007855 (MED28), or CRSP70 (MED26). The study identi... | Mediator of RNA polymerase II transcription subunit 29 | Medium | convergence | {"qa_id":"medium_convergence_02587","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED10 and MED13 share common interaction partners. One such shared partner is identified in a study comparing MudPIT data sets from Mediator preparations imm... | |
medium_convergence_02588 | CDC7 and CDC45 both interact with a common protein substrate. Experimental evidence indicates that after reoxygenation, this specific substrate undergoes significant phosphorylation and shows increased co-immunoprecipitation with CDC7. Which gene encodes this phosphorylated substrate? | DNA replication licensing factor MCM2 | Medium | convergence | {"qa_id":"medium_convergence_02588","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC7 and CDC45 both interact with a common protein substrate. Experimental evidence indicates that after reoxygenation, this specific substrate undergoes sig... | |
medium_convergence_02589 | RACK1 (GNB2L1) and SERBP1 both interact with a shared protein. Experimental evidence involving co-immunoprecipitation and tandem mass spectrometry indicates that this shared protein forms complexes with FUS (also known as TLS or CHOP), suggesting a role for this deubiquitinating enzyme in RNA processing and cell adhesi... | Ubiquitin thioesterase OTUB1 | Medium | convergence | {"qa_id":"medium_convergence_02589","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 (GNB2L1) and SERBP1 both interact with a shared protein. Experimental evidence involving co-immunoprecipitation and tandem mass spectrometry indicates ... | |
medium_convergence_02590 | NCOR1 and NCOR2 both interact with a specific nuclear receptor. Evidence indicates that LXRs interact with corepressors N-CoR and SMRT, which are released upon binding agonists. Which protein is encoded by the gene corresponding to this LXR? | Oxysterols receptor LXR-beta | Medium | convergence | {"qa_id":"medium_convergence_02590","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOR1 and NCOR2 both interact with a specific nuclear receptor. Evidence indicates that LXRs interact with corepressors N-CoR and SMRT, which are released up... | |
medium_convergence_02591 | Osteocytes and non-terminally differentiated osteoblasts are both components of a specific anatomical structure. Evidence regarding one of these shared structures describes it as containing mature osteoblasts embedded in the bone matrix, occupying lacunae, and connected to adjacent cells via canaliculi. Which anatomica... | skeletal tissue | Medium | convergence | {"qa_id":"medium_convergence_02591","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Osteocytes and non-terminally differentiated osteoblasts are both components of a specific anatomical structure. Evidence regarding one of these shared struc... | |
medium_convergence_02592 | H3F3A and TP53 share multiple interacting partners. One such shared partner is characterized by evidence stating that it phosphorylates human p53 at Thr18 and disrupts the p53-Mdm2 interaction in vitro, although a significant decrease in p53 ubiquitination by Mdm2 in vivo was not detected. Which protein is encoded by t... | Serine/threonine-protein kinase VRK1 | Medium | convergence | {"qa_id":"medium_convergence_02592","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3F3A and TP53 share multiple interacting partners. One such shared partner is characterized by evidence stating that it phosphorylates human p53 at Thr18 an... | |
medium_convergence_02594 | CLSPN and BRIP1 both interact with a shared protein. Evidence indicates that this shared protein, when phosphorylated, interacts with Claspin and regulates its phosphorylation. Which protein is encoded by the gene corresponding to this shared entity? | Cell cycle checkpoint protein RAD17 | Medium | convergence | {"qa_id":"medium_convergence_02594","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLSPN and BRIP1 both interact with a shared protein. Evidence indicates that this shared protein, when phosphorylated, interacts with Claspin and regulates i... | |
medium_convergence_02595 | FANCD2 and FAAP100 both interact with a specific shared protein. Evidence indicates that this shared protein forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which gene does this shared protein interact with? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_02595","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FAAP100 both interact with a specific shared protein. Evidence indicates that this shared protein forms a conserved DNA-remodeling complex with th... | |
medium_convergence_02596 | EIF1AX and EIF3C each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that it interacts directly with EIF3C, EIF3G, and EIF3J via glutathione S-transferase pull-down assays. Which protein product is encoded by that shared partner? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_02596","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF1AX and EIF3C each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that it interacts directly... | |
medium_convergence_02597 | DDX17 and TOPBP1 both interact with a specific shared protein. Evidence indicates that sumoylation promotes the interaction of this shared protein and p72 with histone deacetylase 1, but has no effect on their binding to histone deacetylases 2 and 3, the coactivator p300, or estrogen receptor, nor does it affect the ho... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_02597","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX17 and TOPBP1 both interact with a specific shared protein. Evidence indicates that sumoylation promotes the interaction of this shared protein and p72 wi... | |
medium_convergence_02598 | EP300 and SIRT1 both interact with a shared protein. Evidence indicates that this shared protein can directly deacetylate SREBP, and that modulating its activity alters SREBP ubiquitination, protein stability, and target gene expression. Which protein is encoded by the gene corresponding to this shared entity? | Sterol regulatory element-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02598","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SIRT1 both interact with a shared protein. Evidence indicates that this shared protein can directly deacetylate SREBP, and that modulating its acti... | |
medium_convergence_02599 | HIST1H2BB and HIST2H3A share common interacting partners. One such shared partner is characterized by evidence showing that its purified PHD finger or full-length protein monoubiquitinates H2BK120 in vitro, and that loss of this entity drastically reduces H2BK120Ub genome-wide binding sites in MCF10A cells. Which prote... | Putative E3 ubiquitin-protein ligase UBR7 | Medium | convergence | {"qa_id":"medium_convergence_02599","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST1H2BB and HIST2H3A share common interacting partners. One such shared partner is characterized by evidence showing that its purified PHD finger or full-l... | |
medium_convergence_02600 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.278 and an adjusted p-value of 6.018e-07. Which disease is as... | leukemia | Medium | convergence | {"qa_id":"medium_convergence_02600","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data f... | |
medium_convergence_02601 | GNAI3 and GNB2 each interact with more than one shared G-protein gamma subunit. Evidence concerning one of these shared entities states: 'The gamma 10 is modified by a geranylgeranyl group and is capable of interacting with beta 1 and beta 2 but not with beta 3.' Which protein is encoded by the gene corresponding to th... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | Medium | convergence | {"qa_id":"medium_convergence_02601","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI3 and GNB2 each interact with more than one shared G-protein gamma subunit. Evidence concerning one of these shared entities states: 'The gamma 10 is mod... | |
medium_convergence_02602 | ARRB1 and ARRB2 both interact with a shared protein entity. Evidence regarding this entity states: 'We show that beta arrestin 1 and beta arrestin 2 associate with [MAPK10] via the kinase N-terminal domain in a region that, surprisingly, does not harbour a known common docking motif.' Which disease is connected to this... | microphthalmia | Medium | convergence | {"qa_id":"medium_convergence_02602","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB1 and ARRB2 both interact with a shared protein entity. Evidence regarding this entity states: 'We show that beta arrestin 1 and beta arrestin 2 associat... | |
medium_convergence_02603 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Evidence for this gene in a study (GSE11238) reports a log2 fold change of -3.826 and an adjusted p-value of 0.02704. Which cell type is this gene enriched in? | memory B cell | Medium | convergence | {"qa_id":"medium_convergence_02603","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Evidence for this gene in a study (GSE11238) reports a log2 fold change of -3.826... | |
medium_convergence_02604 | Both Hepacivirus C and Zaire ebolavirus are known to upregulate a specific gene. Experimental data for this gene, derived from peripheral blood mononuclear cells, shows a log2 fold change of approximately 1.675 and an adjusted p-value of 1.259e-06. Which biological process is this gene involved in? | protein localization to Golgi membrane | Medium | convergence | {"qa_id":"medium_convergence_02604","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are known to upregulate a specific gene. Experimental data for this gene, derived from peripheral blood mononuclear c... | |
medium_convergence_02606 | Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) reports a log2 fold change of approximately 1.807 and an adjusted p-value of 0.03331. Which protein does this gene product bind to? | MT-ATP8 | Medium | convergence | {"qa_id":"medium_convergence_02606","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study ... | |
medium_convergence_02608 | HSCB and DLAT each interact with more than one shared protein. Evidence concerning one of these shared entities reports that its binding with PDK2 was readily reversible, with an apparent dissociation constant of approximately 10 microM for both isoenzymes. Which protein is connected to that entity through the 'encodes... | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_02608","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSCB and DLAT each interact with more than one shared protein. Evidence concerning one of these shared entities reports that its binding with PDK2 was readil... | |
medium_convergence_02609 | Both IRF3 and CD14 interact with a shared protein. Evidence regarding this shared protein states: 'While IRF-7 DN had no effect on virus-stimulated nuclear translocation of IRF-3 and IRF-7, the binding of IRF-7 DN to IRF-3 and IRF-7 was detected by GST pull-down assay as well as by immunoprecipitation in infected cells... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02609","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IRF3 and CD14 interact with a shared protein. Evidence regarding this shared protein states: 'While IRF-7 DN had no effect on virus-stimulated nuclear t... | |
medium_convergence_02610 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.13 and an adjusted p-value of 0.000465. Which protein is encoded by... | Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 | Medium | convergence | {"qa_id":"medium_convergence_02610","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for t... | |
medium_convergence_02611 | TUBA1B and TUBB4B both interact with a shared protein. Experimental evidence involving microtubule sedimentation and cryo-electron microscopy with 3D reconstruction indicates that the basic N-terminal domain of this shared protein mediates its binding to the acidic C-terminal tails of α- and β-tubulin on the microtubul... | Echinoderm microtubule-associated protein-like 4 | Medium | convergence | {"qa_id":"medium_convergence_02611","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TUBA1B and TUBB4B both interact with a shared protein. Experimental evidence involving microtubule sedimentation and cryo-electron microscopy with 3D reconst... | |
medium_convergence_02612 | TRIM28 and TOPBP1 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, histone deacetylases HDAC1/2, and the histone methyltransferase G9a/GLP, and modulates the interaction of HDAC1 and KAP1 with heterochromatin. Which cell type is ... | basophil | Medium | convergence | {"qa_id":"medium_convergence_02612","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and TOPBP1 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1,... | |
medium_convergence_02613 | ATM and HIST1H4A share a common interacting partner. Evidence regarding this partner states: 'We report here that [the partner] physically associates with ATM, p53, components of the MRE11-RAD50-NBS1 (MRN) complex, and gamma-H2AX.' Which disease is associated with this shared entity? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_02613","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and HIST1H4A share a common interacting partner. Evidence regarding this partner states: 'We report here that [the partner] physically associates with AT... | |
medium_convergence_02614 | DLG4 and GRIN2B share multiple interacting partners. One such partner is described in the following evidence: 'Here we show that NR2B, but not NR2A or NR1 subunits of the NMDAR, interacts in vivo and in vitro with this entity, a Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor.' What molecular functi... | guanyl-nucleotide exchange factor activity | Medium | convergence | {"qa_id":"medium_convergence_02614","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and GRIN2B share multiple interacting partners. One such partner is described in the following evidence: 'Here we show that NR2B, but not NR2A or NR1 su... | |
medium_convergence_02615 | Human gammaherpesvirus 4 and Zika virus both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) shows a log2 fold change of approximately -1.232 and an adjusted p-value of 0.03513. Which protein is encoded by this gene? | Vacuolar protein sorting-associated protein 37B | Medium | convergence | {"qa_id":"medium_convergence_02615","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Zika virus both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906)... | |
medium_convergence_02616 | Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are reported to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene showed a log2 fold change of approximately 3.05 and an adjusted p-value of approximately 0.007. Which protein is encoded by this gene? | Serine/threonine-protein kinase greatwall | Medium | convergence | {"qa_id":"medium_convergence_02616","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are reported to upregulate a specific gene. In a study using a monocytic leukemia cell line (... | |
medium_convergence_02617 | SYNCRIP and EWSR1 share multiple interacting partners. One such shared partner is distinguished by evidence stating: 'The interaction between this protein and the EWS protein was characterized in more detail.' Which protein is encoded by this specific shared partner? | Protein arginine N-methyltransferase 8 | Medium | convergence | {"qa_id":"medium_convergence_02617","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SYNCRIP and EWSR1 share multiple interacting partners. One such shared partner is distinguished by evidence stating: 'The interaction between this protein an... | |
medium_convergence_02619 | NKX2-5 and GATA4 share multiple interacting partners. One such shared partner is reported to physically associate with both NKX2-5 and GATA4 in vitro and in vivo, as demonstrated by glutathione S-transferase pull-down and immunoprecipitation assays. Which gene interacts with this specific shared partner? | SETDB1 | Medium | convergence | {"qa_id":"medium_convergence_02619","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NKX2-5 and GATA4 share multiple interacting partners. One such shared partner is reported to physically associate with both NKX2-5 and GATA4 in vitro and in ... | |
medium_convergence_02620 | Both 'regulation of hair follicle maturation' and 'regulation of stem cell population maintenance' are subtypes of a shared biological process. Evidence regarding one of these shared processes states: 'Any process that modulates the frequency, rate or extent of hair follicle maturation.' Which biological process is the... | multicellular organismal process | Medium | convergence | {"qa_id":"medium_convergence_02620","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of hair follicle maturation' and 'regulation of stem cell population maintenance' are subtypes of a shared biological process. Evidence rega... | |
medium_convergence_02621 | SAP18 and SIN3A each interact with more than one shared gene. Evidence concerning one shared entity reports that a specific protein is identical to mSDS3, the human ortholog of the SDS3p component of the Saccharomyces cerevisiae Sin3p-Rpd3p corepressor complex. Which gene is connected to that entity through a binding i... | USP17L2 | Medium | convergence | {"qa_id":"medium_convergence_02621","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SAP18 and SIN3A each interact with more than one shared gene. Evidence concerning one shared entity reports that a specific protein is identical to mSDS3, th... | |
medium_convergence_02622 | MAVS and UBE2D3 share common interaction partners. One such partner is known to bind MAVS within the mitochondrial compartment following viral infection, where it negatively regulates RIG-I-like receptor (RLR)-mediated antiviral immunity. Which protein is encoded by this specific interaction partner? | E3 ubiquitin-protein ligase RNF34 | Medium | convergence | {"qa_id":"medium_convergence_02622","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAVS and UBE2D3 share common interaction partners. One such partner is known to bind MAVS within the mitochondrial compartment following viral infection, whe... | |
medium_convergence_02624 | COPS5 and HSPA1A share a common interacting partner. Experimental evidence indicates that the SH3 domain of this shared partner directly binds to the MPN domain of COPS5 in a GST pull-down assay. Which disease is associated with this shared partner as a biomarker? | retinoblastoma | Medium | convergence | {"qa_id":"medium_convergence_02624","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and HSPA1A share a common interacting partner. Experimental evidence indicates that the SH3 domain of this shared partner directly binds to the MPN dom... | |
medium_convergence_02625 | CHD4 and SOX2 share multiple interacting partners. One such shared partner is described in the evidence as interacting with CHD4, which is identified as a core member of the nucleosome remodeling and deacetylase (NuRD) complex. Which disease is associated with this specific shared partner? | glioma | Medium | convergence | {"qa_id":"medium_convergence_02625","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and SOX2 share multiple interacting partners. One such shared partner is described in the evidence as interacting with CHD4, which is identified as a co... | |
medium_convergence_02626 | SMAD2 and TEAD4 both interact with a specific transcriptional coactivator. Evidence indicates that the interaction between IRF2BP2 and VGLL4 enhances the binding of TEAD4 to this coactivator, leading to the transcriptional coactivation of CTGF. Which protein encodes this coactivator? | Transcriptional coactivator YAP1 | Medium | convergence | {"qa_id":"medium_convergence_02626","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD2 and TEAD4 both interact with a specific transcriptional coactivator. Evidence indicates that the interaction between IRF2BP2 and VGLL4 enhances the bin... | |
medium_convergence_02627 | KCNA3 and MYC share a common interacting partner. Evidence indicates that Kv1.3 forms a complex with this shared partner in the nucleus. Which gene interacts with this shared partner? | RUNX2 | Medium | convergence | {"qa_id":"medium_convergence_02627","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNA3 and MYC share a common interacting partner. Evidence indicates that Kv1.3 forms a complex with this shared partner in the nucleus. Which gene interacts... | |
medium_convergence_02628 | EZH2 and HIST2H3A share multiple binding partners. One of these shared partners is described by the evidence: 'We found that this protein associates with PRC2 and stimulates its enzymatic activity in vitro.' What molecular function is enabled by this specific shared partner? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02628","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and HIST2H3A share multiple binding partners. One of these shared partners is described by the evidence: 'We found that this protein associates with PRC... | |
medium_convergence_02629 | TOPBP1 and PML share common interaction partners. One such shared partner has been experimentally shown to directly interact with the promyelocytic leukemia (PML) protein in response to radiation. Which disease is associated with this specific shared partner? | pancreatic ductal adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_02629","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and PML share common interaction partners. One such shared partner has been experimentally shown to directly interact with the promyelocytic leukemia ... | |
medium_convergence_02630 | FANCA and FANCB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which disease is associated with this specific protein p... | multiple evanescent white dot syndrome | Medium | convergence | {"qa_id":"medium_convergence_02630","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FANCB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The N terminus appears to stabi... | |
medium_convergence_02631 | Interferon alfacon-1 and Rituximab both interact with a specific shared drug. Clinical evidence indicates that adding this shared drug to etoposide and the drug itself improves CD34+ cell yield (9.9 vs 5.6 × 10^6/kg; P = .021). Which disease is this shared drug indicated for? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_02631","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon alfacon-1 and Rituximab both interact with a specific shared drug. Clinical evidence indicates that adding this shared drug to etoposide and the d... | |
medium_convergence_02632 | Dexbrompheniramine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect, this shared drug enhanced the anticonvulsive action of most benzodiazepines tested. Which disease is this shared drug indicated for? | anxiety | Medium | convergence | {"qa_id":"medium_convergence_02632","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dexbrompheniramine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no ... | |
medium_convergence_02633 | DYRK1A and PFN1 each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'These proteins had a proline-rich domain and directly interacted with profilin.' Which protein is encoded by the gene corresponding to that entity? | Protein enabled homolog | Medium | convergence | {"qa_id":"medium_convergence_02633","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYRK1A and PFN1 each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'These proteins had a proline-... | |
medium_convergence_02635 | GABARAPL2 and MAP1LC3C share multiple interacting partners. One of these shared partners is characterized by evidence showing it binds ATG8 family proteins, with a preference for LC3C, and directly interacts with SOD1. Which disease is associated with this specific entity via genomic alterations? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02635","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABARAPL2 and MAP1LC3C share multiple interacting partners. One of these shared partners is characterized by evidence showing it binds ATG8 family proteins, ... | |
medium_convergence_02636 | EIF1AX and EIF3J each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is connected to that entity through the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_02636","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF1AX and EIF3J each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and... | |
medium_convergence_02637 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 3.48 and an adjusted p-value of approximately 0.031. Which d... | adult lymphoma | Medium | convergence | {"qa_id":"medium_convergence_02637","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_02638 | STUB1 and HIF1A share multiple interacting partners. One such shared partner is described by the following evidence: 'Here, we demonstrate that the protein itself interacts with HIF-1α, prolyl hydroxylase (PHD) and VHL to promote degradation of HIF-1α via the proteasomal pathway independent of lipase activity.' Which d... | neuroblastoma | Medium | convergence | {"qa_id":"medium_convergence_02638","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HIF1A share multiple interacting partners. One such shared partner is described by the following evidence: 'Here, we demonstrate that the protein i... | |
medium_convergence_02639 | CDKN1C and EP300 both interact with a specific shared protein. Experimental evidence for this shared protein indicates that no in vivo interaction was found with either p21(Waf1/Cip1) or p27(KIP1), but binding to p57(KIP2) was readily detectable in both in vivo and in vitro assays. Which protein is encoded by this shar... | Myb-related protein B | Medium | convergence | {"qa_id":"medium_convergence_02639","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1C and EP300 both interact with a specific shared protein. Experimental evidence for this shared protein indicates that no in vivo interaction was found ... |
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