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medium_convergence_03523 | KAT5 and ELAVL1 share multiple interacting partners. One such shared partner is a protein that interacts directly with the chromatin remodeling protein Tip60, as demonstrated in a yeast two-hybrid system. Which protein is encoded by the gene corresponding to this shared partner? | Fanconi anemia group D2 protein | Medium | convergence | {"qa_id":"medium_convergence_03523","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and ELAVL1 share multiple interacting partners. One such shared partner is a protein that interacts directly with the chromatin remodeling protein Tip60... | |
medium_convergence_03524 | SMAD4 and BMP2 both interact with a common protein. Evidence indicates that TRIP12 recruits this common protein to SMAD4, a process likely responsible for the inhibitory monoubiquitination of SMAD4, as SMAD4 monoubiquitination and its interaction with this protein are significantly reduced in the absence of TRIP12. Whi... | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_03524","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD4 and BMP2 both interact with a common protein. Evidence indicates that TRIP12 recruits this common protein to SMAD4, a process likely responsible for th... | |
medium_convergence_03525 | CENPA and CENPI each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which disease is connected to this protein through... | glioma | Medium | convergence | {"qa_id":"medium_convergence_03525","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPI each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_03526 | CDCA5 and BIRC5 share a common binding partner. Evidence regarding one such partner states: 'Approximately half of Aurora B in mitotic cells is complexed with INCENP, a CDCA8 protein, and Survivin; and the CDCA8 protein binds Survivin and INCENP in vitro.' Which disease is associated with this specific shared partner v... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_03526","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDCA5 and BIRC5 share a common binding partner. Evidence regarding one such partner states: 'Approximately half of Aurora B in mitotic cells is complexed wit... | |
medium_convergence_03527 | DAXX and FADD both interact with a common protein. Evidence indicates that this shared protein can interact with caspase-8 and FADD both in vivo and in vitro. Which protein is encoded by the gene corresponding to this shared entity? | FAS-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03527","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and FADD both interact with a common protein. Evidence indicates that this shared protein can interact with caspase-8 and FADD both in vivo and in vitro... | |
medium_convergence_03528 | ESR1 and POLR2J share multiple interacting partners. One such partner is described in evidence stating: 'We present evidence that DRIP205 interacts with another member of the steroid receptor subfamily, estrogen receptor (ER).' Which protein product is encoded by this specific shared interacting partner? | Mediator of RNA polymerase II transcription subunit 14 | Medium | convergence | {"qa_id":"medium_convergence_03528","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and POLR2J share multiple interacting partners. One such partner is described in evidence stating: 'We present evidence that DRIP205 interacts with anot... | |
medium_convergence_03529 | VAMP5 and VTI1A both interact with a shared gene product. Evidence indicates that this shared entity forms a complex with syntaxin 7, vti1b, and endobrevin/VAMP-8, functioning in the fusion of late endosomes. Which gene does this shared entity interact with? | CDC42 | Medium | convergence | {"qa_id":"medium_convergence_03529","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VAMP5 and VTI1A both interact with a shared gene product. Evidence indicates that this shared entity forms a complex with syntaxin 7, vti1b, and endobrevin/V... | |
medium_convergence_03530 | Both the regulation of neutrophil degranulation and the regulation of basophil degranulation are subtypes of a shared biological process. Evidence for this shared process states: 'Any process that modulates the frequency, rate, or extent of neutrophil degranulation.' Which biological process is directly regulated by th... | leukocyte degranulation | Medium | convergence | {"qa_id":"medium_convergence_03530","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of neutrophil degranulation and the regulation of basophil degranulation are subtypes of a shared biological process. Evidence for this s... | |
medium_convergence_03532 | LMO2 and CBFB both interact with a shared transcription factor. Evidence regarding this shared entity states: 'We report the 2.6 A resolution crystal structure of the complex between the [RUNX1] Runt domain and CBFbeta, which represents a paradigm for the mode of interaction of this highly conserved family of transcrip... | Runt-related transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03532","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LMO2 and CBFB both interact with a shared transcription factor. Evidence regarding this shared entity states: 'We report the 2.6 A resolution crystal structu... | |
medium_convergence_03533 | ESR1 and PES1 share multiple interacting partners. One such shared partner is described as interacting specifically with PES1 and Bop1, yet fulfilling critical functions for the proper 3' end formation of 47S rRNA independently of the PeBoW complex. Which biological process is this specific shared partner involved in? | rRNA processing | Medium | convergence | {"qa_id":"medium_convergence_03533","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and PES1 share multiple interacting partners. One such shared partner is described as interacting specifically with PES1 and Bop1, yet fulfilling critic... | |
medium_convergence_03535 | CLNS1A and PRMT1 both interact with a specific shared protein. Experimental evidence indicates that for this shared entity, JBP1 binds SmD1 and SmD3 via their RG domains, while pICln binds the Sm domains. Which protein is encoded by this shared entity? | Small nuclear ribonucleoprotein-associated proteins B and B' | Medium | convergence | {"qa_id":"medium_convergence_03535","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLNS1A and PRMT1 both interact with a specific shared protein. Experimental evidence indicates that for this shared entity, JBP1 binds SmD1 and SmD3 via thei... | |
medium_convergence_03536 | WWP2 and NEDD4 both interact with a specific shared protein. Evidence indicates that for this shared protein, ubiquitination and PPXY motifs mediate its degradation, dictate its subcellular localization, and are required for its interaction with the NEDD4-family E3 ubiquitin ligase WWP2. Which gene encodes this shared ... | Arrestin domain-containing protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03536","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP2 and NEDD4 both interact with a specific shared protein. Evidence indicates that for this shared protein, ubiquitination and PPXY motifs mediate its degr... | |
medium_convergence_03537 | EGFR and TRAF6 share common interacting partners. One such partner is identified in a study where additional protein interaction characterization revealed epidermal growth factor receptor (EGFR) as a novel interacting partner for a receptor encoded by TNFRSF11A in breast cancer cells, exerting a negative effect on EGFR... | Tumor necrosis factor receptor superfamily member 11A | Medium | convergence | {"qa_id":"medium_convergence_03537","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and TRAF6 share common interacting partners. One such partner is identified in a study where additional protein interaction characterization revealed ep... | |
medium_convergence_03538 | CDC37 and FKBP5 both interact with a specific shared protein. Evidence indicates that this protein, referred to as p50, interacts with nascent EIF2AK1 co-translationally, and this interaction persists during the maturation and activation of EIF2AK1. In which cellular component is this protein located? | cytosol | Medium | convergence | {"qa_id":"medium_convergence_03538","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and FKBP5 both interact with a specific shared protein. Evidence indicates that this protein, referred to as p50, interacts with nascent EIF2AK1 co-tra... | |
medium_convergence_03539 | FEN1 and MSH6 share a common interacting partner. Experimental evidence indicates that this shared partner and FEN-1 are associated in human nuclei, as demonstrated by their reciprocal co-immunoprecipitation from HeLa nuclear extracts. Which protein is encoded by the gene corresponding to this shared partner? | RecQ-like DNA helicase BLM | Medium | convergence | {"qa_id":"medium_convergence_03539","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FEN1 and MSH6 share a common interacting partner. Experimental evidence indicates that this shared partner and FEN-1 are associated in human nuclei, as demon... | |
medium_convergence_03540 | CBX8 and UBE2D3 both interact with a shared protein partner. Evidence regarding one such partner states: 'The structure of a high-activity variant in complex with E2 (the shared partner-RING1B-UbcH5c) reveals only subtle differences from an earlier PCGF4 complex structure.' Which protein is encoded by this shared partn... | Polycomb group RING finger protein 5 | Medium | convergence | {"qa_id":"medium_convergence_03540","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX8 and UBE2D3 both interact with a shared protein partner. Evidence regarding one such partner states: 'The structure of a high-activity variant in complex... | |
medium_convergence_03541 | NUB1 and PSMA4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which disease is ass... | plasma cell myeloma | Medium | convergence | {"qa_id":"medium_convergence_03541","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUB1 and PSMA4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In the present study, we de... | |
medium_convergence_03542 | DAXX and EZH2 both interact with a specific protein that is a subunit of the Polycomb Repressive Complex 2 (PRC2). Experimental evidence indicates that label-free quantitative proteomics was utilized to assess the endogenous immunoprecipitation of this protein alongside EZH2 within the PRC2 complex. Which protein is en... | Polycomb protein SUZ12 | Medium | convergence | {"qa_id":"medium_convergence_03542","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and EZH2 both interact with a specific protein that is a subunit of the Polycomb Repressive Complex 2 (PRC2). Experimental evidence indicates that label... | |
medium_convergence_03543 | CREBBP and ARID1A each interact with more than one shared gene product. Evidence concerning one shared entity reports that phosphorylation of this entity induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein. Which disease is connected to that entity through... | primary effusion lymphoma | Medium | convergence | {"qa_id":"medium_convergence_03543","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and ARID1A each interact with more than one shared gene product. Evidence concerning one shared entity reports that phosphorylation of this entity ind... | |
medium_convergence_03545 | COPB1 and COG3 share a common interacting partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which disease is associated with this shared interacting ... | neutropenia, severe congenital, 12, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_03545","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and COG3 share a common interacting partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisti... | |
medium_convergence_03546 | CUL1 and CDC16 both interact with a specific protein. Evidence regarding this protein states: 'Here we identify human CUL-1, a member of the cullin family, and the ubiquitin-conjugating enzyme CDC34 as additional partners of the target protein in vivo.' Which protein is encoded by the gene corresponding to this interac... | S-phase kinase-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03546","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL1 and CDC16 both interact with a specific protein. Evidence regarding this protein states: 'Here we identify human CUL-1, a member of the cullin family, a... | |
medium_convergence_03547 | SALL1 and PAX8 are both involved in multiple shared biological processes. One of these shared processes is associated with an entity known to be expressed in the developing central nervous system and kidney, specifically including the ureteric bud and the main collecting ducts. Which biological process is this shared e... | renal system development | Medium | convergence | {"qa_id":"medium_convergence_03547","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SALL1 and PAX8 are both involved in multiple shared biological processes. One of these shared processes is associated with an entity known to be expressed in... | |
medium_convergence_03548 | BIRC5 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protein, CDC20, and MAD2 in near equal stoichiometry. Which disease is associated with this shared protein? | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_03548","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC5 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protein,... | |
medium_convergence_03549 | Human betaherpesvirus 5 and West Nile virus both upregulate a specific gene in dendritic cells. Experimental data from study GSE101855 indicates that for one such shared target, the log2 fold change is approximately 3.016 and the adjusted p-value is 0.007737. Which protein is encoded by this specific gene? | Tumor necrosis factor-inducible gene 6 protein | Medium | convergence | {"qa_id":"medium_convergence_03549","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and West Nile virus both upregulate a specific gene in dendritic cells. Experimental data from study GSE101855 indicates that for one... | |
medium_convergence_03550 | YAP1 and AR share multiple interacting partners. One such shared partner is described in experimental evidence stating: 'In co-immunoprecipitation assays, we discover that this protein physically associated with YAP/TAZ and furthermore disrupts the interaction between YAP and β-TrCP E3 ubiquitin ligase, which promotes ... | CCNF | Medium | convergence | {"qa_id":"medium_convergence_03550","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and AR share multiple interacting partners. One such shared partner is described in experimental evidence stating: 'In co-immunoprecipitation assays, we... | |
medium_convergence_03552 | Histamine secretion by mast cells and histamine secretion by platelets share multiple upstream biological processes. One such shared process is defined by the evidence: 'The regulated release of histamine by a mast cell or group of mast cells.' Which biological process is this shared entity a part of? | exocytosis | Medium | convergence | {"qa_id":"medium_convergence_03552","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Histamine secretion by mast cells and histamine secretion by platelets share multiple upstream biological processes. One such shared process is defined by th... | |
medium_convergence_03553 | DMD and AGRN each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Yeast two-hybrid analyses and binding assays using recombinant proteins demonstrated direct interaction involving coiled-coil-forming regions in both dysbindin and the dystrobrevins. Which... | Dystrobrevin beta | Medium | convergence | {"qa_id":"medium_convergence_03553","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMD and AGRN each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Yeast two-hybrid analyses... | |
medium_convergence_03554 | NFKB1 and RELA each interact with more than one shared gene. Evidence concerning one shared entity reports that its isoforms are additionally shown to interact directly with RelA, p50, and several subunits of the SWI/SNF complex in vitro and to be co-immunoprecipitated with RelA/p50 and the SWI/SNF complex from the nuc... | male infertility | Medium | convergence | {"qa_id":"medium_convergence_03554","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB1 and RELA each interact with more than one shared gene. Evidence concerning one shared entity reports that its isoforms are additionally shown to intera... | |
medium_convergence_03555 | ERCC4 and FANCD2 both interact with a shared protein partner. Evidence indicates that the direct interaction between this shared partner and FANCD2 was demonstrated in the yeast two-hybrid system. Which protein is encoded by this shared partner? | Fanconi anemia group E protein | Medium | convergence | {"qa_id":"medium_convergence_03555","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and FANCD2 both interact with a shared protein partner. Evidence indicates that the direct interaction between this shared partner and FANCD2 was demon... | |
medium_convergence_03556 | Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific host gene. Experimental data for this gene reports a log2 fold change of approximately 2.73 and an adjusted p-value of approximately 0.00075. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03556","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific host gene. Experimental data for this gene reports a log2 fol... | |
medium_convergence_03557 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene has a log2 fold change of -1.257 and an adjusted p-value of 0.04049. Which protein does this gene product bind to? | CFI | Medium | convergence | {"qa_id":"medium_convergence_03557","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_03558 | DMAP1 and EP400 both interact with a specific shared protein. Biochemical evidence from the purification of this protein and its associated partners from HeLa cell nuclear extracts identifies the thyroid receptor coactivating protein (TRCp120), the shared protein itself, and the related MRG15 and MRGX proteins as compo... | MRG/MORF4L-binding protein | Medium | convergence | {"qa_id":"medium_convergence_03558","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMAP1 and EP400 both interact with a specific shared protein. Biochemical evidence from the purification of this protein and its associated partners from HeL... | |
medium_convergence_03559 | RHOA and RHOB each interact with more than one shared gene product. Evidence concerning one shared entity reports that a specific protein preferentially associates with that entity. Which protein is encoded by that entity? | Rho guanine nucleotide exchange factor 3 | Medium | convergence | {"qa_id":"medium_convergence_03559","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and RHOB each interact with more than one shared gene product. Evidence concerning one shared entity reports that a specific protein preferentially asso... | |
medium_convergence_03560 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a study on hepatocytes (GSE135619) indicates that this gene exhibits a log2 fold change of approximately -1.358 and an adjusted p-value of 0.02629. Which prot... | Delta(24)-sterol reductase | Medium | convergence | {"qa_id":"medium_convergence_03560","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_03561 | PIK3CG and CD80 share a common binding partner. Evidence regarding this shared entity states: 'Like p101, p87(PIKAP) binds to both p110gamma and Gbetagamma and mediates activation of p110gamma downstream of G protein-coupled receptors.' Which protein is encoded by this shared entity? | Phosphoinositide 3-kinase regulatory subunit 6 | Medium | convergence | {"qa_id":"medium_convergence_03561","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIK3CG and CD80 share a common binding partner. Evidence regarding this shared entity states: 'Like p101, p87(PIKAP) binds to both p110gamma and Gbetagamma a... | |
medium_convergence_03562 | PSMA5 and PSMB2 both interact with a common protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subunit beta2 is required for beta2's interaction with adjacent beta3, whereas the C-terminal extension of immunosubunit beta2i is dispensable for beta2i's interaction ... | Proteasome subunit beta type-3 | Medium | convergence | {"qa_id":"medium_convergence_03562","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA5 and PSMB2 both interact with a common protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subun... | |
medium_convergence_03563 | UBQLN1 and HSPA5 both interact with a shared protein. Evidence indicates that this shared protein mediates the interaction between UBQLN1 and the autophagy machinery by recruiting UBQLN1 to LC3. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquilin-4 | Medium | convergence | {"qa_id":"medium_convergence_03563","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBQLN1 and HSPA5 both interact with a shared protein. Evidence indicates that this shared protein mediates the interaction between UBQLN1 and the autophagy m... | |
medium_convergence_03564 | YAP1 and HSPB1 share multiple interacting partners. One such partner is described in evidence stating that a kinase physically interacts with YAP and counteracts CK1δ/ε-mediated YAP ubiquitination and degradation independent of LATS1/2. Which protein is encoded by the gene corresponding to this interacting partner? | MAP kinase-activated protein kinase 5 | Medium | convergence | {"qa_id":"medium_convergence_03564","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and HSPB1 share multiple interacting partners. One such partner is described in evidence stating that a kinase physically interacts with YAP and counter... | |
medium_convergence_03565 | CDH3 and CDH15 both interact with a common protein partner. A study reports that wild-type CAS associates with N-cadherin (CDH2) and P-cadherin (CDH3), in addition to E-cadherin. Which protein, encoded by the gene connected to this shared partner via an 'encodes' relationship, is the subject of this interaction context... | Catenin delta-1 | Medium | convergence | {"qa_id":"medium_convergence_03565","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH3 and CDH15 both interact with a common protein partner. A study reports that wild-type CAS associates with N-cadherin (CDH2) and P-cadherin (CDH3), in ad... | |
medium_convergence_03566 | BMAL1 and BTRC each interact with more than one shared protein. Evidence concerning one of these shared entities reports that SUMO2 conjugation facilitated its interaction with β-TrCP, leading to its proteasomal degradation. Which protein is connected to that entity through the 'encodes' relationship? | Period circadian protein homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_03566","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMAL1 and BTRC each interact with more than one shared protein. Evidence concerning one of these shared entities reports that SUMO2 conjugation facilitated i... | |
medium_convergence_03568 | AGR2 and CBX3 both interact with a shared protein. Evidence regarding this shared protein states: 'We also determined the crystal structures of the human Cbx3 chromodomain in complex with dimethylated histone H1K26 and trimethylated G9aK185 peptides, respectively.' Which cell type is enriched in this shared protein? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03568","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGR2 and CBX3 both interact with a shared protein. Evidence regarding this shared protein states: 'We also determined the crystal structures of the human Cbx... | |
medium_convergence_03569 | CRK and CRKL each interact with more than one shared gene product. Evidence concerning one shared entity reports that a specific E3 ubiquitin-protein ligase constitutively binds Grb2 and becomes associated with Crk-L upon TCR stimulation. Which protein is encoded by that entity? | E3 ubiquitin-protein ligase CBL-B | Medium | convergence | {"qa_id":"medium_convergence_03569","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and CRKL each interact with more than one shared gene product. Evidence concerning one shared entity reports that a specific E3 ubiquitin-protein ligase ... | |
medium_convergence_03570 | EGFR and ERBB2 share interaction partners. One such partner is described in a study where the c-erbB-2 gene product was shown by far-Western blotting to associate directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region, which shares extensive homology with the epidermal growth factor ... | Junction plakoglobin | Medium | convergence | {"qa_id":"medium_convergence_03570","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB2 share interaction partners. One such partner is described in a study where the c-erbB-2 gene product was shown by far-Western blotting to asso... | |
medium_convergence_03571 | MAP3K11 and MAP2K7 both interact with a common protein target. Experimental evidence indicates that MKK7 phosphorylates and activates a specific MAP kinase, but does not activate the p38 or extracellular signal-regulated kinase groups of MAP kinases. Which protein is encoded by the gene corresponding to this common tar... | Mitogen-activated protein kinase 8 | Medium | convergence | {"qa_id":"medium_convergence_03571","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP3K11 and MAP2K7 both interact with a common protein target. Experimental evidence indicates that MKK7 phosphorylates and activates a specific MAP kinase, ... | |
medium_convergence_03572 | C8A and C9 each interact with more than one shared protein. Evidence concerning one shared entity reports that it bound specifically to all peptides starting N-terminal to C9 residue 359 with C termini extending beyond residue 411. Which protein is connected to that entity through encodes? | CD59 glycoprotein | Medium | convergence | {"qa_id":"medium_convergence_03572","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C8A and C9 each interact with more than one shared protein. Evidence concerning one shared entity reports that it bound specifically to all peptides starting... | |
medium_convergence_03573 | FOXE3 and PAX6 are both involved in multiple shared biological processes. One such shared process involves a lens-specific transcription factor associated with anterior segment ocular dysgenesis. Which anatomical structure is the result of the development governed by this specific shared process? | eye | Medium | convergence | {"qa_id":"medium_convergence_03573","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXE3 and PAX6 are both involved in multiple shared biological processes. One such shared process involves a lens-specific transcription factor associated wi... | |
medium_convergence_03574 | SAR1B and INSIG2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'This paper describes insig-2, a second protein of the endoplasmic reticulum that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to the shared entity (SREBP cleavage-acti... | Sterol regulatory element-binding protein cleavage-activating protein | Medium | convergence | {"qa_id":"medium_convergence_03574","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SAR1B and INSIG2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'This paper describes insig-2, a second protein ... | |
medium_convergence_03575 | CBFB and ASH2L both interact with a specific shared protein. Evidence regarding this shared entity states: 'We report the 2.6 A resolution crystal structure of the complex between the Runt domain of a transcription factor and CBFbeta, which represents a paradigm for the mode of interaction of this highly conserved fami... | Runt-related transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03575","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBFB and ASH2L both interact with a specific shared protein. Evidence regarding this shared entity states: 'We report the 2.6 A resolution crystal structure ... | |
medium_convergence_03576 | CSNK2A1 and FBXW11 share a common interacting partner. Experimental evidence indicates that this partner, identified as hnRNP A2, associates with both catalytic and regulatory subunits of the CK2 holoenzyme in binding assays, an interaction that is independent of RNA presence. Which disease is linked to this specific i... | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_03576","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and FBXW11 share a common interacting partner. Experimental evidence indicates that this partner, identified as hnRNP A2, associates with both cataly... | |
medium_convergence_03577 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of -2.036 and an adjusted p-value of 4.877e-07. Which prot... | Ribosome biogenesis regulatory protein homolog | Medium | convergence | {"qa_id":"medium_convergence_03577","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experiment... | |
medium_convergence_03578 | Androgen receptor (AR) and Polo-like kinase 1 (PLK1) both interact with a specific shared protein. Experimental evidence, including far-Western blotting and co-immunoprecipitation assays, demonstrates that this shared protein interacts directly with the protein encoded by the TMF1 gene. Which protein is encoded by this... | TATA element modulatory factor | Medium | convergence | {"qa_id":"medium_convergence_03578","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Androgen receptor (AR) and Polo-like kinase 1 (PLK1) both interact with a specific shared protein. Experimental evidence, including far-Western blotting and ... | |
medium_convergence_03579 | CDH2 and ACTR2 both interact with a shared protein partner. Evidence regarding this partner states: 'In one, the transmembrane glycoproteins N-cadherin and cadherin-11 [which also occur in heterotypic ('mixed') complexes] are associated with alpha- and beta-catenin, plakoglobin (proportions variable among species), p12... | Catenin alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_03579","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH2 and ACTR2 both interact with a shared protein partner. Evidence regarding this partner states: 'In one, the transmembrane glycoproteins N-cadherin and c... | |
medium_convergence_03580 | Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for one such shared target reports a log2 fold change of 1.109 and an adjusted p-value of 0.03026. Which disease is associated with this gene through genomic alterations? | lung neoplasm | Medium | convergence | {"qa_id":"medium_convergence_03580","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for one such shared target reports a log2 fold change of 1.109 and an adj... | |
medium_convergence_03581 | CENPA and HJURP both interact with a shared protein partner. Evidence indicates that this partner is recruited to centromeres through a direct interaction between its centromere targeting domain and the Mis18α-β C-terminal coiled-coil domains. Which protein is encoded by the gene corresponding to this shared partner? | Protein Mis18-alpha | Medium | convergence | {"qa_id":"medium_convergence_03581","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and HJURP both interact with a shared protein partner. Evidence indicates that this partner is recruited to centromeres through a direct interaction be... | |
medium_convergence_03582 | Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of -2.381 and an adjusted p-value of 0.04836. Which protein is encoded by this gene? | ATP-dependent DNA helicase PIF1 | Medium | convergence | {"qa_id":"medium_convergence_03582","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold... | |
medium_convergence_03583 | CRY2 and COMMD1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We show that COMMD1 interacts with multiple Cullins, that the COMMD1-Cul2 complex cannot bind CAND1, and that, conversely, COMMD1 can actively displace CAND1 from CRLs.' Which protein is encoded by the gen... | Cullin-1 | Medium | convergence | {"qa_id":"medium_convergence_03583","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY2 and COMMD1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We show that COMMD1 interacts with multipl... | |
medium_convergence_03584 | BIRC3 and CASP7 both interact with a specific protein. Contextual evidence describes this protein as a novel entity, identified as a direct IAP binding protein with low pI, which binds MIHA and interacts with MIHB, MIHC, and the baculoviral IAP OpIAP. Which protein is encoded by the gene corresponding to this described... | Diablo IAP-binding mitochondrial protein | Medium | convergence | {"qa_id":"medium_convergence_03584","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and CASP7 both interact with a specific protein. Contextual evidence describes this protein as a novel entity, identified as a direct IAP binding prote... | |
medium_convergence_03586 | EP300 and MAX both interact with a shared transcription factor subunit. Evidence indicates that this specific subunit interacts with p300 in vivo and serves as a target for acetylation by p300. Which protein is encoded by this shared subunit? | Nuclear transcription factor Y subunit beta | Medium | convergence | {"qa_id":"medium_convergence_03586","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MAX both interact with a shared transcription factor subunit. Evidence indicates that this specific subunit interacts with p300 in vivo and serves ... | |
medium_convergence_03587 | Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 3.845 and an adjusted p-value of 0.04134. Which cellular component is this gene located in? | membrane | Medium | convergence | {"qa_id":"medium_convergence_03587","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of appr... | |
medium_convergence_03588 | DVL1 and DVL2 each interact with more than one shared protein. Evidence concerning one of these shared entities reports that it interacts with and co-localizes with Dvl-1 at the lateral membrane of polarized epithelial cells. Which disease is associated with that entity? | glioma | Medium | convergence | {"qa_id":"medium_convergence_03588","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL1 and DVL2 each interact with more than one shared protein. Evidence concerning one of these shared entities reports that it interacts with and co-localiz... | |
medium_convergence_03590 | Both Human alphaherpesvirus 3 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 1.405 and an adjusted p-value of 7.635e-05. Which cellular component is this gene located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_03590","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study... | |
medium_convergence_03592 | CSNK2B and MYC both interact with a shared protein. Experimental evidence indicates that the regulatory subunit beta of protein casein kinase 2 (CK2beta) interacts with a transcription factor, a finding confirmed by in-vitro GST pull-down and in-vivo co-immunoprecipitation assays. Which protein is encoded by the gene c... | Transcription factor AP-2-alpha | Medium | convergence | {"qa_id":"medium_convergence_03592","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MYC both interact with a shared protein. Experimental evidence indicates that the regulatory subunit beta of protein casein kinase 2 (CK2beta) int... | |
medium_convergence_03593 | EGFR and LCP2 share a common interacting partner. Evidence regarding this shared partner describes a complex involving adaptor proteins SLP-76, Nck-1, Grb2, and GADS, as well as protein phosphatases SHIP-1 and TULA-2. Which protein is encoded by this shared interacting partner? | Tyrosine-protein kinase SYK | Medium | convergence | {"qa_id":"medium_convergence_03593","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and LCP2 share a common interacting partner. Evidence regarding this shared partner describes a complex involving adaptor proteins SLP-76, Nck-1, Grb2, ... | |
medium_convergence_03594 | CTNNB1 and SET both interact with a shared protein. Evidence for one such interaction describes the use of glutathione S-transferase (GST)-beta-catenin fusion proteins to confirm binding with a protein encoded by CDK5R1, as well as the detection of beta-catenin in immunoprecipitates of that protein. Which protein is en... | Cyclin-dependent kinase 5 activator 1 | Medium | convergence | {"qa_id":"medium_convergence_03594","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and SET both interact with a shared protein. Evidence for one such interaction describes the use of glutathione S-transferase (GST)-beta-catenin fusio... | |
medium_convergence_03595 | Both sebocytes and epithelial cells of sweat glands are types of a specific cell class. Evidence regarding one shared entity states: 'An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to ... | skin gland | Medium | convergence | {"qa_id":"medium_convergence_03595","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both sebocytes and epithelial cells of sweat glands are types of a specific cell class. Evidence regarding one shared entity states: 'An epithelial cell that... | |
medium_convergence_03596 | GRB2 and CBL both interact with a specific protein. Evidence indicates that the SH3 domains of this protein bind specifically to SIP-110, a 110 kDa splice variant of SIP-145 and SIP-130 that lacks the SH2 domain. Which cellular component is this protein located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_03596","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and CBL both interact with a specific protein. Evidence indicates that the SH3 domains of this protein bind specifically to SIP-110, a 110 kDa splice va... | |
medium_convergence_03597 | ALYREF and NUP35 both interact with a common protein partner. Evidence regarding this partner states: 'Notably, adaptor protein Aly and Thoc5 can simultaneously bind to non-overlapping binding sites on a nuclear export factor complex subunit.' Which protein is encoded by the gene corresponding to this shared partner? | Nuclear RNA export factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03597","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and NUP35 both interact with a common protein partner. Evidence regarding this partner states: 'Notably, adaptor protein Aly and Thoc5 can simultaneou... | |
medium_convergence_03598 | Both Human mastadenovirus C and Zika virus have been shown to upregulate the expression of a specific gene. In a study involving lung fibroblast cell lines (GSE120891), one such shared target gene exhibited a log2 fold change of approximately 2.45 and an adjusted p-value of 0.038. What is the name of the protein encode... | Tumor necrosis factor alpha-induced protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03598","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Zika virus have been shown to upregulate the expression of a specific gene. In a study involving lung fibroblast cell lines (... | |
medium_convergence_03599 | MTOR and ATP6V1G1 share a common binding partner. Evidence indicates that oncogenic mutations in this shared entity (identified as Rag guanosine triphosphatase C) in patients with follicular lymphoma facilitate the interaction between Raptor and Rag GTPase. Which protein is encoded by this shared entity? | Ras-related GTP-binding protein C | Medium | convergence | {"qa_id":"medium_convergence_03599","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and ATP6V1G1 share a common binding partner. Evidence indicates that oncogenic mutations in this shared entity (identified as Rag guanosine triphosphata... | |
medium_convergence_03600 | CHMP4B and VPS25 both interact with a shared protein partner. Evidence regarding a complex containing this partner states: 'The complex has three lobes and contains one copy each of VPS22 and the shared partner and two copies of VPS25.' Note: The phrasing implies specific stoichiometry for the components. Which protein... | Vacuolar protein-sorting-associated protein 36 | Medium | convergence | {"qa_id":"medium_convergence_03600","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and VPS25 both interact with a shared protein partner. Evidence regarding a complex containing this partner states: 'The complex has three lobes and c... | |
medium_convergence_03601 | Vaccinia virus and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.558 and an adjusted p-value of 0.02459. Which disease is associated with this gene as a biomarker? | hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_03601","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238... | |
medium_convergence_03603 | Erythromycin and topical Minoxidil both interact with a specific drug. Evidence indicates that this drug, along with ketoconazole and cimetidine, inhibits the metabolism of newer hypnosedatives, thereby enhancing their sedative effects and suggesting a need for dose reduction. Which disease is this drug indicated for? | insomnia | Medium | convergence | {"qa_id":"medium_convergence_03603","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and topical Minoxidil both interact with a specific drug. Evidence indicates that this drug, along with ketoconazole and cimetidine, inhibits th... | |
medium_convergence_03604 | TBK1 and IKBKE both interact with a shared protein adapter. Contextual evidence indicates that TBK1 is associated with the N-terminal region of this adapter. Which protein, connected to this shared adapter via an 'encodes' relationship, is the subject of this interaction context? | TIR domain-containing adapter molecule 1 | Medium | convergence | {"qa_id":"medium_convergence_03604","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TBK1 and IKBKE both interact with a shared protein adapter. Contextual evidence indicates that TBK1 is associated with the N-terminal region of this adapter.... | |
medium_convergence_03605 | FARSB and TRIM28 share common interaction partners. One such shared partner is characterized by its interaction with the Kruppel-associated box (KRAB)-associated co-repressor KAP1, where its overexpression leads to the sustained retention of KAP1 and Heterochromatin protein 1 (HP1) on chromatin. Which protein is encode... | Protein SET | Medium | convergence | {"qa_id":"medium_convergence_03605","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FARSB and TRIM28 share common interaction partners. One such shared partner is characterized by its interaction with the Kruppel-associated box (KRAB)-associ... | |
medium_convergence_03606 | WASF2 and PFN1 share common interaction partners. One such shared partner is implicated in the rapid movement of Shigella in epithelial cells, a process dependent on its interaction with G-actin and a WASP family protein. Which gene interacts with this specific shared partner? | ARHGAP12 | Medium | convergence | {"qa_id":"medium_convergence_03606","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WASF2 and PFN1 share common interaction partners. One such shared partner is implicated in the rapid movement of Shigella in epithelial cells, a process depe... | |
medium_convergence_03607 | Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of -2.992 and an adjusted p-value of 0.03642. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_03607","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold... | |
medium_convergence_03608 | HNF4A and RBBP7 share common interaction partners. One such partner is involved in a pathway where Rifampicin strongly stimulates its interaction with hepatocyte nuclear factor 4alpha (HNF4alpha) and CYP3A4 reporter activity. This activity is further stimulated by PGC-1alpha and SRC-1 but inhibited by SHP. Which protei... | Nuclear receptor subfamily 1 group I member 2 | Medium | convergence | {"qa_id":"medium_convergence_03608","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNF4A and RBBP7 share common interaction partners. One such partner is involved in a pathway where Rifampicin strongly stimulates its interaction with hepato... | |
medium_convergence_03609 | YWHAQ and SIRT1 share multiple interacting partners. One such partner is described in evidence stating: 'Further analyses showed that both IRS-1 and IRS-2 interacted with SirT1, and the acetylation level of IRS-2 was down-regulated by insulin treatment.' Which protein is encoded by this shared interacting entity? | Insulin receptor substrate 2 | Medium | convergence | {"qa_id":"medium_convergence_03609","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and SIRT1 share multiple interacting partners. One such partner is described in evidence stating: 'Further analyses showed that both IRS-1 and IRS-2 in... | |
medium_convergence_03611 | TMEM33 and UBE2W share a common interacting partner. Evidence indicates that this shared partner co-assembles with TMEM43, ENDOD1, and TMED1 to form a complex that modulates innate immune signaling via the cGAS-STING pathway. Which protein is encoded by this shared interacting partner? | E3 ubiquitin-protein ligase RNF26 | Medium | convergence | {"qa_id":"medium_convergence_03611","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TMEM33 and UBE2W share a common interacting partner. Evidence indicates that this shared partner co-assembles with TMEM43, ENDOD1, and TMED1 to form a comple... | |
medium_convergence_03612 | MIR9-1 and MIR98 are both involved in more than one shared biological process. Evidence indicates that increased expression of miR-9-5p abrogates TGF-β1-dependent myofibroblast phenotypic transformation. Which biological process, shared by both MIR9-1 and MIR98, is connected to the entity described in the evidence thro... | myofibroblast differentiation | Medium | convergence | {"qa_id":"medium_convergence_03612","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR9-1 and MIR98 are both involved in more than one shared biological process. Evidence indicates that increased expression of miR-9-5p abrogates TGF-β1-depe... | |
medium_convergence_03613 | ABRAXAS2 and FAM175A each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'We provided evidence that a protein encoded by the gene corresponding to that shared partner interacts with BRE through a C-terminal conserved motif of the protein and a C-terminal UEV... | BRISC and BRCA1-A complex member 1 | Medium | convergence | {"qa_id":"medium_convergence_03613","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABRAXAS2 and FAM175A each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'We provided evidence ... | |
medium_convergence_03614 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of approximately -1.817 and an adjusted p-value of 0.006688. What protein is encoded by this gene? | Ras and Rab interactor 2 | Medium | convergence | {"qa_id":"medium_convergence_03614","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study... | |
medium_convergence_03615 | TNFSF12 and MAP3K14 both interact with a shared protein. Evidence regarding this shared entity states: 'Although wt and aly NIK do not differ in their in vitro binding to tumor necrosis factor receptor-associated factor 1, 2, 3, or 6 or in their in vivo association with tumor necrosis factor receptor-associated factor ... | plasma cell myeloma | Medium | convergence | {"qa_id":"medium_convergence_03615","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNFSF12 and MAP3K14 both interact with a shared protein. Evidence regarding this shared entity states: 'Although wt and aly NIK do not differ in their in vit... | |
medium_convergence_03616 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells from study GSE102481 reports a log2 fold change of approximately 3.87 and an adjusted p-value of approximately 0.0019. Which disease is associated with this gene? | pseudo-TORCH syndrome 2 | Medium | convergence | {"qa_id":"medium_convergence_03616","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells from study GSE102481 reports a lo... | |
medium_convergence_03617 | CREBBP and LMNA each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Coimmunoprecipitation assays revealed that a protein encoded by the MTDH gene interacts with cyclic AMP-responsive element binding protein-binding protein (CBP), indicating that it might act as a bridgin... | Protein LYRIC | Medium | convergence | {"qa_id":"medium_convergence_03617","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and LMNA each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Coimmunoprecipitation assays revealed th... | |
medium_convergence_03618 | Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of -1.974 and an adjusted p-value of 0.006307. Which protein is encoded by this gene? | Urokinase-type plasminogen activator | Medium | convergence | {"qa_id":"medium_convergence_03618","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibi... | |
medium_convergence_03619 | PARP1 and MRE11A share multiple interacting partners. One such shared partner has been shown to interact with MRE11 to promote the formation of the MRE11-RAD50-NBS1 (MRN) complex, thereby facilitating the activation of the homologous recombination (HR) pathway. This mechanism mediates DNA damage tolerance and is associ... | E3 ubiquitin-protein ligase RAD18 | Medium | convergence | {"qa_id":"medium_convergence_03619","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and MRE11A share multiple interacting partners. One such shared partner has been shown to interact with MRE11 to promote the formation of the MRE11-RAD... | |
medium_convergence_03620 | ATG101 and MLST8 both interact with a specific protein complex component. Experimental evidence involving size exclusion chromatography and coimmunoprecipitation of epitope-tagged subunits indicates that the major insulin-responsive form of this component is dimeric, specifically describing a structure containing two h... | Serine/threonine-protein kinase mTOR | Medium | convergence | {"qa_id":"medium_convergence_03620","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG101 and MLST8 both interact with a specific protein complex component. Experimental evidence involving size exclusion chromatography and coimmunoprecipita... | |
medium_convergence_03621 | AFF4 and CDC73 each interact with more than one shared protein. Evidence concerning one shared entity reports that P-TEFb was affinity purified from a stably transfected cell line that expresses epitope-tagged this protein, and proteins that appeared to be specifically bound were sequenced. Which cell type is enriched ... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_03621","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AFF4 and CDC73 each interact with more than one shared protein. Evidence concerning one shared entity reports that P-TEFb was affinity purified from a stably... | |
medium_convergence_03622 | ARCN1 and COG7 share a common interacting partner. Evidence regarding this shared partner includes reports of immunoprecipitation and two-hybrid system analysis within a complete COP screen, demonstrating physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which disease is as... | Baralle-Macken syndrome | Medium | convergence | {"qa_id":"medium_convergence_03622","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and COG7 share a common interacting partner. Evidence regarding this shared partner includes reports of immunoprecipitation and two-hybrid system analy... | |
medium_convergence_03623 | EFNA2 and EFNA5 both interact with a specific receptor. Evidence indicates that ephrin-A2, ephrin-A3, and ephrin-A5 bind this receptor, but they do not bind EphA4. Which disease is associated with this receptor? | dental caries | Medium | convergence | {"qa_id":"medium_convergence_03623","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EFNA2 and EFNA5 both interact with a specific receptor. Evidence indicates that ephrin-A2, ephrin-A3, and ephrin-A5 bind this receptor, but they do not bind ... | |
medium_convergence_03624 | IRAK1 and PARD6A share multiple binding partners. One such shared partner is implicated in a complex where ECT2 interacts with Par6, Par3, and PKCzeta. Which protein is encoded by this shared partner? | Protein kinase C zeta type | Medium | convergence | {"qa_id":"medium_convergence_03624","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK1 and PARD6A share multiple binding partners. One such shared partner is implicated in a complex where ECT2 interacts with Par6, Par3, and PKCzeta. Which... | |
medium_convergence_03625 | FBL and BMS1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'In this study, we identified an [entity]-interacting domain in BMS1, which is conserved in zebrafish and humans.' Which cell type is enriched for this specific shared protein? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03625","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBL and BMS1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'In this study, we identified an [entity]-interacti... | |
medium_convergence_03626 | BIRC3 and MAVS share common interacting partners. One such shared partner is characterized by evidence stating: 'Notably, the protein directly interacted with and stabilized BIRC3 through lys48-mediated polyubiquitination via its deubiquitinating enzyme activity.' Which protein is encoded by this shared interacting par... | Ubiquitin carboxyl-terminal hydrolase 35 | Medium | convergence | {"qa_id":"medium_convergence_03626","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and MAVS share common interacting partners. One such shared partner is characterized by evidence stating: 'Notably, the protein directly interacted wit... | |
medium_convergence_03627 | LRRK2 and CSNK2A1 both interact with a specific shared protein. Evidence indicates that interactions involving this protein were disrupted by the familial PARK8 mutation Y1699C, whereas pathogenic mutations at residues R1441 and R1728 strengthened these interactions. Which protein is encoded by the gene corresponding t... | Segment polarity protein dishevelled homolog DVL-3 | Medium | convergence | {"qa_id":"medium_convergence_03627","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRRK2 and CSNK2A1 both interact with a specific shared protein. Evidence indicates that interactions involving this protein were disrupted by the familial PA... | |
medium_convergence_03628 | Both 'regulation of protein localization to plasma membrane' and 'regulation of protein localization to ciliary membrane' are subtypes of a shared biological process. Evidence for one such shared process states: 'Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.' Which... | protein localization to cell periphery | Medium | convergence | {"qa_id":"medium_convergence_03628","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of protein localization to plasma membrane' and 'regulation of protein localization to ciliary membrane' are subtypes of a shared biological... | |
medium_convergence_03629 | COPB1 and ARFGAP1 both interact with a shared protein. Evidence regarding this shared entity states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' What molecular function is enabled by this shar... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03629","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and ARFGAP1 both interact with a shared protein. Evidence regarding this shared entity states: 'Herein we describe isolation of a subcomplex of coatome... | |
medium_convergence_03630 | DLG3 and SLC1A6 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We quantitatively defined the contributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 (PSD-95) and... | Glutamate receptor ionotropic, NMDA 2B | Medium | convergence | {"qa_id":"medium_convergence_03630","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and SLC1A6 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We quantitatively defined the c... | |
medium_convergence_03631 | FLNA and CD9 share common interacting partners. One such shared partner exhibits an association with CD9 that is disrupted by digitonin, a finding suggesting that CD9 associates with CD19 only through this shared partner. Which protein is encoded by this shared partner? | CD81 antigen | Medium | convergence | {"qa_id":"medium_convergence_03631","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLNA and CD9 share common interacting partners. One such shared partner exhibits an association with CD9 that is disrupted by digitonin, a finding suggesting... | |
medium_convergence_03632 | BARD1 and RAD1 both interact with a specific protein. Evidence indicates that this protein independently binds to the Rad9-Rad1-Hus1 complex (9-1-1) and the ATR activator TopBP1. Which protein is encoded by the gene corresponding to this interacting entity? | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03632","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and RAD1 both interact with a specific protein. Evidence indicates that this protein independently binds to the Rad9-Rad1-Hus1 complex (9-1-1) and the ... |
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