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medium_convergence_03745 | BMP4 and BMPR1A both interact with a common protein partner. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to a type II BMP receptor. Which protein is encoded by the gene corresponding to this shared partner? | Bone morphogenetic protein receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_03745","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP4 and BMPR1A both interact with a common protein partner. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7... | |
medium_convergence_03746 | POLR2B and POLR2E both interact with a specific protein. Evidence indicates that the interaction between this protein and RNA Polymerase II is direct and mediated by the RPB1 subunit. Which protein product is encoded by this interacting partner? | ATP-dependent DNA helicase Q5 | Medium | convergence | {"qa_id":"medium_convergence_03746","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2B and POLR2E both interact with a specific protein. Evidence indicates that the interaction between this protein and RNA Polymerase II is direct and med... | |
medium_convergence_03747 | MED16 and TAF11 both interact with a specific nuclear receptor. Experimental evidence indicates that the interaction between hTAF(II)28 and this receptor's ligand-binding domain (LBD) is ligand-reversible, whereas no such interactions were observed with retinoid X receptors (RXRs) or other receptors. Which protein is e... | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_03747","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED16 and TAF11 both interact with a specific nuclear receptor. Experimental evidence indicates that the interaction between hTAF(II)28 and this receptor's l... | |
medium_convergence_03748 | EP300 and MITF share multiple protein interaction partners. One such shared partner is implicated in a study where p300, the partner protein, and endogenous CITED2 were co-immunoprecipitated from transfected U2-OS cells, demonstrating physical interaction in vivo. Which protein product is encoded by this shared partner... | Transcription factor AP-2-alpha | Medium | convergence | {"qa_id":"medium_convergence_03748","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MITF share multiple protein interaction partners. One such shared partner is implicated in a study where p300, the partner protein, and endogenous ... | |
medium_convergence_03749 | LARP1 and SERBP1 both interact with a specific shared protein. Evidence indicates that upregulation of LARP1 leads to the stabilization of DKK4 mRNA by competitively interacting with this shared protein, thereby preventing DKK4 mRNA from undergoing B-cell translocation gene 2-dependent deadenylation and degradation, wh... | Polyadenylate-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03749","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LARP1 and SERBP1 both interact with a specific shared protein. Evidence indicates that upregulation of LARP1 leads to the stabilization of DKK4 mRNA by compe... | |
medium_convergence_03750 | LETM1 and MCU are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Two recently identified proteins, the mitochondrial Ca(2+) uniporter (MCU), which is the pore-forming subunit of a Ca(2+) channel, and mitochondrial calcium uptake 1 (MICU1), which is t... | intracellular calcium ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_03750","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LETM1 and MCU are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Two recently identifie... | |
medium_convergence_03751 | CRK and FYB1 both interact with a shared hematopoietic signaling protein. Evidence indicates that FYB binds specifically to this protein, an interaction mediated by the protein's SH2 domain. Which protein is encoded by the gene corresponding to this shared entity? | Lymphocyte cytosolic protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03751","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and FYB1 both interact with a shared hematopoietic signaling protein. Evidence indicates that FYB binds specifically to this protein, an interaction medi... | |
medium_convergence_03752 | MYC and SMARCAD1 both interact with a shared protein complex component. Experimental evidence indicates that this specific shared entity was identified as an interaction partner of native SMARCAD1 in mouse and human models using endogenous co-immunoprecipitations, specifically linking it to the RNA polymerase III gener... | General transcription factor 3C polypeptide 3 | Medium | convergence | {"qa_id":"medium_convergence_03752","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and SMARCAD1 both interact with a shared protein complex component. Experimental evidence indicates that this specific shared entity was identified as an... | |
medium_convergence_03753 | Human respirovirus 3 and Enterovirus A both downregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cell lines (study GSE147507) reports a log2 fold change of -1.430 and an adjusted p-value of 0.04933. Which cell type is this gene enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_03753","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Enterovirus A both downregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cell lines (s... | |
medium_convergence_03754 | DDX1 and MYC share a common interaction partner. Evidence regarding one such partner states: 'Here, we report that DEAD Box 1 (DDX1), a RNA helicase also implicated in DSB repair, interacts with [the partner], with co-localization of DDX1 and [the partner] observed throughout interphase.' Which protein is encoded by th... | Telomere-associated protein RIF1 | Medium | convergence | {"qa_id":"medium_convergence_03754","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX1 and MYC share a common interaction partner. Evidence regarding one such partner states: 'Here, we report that DEAD Box 1 (DDX1), a RNA helicase also imp... | |
medium_convergence_03755 | AMFR and TFRC both interact with a shared protein. Evidence indicates that this shared protein resides in a unique endosomal-like compartment and on endosomes, including recycling endosomes, where it interacts with the transferrin receptor. Which protein is encoded by this shared entity? | Autophagy-related protein 9A | Medium | convergence | {"qa_id":"medium_convergence_03755","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMFR and TFRC both interact with a shared protein. Evidence indicates that this shared protein resides in a unique endosomal-like compartment and on endosome... | |
medium_convergence_03756 | UBE2E3 and UBE2D1 both interact with a specific protein. Evidence states: 'Our studies identified four different E2 conjugating enzymes (Ube2E2, Ube2E3, Ube2G2 and Ube2L3) as specific interactors of the gene product of NCBIGene:79594.' Which protein is encoded by this interaction partner? | Mitochondrial ubiquitin ligase activator of NFKB 1 | Medium | convergence | {"qa_id":"medium_convergence_03756","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2E3 and UBE2D1 both interact with a specific protein. Evidence states: 'Our studies identified four different E2 conjugating enzymes (Ube2E2, Ube2E3, Ube2... | |
medium_convergence_03757 | HDAC6 and MAPK14 both interact with a shared protein. Evidence indicates that this shared protein, in its endogenous form, interacts with phosphorylated p38 in a ligand-dependent manner. Which protein is encoded by this shared entity? | SMAD family member 7 | Medium | convergence | {"qa_id":"medium_convergence_03757","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and MAPK14 both interact with a shared protein. Evidence indicates that this shared protein, in its endogenous form, interacts with phosphorylated p38 ... | |
medium_convergence_03758 | The orbitosphenoid cartilage element and the sphenoid cartilage element share a common anatomical classification. Evidence indicates that the orbitosphenoid endochondral element is composed primarily of cartilage tissue. Based on this evidence, which shared anatomical category is connected to the orbitosphenoid endocho... | cranial cartilage | Medium | convergence | {"qa_id":"medium_convergence_03758","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The orbitosphenoid cartilage element and the sphenoid cartilage element share a common anatomical classification. Evidence indicates that the orbitosphenoid ... | |
medium_convergence_03762 | Pegaspargase and Morphine share interactions with multiple drugs. One such shared drug, when administered concomitantly with Morphine, was reported to increase social interaction criteria in both chronic and withdrawal phases. Which disease is this shared drug indicated for? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_03762","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Morphine share interactions with multiple drugs. One such shared drug, when administered concomitantly with Morphine, was reported to increa... | |
medium_convergence_03763 | CREBBP and PRKN each interact with more than one shared protein. Evidence concerning one of these shared entities reports: 'The helix 3 and helix 12 mutations strikingly reduced the ability of this entity to interact with the coactivators steroid receptor coactivator-1, ACTR, and the CREB-binding protein.' Which protei... | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_03763","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and PRKN each interact with more than one shared protein. Evidence concerning one of these shared entities reports: 'The helix 3 and helix 12 mutation... | |
medium_convergence_03764 | NEDD4 and YWHAZ both interact with a shared gene product. Experimental evidence indicates that the PY (Pro-Tyr) motif of this shared entity binds to the WW (Trp-Trp) domains of NEDD4. Which gene interacts with this shared entity? | RB1CC1 | Medium | convergence | {"qa_id":"medium_convergence_03764","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAZ both interact with a shared gene product. Experimental evidence indicates that the PY (Pro-Tyr) motif of this shared entity binds to the WW (... | |
medium_convergence_03765 | PIK3R1 and TSG101 both interact with a specific shared protein. Evidence indicates that the phosphorylation of the tyrosine-828 residue in the C-terminal cytoplasmic domain of this shared protein mediates a direct interaction between it and the 85 kDa regulatory subunit of phosphoinositide 3-kinase (p85), leading to pr... | Prominin-1 | Medium | convergence | {"qa_id":"medium_convergence_03765","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIK3R1 and TSG101 both interact with a specific shared protein. Evidence indicates that the phosphorylation of the tyrosine-828 residue in the C-terminal cyt... | |
medium_convergence_03766 | HSPA1A and HSPA8 both interact with a shared protein partner. Evidence for the interaction with one specific partner indicates it was identified by interactome analysis and structurally determined by X-ray crystallography and NMR analyses. Which cell type is enriched in that specific shared partner? | conventional dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03766","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and HSPA8 both interact with a shared protein partner. Evidence for the interaction with one specific partner indicates it was identified by interacto... | |
medium_convergence_03767 | CREBBP and LEF1 each interact with more than one shared protein. Evidence concerning one shared entity reports that transfected and endogenous human Pygopus2 and CBP proteins co-immunoprecipitate in HEK-293 cells and both proteins co-localize in SW480 colorectal cancer cells. Which molecular function is connected to th... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03767","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and LEF1 each interact with more than one shared protein. Evidence concerning one shared entity reports that transfected and endogenous human Pygopus2... | |
medium_convergence_03768 | RHOB and NEDD4 both interact with a specific adaptor protein. Evidence indicates that this adaptor protein is a novel binding partner of NEDD4-1 and plays important roles in controlling PTEN ubiquitination by regulating NEDD4-1 activity and the association between PTEN and NEDD4-1. Which protein is encoded by the gene ... | Protein numb homolog | Medium | convergence | {"qa_id":"medium_convergence_03768","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOB and NEDD4 both interact with a specific adaptor protein. Evidence indicates that this adaptor protein is a novel binding partner of NEDD4-1 and plays im... | |
medium_convergence_03769 | PTEN and TRAF2 share a common interacting partner. Evidence for one such partner indicates that Co-immunoprecipitation confirmed the interaction between this entity and PTEN in transfected mammalian cells. Which disease is associated with this entity through genomic alterations? | syndromic disease | Medium | convergence | {"qa_id":"medium_convergence_03769","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PTEN and TRAF2 share a common interacting partner. Evidence for one such partner indicates that Co-immunoprecipitation confirmed the interaction between this... | |
medium_convergence_03770 | Cardiac Purkinje fibers and the left bundle branch are both classified as types of a specific cardiac anatomy. Evidence indicates that this shared anatomical category is part of the cardiac conduction system, receives signals from the bundle of His, and innervates the ventricular cardiac muscle. What is the broader tis... | cardiac muscle tissue | Medium | convergence | {"qa_id":"medium_convergence_03770","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiac Purkinje fibers and the left bundle branch are both classified as types of a specific cardiac anatomy. Evidence indicates that this shared anatomical... | |
medium_convergence_03771 | DDC and ARRB2 each share a binding partner. Evidence concerning one such shared entity states: 'Our data demonstrate that β-arrestin 1 and β-arrestin 2 bind constitutively to the most common dopamine D4 receptor polymorphic variants and to KLHL12 and that all three proteins can interact within a single macromolecular c... | D(4) dopamine receptor | Medium | convergence | {"qa_id":"medium_convergence_03771","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDC and ARRB2 each share a binding partner. Evidence concerning one such shared entity states: 'Our data demonstrate that β-arrestin 1 and β-arrestin 2 bind ... | |
medium_convergence_03772 | KPNB1 and NUP214 both interact with a specific nuclear transport factor. Evidence regarding this factor states: 'The import reaction is terminated by the direct binding of nuclear [Factor]GTP to importin-beta which dissociates the importin heterodimer.' Which protein product is encoded by the gene corresponding to this... | GTP-binding nuclear protein Ran | Medium | convergence | {"qa_id":"medium_convergence_03772","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNB1 and NUP214 both interact with a specific nuclear transport factor. Evidence regarding this factor states: 'The import reaction is terminated by the dir... | |
medium_convergence_03773 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 1.109 and an adjusted p-value of approximately 0.03026. Which biological process is this gene involved in? | release of cytochrome c from mitochondria | Medium | convergence | {"qa_id":"medium_convergence_03773","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_03775 | OTUB1 and TP53 share multiple interacting partners. One such shared partner is an E2 ubiquitin-conjugating enzyme that OTUB1 binds to and inhibits, specifically targeting the cognate E2 for RNF168. Which disease is associated with this specific shared partner? | fetal alcohol syndrome | Medium | convergence | {"qa_id":"medium_convergence_03775","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OTUB1 and TP53 share multiple interacting partners. One such shared partner is an E2 ubiquitin-conjugating enzyme that OTUB1 binds to and inhibits, specifica... | |
medium_convergence_03776 | NUP205 and NUP153 both interact with a shared protein. Experimental evidence for this shared protein includes specific two-hybrid interactions with several well-defined components of the nuclear pore complex (NPC) and coimmunoprecipitation with the nucleoporin NUP153 from transfected mammalian cells. Which biological p... | nucleocytoplasmic transport | Medium | convergence | {"qa_id":"medium_convergence_03776","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP205 and NUP153 both interact with a shared protein. Experimental evidence for this shared protein includes specific two-hybrid interactions with several w... | |
medium_convergence_03777 | BAK1 and BAX each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'These potential [shared protein] small-molecule inhibitors were first tested in an in vitro binding assay for their potency in inhibition of the binding of a Bak BH3 peptide to [shared protein].' Whic... | Apoptosis regulator Bcl-2 | Medium | convergence | {"qa_id":"medium_convergence_03777","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BAK1 and BAX each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'These potential [shared protein] smal... | |
medium_convergence_03778 | ERBB2 and NRG1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with a kinase and enhances its intrinsic kinase activity. Which protein is encoded by the gene corresponding to this shared entity? | Protein-tyrosine kinase 6 | Medium | convergence | {"qa_id":"medium_convergence_03778","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and NRG1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with a kinase and enhances its intrinsic k... | |
medium_convergence_03779 | BRD4 and MCM9 share common interaction partners. One such shared partner is supported by evidence stating: 'Coimmunoprecipitation experiments showed that endogenous and transfected Brd4 interacts with replication factor C (RFC), the conserved five-subunit complex essential for DNA replication.' Which disease is associa... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03779","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and MCM9 share common interaction partners. One such shared partner is supported by evidence stating: 'Coimmunoprecipitation experiments showed that end... | |
medium_convergence_03780 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fold change of -2.722 and an adjusted p-value of 0.04383. Which disease is associated with this gene as a biomarker? | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_03780","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fo... | |
medium_convergence_03781 | TRIM28 and MYC share multiple interacting partners. One such partner is described in evidence stating: 'We show that this partner interacts with TRIM28, a master regulator of gene expression, in the nucleus of NSCLC cells.' Which cell type is this shared partner enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_03781","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and MYC share multiple interacting partners. One such partner is described in evidence stating: 'We show that this partner interacts with TRIM28, a ma... | |
medium_convergence_03782 | DVL1 and DVL3 each share a binding partner. Evidence indicates that one of these shared partners interacts with Dvl-1 and co-localizes with it at the lateral membrane of polarized epithelial cells. Which disease is associated with this specific shared partner via a biomarker relationship? | pediatric osteosarcoma | Medium | convergence | {"qa_id":"medium_convergence_03782","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL1 and DVL3 each share a binding partner. Evidence indicates that one of these shared partners interacts with Dvl-1 and co-localizes with it at the lateral... | |
medium_convergence_03783 | FBL and IMP4 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In addition, we have found that hImp3, hImp4 and hMpp10 can form a stable hetero-trimeric complex in vitro, which is generated by direct interactions of both hImp3 and hImp4 with hMpp10.' Which protein is conne... | U3 small nucleolar ribonucleoprotein protein MPP10 | Medium | convergence | {"qa_id":"medium_convergence_03783","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBL and IMP4 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In addition, we have found that hImp3, hImp4 an... | |
medium_convergence_03784 | Human respirovirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene has a log2 fold change of approximately -1.167 and an adjusted p-value of 0.04685. Which protein is encoded by this ... | SAM and SH3 domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03784","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell l... | |
medium_convergence_03785 | H2AX and HIST3H3 each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity and SMURF2 serve as a stabilizer and destabilizer of H2AX, respectively, via their dynamic interactions with H2AX. Which disease is connected to that entity through an association? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_03785","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and HIST3H3 each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity and SMURF2 serve as a stabil... | |
medium_convergence_03787 | NCK1 and PDGFB both interact with a common receptor protein. Experimental evidence indicates that ligand-activated, tyrosine-autophosphorylated platelet-derived growth factor or epidermal growth factor receptors were coimmunoprecipitated with anti-Nck antibodies, and this association was mediated by the SH2 domain of N... | Platelet-derived growth factor receptor beta | Medium | convergence | {"qa_id":"medium_convergence_03787","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCK1 and PDGFB both interact with a common receptor protein. Experimental evidence indicates that ligand-activated, tyrosine-autophosphorylated platelet-deri... | |
medium_convergence_03788 | Both outer root sheath cells and hair germinal matrix cells are subtypes of a specific cell class. Evidence indicates that this shared class includes epithelial cells that are part of the outer root sheath. To which anatomical structure is this shared cell class connected via a 'part of' relationship? | hair follicle | Medium | convergence | {"qa_id":"medium_convergence_03788","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both outer root sheath cells and hair germinal matrix cells are subtypes of a specific cell class. Evidence indicates that this shared class includes epithel... | |
medium_convergence_03789 | RHOB and RAB4A both interact with a shared protein partner. Evidence for one such partner states: 'We have identified a novel 80-kDa protein that interacts specifically with the GTP-bound conformation of Rab4, and subsequent work has shown that it also interacts strongly with Rab11.' Which cell type is this specific pr... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03789","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOB and RAB4A both interact with a shared protein partner. Evidence for one such partner states: 'We have identified a novel 80-kDa protein that interacts s... | |
medium_convergence_03790 | CHM and CHML both interact with multiple shared genes. One of these shared entities is the subject of a study reporting the in vitro assembly, purification, and crystallization of the monoprenylated Rab7GDP:REP-1 complex. Which gene does this specific entity interact with? | RILP | Medium | convergence | {"qa_id":"medium_convergence_03790","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHM and CHML both interact with multiple shared genes. One of these shared entities is the subject of a study reporting the in vitro assembly, purification, ... | |
medium_convergence_03791 | MEN1 and RAD18 share common interacting partners. One such shared partner is distinguished by experimental evidence showing that it, unlike RBBP5 or ASH2L, interacts with the DNA damage repair protein RAD18. Which protein is encoded by this specific shared partner? | Histone-lysine N-methyltransferase SETD1A | Medium | convergence | {"qa_id":"medium_convergence_03791","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MEN1 and RAD18 share common interacting partners. One such shared partner is distinguished by experimental evidence showing that it, unlike RBBP5 or ASH2L, i... | |
medium_convergence_03792 | KLHL2 and WNK1 share interaction partners. One such shared partner is supported by evidence stating: 'We found that KLHL2, as well as KLHL3, was co-immunoprecipitated with all four WNK isoforms.' Which disease is associated with this specific shared entity via a biomarker relationship? | pseudohypoaldosteronism | Medium | convergence | {"qa_id":"medium_convergence_03792","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KLHL2 and WNK1 share interaction partners. One such shared partner is supported by evidence stating: 'We found that KLHL2, as well as KLHL3, was co-immunopre... | |
medium_convergence_03793 | MDM2 and MYC both interact with a shared ribosomal protein. Evidence indicates that the N-terminal region of this protein (or its paralog) binds to the central acidic domain of MDM2. Which disease is associated with this specific protein? | Diamond-Blackfan anemia 17 | Medium | convergence | {"qa_id":"medium_convergence_03793","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and MYC both interact with a shared ribosomal protein. Evidence indicates that the N-terminal region of this protein (or its paralog) binds to the centr... | |
medium_convergence_03794 | XRCC6 and HDAC1 share multiple interacting partners. One such partner is described in the following evidence: 'We now report that RFC (p140) associates with histone deacetylase activity and interacts with histone deacetylase 1 (HDAC1).' Which protein is encoded by this specific interacting partner? | Replication factor C subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_03794","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and HDAC1 share multiple interacting partners. One such partner is described in the following evidence: 'We now report that RFC (p140) associates with ... | |
medium_convergence_03795 | ANAPC1 and CCNE1 share common binding partners. One such shared partner is characterized by in vitro evidence showing that it specifically interacts with a cyclin E peptide containing phosphorylated-Thr380, but does not interact with a cognate nonphosphorylated peptide. Which protein is encoded by this shared partner? | S-phase kinase-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03795","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC1 and CCNE1 share common binding partners. One such shared partner is characterized by in vitro evidence showing that it specifically interacts with a c... | |
medium_convergence_03796 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from a study on cytotoxic T-lymphocytes (GSE106475) indicates that this gene exhibits a log2 fold change of approximately 1.157 and an adjusted p-value of 0.04... | Zinc finger protein 821 | Medium | convergence | {"qa_id":"medium_convergence_03796","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_03798 | H3F3A and RPA1 share a common interacting partner. Evidence indicates that this shared partner interacts with the H3.3/H4 histone complex in the absence of Daxx. Which protein is encoded by the gene corresponding to this shared partner? | Protein HIRA | Medium | convergence | {"qa_id":"medium_convergence_03798","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3F3A and RPA1 share a common interacting partner. Evidence indicates that this shared partner interacts with the H3.3/H4 histone complex in the absence of D... | |
medium_convergence_03799 | STUB1 and HSPA1A both interact with a shared protein. Evidence regarding one such shared partner indicates that it directly interacts with CHIP, accepts substrates from Hsc/Hsp70, and presents associated proteins to the CHIP ubiquitin conjugation machinery. Which protein is encoded by this shared partner? | BAG family molecular chaperone regulator 1 | Medium | convergence | {"qa_id":"medium_convergence_03799","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HSPA1A both interact with a shared protein. Evidence regarding one such shared partner indicates that it directly interacts with CHIP, accepts subs... | |
medium_convergence_03800 | AP2A1 and AP1G1 share a common binding partner. Evidence indicates that a site in the ankle domain of the clathrin triskelion leg binds to a common site on the appendages of tetrameric AP1 and AP2 adaptors. Which protein encodes this shared binding partner? | Clathrin heavy chain 1 | Medium | convergence | {"qa_id":"medium_convergence_03800","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2A1 and AP1G1 share a common binding partner. Evidence indicates that a site in the ankle domain of the clathrin triskelion leg binds to a common site on t... | |
medium_convergence_03801 | ADRM1 and PSMD4 both interact with a shared protein. Evidence regarding this shared protein states: 'We also report the crystal structures of the RPN13 PRU domain in complex with peptides corresponding to the RPN2 C terminus and ubiquitin.' Which protein is encoded by this shared entity? | Polyubiquitin-B | Medium | convergence | {"qa_id":"medium_convergence_03801","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMD4 both interact with a shared protein. Evidence regarding this shared protein states: 'We also report the crystal structures of the RPN13 PRU d... | |
medium_convergence_03802 | CHEK1 and CHEK2 both interact with a specific shared gene product. Experimental evidence indicates that Chk1 binds to and phosphorylates this entity, along with Cdc25A and Cdc25B, which are dual-specificity protein phosphatases that regulate cell cycle transitions by dephosphorylating cyclin-dependent kinases. Which di... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03802","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and CHEK2 both interact with a specific shared gene product. Experimental evidence indicates that Chk1 binds to and phosphorylates this entity, along w... | |
medium_convergence_03804 | CTBP1 and HDAC1 share multiple interaction partners. One such shared partner was identified in a study where a complex of nuclear binding proteins was purified by affinity chromatography and its components were identified by mass spectrometry as Jarid1b/Plu-1, G9a, LSD1, CoREST, and the entity in question. Which diseas... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_03804","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and HDAC1 share multiple interaction partners. One such shared partner was identified in a study where a complex of nuclear binding proteins was purifi... | |
medium_convergence_03805 | GATAD2B and EBF2 both interact with a shared protein partner. Experimental evidence states: 'We demonstrate direct binding of both p66 family members to MBD2 as well as this shared partner.' Which protein is encoded by this shared partner? | Methyl-CpG-binding domain protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03805","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATAD2B and EBF2 both interact with a shared protein partner. Experimental evidence states: 'We demonstrate direct binding of both p66 family members to MBD2... | |
medium_convergence_03806 | Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of 1.042 and an adjusted p-value of 0.0006556. Which molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03806","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold cha... | |
medium_convergence_03807 | GNAQ and GNB4 both interact with a specific protein. Experimental evidence indicates that Gbeta4 forms stable dimers with several Ggamma subunits, including Ggamma5, and these dimers can stimulate phospholipase beta2. Which protein, encoded by the gene interacting with both GNAQ and GNB4, corresponds to the Ggamma subu... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | Medium | convergence | {"qa_id":"medium_convergence_03807","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAQ and GNB4 both interact with a specific protein. Experimental evidence indicates that Gbeta4 forms stable dimers with several Ggamma subunits, including ... | |
medium_convergence_03808 | ILK and ACTN1 share multiple binding partners. One shared partner is described in a study stating: 'Here, we identified a novel ILK-binding protein, affixin, that consists of two tandem calponin homology domains.' Which protein is encoded by this shared binding partner? | Beta-parvin | Medium | convergence | {"qa_id":"medium_convergence_03808","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ILK and ACTN1 share multiple binding partners. One shared partner is described in a study stating: 'Here, we identified a novel ILK-binding protein, affixin,... | |
medium_convergence_03809 | Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of 2.324 and an adjusted p-value of 5.003e-07. Which protein interacts with this upregulated gene? | MAGEA10 | Medium | convergence | {"qa_id":"medium_convergence_03809","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that t... | |
medium_convergence_03810 | Both Orthohepevirus A and Zika virus downregulate a specific gene in hepatocytes. Experimental data for this gene shows a log2 fold change of approximately -1.58 and an adjusted p-value of 0.023. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03810","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus downregulate a specific gene in hepatocytes. Experimental data for this gene shows a log2 fold change of approximately -... | |
medium_convergence_03811 | CDK8 and MED19 both interact with a shared protein complex component. Evidence regarding this component states: 'By comparing MudPIT data sets obtained from six independent Mediator preparations immunoaffinity purified through their Nut2 (MED10), Med25 (MED9), Intersex, LCMR1 (MED19), AK007855 (MED28), or CRSP70 (MED26... | Mediator of RNA polymerase II transcription subunit 29 | Medium | convergence | {"qa_id":"medium_convergence_03811","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and MED19 both interact with a shared protein complex component. Evidence regarding this component states: 'By comparing MudPIT data sets obtained from ... | |
medium_convergence_03812 | PPARA and RBBP4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that the p33(ING1b) isoform associates with Sin3, SAP30, HDAC1, RbAp48, and other proteins to form large protein complexes, whereas the p24(ING1c) isoform does not. Which protein is connec... | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_03812","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPARA and RBBP4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that the p33(ING1b) isofo... | |
medium_convergence_03813 | UBQLN1 and MDM2 share a common interaction partner. Evidence regarding this shared partner states: 'We show that Rb, MDM2, and the C8 subunit of the 20S proteasome interact in vitro and in vivo and that MDM2 promotes Rb-C8 interaction.' Which protein is encoded by this shared interaction partner? | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_03813","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBQLN1 and MDM2 share a common interaction partner. Evidence regarding this shared partner states: 'We show that Rb, MDM2, and the C8 subunit of the 20S prot... | |
medium_convergence_03814 | PAX6 and WNT9A are both involved in more than one shared biological process. Evidence indicates that in the optic cup, Wnt2, Wnt2b, and WNT9A were localized in the rim of the optic cup (presumptive iris). Which biological process, connected to WNT9A through an 'is a' relationship, is best supported by this localization... | anatomical structure morphogenesis | Medium | convergence | {"qa_id":"medium_convergence_03814","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAX6 and WNT9A are both involved in more than one shared biological process. Evidence indicates that in the optic cup, Wnt2, Wnt2b, and WNT9A were localized ... | |
medium_convergence_03815 | FBXO28 and MYC share multiple interacting partners. One such shared partner is described in a study stating: 'Here we demonstrate that this protein phosphorylates MYC at three sites (T358, S373, and T400) and affects MYC functions both in vitro and in vivo.' Which disease is associated with this specific shared partner... | malignant pancreatic neoplasm | Medium | convergence | {"qa_id":"medium_convergence_03815","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXO28 and MYC share multiple interacting partners. One such shared partner is described in a study stating: 'Here we demonstrate that this protein phosphory... | |
medium_convergence_03816 | ARRB1 and ARRB2 both interact with a specific gene product. Experimental evidence indicates that in A549 lung carcinoma cells, cellular β-arrestin1/2 associates with this protein, maintaining low protein levels by recruiting the E3 ligase NEDD4L to facilitate proteasomal degradation. Which protein is encoded by the gen... | eIF-2-alpha kinase GCN2 | Medium | convergence | {"qa_id":"medium_convergence_03816","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB1 and ARRB2 both interact with a specific gene product. Experimental evidence indicates that in A549 lung carcinoma cells, cellular β-arrestin1/2 associa... | |
medium_convergence_03817 | Both Human alphaherpesvirus 1 and Influenza A virus are known to downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), the downregulation of this gene was associated with a log2 fold change of approximately -1.378 and an adjusted p-value of 0.03816. Which protein does this downregul... | KRT9 | Medium | convergence | {"qa_id":"medium_convergence_03817","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Influenza A virus are known to downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), t... | |
medium_convergence_03818 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that this gene has a log2 fold change of approximately -2.30 and an adjusted p-value of approximately 0.0338. Which protein is encoded by this gene? | Ras and Rab interactor 2 | Medium | convergence | {"qa_id":"medium_convergence_03818","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that this gene has a ... | |
medium_convergence_03819 | Both Human immunodeficiency virus 1 and Dengue virus upregulate a specific gene in macrophages. Experimental data from study GSE108897 indicates that this gene exhibits a log2 fold change of approximately 2.12 and an adjusted p-value of approximately 8.34e-05. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03819","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus upregulate a specific gene in macrophages. Experimental data from study GSE108897 indicates that this ge... | |
medium_convergence_03820 | ESR1 and ESR2 both interact with a shared protein. Evidence indicates that this shared protein is a variable component of the Mediator complex that enhances ligand-dependent ERα-mediated transcriptional activation of the CYP2C9 promoter and interacts with activated ERα via its C-terminal LXXLL motif. Which protein is e... | Mediator of RNA polymerase II transcription subunit 25 | Medium | convergence | {"qa_id":"medium_convergence_03820","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and ESR2 both interact with a shared protein. Evidence indicates that this shared protein is a variable component of the Mediator complex that enhances ... | |
medium_convergence_03821 | BARD1 and XRCC4 both interact with a common protein partner. Evidence indicates that this shared partner binds to Ku-70, the regulatory subunit of DNA-PK, and is required for the phosphorylation of p53 in the mechanism of p53-induced apoptosis. Which protein is encoded by this shared partner? | DNA repair protein Ku70 | Medium | convergence | {"qa_id":"medium_convergence_03821","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and XRCC4 both interact with a common protein partner. Evidence indicates that this shared partner binds to Ku-70, the regulatory subunit of DNA-PK, an... | |
medium_convergence_03822 | Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene in hepatocytes. Experimental data from study GSE135619 indicates that for one such shared target, the log2 fold change is -2.136 and the adjusted p-value is 0.04032. Which protein is encoded by this specific gene? | CKLF-like MARVEL transmembrane domain-containing protein 8 | Medium | convergence | {"qa_id":"medium_convergence_03822","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene in hepatocytes. Experimental data from study GSE135619 indicates that fo... | |
medium_convergence_03823 | Adalimumab and Morphine share a common interacting drug. Evidence indicates that this shared entity is an L-type dihydropyridine calcium channel blocker with relatively high blood-brain barrier penetration, and it enhances the antinociceptive properties of Morphine. Which disease is this entity indicated for? | subarachnoid hemorrhage | Medium | convergence | {"qa_id":"medium_convergence_03823","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Adalimumab and Morphine share a common interacting drug. Evidence indicates that this shared entity is an L-type dihydropyridine calcium channel blocker with... | |
medium_convergence_03824 | Erythromycin and Dexbrompheniramine both interact with a specific drug. Evidence indicates that excessive sedation can result from the concomitant administration of benzodiazepines (such as midazolam, triazolam, alprazolam, or diazepam) or nonbenzodiazepine hypnosedatives (specifically zopiclone and this drug) with CYP... | anxiety | Medium | convergence | {"qa_id":"medium_convergence_03824","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and Dexbrompheniramine both interact with a specific drug. Evidence indicates that excessive sedation can result from the concomitant administra... | |
medium_convergence_03825 | Zaire ebolavirus and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) shows a log2 fold change of approximately -2.66 and an adjusted p-value of approximately 0.00093. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03825","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (s... | |
medium_convergence_03826 | NUP205 and NUP54 both interact with a common protein partner. Evidence indicates that this partner, referred to as a nucleoporin, was associated with polypeptides of 58 and 54 kD (as reported by Finlay et al., 1991, J. Cell Biol. 114:169-183). Which disease is associated with this specific protein partner? | familial infantile bilateral striatal necrosis | Medium | convergence | {"qa_id":"medium_convergence_03826","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP205 and NUP54 both interact with a common protein partner. Evidence indicates that this partner, referred to as a nucleoporin, was associated with polypep... | |
medium_convergence_03827 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific host gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of -1.276 and an adjusted p-value of 1.047e-05. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD12 | Medium | convergence | {"qa_id":"medium_convergence_03827","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific host gene. Experimental data for this gene in a melanoma cell line (study GSE136586) re... | |
medium_convergence_03829 | Both Vaccinia virus and Measles morbillivirus are associated with the downregulation of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -2.37 and an adjusted p-value of 0.034. What is the name of the protein encoded by this gene? | Modulator of apoptosis 1 | Medium | convergence | {"qa_id":"medium_convergence_03829","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Measles morbillivirus are associated with the downregulation of a specific gene. In a study using a cervical adenocarcinoma cell line... | |
medium_convergence_03830 | Troglitazone and Morphine share multiple drug-drug interactions. One shared interacting partner is implicated in studies where its administration (along with naloxone and prazosin) decreased the antinociceptive action of morphine that had been potentiated by another agent. Which disease is this shared interacting partn... | erectile dysfunction | Medium | convergence | {"qa_id":"medium_convergence_03830","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Troglitazone and Morphine share multiple drug-drug interactions. One shared interacting partner is implicated in studies where its administration (along with... | |
medium_convergence_03831 | CRK and CD2AP both interact with a shared protein. Evidence regarding this shared protein states: 'To further investigate whether multimerization is conserved within the family of adaptor proteins, we have solved the crystal structures of the CMS N-terminal SH3 domain-forming complexes with [shared protein]- and CD2-de... | E3 ubiquitin-protein ligase CBL-B | Medium | convergence | {"qa_id":"medium_convergence_03831","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and CD2AP both interact with a shared protein. Evidence regarding this shared protein states: 'To further investigate whether multimerization is conserve... | |
medium_convergence_03832 | HDAC5 and GSK3B both interact with a shared protein. Evidence indicates that the interaction between HDAC5 and this shared protein was determined by an immunoprecipitation assay. Which protein product is encoded by this shared protein? | Transcription factor SOX-9 | Medium | convergence | {"qa_id":"medium_convergence_03832","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC5 and GSK3B both interact with a shared protein. Evidence indicates that the interaction between HDAC5 and this shared protein was determined by an immun... | |
medium_convergence_03833 | MOV10 and MYC both interact with a shared protein. Evidence indicates that this shared protein directly interacts with c-Myc and stabilizes its protein levels by preventing proteasomal degradation. Which protein is encoded by the gene corresponding to this shared entity? | Polypyrimidine tract-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03833","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MOV10 and MYC both interact with a shared protein. Evidence indicates that this shared protein directly interacts with c-Myc and stabilizes its protein level... | |
medium_convergence_03834 | AHCTF1 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint complex (MCC) as it consists of hBUBR1, hBUB3, CDC20, and MAD2 checkpoint proteins in near equal stoichiometry.' Which cellular component is connected to that entit... | kinetochore | Medium | convergence | {"qa_id":"medium_convergence_03834","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AHCTF1 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint c... | |
medium_convergence_03835 | Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately -1.082 and an adjusted p-value of 0.03552. Which protein does this gene product bind to? | PLK1 | Medium | convergence | {"qa_id":"medium_convergence_03835","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change... | |
medium_convergence_03836 | ANAPC4 and ANAPC7 each interact with multiple shared partners. One such shared partner is described as the gene CDC27, which also binds APC16 and APC7 and contains a >200-residue loop that is heavily phosphorylated during mitosis. Which disease is associated with this specific entity (CDC27) via a biomarker relationshi... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03836","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC4 and ANAPC7 each interact with multiple shared partners. One such shared partner is described as the gene CDC27, which also binds APC16 and APC7 and co... | |
medium_convergence_03837 | DMD and SGCD share a common interaction partner. Evidence regarding this shared entity states: 'Finally, we used in vitro translated proteins in an immunoprecipitation assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding region of dystrop... | Beta-2-syntrophin | Medium | convergence | {"qa_id":"medium_convergence_03837","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DMD and SGCD share a common interaction partner. Evidence regarding this shared entity states: 'Finally, we used in vitro translated proteins in an immunopre... | |
medium_convergence_03838 | STUB1 and HIF1A both interact with a specific shared protein. Evidence indicates that CHIP (also known as STUB1) physically interacts with this shared protein through its TPR and Charged domains within the nucleus. Which protein product is encoded by this shared protein? | Runt-related transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03838","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HIF1A both interact with a specific shared protein. Evidence indicates that CHIP (also known as STUB1) physically interacts with this shared protei... | |
medium_convergence_03839 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.20 and an adjusted p-value of approximately 4.59e-08. Which disease is associated with this gene as a biomarker? | Gaucher disease | Medium | convergence | {"qa_id":"medium_convergence_03839","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a ... | |
medium_convergence_03840 | MSH6 and MSH2 both interact with a specific chromatin remodeling protein. Evidence indicates that the MSH2-MSH3 mismatch repair complex is recruited to double-strand break (DSB) sites through its interaction with this protein. Which protein is encoded by the gene corresponding to this chromatin remodeling protein? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_03840","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MSH6 and MSH2 both interact with a specific chromatin remodeling protein. Evidence indicates that the MSH2-MSH3 mismatch repair complex is recruited to doubl... | |
medium_convergence_03841 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Evidence for this gene in a study (GSE102481) reports a log2 fold change of approximately 1.22 and an adjusted p-value of 0.006879. Which cell type is this gene enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03841","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Evidence for this gene in a study (GSE102481) reports a log2 fold change of app... | |
medium_convergence_03842 | FZR1 and PLK1 share a common interacting partner. Evidence indicates that binding between this shared entity and PLK1 occurs through the polo-box domain of PLK1, and that the shared entity is phosphorylated by PLK1 on threonine 37 (T37). Which disease is associated with this shared entity? | Meier-Gorlin syndrome 5 | Medium | convergence | {"qa_id":"medium_convergence_03842","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FZR1 and PLK1 share a common interacting partner. Evidence indicates that binding between this shared entity and PLK1 occurs through the polo-box domain of P... | |
medium_convergence_03843 | Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells from study GSE135833 reports a log2 fold change of approximately 1.616 and an adjusted p-value of 0.01905. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03843","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells from study GSE135833 reports a... | |
medium_convergence_03844 | ATP6AP2 and PGRMC1 share common interacting partners. One such shared partner has been shown to directly interact with ATP6AP2 in beta cells, as assessed by co-immunoprecipitation. Which protein is encoded by this shared interacting partner? | Glucagon-like peptide 1 receptor | Medium | convergence | {"qa_id":"medium_convergence_03844","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP6AP2 and PGRMC1 share common interacting partners. One such shared partner has been shown to directly interact with ATP6AP2 in beta cells, as assessed by ... | |
medium_convergence_03845 | EPS8 and KRAS both interact with a shared protein. Evidence indicates that an in vivo association between this shared protein's SH3 domain and v-Src was detected by coimmunoprecipitation. Which protein is encoded by this shared entity? | SH2 domain-containing adapter protein B | Medium | convergence | {"qa_id":"medium_convergence_03845","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS8 and KRAS both interact with a shared protein. Evidence indicates that an in vivo association between this shared protein's SH3 domain and v-Src was dete... | |
medium_convergence_03846 | CDK2 and DDB1 share a common interacting partner. Experimental evidence using coimmunoprecipitation and mass spectrometry identified this shared entity as a host protein that interacts with both cyclin-dependent kinase 2 (CDK2) and S-phase kinase-associated protein 2 (SKP2). Which protein is encoded by this shared enti... | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Medium | convergence | {"qa_id":"medium_convergence_03846","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and DDB1 share a common interacting partner. Experimental evidence using coimmunoprecipitation and mass spectrometry identified this shared entity as a ... | |
medium_convergence_03847 | ADRB2 and PTGFRN each interact with more than one shared gene product. Evidence concerning one shared entity reports that FPRP, a cell-surface Ig superfamily protein, associates specifically with this entity or with this entity and another partner, but not with integrins or other TM4SF proteins. Which protein is connec... | CD81 antigen | Medium | convergence | {"qa_id":"medium_convergence_03847","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRB2 and PTGFRN each interact with more than one shared gene product. Evidence concerning one shared entity reports that FPRP, a cell-surface Ig superfamily... | |
medium_convergence_03848 | SSBP3 and ISL2 both interact with a specific transcription factor. Evidence regarding this factor states: 'Although the interaction between most LIM homeodomain proteins is dependent on NLI, a direct interaction between the LIM domains of this factor and the homeodomains of Isl1 and Isl2 was also observed.' Which disea... | non-acquired combined pituitary hormone deficiency with spine abnormalities | Medium | convergence | {"qa_id":"medium_convergence_03848","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SSBP3 and ISL2 both interact with a specific transcription factor. Evidence regarding this factor states: 'Although the interaction between most LIM homeodom... | |
medium_convergence_03849 | C1D and NCBP2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that the protein binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking to R... | Zinc finger CCCH domain-containing protein 18 | Medium | convergence | {"qa_id":"medium_convergence_03849","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C1D and NCBP2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that the protein binds the ... | |
medium_convergence_03850 | ANAPC11 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint complex (MCC) as it consists of hBUBR1, hBUB3, CDC20, and MAD2 checkpoint proteins in near equal stoichiometry.' Which cellular component is connected to that enti... | kinetochore | Medium | convergence | {"qa_id":"medium_convergence_03850","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC11 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint ... | |
medium_convergence_03851 | Both Human betaherpesvirus 5 and Dengue virus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.58 and an adjusted p-value of 0.041. Which biological process is this gene involved in? | G protein-coupled receptor signaling pathway | Medium | convergence | {"qa_id":"medium_convergence_03851","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Dengue virus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell lin... | |
medium_convergence_03852 | GAPDH and HMGA1 both interact with a shared protein. Evidence regarding this shared protein states: 'The p38 component of OCA-S binds directly to Oct-1, exhibits potent transactivation potential, is selectively recruited to the H2B promoter in S phase, and is essential for S phase-specific H2B transcription in vivo and... | atherosclerosis | Medium | convergence | {"qa_id":"medium_convergence_03852","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAPDH and HMGA1 both interact with a shared protein. Evidence regarding this shared protein states: 'The p38 component of OCA-S binds directly to Oct-1, exhi... |
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