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medium_convergence_03633 | EP300 and SMAD2 share interaction partners. One such shared partner forms a ternary complex with EP300 and the thyroid hormone receptor (TR), as evidenced by findings that the C-terminal portion of p300 binds the N-terminal domains of both TR and this entity. Which protein is encoded by this shared interaction partner? | Myocyte-specific enhancer factor 2A | Medium | convergence | {"qa_id":"medium_convergence_03633","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SMAD2 share interaction partners. One such shared partner forms a ternary complex with EP300 and the thyroid hormone receptor (TR), as evidenced by... | |
medium_convergence_03634 | DNMT3B and EED both interact with a specific protein that serves as a core subunit of the Polycomb Repressive Complex 2 (PRC2). Evidence indicates that while EZH1/2, this shared interaction partner, and EED form the catalytic core of PRC2, a wider group of proteins associate with low stoichiometry. Which protein is enc... | Polycomb protein SUZ12 | Medium | convergence | {"qa_id":"medium_convergence_03634","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3B and EED both interact with a specific protein that serves as a core subunit of the Polycomb Repressive Complex 2 (PRC2). Evidence indicates that while... | |
medium_convergence_03635 | CTNNB1 and YWHAH share multiple interacting partners. One such partner is reported to form complexes with beta-catenin and E-cadherin during the formation of cell-cell junctions in MDCK cells. Which disease is associated with this specific partner via a biomarker relationship? | arteriosclerosis disorder | Medium | convergence | {"qa_id":"medium_convergence_03635","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and YWHAH share multiple interacting partners. One such partner is reported to form complexes with beta-catenin and E-cadherin during the formation of... | |
medium_convergence_03636 | EGFR and PSMD2 share common interacting partners. One such partner is described by evidence stating: 'A novel protein that binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor was cloned by two-hybrid screening of a HeLa cell cDNA library.' Which protein is encoded by this shar... | Tumor necrosis factor receptor superfamily member 1A | Medium | convergence | {"qa_id":"medium_convergence_03636","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and PSMD2 share common interacting partners. One such partner is described by evidence stating: 'A novel protein that binds specifically to the intracel... | |
medium_convergence_03637 | EEF1D and MYC share a common interaction partner. Evidence indicates that cooperative physical interactions among eEF1BδL, this shared entity, and HSF1 synergistically promote the expression of heat shock-responsive genes. Which protein is encoded by this shared entity? | E3 ubiquitin-protein ligase BRE1A | Medium | convergence | {"qa_id":"medium_convergence_03637","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EEF1D and MYC share a common interaction partner. Evidence indicates that cooperative physical interactions among eEF1BδL, this shared entity, and HSF1 syner... | |
medium_convergence_03638 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.215 and an adjusted p-value of 0.001776. Which protein is encoded b... | Tumor-associated calcium signal transducer 2 | Medium | convergence | {"qa_id":"medium_convergence_03638","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for t... | |
medium_convergence_03639 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. In a study of lung fibroblast cell lines (GSE120891), one such shared target gene exhibited a log2 fold change of approximately 2.53 and an adjusted p-value of approximately 0.0... | Prostaglandin E2 receptor EP2 subtype | Medium | convergence | {"qa_id":"medium_convergence_03639","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. In a study of ... | |
medium_convergence_03640 | Lenalidomide and Dexamethasone both interact with a specific third drug. Clinical evidence highlights that combining this third drug with either lenalidomide or pomalidomide results in excessive and unpredictable toxicity. Which disease is this third drug indicated for? | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_03640","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Lenalidomide and Dexamethasone both interact with a specific third drug. Clinical evidence highlights that combining this third drug with either lenalidomide... | |
medium_convergence_03641 | EIF2AK2 and IKBKG both interact with a shared protein. Evidence indicates that upon IL-1 stimulation, this protein acquires Lys63-linked polyubiquitin chains and specifically binds to NEMO, the regulatory subunit of the IkappaB kinase (IKK) complex. Which cell type is this protein enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03641","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2AK2 and IKBKG both interact with a shared protein. Evidence indicates that upon IL-1 stimulation, this protein acquires Lys63-linked polyubiquitin chains... | |
medium_convergence_03642 | MECOM and MYC both interact with a specific protein. Experimental evidence indicates that Evi1 (the protein product of MECOM) interacts with this protein in vitro and in vivo, but does not interact with other MBD family members such as Mbd1, Mbd2, Mbd4, or MeCP2. Which protein is encoded by the gene corresponding to th... | Methyl-CpG-binding domain protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03642","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECOM and MYC both interact with a specific protein. Experimental evidence indicates that Evi1 (the protein product of MECOM) interacts with this protein in ... | |
medium_convergence_03643 | CUL3 and RBX1 both interact with a specific shared protein. Evidence indicates that this shared protein is a BTB (Bric-a-brac/Tramtrack/Broad complex) domain-containing protein that functions as a substrate adaptor within CUL3-based ubiquitin ligase complexes. Which protein is encoded by the gene corresponding to this ... | Speckle-type POZ protein | Medium | convergence | {"qa_id":"medium_convergence_03643","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL3 and RBX1 both interact with a specific shared protein. Evidence indicates that this shared protein is a BTB (Bric-a-brac/Tramtrack/Broad complex) domain... | |
medium_convergence_03645 | Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately -1.236 and an adjusted p-value of 0.04032. Which cellular component is this gene located in? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_03645","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) r... | |
medium_convergence_03646 | Rhinovirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) shows a log2 fold change of approximately -1.055 and an adjusted p-value of 0.02198. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_03646","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) sho... | |
medium_convergence_03647 | OCLN and RHOB share a common interaction partner. Evidence indicates that this shared entity, identified as a tight junction-associated MAGUK protein, interacts with the transmembrane protein occludin, ZO-2, and F-actin. Which protein is connected to this shared entity through the 'encodes' relationship? | Tight junction protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03647","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OCLN and RHOB share a common interaction partner. Evidence indicates that this shared entity, identified as a tight junction-associated MAGUK protein, intera... | |
medium_convergence_03648 | ERBB2 and EREG both interact with a shared protein partner. Evidence regarding this partner states: 'We show that 8 of 10 possible homo-and heterodimeric complexes of ErbB proteins can be hierarchically induced by ligand binding.' Which protein is encoded by this shared partner? | Receptor tyrosine-protein kinase erbB-4 | Medium | convergence | {"qa_id":"medium_convergence_03648","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and EREG both interact with a shared protein partner. Evidence regarding this partner states: 'We show that 8 of 10 possible homo-and heterodimeric com... | |
medium_convergence_03649 | BIRC3 and TNFSF11 each interact with more than one shared protein. Evidence concerning one shared entity reports that endogenous coimmunoprecipitation experiments indicated that viral infection caused recruitment of cIAP1 and cIAP2 to this entity, TRAF6, and VISA. Which disease is connected to this entity through genom... | plasma cell myeloma | Medium | convergence | {"qa_id":"medium_convergence_03649","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and TNFSF11 each interact with more than one shared protein. Evidence concerning one shared entity reports that endogenous coimmunoprecipitation experi... | |
medium_convergence_03650 | YAP1 and HTR2C share a common interacting partner. Evidence regarding this shared partner indicates that Coimmunoprecipitation experiments showed that 5-HT(2C) receptors interact with PSD95 and a complex containing the protein encoded by this shared partner in vivo. Which protein is encoded by this shared interacting p... | Protein lin-7 homolog C | Medium | convergence | {"qa_id":"medium_convergence_03650","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and HTR2C share a common interacting partner. Evidence regarding this shared partner indicates that Coimmunoprecipitation experiments showed that 5-HT(2... | |
medium_convergence_03651 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.020 and an adjusted p-value of 0.002513. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03651","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_03652 | AGR2 and RNF168 share a common interaction partner. Experimental evidence indicates that this shared partner is a helicase involved in the resolution and removal of R-loops, identified through interactome assays. Which protein is encoded by this shared interaction partner? | ATP-dependent RNA helicase A | Medium | convergence | {"qa_id":"medium_convergence_03652","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGR2 and RNF168 share a common interaction partner. Experimental evidence indicates that this shared partner is a helicase involved in the resolution and rem... | |
medium_convergence_03653 | AKAP10 and IQGAP1 both interact with a specific protein. Evidence regarding this protein states: 'Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha.' Which disease is associated with this protein as a biomarker? | neonatal severe primary hyperparathyroidism | Medium | convergence | {"qa_id":"medium_convergence_03653","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP10 and IQGAP1 both interact with a specific protein. Evidence regarding this protein states: 'Based on coprecipitation assays, the R binding domain inter... | |
medium_convergence_03654 | RACK1 and NOP53 share common interaction partners. One such shared partner interacts in the cytoplasm with RACK1, which is a receptor for activated protein kinase C (PKC). Which disease is associated with this shared partner? | Mesothelioma, malignant | Medium | convergence | {"qa_id":"medium_convergence_03654","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and NOP53 share common interaction partners. One such shared partner interacts in the cytoplasm with RACK1, which is a receptor for activated protein k... | |
medium_convergence_03655 | Pegaspargase and Imatinib share a common drug interaction partner. Evidence regarding this shared entity notes that typical CYP1A2 substrates generally contain a planar ring that fits the narrow and planar active site of the enzyme; examples include propranolol, clozapine, guanabenz, flutamide, thalidomide, carbamazepi... | asthma | Medium | convergence | {"qa_id":"medium_convergence_03655","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pegaspargase and Imatinib share a common drug interaction partner. Evidence regarding this shared entity notes that typical CYP1A2 substrates generally conta... | |
medium_convergence_03656 | Both Human alphaherpesvirus 3 and Pegivirus C are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.21 and an adjusted p-value of 3.335e-05. Which disease is associated with this gene? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03656","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Pegivirus C are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE13... | |
medium_convergence_03657 | FYN and GRB2 both interact with a specific shared protein. Evidence indicates that Src homology 3 (SH3) domains from several Src family protein tyrosine kinases, including Lck, Abl, and Src, associate with this shared entity in vitro. Which disease is connected to this entity through a biomarker relationship? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03657","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and GRB2 both interact with a specific shared protein. Evidence indicates that Src homology 3 (SH3) domains from several Src family protein tyrosine kina... | |
medium_convergence_03658 | Human alphaherpesvirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Evidence for this shared target in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.014 and an adjusted p-value of 7.197e-05. Which protein is encoded by this gene? | Nuclear pore complex protein Nup85 | Medium | convergence | {"qa_id":"medium_convergence_03658","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Evidence for this shared target in a melanoma cell line (study... | |
medium_convergence_03659 | ERBB2 and ABL1 both interact with a shared protein. Experimental evidence indicates that in lysates from the human leukemia cell line K562, Bcr/Abl tyrosine kinase and three tyrosine-phosphorylated proteins (115, 120, and 155 kDa) are co-immunoprecipitated using an antibody against this shared interaction partner. Whic... | SH2/SH3 adapter protein NCK1 | Medium | convergence | {"qa_id":"medium_convergence_03659","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ABL1 both interact with a shared protein. Experimental evidence indicates that in lysates from the human leukemia cell line K562, Bcr/Abl tyrosine ... | |
medium_convergence_03660 | BMPR2 and MAP3K7 share multiple binding partners. One such partner forms a ternary complex with Siva1 and TAK1 in Jurkat T cells, as demonstrated by co-immunoprecipitation experiments. Which protein product is encoded by this shared binding partner? | E3 ubiquitin-protein ligase XIAP | Medium | convergence | {"qa_id":"medium_convergence_03660","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMPR2 and MAP3K7 share multiple binding partners. One such partner forms a ternary complex with Siva1 and TAK1 in Jurkat T cells, as demonstrated by co-immun... | |
medium_convergence_03661 | NTN1 and CDC42 both interact with a common protein target. Experimental evidence indicates that sNetrin binds exclusively to the fifth fibronectin type III repeat of this target and to each immunoglobulin repeat of UNC5. Which protein is encoded by the gene corresponding to this target? | Netrin receptor DCC | Medium | convergence | {"qa_id":"medium_convergence_03661","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NTN1 and CDC42 both interact with a common protein target. Experimental evidence indicates that sNetrin binds exclusively to the fifth fibronectin type III r... | |
medium_convergence_03662 | Both Hepacivirus C and Human mastadenovirus C are associated with the downregulation of a specific gene. In a study of peripheral blood mononuclear cells (GSE119117), this gene exhibited a log2 fold change of approximately -1.25 and an adjusted p-value of approximately 0.0056. Which protein is encoded by this gene? | Stathmin | Medium | convergence | {"qa_id":"medium_convergence_03662","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Human mastadenovirus C are associated with the downregulation of a specific gene. In a study of peripheral blood mononuclear cells (GS... | |
medium_convergence_03663 | CACNG2 and GRIP1 share interaction partners. One such shared partner is Stargazin, which is known to interact with AMPA receptor subunits and synaptic PDZ proteins like PSD-95. Which protein is encoded by the gene corresponding to this shared interaction partner? | Glutamate receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_03663","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CACNG2 and GRIP1 share interaction partners. One such shared partner is Stargazin, which is known to interact with AMPA receptor subunits and synaptic PDZ pr... | |
medium_convergence_03664 | CDC7 and CDC6 both interact with a specific shared protein. Evidence indicates that this shared protein binds strongly to ORC1 and MCM7. Which disease is associated with this shared protein? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | convergence | {"qa_id":"medium_convergence_03664","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC7 and CDC6 both interact with a specific shared protein. Evidence indicates that this shared protein binds strongly to ORC1 and MCM7. Which disease is ass... | |
medium_convergence_03665 | FAF1 and EZH2 both interact with a specific shared protein partner. Evidence regarding this partner indicates that it interacts with VCP only when VCP is complexed with Npl4, forming a heterodimer required for recruiting polyubiquitinated proteins to the UBA domain. Which protein is encoded by the gene corresponding to... | Ubiquitin recognition factor in ER-associated degradation protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03665","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF1 and EZH2 both interact with a specific shared protein partner. Evidence regarding this partner indicates that it interacts with VCP only when VCP is com... | |
medium_convergence_03666 | Factor V (F5) and LMAN1 both interact with a specific shared protein. Evidence indicates that this shared protein is localized to the ERGIC through a direct, calcium-dependent interaction with LMAN1. Which protein is encoded by the gene corresponding to this shared entity? | Multiple coagulation factor deficiency protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03666","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Factor V (F5) and LMAN1 both interact with a specific shared protein. Evidence indicates that this shared protein is localized to the ERGIC through a direct,... | |
medium_convergence_03668 | APAF1 and CASP7 both interact with a shared protein entity. Evidence indicates that this entity is a human IAP family protein capable of binding to and potently inhibiting specific cell death proteases (caspases) that function in the distal portions of the proteolytic cascades involved in apoptosis. Which protein produ... | E3 ubiquitin-protein ligase XIAP | Medium | convergence | {"qa_id":"medium_convergence_03668","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"APAF1 and CASP7 both interact with a shared protein entity. Evidence indicates that this entity is a human IAP family protein capable of binding to and poten... | |
medium_convergence_03669 | EP300 and H3C1 share multiple binding partners. One shared partner is implicated in a study stating: 'This enhancement was due to direct protein-protein interactions of both pax-6 and cdx-2 with the N-terminal C/H1 domain of p300.' Which protein is connected to this shared partner through the 'encodes' relationship? | Paired box protein Pax-6 | Medium | convergence | {"qa_id":"medium_convergence_03669","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and H3C1 share multiple binding partners. One shared partner is implicated in a study stating: 'This enhancement was due to direct protein-protein inte... | |
medium_convergence_03670 | BAZ2A and DNMT1 both interact with a common protein partner. Evidence regarding this shared partner states: 'The non-catalytic amino terminus of DNMT1 binds to [the shared partner] and a new protein, DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression.' Which protein is encoded by this shar... | Histone deacetylase 2 | Medium | convergence | {"qa_id":"medium_convergence_03670","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BAZ2A and DNMT1 both interact with a common protein partner. Evidence regarding this shared partner states: 'The non-catalytic amino terminus of DNMT1 binds ... | |
medium_convergence_03671 | SMAD1 and SMAD4 both interact with a specific protein that contains 30 zinc fingers and functions as a DNA-binding factor. This protein associates with Smads in response to BMP2 to form a complex that transcriptionally activates Xvent-2, a homeobox regulator of Xenopus mesoderm and neural development. Which protein is ... | Zinc finger protein 423 | Medium | convergence | {"qa_id":"medium_convergence_03671","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and SMAD4 both interact with a specific protein that contains 30 zinc fingers and functions as a DNA-binding factor. This protein associates with Smads... | |
medium_convergence_03672 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. In a study of melanoma cell lines (GSE136586), this gene exhibited a log2 fold change of approximately -1.13 and an adjusted p-value of 0.000465. Which biological process is this gene invol... | vacuolar transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_03672","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. In a study of melanoma cel... | |
medium_convergence_03673 | CREBBP and ASH2L each interact with more than one shared protein. Evidence concerning one of these shared entities reports that transfected and endogenous human Pygopus2 and CBP proteins co-immunoprecipitate in HEK-293 cells and both proteins co-localize in SW480 colorectal cancer cells. Which cellular component is con... | beta-catenin-TCF complex | Medium | convergence | {"qa_id":"medium_convergence_03673","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and ASH2L each interact with more than one shared protein. Evidence concerning one of these shared entities reports that transfected and endogenous hu... | |
medium_convergence_03674 | CSNK2A1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'We show that the interaction between E2 and hNAP-1 is direct and not merely mediated by the transcriptional coactivator p300, which is bound by both proteins.' Which disease is associated with this specific shared... | depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_03674","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'We show that the interaction between E2 and hNAP-1... | |
medium_convergence_03675 | EIF3A and EIF2S2 each interact with more than one shared protein. Evidence concerning one shared entity reports that activating mTOR signaling with insulin increased by as much as five-fold the amount of this shared protein bound to eIF3. Which disease is connected to that entity through biomarker? | myocardial ischemia | Medium | convergence | {"qa_id":"medium_convergence_03675","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3A and EIF2S2 each interact with more than one shared protein. Evidence concerning one shared entity reports that activating mTOR signaling with insulin i... | |
medium_convergence_03676 | DAB1 and PAFAH1B1 share common binding partners. One such shared partner is involved in a complex with Lis1, which acts as a subunit of brain platelet-activating factor acetylhydrolase (PAFAH1B). In this heterotrimeric complex, Lis1 associates with two hydrolase subunits: a 29 kDa subunit and a 30 kDa subunit. The shar... | Platelet-activating factor acetylhydrolase IB subunit alpha2 | Medium | convergence | {"qa_id":"medium_convergence_03676","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB1 and PAFAH1B1 share common binding partners. One such shared partner is involved in a complex with Lis1, which acts as a subunit of brain platelet-activa... | |
medium_convergence_03677 | ERCC1 and CENPS both interact with a common protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA branch migration activity of this shared protein. Which gene interacts with this shared protein? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_03677","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and CENPS both interact with a common protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA... | |
medium_convergence_03678 | ESR1 and HSPA8 share a common interacting partner. Evidence indicates that Tamoxifen increases the interaction between this shared partner and the Estrogen Receptor (ER) in tamoxifen-resistant cells, but not in tamoxifen-sensitive cells. Which cell type is this shared partner enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03678","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HSPA8 share a common interacting partner. Evidence indicates that Tamoxifen increases the interaction between this shared partner and the Estrogen R... | |
medium_convergence_03680 | LAMP1 and SKP1 share multiple interacting partners. One such shared partner is a protein that associates with Skp-1 and is required for the degradation of the cdk1 inhibitory tyrosine kinase wee1. Which protein is encoded by the gene corresponding to this shared partner? | Cell division cycle-associated protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03680","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMP1 and SKP1 share multiple interacting partners. One such shared partner is a protein that associates with Skp-1 and is required for the degradation of th... | |
medium_convergence_03681 | WNT7A and NRXN1 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is associated with an entity that increases the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs). Which biological process is positively regulated by this ent... | excitatory postsynaptic potential | Medium | convergence | {"qa_id":"medium_convergence_03681","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT7A and NRXN1 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is associated with an ent... | |
medium_convergence_03682 | Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.28 and an adjusted p-value of approximately 0.046. Which disease is associated with this gene? | influenza | Medium | convergence | {"qa_id":"medium_convergence_03682","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold cha... | |
medium_convergence_03683 | EGLN1 and ELOC both interact with a specific protein that functions as a tumor suppressor. Evidence indicates this protein acts as a molecular scaffold, simultaneously binding PHDs and VHL to assemble a PHD-protein-VHL complex, thereby creating an enzymatic niche that enables the efficient degradation of HIF-1α. Which ... | LIM domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03683","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGLN1 and ELOC both interact with a specific protein that functions as a tumor suppressor. Evidence indicates this protein acts as a molecular scaffold, simu... | |
medium_convergence_03684 | ESR1 and HSP90AA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Inactivation of HDAC6 leads to Hsp90 hyperacetylation, its dissociation from an essential cochaperone, [shared partner], and a loss of chaperone activity.' Which protein is encoded by the gene... | Prostaglandin E synthase 3 | Medium | convergence | {"qa_id":"medium_convergence_03684","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HSP90AA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Inactivation of HDAC6 leads t... | |
medium_convergence_03685 | CNTROB and PAN3 both interact with a shared protein entity. Evidence regarding this entity states: 'We found that human GW182 proteins recruit the PAN2-[entity] and CCR4-CAF1-NOT deadenylase complexes through direct interactions with [entity] and NOT1, respectively.' Which cell type is this entity enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03685","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNTROB and PAN3 both interact with a shared protein entity. Evidence regarding this entity states: 'We found that human GW182 proteins recruit the PAN2-[enti... | |
medium_convergence_03686 | UHRF1 and USP7 share interaction partners. One such partner is described in the following context: 'Here, we show that PCNA-associated factor 15 undergoes UHRF1-dependent dual mono-ubiquitylation on chromatin in a DNA replication-coupled manner.' Which disease is associated with this specific shared partner as a biomar... | paroxysmal atrial fibrillation | Medium | convergence | {"qa_id":"medium_convergence_03686","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UHRF1 and USP7 share interaction partners. One such partner is described in the following context: 'Here, we show that PCNA-associated factor 15 undergoes UH... | |
medium_convergence_03687 | FANCC and FAAP100 both interact with a specific shared protein. Evidence indicates that this shared protein forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which gene interacts with this shared protein? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_03687","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FAAP100 both interact with a specific shared protein. Evidence indicates that this shared protein forms a conserved DNA-remodeling complex with the... | |
medium_convergence_03688 | CDKN1C and PARP1 both interact with a specific shared protein. Experimental evidence for this shared protein indicates that no in vivo interaction was found with either p21(Waf1/Cip1) or p27(KIP1), but binding to p57(KIP2) was readily detectable in both in vivo and in vitro assays. Which protein is encoded by this shar... | Myb-related protein B | Medium | convergence | {"qa_id":"medium_convergence_03688","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1C and PARP1 both interact with a specific shared protein. Experimental evidence for this shared protein indicates that no in vivo interaction was found ... | |
medium_convergence_03691 | CRKL and ERBB3 share a common interaction partner. Experimental evidence indicates that an antibody against CrkL coprecipitates a 72-kDa protein identified as a tyrosine kinase critical for collagen-induced platelet activation. Which protein is encoded by this shared interaction partner? | Tyrosine-protein kinase SYK | Medium | convergence | {"qa_id":"medium_convergence_03691","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and ERBB3 share a common interaction partner. Experimental evidence indicates that an antibody against CrkL coprecipitates a 72-kDa protein identified a... | |
medium_convergence_03692 | AKT1 and MAPK8IP2 share common interaction partners. One such shared partner is characterized by evidence stating: 'Direct association between Akt1 and this partner was observed in primary neurons.' Which disease is associated with this specific shared partner? | cervical carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03692","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and MAPK8IP2 share common interaction partners. One such shared partner is characterized by evidence stating: 'Direct association between Akt1 and this ... | |
medium_convergence_03693 | ACSL3 and FAF2 share common interaction partners. Experimental evidence confirms that a specific protein interacts with FAF2 and ACSL3, among others, via Co-IP and confocal microscopy. Which protein is connected to the shared interaction partner identified in this evidence through the 'encodes' relationship? | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | Medium | convergence | {"qa_id":"medium_convergence_03693","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACSL3 and FAF2 share common interaction partners. Experimental evidence confirms that a specific protein interacts with FAF2 and ACSL3, among others, via Co-... | |
medium_convergence_03694 | ESR1 and HDAC1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), responsible for the interaction with the shared protein, the suppression of ER by the shared protein could be reversed, suggesting that this suppress... | Nuclear receptor subfamily 2 group C member 1 | Medium | convergence | {"qa_id":"medium_convergence_03694","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Utilizing an interaction blocker, ER-6 (amino ac... | |
medium_convergence_03695 | GDF2 and BMP7 both interact with a shared receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is associated with this receptor as a biomarker? | anemia due to chronic disorder | Medium | convergence | {"qa_id":"medium_convergence_03695","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GDF2 and BMP7 both interact with a shared receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in... | |
medium_convergence_03696 | ID1 and ID3 each interact with more than one shared protein. Evidence concerning one such shared entity reports that the dimerization of three Id proteins (ID1, Id2, and ID3) with class A E proteins, myogenic regulatory factors, and hematopoietic factors was tested in a quantitative yeast 2-hybrid assay. Which protein ... | Transcription factor 12 | Medium | convergence | {"qa_id":"medium_convergence_03696","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ID1 and ID3 each interact with more than one shared protein. Evidence concerning one such shared entity reports that the dimerization of three Id proteins (I... | |
medium_convergence_03698 | B9D2 and AURKB each interact with more than one shared gene. Evidence concerning one shared entity reports that a protein encoded by BIRC5 binds directly to both Aurora-B and INCENP in yeast two-hybrid and in vitro pull-down assays. Which disease is connected to that entity through an association? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03698","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"B9D2 and AURKB each interact with more than one shared gene. Evidence concerning one shared entity reports that a protein encoded by BIRC5 binds directly to ... | |
medium_convergence_03699 | YWHAQ and AKT1 share multiple interacting partners. One such partner is supported by evidence showing that PKC theta and 14-3-3 tau coimmunoprecipitated from Jurkat T cells, and that recombinant 14-3-3 tau interacted directly with purified PKC theta in vitro. Which disease is associated with this specific interacting p... | retinal detachment | Medium | convergence | {"qa_id":"medium_convergence_03699","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and AKT1 share multiple interacting partners. One such partner is supported by evidence showing that PKC theta and 14-3-3 tau coimmunoprecipitated from... | |
medium_convergence_03700 | Both Human immunodeficiency virus 1 and Orthohepevirus A are known to downregulate a specific shared host gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene exhibits a log2 fold change of approximately -1.17 and an adjusted p-value of 0.0042. Which cellular component is this gene l... | endoplasmic reticulum membrane | Medium | convergence | {"qa_id":"medium_convergence_03700","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Orthohepevirus A are known to downregulate a specific shared host gene. Experimental data from a study on macrophages... | |
medium_convergence_03701 | ERBB2 and ERBB4 share common binding partners. One such partner is the subject of a study reporting that its expression was detected in 70 out of 80 primary breast cancer specimens, but in none of the 19 normal breast tissue samples. Which disease is associated with this specific shared partner? | malaria | Medium | convergence | {"qa_id":"medium_convergence_03701","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ERBB4 share common binding partners. One such partner is the subject of a study reporting that its expression was detected in 70 out of 80 primary ... | |
medium_convergence_03702 | HDAC1 and HDAC2 both interact with a shared protein partner. Experimental evidence indicates that Myt1 forms a complex with this partner, and that this complex was co-immunoprecipitated from transfected mammalian cells along with HDAC1 and HDAC2. Which disease is associated with this shared protein partner via a biomar... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_03702","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC2 both interact with a shared protein partner. Experimental evidence indicates that Myt1 forms a complex with this partner, and that this compl... | |
medium_convergence_03703 | CNTROB and PAN3 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We found that human GW182 proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase complexes through direct interactions with PAN3 and NOT1, respectively.' Which protein is encoded by that entity? | Trinucleotide repeat-containing gene 6C protein | Medium | convergence | {"qa_id":"medium_convergence_03703","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNTROB and PAN3 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We found that human GW182 proteins recr... | |
medium_convergence_03704 | DDB1 and ATXN1 share multiple interacting partners. One such shared partner is implicated in evidence stating that HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, specifically this partner and Mex3b, along with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. Which protein... | E3 ubiquitin-protein ligase DZIP3 | Medium | convergence | {"qa_id":"medium_convergence_03704","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and ATXN1 share multiple interacting partners. One such shared partner is implicated in evidence stating that HOTAIR associates with E3 ubiquitin ligase... | |
medium_convergence_03706 | Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.598 and an adjusted p-value of 0.03692. Which protein is encoded by this gene? | Cytokine-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03706","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines rep... | |
medium_convergence_03707 | BET1 and STX2 share multiple interaction partners. One such partner is identified in a yeast two-hybrid assay where syntaxins 2, 3, and 4 were shown to interact with SNAP-23 and VAMP-3. Which cell type is enriched for this specific shared interaction partner? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03707","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BET1 and STX2 share multiple interaction partners. One such partner is identified in a yeast two-hybrid assay where syntaxins 2, 3, and 4 were shown to inter... | |
medium_convergence_03708 | Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -2.503 and an adjusted p-value of 0.003039. Which protein does this gene product bind to? | LIPE | Medium | convergence | {"qa_id":"medium_convergence_03708","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a l... | |
medium_convergence_03709 | Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene reports a log2 fold change of 1.332 and an adjusted p-value of 0.000293. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_03709","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene reports a log2 fold change of 1.332 and an adjusted p-value of 0.0... | |
medium_convergence_03710 | Both Vaccinia virus and Measles morbillivirus are associated with the downregulation of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of -3.475 and an adjusted p-value of 2.291e-06. Which protein is encoded by this gene? | T-complex protein 11-like protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03710","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Measles morbillivirus are associated with the downregulation of a specific gene. In a study using a cervical adenocarcinoma cell line... | |
medium_convergence_03711 | Primate erythroparvovirus 1 and Influenza A virus both upregulate a specific gene in erythroid progenitor cells. Experimental data from study GSE103460 indicates that for one such shared target, the log2 fold change is approximately 3.127 and the adjusted p-value is 0.03565. Which protein is encoded by this gene? | C-X-C motif chemokine 11 | Medium | convergence | {"qa_id":"medium_convergence_03711","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Influenza A virus both upregulate a specific gene in erythroid progenitor cells. Experimental data from study GSE103460 indic... | |
medium_convergence_03712 | HDAC1 and RBBP7 both interact with a specific protein that serves as a component of the human histone deacetylase complex. This complex is described as including Sin3, the histone deacetylases HDAC1 and HDAC2, and the histone binding proteins RbAp46 and RbAp48. Which gene encodes this specific protein? | Histone deacetylase complex subunit SAP30 | Medium | convergence | {"qa_id":"medium_convergence_03712","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and RBBP7 both interact with a specific protein that serves as a component of the human histone deacetylase complex. This complex is described as inclu... | |
medium_convergence_03713 | Measles morbillivirus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) shows a log2 fold change of -1.075 and an adjusted p-value of 6.457e-05. Which protein does this gene product interact with? | RAB5B | Medium | convergence | {"qa_id":"medium_convergence_03713","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) sho... | |
medium_convergence_03714 | CRY1 and CRY2 both interact with a specific protein. Evidence indicates that a mutant form of this protein, which fails to bind CRY1, is unable to form an SCF complex, suggesting that the interaction between CRY1 and this protein is essential for the formation of SCF(this protein). Which protein is encoded by the gene ... | F-box/LRR-repeat protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03714","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY1 and CRY2 both interact with a specific protein. Evidence indicates that a mutant form of this protein, which fails to bind CRY1, is unable to form an SC... | |
medium_convergence_03715 | YAP1 and NEDD4 share common interaction partners. One such shared partner is described in evidence stating: 'Here we show that both PPxY motifs of this protein mediate interaction with WW domains of Nedd4 and that this protein can physically interact with the WW domains of several Nedd4-family proteins.' Which protein ... | NEDD4 family-interacting protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03715","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and NEDD4 share common interaction partners. One such shared partner is described in evidence stating: 'Here we show that both PPxY motifs of this prote... | |
medium_convergence_03716 | Human orthopneumovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.091 and an adjusted p-value of 0.03326. Which disease is associated with this gene? | immunodeficiency 23 | Medium | convergence | {"qa_id":"medium_convergence_03716","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human orthopneumovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) repo... | |
medium_convergence_03717 | HDAC1 and MN1 both interact with a shared protein. Evidence indicates that a corepressor complex, including histone deacetylases (HDACs) 1 and 3, mSIN3B, and N-CoR/SMRT, interacts with this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Pre-B-cell leukemia transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03717","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and MN1 both interact with a shared protein. Evidence indicates that a corepressor complex, including histone deacetylases (HDACs) 1 and 3, mSIN3B, and... | |
medium_convergence_03719 | VAMP2 and VAMP8 both interact with a shared protein. Evidence indicates that this protein, like other syntaxin family members, binds to the SNARE proteins VAMP and SNAP-23 in vitro. Which disease is associated with this shared protein? | familial hemophagocytic lymphohistiocytosis 4 | Medium | convergence | {"qa_id":"medium_convergence_03719","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VAMP2 and VAMP8 both interact with a shared protein. Evidence indicates that this protein, like other syntaxin family members, binds to the SNARE proteins VA... | |
medium_convergence_03720 | CDK7 and AFF4 both interact with a shared protein partner. Experimental evidence indicates that P-TEFb was affinity purified from a stably transfected cell line expressing an epitope-tagged version of this shared partner, and the specifically bound proteins were subsequently sequenced. Which protein is encoded by this ... | Cyclin-dependent kinase 9 | Medium | convergence | {"qa_id":"medium_convergence_03720","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK7 and AFF4 both interact with a shared protein partner. Experimental evidence indicates that P-TEFb was affinity purified from a stably transfected cell l... | |
medium_convergence_03721 | IRAK2 and MAP3K3 both interact with a shared protein partner. Evidence regarding one such partner states: 'Interestingly, we also find that [MAP3K7] and MEKK3 form a functional complex, in which [MAP3K7] regulates autophosphorylation of MEKK3.' Which protein is encoded by the gene corresponding to this shared partner? | Mitogen-activated protein kinase kinase kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_03721","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK2 and MAP3K3 both interact with a shared protein partner. Evidence regarding one such partner states: 'Interestingly, we also find that [MAP3K7] and MEKK... | |
medium_convergence_03723 | RING1 and PCGF6 both interact with a shared protein partner. Biochemical evidence indicates that this partner, along with its homolog, associates with PCGF-RING1A/B combinations to form multiple complexes, a process that prevents the incorporation of other canonical PRC1 subunits such as CBX, PHC, and SCM. Which protei... | YY1-associated factor 2 | Medium | convergence | {"qa_id":"medium_convergence_03723","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RING1 and PCGF6 both interact with a shared protein partner. Biochemical evidence indicates that this partner, along with its homolog, associates with PCGF-R... | |
medium_convergence_03724 | Human respirovirus 3 and Influenza A virus both downregulate a specific host gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study GSE147507) shows a log2 fold change of -1.418 and an adjusted p-value of 0.04933. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_03724","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Influenza A virus both downregulate a specific host gene. Experimental data for this gene in non-small cell lung adenocarcinoma cell... | |
medium_convergence_03725 | AP2A1 and ARHGEF7 share multiple binding partners. One of these shared partners was identified as a Cool family binding partner using a yeast two-hybrid screen. Which disease is associated with this specific shared partner via a biomarker relationship? | uniparental disomy | Medium | convergence | {"qa_id":"medium_convergence_03725","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2A1 and ARHGEF7 share multiple binding partners. One of these shared partners was identified as a Cool family binding partner using a yeast two-hybrid scre... | |
medium_convergence_03728 | DDX6 and DCP1A both interact with a shared protein partner. Structural evidence indicates that the C-terminal RecA-like domain of DDX6 binds to a highly conserved FDF sequence motif located within this shared partner, which functions as a decapping activator. Which protein is encoded by the gene corresponding to this s... | Enhancer of mRNA-decapping protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03728","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX6 and DCP1A both interact with a shared protein partner. Structural evidence indicates that the C-terminal RecA-like domain of DDX6 binds to a highly cons... | |
medium_convergence_03729 | KCNE5 and SCN5A are both involved in a shared biological process. Evidence regarding one of these shared processes states: 'The human cardiac sodium channel Na(v)1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials.' Which anatomical entity is the location... | cardiac muscle tissue | Medium | convergence | {"qa_id":"medium_convergence_03729","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNE5 and SCN5A are both involved in a shared biological process. Evidence regarding one of these shared processes states: 'The human cardiac sodium channel ... | |
medium_convergence_03730 | GTF2H5 and TAF12 both interact with a shared protein partner. Experimental evidence indicates that HFD-mediated interaction enhanced the DNA binding activity of the TAF6-TAF9 pair and the pair consisting of this shared partner and TAF12, as well as a histone-like octamer complex composed of the four TAFs. Which protein... | Transcription initiation factor TFIID subunit 4B | Medium | convergence | {"qa_id":"medium_convergence_03730","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2H5 and TAF12 both interact with a shared protein partner. Experimental evidence indicates that HFD-mediated interaction enhanced the DNA binding activity... | |
medium_convergence_03731 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of approximately -7.21 and an adjusted p-value of 0.0057. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_03731","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibite... | |
medium_convergence_03732 | CRK and ERBB2 share interaction partners. One such shared partner is associated with evidence stating: 'We have identified a kinase activity, which binds to the first Crk SH3 domain and phosphorylates c-Crk on tyrosine 221 (Y221), as c-Abl.' Which protein is encoded by this shared interaction partner? | Tyrosine-protein kinase ABL2 | Medium | convergence | {"qa_id":"medium_convergence_03732","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and ERBB2 share interaction partners. One such shared partner is associated with evidence stating: 'We have identified a kinase activity, which binds to ... | |
medium_convergence_03734 | DLG4 and EGFR both interact with a shared protein. Evidence indicates that the proline-rich regions in the C-terminal half of this shared protein bind to the SH3 domain of PSD-95 and SAP102. Which disease is therapeutically associated with this shared protein? | nephritis | Medium | convergence | {"qa_id":"medium_convergence_03734","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and EGFR both interact with a shared protein. Evidence indicates that the proline-rich regions in the C-terminal half of this shared protein bind to the... | |
medium_convergence_03735 | CNOT1 and PAN3 both interact with a shared protein entity. Evidence indicates that the interaction of this shared entity with the CCR4-NOT complex is mediated by two newly discovered phylogenetically conserved motifs. Which cell type is enriched for this shared entity? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03735","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT1 and PAN3 both interact with a shared protein entity. Evidence indicates that the interaction of this shared entity with the CCR4-NOT complex is mediate... | |
medium_convergence_03736 | ATR and RAD51 both interact with a shared protein partner. Evidence indicates that in assays using purified components, phosphorylation of this shared partner by c-Abl enhances complex formation between the shared partner and RAD51, a process that cooperates with RAD51 in recombination and repair. Which protein is enco... | DNA repair protein RAD52 homolog | Medium | convergence | {"qa_id":"medium_convergence_03736","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and RAD51 both interact with a shared protein partner. Evidence indicates that in assays using purified components, phosphorylation of this shared partne... | |
medium_convergence_03737 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately 1.836 and an adjusted p-value of 0.001031. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_03737","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that ... | |
medium_convergence_03738 | PRKN and BTRC share multiple interacting partners. One such shared partner is described by the following evidence: 'Following CK2-dependent phosphorylation both UBC3B and the shared partner bind to the F-box protein beta-TrCP, the substrate recognition subunit of an SCF (Skp1, Cul1, F-box) ubiquitin ligase.' Which dise... | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03738","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and BTRC share multiple interacting partners. One such shared partner is described by the following evidence: 'Following CK2-dependent phosphorylation b... | |
medium_convergence_03739 | RPS27A and TSG101 both interact with a common protein partner. Experimental evidence indicates that this partner, along with TSG101, co-immunoprecipitated with VPS37B-FLAG, and the three proteins comigrated together in soluble complexes of the correct size for human ESCRT-I (approximately 350 kDa). Which gene interacts... | AKTIP | Medium | convergence | {"qa_id":"medium_convergence_03739","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPS27A and TSG101 both interact with a common protein partner. Experimental evidence indicates that this partner, along with TSG101, co-immunoprecipitated wi... | |
medium_convergence_03740 | KPNB1 and AAAS both interact with a specific nucleoporin. Evidence regarding this shared partner states: 'We employed a phage display system to search for proteins that interact with transportin 1 (TRN1), the import receptor for shuttling hnRNP proteins with an M9 nuclear localization sequence (NLS), and identified a s... | Nuclear pore complex protein Nup153 | Medium | convergence | {"qa_id":"medium_convergence_03740","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNB1 and AAAS both interact with a specific nucleoporin. Evidence regarding this shared partner states: 'We employed a phage display system to search for pr... | |
medium_convergence_03741 | MAPRE1 and PCM1 share a common interacting partner. Evidence indicates that this partner is an E3 ubiquitin ligase located in centriolar satellites, which interacts with and ubiquitylates AZI1 and PCM1, thereby suppressing primary cilium formation. Which biological process is this shared partner involved in? | ubiquitin-dependent protein catabolic process | Medium | convergence | {"qa_id":"medium_convergence_03741","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPRE1 and PCM1 share a common interacting partner. Evidence indicates that this partner is an E3 ubiquitin ligase located in centriolar satellites, which in... | |
medium_convergence_03742 | GDF7 and BMP2 both interact with a common receptor protein. Experimental evidence highlights the use of BMP-2 to identify epitopes for type I and type II receptor binding, specifically noting the solution of the crystal structure for a complex involving BMP-2 and the BMPR-IA receptor ectodomain. Which protein is encode... | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_03742","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GDF7 and BMP2 both interact with a common receptor protein. Experimental evidence highlights the use of BMP-2 to identify epitopes for type I and type II rec... | |
medium_convergence_03743 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -1.53 and an adjusted p-value of 0.044. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03743","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhi... | |
medium_convergence_03744 | LIG3 and BLM both interact with a specific shared protein partner. Evidence indicates that BRCA1 and BLM interact with this shared partner predominantly in S- and G2-phases, respectively. Which protein is encoded by the gene corresponding to this shared partner? | DNA repair protein RAD50 | Medium | convergence | {"qa_id":"medium_convergence_03744","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIG3 and BLM both interact with a specific shared protein partner. Evidence indicates that BRCA1 and BLM interact with this shared partner predominantly in S... |
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