qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_convergence_00001 | BHLHE22 and RBCK1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a RING finger protein functioning as an E3 ligase for oxidized iron regulatory protein suggesting oxidation signals ubiquitination. For which disea... | alpha 1-antitrypsin deficiency | Medium | convergence | {"qa_id":"medium_convergence_00001","source_qa_id":"medium_convergence_two_branch_unequal_context_0316","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BHLHE22 and RBCK1 have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00002 | CENPW and CCND1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes phosphorylated cyclin D1 recognition by a ubiquitin ligase where FBX4 and alphaB crystallin govern substrate specificity. For which disease is this protein reported as a biomarker? | malignant pleural mesothelioma | Medium | convergence | {"qa_id":"medium_convergence_00002","source_qa_id":"medium_convergence_two_branch_equal_context_0783","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CENPW and CCND1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00003 | AKAP8L, LMNA, and TOPBP1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the physical interaction between a nuclear matrix protein and a nuclear lamina protein with the binding site located at the carboxy terminus. Which disease is linked to genomic alterations i... | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_00003","source_qa_id":"medium_convergence_three_branch_context_0672","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"AKAP8L, LMNA, and TOPBP1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00004 | BATF2 and CREBBP have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a binding interaction that prevents the phosphorylation of a transcription factor during cellular differentiation. Which disease is linked to genomi... | obesity disorder | Medium | convergence | {"qa_id":"medium_convergence_00004","source_qa_id":"medium_convergence_two_branch_unequal_context_0770","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BATF2 and CREBBP have overlapping extended protein-interaction neighborhoods containing se... | |
medium_convergence_00005 | West Nile virus and Influenza A virus alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in bronchial epithelial cells with a log2 fold-change of about 1.35 and an adjusted p-value of about 0.00063. For which disease is this gene reported as a biomarker? | osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_00005","source_qa_id":"medium_convergence_two_branch_equal_context_1124","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Influenza A virus alter the expression of several genes in common. Express... | |
medium_convergence_00006 | "KLF2, USP9X, and CTNNB1 share more than one reported protein partner. Evidence concerning one of th(...TRUNCATED) | lung cancer | Medium | convergence | "{\"qa_id\":\"medium_convergence_00006\",\"source_qa_id\":\"medium_convergence_three_branch_context_(...TRUNCATED) | |
medium_convergence_00007 | "West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. Expre(...TRUNCATED) | squamous cell carcinoma | Medium | convergence | "{\"qa_id\":\"medium_convergence_00007\",\"source_qa_id\":\"medium_convergence_two_branch_equal_cont(...TRUNCATED) | |
medium_convergence_00008 | "CLEC1B and CFTR share more than one reported protein partner. Evidence concerning one of these shar(...TRUNCATED) | hepatocellular carcinoma | Medium | convergence | "{\"qa_id\":\"medium_convergence_00008\",\"source_qa_id\":\"medium_convergence_two_branch_equal_cont(...TRUNCATED) | |
medium_convergence_00009 | "HEYL and VHL have overlapping extended protein-interaction neighborhoods containing several shared (...TRUNCATED) | osteoarthritis, knee | Medium | convergence | "{\"qa_id\":\"medium_convergence_00009\",\"source_qa_id\":\"medium_convergence_two_branch_unequal_co(...TRUNCATED) | |
medium_convergence_00010 | "POU2F2 and KMT2D share more than one reported protein partner. Evidence concerning one of these sha(...TRUNCATED) | asthma | Medium | convergence | "{\"qa_id\":\"medium_convergence_00010\",\"source_qa_id\":\"medium_convergence_two_branch_equal_cont(...TRUNCATED) |
ImmunoGraphBench2027
An anonymized review release for studying the contribution of relation-level context to biomedical knowledge-graph reasoning.
Included benchmark data
| Configuration | Instances | Description |
|---|---|---|
easy |
50,000 | Direct factual QA |
medium |
20,000 | Final corrected compositional QA |
hard_context_swap |
19,985 | Relation-context swap intervention |
hard_context_quantity |
3,000 | Gold context has no quantity advantage |
hard_structural_loss |
10,000 | Partial graph-structure removal |
Hard instances are interventions on Medium instances, not an independent pool
of unrelated questions. Do not sum these rows to claim independent examples.
test denotes an evaluation collection, not an established train/test split.
Use the configuration selector above to inspect every instance in the Dataset
Viewer. data/ contains full nested JSONL records (gzip compressed). viewer/
contains the same sanitized records in Parquet with stable, readable columns.
Quick loading
from datasets import load_dataset
import json
ds = load_dataset("ImmunoGraph-Bench/ImmunoGraphBench2027", "medium", split="test")
print(ds[0]["question"])
qa = json.loads(ds[0]["record_json"])
The viewer columns are qa_id, question, answer, level, subtype,
source_medium_qa_id, and record_json. The last column is the complete QA
object, including its available graph, context and evaluation annotations.
For a non-string answer, the viewer's answer is JSON-encoded; the nested
record remains authoritative.
Record contents and leakage precautions
Medium/Hard records include question, short_answer, gold,
candidate_subgraph, and intervention-specific fields where applicable.
Easy records instead use answer, gold_triples, gold_path, and context.
Detailed fields can vary by subtype and intervention.
Do not send the entire QA object to a model. Gold answers, selected-candidate
annotations and validation metadata are evaluation-only information. Inputs
must be rendered from the fields appropriate to the experimental condition.
Stored structural-loss model_inputs are preserved verbatim; other experiments
must use their appropriate condition-specific renderer.
Minimal evaluation code
The code/ directory contains dependency-free Python demos:
python code/evaluate_predictions.py --qa data/Medium/medium_final20k_corrected.jsonl.gz --predictions predictions.jsonl
python -m unittest discover -s code -p 'test_*.py' -v
Predictions use one condition per file, with qa_id and answer (a string or
single-element list). Optional --aliases aliases.json accepts an explicitly
provided QA-ID-to-answer-variants mapping. This demo reports simple normalized
exact matching; it is not the paper's full biomedical alias adjudication.
score_frozen.py separately aggregates existing boolean judgments with an
explicit error policy. See code documentation.
Release integrity and anonymization
The published questions, answers, scientific entity IDs, graph relations,
context text and numeric metadata are retained from the frozen source records.
Historical pre-repair questions and internal repair/provenance bookkeeping are
omitted. Absolute source_file paths are reduced to basenames. No original Git
history, personal repository links, credentials or internal audit logs are
part of this release. Scientific source citations are retained.
Per-file row counts, sizes and SHA-256 digests are supplied in
data_manifest.json and viewer_manifest.json.
Scope and limitations
This initial review deposit contains the five benchmark collections above and minimal offline evaluation code. It does not yet include the full KG, the full historical construction pipeline, all model replies, embedding analyses, or the separate retrieval/random-context/Q2 experiment inputs. It is not a claim of one-command reproduction of every paper table.
Source attribution and rights
Records retain available source identifiers and evidence citations. Public access to this review deposit does not assign a new blanket licence to third-party database material or literature excerpts. Applicable source terms remain in effect. A project-wide code/data licence has not yet been assigned; no unrestricted redistribution rights are asserted here.
This resource is for research evaluation, not clinical decision-making.
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