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2,320,200 | Evaluation of B-type natriuretic peptide (BNP) levels in normal and preeclamptic women. | B-type natriuretic peptide (BNP) is synthesized in cardiac ventricles in response to volume expansion. This study evaluated BNP levels to determine trends during pregnancy, and to assess BNP as a diagnostic tool in preeclampsia.</AbstractText>We studied 163 BNP levels in 118 pregnant women, ranging from first trimester... |
2,320,201 | Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting. | Fasting is characterized by disrupted thyroid feedback, with suppressed levels of thyroid hormones and paraventricular thyrotropin releasing hormone (TRH). We found that third ventricle administration of the deiodinase inhibitor, iopanoic acid, dose-dependently reduced deiodinase type II (DII) activity selectively in t... |
2,320,202 | Spatial regulation of intracellular pH in the ventricular myocyte. | In the cardiac myocyte, an adequate intracellular proton mobility is necessary for coupling sarcolemmal proton transport to bulk cytoplasm during intracellular pH regulation. It is also important for dissipating intracellular pH nonuniformity in response to local acid/base disturbances. Because cardiac myocytes have a ... |
2,320,203 | Mitochondrial calcium signaling and energy metabolism. | A computational model of energy metabolism in the mammalian ventricular myocyte is developed to study the effect of cytosolic calcium (Ca(2+)) transients on adenosine triphosphate (ATP) production. The model couples the Jafri-Dudycha model for tricarboxylic acid cycle regulation to a modified version of the Magnus-Keiz... |
2,320,204 | Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells. | The subventricular zone (SVZ) in the neonatal mammalian forebrain simultaneously generates olfactory interneurons, astrocytes, and oligodendrocytes. The molecular cues that enable SVZ progenitors to generate three distinct cell lineages without a temporal switching mechanism are not known. Here, we demonstrate that the... |
2,320,205 | Na+-dependent HCO3- uptake into the rat choroid plexus epithelium is partially DIDS sensitive. | Several studies suggest the involvement of Na+ and HCO3- transport in the formation of cerebrospinal fluid. Two Na+-dependent HCO3- transporters were recently localized to the epithelial cells of the rat choroid plexus (NBCn1 and NCBE), and the mRNA for a third protein was also detected (NBCe2) (Praetorius J, Nejsum LN... |
2,320,206 | Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer. | We examined the effects of Herceptin, a bioengineered monoclonal antibody directed against Her-2/neu oncogene on skeletal metastasis using a xenograft model of breast cancer. Treatment of Her-2 overexpressing human breast cancer cells BT-474 with Herceptin caused a dose-dependent decrease in cell proliferation. In in v... |
2,320,207 | Sonic motor pathways in piranhas with a reassessment of phylogenetic patterns of sonic mechanisms among teleosts. | Sound production has evolved independently a number of times among teleost fishes. In most cases, sound is generated by fast contracting muscles that vibrate the swim bladder by way of their direct attachment (intrinsic muscles) or indirectly by way of other skeletal elements (extrinsic muscles). This study focuses on ... |
2,320,208 | Pro-VGF-derived peptides induce penile erection in male rats: Involvement of paraventricular nitric oxide. | The effect of four peptides derived from the C-terminal portion of rat pro-VGF(556-617) (VGF(556-576), VGF(588-617), VGF(599-617), and VGF(588-597)), on penile erection and nitric oxide production in the paraventricular nucleus of the hypothalamus was studied in male rats after injecting into this hypothalamic nucleus.... |
2,320,209 | Gracile bones, periostal appositions, hypomineralization of the cranial vault, and mental retardation in brothers: milder variant of osteocraniostenosis or new syndrome? | We report on two brothers with ossification anomalies of membranous and cranial bones, remodeling defect of long bones leading to dense, overtubulated, narrow diaphyses, metaphyseal flare, periostal hyperosotosis that increased during the first months of life, thoracic dystrophy and severe hypotonia. One boy had hyposp... |
2,320,210 | Distinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation. | The cellular proto-oncogene c-src is thought to be involved in formation, progression, and metastasis of a variety of tumor cell types, although its exact role during tumor cell genesis is not well defined. v-src, the viral oncogene counterpart of c-src, causes metastatic sarcomas, hemorrhagic disease, and hemangiosarc... |
2,320,211 | Intracellular and extracellular concentrations of Na+ modulate Mg2+ transport in rat ventricular myocytes. | Apparent free cytoplasmic concentrations of Mg2+ ([Mg2+]i) and Na+ ([Na+]i) were estimated in rat ventricular myocytes using fluorescent indicators, furaptra (mag-fura-2) for Mg2+ and sodium-binding benzofuran isophthalate for Na+, at 25 degrees C in Ca2+-free conditions. Analysis included corrections for the influence... |
2,320,212 | Estrogen and progesterone do not activate Fos in AVPV or LHRH neurons in male rats. | In rodents, females but not males, in response to escalating levels of estrogen, express a luteinizing hormone (LH) surge that is prompted by a surge in luteinizing hormone-releasing hormone (LHRH). It cannot take place if estrogen-sensitive afferents located in the anteroventral periventricular nucleus (AVPV) are eith... |
2,320,213 | First-trimester ultrasound diagnosis in a recurrent case of Walker-Warburg syndrome. | We report on two siblings with Walker-Warburg syndrome (WWS) born to a consanguineous couple. In the index case, the second-trimester scan showed ventricular dilatation and we diagnosed WWS after observing retinal detachment at 26 weeks' gestation and lissencephaly by 32 weeks' gestation in addition to hypoplasia of th... |
2,320,214 | [Astroglia formation in the neocortex of mice after temporary prenatal serotonin depletion]. | Time-course of astrocyte appearance in the neocortex of F1 (CBA/C57B1) mice after prenatal serotonin depletion was studied. To suppress serotonin synthesis, para-chlorophenylalanine was administered to females once at the early postimplantation stage of gestation. To visualize differentiating astrocytes, the immunohist... |
2,320,215 | Decrease of transthyretin synthesis at the blood-cerebrospinal fluid barrier of old sheep. | Transthyretin (TTR), synthesized by the choroid plexus (CP) and secreted into cerebrospinal fluid (CSF), is involved in thyroxine (T4) transport and chelation of beta-amyloid peptide, attenuating neurotoxicity. To characterize age-related changes in TTR synthesis, CSF and CPs were collected from young adult (1-2 years)... |
2,320,216 | Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2. | The purpose of this research was to determine the polarity and directionality of the PEPT2-mediated uptake and transepithelial transport of the neuropeptide glycyl-L-glutamine (GlyGln) in choroid plexus.</AbstractText>The transport kinetics of [3H]GlyGln was studied in neonatal rat choroid plexus epithelial cells in pr... |
2,320,217 | Inhibition of melatonin biosynthesis activates protein kinase a and induces Alzheimer-like tau hyperphosphorylation in rats. | To investigate effect of inhibiting melatonin biosynthesis on activities of protein kinase A (PKA), glycogen synthase kinase-3 (GSK-3) and tau phosphorylation at PS214 and M4 epitopes using haloperidol, a specific inhibitor of 5-hydroxyindole-O-methyltransferase.</AbstractText>Brain ventricular and intraperitoneal inje... |
2,320,218 | Colchicine treatment differently affects releasable thyrotropin-releasing hormone (TRH) pools in the hypothalamic paraventricular nucleus (PVN) and the median eminence (ME). | 1. Hypophysiotropic thyrotropin-releasing hormone (TRH) is synthesized in the hypothalamic paraventricular nucleus (PVN) and transported to the median eminence (ME) where it enters the hypophyseal portal blood. TRH in the ME is situated exclusively in nerve terminals, whereas TRH in the PVN and septum is of extrinsic (... |
2,320,219 | Unbalanced 18q/21q translocation in a patient previously reported as monosomy 21. | We describe a patient in whom full monosomy 21 was initially assumed from routine GTG-banded karyotyping. Re-examination with chromosome painting demonstrated an unbalanced translocation between the long arms of chromosomes 18 and 21. Fluorescence in situ hybridisation (FISH) and microsatellite marker analysis revealed... |
2,320,220 | [The responses of pain-related neurons in habenula to nociceptive stimuli and morphine]. | To observe the responses of pain-related neurons in habenula to the nociceptive stimuli and classic analgesic morphine for inquiring into its characteristics of pain.</AbstractText>The experiment was proceeded with adult rats under light anesthetized. Through the cannula inserted by operation or the multielectrode inje... |
2,320,221 | Ionizing radiation enhances the engraftment of transplanted in vitro-derived multipotent astrocytic stem cells. | The subependymal zone (SEZ) is a region of persistent neurogenesis in the adult mammalian brain containing a neural stem cell (NSC) pool that continuously generates migratory neuroblasts that travel in chains through the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate and functionall... |
2,320,222 | Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. | This article reports on the application of organically modified silica (ORMOSIL) nanoparticles as a nonviral vector for efficient in vivo gene delivery. Highly monodispersed, stable aqueous suspension of nanoparticles, surface-functionalized with amino groups for binding of DNA, were prepared and characterized. Stereot... |
2,320,223 | Cellular proliferation and migration following a controlled cortical impact in the mouse. | Neurogenesis following neural degeneration has been demonstrated in many models of disease and injury. The present study further examines the early proliferative and migratory response of the brain to a controlled cortical impact (CCI) model of traumatic brain injury. The CCI was centered over the forelimb sensorimotor... |
2,320,224 | [Congenital toxoplasmosis: possibilities for laboratory diagnosis]. | A case history and the steps taken in diagnosing congenital toxoplasmosis in a child whose mother experienced asymptomatic infection with the protozoon Toxoplasma gondii are presented. At pregnancy week 35, amniocentesis was performed because of fetal hydrops, ascites, hepatosplenomegaly and dilated left lateral brain ... |
2,320,225 | In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain. | Putatively active drugs are often intraventricularly administered to gain direct access to brain and circumvent the blood-brain barrier. A few studies on the normal central nervous system (CNS) have shown, however, that the distribution of materials after intraventricular injections is much more limited than presumed a... |
2,320,226 | Birth-date-dependent segregation of the mouse cerebral cortical neurons in reaggregation cultures. | Cerebral cortical neurons form a six-layered structure in which their position depends on their birth date. This developmental process requires the presence of Reelin, which is secreted by Cajal-Retzius cells in the cortical marginal zone (MZ). However, it is still unclear whether the migration from the ventricular zon... |
2,320,227 | Gene expression profiles in hypoxic preconditioning using cDNA microarray analysis: altered expression of an angiogenic factor, carcinoembryonic antigen-related cell adhesion molecule 1. | Hypoxic preconditioning has been shown to exhibit cardioprotective effects on myocardium from ischemic or reperfusion injury. The specific regulated gene involved in the hypoxia-induced cardioprotective effects is profiled in this study. Young male Wistar rats and ICR mice were exposed to sea level (as normal control) ... |
2,320,228 | CREB expression in cardiac fibroblasts and CREM expression in ventricular myocytes. | Activation of gene expression by the cAMP-dependent signaling pathway is regulated by members of the cAMP response element binding protein (CREB) family consisting of CREB, CREM, and ATF-1. It is decisively for the understanding of the heart function as to which type of heart cells expresses CREB and/or CREM. Ventricul... |
2,320,229 | Ependymal denudation and alterations of the subventricular zone occur in human fetuses with a moderate communicating hydrocephalus. | In mutant rodents, ependymal denudation occurs early in fetal life, preceding the onset of a communicating hydrocephalus, and is a key event in the etiology of this disease. The present investigation was designed to obtain evidence whether or not ependymal denudation occurs in 16- to 40-week-old human fetuses developin... |
2,320,230 | Morphogens in motion: growth control of the neural tube. | The entire vertebrate nervous system develops from a simple epithelial sheet, the neural plate which, along development, acquires the large number and wide variety of neuronal cell types required for the construction of a functional mature nervous system. These include processes of growth and pattern formation of the n... |
2,320,231 | Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors. | The Hedgehog-Gli (Hh-Gli) signaling pathway is essential for numerous events during the development of many animal cell types and organs. In particular, it controls neural cell precursor proliferation in dorsal brain structures and regulates the number of neural stem cells in distinct embryonic, perinatal, and adult ni... |
2,320,232 | Success of endoscopic third ventriculostomy in children less than 2 years of age. | Current literature reveals different opinions about the effectiveness of endoscopic third ventriculostomy in the treatment of hydrocephalus in children less than 2 years of age. Performing a retrospective evaluation of our own experience in this age group, we aimed to contribute to the growing data on the controversial... |
2,320,233 | Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients. | The present study was conducted to determine the concentration of amino acids in the cerebrospinal spinal fluid (CSF) and the activities of two tramsaminases: glutamic oxaloacetate transaminase (GOT) and glutamic pyruvate transaminase (GPT) in human Alzheimer disease (AD) and normal brain. L-glutamic acid, L-glutamine ... |
2,320,234 | Neuronal sodium channels in ventricular heart cells are localized near T-tubules openings. | Cardiac voltage-dependent sodium channels (VDSC) are known to be tetrodotoxin (TTX)-resistant. However, recent immunochemical studies suggest the presence of TTX-sensitive neuronal-type VDSC in the heart. Scanning ion conductance microscopy (SICM) coupled to electrophysiology was used to obtain more direct functional e... |
2,320,235 | Signs of normal proliferation in the telencephalon of adult male songbirds (serinus serinus), as shown by PCNA-positivity. | The immunocytochemical expression of Proliferating Cell Nuclear Antigen (PCNA) (a cycline that coadjuvates DNA polymerase delta) becomes appreciable in the cell cycle when DNA synthesis occurs; hence cells in the S phase can be revealed by means of monoclonal antibodies. Therefore, PCNA can be considered a marker of pr... |
2,320,236 | Fetal aqueductal glioneuronal hamartoma: a clinicopathological and physiopathological study of three cases. | Fetal hydrocephalus due to aqueductal stenosis is classified into two main groups: congenital (X-linked, atresia, septa and forking) and acquired (post-infectious or post-hemorrhagic, gliosis and tumors).</AbstractText>We report three fetal cases presenting with severe hydrocephalus, two of which being apparently spora... |
2,320,237 | [Transcallosal interforniceal approach for removing the medial type of thalamic gliomas]. | To report an approach for removing the medial type of thalamic gliomas.</AbstractText>Eight cases of medial type of thalamic gliomas, 4 males and 4 females, aged 22 (14 approximately 53), underwent resection of the tumor by transcallosal interforniceal approach: right frontal craniotomy, along the cerebral midline natu... |
2,320,238 | Effect of kainate-induced experimental epilepsy on NADPH-diaphorase and calcium-binding proteins in rat hippocampal neurons. | Experimental epilepsy induced in rats by infusion of kainic acid into the lateral cerebral ventricles decreased the number of NADPH-diaphorase-positive neurons in the hippocampal formation by 55-79% and increased activity of this enzyme in CA1 and CA3 pyramidal neurons. All parvalbumin-immunoreactive cells were highly ... |
2,320,239 | Severe holocarboxylase synthetase deficiency with incomplete biotin responsiveness resulting in antenatal insult in samoan neonates. | We describe 7 Polynesian babies with a unique severe form of holocarboxylase synthetase deficiency characterized by antenatal growth retardation, subependymal cysts, only partial response to biotin, and a poor outcome. |
2,320,240 | Modulation of collagen turnover in cardiovascular disease. | Collagen fibers are the most abundant components of the extracellular matrix in arteries and myocardium. Disturbances in the collagen turnover (synthesis and degradation) have been linked to inflammatory diseases including cardiovascular pathological syndromes. In the myocardium, changes in collagen turnover may result... |
2,320,241 | [Spontaneous cerebellar haematoma. Diagnosis, management and follow-up in 18 patients].<Pagination><StartPage>191</StartPage><EndPage>194</EndPage><MedlinePgn>191-4</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Describe eighteen patients with spontaneous cerebellar haematoma... | 178 patients with metabolic syndrome, 92 patients with II stage hypertonic disease and 47 patients with chronic Ischemic heart disease have been observed. Intracardiac hemodynamics has been estimated using ultrasound apparatus LOGIC-500 "General Electric". The obtained data confirmed structural-geometrical and function... |
2,320,242 | Auditory brainstem implant (ABI): new frontiers in adults and children. | Previous studies have considered only patients with neurofibromatosis type 2 (NF2) older than 12 years as candidates for an auditory brainstem implant (ABI). Our study expands the potential criteria to include both children and adult subjects with other cochlear or cochlear nerve malfunctions who either would not benef... |
2,320,243 | Physiological regulation of brain angiotensin receptor mRNA in AT1a deficient mice. | Experiments were performed to study the physiological regulation of angiotensin (Ang) AT1b receptors using Ang AT1a knockout mice (AT1aKO). Ang AT1b mRNA was analyzed in forebrain, hypothalamus, and brainstem using in situ hybridization (ISH) under baseline and water-restricted conditions. Plasma was analyzed for osmol... |
2,320,244 | Anaplastic oligodendroglioma presenting with drop metastases in the cauda equina. | Metastatic involvement of the cerebro-spinal fluid (CSF) pathway in oligodendrogliomas is not uncommon; however, symptomatic involvement of the spinal cord is very rare: less of 10 cases have been published. To our knowledge, an intracranial oligodendroglioma presenting with symptoms of drop metastases in the cauda equ... |
2,320,245 | Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brain. | To study the role of neurotrophin-responsive neurons in brain growth and developmental resistance to seizure-induced injury, we infused saporin-conjugated 192-IgG (192 IgG-saporin), a monoclonal antibody directed at the P75 neurotrophin receptors (p75(NTR)), into the ventricles of postnatal day 8 (P8) rat pups. 7-10 da... |
2,320,246 | Activation of noradrenergic transmission by alpha2-adrenoceptor antagonists counteracts deafferentation-induced neuronal death and cell proliferation in the adult mouse olfactory bulb. | The olfactory bulb is the target of neural progenitor cells that are generated in the subventricular zone of the lateral ventricle in the adult brain. This permanent neurogenesis is likely influenced by olfactory input to the bulb since previous studies have shown that cell proliferation and/or apoptotic death are stim... |
2,320,247 | Regulation of gonadotropin-releasing hormone secretion by cannabinoids. | Cannabinoids (CBs) exert untoward effects on reproduction by reducing LH secretion and suppressing gonadal function. Recent evidence suggests these effects are due primarily to hypothalamic dysfunction; however, the mechanism is obscure. Using immortalized hypothalamic GnRH neurons, we find these cells produce and secr... |
2,320,248 | Regulation of the proapoptotic factor FOXO1 (FKHR) in cardiomyocytes by growth factors and alpha1-adrenergic agonists. | Apoptotic responses in cardiomyocytes are opposed by the protein kinase Akt (protein kinase B) and thus can be suppressed by a number of growth factors and cytokines. In some cell types, Akt phosphorylates and inactivates members of the forkhead box (FOXO) family of transcription factors that are active in regulating t... |
2,320,249 | Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia. | Gray matter reduction and ventricular enlargement belong to the best replicated findings in schizophrenia. Brain morphologic changes were also found in non-schizophrenic family members (FM). The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as sch... |
2,320,250 | Open radiofrequency ablation for the management of intractable epilepsy associated with sessile hypothalamic hamartoma. | Sessile hypothalamic hamartoma (HH) often causes intractable epilepsy, which is difficult to control even by microsurgical resection and gamma knife surgery (GKS), especially when the hamartoma is intrahypothalamic, large, or irregularly shaped. We successfully applied radiofrequency ablation (RFA) to reduce its epilep... |
2,320,251 | [Role of "subtle" ultrasonographic signs during antenatal screening for trisomy 21 during the second trimester of pregnancy: meta-analysis and CPDPN protocol of the Grenoble University Hospital]. | A meta-analysis about subtle ultrasonographic signs in second trimester of pregnancy.</AbstractText>196 articles dealing with the subject--from 1985 to July 2002--were studied. Data on the 11 reported signs were collected from 92 theoretically and/or statistically valid studies. Then, the studies were selected accordin... |
2,320,252 | Caspase inhibition decreases cell death in regions of adult neurogenesis. | The generation of new neurons in adult neurogenic regions is paralleled by a high rate of cell death. To further characterize the interplay between generation and removal of new cells, we studied the role of caspase 2 (Nedd 2) and 3 (CPP 32) on the basis of the high expression of these cysteine proteases in neurogenic ... |
2,320,253 | The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation. | It is well known that inflammatory and infectious conditions of the central nervous system (CNS) differentially regulate hepatic drug metabolism through changes in cytochrome P450 (P450); however, the pathways leading to this regulation remain unknown. We provide evidence delineating a signal transduction pathway for h... |
2,320,254 | Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain. | Central nervous system disease can have devastating consequences in the severe or Hurler form of mucopolysaccharisosis I (MPS I). Intravenously administered recombinant human alpha-L-iduronidase (rhIDU) is not expected to reach and treat the brain disease due to the blood-brain barrier. To determine whether administrat... |
2,320,255 | Linear and nonlinear reconstruction for optical tomography of phantoms with nonscattering regions. | Most research in optical imaging incorrectly assumes that light transport in nonscattering regions in the head may be modeled by use of the diffusion approximation. The effect of this assumption is examined in a series of experiments on tissue-equivalent phantoms. Images from cylindrical and head-shaped phantoms with a... |
2,320,256 | Stem and progenitor cell-based therapy of the human central nervous system. | Multipotent neural stem cells, capable of giving rise to both neurons and glia, line the cerebral ventricles of all adult animals, including humans. In addition, distinct populations of nominally glial progenitor cells, which also have the capacity to generate several cell types, are dispersed throughout the subcortica... |
2,320,257 | Upregulated and prolonged differentiation potential of the ependymal cells lining the ventriculus terminalis in human fetuses. | The ventriculus terminalis (VT) is a dilated cavity within the conus medullaris of the spinal cord. Although the VT was discovered in the mid-nineteenth century, little is known about its characteristics during development in human fetuses. Ependymal cells lining the cavities within the CNS retain high differentiation ... |
2,320,258 | Comparison of electrophysiological models for human ventricular cells and tissues. | In this paper we briefly review currently published models for human ventricular cells and tissues. We discuss the Priebe-Beuckelmann (PB) model and the reduced version of this model constructed by Bernus et al. (redPB), the Ten Tusscher-Noble-Noble-Panfilov (TNNP) model and the Iyer-Mazhari-Winslow (IMW) model. We com... |
2,320,259 | Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton. | Human glial fibrillary acidic protein-delta (GFAP-delta) is a GFAP protein isoform that is encoded by an alternative splice variant of the GFAP-gene. As a result, GFAP-delta protein differs from the predominant splice form, GFAP-alpha, by its C-terminal protein sequence. In this study, we show that GFAP-delta protein i... |
2,320,260 | Reissner's fiber formation depends on developmentally regulated factors extrinsic to the subcommissural organ. | Reissner's fiber (RF) is a threadlike structure present in the third and fourth ventricles and in the central canal of the spinal cord. RF develops by the assembly of glycoproteins released into the cerebrospinal fluid (CSF) by the subcommissural organ (SCO). SCO cells differentiate early during embryonic development. ... |
2,320,261 | Transient mid-ventricular ballooning cardiomyopathy: a new entity of Takotsubo cardiomyopathy. | We present a case of a 64-year-old man with transient mid-ventricular ballooning cardiomyopathy. Left ventriculography showed morphological differences with ballooning around the whole mid-portion of the left ventricle, although precipitating factors and clinical courses were similar to Takotsubo cardiomyopathy. We sus... |
2,320,262 | Periventricular heterotopia. | Periventricular heterotopia (PH) is clinically diagnosed on the basis of the radiographic characteristics of heterotopic nodules composed of disorganized neurons along the lateral ventricles of the brain. Epilepsy is the main presenting symptom of patients with PH. Behaviorally, patients generally are of normal intelli... |
2,320,263 | Predictors of thyroid gland invasion in glottic squamous cell carcinoma. | This study examines preoperative clinical and intraoperative histopathologic characteristics that can be used to predict thyroid gland invasion in the setting of squamous cell carcinoma (SCC) of the glottis.</AbstractText>The study was retrospectively performed using 30 serially sectioned whole-organ total laryngectomy... |
2,320,264 | Effect of input resistance voltage-dependency on DC estimate of membrane capacitance in cardiac myocytes. | The measure of membrane capacitance (C(m)) in cardiac myocytes is of primary importance as an index of their size in physiological and pathological conditions, and for the understanding of their excitability. Although a plethora of very accurate methods has been developed to access C(m) value in single cells, cardiac e... |
2,320,265 | Estrogen receptor alpha and beta mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone. | Numerous factors modulate neurogenesis in the adult dentate gyrus and subventricular zone, but it is often not clear if the modulation is mediated by direct effects on the proliferating and differentiating cells or secondary to effects on other cells. Also, while some factors selectively affect neurogenesis in one of t... |
2,320,266 | Effects of centrally administered vasopressin on orofacial pain perception in rats. | Vasopressin (AVP) appears in the cerebrospinal fluid and plays an important role in nociceptive modulation in the central nervous system. The effect of increased concentration of AVP in the cerebrospinal fluid on the excitability of the hypoglossal nerve nucleus was investigated. The experiments were carried out on rat... |
2,320,267 | Brain aromatase from pejerrey fish (Odontesthes bonariensis): cDNA cloning, tissue expression, and immunohistochemical localization. | The brain-type aromatase (CYP19A2) cDNA from pejerrey Odontesthes bonariensis was characterized. Its sequence differs from the ovarian-derived aromatase (CYP19A1) previously reported for the same species. The cDNA is 2305bp in length and the deduced protein comprises 501 amino-acids. The percentage of identity was high... |
2,320,268 | Microsurgical resection of craniopharyngioma of the third ventricle via an improved transventricular approach. | Craniopharyngioma of the third ventricle is difficult to treat and its therapeutic regimens and operative approaches have been controversial. This study was undertaken to probe indications for microsurgical resection of craniopharyngioma of the third ventricle via an improved transventricular approach, its surgical pro... |
2,320,269 | Upregulation of phospholipase d expression and activation in ventricular pressure-overload hypertrophy.<Pagination><StartPage>244</StartPage><EndPage>254</EndPage><MedlinePgn>244-54</MedlinePgn></Pagination><Abstract><AbstractText>Evidence for a role of phospholipase D (PLD) in cellular proliferation and differentiatio... | Evidence for a role of phospholipase D (PLD) in cellular proliferation and differentiation is accumulating. We studied PLD activity and expression in normal and hypertrophic rat and human hearts. In rat heart, abdominal aortic banding (constriction to 50% of original lumen) caused hypertrophy in the left ventricle (as ... |
2,320,270 | Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice. | The strategic localization of peptide transporter 2 (PEPT2), a proton-coupled oligopeptide transporter, to the apical membrane of epithelial cells in the kidney and choroid plexus suggests that it plays an important role in the disposition of peptides/mimetics in the body. Therefore, the in vivo significance of PEPT2 w... |
2,320,271 | Microanatomy of the intrachoroidal vasculature of the lateral ventricle. | Intraventricular surgery requires a detailed knowledge of the microanatomy of the choroid plexus vasculature.</AbstractText>Twenty choroid plexuses were microdissected, and two additional plexuses were prepared for microscopic examination.</AbstractText>The choroid plexus was perfused primarily by the anterior choroida... |
2,320,272 | Neurotoxic action of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine. | To determine whether behavioral sensitization produced by prolonged D-amphetamine administration affects susceptibility of nigrostriatal dopaminergic neurons to the neurotoxic actions of 6-hydroxydopamine (6-OHDA), rats were treated daily from the 23 rd day after birth for 11 consecutive days with D-amphetamine (1.0 mg... |
2,320,273 | Late-onset neurologic disease in glutaryl-CoA dehydrogenase deficiency. | Neurologic disease in glutaryl-CoA dehydrogenase (GCDH) deficiency usually presents with acute encephalopathic crises before 2 years of age. The authors report two previously asymptomatic patients with macrocephaly presenting with progressive neurologic deterioration and a severe leukoencephalopathy during adolescence ... |
2,320,274 | Imaging of fetal cerebral ventriculomegaly: a guide to management and outcome. | Ultrasound imaging is the screening modality of choice for initial evaluation of the fetal central nervous system. However, there are times when fast magnetic resonance imaging (MRI) provides information additional to that available from ultrasound. This review will: (1) discuss the ultrasound evaluation of ventriculom... |
2,320,275 | New technical approaches in stereotaxic catheterization of cerebral ventriculi: implications for the L-arginine/NO synthase/nitric oxide cascade. | In order to study the actions of certain substances at cerebral level, a stereotactic device for ensuring a precise catheterization of points in certain cerebral areas was used. For the operation technique was used a stereotaxic atlas specifically designed for rat brain (G. Paxinos, C. Watson, 1998), which offers all t... |
2,320,276 | [Correlation between cranial vault size and brain size over time: preliminary MRI evaluation]. | To correlate changes of cranial vault measurements of an adult population during the aging process with brain size using the maximum width of the third ventricle in the axial AC-PC plane.</AbstractText>Prospective study of 126 adult subjects (range: 20 to 80 years) with normal brain MRI and without history of neuropsyc... |
2,320,277 | Urocortin 1 expression in five pairs of rat lines selectively bred for differences in alcohol drinking. | There is accumulating evidence that the neuropeptide urocortin 1 (Ucn1) is involved in alcohol consumption. Thus far, however, most studies have been performed in mice.</AbstractText>The purpose of the present study was to characterize Ucn1 expression in rats selectively bred for either high or low alcohol intake.</Abs... |
2,320,278 | Comparative study on apoptosis in the testes of normal and alcoholic rats. | To investigate the tissue injury associated with long-term alcohol consumption in male gonads. To this end, apoptotic testicle tissues of alcoholic rats were compared with the testicle tissues of the control rats.</AbstractText>This study was conducted in the Department of Anatomy and Division of Pathology, Faculty of ... |
2,320,279 | Distinct forebrain and caudal brainstem contributions to the neuropeptide Y mediation of ghrelin hyperphagia. | Neuropeptide Y (NPY) has been implicated in the downstream mediation of ghrelin hyperphagia, with the site of action for both peptides considered to be intrinsic to the hypothalamus. Here, however, we observed robust hyperphagia with caudal brainstem (CBS) (fourth intracerebroventricular) ghrelin delivery and, moreover... |
2,320,280 | Mediterranean Diplodus annularis (Teleostei: Sparidae) and its brain parasite: unforeseen outcome. | Patterns of parasite load and aggregation of the bird trematode Cardiocephaloides longicollis in its main intermediate host in the Mediterranean, the annular sea bream, Diplodus annularis, were studied in a large sample collected off Valencia (Spain) and are discussed within the context of the parasite induced host mor... |
2,320,281 | Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. | This study examined the tissue distribution, cellular localization, and developmental expression of the PEPT2 protein in rat brain. Immunoblot and immunocytochemistry analyses were performed with specific rat PEPT1 and PEPT2 antisera developed in our laboratory. Rats were examined from fetus (gestation for 17 days) to ... |
2,320,282 | Meningioma growth and interferon beta-1b treated multiple sclerosis: coincidence or relationship? | Although the coincidence of multiple sclerosis (MS) and central nervous system (CNS) tumors has been reported in over 30 cases in English literature, meningioma growth was associated with interferon-beta (INF-b) treated MS only in two of them. We report the case of a 19-year-old woman with clinically possible, laborato... |
2,320,283 | Mild cerebral ventriculomegaly in fetuses: characteristics and outcome. | A fetal ultrasonographic (US) finding of mild ventriculomegaly (MVM) is not uncommon, but its prognostic significance is not clearly defined.</AbstractText>To evaluate the clinical and US characteristics and outcome of fetuses with mild dilatation of the cerebral lateral ventricles.</AbstractText>We reviewed the medica... |
2,320,284 | The total length of myocytes and capillaries, and total number of myocyte nuclei in the rat heart are time-dependently increased by growth hormone. | Growth hormone (GH) can increase size and dimensions of rat hearts. The aim was to study how GH administration influences the growth of cardiac myocytes and capillaries in relation to time. Three-month-old female rats were divided into 10 groups (n=3), and injected with either GH (5mg/kg/day) or vehicle for 5, 10, 20, ... |
2,320,285 | Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. | Chronic neuroinflammation plays a prominent role in the progression of Alzheimer's disease. Reactive microglia and astrocytes are observed within the hippocampus during the early stages of the disease. Epidemiological findings suggest that anti-inflammatory therapies may slow the onset of Alzheimer's disease. Chemokine... |
2,320,286 | The Noble cardiac ventricular electrophysiology models in CellML. | We present a review of the cardiac ventricular cell electrophysiology models developed by Prof. Denis Noble and colleagues as an example of how models may be published using a web-based CellML publication framework. The models reviewed have been marked-up in CellML and then used to compute all results presented here. T... |
2,320,287 | The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives. | Schizophrenia is associated with subtle eye movement and brain structural abnormalities, but the extent to which these abnormalities occur in the same individuals is unclear. The relationship between quantitative measures of eye movement task performance (smooth pursuit and antisaccade) and MRI volumetric measurements ... |
2,320,288 | Sequence, circulating levels, and expression of C-type natriuretic peptide in a euryhaline elasmobranch, Carcharhinus leucas. | The present study has examined expression and circulating levels of C-type natriuretic peptide (CNP) in the euryhaline bull shark, Carcharhinus leucas. Complementary DNA and deduced amino acid sequence for CNP in C. leucas were determined by RACE methods. Homology of CNP amino acid sequence in C. leucas was high both f... |
2,320,289 | Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase. | Patients with severe deficiency of methylenetetrahydrofolate reductase (MTHFR) suffer from a wide variety of neurological problems, which can begin in the neonatal period. MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethyla... |
2,320,290 | Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats. | Traumatic brain injury causes long-term neurological motor and cognitive deficits, often with limited recovery. The inability of CNS axons to regenerate following traumatic brain injury may be due, in part, to inhibitory molecules associated with myelin. One of these myelin-associated proteins, Nogo-A, inhibits neurite... |
2,320,291 | Natural expression of immature Ucn antisense RNA in the rat brain. Evidence favoring bidirectional transcription of the Ucn gene locus. | Recently, it has been shown the endogenous expression of an antisense urocortin (Ucn) transcript in the rat brain and other tissues. In the present work, by means of two complementary techniques, specific-strand RT-PCR and in situ hybridization, we showed the natural expression of a second novel antisense Ucn RNA of hi... |
2,320,292 | [The effect of ribozyme specially cleaving per1 mRNA on c-fos mRNA and its expression in hippocampus of morphine addicted mice]. | To study the change of c-fos mRNA and protein in hippocampus of morphine addicted mice after injected with ribozyme specially cleaving per1 mRNA.</AbstractText>The recombined plasmid pcDNA 3.1-per1RZ DNA was injected into the ventricles of morphine addicted mice to transcript the corresponding ribozyme which cleaves pe... |
2,320,293 | Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. | Overexpression of 5T4 oncofoetal antigen, an early marker of ES cell differentiation, in vitro increases cellular motility and decreases adhesion, properties relevant to development and cancer. Embryonic expression of m5T4 antigen is first detected on trophectoderm at implantation and is restricted to extra-embryonic t... |
2,320,294 | Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats. | Alcohol is a caloric compound that can contribute to energy intake. Therefore, peptides that regulate energy balance likely modify the motivation to consume alcohol. Melanin-concentrating hormone (MCH) regulates energy homeostasis and has been implicated in other behaviors that impact alcohol consumption (i.e., anxiety... |
2,320,295 | Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. | Neurogenesis persists in the olfactory bulb (OB) of the adult mammalian brain. New interneurons are continually added to the OB from the subventricular zone (SVZ) via the rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. ... |
2,320,296 | Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. | Ovulation is caused by a sequence of neuroendocrine events: GnRH and LH surges that are induced by positive feedback action of estrogen secreted by the mature ovarian follicles. The central mechanism of positive feedback action of estrogen on GnRH/LH secretion, however, is not fully understood yet. The present study ex... |
2,320,297 | Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation. | Choroid plexus (CP) produces the cerebrospinal fluid (CSF) of the central nervous system (CNS), but little is known about the mechanisms underlying development of this important tissue. CP forms in the hindbrain (4th ventricle), diencephalon (3rd ventricle) and dorsomedial telencephalon bilaterally (lateral ventricles)... |
2,320,298 | [A case of hepatocellular carcinoma complicating cardiac cirrhosis caused by constrictive pericarditis]. | Hepatocellular carcinoma (HCC) is one of the most common malignancies. Many factors are considered to be etiology associated with HCC; the important factors are hepatitis B and C viruses and alcohol. Cirrhosis is present in the majority of patients with HCC. It is assumed that all diseases, which lead to liver cirrhosi... |
2,320,299 | Myocardial first-pass perfusion assessment using rotational long-axis MRI. | To study a first-pass myocardial perfusion imaging method, such that long-axis imaging slices are obtained rotationally around the short-axis centroid of the left ventricular cavity, in order to improve myocardial coverage and better delineate the basal and apical myocardium.</AbstractText>This rotational long-axis (RL... |
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