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2,320,900 | Neuroendoscopic transventricular surgery for suprasellar cystic mass lesions such as cystic craniopharyngioma and Rathke cleft cyst. | Cystic mass lesions in the suprasellar cistern are often associated with neurological deficits, cognitive disorders, and endocrinological impairments. Many surgical approaches are available to treat these mass lesions, but are technically difficult and cannot remove the lesion completely without risking damage to neuro... |
2,320,901 | Maternal infection-induced white matter injury is reduced by treatment with interleukin-10. | The purpose of this study was to test the hypothesis that interleukin-10 can prevent white matter injury in neonatal rats that are born to infected dams.</AbstractText>Timed pregnant rats (day 17) were assigned to the following treatment groups: (1) saline control (n = 5 rats), (2) Escherichia coli- infected (n = 10 ra... |
2,320,902 | Neonatal cerebral white matter injury in preterm infants is associated with culture positive infections and only rarely with metabolic acidosis. | Neonatal cerebral white matter injury represents a major precursor for neurological impairment and cerebral palsy. Our objective was to identify risk factors associated with its development.</AbstractText>This retrospective case-control study of all births between 23 and 34 weeks gestation at a single university hospit... |
2,320,903 | ADC mapping of normal human brain. | The quantification of diffusion conditions in normal human brain has been gaining more and more attention since diffusion weighted imaging (DWI) was proved to be an important tool in the evaluation of cerebral pathologies, especially regarding the diagnosis of hyperacute stroke. The purpose of this study was to investi... |
2,320,904 | MCP-1 induces migration of adult neural stem cells. | As a model for brain inflammation we previously studied transcriptional profiles of tumor necrosis factor-alpha (TNF)treated U373 astroglioma cells. In previous work we were able to demonstrate that the chemokine monocyte chemoattractant protein-1 (MCP-1, SCYA2, CCL2, MCAF) expression in U373 cells was inducible by TNF... |
2,320,905 | Subependymal giant cell tumors in tuberous sclerosis complex. | To describe the clinical presentations, radiologic features, and postoperative outcomes of a clinic-based population of patients with subependymal giant cell tumors (SGCT) and tuberous sclerosis complex (TSC) and to redefine and reclassify SGCT based on radiologic, clinical, and pathologic criteria.</AbstractText>Of 13... |
2,320,906 | Hypothesis about the physiopathology of acute deterioration and sudden death caused by colloid cysts of the third ventricle. | In this paper, the authors review the mechanisms of acute deterioration and sudden death caused by colloid cysts (CCs). These dreaded events are widely recognized complications of CC, however the mechanism(s) in cause has been subject to controversy. Increased intracranial pressure (ICP) is a common event associated wi... |
2,320,907 | The low molecular weight inhibitor of NCX1 interacts with a cytosolic domain that differs from the ion-transport site of the Na/Ca exchanger. | The endogenous inhibitory factor (NCX(IF)) of the cardiac Na/Ca exchanger (NCX1) is a low molecular weight substance, which has a strong capacity to modulate the ventricle muscle contractility. Previously, we have shown that NCX(IF) can completely inhibit either the forward (Na(i)-dependent Ca-uptake) or reverse (Na(o)... |
2,320,908 | [Changes of amino acid content in hippocampus of epileptic rats treated with volatile oil of Acorus tatarinowii]. | To study the changes of excitatory and inhibitory amino acid content in hippocampus of epileptic rats treated with volatile oil of A. tatarinowii, and explore the possible antiepiletic mechanism.</AbstractText>The volatile oil was extracted through Supercritical-CO2 Fluid Extraction (SFE-CO2), and epileptic models were... |
2,320,909 | Long-term survival following treatment of multiple supra- and infratentorial aspergillus brain abscesses. | Aspergillus brain abscess is a rare but frequently fatal disease. Despite the scarcity of reported survivors, a combination of medication and surgical treatment might be effective. We report a 37-year-old man who developed multiple aspergillus brain abscesses after severe bacterial pneumonia. The following strategy was... |
2,320,910 | In vivo structural imaging of the rat brain with a 3-T clinical human scanner. | To examine the feasibility of using product acquisition software on a 3-T human MRI system to acquire high-resolution structural brain images in the rat.</AbstractText>Three sets of dual spin-echo, high-resolution (0.234 x 0.234 mm in-plane, 0.5 mm thick) images covering the entire rat brain were collected and averaged... |
2,320,911 | Giant intracerebral choroid plexus calcification. | While small calcifications of the choroid plexus are frequent, a large, single intracerebral calcification originating from the choroid plexus is rare. This report presents a 27-year-old woman who was admitted because of right temporal headache which had persisted for months. There was no neurological deficit. Computed... |
2,320,912 | Serial evaluation of diffusion tensor brain fiber tracking in a patient with severe diffuse axonal injury. | Serial evaluation of diffusion tensor brain fiber tracking was performed in a 27-year-old female patient with diffuse axonal injury after a traffic accident. Although the result of brain fiber tracking was not necessarily parallel to her clinical symptoms, it may have predicted the neurologic prognosis. |
2,320,913 | Increased intracranial volume: a clue to the etiology of idiopathic normal-pressure hydrocephalus? | The etiology of idiopathic normal-pressure hydrocephalus (NPH) is unknown. The purpose of this study was to examine the hypothesis that NPH begins in infancy as benign external hydrocephalus due to decreased uptake of CSF by the arachnoid villi. Since this occurs before the sutures fuse, a secondary hypothesis is that ... |
2,320,914 | Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody. | Ciliated ependymal cells line the ventricular surfaces and aqueducts of the brain. In ex vivo experiments, pneumolysin caused rapid inhibition of the ependymal ciliary beat frequency and caused ependymal cell disruption. Wild-type pneumococci and pneumococci deficient in pneumolysin caused ciliary slowing, but penicill... |
2,320,915 | The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCs) in the choroid plexus and microvasculature of the brain. | In the brain, utrophin is present in the choroid plexus epithelium and vascular endothelial cells, whereas the short C-terminal isoform of dystrophin (Dp71) is localized in the glial end-feet surrounding blood vessels. Both proteins serve as anchors for the so-called dystrophin-associated protein complex (DPC), compose... |
2,320,916 | An animal model of chronic placental insufficiency: relevance to neurodevelopmental disorders including schizophrenia. | Evidence now suggests that compromised prenatal brain development may increase the risk for the manifestation of neurological disorders such as schizophrenia. We present a guinea-pig model which mimics a condition of human pregnancy, namely, chronic placental insufficiency. Previously we reported that at term there are... |
2,320,917 | Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. | Insulin is mainly known for its peripheral effects on the metabolism of glucose, fats, and proteins. However, insulin also exerts important actions within the brain, and functions as a neuropeptide. The brain can thus be regarded as both an insulin-sensitive and a glucose-sensitive organ. Its neuroanatomical basis is t... |
2,320,918 | Expert knowledge-guided segmentation system for brain MRI. | We describe an automated 3-D segmentation system for in vivo brain magnetic resonance images (MRI). Our segmentation method combines a variety of filtering, segmentation, and registration techniques and makes maximum use of the available a priori biomedical expertise, both in an implicit and an explicit form. We approa... |
2,320,919 | Slc26a6: a cardiac chloride-hydroxyl exchanger and predominant chloride-bicarbonate exchanger of the mouse heart. | Bicarbonate facilitate more than 50% of pH recovery in the acidotic myocardium, and have roles in cardiac hypertrophy and steady-state pH regulation. To determine which bicarbonate transporters are responsible for this activity, we measured the expression levels of all known HCO3(-)-anion exchange proteins in mouse hea... |
2,320,920 | Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice. | To determine the importance of PEPT2 in the uptake of glycylsarcosine (GlySar) and 5-aminolevulinic acid (5-ALA) in mouse choroid plexus whole tissue.</AbstractText>Uptake studies were performed in bicarbonate artificial cerebrospinal fluid buffer using choroid plexuses isolated from PEPT2+/+ and PEPT2-/- mice. [14C]Gl... |
2,320,921 | Experimental autoimmune encephalomyelitis (EAE): lesion visualization on a 3 Tesla clinical whole-body system after intraperitoneal contrast injection. | To investigate the intravital visibility of CNS lesions in rats with experimental autoimmune encephalomyelitis (EAE), the animal correlate of multiple sclerosis, using a 3-Tesla (T) whole-body MR system.</AbstractText>Three healthy Dark Agouti (DA) rats and 16 DA rats with clinical signs of EAE were examined on a 3T wh... |
2,320,922 | The subfornical organ is the primary locus of sodium-level sensing by Na(x) sodium channels for the control of salt-intake behavior. | Dehydration causes an increase in the sodium (Na) concentration and osmolarity of body fluid. For Na homeostasis of the body, controls of Na and water intake and excretion are of prime importance. However, the system for sensing the Na level within the brain that is responsible for the control of Na- and water-intake b... |
2,320,923 | Ventricular injury following cranial gunshot wounds: clinical study. | Gunshot wounds to the head are usually fatal injuries, despite all medical and surgical interventions. Ventricular injury is a poor prognostic factor-for penetrating cranial gunshot wounds. Intraventricular hemorrhage and ventricular lacerations are the main components of such injuries. The incidence, management, and o... |
2,320,924 | Linear parameters of normal and abnormal cava septi pellucidi: a post-mortem study. | Anatomical variations in the dimensions of different brain structures have been correlated with clinical syndromes. This study on the parameters of normal and abnormal cavum septi pellucidi (CSP) can be of clinical significance. We obtained 479 brains from autopsied persons (310 males and 169 females, 377 normal or asy... |
2,320,925 | Desmoplastic infantile ganglioglioma: a rare tumor with an unusual presentation. | Desmoplastic infantile ganglioglioma (World Health Organization grade I) is a rare neoplasm. Despite their common large size and spectacular radiologic and histologic features, the prognosis after surgical resection is good. We present a new case of this tumor in a 14-month-old boy with a recent history of intracranial... |
2,320,926 | Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35). | The effects of (+) securinine on behavior and morphological changes after intracerebral ventricle injection of beta-amyloid (25-35) (Abeta(25-35)) in rats were investigated. A single high dose of Abeta(25-35) could impair the spatial cognitive function. The latency of locating the platform was longer in the model group... |
2,320,927 | Rupture of totally implantable central venous access devices (Intraports) in patients with cancer: report of four cases. | Totally implantable central venous access devices (intraports) are commonly used in cancer patients to administer chemotherapy or parenteral nutrition. Rupture of intraport is a rare complication.</AbstractText>During 3 years period, a total of 245 intraports were placed in cancer patients for chemotherapy. Four of the... |
2,320,928 | [Effects of cyclovirobuxine D on intracellular Ca2+ and L-type Ca2+ current in rat ventricular cardiomyocytes]. | To determine the effects of cyclovirobuxine D (CD) on intracellular Ca2+ mobilization and L-type Ca2+ current (I(Ca-L)) in isolated rat cardiomyocytes.</AbstractText>The effects of CD on the amplitude of I(Ca-L) and intracellular Ca2+ mobilization induced by KCl and caffeine were studied with the method of patch-clamp ... |
2,320,929 | Analysis of 3-D myocardial motion in tagged MR images using nonrigid image registration. | Tagged magnetic resonance imaging (MRI) is unique in its ability to noninvasively image the motion and deformation of the heart in vivo, but one of the fundamental reasons limiting its use in the clinical environment is the absence of automated tools to derive clinically useful information from tagged MR images. In thi... |
2,320,930 | Cavernous lymphangioma in the laryngeal ventricle in an adult patient. | Lymphangiomas of the larynx are quite rare and even rarer in adults. Isolated cavernous lymphangioma in the laryngeal ventricle was diagnosed in a 47-year-old woman. The patient presented with hoarseness with a history of three months. Direct laryngoscopy performed under general anesthesia showed a large, smooth, gray-... |
2,320,931 | Specific AHNAK expression in brain endothelial cells with barrier properties. | The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and low permeability. Because disruption of the BBB may contribute to many brain disorders, they are of considerable interests in the identification of the molecular mechanisms of BBB development and integrity. We here report that the giant pr... |
2,320,932 | Differentiation of bone marrow stromal cells into the cardiac phenotype requires intercellular communication with myocytes. | Bone marrow stromal cells (BMSCs) have the potential to differentiate into various cells and can transdifferentiate into myocytes if an appropriate cellular environment is provided. However, the molecular signals that underlie this process are not fully understood. In this study, we show that BMSC differentiation is de... |
2,320,933 | [Analysis of gene expression profiles in heart tissues from two breeds of pigs]. | To study the expression profiles in the heart tissues of domestic pigs,five un-normalized cDNA libraries from Danish adult female Landrace heart, biceps femoris, aorta, left ventricle tissues and Chinese adult female Erhualian heart tissue were constructed. Totally 35 180 expressed sequence tags (ESTs) were randomly se... |
2,320,934 | [Echocardiographic features in a case of tuberculous lymphadenitis].<Pagination><StartPage>539</StartPage><EndPage>543</EndPage><MedlinePgn>539-43</MedlinePgn></Pagination><Abstract><AbstractText>Tuberculosis can secondarily affect the heart, mainly the pericardium and less frequently the endocardium and coronary vesse... | Tuberculosis can secondarily affect the heart, mainly the pericardium and less frequently the endocardium and coronary vessels. Tuberculous myocarditis usually is a post-mortem diagnosis, and affects the right atrium and left ventricle presenting as miliary granulomas with or without caseating necrosis, or as diffuse c... |
2,320,935 | On the value of geometry-based models for left ventricular volumetry in magnetic resonance imaging and electron beam tomography: a Bland-Altman analysis. | Methodological comparison of ellipsoid model-based approaches and Simpson method to evaluate left ventricular volumetric parameters by magnetic resonance (MR) and electron beam tomography (EBT) and analysis of the origin of possible discrepancies.</AbstractText>100 subjects (87 patients, 13 healthy volunteers) were stu... |
2,320,936 | Cloning of the mismatch recognition protein MSH2 from zebrafish (Danio rerio) and its developmental stage-dependent mRNA expression. | Eukaryotic mismatch repair of simple base mispairs and small insertion-deletion loops is activated by the binding of a heterodimeric complex composed of MutS homolog 2(MSH2) and MSH6. Here we report the cloning of zebrafish (Danio rerio) MSH2 (zMSH2) cDNA that has an open reading frame of 2811 nucleotides encoding a po... |
2,320,937 | Reinforcing aspects of androgens. | Are androgens reinforcing? Androgenic-anabolic steroids (AAS) are drugs of abuse. They are taken in large quantities by athletes and others to increase performance, often with negative long-term health consequences. As a result, in 1991, testosterone was declared a controlled substance. Recently, Brower [K.J. Brower, A... |
2,320,938 | Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus. | Arcuate neurokinin B (NKB) neurons express estrogen receptor-alpha and are strongly modulated by gonadal steroids. Although numerous studies suggest that NKB neurons participate in the reproductive axis, there is no information on the regulation of luteinizing hormone (LH) secretion by NKB or its receptor, NK3. In the ... |
2,320,939 | Automated morphometric study of brain variation in XXY males. | This paper studies brain morphometry variation associated with XXY males (Klinefelter's syndrome) by using an automated whole-brain volumetric analysis method. The application to 34 XXY males and 62 normal male controls reveals pronounced volume reduction in the brains of XXY males, relative to the brains of normal con... |
2,320,940 | Laparoscopic excision of a gastric duplication cyst detected on antenatal ultrasound scan. | The authors report a gastric duplication cyst detected antenatally and its subsequent laparoscopic removal at 2 months of age. Before birth, a cystic mass was detected behind the stomach on fetal ultrasound scan (US). After birth, an US, barium meal, nuclide scan, and cervical and thoracic vertebral x-rays suggested th... |
2,320,941 | Active clearance of human amyloid beta 1-42 peptide aggregates from the rat ventricular system. | A major constituent of SP in the brains of Alzheimer's disease is 39-43 amino acid peptide called beta-amyloid peptide (Abeta). Recent data have demonstrated that Abeta has a strong tendency to form insoluble aggregates and that toxic effects of Abeta is based on its aggregation. In the current study, 100 microg of hum... |
2,320,942 | Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. | We examined the cell proliferative, neurogenic, and behavioral effects of transforming growth factor alpha (TGFalpha) in a 6-OHDA Parkinson's disease model when compared with naive rats. Intrastriatal TGFalpha infusion induced significant proliferation, hyperplastic nodules, and substantial migratory waves of nestin-po... |
2,320,943 | Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat. | Fatty acid amides and fatty acid ethanolamides are novel signalling molecules exemplified by the sleep-inducing lipid oleamide and the endocannabinoid anandamide, respectively. These substances are inactivated by fatty acid amide hydrolase (FAAH), an enzyme that is expressed by neurons and non-neuronal cells in the bra... |
2,320,944 | Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome. | Regulation of the hypothalamic-pituitary-thyroid (HPT) axis is dependent upon the secretion of thyrotropin-releasing hormone (TRH), a tripeptide originating in the hypothalamic paraventricular nucleus (PVN). These so-called hypophysiotropic neurons are under feedback inhibition by circulating levels of thyroid hormone,... |
2,320,945 | Differential patterns of cognitive impairment in patients with aqueductal stenosis and normal pressure hydrocephalus. | We report a preoperative neuropsychological evaluation for ten adult patients with aqueductal stenosis, and compare the results of this group with a normal pressure hydrocephalus group.</AbstractText>For executive functions, aqueductal stenosis patients failed on isolated tests and results were heterogeneous; the norma... |
2,320,946 | Comparison of the small heat shock proteins alphaB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle. | Seven members of the small heat shock protein (sHSP) family are exceptional with respect to their constitutive high abundance in muscle tissue. It has been suggested that sHSPs displaying chaperone-like properties may stabilize myofibrillar proteins during stress conditions and prevent them from loss of function. In th... |
2,320,947 | Multiplanar functional imaging of the larynx and hypopharynx with multislice spiral CT. | The purpose of this study is to evaluate multislice spiral CT (MSCT) in multiplanar functional imaging of the larynx and hypopharynx and to define the optimal image planes for the delineation of the tumor and specific anatomical structures. Forty patients with suspected tumors of the larynx or hypopharynx were examined... |
2,320,948 | Familial colloid cysts of the third ventricle. | A father and daughter with colloid cysts of the third ventricle are described. The nine previously reported examples of familial occurrence are reviewed, and the conclusion is reached that inheritance is likely autosomal dominant. The proportion of all cases which are genetic is not known. A plea is made for routine de... |
2,320,949 | Clozapine blocks sympathetic and thermogenic reactions induced by orexin A in rat. | This experiment tested the effect of clozapine on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures were monitored in urethane-anesthetized male Sprague-Dawley rats before and for... |
2,320,950 | Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-Abeta antibody into the third ventricle of TgCRND8 mice. | We have previously shown that anti beta-amyloid (Abeta) antibody injected into the third ventricle of mice is distributed throughout the brain within 24 hr and is completely washed out of brain within 36 hr after injection and that, in Tg2576 animals, a single injection of antibody reduces cerebral Abeta and restores p... |
2,320,951 | Effects of urocortin 2 and 3 on motor activity and food intake in rats. | Urocortin 2 (Ucn 2) and Ucn 3 are new members of the corticotropin-releasing factor (CRF) family and bind selectively to the CRF type 2 receptor (CRF2). The effects of these peptides on behavioral changes induced by CRF were examined in rats. In a familiar environment, intracerebroventricular injection of Ucn 2 attenua... |
2,320,952 | Increased 5-HT2A receptor expression and function following central glucocorticoid receptor knockdown in vivo. | Central glucocorticoid receptor function may be reduced in depression. In vivo modelling of glucocorticoid receptor underfunctionality would assist in understanding its role in depressive illness. The role of glucocorticoid receptors in modulating 5-HT(2A) receptor expression and function in the central nervous system ... |
2,320,953 | Long term follow-up in a patient with papillary glioneuronal tumor. | We report a case of a young female patient with a rare and recently described form of brain tumor. This patient had a history of headache, hemiparesis and motor simple partial seizures. Her investigation revealed a brain tumor involving the left frontal and parietal lobes. The radiological images showed a cystic mass w... |
2,320,954 | Signals and mechanisms of compensatory lung growth. | Growth of the lung involves unique structure-function interactions not seen in solid organs. Mechanical feedback between the lung and thorax constitutes a major signal that sustains developmental as well as compensatory lung growth. After the loss of lung units as by pneumonectomy (PNX), increased mechanical stress and... |
2,320,955 | New onset seizures in pregnancy caused by an unexpected neurologic disorder. | Seizures in pregnancy are a life-threatening emergency that continues to be a major cause of serious maternal and fetal morbidity and mortality. We report a rare cause of new onset of seizures in pregnancy: hydrocephalus caused by aqueductal stenosis. The differential diagnosis of seizures in pregnancy is discussed in ... |
2,320,956 | SVZa neural stem cells differentiate into distinct lineages in response to BMP4. | Neural stem cells (NSCs) reside in the anterior portion of the forebrain subventricular zone (SVZa) and generate the progenitors which will differentiate into neurons, and via a tangential migratory pathway, known as the rostral migratory stream (RMS), migrate to the olfactory bulbs (OB). Bone morphogenetic proteins (B... |
2,320,957 | Relationship between growth hormone (GH) pulses in the peripheral circulation and GH-releasing hormone and somatostatin profiles in the cerebrospinal fluid of goats. | Growth hormone (GH) is secreted in a pulsatile manner, but the underlying mechanisms of GH pulse generation remain to be resolved. In the present study, we investigated the relationship between GH pulses in the peripheral circulation and GH-releasing hormone (GHRH) and somatostatin (SRIF) profiles in the cerebrospinal ... |
2,320,958 | Subependymoma in the third ventricle in a child. | Subependymomas are rare, slow-growing, benign intraventricular tumors which occur commonly in the fourth or lateral ventricle. They usually occur in elderly men and often are asymptomatic and discovered incidentally. We report a case of a 6-year-old girl with a symptomatic subependymoma in the third ventricle with MR i... |
2,320,959 | Fine structural correlates of the choroid plexus of the lateral cerebral ventricle of the human fetal brain. | The germinal matrix neuroepithelium and the choroidal fissure of the fetal choroid plexus commonly possess microvessels that are often poorly developed. There may be a reduction of type IV collagen that surrounds these fragile microvessels. During the first and second trimester of neural development, these microvessels... |
2,320,960 | Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice. | The olfactory bulb plays a critical role in odor discrimination and in processing olfactory cues controlling social behavior in mammals. Given that the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1) is highly expressed in the olfactory bulb, we examined its role in regulating olfactio... |
2,320,961 | Transcription of SCO-spondin in the subcommissural organ: evidence for down-regulation mediated by serotonin. | The subcommissural organ (SCO) is a brain gland located in the roof of the third ventricle that releases glycoproteins into the cerebrospinal fluid, where they form a structure known as Reissner's fiber (RF). On the basis of SCO-spondin sequence (the major RF glycoprotein) and experimental findings, the SCO has been im... |
2,320,962 | [A comparative analysis of regulatory regions of the transthyretin gene in the mouse, human, and chimpanzee genomes]. | A full genome analysis of differences between the gene expression in the human and chimpanzee brains revealed that the gene for transthyretin, the carrier of thyroid hormones, is differently transcribed in the cerebella of these species. A 7-kbp DNA fragment of chimpanzee was sequenced to identify possible regulatory s... |
2,320,963 | [Clinical features and physical fitness parameters in athletes with cardiac connective tissue dysplasia syndrome].<Pagination><StartPage>44</StartPage><EndPage>48</EndPage><MedlinePgn>44-8</MedlinePgn></Pagination><Abstract><AbstractText>Seventy-seven athletes with different manifestations of the cardiac connective tis... | Seventy-seven athletes with different manifestations of the cardiac connective tissue dysplasia (CCTD) syndrome (mitral prolapse (MP), anomalously located chordae (ALC) of the left ventricle and/or their combination) and 23 athletes without signs of CCTD syndrome were examined. The purpose of the study was to determine... |
2,320,964 | Neural responses to territorial challenge and nonsocial stress in male song sparrows: segregation, integration, and modulation by a vasopressin V1 antagonist. | The present experiments were conducted to determine (1) which basal forebrain regions and/or their peptidergic components are responsive to social challenge and nonsocial stress, and (2) the influence of an arginine vasopressin V(1) antagonist (AVPa) on these responses. Experiments were conducted in wild-caught male so... |
2,320,965 | Expression of fascin-1, the gene encoding the actin-bundling protein fascin-1, during mouse embryogenesis. | Fascin-1 is an actin-bundling protein that contributes to the architecture and function of cell protrusions and microfilaments in cell adhesion, interactions and motility. Fascin-1 has been studied in cultured cells and by biophysical methods, but little is known about its distribution and functions in vertebrate devel... |
2,320,966 | MRI of the brainstem in patients with major depression, bipolar affective disorder and normal controls. | Structural imaging studies of bipolar affective disorder or major depression have shown a spectrum of abnormal findings. However, a characteristic pattern of abnormality for either disease has not yet emerged. While the majority of studies focused on brain atrophy and the volumes of supratentorial cerebral structures, ... |
2,320,967 | Cardiovascular responses to microinjection of L-glutamate into the NTS in AV3V-lesioned rats. | The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic ... |
2,320,968 | GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. | Normal heart development is orchestrated by a set of highly conserved transcription factors that includes GATA4, Nkx2-5, and Tbx5. Heterozygous mutation of each of these genes causes congenital heart disease in humans. In mouse models, haploinsufficiency for Nkx2-5 or Tbx5 resulted in an increased incidence of structur... |
2,320,969 | Adult neural stem cells from the mouse subventricular zone are limited in migratory ability compared to progenitor cells of similar origin. | The subventricular zone (SVZ) in the forebrain is the largest source of neural stem cells and progenitor cells in the adult CNS. To assess the ability of adult neural stem cells to survive, differentiate and migrate, we have compared the behavior of dissociated, neurosphere-derived stem cells with that of progenitor ce... |
2,320,970 | Expression of the secreted factors noggin and bone morphogenetic proteins in the subependymal layer and olfactory bulb of the adult mouse brain. | The antagonism between noggin and the bone morphogenetic proteins (BMPs) plays a key role during CNS morphogenesis and differentiation. Recent studies indicate that these secreted factors are also widely expressed in the postnatal and adult mammalian brain in areas characterized by different types of neural plasticity.... |
2,320,971 | Toosendanin, a triterpenoid derivative, acts as a novel agonist of L-type Ca2+ channels in neonatal rat ventricular cells. | Toosendanin, a triterpenoid derivative extracted from Melia toosendan Sieb et Zucc, was demonstrated to be potentially useful in medical and scientific researches. Here, we investigated the effects of toosendanin on L-type voltage-dependent Ca(2+) channels in cultured neonatal rat ventricular cells, using whole-cell pa... |
2,320,972 | Widespread gene transduction to the central nervous system by adenovirus in utero: implication for prenatal gene therapy to brain involvement of lysosomal storage disease. | In some lysosomal storage diseases, considerable alterations of the central nervous system (CNS) occur prior to birth and neurodegeneration progresses rapidly soon after birth causing early death in patients. No effective treatment is available after birth. Treatment may need to be initiated before birth to prevent the... |
2,320,973 | Association of a fetal quadrigeminal cyst with a possibly congenital thalamic astrocytoma. | This article reports on the exceptional association of a fetal quadrigeminal malformative cyst with a possibly congenital pilocytic astrocytoma of the pulvinar. Both the cyst and the tumor required treatment due to their postnatal growth.</AbstractText>Treatment modalities and difficulties are emphasized, as well as th... |
2,320,974 | Retrospective analysis of post-hemorrhagic ventricular dilatation in very low birth weight infants, short and long-term outcome. | The aim of this paper was to study the evolution of ventriculomegaly, the treatment and the developmental problems of a group of very low birth weight infants (VLBWI) born between 1985 and 1999 who met Levene's percentiles for post-hemorrhagic ventricular dilatation (PHVD).</AbstractText>A retrospective hospital-based ... |
2,320,975 | Third heart sound: genesis and clinical importance. | Auscultation of third heart sound has been performed for more than a century, an interest that not only persists today, but also has experienced renewed emphasis. Sophisticated study of the third heart sound by current investigative techniques has underscored the value of clinical detection with the time-honored stetho... |
2,320,976 | Possible oncogenicity of subventricular zone neural stem cells: case report. | The origin of brain tumors has attracted much controversy. Recent advances in neural stem cell biology coupled with the new concepts of central nervous system development have raised interesting possibilities regarding the oncogenic properties of neural stem/progenitor cells. To elucidate these putative properties furt... |
2,320,977 | A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth. | We evaluated a 9-amino-acid peptide, SALLRSIPA (SAL), an agonist of activity-dependent neurotrophic factor (ADNF), for its protective properties against fetal alcohol-related brain growth retardation, using an established liquid diet model of alcohol-related neurodevelopmental disorder (ARND) in C57BL/6 mice. Alcohol e... |
2,320,978 | Latencies of climbing fiber inputs to turtle cerebellar cortex. | Responses of separate regions of rat cerebellar cortex (Cb) to inferior olive (IO) stimulation occur with the same latency despite large differences in climbing fiber (CF) lengths. Here, the olivocerebellar path of turtle was studied because its Cb is an unfoliated sheet on which measurements of latency and CF length c... |
2,320,979 | Management of normal pressure hydrocephalus. | Gait instability, urinary incontinence, and dementia are the signs and symptoms typically found in patients who have normal pressure hydrocephalus. Estimated to cause no more than 5 percent of cases of dementia, normal pressure hydrocephalus often is treatable, and accurate recognition of the clinical triad coupled wit... |
2,320,980 | Realistic Virtual Endoscopy of the ventricle system and haptic-based surgical simulator of hydrocefalus treatment. | New methods and software tools for automatic extraction of the ventricle system from magnetic resonance imagery (MRI) data, ventricle part classification, and realistic texturing are proposed to support Virtual Endoscopy (VE). Volume- and surface-based medical atlases are intensively used as templates in the methods. T... |
2,320,981 | Postural intermittent headaches as the initial symptom of a cavernoma in the third ventricle. | Cavernous malformations (CM) occur very rarely in the ventricular system. We report a patient with a rare location in the third ventricle who had intermittent headaches as the initial symptom. |
2,320,982 | Laryngeal amyloidosis in 10 patients. | Review the location, symptoms, treatment, and outcomes in 10 consecutive laryngeal amyloid (LA) patients.</AbstractText>Pre and retrospective evaluation after treatment.</AbstractText>Analysis of visual and phonatory pathology and detailed description of surgery.</AbstractText>Amyloid on the undersurface of both true v... |
2,320,983 | Audiovestibular evolution in a patient with multiple sclerosis. | Multiple sclerosis is characterized by the presence of multiple plaques within the central nervous system, manifesting as remission and exacerbation of neurologic dysfunction over variable time courses. We present the case of a 20-year-old woman. Before treatment, her auditory brain stem response (ABR) test revealed bi... |
2,320,984 | Uptake and metabolism of serotonin by ependymal primary cultures. | Serotonin uptake and metabolism was studied in ependymal primary cultures. Serotonin uptake was facilitated by two different systems, one of which was the neuronal serotonin transporter SERT, exhibiting a Vmax value of 3.8+/-0.1 pmol x min(-1) x (mg protein)(-1) and an apparent Michaelis-Menten constant of 0.41+/-0.03 ... |
2,320,985 | Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. | Little is known about how neurons in the different layers of the mammalian cerebral cortex are specified at the molecular level. Expression of two homologues of the Drosophila homeobox Cut gene, Cux-1 and Cux-2, is strikingly specific to the pyramidal neurons of the upper layers (II-IV) of the murine cortex, suggesting... |
2,320,986 | Distribution of zincergic neurons in the mouse forebrain. | Synaptically released zinc is thought to play an important role in neuronal signaling by modulating excitatory and inhibitory receptors and intracellular signaling proteins. Consequently, neurons that release zinc have been implicated in synaptic plasticity underlying learning and memory as well as neuropathological pr... |
2,320,987 | Pathomorphological criteria for cardiosclerosis and angioarchitectonics of the hypertrophic myocardium in hypertensive heart. | We performed a pathomorphological study of 200 hearts with cicatricial changes from patients died from hypertensive disease. Most postinfarction scars in men were transmural and localized in the anterior and posterior wall of the left ventricle and in the interventricular septum. Non-transmural scars were revealed in t... |
2,320,988 | Expression of thyroid transcription factor 1 in primary brain tumours. | Thyroid transcription factor 1 (TTF-1) is expressed in a proportion of carcinomas derived from follicular thyroid cells and respiratory epithelium. Immunohistochemical detection of this protein was shown previously to be a helpful aid in tumour diagnosis, specifically in deciding whether a tumour is primary to the lung... |
2,320,989 | Regional expression of the radial glial marker vimentin at different stages of the kindling process. | The classical view of the function of radial glia in brain development is a supporting function guiding radial neural migration. However, recent evidence indicates that they may play key roles in neurogenesis and gliogenesis, as ubiquitous precursors that generate neurons and glia. Although we previously reported the e... |
2,320,990 | Midkine and retinoic acid reduce cerebral infarction induced by middle cerebral artery ligation in rats. | The present study investigates the neuroprotective effects of midkine (MK) and retinoic acid (RA) against ischemia in the CNS. Primary cortical neurons, derived from rat E15 embryos (DIV9), were treated with 9-cis-RA (9cRA), all-trans-RA (atRA) or vehicle. Using quantitative PCR, the level of MK mRNA was significantly ... |
2,320,991 | Bobble head doll syndrome in a child with a third ventricular cyst and hydrocephalus. | The bobble head doll syndrome, mainly affecting children under 10 years of age, is a rare and surgically treatable movement disorder characterized by head bobbing occurring at a rate of 2-3 times/s. Its pathophysiological mechanism is not well known but two main factors are commonly associated with the condition: a dil... |
2,320,992 | Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. | It has been postulated that specialized glucose-sensing neurons in the ventromedial hypothalamus (VMH) are able to detect falling blood glucose and trigger the release of counterregulatory hormones during hypoglycemia. The molecular mechanisms used by glucose-sensing neurons are uncertain but may involve cell surface A... |
2,320,993 | Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin. | Recent evidence demonstrates that hypothalamic insulin signaling is required for inhibition of endogenous glucose production. The downstream mechanisms that are responsible for the effects of hypothalamic insulin receptor activation on hepatic fuel flux remain to be determined. To establish whether downregulation of ne... |
2,320,994 | Genetic and expression profiles of cerebellar liponeurocytomas. | Cerebellar liponeurocytoma, a rare, newly identified CNS neoplasm of adults, is characterized by advanced neuronal/neurocytic and focal lipomatous differentiation, low proliferative potential and a favorable clinical prognosis. Despite the different age distribution and benign biological behavior, the cerebellar lipone... |
2,320,995 | Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. | Hypoxia as well as global and focal ischemia are strong activators of neurogenesis in the adult mammalian central nervous system. Here we show that the hypoxia-inducible vascular endothelial growth factor (VEGF) and its receptor VEGFR-2/Flk-1 are expressed in clonally-derived adult rat neural stem cells in vitro. VEGF ... |
2,320,996 | Antenatal diagnosis of central nervous system anomalies: can we predict prognosis? | Our technical ability to diagnose fetal anomalies of the central nervous system by ultrasonography and by fetal magnetic resonance imaging far exceeds our current knowledge of their possible neurodevelopmental implications later in life. This limitation often makes obstetric and clinical decisions very difficult. We re... |
2,320,997 | Dominance-related changes in spatial memory are associated with changes in hippocampal cell proliferation rates in mountain chickadees. | It is well established that spatial memory is dependent on the hippocampus in both mammals and birds. As memory capacity can fluctuate on a temporal basis, it is important to understand the mechanisms mediating such changes. It is known that early memory-dependent experiences in young animals result in hippocampal enla... |
2,320,998 | Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus. | 2,4-Dichlorophenoxyacetic acid (2,4-D) is an anionic herbicide. The purpose of the present study is to examine whether organic anion transporter 3 (Oat3; Slc22a8) is solely responsible for the uptake of 2,4-D by the isolated rat choroid plexus (CP). When expressed in LLC-PK1 cells, rOat3 was mainly localized to the bas... |
2,320,999 | Distinct migratory behavior of early- and late-born neurons derived from the cortical ventricular zone. | Time-lapse studies indicate that ventricular zone (VZ)-derived cells show two migratory modes in the cerebral cortex at different stages of mammalian embryogenesis: somal translocation and locomotion. We carried out a systematic analysis to examine whether the migratory behavior of cortical neurons derived from the cor... |
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