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2,321,800 | Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. | Neurofibrillary tangles (NFTs) consisting of the hyperphosphorylated microtubule-associated protein tau are a defining pathological characteristic of Alzheimer's disease (AD). Hyperphosphorylation of tau is hypothesized to impair the microtubule stabilizing function of tau, leading to the formation of paired helical fi... |
2,321,801 | In vivo monitoring of tumor relapse and metastasis using bioluminescent PC-3M-luc-C6 cells in murine models of human prostate cancer. | We used the bioluminescent human prostate carcinoma cell line PC-3M-luc-C6 to non-invasively monitor in vivo growth and response of tumors and metastasis before, during and after treatments. Our goal was to determine the utility of a luciferase-based prostate cancer animal model to specifically assess tumor and metasta... |
2,321,802 | Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling. | The circadian clock in the suprachiasmatic nucleus (SCN) is thought to drive daily rhythms of behaviour by secreting factors that act locally within the hypothalamus. In a systematic screen, we identified transforming growth factor (TGF)alpha as a likely SCN inhibitor of locomotion. TGFalpha is expressed rhythmically i... |
2,321,803 | Isolated mild fetal ventriculomegaly. | Ventriculomegaly is an excess of fluid in the lateral ventricles within the developing cerebrum. It is usually diagnosed at a routine fetal anomaly scan at 18-22 weeks gestation. Management of the condition and counselling of parents are difficult, as the cause, absolute risk, and degree of resulting handicap cannot be... |
2,321,804 | [Effects of adrenomedullin and proadrenomedullin N-terminal 20 peptide, alone or in combination, on the rat hearts in vitro]. | To study the effects of adrenomedullin (ADM) and proadrenomedullin N-terminal 20 peptide (PAMP) alone or in combinations on the isolated rat hearts as well as the possible signaling pathways involved in their actions.</AbstractText>In isolated rat hearts the left ventricular pressure (LVP), LVP+/-dp/dtmax, coronary flu... |
2,321,805 | [MRI and in utero ventriculomegaly]. | Ventriculomegaly constitutes the major indication of fetal brain MRI. MRI is therefore of utmost importance to look for a cause through the depiction of criteria of malformations and through the definition of criteria of destructive lesions. Malformations and destructive lesions are the most common causes of ventricula... |
2,321,806 | Hydrocephalus with visual deficits in a cat. | A 22-month-old male Japanese mongrel cat with a history of dysuria and recurrent generalised tonic-clonic seizure was examined by neuro-opthalmological testing and computed tomography (CT). Vision testing revealed narrowing of the visual field in the right eye, and complete visual deficits in the left eye. Pupillary re... |
2,321,807 | A neurobehavioral screening of the ckr mouse mutant: implications for an animal model of schizophrenia. | A model of schizophrenia, the chakragati (ckr) mouse was serendipitously created as a result of a transgenic insertional mutation. The apparent loss-of-function of an endogenous gene produced mice that, when homozygous, displayed an abnormal circling behavior phenotype. To determine whether this phenotype could be corr... |
2,321,808 | Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes. | Diabetic cardiomyopathy is characterized by cardiac dysfunction and altered level/function of insulin-like growth factor I (IGF-I). Both endogenous and exogenous IGF-I have been shown to effectively alleviate diabetes-induced cardiac dysfunction and oxidative stress. This study was designed to examine the effect of car... |
2,321,809 | Acute myocardial infarction: disposition to the operating room? | Given their low incidence, mechanical complications of AMI represent a diagnostic and therapeutic challenge for the EP. When the panoply of medical interventions has reached its limitation, surgical treatment plays a role in the management of the patient who has AMI. For patients who have CS and severe compromise of my... |
2,321,810 | Leptin fails to reduce ethanol intake in Marchigian Sardinian alcohol-preferring rats. | Leptin, a hormone secreted by the adipocytes and involved in feeding and energy balance control, has been proposed to modulate alcohol craving in mice and humans. This study evaluated whether leptin modulates alcohol intake in Marchigian Sardinian alcohol-preferring (msP) rats. Rats were offered 10% ethanol either 2h p... |
2,321,811 | Reopening of L-type calcium channels in human ventricular myocytes during applied epicardial action potentials. | Present study was performed to compare the dynamics of human L-type calcium current (ICa,L) flowing during rectangular voltage pulses, voltage ramps, and action potentials (APs) recorded from epicardiac and endocardiac canine ventricular cells.</AbstractText>ICa,L was recorded in single myocytes isolated from undisease... |
2,321,812 | Anaesthesia for lung volume reduction surgery. | Lung volume reduction surgery is a surgical treatment for severe emphysema that is increasing in popularity. The aim is to reverse the hyperexpansion of the lungs that leads to expiratory airflow limitation, compromises the diaphragm and chest wall mechanics, and tamponades the right ventricle. Optimal patient selectio... |
2,321,813 | The prediction of postoperative hydrocephalus in patients with spina bifida. | The object was to derive a prediction rule for the development of postoperative hydrocephalus in patients with spina bifida by the measurement of cranial ventricular diameters using ultrasound.</AbstractText>Eighty-nine patients with spina bifida were studied prospectively. Each child had preoperative cranial ultrasoun... |
2,321,814 | Molecular cloning, functional analysis, and RNA expression analysis of connexin45.6: a zebrafish cardiovascular connexin. | In the vertebrate cardiovascular system, gap junctions function in intercellular communication essential for both the coordinated propagation of the heartbeat and the control of vasomotor responses in the vascular system. Connexins, the protein subunits of gap junctions, are coded by a multigene family. In this study, ... |
2,321,815 | Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. | Recently we found that electrophysiological (EP) heterogeneities between subepicardial and midmyocardial cells can form a substrate for reentrant ventricular arrhythmias. However, cell-to-cell coupling through gap junctions is expected to attenuate transmural heterogeneities between cell types spanning the ventricular ... |
2,321,816 | Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. | Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal cells in rat cortex over several generations, we show here that neurons are generated in two proliferative zones by distinct patterns... |
2,321,817 | Ascites in ventriculoperitoneal shunt. | To fetch out the factors responsible for ascites, following shunt CSF diversion in cases of intracarnial lesions. Four children developing ascites/abdominal psuedocyst following ventriculoperitoneal shunt were analyzed to see the factors responsible for such complication.</AbstractText>Records of 4 cases developing asc... |
2,321,818 | Is patient size important in dose determination and optimization in cardiology? | Patient dose determination and optimization have become more topical in recent years with the implementation of the Medical Exposures Directive into national legislation, the Ionising Radiation (Medical Exposure) Regulations. This legislation incorporates a requirement for new equipment to provide a means of displaying... |
2,321,819 | Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex. | Enlargement of the lateral ventricles is among the most frequently reported macroscopic brain structural changes in schizophrenia, although variable in extent and localization. The authors investigated whether ventricular enlargement is related to regionally specific volume loss.</AbstractText>High-resolution magnetic ... |
2,321,820 | Giant rhabdomyoma of the right ventricle. | A giant intrathoracic mass causing foetal dysrhythmias, polyhydramnios and foetal hydrops necessitated a caesarean section in a male infant of 35 weeks gestation. Despite the benign histology of cardiac rhabdomyomas and the observation of spontaneous regression, there may be significant associated morbidity and mortali... |
2,321,821 | Stem cells and nervous tissue repair: from in vitro to in vivo. | Recent development in stem cell biology has indicated a new possible approach for the treatment of neurological diseases. However, in spite of tremendous hope generated, we are still on the way to understand if the use of stem cells to repair mature brain and spinal cord is a reliable possibility. In particular, we kno... |
2,321,822 | New syndrome: focal dermal hypoplasia, morning glory anomaly, and polymicrogyria. | Regional skin hypoplasia has been described in several genetic syndromes, including focal dermal hypoplasia (FDH), microphthalmia with linear skin defects (MLS), oculocerebrocutaneous syndrome (OCCS), and terminal osseous dysplasia and pigmentary defects (TODP). All but OCCS have been reported to follow an X-linked inh... |
2,321,823 | Exercise training attenuated the PKB and GSK-3 dephosphorylation in the myocardium of ZDF rats. | Cardiac dysfunction is a severe secondary effect of Type 2 diabetes. Recruitment of the protein kinase B/glycogen synthase kinase-3 pathway represents an integral event in glucose homeostasis, albeit its regulation in the diabetic heart remains undefined. Thus the following study tested the hypothesis that the regulati... |
2,321,824 | Cortical spreading depression blocks the hyperthermic reaction induced by orexin A. | This experiment tested the effect of cortical spreading depression on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male... |
2,321,825 | The involvement of the blood-brain and the blood-cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain. | Leptin is a 16 kDa hormone that is produced by adipose tissue and has a central effect on food intake and energy homeostasis. The ability of leptin to cross the blood-brain and blood-cerebrospinal fluid (CSF) barriers and reach or leave the CNS was studied by the bilateral in situ brain perfusion and isolated incubated... |
2,321,826 | Glutathione monoethyl ester provides neuroprotection in a rat model of stroke. | Oxidative stress plays an important role in the development of tissue damage following transient focal cerebral ischaemia. Glutathione is a central component in the antioxidant defence of cells. We have previously shown a close association between mitochondrial glutathione loss and cell death following middle cerebral ... |
2,321,827 | Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis. | Brain transplantation of neural precursor cells (NPCs) has been proposed to enhance CNS regeneration. As the pathogenesis of most acute CNS diseases involves an inflammatory component, we studied whether NPC transplantation affects brain inflammation. Newborn rat multipotential NPCs were transplanted intraventriculary ... |
2,321,828 | Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension. | 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have been shown to prevent or reverse hypertrophy of the LV in several models of left ventricular hypertrophy. The aim of the present study was to determine whether treatment with simvastatin can prevent hypertension, reduction of tissue nitric oxide ... |
2,321,829 | NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats. | Increased bioavailability of reactive oxygen species (ROS) has been implicated in the pathogenesis of mineralocorticoid hypertension. To find out the source of ROS, we evaluated the role of NAD(P)H oxidase in blood pressure (BP) elevation, cardiovascular hypertrophy, and fibrosis in aldosterone-salt rats. Aldosterone i... |
2,321,830 | Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus. | Intramyocardial injection of adeno-associated virus (AAV) has been shown to be an effective strategy for cardiac gene delivery. This approach leads to long-term gene expression in the heart, offering the possibility of chronic gene therapy. However, the long-term safety of this approach with regard to vector bio-distri... |
2,321,831 | Cell proliferation in the lamprey central nervous system. | After spinal cord transection, axons regenerate both in larval and adult lampreys. It is not known to what degree cells proliferate, even in the uninjured animal. Therefore, we have determined the prevalence of mitosis in the lamprey central nervous system (CNS). Bromodeoxyuridine (BrdU) was injected and incorporated f... |
2,321,832 | Hippocampal volume deficits in alcoholic Korsakoff's syndrome. | To examine whether the amnesic syndrome of alcoholic Korsakoff's syndrome (KS) originates from pathology of the hippocampus and not solely the diencephalon.</AbstractText>The authors studied 5 patients with KS and two comparison groups: 20 patients with Alzheimer's disease (AD) with known bilateral hippocampal volume l... |
2,321,833 | Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats. | In the brain, ouabain-like compounds (OLC) and the reninangiotensin system (RAS) contribute to sympathetic hyperactivity in rats after myocardial infarction (MI). This study aimed to evaluate changes in components of the central vs. the peripheral RAS. Angiotensin-converting enzyme (ACE) and angiotensin type 1 (AT1) re... |
2,321,834 | The effects of inhaled nitric oxide on cardiac pathology and energy metabolism in a canine model of smoke inhalation injury. | The effects of inhaled nitric oxide (NO) on cardiac pathology and energy metabolism were studied in a canine model of smoke inhalation injury.</AbstractText>Twenty-one dogs were randomly divided into three groups: four dogs constituted the normal control group (group N), eight dogs subjected to smoke inhalation followe... |
2,321,835 | Differences in cerebrospinal fluid dynamics do not affect the levels of biochemical markers in ventricular CSF from patients with aqueductal stenosis and idiopathic normal pressure hydrocephalus. | To compare levels of biochemical markers in ventricular cerebrospinal fluid (vCSF) between patients with aqueductal stenosis (AS) and idiopathic normal pressure hydrocephalus (INPH) and relate these results to clinical outcome after surgery. Neurofilament light protein, tau protein, sulfatide, vasoactive intestinal pep... |
2,321,836 | Pro-inflammatory cytokines modulate matrix metalloproteinase secretion and organic anion transport at the blood-cerebrospinal fluid barrier. | Neuroinflammation and neuroinfection trigger cytokine-mediated responses that include an increase in the cerebrospinal fluid (CSF) levels of pro-inflammatory matrix metalloproteinases (MMPs) and organic anions such as leukotrienes and prostaglandins. The choroid plexus (CP) epithelium forming the interface between the ... |
2,321,837 | Brain tumor presenting as anorexia nervosa in a 19-year-old man. | Slow-growing brain tumors can produce disturbances of food intake and endocrine dysfunction. We report a case of slow-growing midline brain tumor in a patient with clinical presentation of anorexia nervosa (AN). A 19-year-old man was referred from a general practitioner to a psychiatric clinic due to illness behavior a... |
2,321,838 | Neurokinin type-3 receptor stimulation impairs ethanol-associated appetitive behavior in Wistar rats. | Stimulating central neurokinin type-3 (NK-3) receptors decreases ethanol intake in rats. Although paraventricular nucleus of the hypothalamus (PVN) has a high density of NK-3 receptors, their influence on ethanol reinforcement has not been examined. This study's purpose was to assess the effects of intra-PVN infusion o... |
2,321,839 | Lobar holoprosencephaly in a Miniature Schnauzer with hypodipsic hypernatremia.<Pagination><StartPage>1783</StartPage><EndPage>1778</EndPage><MedlinePgn>1783-7, 1778</MedlinePgn></Pagination><Abstract><AbstractText>A 9-month-old male Miniature Schnauzer was examined because of a lifelong history of behavioral abnormali... | A 9-month-old male Miniature Schnauzer was examined because of a lifelong history of behavioral abnormalities, including hypodipsia. Diagnostic evaluation revealed marked hypernatremia and a single forebrain ventricle. The behavioral abnormalities did not resolve with correction of the hypernatremia, and the dog was eu... |
2,321,840 | Endoscopic aqueductoplasty: stent or not to stent? | The aim of this study is to evaluate if the long-term interventricular communication following aqueductoplasty is determined by the etiology of the aqueductal stenosis (AS).</AbstractText>We retrospectively analyzed 27 patients who underwent endoscopic aqueductoplasty or endoscopic interventriculostomy with or without ... |
2,321,841 | Subcellular distribution of protein kinase C isozymes during cardioplegic arrest. | On the basis of the hypothesis that cardioplegia-associated myocardial depression was due to activation of protein kinase C, we examined whether specific protein kinase C isozymes would translocate to a cellular fraction containing myofilaments.</AbstractText>Isolated rat hearts were perfused with Krebs-Ringer bicarbon... |
2,321,842 | Impaired systemic ventricular relaxation affects postoperative short-term outcome in Fontan patients. | Systemic ventricular end-diastolic pressure has been used as a predictor of outcome in patients undergoing the Fontan operation. However, this index only evaluates late diastolic function and does not assess active ventricular relaxation during the phase of early diastole, a key component of systemic venous pathway flo... |
2,321,843 | Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. | Previous studies have demonstrated that acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by injection leads to inhibition of caudal fin regeneration in zebrafish. Since the TCDD exposure in these studies is systemic, it is possible that pathology in organs other than the fin could result in inhibition of fi... |
2,321,844 | Popliteal artery bullet embolism in a case of homicide: a case report and review of the tangible literature. | Bullet embolism is a well known but a relatively rare phenomenon in common medicolegal autopsy practice. We present a homicide case of a bullet embolism to the left popliteal artery with interesting trajectory of projectile through the chest wall and right heart ventricle into the aortic lumen. Since in our presented c... |
2,321,845 | Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes. | Effects of the isoflavone protein tyrosine kinase (PTK) inhibitor genistein on voltage-dependent K(+) currents, i.e., transient outward K(+) current (I(to)), sustained K(+) current (I(ss)), and inward rectifier K(+) current (I(K1)) were studied in rat cardiac ventricular myocytes. It was found that I(to) was reversibly... |
2,321,846 | [Studies on the changes in expression of hypoxia induction factor-1alpha in myocardial tissue in severely scalded rats during early postburn stage]. | To investigate the changes in the expression of hypoxia induction factor-1alpha (HIF1-alpha) in myocardial tissues in severely scalded rats during early postburn stage.</AbstractText>Male Wistar rats inflicted with 40% TBSA III degree scald were employed as the model. The myocardial tissue samples were harvested from t... |
2,321,847 | Hypertensive brainstem encephalopathy. | A 45-year-old man developed severe arterial hypertension associated with unusual hyperintensity in the brainstem, around the right internal capsule and in the deep white matter around the bilateral anterior horn of the lateral ventricle on T2-weighted and fluid-attenuated inversion-recovery images. The characteristic c... |
2,321,848 | Fast interactive real-time volume rendering of real-time three-dimensional echocardiography: an implementation for low-end computers.<Pagination><StartPage>613</StartPage><EndPage>616</EndPage><MedlinePgn>613-6</MedlinePgn></Pagination><Abstract><AbstractText>Real-time three-dimensional echocardiography (RT3DE) is an i... | Real-time three-dimensional echocardiography (RT3DE) is an innovative cardiac imaging modality. However, partly due to lack of user-friendly software, RT3DE has not been widely accepted as a clinical tool. The object of this study was to develop and implement a fast and interactive volume renderer of RT3DE datasets des... |
2,321,849 | Clinical application of wave intensity for the treatment of essential hypertension. | Wave intensity analysis is a method of studying intravascular flow wave propagation, calculated as the product of the rate of change in pressure (d P/ t) and the rate of change in velocity (d U/d t). The typical pattern of wave intensity seen during the cardiac cycle has two dominant peaks. The larger first peak (FP) o... |
2,321,850 | [Long-term remnants of coagulation necrosis of cardiomyocytes following myocardial infarction]. | Remnants of cardiomyocytes showing coagulation necrosis in the scars caused by myocardial infarction were histopathologically studied. Among 305 autopsy cases of acute and/or healed myocardial infarction, 8 cases (7 men, 1 woman, ages 62 - 87 years, mean age 72.1) had masses of cardiomyocytes with coagulation necrosis ... |
2,321,851 | Generation of functional radial glial cells by embryonic and adult forebrain neural stem cells. | Radial glial cells (RGCs), a transient cell population present only in the developing CNS, function both as precursor cells and as scaffolds to support neuron migration. Their cellular origin, however, is not understood. In the present study, we tested the hypothesis that functional RGCs can be generated by multipotent... |
2,321,852 | Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. | To determine whether the type 2 iodothyronine deiodinase (D2), the principal central nervous system enzyme converting T(4) to biologically active T(3), is regulated in tanycytes by immune activation, D2 activity was measured in the mediobasal hypothalamus (MBH) 4, 12, and 24 h after administration of bacterial lipopoly... |
2,321,853 | Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression. | Monocyte chemoattractant protein 1 (MCP-1) could contribute to enhanced leukocyte recruitment and activation resulting in chronic tissue damage. However, little is known about the molecular mechanisms of cardiac MCP-1 expression. To elucidate these molecular mechanisms, angiotensin II-induced expression of MCP-1 was ex... |
2,321,854 | Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult. | Age is a risk factor for the development of many neurological disorders, including alcohol-related neurological disorders. A rodent model of Wernicke-Korsakoff Syndrome (WKS), acute pyrithiamine-induced thiamine deficiency (PTD), produces diencephalic damage and impairments of memory similar to what is seen in WKS pati... |
2,321,855 | Quantitative follow-up analysis by computed tomographic imaging in neonatal hydrocephalus. | We sought a simple and accurate method to monitor neonatal hydrocephalic infants using standard computed tomographic scans. Volume measurements were made by means of pixel counting using a personal computer and a drawing device, as a graphic tablet system, over computed tomographic scans of six infants with neonatal hy... |
2,321,856 | Continuous laryngoscopic vocal cord monitoring for vascular malformation surgery in the medulla oblongata: technical note. | Resection of lesions located in the medulla oblongata may result in significant morbidity. The most lethal complications are swallowing disturbances, which can lead to aspiration pneumonia. To prevent this problem, the lower cranial nerves can be mapped with recording needles placed in the posterior pharyngeal wall and... |
2,321,857 | Intraventricular solitary fibrous tumor: an unusual tumor with radiological, ultrastructural, and immunohistochemical evaluation: case report. | Intracranial solitary fibrous tumors have been described previously, but intraventricular solitary fibrous tumors are extremely rare. We present what is, to our knowledge, the first reported case of solitary fibrous tumor in the third ventricle.</AbstractText>A 63-year-old man presented with weakness of his lower extre... |
2,321,858 | Cyclic GMP protein kinase activity is reduced in thyroxine-induced hypertrophic cardiac myocytes. | 1. We tested the hypothesis that the cGMP-dependent protein kinase has major negative functional effects in cardiac myocytes and that the importance of this pathway is reduced in thyroxine (T4; 0.5 mg/kg per day for 16 days) hypertrophic myocytes. 2. Using isolated ventricular myocytes from control (n = 7) and T4-treat... |
2,321,859 | Visuospatial deficits in children 3-7 years old with shunted hydrocephalus. | To define non-verbal intelligence deficits in children 3-7 years of age following shunted hydrocephalus (HCP).</AbstractText>Prospective randomised single-blinded study. Thirty shunted HCP (study) and 30 cardiac (control) patients between the ages of 3 and 7 years were compared on eight non-verbal subtests of the Junio... |
2,321,860 | Effect of a novel thromboxane A2 inhibitor on right ventricular-arterial coupling in endotoxic shock. | We investigated the effects of a dual thromboxane (TX)A2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on right ventricular-arterial coupling in a porcine model of endotoxic shock. Thirty minutes before the onset of 0.5 mg/kg endotoxin infusion, six pigs (Endo group) received an infusion with a placebo solut... |
2,321,861 | Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. | Titin, the largest myofilament protein, serves as a template for sarcomere assembly and acts as a molecular spring to contribute to diastolic function. Titin is known to be extremely susceptible to calcium-dependent protease degradation in vitro. We hypothesized that titin degradation is an early event in doxorubicin-i... |
2,321,862 | Magnetization recovery for signal enhancement: a fast imaging DEFT-based technique. | This paper describes the development and application of a new fast MRI technique based on the DEFT principle. The sequence named MAgnetization RecoverY for Signal Enhancement (MARYSE) is composed of two completely symmetric gradient echoes separated by a 180 degrees refocusing pulse. The RF pulse scheme, 90 degrees x-1... |
2,321,863 | Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases. | Parkinson's disease is characterized by a progressive degeneration of the substantia nigra pars compacta dopamine neurons that innervate the striatum. Unlike current treatments for PD, GDNF administration could potentially slow or halt the continued degeneration of nigral dopaminergic neurons. GDNF does not cross the b... |
2,321,864 | Acute effects of vanadate oligomers on heart, kidney, and liver histology in the Lusitanian toadfish (Halobatrachus didactylus). | The contribution of vanadate oligomers to the acute histological effects of vanadium was analyzed in the heart, kidney, and liver of Halobatrachus didactylus (Schneider, 1801). A sublethal vanadium dose (5 mM, 1 mL/kg) in the form of metavanadate (containing ortho and metameric species) or in the form of decavanadate (... |
2,321,865 | Mediolateral compartmentalization of the cerebellum is determined on the "birth date" of Purkinje cells. | The adult cerebellum is functionally compartmentalized into clusters along the mediolateral axis (M-L clusters), and a variety of molecular makers are expressed in specific subsets of M-L clusters. These M-L clusters appear to be the basic structure in which cerebellar functions are performed, but the mechanisms by whi... |
2,321,866 | Nitric oxide synthesis inhibition increases proliferation of neural precursors isolated from the postnatal mouse subventricular zone. | The subventricular zone (SVZ) of rodents retains the capacity to generate new neurons throughout the entire life of the animal. Neural progenitors of the SVZ survive and proliferate in vitro in the presence of epidermal growth factor (EGF). Nitric oxide (NO) has been shown to participate in neural tissue formation duri... |
2,321,867 | [A case of ventriculitis with bacterial meningitis occurred during the treatment of liver abscess]. | A 47-case-year old male was admitted to our hospital because of high fever and general fatigue. He had no immune deficiency, and had no other disease in his past history. On admission, the white blood cell count and C-reacted protein were severely elevated (18,700/microliter, 27.7 mg/dl, respectively) and abdominal CT ... |
2,321,868 | Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats. | The aim of the present study was to test the effects of a topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), on vaginal blood flow and hemodynamics in rats. Laser Doppler flowmetry was used to measure blood flow changes following topical application of D... |
2,321,869 | The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature. | Most central neurocytomas follow a benign clinical course. However, more aggressive variants have been described requiring additional surgical resection, radiation, or chemotherapy. Chemotherapy has rarely been used as an adjuvant therapy for central neurocytomas.</AbstractText>We report a case of a 20-year-old girl wh... |
2,321,870 | Infratentorial intracranial pressure monitoring in neurosurgical intensive care unit. | Monitoring intracranial pressure (ICP) is an important element of neurosurgical critical care that is used primarily as an indicator of adequate cerebral perfusion. Such monitoring is usually done with intraparenchymal, subdural or intraventricular pressure sensor connected to a pressure transducer system. In the past,... |
2,321,871 | Efficacy and safety of cefotaxime in combination with metronidazole for empirical treatment of brain abscess in clinical practice: a retrospective study of 66 consecutive cases. | Sixty-six consecutive patients with brain abscesses referred to a department of neurosurgery during a 10-year period and treated with cefotaxime were studied retrospectively by means of a prospectively designed protocol whose main areas of emphasis were duration of antibiotic treatment, sterilization rate, clinical out... |
2,321,872 | Effect of collimator choice on quantitative assessment of cardiac iodine 123 MIBG uptake. | Quantitative accuracy in iodine 123 studies may be impaired by septal penetration. We evaluated the effect of collimator choice on estimation of the heart-to-mediastinum (H/M) ratio in cardiac I-123 metaiodobenzylguanidine (MIBG) imaging.</AbstractText>A low-energy high-resolution (LEHR) collimator, special LEHR (SLEHR... |
2,321,873 | Left ventricular mass in dippers and nondippers with newly diagnosed hypertension. | Hypertensive subjects can be subdivided into 2 groups, dippers and nondippers, according to the presence or the lack of a nocturnal fall of blood pressure of more than 10%. Several studies have investigated cardiac organ damage in the 2 groups with discordant results, but they included subjects with different onset, se... |
2,321,874 | Inhibition of the sarcoplasmic reticulum Ca2+ pump with thapsigargin to estimate the contribution of Na+-Ca2+ exchange to ventricular myocyte relaxation. | Relaxation in the mammalian ventricle is initiated by Ca2+ removal from the cytosol, which is performed by three main transport systems: sarcoplasmic reticulum Ca2+-ATPase (SR-A), Na+-Ca2+ exchanger (NCX) and the so-called slow mechanisms (sarcolemmal Ca2+-ATPase and mitochondrial Ca2+ uptake). To estimate the relative... |
2,321,875 | Degenerative changes and cell death in long-living homo- and heterotopic transplants from embryonic germ layers of rat neocortex. | Morphological study of allotransplants of rat embryonic neocortex 14-18 months after transplantation into the neocortex, lateral cerebral ventricle, and sciatic nerve of adult animals revealed death of nerve and glial cells in the delayed postoperation period independently on the site of transplantation. After heteroto... |
2,321,876 | Neurological deficit and disturbances in higher nervous activity during modeling of perinatal hypoxic-ischemic damage to the central nervous system in rat pups. | Seven-day-old Wistar rat pups were subjected to unilateral occlusion of the common cerebral artery and maintained in oxygen-low atmosphere. Neurological and behavioral changes were monitored for 12 weeks. The survival rate of treated animals was 90%. Body weight gain in these rats was lower than in the control. Neurolo... |
2,321,877 | Effect of central infusions of neuropeptide Y on GnRH/LH axis in ewes during the early anoestrous period. | Neuropeptide Y (NPY) is a putative mediator of many physiological processes in the central nervous system including reproductive functions. In this study we examined the effect of NPY on the GnRH/LH secretory activity in early anoestrous ewes. Crossbreed ewes one week (group 1w, n=7) and six weeks (group 6w, n=7) after... |
2,321,878 | Reduced hippocampal volume in alcohol and substance naïve Vietnam combat veterans with posttraumatic stress disorder. | This pilot study was undertaken to exclude the effects of alcohol and other substances on brain morphology in posttraumatic stress disorder.</AbstractText>Posttraumatic stress disorder and alcohol use are among the conditions associated with decreased hippocampal volume. The possible confounding contribution of alcohol... |
2,321,879 | Immobility from administration of the alpha1-adrenergic antagonist, terazosin, in the IVth ventricle in rats. | Brain alpha1-adrenoceptors have been shown to be essential for motor activity and movement in mice using intraventricular injection of alpha1-antagonists. To facilitate subsequent neuroanatomical mapping of these receptors, the present study was undertaken to replicate these effects in the rat. Rats were administered t... |
2,321,880 | Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitro. | We have studied the molecular identity of adult mouse SVZ cells in situ, and after isolation and expansion as neurospheres in vitro. The gene and protein expression patterns of the adult cells have been compared to that of the cells from the lateral ganglionic eminence (LGE), their putative embryonic counterparts. The ... |
2,321,881 | [Possibility of predicting the use of doxazosin in the treatment of arterial hypertension]. | Fifteen patients with arterial hypertension (AH) were examined. Their peripheral venous hemodynamics, central circulation, systolic and diastolic functions were studied and a course therapy with doxazosin (cardura, Pfizer, USA) was performed for 30 days. Cardura (doxazosin) was found to be the drug of choice for antihy... |
2,321,882 | [Manifestations of local fibrosis in the clinical picture of carcinoids of digestive organs]. | A complex of clinical, functional, and morphological studies was made in 20 patients aged 39 to 78 years who had histologically verified gastrointestinal carcinoids in the pre- and postoperative periods, by employing laboratory tests and instrumental techniques. Removed tumors were morphologically studied. Sixteen pati... |
2,321,883 | Traumatic acute subdural haematomas of the posterior fossa: clinicoradiological analysis of 24 patients. | We report 24 patients with a traumatic acute subdural haematoma of the posterior fossa managed between 1997 and 1999 at 8 Italian neurosurgical centres.</AbstractText>Each centre provided data about patients' clinico-radiological findings, management, and outcomes, which were retrospectively reviewed.</AbstractText>A p... |
2,321,884 | [A dead and calcified right ventricular hydatic cyst. The limits of imaging]. | Cardiac echinococcosis is rare and only represents around 0.5% of all hydatic locations. Right ventricular location is exceptional.</AbstractText>We report the case of a 72 year-old man having a chronic obstructive pulmonary disease. During an acute respiratory failure, cardiac ultrasonography showed a right ventricula... |
2,321,885 | p38 MAP kinase-mediated negative inotropic effect of HIV gp120 on cardiac myocytes. | Myocardial dysfunction leading to dilated cardiomyopathy has been documented with surprisingly high frequency in human immunodeficiency virus (HIV)-infected individuals. p38 MAP kinase has been implicated as a mediator of myocardial dysfunction. We previously reported p38 MAP kinase activation by the HIV coat protein g... |
2,321,886 | Sex and handedness differences in size of cerebral ventricles of normal subjects. | Sex and handedness differences in the volumes of cerebral ventricles were studied in 20 right- and 21 left-handed subjects. To assess the volumes of cerebral ventricles, Cavalieri's method was used using MRI. In right-handers, the volume of the lateral ventricle was higher in the right side than in the left side, but, ... |
2,321,887 | Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin. | The involvement of the satiety-controlling hormone leptin in the modulation of the reward-associated dopamine release was investigated by monitoring the extracellular dopamine concentration in microdialysates from the nucleus accumbens of rats during feeding after infusion of leptin or artificial cerebrospinal fluid in... |
2,321,888 | Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction. | To investigate the functional role of myosin light chain (MLC) isoforms in cardiac muscles, we examined the motor function of two different myosins the structure of which differed only in the MLC.</AbstractText>We purified myosin from atria (A-myosin) and ventricles (V-myosin) of young rats, which contained atrial-type... |
2,321,889 | Feline intracranial neoplasia: retrospective review of 160 cases (1985-2001). | The purpose of this study was to determine the frequency of different tumor types within a large cohort of cats with intracranial neoplasia and to attempt to correlate signalment, tumor size and location, and survival time for each tumor. Medical records of 160 cats with confirmed intracranial neoplasia evaluated betwe... |
2,321,890 | The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. | The proapoptotic Bcl-2 family members Bak and Bax play central and redundant roles in the regulation of apoptosis. In this study, we investigated the effect of loss of Bax and Bak in the CNS. The adult bax-/-bak-/- mice display masses of densely staining cells in the proliferative zones of the brain. These cells are sh... |
2,321,891 | Periventricular/intraventricular hemorrhage in neonatal mouse cerebrum. | Periventricular/intraventricular hemorrhage (PVH/IVH) into brain can occur in premature infants and is associated with poor developmental outcome. The purpose of this study was to develop and characterize a model of PVH/IVH in newborn mouse. We hypothesized that periventricular germinal matrix would exhibit reduced cel... |
2,321,892 | Altered corticogenesis and neuronal morphology in irradiation-induced cortical dysplasia: a Golgi-Cox study. | Cortical dysplasia has a strong clinical association with epilepsy and mental retardation, but the relationship between alterations in cortical structure and function in dysplasia-related disorders is poorly understood. The cerebral cortex of irradiated rats, an experimental model of cortical dysplasia, was studied usi... |
2,321,893 | [Neuroendoscopic treatment for Rathke's cleft cyst: transventricular approach to suprasellar cystic lesion]. | We report a case of a Rathke's cleft cyst, which was successfully treated by neuroendoscopy. The endoscopic procedure for the intra-suprasellar cystic lesion used the transventricular approach, similar to that of third ventriculostomy. A 66-year-old woman suffered from headache, nausea and constriction of the visual fi... |
2,321,894 | A magnetic resonance volumetric study of the temporal lobe structures in depression. | Depression is one of the most common psychiatric disorders and is associated with considerable morbidity. In recent years structural-imaging technology has provided an opportunity to examine the brain anatomy in patients with the psychiatric illness. 10 patients of various ages and, as the control group, 16 healthy sub... |
2,321,895 | Comparative sequences of canine and feline endothelin-1. | Endothelin-1 (ET-1, "mature ET-1") is a potent vasoconstrictor peptide that is made along with "big ET-1" from its precursor, preproET-1. Increased plasma concentrations of ET-1 and big ET-1 occur with various forms of cardiovascular disease in humans. Our laboratory is investigating plasma endothelins as diagnostic te... |
2,321,896 | Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. | We have found that neuregulin-1beta (NRG-1beta) is expressed in the cardiac microvascular endothelium, and promotes the growth and survival of cardiac myocytes in culture through the activation of erbB2 and erbB4 receptor tyrosine kinases. In this study, we examined the role of NRG-1/erbB signaling in protection of car... |
2,321,897 | Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes. | To study the effects of tumor necrosis factor-alpha (TNF-alpha) on calcium movement in rat ventricular myocytes.</AbstractText>Intracellular free Ca2+ concentration was measured with calcium fluorescent probe Fluo-3/AM and laser confocal microscope. L-type calcium current (ICa,L) was recorded with the whole-cell config... |
2,321,898 | Puerarin blocks Na+ current in rat ventricular myocytes. | To study the effect of puerarin (Pue) on Na+ channel in rat ventricular myocytes.</AbstractText>Whole-cell patch-clamp technique was applied on isolated cardiomyocytes from rats.</AbstractText>Pue inhibited cardiac INa in a positive rate-dependent and dose-dependent manner, with an IC(50) of 349 micromol/L. The kinetic... |
2,321,899 | Lectin binding in the choroid plexuses of the chick embryo. | In the present research we have studied the distribution and the changes of the oligosaccharidic component of the glycoconjugates during the development of the choroids plexuses of the 3rd ventricle and of the lateral ventricles in chick embryos and in 3-day-old chicken. For this purpose a battery of seven horseradish ... |
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