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2,322,200 | Growth and maturation of cardiac myocytes in fetal sheep in the second half of gestation. | Right (RVFW) and left (LVFW) ventricular free wall cardiac myocytes were collected from 25 fetal sheep aged 77-146 days gestation (term = 150 days gestation), six saline-infused catheterized fetal sheep (129 GD), and five lambs to measure gestational changes in uni- and binucleated cardiac myocyte numbers and cell volu... |
2,322,201 | Localization of functional endothelin receptor signaling complexes in cardiac transverse tubules. | Endothelin-1 (ET-1) is an autocrine factor in the mammalian heart important in enhancing cardiac performance, protecting against myocardial ischemia, and initiating the development of cardiac hypertrophy. The ETA receptor is a seven-transmembrane G-protein-coupled receptor whose precise subcellular localization in card... |
2,322,202 | Correlation between spontaneous feeding behavior and neuropeptide Y profile in the third ventricular cerebrospinal fluid of goats. | Feeding behavior is regulated by neural signals in the hypothalamus, but secretory activities of these signals in vivo and their relationship with spontaneous feeding remain to be solved. In the present study, we investigated the correlation between neuropeptide Y (NPY) and somatostatin (SRIF) profiles in cerebrospinal... |
2,322,203 | Cloning and characterization of zebrafish tbx1. | Tbx1 is one of the genes within the DiGeorge Critical Region (DGCR) and has been recently identified as the critical gene for the cardiovascular anomalies in the DiGeorge mouse models. We have cloned, sequenced and analyzed the zebrafish (Danio rerio) tbx1 cDNA. It encodes a protein of 460 amino acids that shares 64% i... |
2,322,204 | [Comparison of the intracranial pressure value in patients with hypertensive intracerebral hemorrhage treated with traditional craniotomy and puncture drainage]. | To compare the difference of intracranial pressure (ICP) in patients with hypertensive intracerebral hemorrhage (HICH) treated with two surgical procedures, traditional craniotomy and puncture drainage.</AbstractText>One hundred and twelve cases with HICH were randomly divided into two groups. In one group, 60 patients... |
2,322,205 | [An evaluation of surgical techniques and oncologic results in early glottic cancers]. | We evaluated the surgical techniques employed and survival rates in patients who were treated for early glottic cancer.</AbstractText>The study included 29 patients (28 males, 1 female; mean age 59 years; range 47 to 73 years) who underwent surgery for early glottic cancer. Surgical techniques were employed in view of ... |
2,322,206 | Type I collagen-induced MMP-2 activation coincides with up-regulation of membrane type 1-matrix metalloproteinase and TIMP-2 in cardiac fibroblasts. | Migration of cardiac fibroblasts is implicated in infarct healing and ventricular remodeling. Activation of matrix metalloproteinases induced by three-dimensional type I collagen, the principal component of the myocardial interstitium, is hypothesized to be essential for this migration. By utilizing primary cultures of... |
2,322,207 | Comparison of intracardiac cell transplantation: autologous skeletal myoblasts versus bone marrow cells. | Multiple cell types are being proposed for cardiac repair, but side-by-side comparisons are lacking. We tested the hypothesis that intracardiac transplantation of autologous bone marrow- or skeletal muscle-derived progenitor cells improve regional heart function to a similar degree.</AbstractText>Thirty-nine New Zealan... |
2,322,208 | Actions of amphetamine derivatives and cathinone at the noradrenaline transporter. | We have recently shown that methylenedioxymethamphetamine (MDMA), methylenedioxyamphetamine (MDA), cathinone and methylenedioxyethylamphetamine (MDEA) have a cocaine-like action to potentiate the contractile actions of noradrenaline but not isoprenaline in the 1-Hz paced rat right ventricle. The purpose of this study w... |
2,322,209 | Blood-mediated scavenging of cerebrospinal fluid glutamate. | The maintenance of brain extracellular glutamate (Glu) at levels below its excitotoxic threshold is performed by Glu transporters present on glia and neurons as well as on brain capillary endothelial cells which remove brain Glu into blood. The feasibility of accelerating the naturally occurring brain-to-blood Glu effl... |
2,322,210 | Effects of triiodothyronine pretreatment on beta-adrenergic responses in stunned cardiac myocytes. | To investigate whether triiodothyronine pretreatment enhanced beta-adrenergic responses in stunned myocardium and whether this acute effect of triiodothyronine was mediated through the cyclic adenosine 3',5'-monophosphate (AMP) system.</AbstractText>A prospective study.</AbstractText>University laboratory.</AbstractTex... |
2,322,211 | Differences in the function of three conserved E-boxes of the muscle creatine kinase gene in cultured myocytes and in transgenic mouse skeletal and cardiac muscle. | The 1256-base pair enhancer-promoter of the mouse muscle creatine kinase gene includes three CAnnTG E-boxes that are conserved among mammals and have flanking and middle sequences conforming to consensus muscle regulatory factor binding sites. This study seeks to determine whether these E-boxes are critical for muscle ... |
2,322,212 | Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. | Proline-rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that links G-protein-coupled receptors to activation of MAPK cascades and cellular growth. In smooth muscle and other cell types, PYK2 activation is dependent on either Ca(2+) or protein kinase C (PKC), and we have previously shown that endo... |
2,322,213 | Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes. | The Ca(2+)-independent, voltage-gated transient outward current (I(to)) displays a marked increase during development of cardiomyocytes. However, the molecular mechanism remained unclear. In rat adult ventricular myocytes, I(to) can be divided into a fast (I(to,f)) and a slow (I(to,s)) component by recovery process fro... |
2,322,214 | [Prognostic stratification of the patient with ischemic cardiopathy]. | The mean goal in the evaluation of a patient with coronary artery disease is the identification of patients at high risk to develop major cardiac events, including mortality. Ischemic patients can be stratified using non-invasive and invasive methods. Invasive procedures have some disadvantages, especially in follow-up... |
2,322,215 | Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. | In addition to glucose, monocarboxylates including lactate represent a major source of energy for the brain, especially during development. We studied the immunocytochemical expression of the monocarboxylate transporters MCT1 and MCT2 in the rat brain between embryonic day (E) 16 and postnatal day (P) 14. At E16-18, MC... |
2,322,216 | Skeletal muscle ventricle pressure-volume properties conform to dynamic and static conditioning. | Chronic changes in skeletal muscle ventricle (SMV) size and strength can directly affect performance and stability. These changes may depend on the conditioning protocol or implant system. Therefore the effects of conditioning protocols on SMV geometry and contractility must be identified for optimal SMV design and app... |
2,322,217 | Possible involvement of preoptic estrogen receptor beta positive cells in luteinizing hormone surge in the rat. | The anteroventral periventricular nucleus (AVPV) of the preoptic area has been implicated in the induction of spontaneous ovulation. In the AVPV, we found a striking sex difference in the distribution of estrogen receptor (ER) positive cells. In females, a significantly larger number of ER mRNA-positive cells were visu... |
2,322,218 | Contractile response of different segments of the latissimus dorsi muscle to chronic stimulation. | This study was planned to investigate if there is any difference in terms of the muscle force between the distal and proximal segments of the latissimus dorsi muscle.</AbstractText>An inplantable mock circulation system was placed around the latissimus dorsi muscle. The wrapping procedure around the implantable mock ci... |
2,322,219 | Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes. | The effects of the agonist enantiomer S(-)Bay K 8644 on gating charge of L-type Ca channels were studied in single ventricular myocytes. From a holding potential (Vh) of -40 mV, saturating (250 nm) S(-)Bay K shifted the half-distribution voltage of the activation charge (Q1) vs. V curve -7.5 +/- 0.8 mV, almost identica... |
2,322,220 | Time related changes in calcium handling in the isolated ischemic and reperfused rat heart. | The main aim of this study was to assess the kinetics of intracellular free calcium (Ca(2+)i) handling by isolated rat hearts rendered ischemic for 30 min followed by 30 min of reperfusion analyzing the upstroke and downslope of the Ca(2+)i transient. Changes in mechanical performance and degradation of membrane phosph... |
2,322,221 | Uptake-1 carrier downregulates in parallel with the beta-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: implications for cardiac neuroimaging in human cardiomyopathies. | Imaging techniques have demonstrated in various cardiomyopathies that an altered uptake of radiolabeled norepinephrine (NE) analogs may coexist with beta-adrenergic receptor downregulation, but the relationships between these 2 alterations and their mechanisms remain unclear. The aim of this study was to evaluate the h... |
2,322,222 | Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging. | Neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with Alzheimer's disease (AD), non-AD dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein E (APOE) genotype. Neuropsychological t... |
2,322,223 | Possible association between congenital cytomegalovirus infection and autistic disorder. | We encountered seven children with symptomatic congenital cytomegalovirus (CMV) infection from 1988 to 1995, of whom two (28.6%) developed typical autistic disorder. Case 1: A boy born at 38 weeks' gestation with a birth weight of 3164 g showed generalized petechiae, hepatosplenomegaly, and positive serum CMV-specific ... |
2,322,224 | Optimizing probucol administration to preserve left ventricular compliance after reperfusion injury in the heterotopic rat heart isograft. | We investigated the optimal method of administering probucol to attenuate reperfusion-induced diastolic abnormalities in the left ventricle of the heterotopically transplanted rat heart isograft.</AbstractText>We assigned Lewis rats (n = 84) to 7 transplant groups. We arrested 42 hearts using coronary perfusion with hy... |
2,322,225 | Directional cues for arcuate NPY projections are present in the adult brain. | Arcuate nucleus neuropeptide Y (NPY) neurons project within the hypothalamus and to several extrahypothalamic brain areas. Plasticity in the formation of arcuate NPY projections established postnatally may underlie the phenotypic characteristics of food intake and body weight. In this work we determined if directional ... |
2,322,226 | Angiotensin type 1 receptor immunoreactivity in the thoracic spinal cord. | The angiotensin II type 1 receptor (AT1R) in the central nervous system (CNS) plays a pivotal role in determining blood pressure. However, the relationship of the receptor to neurones in the spinal cord which are the final CNS contribution to sympathetic outflow is unknown. Here we first use RT-PCR to show that AT1A, A... |
2,322,227 | Brain morphological abnormality in schizophrenia is independent of country of origin. | The disorder schizophrenia has a worldwide prevalence of 1% and is generally associated with lateral cerebral ventricular enlargement. Whether there is a relationship between these two findings is unclear but has aetiological relevance.</AbstractText>Consecutively admitted Chinese patients (n = 19) with first episode o... |
2,322,228 | Immunohistochemical localization of Bis protein in the rat central nervous system. | We studied the distribution of Bis (Bcl-2 interacting death suppressor) protein in the adult rat brain and spinal cord using immunohistochemistry. Immunoreactivity was observed in specific neuronal populations in distinct nuclei. The most intensely labeled cells were associated with the motor system, including most cra... |
2,322,229 | Effect of cardiac glycosides on action potential characteristics and contractility in cat ventricular myocytes: role of calcium overload. | There is increasing evidence that cardiac glycosides act through mechanisms distinct from inhibition of the sodium pump but which may contribute to their cardiac actions. To more fully define differences between agents indicative of multiple sites of action, we studied changes in contractility and action potential (AP)... |
2,322,230 | Epidermoid of the lateral ventricle: evaluation with diffusion-weighted and diffusion tensor imaging. | We report of a large epidermoid tumor of the lateral ventricle in a 67-year-old man. Conventional imaging (CT, T1/T2, MRI) could not differentiate the tumor from the surrounding cerebral spinal fluid (CSF). On diffusion-weighted and diffusion anisotropy images the tumor was clearly seen as a hyperintense mass surrounde... |
2,322,231 | Hydrocephalus therapy: reduction of shunt occlusions using a peel-away sheath. | In order to avoid shunt occlusions through particles of brain parenchyma a new procedure was used. Conventionally during ventricle puncture brain tissue may intrude into perforating holes of the ventricular catheter and subsequently shunt dysfunction may occur. By using a peel-away sheath the ventricular catheter can b... |
2,322,232 | Profiles of methotrexate in blood and CSF following intranasal and intravenous administration to rats.<Pagination><StartPage>1</StartPage><EndPage>7</EndPage><MedlinePgn>1-7</MedlinePgn></Pagination><Abstract><AbstractText>The aim of this paper was to investigate the levels of methotrexate (MTX) in blood and the cerebr... | The aim of this paper was to investigate the levels of methotrexate (MTX) in blood and the cerebrospinal fluid (CSF) in rats to find out whether there is any direct drug transport from nasal cavity to CSF following intranasal administration. Methotrexate was administered to male Sprague-Dawley rats either intranasally ... |
2,322,233 | In vivo tracking of neural progenitor cell migration to glioblastomas. | The ability to noninvasively track the migration, engraftment, and proliferation of neural progenitor cells (NPCs) has significant clinical and research implications. The purpose of our study was to explore the macroscopic migratory capabilities of NPCs toward brain tumors after implantation into nude mice. We stably t... |
2,322,234 | [Intramyocardial dissecting haematoma: an unusual form of cardiac rupture]. | The intramyocardial dissecting haematoma is an unusual rupture of the left ventricular wall, complicating acute myocardial infarction. The mechanism is an hemorrhagic dissection among the spiral myocardial fibres creating a neocavitation limited by the myocardium. It appears in 9% of left ventricular wall ruptures, com... |
2,322,235 | Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. | The interaction between translocated calcium/calmdulin-dependent protein kinase IIalpha (CaMK IIalpha) and SynGAP during brain ischemia was investigated by Western blotting and immunoprecipitation. Brain ischemia was induced by the four-vessel occlusion method on Sprague-Dawley rats. After 3 min global ischemia, both t... |
2,322,236 | Computational model of the ventricular action potential in adult spontaneously hypertensive rats. | Cardiac hypertrophy has substantial clinical significance because many hypertrophic cells have markedly prolonged repolarization behavior, which may lead to increased risk for cardiac arrhythmias. Spontaneously hypertensive rat (SHR) is one model of hypertension that is studied extensively and is considered to be the b... |
2,322,237 | Diffusion-weighted imaging predicts postoperative persistence in meningioma patients with peritumoural abnormalities on magnetic resonance imaging. | While diffusion-weighted magnetic resonance imaging (MRI) has been used to study malignant brain tumours, this modality has not been used to study MRI abnormalities surrounding meningiomas.</AbstractText>We examined intensity and apparent diffusion coefficient (ADC) on diffusion weighted imaging (DWI) for predicting po... |
2,322,238 | Beat-to-beat modulation of right and left ventricular positive dP/dt by afterload. Implications for the evaluation of inotropy. | The rate of pressure rise (dP/dtmax) has mainly been studied in the left ventricle (LV), where it was demonstrated to be highly dependent of preload, but independent of afterload. Load dependence of right ventricular (RV) dP/dtmax is assumed to be similar to (LV)dP/dtmax, although this issue has not yet been investigat... |
2,322,239 | [A study of the reconstructed vocal cords in dogs by electron microscopy]. | To make an assessment of the reconstruction of dog's vocal cord after cordectomy in experimental study.</AbstractText>The unilateral vocal cord, laryngeal ventricle, partial anteroinferior portion of ventricular band and the homolateral inner perichondrium of the thyroid cartilage were excised. The upper and lower neig... |
2,322,240 | Induction of connective tissue growth factor by angiotensin II: integration of signaling pathways. | Angiotensin II is recognized as one of the major mediators of cardiovascular pathology. Because connective tissue growth factor (CTGF) is involved in the pathophysiologic processes underlying fibrotic diseases, its regulation by angiotensin II was investigated.</AbstractText>In the 2-kidney, 1-clip model of renovascula... |
2,322,241 | Continuous administration of antisense oligonucleotides to c-fos reduced the development of seizure susceptibility after ethacrynic acid-induced seizure in mice. | We previously demonstrated that seizure susceptibility developed by the 14th day post-ethacrynic acid (EA)-induced seizure in mice, with a prolonged increase in the expression of c-fos mRNA in the brain during days 10-14. To examine whether such c-fos increase contributes to the development of seizure susceptibility, w... |
2,322,242 | Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. | To clarify the functional roles of ghrelin in regulating energy balance, we investigated the effects of a central infusion of ghrelin on food intake and the activity of the sympathetic nerve innervating brown adipose tissue (BAT), the site regulating energy expenditure in rodents. A bolus infusion of ghrelin at a dose ... |
2,322,243 | Towards ultrasound cardiac image segmentation based on the radiofrequency signal. | In echocardiography, the radio-frequency (RF) image is a rich source of information about the investigated tissues. Nevertheless, very few works are dedicated to boundary detection based on the RF image, as opposed to envelope image. In this paper, we investigate the feasibility and limitations of boundary detection in... |
2,322,244 | Statistical shape analysis of neuroanatomical structures based on medial models. | Knowledge about the biological variability of anatomical objects is essential for statistical shape analysis and discrimination between healthy and pathological structures. This paper describes a novel approach that incorporates the variability of an object population into the generation of a characteristic 3D shape mo... |
2,322,245 | Efficient simulation of three-dimensional anisotropic cardiac tissue using an adaptive mesh refinement method. | A recently developed space-time adaptive mesh refinement algorithm (AMRA) for simulating isotropic one- and two-dimensional excitable media is generalized to simulate three-dimensional anisotropic media. The accuracy and efficiency of the algorithm is investigated for anisotropic and inhomogeneous 2D and 3D domains usi... |
2,322,246 | Neural stem cells: a potential source for remyelination in neuroinflammatory disease. | In multiple sclerosis, the central nervous system is lesioned through invasion of plaque-forming inflammatory cells, primarily contributing to immune attack of myelin and oligodendrocytes. In this report we address the possible activation and differentiation of central nervous system stem cells following such immunolog... |
2,322,247 | Dynamic model of the left ventricle for use in simulation of myocardial perfusion SPECT and gated SPECT. | Simulation is a useful tool in cardiac SPECT to assess quantification algorithms. However, simple equation-based models are limited in their ability to simulate realistic heart motion and perfusion. We present a numerical dynamic model of the left ventricle, which allows us to simulate normal and anomalous cardiac cycl... |
2,322,248 | Stimulation of single isolated adult ventricular myocytes within a low volume using a planar microelectrode array. | Microchannels (40- microm wide, 10- microm high, 10-mm long, 70- microm pitch) were patterned in the silicone elastomer, polydimethylsiloxane on a microscope coverslip base. Integrated within each microchamber were individually addressable stimulation electrodes (40- microm wide, 20- microm long, 100-nm thick) and a co... |
2,322,249 | The possible roles of mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 2 in cardiac fibrosis in the spontaneously hypertensive rat. | In hypertension, aldosterone has been demonstrated to play a crucial role in cardiac fibrosis, which generally increases cardiac morbidity and death. However, few studies have reported the expression of the mineralocorticoid receptor (MR) and 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in the heart under h... |
2,322,250 | ATP and LPL histochemical activity of rat cardiomyocytes and adipocytes treated with androgenic anabolic steroids. | To study the effect of short-term and long-term treatment with retabolil, an androgenic anabolic steroid, on the activity of the enzymes ATP and LPL in rat cardiomyocytes and adipocytes.</AbstractText>Six male Wistar rats (mean weight 195-200 g.) were given retabolil 50 mg/kg once subcutaneously, another six were treat... |
2,322,251 | [Echocardiographic characteristics of the left heart ventricle in people with different somatotypes]. | The objective of this study was to analyze echocardiographic parameters in 143 healthy individuals aged 18-21 years with different somatotypes. The evaluation of somatotype was performed using the the method of R.N. Dorokhov and V.G. Petrukhin (1989). During the echocardiography, left ventricular wall thickness, intern... |
2,322,252 | [Development of human brain neural/progenitor cells after transplantation into the brain of adult rats]. | The purpose of the present study was the investigation of human neural stem/progenitor cells (SPC) cultured in vitro, with special reference to their capacity for grafting, migration and differentiation after transplantation into adult rat brain. SPC were isolated from the brain of 9-week-old human embryos and were cul... |
2,322,253 | [Criteria of functional operability and indications for intraoperative volumetric monitoring of patients during extensive surgical procedures on the lung]. | The investigation included 32 patients after extensive operative interventions on the lungs: pneumonectomy with circular resection of the trachea bifurcation and different kinds of combined pneumonectomies. Methods of Doppler echocardiography and thermal dilution were used for studying the parameters of lesser circulat... |
2,322,254 | C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis. | The proto-oncogene, c-src, has been implicated in the tumorigenesis in breast cancer. However, the relationship of c-src with distant metastasis is unclear. Moreover, the role of c-src in organ-preferential metastasis of breast cancer is unknown. Because breast cancer has a strong predilection for metastasizing to bone... |
2,322,255 | Hyperphagic effects of brainstem ghrelin administration. | The role of ghrelin in feeding control has been addressed from a largely hypothalamic perspective, with little attention directed at ingestive consequences of stimulation of the peptide's receptor, the growth hormone secretagogue receptor (GHS-R), in the caudal brainstem. Here, we demonstrate a hyperphagic response to ... |
2,322,256 | Subcellular distributions of calcitonin gene-related peptide (CGRP)-like immunoreactivity in the subcommissural organ of the golden hamster (Mesocricetus auratus). | Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as ros... |
2,322,257 | Increased susceptibility to ventricular arrhythmias in hypertensive paraplegic rats. | Individuals with spinal cord injury (SCI) between thoracic vertebrae four (T4) and five (T5) have elevated levels of sympathetic activity to the heart. Notably, female spontaneously hypertensive rats (SHR) also have increased cardiac sympathetic nerve activity (SNA). Since elevated levels of cardiac SNA increase the ri... |
2,322,258 | Chronic endopeptidase inhibition in DOCA-salt hypertension: mechanism of cardiovascular protection. | These studies examined the interactions of neutral endopeptidase (NEP), endothelin-1 (ET-1), and nitric oxide (NO) in deoxycorticosterone acetate (DOCA)-induced hypertension. Male Sprague-Dawley rats (n = 35) were uninephrectomized (UNx) or uninephrectomized and treated with DOCA (25 mg pellet implanted subcutaneously)... |
2,322,259 | [Usefulness of transesophageal echocardiography in monitoring pulmonary artery catheter progression in a case of tricuspid annuloplasty].<Pagination><StartPage>303</StartPage><EndPage>306</EndPage><MedlinePgn>303-6</MedlinePgn></Pagination><Abstract><AbstractText>A 47-year-old man with mitral and aortic valve prosthese... | A 47-year-old man with mitral and aortic valve prostheses and a tricuspid valve annuloplasty required emergency substitution of both valves because of infectious endocarditis on the aortic valve prosthesis. The tricuspid ring initially impeded insertion of the pulmonary artery catheter toward the right ventricle. With ... |
2,322,260 | Low levels of ventricular CSF orexin/hypocretin in advanced PD. | The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compa... |
2,322,261 | Widening spectrum of congenital hemiplegia: Periventricular venous infarction in term neonates. | MRI in five term children with congenital hemiplegia without clinically apparent prenatal or perinatal difficulties showed a focal or porencephalic enlargement of the lateral ventricle and periventricular T2 prolongation, which were identical to findings of periventricular venous infarction seen in preterm children. So... |
2,322,262 | Changes in premorbid brain volume predict Alzheimer's disease pathology. | To assess whether changes in antemortem MRI brain volume measurements are valid predictors of subsequent Alzheimer disease (AD) pathology.</AbstractText>Thirty-nine subjects, 15 nondemented and 24 with cognitive impairment, were followed until death. Regional postmortem measures of senile plaque (SP) and neurofibrillar... |
2,322,263 | Coxsackie B1 infection associated with ventriculitis.<Pagination><StartPage>750</StartPage><EndPage>751</EndPage><MedlinePgn>750-1</MedlinePgn></Pagination><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Erickson</LastName><ForeName>Lia Simpson</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Dep... | The review addresses an analysis of the causes of neurodegenerative process development in multiple sclerosis (MS) as well as the modern approaches to the treatment of the disease. The best-studied mechanisms of degenerative alterations and clinical and experimental evidence supported the protective influence of beta-i... |
2,322,264 | Inflow effect in first-pass cardiac and renal MRI. | To estimate the effect of the inflow effect on the arterial input function in vivo in cardiac and renal MR perfusion imaging using fast gradient echo (GRE) sequences and contrast media.</AbstractText>The MR exam protocol was designed to acquire images at different phases of the cardiac cycle. The arterial input was thu... |
2,322,265 | Aqueductal stenosis 9 years after mumps meningoencephalitis: treatment by endoscopic third ventriculostomy. | Hydrocephalus due to aqueductal stenosis following mumps meningoencephalitis is a rare condition, reported only in 16 cases in the literature. The pathogenetic role of the mumps virus in inducing aqueductal stenosis has been demonstrated experimentally in animal models and clinically proven in a few cases. Although obs... |
2,322,266 | Evolution of forebrain and spatial cognition in vertebrates: conservation across diversity. | Historically the dominant trend in comparative brain and behavior research has emphasized the differences in cognition and its neural basis among species. In fact, the vertebrate forebrain shows a remarkable range of diversity and specialized adaptations. Probably the major morphological variation is that observed in t... |
2,322,267 | Long-term restitution of 4-aminopyridine-sensitive currents in Kv1DN ventricular myocytes using adeno-associated virus-mediated delivery of Kv1.5. | Overexpression of a dominant-negative truncated Kv1.1 (Kv1DN) polypeptide in the mouse heart resulted in marked attenuation of a 4-aminopyridine (4-AP)-sensitive current, I(K,slow1). We used recombinant adeno-associated virus (rAAV) as a vector for direct delivery of Kv1.5 into the mouse myocardium in order to normaliz... |
2,322,268 | Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes. | The expression of cyclooxygenase-2 (COX-2) is a characteristic response to inflammation, which can be inhibited with sodium salicylate. IL-1beta and TNF-alpha can induce extracellular signal-regulated kinase (ERK), IKK, IkappaB degradation and NF-kappaB activation. Salicylate inhibited the IL-1beta and TNF-alpha-induce... |
2,322,269 | [Choroid plexus carcinoma of the foramen Luschka: a case report]. | Choroid plexus carcinoma(CPC) is a rare intracranial neoplasm that usually arises in the supra-tentorial region of infants. We report an adult case of CPC that arose in the foramen Luschka. A 61-year-old woman presented with a 10-year history of dysarthria. CT showed an iso- to slightly high density mass in the left fo... |
2,322,270 | Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice. | The population dynamics of Borrelia burgdorferi were quantified by real-time PCR targeting the flaB gene in skin (inoculation site, noninoculation site, and ear), heart (heart base and ventricle), quadriceps muscle, and the tibiotarsal joint at 1, 2, 4, 6, and 8 weeks after intradermal inoculation in C3H and C3H-scid m... |
2,322,271 | Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. | The peroxisome proliferator activated receptors (PPARs) appear to have beneficial effects in the cardiovascular system. PPAR gamma has been shown previously to exert an inhibitory effect on cardiac myocyte hypertrophy in vivo and in vitro. Using endothelin to activate the hypertrophic program in neonatal rat cardiac my... |
2,322,272 | Intracerebroventricular galanin-like peptide induces different brain activation compared with galanin. | Like galanin, the 60-amino-acid peptide, galanin-like peptide (GALP), has orexigenic actions, demonstrated by an acute increase in feeding after central injection in rodents. However, in contrast to galanin, GALP causes a prolonged rise in core body temperature and a reduction in body weight over 24 h. In an attempt to... |
2,322,273 | Gender differences in myosin heavy chain-beta and phosphorylated phospholamban in diabetic rat hearts. | The objective of this study was to determine whether a gender difference exists in myosin heavy chain (MHC) isoform or sarcoplasmic reticulum protein levels in diabetic rat hearts. As is the case with normal rodent hearts, all four chambers of the control rat hearts expressed almost 100% MHC-alpha. In 6-wk diabetic rat... |
2,322,274 | Effects of Na+/Ca2+ exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytes. | In cardiac cells, evoked Ca2+ releases or spontaneous Ca2+ waves activate the inward Na+/Ca2+ exchange current (INaCa), which may modulate membrane excitability and arrhythmogenesis. In this study, we examined changes in membrane potential due to INaCa elicited by sarcoplasmic reticulum (SR) Ca2+ release in guinea pig ... |
2,322,275 | Excitatory effects of motilin in the hippocampus on gastric motility in rats. | Intestinal motilin is known to stimulate gastrointestinal motility. Recently, it was shown that the motilin gene and the motilin receptor are expressed in various regions of the brain. We studied whether motilin can activate pathways in the rat hippocampus to stimulate gastric motility. Gastric motility was monitored i... |
2,322,276 | Growth hormone induces myocardial expression of creatine transporter and decreases plasma levels of IL-1beta in rats during early postinfarct cardiac remodeling. | Growth hormone has been proposed as a potential new therapeutic agent for treatment of myocardial infarction (MI) and congestive heart failure (CHF). The purpose of this study was to evaluate the effects of GH on: (a) myocardial expression of creatine transporter (CreaT) during early postinfarct remodeling, (b) myocard... |
2,322,277 | Survival after stenting of severe atherosclerotic ostial renal artery stenoses. | To examine long-term survival after angioplasty and stenting of atherosclerotic renal artery stenosis (RAS).</AbstractText>Over a 5-year period, 241 consecutive patients (153 men; mean age 67+/-9 years, range 44-84) were treated with angioplasty and stent implantation for 355 ostial renal stenoses >70%. The procedur... |
2,322,278 | [Ventricular activation time maps in health and after myocardial infarction registered in spherical system]. | The present paper concerns the results of the examinations on Ventricular Activation Time distribution. The registrations were performed using the 30-electrode network connected to from the diamentoid scheme giving the sphere system, in the centre of which the heart is located. The potentials for one ECG cycle were mea... |
2,322,279 | [Rare case of a malignant brain neoplasm in an 18-years old pregnant woman]. | Authors presented rare case of anaplastic ependymoma diagnosed in the first trimester of pregnancy 18-years of age patient. Main symptoms of increased intracranial pressure and cerebral edema were vomits, severe headache and apathy. In the sixteen week of pregnancy performed craniotomy and evacuated malignant tumor of ... |
2,322,280 | Low-voltage triggering of Ca2+ release from the sarcoplasmic reticulum in cardiac muscle cells. | This study investigated the interaction between L-type Ca2+ current (ICaL) and Ca2+ release from the sarcoplasmic reticulum (SRCR) in whole cell voltage-clamped guinea pig ventricular myocytes. Quasiphysiological cation solutions (Nao+:KI+) were used for most experiments. In control conditions, there was no obvious int... |
2,322,281 | Relationships between cholinergic phenotype and acetyl-CoA level in hybrid murine neuroblastoma cells of septal origin. | High susceptibility of cholinergic neurons to neurotoxic signals may result from their utilization of acetyl-CoA for both energy production and acetylcholine synthesis. SN56 cholinergic cells were transfected stably with cDNA for choline acetyltransferase. Transfected cells (SN56ChAT2) expressed choline acetyltransfera... |
2,322,282 | Computer reconstruction of the three-dimensional structure of mouse cerebral ventricles. | In the brain, the cerebral ventricles are important as the site of cerebrospinal fluid production. The cerebral ventricles consist of the lateral ventricles, the third ventricle and the fourth ventricle, and their stereoscopic structures and the connections between them are not visible from outside of the brain. Observ... |
2,322,283 | Effects of mercury on myosin ATPase in the ventricular myocardium of the rat. | Mercury reduces twitch and tetanic force development in isolated rat papillary muscles, and a putative toxic effect on the contractile machinery has been suggested. Based on that, the actions of HgCl2 on the myosin ATPase activity of the left ventricular myocardium were investigated. Samples for assay of myosin ATPase ... |
2,322,284 | Anatomical markers for the subdivisions of the barn owl's inferior-collicular complex and adjacent peri- and subventricular structures. | The anatomy of the inferior-collicular complex of the barn owl, situated below the fourth ventricle in the tectal lobe, was studied by determining the distribution of antigens with antibodies directed against tyrosine hydroxylase, gamma-aminobutyric acid (GABA)(Abeta), dopamine- and cyclic AMP-regulated phosphoprotein ... |
2,322,285 | Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. | One line of mice harboring a cardiac-specific epoxygenase transgene developed head swelling and rapid neurological decline in young adulthood, and had marked hydrocephalus of the lateral and third ventricles. The transgene was found to be inserted into an intron in the mouse Rfx4 locus. This insertion apparently preven... |
2,322,286 | Complexity of inducible nitric oxide synthase: cellular source determines benefit versus toxicity. | Inducible nitric oxide synthase (iNOS) has been shown to have both beneficial and detrimental effects in sepsis. We focused on a single organ, the heart, and used 2 distinct cell types that express iNOS-the cardiac myocyte and the infiltrating neutrophil-to study the distinct functional effects of iNOS derived from het... |
2,322,287 | Association of learning and memory impairments with changes in the septohippocampal cholinergic system in rats with kaolin-induced hydrocephalus. | The septohippocampal cholinergic (SHC) system plays an important role in the maintenance of normal memory and learning. However, the fact that memory and learning impairments under hydrocephalic conditions are directly related to the SHC system is less well known. We investigated the relationships between pathological ... |
2,322,288 | Death after late failure of endoscopic third ventriculostomy: a potential solution. | Late failure after successful third ventriculostomy is rare, and death caused by failure of a previously successful third ventriculostomy has been reported on four occasions. We describe a simple innovation that adds little morbidity and has the potential to reduce the advent of death after late failure of endoscopic t... |
2,322,289 | An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. | Interdependence between estradiol and insulin-like growth factor-I has been documented for different neural events, including neuronal differentiation, synaptic plasticity, neuroendocrine regulation and neuroprotection. In the present study we have assessed whether both factors interact in the regulation of neurogenesi... |
2,322,290 | Computational and experimental study of proximal flow in ventricular catheters. Technical note. | The treatment of hydrocephalus with shunt insertion is fraught with high failure rates. Evidence indicates that the proximal holes in a catheter are the primary sites of blockage. The authors have studied ventricular catheter designs by using computational fluid dynamics (CFD), two-dimensional water table experiments, ... |
2,322,291 | Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis. Case report and review of the literature. | A 26-year-old woman with obstructive hydrocephalus caused by a cysticercal cyst blocking the left foramen of Monro was initially treated with an external ventriculostomy and subsequent endoscopically assisted cyst resection and septostomy. Postoperatively, the patient developed the clinical syndrome of akinetic mutism,... |
2,322,292 | Surgical experience in 130 pediatric patients with Chiari I malformations. | The aim of this study was to present the long-term findings of a surgical series of pediatric patients with Chiari I malformations.</AbstractText>One hundred thirty symptomatic pediatric patients with Chiari I malformations underwent posterior fossa decompression. The age in this group of patients ranged from 2 months ... |
2,322,293 | Intraventricular rupture of Nocardia brain abscess--case report. | A 71-year-old male presented with left hemiparesis and confused conversation. Computed tomography showed a mass lesion with rim enhancement in the right parietal lobe. He developed meningeal irritation the day after admission. Emergent fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) imaging revealed... |
2,322,294 | Three-dimensional reconstruction of a rhesus monkey brain from the Friedrich Sanides collection. | For this study, serial sections of a rhesus monkey brain prepared by Friedrich Sanides (1914-1984) were used to examine the architectonic parcellation of the cerebral cortex. The sections through the anterior part of a rhesus monkey brain (250 sections stained for myeloarchitecture and 250 sections stained for cytoarch... |
2,322,295 | Familial optic atrophy with white matter changes. | We report two brothers who suffer from infantile onset optic atrophy and blindness. MRI of the brain demonstrated periventricular white matter changes in both children. Neurological and developmental examination are normal. Extensive laboratory investigations rule out metabolic disorders that can be associated with opt... |
2,322,296 | Ketamine inhibits endotoxin-induced inositol 1,4,5-triphosphate in rat ventricular cardiomyocytes. | To investigate the effect of ketamine on endotoxin modulation of inositol 1,4,5-triphosphate (IP3) formation in cardiomyocytes.</AbstractText>A prospective observational cell culture study.</AbstractText>A research laboratory in the University of Hirosaki School of Medicine.</AbstractText>Neonatal rat cardiomyocytes.</... |
2,322,297 | Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. | The hindbrain roof plate and choroid plexus are essential organizing centers for inducing dorsal neuron fates and sustaining neuron function. To map the formation of these structures, we developed a broadly applicable, high resolution, recombinase-based method for mapping the fate of cells originating from coordinates ... |
2,322,298 | Temperature dependence of Na+-H+ exchange, Na+-HCO3- co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes. | Almost all aspects of cardiac function are sensitive to modest changes of temperature. We have examined the thermal sensitivity of intracellular pH regulation in the heart. To do this we determined the temperature sensitivity of pHi, intracellular buffering capacity, and the activity of sarcolemmal acid-extrusion prote... |
2,322,299 | Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs. | 1. The stimulatory effect of neuropeptide Y (NPY) on food intake is well established but the roles of the receptor subtypes Y(1) and Y(5) have been difficult to define. We have studied the effects of two novel Y(1)-preferring and two Y(5)-preferring agonists on feeding in guinea pigs. 2. The Y(1)-preferring receptor ag... |
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