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2,323,200 | Estradiol supplementation helps overcome central leptin resistance of ovariectomized mice on a high fat diet. | Ovariectomized mice on a high fat diet represent a model of diet-induced obesity during estrogen deficiency. Here, we tested the hypothesis that sensitivity to centrally administered leptin in ovariectomized mice with diet-induced obesity could be restored by estrogen supplementation. Ovariectomized C57BL/6 female mice... |
2,323,201 | [Citrobacter koseri brain abscess in an infant: case report and literature review]. | We present a 2 month-old female infant admitted to the hospital with macrocephaly as main clinical sign, irritability, and vomiting. The computer tomography scanning showed a cystic frontal image with contralateral ventricle displacement. Surgical intervention was performed. Purulent material culture was positive for C... |
2,323,202 | [Optic nerve hypoplasia and septo-optic dysplasia]. | The septo-optic dysplasia or De Morsier syndrome is an unusual disorder of the embryonic development. It consists of hypoplasia in one or both optic nerves, midline cerebral malformations and hypothalamic-pituitary dysfunction, which is inconstant. The present work describes the findings of 9 patients with septo-optic ... |
2,323,203 | Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. | Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia and mood disorders. Recent studies have shown that DISC1 has important functions in both brain development and adult brain function. We have described earlier a transgen... |
2,323,204 | The first report of fetal alcohol effect in a 12 year-old child in Korea. | We present the first report of fetal alcohol effect in a 12 year-old child in Korea. The mother had consumed 162 g of alcohol per week continuously during pregnancy. His first febrile seizure occurred before he was 1 year old, and became more frequent 2 years later. He started showing signs of right paraplegia when he ... |
2,323,205 | Cryptococcosis in organ transplantation. | Opportunistic infection is one of the important cause of graft dysfunction after organ transplantation. It usually occurs one year after post transplantation in a immunocompromised transplant recipient. Among the opportunistic infections fungal infection is important cause of graft dysfunction as well as increase morbi... |
2,323,206 | Prenatal diagnosis of monosomy 17p (17p13.3-->pter) associated with polyhydramnios, intrauterine growth restriction, ventriculomegaly, and Miller-Dieker lissencephaly syndrome in a fetus. | To present the prenatal magnetic resonance imaging (MRI) and ultrasound findings of Miller-Dieker lissencephaly syndrome (MDLS) associated with chromosome 17p13.3 deletion in a fetus.</AbstractText>A 30-year-old, primigravid woman was referred to the hospital at 31 weeks' gestation because of intrauterine growth restri... |
2,323,207 | De-routing neuronal precursors in the adult brain to sites of injury: role of the vasculature. | Neurogenesis in the adult brain occurs predominantly in the two regions, the subventricular zone (SVZ) bordering the lateral ventricle and subgranular zone (SGZ) of the hippocampus. The neuronal precursors are produced in the specialized microenvironment called neurovasculature niche. Recent evidences indicate that in ... |
2,323,208 | Short term treatment with estradiol decreases the rate of newly generated cells in the subventricular zone and main olfactory bulb of adult female mice. | Adult neurogenesis occurs most notably in the subgranular zone (SGZ) of the hippocampal dentate gyrus and in the olfactory bulb (OB) where new neurons are generated from neural progenitors cells produced in the subventricular zone (SVZ) of the forebrain. As it is well known that gonadal steroid hormones, primarily estr... |
2,323,209 | Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma. | To update our institutional experience with neoadjuvant chemotherapy and minimized radiotherapy vs. radiation monotherapy for intracranial germinoma.</AbstractText>We retrospectively reviewed records of 59 patients with diagnosis of primary intracranial germinoma between 1977 and 2007. Treatment was irradiation alone o... |
2,323,210 | Central ghrelin inhibits reflex swallowing elicited by activation of the superior laryngeal nerve in the rat. | The effect of ghrelin on rhythmic reflex swallowing was examined in urethane-chloralose anesthetized rats. Swallowing was monitored by recording electromyographic activities of the suprahyoid muscle. Fourth ventricular administration of ghrelin decreased swallowing frequency during electrical stimulation of the central... |
2,323,211 | A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes. | Using deconvolved confocal microscopy of fluorescently labeled markers for z-disks, t-tubules and ryanodine receptors, we have examined sarcomere organization in cardiac myocytes from rat, rabbit and human. We show that sarcomeres exhibit dislocations in registration and occasionally more complex helicoidal topology. T... |
2,323,212 | Deferoxamine treatment for intracerebral hemorrhage in aged rats: therapeutic time window and optimal duration. | Deferoxamine (DFX) reduces brain edema, neurological deficits, and brain atrophy after intracerebral hemorrhage (ICH) in aged and young rats. Our previous study found that 50 mg/kg is an effective dose in aged rats. In the present study, we explored potential therapeutic time windows and optimal therapeutic durations.<... |
2,323,213 | Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy. | The binge-drinking model in rodents using intragastric injections of ethanol (EtOH) for 4 days results in argyrophilic corticolimbic tissue classically interpreted as indicating irreversible neuronal degeneration. However, recent findings suggest that acquired argyrophilia can also identify injured neurons that have th... |
2,323,214 | Simultaneous choroid plexus carcinoma and pilocytic astrocytoma in a pediatric patient. | Simultaneous primary brain tumors in pediatric patients without prior chemotherapy or radiotherapy, phacomatosis, or known familial history are a rare occurrence. The authors report the case of a 4-year-old boy with simultaneous choroid plexus carcinoma and pilocytic astrocytoma with features of oligodendroglioma. Magn... |
2,323,215 | Rosette-forming glioneuronal tumors of the posterior fossa. | Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare, recently described WHO Grade I neoplasm. The authors report 6 examples of RGNT arising primarily from the cerebellar vermis. All the patients were female, and the mean age of presentation was 24.8 years. The original diagnoses included pilocyt... |
2,323,216 | Endoscopic third ventriculostomy: outcome analysis in 368 procedures. | Although endoscopic third ventriculostomy (ETV) has been accepted as a procedure of choice for the treatment of obstructive hydrocephalus, the outcome of this treatment remains controversial with regard to age, cause, and long-term follow-up results. The goal of this study was to assess the risk of failure associated w... |
2,323,217 | Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy. | Endoscopic biopsy with concomitant third ventriculostomy (ETV) is a well-established diagnostic and therapeutic maneuver in patients presenting with noncommunicating hydrocephalus resulting from a tumor of the pineal region or posterior third ventricle. Fenestration of the floor of the third ventricle theoretically pro... |
2,323,218 | Prevention of ventricular catheter obstruction and slit ventricle syndrome by the prophylactic use of the Integra antisiphon device in shunt therapy for pediatric hypertensive hydrocephalus: a 25-year follow-up study. | This 25-year follow-up study was performed on 120 children with hypertensive hydrocephalus to evaluate the influence of the early prophylactic implantation of the Integra antisiphon device (ASD, Integra Neurosciences Ltd.) on the rate of proximal shunt obstructions and the frequency of symptomatic slit ventricle syndro... |
2,323,219 | Is an endothelial nitric oxide synthase gene mutation a risk factor in the origin of intraventricular hemorrhage? | Studies have shown decreased levels of nitric oxide (NO), the product of endothelial NO synthase (eNOS) gene activity, in infants with respiratory conditions and intraventricular hemorrhage (IVH). The authors evaluated the association of the eNOS gene promoter polymorphism T-786C with the cause of these conditions (res... |
2,323,220 | Intracerebroventricular Transplantation of Cord Blood-Derived Neural Progenitors in a Child With Severe Global Brain Ischemic Injury. | Transplantation of neural stem/precursor cells has recently been proposed as a promising, albeit still controversial, approach to brain repair. Human umbilical cord blood could be a source of such therapeutic cells, proven beneficial in several preclinical models of stroke. Intracerebroventricular infusion of neutrally... |
2,323,221 | Focus on the brain: HIV infection and alcoholism: comorbidity effects on brain structure and function. | Both HIV infection and alcohol abuse have negative effects on the brain, with some unique to each condition and others shared by both conditions. Investigators have used magnetic resonance imaging to study the size and integrity of various brain structures in participants with alcoholism, HIV infection, or both conditi... |
2,323,222 | Bullet embolisation from injured inferior cava vein to the right ventricle. | Gunshot injuries of the human body challenge surgical teams in the emergency department. Since such injuries do not follow any rule, every patient should be considered a special case. Our case, of bullet embolism from injured inferior cava vein to the right heart ventricle is a rare one. Such cases make us be more aler... |
2,323,223 | Extraventricular neurocytomas. | Central neurocytomas are uncommon, benign tumours of the central nervous system. These tumours have been recognised outside the limits of the cerebral ventricles and, in these instances, have been called as 'extraventricular neurocytomas'. The authors described a case of frontal neurocytoma and discuss the current know... |
2,323,224 | Asymptomatic supratentorial arachnoid cyst and symptomatic demyelination plaques: which one needs treatment? | Intracranial arachnoid cysts are rare but the widespread use of brain imaging has disclosed many asymptomatic cysts. The authors report the case of a 37-year-old woman who presented with features suggestive of relapsing-remitting multiple sclerosis (MS). Her brain MRI revealed a moderately large arachnoid cyst in the r... |
2,323,225 | Temporal lobe lesions and psychosis in multiple sclerosis. | Lesions in the temporal lobe are associated with psychiatric manifestations in multiple sclerosis. The authors describe this case of a young man with multiple sclerosis who presented with first-episode psychosis and had acute lesions in the temporal lobe. He was successfully treated with olanzapine and β-interfer... |
2,323,226 | Cleft palate, arachnoid cyst and posterior urethral valve. | A 5-month-old infant presented with cleft palate, febrile urinary tract infection and abnormal movements. His urinary stream was poor and investigations revealed posterior urethral valve and grade V vesicoureteric reflux. This baby was investigated for seizure activity and on MRI of the brain was found to have a large ... |
2,323,227 | Heart laceration during oesophagectomy for the treatment of oesophageal carcinoma. | Oesophagectomy remains an acceptable treatment option for oesophageal cancer. However, it is associated with relatively high morbidity with potentially devastating complications, especially for patients who have undergone previous thoracic surgery. The majority of these complications, however, can be minimised by preve... |
2,323,228 | Cryptococcus meningitis in an immunocompetent teenage boy presented early with diplopia. | To report a case of cryptococcus meningitis in an immunocompetent teenager that presented early with diplopia and bilateral poor vision.</AbstractText>A case report</AbstractText>A 17-year-old boy presented with blurring of vision in both eyes and diplopia for 3 weeks. It was associated with severe throbbing headaches,... |
2,323,229 | Schwannoma of the third ventricle - a case report. | Summary Schwannomas represent about 8 % of all intracranial tumours, however, ventricular location of schwannomas is extremely rare. If they occur, they are located mostly in the lateral ventricle. To our knowledge there was only one case of third ventricular schwannoma described in the literature. Our case is the seco... |
2,323,230 | Anterior & lateral extension of optic radiation & safety of amygdalohippocampectomy through middle temporal gyrus: a cadaveric study of 11 cerebral hemispheres. | This is a cadaveric anatomical study on the localization of the optic radiation within the temporal lobe and to find whether surgical intervention to the temporal lobe, especially amygdalohippocampectomy, can damage the optic radiation or not.</AbstractText>11 cadaveric cerebral hemispheres were used for the study. A 2... |
2,323,231 | Cystic hemangioblastoma of the brainstem. | Hemangioblastomas are very highly vascular neoplasm with benign characteristics and; in comparison to cerebellar hemangioblastoma; cases of cystic hemangioblastoma of the brain stem are rare with only a few case reports available in the literature. We report the case of a 43-year-old-female with cystic hemagioblastoma ... |
2,323,232 | Alternative oblique head CT scanning technique reduces bone artifact and improves interpretability of brainstem anatomy. | Brainstem pathology due to infections, infarcts and tumors are common in developing countries, but neuroimaging technology in these resource-poor settings is often limited to single slice, and occasionally spiral, CT. Unlike multislice CT and MRI, single slice and spiral CT are compromised by bone artifacts in the post... |
2,323,233 | Restrictive cardiomyopathy--an outdated concept? | Restrictive cardiomyopathy is probably the least common of all cardiomyopathies, with a nonspecific clinical presentation and a frequently unknown cause. The concept of RCM has changed tremendously over time. Today it includes a large panel of disorders characterized by a non-hypertrophied, non-dilated cardiac phenotyp... |
2,323,234 | Nestin reporter transgene labels multiple central nervous system precursor cells. | Embryonic neuroepithelia and adult subventricular zone (SVZ) stem and progenitor cells express nestin. We characterized a transgenic line that expresses enhanced green fluorescent protein (eGFP) specified to neural tissue by the second intronic enhancer of the nestin promoter that had several novel features. During emb... |
2,323,235 | [Changes in the activity of the ciliary apparatus of the cerebral aqueduct ependymal cells induced by some cerebrospinal fluid neurotransmitters]. | In vitro investigation of the effect of the neurotransmitter amino acids on motile activity of the ciliary apparatus of cerebral (Sylvian) aqueduct ependymal cells in the newborn rats has shown that the addition of glutamate, GABA, glycine, and taurine to the nutrient medium induced deceleration and, finally, complete ... |
2,323,236 | [Glial reaction in the forebrain subventricular zone in the rat model of Alzheimer's disease].<Pagination><StartPage>24</StartPage><EndPage>28</EndPage><MedlinePgn>24-8</MedlinePgn></Pagination><Abstract><AbstractText>The purpose of this study was to investigate the long-term reactive changes in the subventricular zone... | The purpose of this study was to investigate the long-term reactive changes in the subventricular zone (SVZ) of the rat brain lateral ventricles after the intraventricular injection of beta-amyloid peptide (BAP). It was found that 3 months after BAP injection ependymal cells and SVZ cells reacted to the intraventricula... |
2,323,237 | [Structural MRI changes in children with epilepsy aged 2-18 years]. | Epilepsy can be one of symptoms of the damage to CNS in children, therefore neuroradiological examinations are necessary to complete diagnostics. The guidelines for imaging children with recent-onset epilepsy were published by experts of International League Against Epilepsy.</AbstractText>The aim of this retrospective... |
2,323,238 | [Three-dimensional sonoembryology--myth or reality]. | To describe the normal development of the embryonic central nervous system (CNS) using three-dimensional (3D) transvaginal (TV) ultrasound (US) between 7 and 10 w.g. and to compare the embryonic development visualized by 3D TV US with that of the classical embryology.</AbstractText>A prospective longitudinal study was ... |
2,323,239 | Mild Cognitive Disorders are Associated with Different Patterns of Brain asymmetry than Normal Aging: The PATH through Life Study. | Defining how brain structures differ in pre-clinical dementia is important to better understand the pathological processes involved and to inform clinical practice. The aim of this study was to identify significant brain correlates (volume and asymmetry in volume) of mild cognitive disorders when compared to normal con... |
2,323,240 | Thyroid hormones in the cerebrospinal fluid of the third ventricle of adult female sheep during different periods of reproductive activity. | Thyroid hormones (THs) are obligatory for transition from breeding season to anestrus in sheep. In this process, THs act during a very limited time of the year and primarily within the brain. In ewes chronically equipped for sampling cerebrospinal fluid (CSF) from the third ventricle, we have characterized the concentr... |
2,323,241 | Cardiac MRI reference values for athletes and nonathletes corrected for body surface area, training hours/week and sex. | To establish cardiac MRI reference values for endurance athletes and nonathletes, and study the impact of variables related to ventricular volumes and wall-mass.</AbstractText>Three hundred and thirty-six prospectively recruited healthy individuals aged 18-39 years (mean age 26+/-6 years, 46% women) underwent cardiac M... |
2,323,242 | [Effects of hydrocortisone on myocardial function in early stage of sepsis in rabbits]. | To study the effects of different dose of hydrocortisone (HC) on myocardial function in early stage of sepsis in rabbits.</AbstractText>Twenty-four male rabbits were randomly divided into three groups: model group (n=8), HC low dosage group (10 mg/kg, n=8), HC high dosage group (100 mg/kg, n=8). The model was reproduce... |
2,323,243 | GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex. | A subpopulation of glial fibrillary acidic protein (GFAP)-expressing cells located along the length of the lateral ventricles in the subventricular zone (SVZ) have been identified as the multipotent neural stem cells of the adult mammalian brain. We have previously found that, in the adult human brain, a splice variant... |
2,323,244 | Cerebral phaeohyphomycosis in a green iguana (Iguana iguana). | Cerebral phaeohyphomycosis was diagnosed in a 4-year-old green iguana (Iguana iguana) with paroxysmal spastic paralysis of all limbs and circling motion. Formalin-fixed tissues were collected at necropsy examination and submitted for evaluation. The left cerebrum and the left ventricle were replaced by a solid brown co... |
2,323,245 | Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse. | Tenascin-X (Tn-X) belongs to the tenascin family of glycoproteins and has been reported to be significantly associated with schizophrenia in a single nucleotide polymorphism analysis in humans. This finding indicates an important role of Tn-X in the central nervous system (CNS). However, details of Tn-X localization ar... |
2,323,246 | Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances. | To compare the predictivity of the neuroactive steroids in the cerebrospinal fluid and peripheral blood for the diagnostics of CNS disturbances, eighteen unconjugated steroids were quantified in the cerebrospinal fluid (CSF) from the 3rd ventricle and 18 unconjugated steroids and 7 steroid polar conjugates were measure... |
2,323,247 | Clinical features and management of five patients with supratentorial subependymoma. | Subependymoma is a rare low-grade glioma of the central nervous system that is often asymptomatic and discovered incidentally. If symptomatic, however, its clinical features vary widely. We report and discuss the management of five surgical patients (two males and three females, 27-65 years old). All tumors developed s... |
2,323,248 | Seeding metastases of a benign intraventricular meningioma along the surgical track. | Seeding metastases of a benign intraventricular meningioma along the surgical track is rare. We report a patient with a benign fibroblastic intraventricular meningioma that had spread along the path of previous surgery; the recurrences as well as the primary tumor were benign. |
2,323,249 | Ependymal cyst in the conus medullaris. | The immunohistological features and surgical treatment of an intramedullary ependymal cyst in the conus medullaris is presented. An intramedullary ependymal cyst is a rare lesion of dysembryoplastic origin. There have been only seven patients reported with pathologically proven ependymal cysts in the conus medullaris. ... |
2,323,250 | Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation. | Patients with Joubert syndrome 2 (JBTS2) suffer from a neurological disease manifested by psychomotor retardation, hypotonia, ataxia, nystagmus, and oculomotor apraxia and variably associated with dysmorphism, as well as retinal and renal involvement. Brain MRI results show cerebellar vermis hypoplasia and additional a... |
2,323,251 | Activation of central CRF receptor 1 by cortagine results in enhanced passive coping with a naturalistic threat in mice. | CRF receptor subtype 1 (CRF1), abundantly expressed in the central nervous system, has been implicated in defensive behavior in rodents. Pharmacological activation of CRF1 by peptidic agonists results in enhancement of anxiety-like behavior. However, receptor specificity of commonly used agonists was confounded by sign... |
2,323,252 | Abnormalities of tau-protein and beta-amyloid in brain ventricle cerebrospinal fluid. | Determination of various biomarkers, such as beta-amyloid, tau-protein, phosphorylated tau-protein in CSF and their sensitivity and specificity in neurodegenerative brain processes, in particular Alzheimer Dementia (AD), has been recently investigated to monitor their abnormalities in the CSF at early stages of disease... |
2,323,253 | Insulin-like growth factor-1 stimulation of hypothalamic KiSS-1 gene expression is mediated by Akt: effect of alcohol. | Kisspeptin, as well as insulin-like growth factor-1 (IGF-1), act centrally to stimulate luteinizing hormone-releasing hormone (LHRH) secretion at puberty. IGF-1 can induce KiSS-1 gene expression as an early pubertal event; however, the signaling pathway mediating this effect is not known. Since alcohol (ALC) blocks IGF... |
2,323,254 | Intermittent MTII application evokes repeated anorexia and robust fat and weight loss. | Central melanocortins (MC) evoke potent but transient anorectic responses with tachyphylaxis developing within days. We hypothesized that intermittent therapy using the MC analog, melanotan II (MTII), would minimize the tachyphylaxis and enhance the long-term efficacy of MTII treatment. F344/BN rats were infused with M... |
2,323,255 | Integration of human model neurons (NT2) into embryonic chick nervous system. | Postmitotic neurons were generated from the human NT2 teratocarcinoma cell line in a novel cell aggregate differentiation procedure. Approximately a third of the differentiated neurons expressed cell markers related to cholinergic neurotransmission. To examine whether this human cell model system can be directed toward... |
2,323,256 | Left ventricular noncompaction: a rare disorder in adults and its association with 1p36 chromosomal anomaly. | We report on a case of a 25-year-old male with 1p36 deletion syndrome, who was diagnosed with left ventricular noncompaction (LVNC). The association of this rare chromosomal abnormality with LVNC is reported in the pediatric literature, but it has not previously been specifically reported in adults. It is important to ... |
2,323,257 | Changes in cell proliferation in the subventricular zone of the brain in adult rats given beta-amyloid peptide (25-35). | The effects of intracerebroventricular administration of fragment (25-35) of beta-amyloid peptide [Abeta(25-35)] on cell proliferation in the subventricular zone of the dentate gyrus of the hippocampus in adult rats were analyzed. Animals received doses of 15 nmol of pre-aggregated Abeta(25-35) or the Abeta(35-25) cont... |
2,323,258 | Effects of gamma-aminobutyric acid on the Hering-Breuer inspiration-inhibiting reflex. | Acute experiments on rats were performed to study the effects of intraventricular microinjections of gamma-aminobutyric acid (GABA) on the volume-time parameters of external respiration and the inspiration-inhibiting Hering-Breuer reflex. The state of this reflex before and after GABA administration was assessed in ter... |
2,323,259 | Choroid plexus: biology and pathology. | The choroid plexus is an epithelial-endothelial vascular convolute within the ventricular system of the vertebrate brain. It consists of epithelial cells, fenestrated blood vessels, and the stroma, dependent on various physiological or pathological conditions, which may contain fibroblasts, mast cells, macrophages, gra... |
2,323,260 | Calpain inhibition reduces axolemmal leakage in traumatic axonal injury. | Calcium-induced, calpain-mediated proteolysis (CMSP) has recently been implicated to the pathogenesis of diffuse (traumatic) axonal injury (TAI). Some studies suggested that subaxolemmal CMSP may contribute to axolemmal permeability (AP) alterations observed in TAI. Seeking direct evidence for this premise we investiga... |
2,323,261 | [Endogenous repair mechanisms in the brain]. | Most of neurons are generated by neural stem cells in the developing brain at the embryonic or neonatal stages. However, recent studies indicate that adult brain also contains neural stem cells that continuously generate new neurons. Neurogenesis can be observed in the adult subventricular zone (SVZ) at the lateral wal... |
2,323,262 | Congenital eye malformations associated with extensive periocular neural crest apoptosis after influenza B virus infection during early embryogenesis. | Congenital eye malformations are a leading cause of blindness in children. Influenza virus infections prevail worldwide and have been implicated in congenital defects. Infections acquired during gestation may disrupt eye morphogenesis. We investigated the effects of influenza B virus infection on eye malformations duri... |
2,323,263 | Rat Dlx5 is expressed in the subventricular zone and promotes neuronal differentiation. | The molecular mechanisms and potential clinical applications of neural precursor cells have recently been the subject of intensive study. Dlx5, a homeobox transcription factor related to the distal-less gene in Drosophila, was shown to play an important role during forebrain development. The subventricular zone (SVZ) i... |
2,323,264 | Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. | Fibrillogenesis was induced in rats by injection of a fragment of neurotoxic protein, beta-amyloid protein precursor, into the cerebral ventricle. Copper, iron, and zinc concentrations and relative activities of genes of copper-transporting protein and extracellular and intracellular cuproenzymes were evaluated in diff... |
2,323,265 | Acute effects of fine particles on cardiovascular system: differences between the spontaneously hypertensive rats and wistar kyoto rats. | The study is to explore the potential mechanisms linking fine particles and cardiovascular toxicity. Spontaneous hypertensive rats (SHR) and age-matched wistar kyoto (WKY) rats were exposed by intratracheal instillation to fine particles with the doses of 0.0, 1.6, 8.0 and 40.0mg/kg b.w., respectively. The exposure was... |
2,323,266 | Ependymal cells: biology and pathology. | The literature was reviewed to summarize the current understanding of the role of ciliated ependymal cells in the mammalian brain. Previous reviews were summarized. Publications from the past 10 years highlight interactions between ependymal cells and the subventricular zone and the possible role of restricted ependyma... |
2,323,267 | Perforation holes in ventricular catheters--is less more? | Obstruction is a common cause of cerebrospinal fluid (CSF) shunt failure. Risk factors for proximal obstructive malfunction are suboptimal ventricular catheter positioning and slit-like ventricles. A new ventricular catheter design to decrease risk of obstruction was evaluated.</AbstractText>A review of histopathologic... |
2,323,268 | Manganese-enhanced magnetic resonance imaging in experimental spinal cord injury: correlation between T1-weighted changes and Mn(2+) concentrations. | Manganese (Mn(2+))-enhanced magnetic resonance imaging (MEMRI) is a potentially important tool for assessing neural tissue regeneration after spinal cord injury (SCI). We evaluated the relation between Mn(2+) and T1-weighted magnetic resonance (MR) signals in an SCI rat model.</AbstractText>Rats were divided into 4 gro... |
2,323,269 | Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients. | To review our experience of managing idiopathic normal pressure hydrocephalus (iNPH) during the 6-year period from 2002 to 2007, when intracranial pressure (ICP) monitoring was part of the diagnostic workup.</AbstractText>The review includes all iNPH patients undergoing diagnostic ICP monitoring during the years 2002 t... |
2,323,270 | Endogenous regulation of neural stem cells in the adult mammalian brain. | Tissue-specific stem cells replenish organs by replacing cells lost due to tears and wears or injury throughout life. Long considered as an exception to this rule, the adult mammalian brain has consistently been found to possess stem cells that ensure neurogenesis. Neural stem cells persist within the subventricular zo... |
2,323,271 | Progressive structural brain changes in schizophrenia. | Several important progressive brain changes occur in schizophrenia. Continuous progressive brain tissue decreases and lateral ventricular volume increases in chronically ill patients, up to at least 20 years after their first symptoms. The total duration of psychosis may be negatively associated with the grey matter vo... |
2,323,272 | The modulatory effects of bHLH transcription factors with the Wnt/beta-catenin pathway on differentiation of neural progenitor cells derived from neonatal mouse anterior subventricular zone. | The subventricular zone (SVZ) located adjacent to the lateral ventricles is the major site where neural progenitor cells (NPCs) are concentrated in the adult brain. NPCs in the anterior subventricular zone (SVZa) generate neuronal precursors and migrate along a highly localized pathway--the rostral migratory stream (RM... |
2,323,273 | Long-term evaluation of a new ventriculoperitoneal shunt valve system in a dog. | To report on the use of a new ventriculoperitoneal shunt (VPS) valve system utilized in a dog with hydrocephalus and to describe the clinical course over 20 months after implantation.</AbstractText>A 3-month-old female Lhasa Apso dog was presented with lateral strabismus, domed calvarium, and visual deficits. A lateral... |
2,323,274 | [Experimental study of implantation of neurotropin-3 modified olfactory ensheathing cells in experimental allergic encephalomyelitis]. | To investigate the therapeutic effect of neurotrophin-3 (NT-3) modified olfactory ensheathing cell (OEC) upon experimental allergic encephalomyelitis (EAE).</AbstractText>OEC-NT-3 gene engineering cell, constructed by neurotrophin-3 transinfecting GEC inducted by retrovirus, was transplanted into lateral ventricle. The... |
2,323,275 | Agenesis of the corpus callosum in fetuses with mild ventriculomegaly: role of MR imaging. | We evaluated the role of magnetic resonance (MR) imaging in the diagnosis of corpus callosum agenesis - isolated or associated with other anomalies - in fetuses with mild cerebral ventriculomegaly, as depicted at prenatal sonography.</AbstractText>Between January 2005 and March 2007, 33 fetuses with a mean gestational ... |
2,323,276 | Anesthesia-induced neurodegeneration in fetal rat brains. | We investigated the extent of isoflurane-induced neurodegeneration on the fetuses of pregnant rats exposed in utero. Pregnant rats at gestational d 21 were divided into three experimental groups. Rats in the control group spontaneously breathed 100% oxygen for 1 h. Rats in the treatment groups breathed either 1.3 or 3%... |
2,323,277 | Transplanted neural precursors enhance host brain-derived myelin regeneration. | In multiple sclerosis lesions resident oligodendrocyte progenitor cells (OPCs) are present, but fail to remyelinate. In the current study we examined whether neural precursor cell (NPC) transplantation can facilitate host brain-derived remyelination. We used the chronic cuprizone-induced demyelination model in aged mic... |
2,323,278 | Distribution of EFHC1 or Myoclonin 1 in mouse neural structures. | EFHC1, a gene mutated in juvenile myoclonic epilepsy, encodes EFHC1, a protein with three DM10 domains and one EF-hand motif. We recently demonstrated that this molecule is a microtubule-associated protein (MAP) implicated in neuronal migration. Because some controversies persist about the precise localization in the C... |
2,323,279 | A remnant sewing needle in the right ventricle as a cause of chest pain. | Sewing needles, albeit a rare case of penetrating cardiac injury, are potentially life-threatening. We report a case of a self-inflicted remnant intracardiac sewing needle which is diagnosed with nonspecific chest pain and successfully extracted 23 months after its insertion. |
2,323,280 | Fowler syndrome-a clinical, radiological, and pathological study of 14 cases. | We report on 14 fetuses from 10 families with the autosomal recessive syndrome of proliferative vasculopathy and hydranencephaly-hydrocephaly (Fowler syndrome). In four families sibs were affected and in six the parents were consanguineous. Antenatal ultrasonography showed hydrocephaly in all except two fetuses, but hy... |
2,323,281 | Postmortem imaging: MDCT features of postmortem change and decomposition. | Multidetector computed tomography (MDCT) has emerged as an effective imaging technique to augment forensic autopsy. Postmortem change and decomposition are always present at autopsy and on postmortem MDCT because they begin to occur immediately upon death. Consequently, postmortem change and decomposition on postmortem... |
2,323,282 | Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment. | Rodents exhibit aversive behavior toward a diet that lacks at least one of the essential amino acids. We sought to determine whether the particular form of anorexia caused by such diets could be ameliorated by the administration of orexigenic peptides while simultaneously analyzing the neural mechanisms underlying anor... |
2,323,283 | 4-Hydroxytamoxifen inhibits K(+) currents in mouse ventricular myocytes. | Tamoxifen is a widely used chemotherapeutic agent, which has been associated with prolongation of the QT interval. Other studies have reported that acute exposure to tamoxifen can reduce cardiac K(+) currents. However, in vivo tamoxifen is largely metabolized and most of its activity is attributable to its major metabo... |
2,323,284 | Melatonin is released in the third ventricle in humans. A study in movement disorders. | In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, d... |
2,323,285 | Reduced cerebellar diameter in very preterm infants with abnormal general movements. | Abnormal General Movements (GMs) early in life are predictive of later neuromotor deficits and are related to white matter abnormalities on magnetic resonance imaging (MRI). However, other structural correlates of abnormal GMs have not been defined.</AbstractText>The objective of this study was to explore brain-metrics... |
2,323,286 | Tomotherapy and multifield intensity-modulated radiotherapy planning reduce cardiac doses in left-sided breast cancer patients with unfavorable cardiac anatomy. | For patients with left-sided breast cancers, radiation treatment to the intact breast results in high doses to significant volumes of the heart, increasing the risk of cardiac morbidity, particularly in women with unfavorable cardiac anatomy. We compare helical tomotherapy (TOMO) and inverse planned intensity modulated... |
2,323,287 | Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. | Targeted gene therapy can potentially minimize undesirable off-target toxicity due to specific delivery. Neuron-specific gene delivery in the central nervous system is challenging because neurons are non-dividing and also outnumbered by glial cells. One approach is to transfect dividing neural stem and progenitor cells... |
2,323,288 | Hypertonic mannitol in mice poisoned by a convulsive dose of soman: antilethal activity without neuroprotection. | A convulsive dose of soman induces seizure-related brain damage (SRBD), including cerebral edema (CE) and cell death. In 1993, an American study demonstrated that hypertonic mannitol (Mann) intravenously (i.v.) administered 1 min and 5h post-soman was an effective neuroprotectant in intoxicated rats. Using a similar pr... |
2,323,289 | Intraventricular infusion of hyperosmolar dextran induces hydrocephalus: a novel animal model of hydrocephalus. | Popular circulation theory of hydrocephalus assumes that the brain is impermeable to cerebrospinal fluid (CSF), and is therefore incapable of absorbing the CSF accumulating within the ventricles. However, the brain parenchyma is permeable to water due to the presence of specific ion channels as well as aquaporin channe... |
2,323,290 | Strongyloides stercoralis hyperinfection: difficulties in diagnosis and treatment. | Immunocompromised patients who are infected with Strongyloides stercoralis may develop a potentially fatal auto-infection syndrome characterised by non-specific pulmonary and gastrointestinal symptoms and Gram negative sepsis. We present the case of one such patient who underwent a negative laparotomy for a presumed in... |
2,323,291 | Migrated sternal wire into the right ventricle: case report in cardiothoracic surgery. | Migrating wires as a result of sternal nonunion present clinical challenges. Cardiac Computed Tomographic Angiography helps locate these wires precisely, enabling detailed surgical planning. Sternal wire migration is an infrequent complication following median sternotomy. It is usually encountered among patients with s... |
2,323,292 | Three-dimensional culture alters primary cardiac cell phenotype. | The directed formation of complex three-dimensional (3D) tissue architecture is a fundamental goal in tissue engineering and regenerative medicine. The growth of cells in 3D structures is expected to influence cellular phenotype and function, especially relative cell distribution, expression profiles, and responsivenes... |
2,323,293 | Vascular endothelial growth factor is involved in mediating increased de novo hippocampal neurogenesis in response to traumatic brain injury. | Stimulating the endogenous repair process after traumatic brain injury (TBI) can be an important approach in neuroregenerative medicine. Vascular endothelial growth factor (VEGF) is one of the molecules that can increase de novo hippocampal neurogenesis. Here, we tested whether VEGF signaling through Flk1 (VEGF recepto... |
2,323,294 | Superficial siderosis of the central nervous system after ventriculoperitoneal shunt. | The authors report a case of superficial siderosis of the CNS that developed after ventriculoperitoneal (VP) shunt placement for normal-pressure hydrocephalus. A 65-year-old woman had undergone VP shunt insertion for normal-pressure hydrocephalus. Her gait disturbance, memory disturbance, and urinary incontinence all i... |
2,323,295 | Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats. | As one of the most studied protein hormones, insulin as well as its receptor have been known to play key roles in a variety of important biological processes. Detection of insulin and its receptor in the central nervous system (CNS) has led to a rapidly growing interest in the central effects of insulin. Insulin and it... |
2,323,296 | Pulmonary capillary hemangiomatosis in chronic cardiac failure due to aortic stenosis.<Pagination><StartPage>339</StartPage><EndPage>344</EndPage><MedlinePgn>339-44</MedlinePgn></Pagination><Abstract><AbstractText>We report a case of pulmonary capillary hemangiomatosis in a patient with aortic stenosis. An 86-year-old ... | We report a case of pulmonary capillary hemangiomatosis in a patient with aortic stenosis. An 86-year-old Japanese female with chronic heart failure due to aortic stenosis suddenly died during hemodialysis. At an autopsy, severe aortic stenosis and cardiomegaly with both left and right ventricular hypertrophy were note... |
2,323,297 | Kaposi sarcoma related to an ectopic hypothalamic adrenocorticotropic hormone-secreting adenoma: case report. | We aim to report a case of Kaposi sarcoma (KS) with Cushing's syndrome caused by endogenic glucocorticoid-induced immunosuppression.</AbstractText>A 43-year-old woman presented with delirium, hirsutism, fatigue, and hypertension. At the time of presentation, physical findings showed a Cushingoid appearance, with moon-l... |
2,323,298 | Detection of intraventricular blood using EIT in a neonatal piglet model. | We have developed a sensitive EIT protocol for detection of intraventricular bleeding. A common model of human neonates is the neonatal piglet. We used our method to test the sensitivity of our method and device to small amounts of blood-like fluid injected near the left and right ventricles of a piglet cadaver. Compar... |
2,323,299 | Potentials and limitations of ventricular torsion as indicator of cardiac function. | New non-invasive imaging techniques allow quantification of torsion of the left ventricle (LV). Presently, it is not well know what torsion can add as an indicator of left ventricular pump function. A frame work for understanding of cardiac motion has been designed that is based on general principles of mechanics. In t... |
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