Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,323,500 | Mini-mental state examination is sensitive to brain atrophy in Alzheimer's disease. | <AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">Screening instruments such as the Mini-Mental State Examination (MMSE) are useful for the early identification of Alzheimer's disease (AD). We tested whether macrostructural differences in brain volume are related to the MMSE.</AbstractText>The MMSE was rela... |
2,323,501 | Localization of angiopoietin-1 and Tie2 immunoreactivity in rodent ependyma and adjacent blood vessels suggests functional relationships. | Angiopoietin-1 (Angpt1; previously Ang-1) participates in vascular maintenance and remodeling. In the current study, we investigated the distribution of Angpt1 protein in rat brain. We detected Angpt1 immunoreactivity (IR) in cerebral blood vessels, cuboidal ependyma, and tanycytes, which are specialized hypothalamic b... |
2,323,502 | Third ventriculostomy in a single pediatric surgical unit. | Endoscopic third ventriculostomy (ETV) is a successful method of treatment for obstructive hydrocephalus that has become popular over the last 20 years. The purpose of this paper is to study the outcome of infants with obstructive hydrocephalus treated by ETV by a single surgeon and to evaluate the safety, reliability,... |
2,323,503 | Phase-contrast MR studies of CSF flow rate in the cerebral aqueduct and cervical subarachnoid space with correlation-based segmentation. | Accurate measurement of cerebrospinal fluid (CSF) flow rate elucidates pathophysiological changes in the intracranial environment and is thus clinically useful. We investigated the feasibility of correlation coefficient (CC) analysis for extracting CSF lumens in the cerebral aqueduct and cervical subarachnoid space (SA... |
2,323,504 | Effect of central microinjection of carbenoxolone in an experimental model of focal cerebral ischemia. | Previous experimental studies have shown the protective effects of CBX on brain ischemic injures in global and in vitro models of ischemia. However, effects of CBX in temporary model of focal cerebral ischemia are not clear. Hence, the aim of this study was to investigate the effects of central microinjection of CBX on... |
2,323,505 | Endoscopy in the management of intra-ventricular lesions: preliminary experience in the Middle East. | The study is aimed at evaluating neuroendoscopic procedures in the management of various intra-cranial intra-ventricular lesions.</AbstractText>We retrospectively review 24 consecutive patients harboring various intra-ventricular lesions with or without associated hydrocephalus, operated and managed by the authors betw... |
2,323,506 | Neurogenesis and astrogenesis contribution to recovery of vestibular functions in the adult cat following unilateral vestibular neurectomy: cellular and behavioral evidence. | In physiological conditions, neurogenesis occurs in restricted regions of the adult mammalian brain, giving rise to integrated neurons into functional networks. In pathological or postlesional conditions neurogenesis and astrogenesis can also occur, as demonstrated in the deafferented vestibular nuclei after immediate ... |
2,323,507 | Hypoxia and myocardial remodeling in human cardiac allografts: a time-course study. | Cardiac allografts are known to develop myocardial fibrosis, which may be a cause of progressive cardiac dysfunction. Apart from the renin-angiotensin and transforming growth factor-beta system, hypoxia has been proposed as an important player in the pathogenesis of fibrosis, but its significance remains unclear. This ... |
2,323,508 | Midline brain abnormalities in established bipolar affective disorder. | Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present.</AbstractText>We used magnetic resonance imaging to investigate the size of the adhesio interthalamica (AI) and cavum... |
2,323,509 | Insulin and IGF-I prevent brain atrophy and DNA loss in diabetes. | The aim of this study was to identify factors that regulate the bulk of adult brain mass, and test the hypothesis that concomitantly reduced insulin and insulin-like growth factor (IGF) levels are pathogenic for brain atrophy associated with impaired learning and memory in diabetes. Doses of insulin, or insulin plus IG... |
2,323,510 | Optimal microsurgical treatment of dorsum sellae meningioma. | There are few reports of microsurgical treatment of dorsum sellae meningiomas-which, because of location, size, and differences in growth direction, clinical presentations, degree of surgical difficulty, have varied posttreatment sequelae. In pursuit of an optimal microsurgical treatment option for dorsum sellae mening... |
2,323,511 | Chemically based mathematical model for development of cerebral cortical folding patterns. | The mechanism for cortical folding pattern formation is not fully understood. Current models represent scenarios that describe pattern formation through local interactions, and one recent model is the intermediate progenitor model. The intermediate progenitor (IP) model describes a local chemically driven scenario, whe... |
2,323,512 | Involvement of hydrogen peroxide in the manganese-induced myocytes mitochondrial membrane potential loss. | Isolated rat ventricular myocytes were incubated in different manganese concentrations and after that the reactive oxygen species (ROS) generation, the level of reduced glutathione (GSH), and the changes of mitochondrial membrane potential (Deltapsi m) were investigated by a flow cytometer (FACScan) as well as laser sc... |
2,323,513 | Heterogeneity in subcortical brain development: A structural magnetic resonance imaging study of brain maturation from 8 to 30 years. | Brain development during late childhood and adolescence is characterized by decreases in gray matter (GM) and increases in white matter (WM) and ventricular volume. The dynamic nature of development across different structures is, however, not well understood, and the present magnetic resonance imaging study took advan... |
2,323,514 | A longitudinal observational study of brain atrophy rate reflecting four decades of multiple sclerosis: a comparison of serial 1D, 2D, and volumetric measurements from MRI images. | Multiple sclerosis (MS) has a variable progression with an early onset of atrophy. Individual longitudinal radiological evaluations (over decades) are difficult to perform due to the limited availability of magnetic resonance imaging (MRI) in the past, patients lost in follow-up, and the continuous updating of scanners... |
2,323,515 | A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. | Polycystin-1 (PC-1), the product of the PKD1 gene, mutated in the majority of cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD), is a very large (approximately 520 kDa) plasma membrane receptor localized in several subcellular compartments including cell-cell/matrix junctions as well as cilia. While heterol... |
2,323,516 | The subependymal zone neurogenic niche: a beating heart in the centre of the brain: how plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed. | The mammalian brain is a remarkably complex organ comprising millions of neurons, glia and various other cell types. Its impressive cytoarchitecture led to the long standing belief that it is a structurally static organ and thus very sensitive to injury. However, an area of striking structural flexibility has been rece... |
2,323,517 | The nucleus raphe magnus suppresses vomiting, and the solitary nucleus and 5-HT are not involved in this suppression. | In previous paper, we reported that stimulation of the nucleus raphe magnus (stim-NRM) inhibits the induction of retching by afferent vagal fibers (VAs). We performed the present study to identity the transmitter of inhibition and then the site. The following results were obtained in decerebrated and paralyzed dogs. 1)... |
2,323,518 | Forniceal glioma in children. Clinical article. | Five to ten percent of pediatric brain tumors are located in the ventricles. Among them, forniceal lesions are rare and their management has not often been described. The aim of this study was to review the clinical, radiological, and histopathological features as well as the feasibility of surgical excision and the ou... |
2,323,519 | Endoscopic transventricular positioning of intracystic catheter for treatment of craniopharyngioma. Technical note. | The intracystic injection of chemo- and radiotherapeutic agents was introduced for the treatment of craniopharyngioma to control tumor growth and to delay the potentially harmful effects of surgery or radiation therapy. The positioning of cyst catheters has been performed by means of direct vision, stereotactically gui... |
2,323,520 | Gene expression profiling: classification of mice with left ventricle systolic dysfunction using microarray analysis. | We tested the hypothesis that a set of differentially expressed genes could be used to classify mice according to cardiovascular phenotype after prolonged catecholamine stress.</AbstractText>Prospective, randomized study.</AbstractText>University-based research laboratory.</AbstractText>One hundred seventy-three male m... |
2,323,521 | Choroid plexus papilloma presenting as a non-contrast-enhancing fourth ventricular mass in a child. | Choroid plexus papilloma (CPP) is a rare benign tumor of the central nervous system with a propensity for location within the lateral ventricle in children. We report a case of a 14-year-old girl who presented with transient facial paresis and ataxia. Her imaging showed a non-enhancing intra fourth ventricular mass, th... |
2,323,522 | Expanding the clinical and neuroradiologic phenotype of primary microcephaly due to ASPM mutations. | To determine the spectrum of clinical, neuropsychological, and neuroradiologic features in patients with autosomal recessive primary microcephaly (MCPH) due to ASPM gene mutations.</AbstractText>ASPM was sequenced in 52 unrelated MCPH probands. In patients with ASPM mutations, we evaluated the clinical phenotype, cogni... |
2,323,523 | Resuscitation with Na+/H+ exchanger inhibitor in traumatic haemorrhagic shock: cardiopulmonary performance, oxygen transport and tissue inflammation. | 1. The aim of the present study was to examine the effects of inhibition of the Na(+)/H(+) exchanger (NHE-1) on cardiopulmonary performance, oxygen carrying capacity and tissue inflammation in a pig model of traumatic haemorrhage-resuscitation. 2. In 12 instrumented anaesthetized pigs, traumatic haemorrhage was modelle... |
2,323,524 | Neuroanatomy and volumes of brain structures of a live California sea lion (Zalophus californianus) from magnetic resonance images. | The California sea lion (Zalophus californianus) has been a focal point for sensory, communication, cognition, and neurological disease studies in marine mammals. However, as a scientific community, we lack a noninvasive approach to investigate the anatomy and size of brain structures in this species and other free-ran... |
2,323,525 | Fluoxetine effects on mitochondrial ultrastructure of right ventricle in rats exposed to cold stress. | To assess fluoxetine effects on mitochondrial structure of the right ventricle in rats exposed to cold stress.</AbstractText>The experimental study procedures were performed in 250-300g male EPM-Wistar rats. Rats (n=40) were divided into four groups: 1) Control group (CON); 2) Fluoxetine (FLU); 3) Induced hypothermia (... |
2,323,526 | Endoscopic management of hydrocephalus due to neurocysticercosis. | Hydrocephalus due to neurocysticercosis usually shows poor prognosis and shunt failure is a common complication. Neuroendoscopy has been suggested as treatment, but the indications remain unclear.</AbstractText>A cohort of patients with clinical/radiological diagnosis of hydrocephalus due to NCC, treated between Januar... |
2,323,527 | Electrophysiological development of transplanted embryonic stem cell-derived cardiomyocytes in the hearts of syngeneic mice. | We undertook this study in order to investigate the electrophysiological properties of grafted mouse embryonic stem cell (ES)-derived cardiomyocytes in mouse hearts.</AbstractText>We generated transgenic D3 ES cells that carry the alpha-myosin heavy-chain promoter-driven enhanced green fluorescent protein (EGFP) gene. ... |
2,323,528 | Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans? | Coordinated movements require the caudate-putamen and the globus pallidus, two nuclei belonging to the basal ganglia, to be intact and functioning properly. Many neurons populating these regions derive from the medial ganglionic eminence, a transient structure that expresses the transcription factor Nkx2.1 during prena... |
2,323,529 | Bilateral bulbar palsy and postural hypotension following surgery for fourth ventricle subependymoma. | We report a 54-year-old man who developed bilateral bulbar palsy and severe postural hypotension following resection of a fourth ventricle subependymoma. It is proposed that interruption of the function of the nucleus of the tractus solitarius (in which the baroreflex is integrated) may have been responsible for the po... |
2,323,530 | DJ-1 mRNA anatomical localization and cell type identification in the mouse brain. | Mutations in DJ-1 cause familial Parkinson's disease (PD). The expression pattern of DJ-1 in the brain remains controversial. In the present study, we used DJ-1 deficient mice as negative controls and examined DJ-1 mRNA expression in mouse brains. In sequential double labeling on the same sections, in situ hybridizatio... |
2,323,531 | Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. | Neurotransmitter release is regulated at a specific site in nerve terminals called the "active zone", which is composed of various cytomatrix proteins such as Piccolo (also known as Aczonin) and Bassoon. These proteins share regions of high sequence similarity and have very high molecular weights (>400 kDa). Since P... |
2,323,532 | Enhanced effect of neuropeptide Y on food intake caused by blockade of the V(1A) vasopressin receptor. | Food intake is regulated by various factors such as neuropeptide Y. Neuropeptide Y potently induces an increase in food intake, and simultaneously stimulates arginine-vasopressin (AVP) secretion in the brain. Recently, we reported that V(1A) vasopressin receptor-deficient (V(1A)R(-/-)) mice exhibited altered daily food... |
2,323,533 | Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis. | NR2A-containing N-methyl-D-aspartate (NMDA) receptors have important roles in influencing the long-term potentiation and spatial memory. Here using Morris water maze, we found that inhibition of NR2A-containing NMDA receptors by [(R)-[(S)-1-(4-bromophenyl)-ethylamino]-(2, 3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-meth... |
2,323,534 | Blocking hedgehog signaling after ablation of the dorsal neural tube allows regeneration of the cardiac neural crest and rescue of outflow tract septation. | Cardiac neural crest cells (CNCC) migrate into the caudal pharynx and arterial pole of the heart to form the outflow septum. Ablation of the CNCC results in arterial pole malalignment and failure of outflow septation, resulting in a common trunk overriding the right ventricle. Unlike preotic cranial crest, the postotic... |
2,323,535 | Suprasellar ganglioglioma presenting with diabetes insipidus in a young boy: a rare clinical presentation. | Gangliogliomas are rare tumors composed of an admixture of glial and neuronal components. These usually occur in young patients, who present with therapy-resistant seizures. Clinical presentation of ganglioglioma with diabetes insipidus is extremely rare with only one case reported earlier in the available literature. ... |
2,323,536 | A prospective study of fetuses with isolated ventriculomegaly investigated by antenatal sonography and in utero MR imaging. | Fetal ventriculomegaly (VM) is important because of its high prevalence and high risk of association with other brain abnormalities. The purpose of this article was to investigate the hypotheses that including in utero MR imaging (iuMR) in the diagnostic pathway for fetuses with isolated VM on antenatal imaging will sh... |
2,323,537 | Effects of developmental age, brain region, and time in culture on long-term proliferation and multipotency of neural stem cell populations. | Neural stem cells (NSCs) in the murine subventricular zone (SVZ) niche allow life-long neurogenesis. During the first postnatal month and throughout aging, the decrease of neuroblasts and the rise of astrocytes results in diminished neurogenesis and increased astrocyte:neuron ratio. Also, a different neurogenic activit... |
2,323,538 | Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress. | Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effe... |
2,323,539 | Peripheral osmotic stimulation inhibits the brain's innate immune response to microdialysis of acidic perfusion fluid adjacent to supraoptic nucleus. | During the brain's innate immune response microglia, astroglia and ependymal cells resolve/repair damaged tissue and control infection. Released interleukin-1beta (IL-1beta) reaching cerebroventricles stimulates circumventricular organs (CVOs; subfornical organ, SFO; organum vasculosum lamina terminalis, OVLT), the med... |
2,323,540 | Case report. Glioblastoma multiforme presenting as a haemorrhagic minimally enhancing mass of the trigone. | Tumours of the trigone are rare, representing less than 2.5% of all intracranial tumours. The most common cause in adults is a meningioma. Glioblastoma multiforme of the trigone is extremely rare, with only six cases reported in the literature. We present a case of a glioblastoma multiforme of the trigone presenting in... |
2,323,541 | Choroid plexus connexin 43 expression and gap junction flexibility are associated with clinical features of acute EAE. | Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zon... |
2,323,542 | Coagulation abnormalities and severe intraventricular hemorrhage in extremely low birth weight infants. | The association between intraventricular hemorrhage (IVH) and coagulation in infants has been a subject of controversy. Only few publications assessing risk factors for development of IVH reported results of coagulation studies.</AbstractText>To evaluate the levels of coagulation and fibrinolysis systems in ELBW infant... |
2,323,543 | Role of fetal MRI in the diagnosis of cerebral ventriculomegaly assessed by ultrasonography. | To evaluate the additional diagnostic value of fetal MRI to evaluate cerebral ventriculomegaly assessed by ultrasonography (US) for the possibility to change the diagnosis, the counseling and the management of pregnancy.</AbstractText>From february 2006 to october 2008, we studied 55 pregnant women by fetal MRI (mean a... |
2,323,544 | Phase-contrast MRI and 3D-CISS versus contrast-enhanced MR cisternography on the evaluation of the aqueductal stenosis. | In the current study, we aimed to compare the diagnostic efficacies of phase-contrast magnetic resonance imaging (PC-MRI) and three-dimensional constructive interference in steady-state (3D-CISS) sequence over detection of aqueductal stenosis (AS) on the basis of contrast-enhanced magnetic resonance cisternography (MRC... |
2,323,545 | Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity. | <AbstractText Label="AIMS/HYPOTHESIS" NlmCategory="OBJECTIVE">There is evidence from mouse models and humans that alterations in insulin action in the brain are accompanied by an obese phenotype; however, the impact of insulin with regard to behavioural aspects such as locomotion is unknown.</AbstractText>To address in... |
2,323,546 | Treatment modalities for leptomeningeal metastases. | Secondary involvement of the leptomeninges represents an infrequent but devastating (and nearly always fatal) complication of solid tumors, hematologic malignancies (both leukemia and lymphoma), and primary brain tumors. Clinical suspicion of neoplastic meningitis (NM) may be raised by the appearance of multivariate ne... |
2,323,547 | Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. | In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but t... |
2,323,548 | Subthalamic nucleus location: relationships between stereotactic AC-PC-based diagrams and MRI anatomy-based contours. | Subthalamic nucleus (STN) targeting is classically performed based on AC-PC probabilistic position. Nevertheless, MRI allows direct visualization and targeting. We aimed to compare the position localized on MR images with standard stereotactic diagrams. The STN was manually contoured on MR images (22 Parkinson's diseas... |
2,323,549 | Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. | The medial hypothalamus mediates leptin-induced glucose uptake in peripheral tissues, and brain melanocortin receptors (MCRs) mediate certain central effects of leptin. However, the contributions of the leptin receptor and MCRs in individual medial hypothalamic nuclei to regulation of peripheral glucose uptake have rem... |
2,323,550 | Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice. | Aceruloplasminemia is an autosomal recessive disorder caused by mutations in the ceruloplasmin (CP) gene. It is characterized by iron accumulation in the brain and in visceral organs. However, little is known about the mechanism of iron transport in these regions. Adult CP null (CP(-/-)) mice show increased iron deposi... |
2,323,551 | Cellular organization of the central canal ependymal zone, a niche of latent neural stem cells in the adult mammalian spinal cord. | A stem cell's microenvironment, or "niche," is a critical regulator of its behaviour. In the adult mammalian spinal cord, central canal ependymal cells possess latent neural stem cell properties, but the ependymal cell niche has not yet been described. Here, we identify important similarities and differences between th... |
2,323,552 | Altered neuronal activities in the motor cortex with impaired motor performance in adult rats observed after infusion of cerebrospinal fluid from amyotrophic lateral sclerosis patients. | Although definite evidences are available to state that, neuronal activity is a prime determinant of animal behavior, the specific relationship between local field potentials of the motor cortex after intervention with CSF from human patients and animal behavior have remained opaque. The present study has investigated ... |
2,323,553 | Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme: a report of 7 cases. | Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) has been broadly recognized as a beneficial tool for the resection of glioblastoma multiforme (GBM). Fluorescence in the ventricular walls, which were apparently free of macroscopic tumor or MR imaging enhancement indicative of CSF dissemination, was detec... |
2,323,554 | Molecular and functional remodeling of I(to) by angiotensin II in the mouse left ventricle. | The transient outward potassium current (I(to)) in cardiac myocytes is mainly mediated by members of the Kv4 subfamily of voltage-gated potassium channels. Several in vitro studies have shown that angiotensin II (Ang II), which plays an important role in the development of cardiac hypertrophy, rapidly downregulates Kv4... |
2,323,555 | Incidence of normal pineal and chroids plexus calcification on brain CT (computerized tomography) at Tikur Anbessa Teaching Hospital Addis Ababa, Ethiopia. | To determine the incidence of normal calcification of pineal gland and choroids plexus on Brain -CT (computerized Tomography) and to see its association with age and sex.</AbstractText>A cross-sectional descriptive study was conducted at Radiology Department, Tikur Anbessa Teaching Hospital, Addis Ababa, Ethiopia from ... |
2,323,556 | Comparision of results between two different techniques of cranio-cervical decompression in patients with Chiari I malformation. | A variety of approaches are employed for treatment of Chiari I malformation. They differ in extent of cranio-c ervical decompression. A technique based on arachnoid preservation and duroplasty was introduced in our department in 2001. The aim of the study is to compare between the previous and the present technique.</A... |
2,323,557 | Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury. | Neural stem and progenitor cells (NSPC) generate neurons and glia, a feature that makes them attractive for cell replacement therapies. However, efforts to transplant neural progenitors in animal models of brain injury typically result in high cell mortality and poor neuronal differentiation.</AbstractText>In an attemp... |
2,323,558 | L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. | Alzheimer's disease is the most common form of dementia. Amyloid-beta protein is considered as a key factor of pathogenesis of Alzheimer's disease. l-3-n-butylphthalide (L-NBP), an anti-cerebral ischemia drug, has been shown to have therapeutic effects in vascular dementia animal models. In the present study, we invest... |
2,323,559 | Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. | LPS given peripherally or into the brain induces a neuroinflammatory response. How peripheral LPS induces its effects on brain is not clear, but one mechanism is that LPS crosses the blood-brain barrier (BBB). Alternatively, LPS acts outside the BBB by stimulating afferent nerves, acting at circumventricular organs, an... |
2,323,560 | Automatic identification of the reference system based on the fourth ventricular landmarks in T1-weighted MR images. | The reference system based on the fourth ventricular landmarks (including the fastigial point and ventricular floor plane) is used in medical image analysis of the brain stem. The objective of this study was to develop a rapid, robust, and accurate method for the automatic identification of this reference system on T1-... |
2,323,561 | Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injury. | Post-traumatic epilepsy, partly due to the loss of hilar neurons of the hippocampus, is a frequent long-term consequence of traumatic brain injury (TBI). We and others found that the levels of vascular endothelial growth factor (VEGF) that can act as a neuroprotectant increase after TBI. Here we tested whether VEGF and... |
2,323,562 | A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease. | A common problem faced by researchers using transgenic models to study disease is the phenotypic variability that exists within a group or colony of animals. Significant pathological analyses thus often require large numbers of mice to perform. Many lines of transgenic mice harboring the gene for human amyloid precurso... |
2,323,563 | Dopamine systems in the forebrain. | The brain contains a number of distinct regions that share expression ofdopamine (DA) and its requisite biosynthetic machinery, but otherwise encompass a diverse array of features and functions. Across the vertebrate family, the olfactory bulb (OB) contains the major DA system in the forebrain. OB DA cells are primaril... |
2,323,564 | Hemangiopericytoma arising in the body of the lateral ventricle. | A 65-year-old woman presented with a very rare hemangiopericytoma in the body of the lateral ventricle.Magnetic resonance imaging demonstrated a homogeneously enhancing mass lesion occupying the bilateral medial portions of the body of the lateral ventricle. Cerebral angiography disclosed a vascular-rich tumor, fed mai... |
2,323,565 | Sex-specific modulation of cell proliferation by socially relevant stimuli in the adult green treefrog brain (Hyla cinerea). | Social experience plays an important role in regulating the neural, physiological and hormonal changes that accompany the expression of reproductive behavior in vertebrates. This suite of functions is sexually dimorphic, with different neural control areas preeminent in males and females. In anuran amphibians, social e... |
2,323,566 | Demonstration of cerebral venous variations in the region of the third ventricle on phase-sensitive imaging. | Susceptibility-weighted (SW) MR imaging has enabled noninvasive visualization of the cerebral veins and has shed light on the nature of venous architecture. For successful surgery of the third ventricle, understanding of the anatomy of the subependymal veins of the lateral ventricle and their relationships to the foram... |
2,323,567 | [Postsurgical WEBINO, a new form of this syndrome]. | A 20 year-old woman was submitted to resection of an ependymome of the fourth ventricle. After surgery the patient began to refer diplopia and oscillopsia. WEBINO syndrome (wall-eyed bilateral internuclear ophthalmoplegia), vertical nystagmus and skew deviation were diagnosed.</AbstractText>WEBINO syndrome is considere... |
2,323,568 | Solitary intra-ventricular brain metastasis from a breast carcinoma. | Prevalence of symptomatic central nervous system (CNS) metastases among patients with breast cancer ranges from 5% to 16%, although autoptic studies have reported prevalence rates of up to 30%. Solid brain tumours are the most common presentation in the CNS (85-95%), and they tend to arise at the grey-white matter junc... |
2,323,569 | Reptilian heart development and the molecular basis of cardiac chamber evolution. | The emergence of terrestrial life witnessed the need for more sophisticated circulatory systems. This has evolved in birds, mammals and crocodilians into complete septation of the heart into left and right sides, allowing separate pulmonary and systemic circulatory systems, a key requirement for the evolution of endoth... |
2,323,570 | Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats. | In some tissues, the injection of antibodies to the beta(1)-integrins leads to a reduction in interstitial fluid pressure, indicating an active role for the extracellular matrix in tissue pressure regulation. If perturbations of the matrix occur in the periventricular area of the brain, a comparable lowering of interst... |
2,323,571 | The subventricular zone is the developmental milestone of a 6-layered neocortex: comparisons in metatherian and eutherian mammals. | The major lineages of mammals (Eutheria, Metatheria, and Monotremata) diverged more than 100 million years ago and have undergone independent changes in the neocortex. We found that adult South American gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii) possess a significantly lower... |
2,323,572 | Posterior cerebral artery P1 segment at the stoma during endoscopic third ventriculostomy in adults. | A serious catastrophic complication of endoscopic third ventriculostomy (ETV) is basilar artery (BA) damage. Although the BA has been discussed as the cause of haemorrhage and even pseudoaneurysm, variations of the posterior cerebral artery proximal segment (P1) and its protrusion into the third ventricle floor have no... |
2,323,573 | [Regulation of resting intracellular Ca(2+) concentration of ventricular myocytes by beta(3)-adrenoceptor and its signaling pathway in rats with experimental heart failure]. | To observe the effect of beta(3)-adrenoceptor (AR) in regulating resting intracellular Ca(2+) concentration of the ventricular myocytes and investigate the signaling pathway in rats with experimental heart failure.</AbstractText>Rat models of experimental heart failure were established by ligation of the anterior desce... |
2,323,574 | Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia. | Schizophrenia is a neuropsychiatric disorder of a neurodevelopmental origin manifested symptomatically after puberty. Structural neuroimaging studies show that neuroanatomical aberrations occur before onset of symptoms, raising a question of whether schizophrenia can be prevented. Treatment with atypical antipsychotic ... |
2,323,575 | Regulation of cerebrospinal fluid production by caffeine consumption. | Caffeine is the most commonly consumed psycho-stimulant in the world. The effects of caffeine on the body have been extensively studied; however, its effect on the structure of the brain has not been investigated to date.</AbstractText>In the present study we found that the long-term consumption of caffeine can induce ... |
2,323,576 | Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. | Cohesin and condensin are similar, but distinct multi-subunit protein complexes that have well-described roles in sister chromatid cohesion and chromosome condensation, respectively. Recently it has emerged that cohesin, and proteins that regulate cohesin function have additional developmental roles. To further underst... |
2,323,577 | [ARTCEREB irrigation and perfusion solution for cerebrospinal surgery: pharmacological assessment using human astrocytes exposed to test solutions]. | ARTCEREB irrigation and perfusion solution (Artcereb) is a preparation intended for the irrigation and perfusion of the cerebral ventricles, and it is therefore important to evaluate the effects of Artcereb on brain cells. In vitro assessment of the effects of Artcereb in cell cultures of human fetal astrocytes was con... |
2,323,578 | MRI of secondary cervical syringomyelia in four cats. | This report describes the use of magnetic resonance imaging (MRI) to diagnose cervical syringomyelia in 4 cats. MRI revealed enlargement of the lateral ventricle in all the cats. Of the 4 cases, MRI revealed herniation of the cerebellum in 3 cats, an isolated fourth ventricle in 1 cat, severe hydrocephalus in 2 cats an... |
2,323,579 | Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. | Several magnetic resonance imaging (MRI) studies have identified structural abnormalities in association with bipolar disorder. The literature is, however, heterogeneous and there is remaining uncertainty about which brain areas are pivotal to the pathogenesis of the condition.</AbstractText>To identify, appraise and s... |
2,323,580 | Three-wall segment (TriSeg) model describing mechanics and hemodynamics of ventricular interaction. | A mathematical model (TriSeg model) of ventricular mechanics incorporating mechanical interaction of the left and right ventricular free walls and the interventricular septum is presented. Global left and right ventricular pump mechanics were related to representative myofiber mechanics in the three ventricular walls, ... |
2,323,581 | Water deprivation affects serotoninergic system and glycoprotein secretion in the sub-commissural organ of a desert rodent Meriones shawi. | Water deprivation is a stress that has been associated with activation of several endocrine systems, including circumventricular organs of the central nervous system. The sub-comissural organ (SCO), characterized by its glycoprotein secretion called Reissner's fiber has been suggested to play a role in the regulation o... |
2,323,582 | Failure of a Torkildsen shunt after functioning for 50 years. | Mechanical obstruction is a severe complication of ventricular catheter use. Its incidence was shown to be high in the 1960s and 1970s, with up to 41% of the catheters becoming obstructed within 10 years after surgery. The authors present what is to their knowledge the first reported case of a patient with failure of a... |
2,323,583 | Stem cell therapy for Parkinson's disease: a road map for a successful future. | Cell transplant therapy for Parkinson's disease (PD) has been in use for over 2 decades as an experimental treatment. Different cell types have been proposed as better therapeutic alternatives. However, source availability and therapeutic value of the transplants as compared to current pharmacological options have prec... |
2,323,584 | [Malignant lymphoma presented as left trigeminal neuralgia]. | A male, 60 years of age, presented with transient left facial pain located within all three divisions of the trigeminal nerve. Magnetic resonance imaging (MRI) revealed a swollen left trigeminal nerve with gadolinium enhancement. Following schwannoma diagnosis, the patient received Gamma Knife radiosurgery, which prove... |
2,323,585 | Quality of life in obstructive hydrocephalus: endoscopic third ventriculostomy compared to cerebrospinal fluid shunt. | In the current literature, there are essentially no comparisons of quality of life (QOL) outcome after endoscopic third ventriculostomy (ETV) and shunt in childhood hydrocephalus. Our objective was to compare QOL in children with obstructive hydrocephalus, treated with either ETV or shunt.</AbstractText>A cross-section... |
2,323,586 | Maternal antenatal complications and the risk of neonatal cerebral white matter damage and later cerebral palsy in children born at an extremely low gestational age. | In a 2002-2004 prospective cohort study of deliveries of infants at <28 weeks at 14 US centers, the authors sought the antecedents of white matter damage evident in newborn cranial ultrasound scans (ventriculomegaly and an echolucent lesion) and of cerebral palsy diagnoses at age 2 years. Of the 1,455 infants enroll... |
2,323,587 | A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus. | In mammals, the synchronized activity of cell autonomous clocks in the suprachiasmatic nuclei (SCN) enables this structure to function as the master circadian clock, coordinating daily rhythms in physiology and behavior. However, the dominance of this clock has been challenged by the observations that metabolic duress ... |
2,323,588 | Inappropriate ICD discharges due to noise oversensing as the first sign of repetitive perforations of the right ventricular lead. | Acute lead perforation is one of the major complications associated with implantable cardioverter defibrillator (ICD) implantation. We describe a case with repetitive inappropriate ICD discharges due to noise oversensing as the first sign of lead perforation. |
2,323,589 | Intraventricular textiloma with granuloma formation following third ventricle colloid cyst resection - a case report. | Despite precautions, cotton and gauze pads used for dissection or to achieve haemostasis during neurosurgical procedures can inadvertently be left behind and result in clinically symptomatic or asymptomatic and radiologically apparent mass lesion, sometimes referred to as "textilomas" or "gossypibomas", often mimicking... |
2,323,590 | Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. | Down syndrome (DS) is the most common cause of mental retardation. Although structural and neurogenic abnormalities have been shown in the brains of DS patients, the molecular etiology is still unknown. To define it, we have performed structural and histological examinations of the brains of Ts1Cje and Ts2Cje, 2 mouse ... |
2,323,591 | Uncomplicated neurosurgical resection of a malignant glioneuronal tumour under haemostatic cover of rFVIIa in a severe haemophilia patient with a high-titre inhibitor: a case report and literature review of rFVIIa use in major surgeries. | The development of inhibitors following factor VIII replacement therapy is a serious complication in severe inherited haemophilia. Whereas significant experience, notably in orthopaedic surgery, is now obtained with the use of bypassing agents in haemophilia with high-titre inhibitor, new surgical challenges might occu... |
2,323,592 | Distribution of ryanodine receptors in rat ventricular myocytes. | Ryanodine receptors (RyRs) are the major ion channels in the sarcoplasmic reticulum responsible for Ca2+ release in muscle cells. Localization of RyRs is therefore critical to our understanding of Ca2+ cycling and Ca2+-dependent processes within ventricular cells. Recently, RyRs were reportedly found in non-classical l... |
2,323,593 | Endoscopic diagnosis and treatment of far distal obstructive hydrocephalus. | Obstruction of the CSF circulation distal to the fourth ventricle is a rare cause of noncommunicating hydrocephalus. Endoscopic third ventriculostomy (ETV) represents one of the treatment options, but reports of results are rare.</AbstractText>Between March 1997 and June 2008, 20 ETVs in 20 patients (mean 32.4 years, r... |
2,323,594 | Atypical choroid plexus papilloma in an adult. | We present an extremely rare case of the atypical choroid plexus papilloma in an adult which developed at the trigone of right lateral ventricle. A 62-year-old woman presented with the history of intermittent and gradually progressive headache and left side hemiparesis for 6 months. The brain magnetic resonance image s... |
2,323,595 | Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation. | The p(21) activated kinase-1 (Pak1) is a serine-threonine protein kinase directly activated by Cdc42 and Rac1. In cardiac myocytes, Pak1 activation leads to dephosphorylation of cTnI and C-protein through upregulation of phosphatase-2A (PP2A). Pak1 activity is directly correlated with its autophosphorylation, which occ... |
2,323,596 | Neuropsychological changes after endoscopic third ventriculostomy for long-standing overt ventriculomegaly in adults. Case report. | A 39-year-old woman presented with long-standing overt ventriculomegaly in adults (LOVA) manifesting as gradually worsening headache. Past history included treatment for myeloschisis at birth. Intelligence quotient (IQ) was 115 and preoperative psychological assessment using the Repeatable Battery for the Assessment of... |
2,323,597 | MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. | Several recent reports have suggested that microRNAs (miRNAs) might play critical roles in acute myocardial infarction (AMI). However, the miRNA expression signature in the early phase of AMI has not been identified. In this study, the miRNA expression signature was investigated in rat hearts 6 h after AMI. Compared wi... |
2,323,598 | Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. | The retinoblastoma tumor-suppressor protein, pRb, is a member of the pocket protein family that includes p107 and p130. These proteins have well-defined roles in regulating entry into and exit from the cell cycle and also have cell cycle-independent roles in facilitating differentiation. Here we investigate the overlap... |
2,323,599 | Effects of the LHRH antagonist Cetrorelix on affective and cognitive functions in rats. | The decapeptide LHRH antagonist, Cetrorelix, inhibits gonadotropin and sex-steroid secretion. Cetrorelix is used for IVF-ET procedures and for the treatment of benign prostatic hyperplasia, endometriosis and leiomyomas. However little is known about the effects of Cetrorelix on brain functions. Previously we have teste... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.