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2,323,700 | [Secondary hypopituitarism due to hypothalamic metastasis from small cell lung cancer]. | Parasellar and hypothalamic metastases are uncommon. Their principal clinical manifestation is diabetes insipidus. Associated hypopituitarism is very rare. We report the case of a 54-year-old man with small cell lung cancer and hypopituitarism. A brain magnetic resonance imaging scan revealed a mass in the anterior reg... |
2,323,701 | Brain abnormalities in Sjogren syndrome with recurrent CNS manifestations: association with neuromyelitis optica. | Optic neuritis or longitudinally extensive myelitis in Sjogren syndrome (SS) suggests a neuromyelitis optica spectrum disorder (NMOSD). However, brain abnormalities of SS remain to be elucidated for the association with neuromyelitis optica (NMO).</AbstractText>Twelve primary SS patients (all women, 42 +/- 13.2 years) ... |
2,323,702 | Intraventricular location of metastatic breast carcinoma: a case report. | Intraventricular neoplasms are uncommon central nervous system lesions that account for only 10% of all neoplasms and are unusual location of metastatic breast cancer. A 73-year-old woman with a medical history of breast carcinoma without any signs of metastatic lesions in the liver, lungs or bones and with an intraven... |
2,323,703 | Free water elimination and mapping from diffusion MRI. | Relating brain tissue properties to diffusion tensor imaging (DTI) is limited when an image voxel contains partial volume of brain tissue with free water, such as cerebrospinal fluid or edema, rendering the DTI indices no longer useful for describing the underlying tissue properties. We propose here a method for separa... |
2,323,704 | Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression. | The stage-dependent organization of the cardiomyocytes during formation of the different layers of the developing ventricular wall is critical for the establishment of a functional heart, but the instructive signals involved are still poorly known. We have addressed the potential role of Wnt-11 in the control of early ... |
2,323,705 | [Schizophrenia as a neurological condition caused by a failure in the lateralisation of the brain: macro and microscopic observations]. | Schizophrenia is a neurodevelopmentally defined condition. Some of its salient symptomatology refers to language abnormalities that resemble an aphasic disorder. Recent studies suggest that brain structures that define language functions may be abnormally lateralized in schizophrenic patients.</AbstractText>To review t... |
2,323,706 | Choroid plexus papillomas in two siblings: case report. | Choroid plexus papilloma (CPP) is a rare, benign epithelial brain tumor of the nervous system seen particularly in infants. Familial cases are extremely uncommon. Some other form of malignant tumors was noted in the relatives of patients with CPPs, and some genetic defects regarding this coincidence were reported in th... |
2,323,707 | Diffuse subcortical band heterotopia, periodic limb movements during sleep and a novel "de novo" mutation in the DCX gene. | Mutations of the DCX gene (Xp22.3) cause X-linked lissencephaly in males and double cortex syndrome (DCS) or subcortical band heterotopia (SBH) in females. SBH is characterized by bilateral bands of grey matter interposed in the white matter between the cortex and the lateral ventricles. The main clinical manifestation... |
2,323,708 | Differential expressions of aquaporin subtypes in astroglia in the hippocampus of chronic epileptic rats. | In order to elucidate the roles of aquaporins (AQPs) in astroglial responses, we investigated AQP expressions in the experimental epileptic hippocampus. In control animals, AQP1 protein expression was restricted to the ventricular-facing surface of the choroid plexus. AQP4 was expressed in astrocyte foot processes near... |
2,323,709 | Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. | Cell proliferation of neural progenitors in the subventricular zone (SVZ) of Parkinson disease (PD) patients and animal models is decreased. It was previously demonstrated that the neurotransmitter dopamine modulates cell proliferation in the embryonic brain. The aim of the present study was to analyze whether oral tre... |
2,323,710 | [Progress in the study of brain tumor stem cells as treatment targets]. | The study of cancer stem cells (CSCs) is on the cutting edge of cancer research. Following the discovery of neural stem cells (NSCs), extensive studies on their characteristics led to the discovery of cancer stem cells (CSCs) in brain tumors: these cells are termed brain tumor stem cells (BTSCs). The study of NSCs prov... |
2,323,711 | Colloid cysts of the third ventricle. Endoscopic and open microsurgical management. | The endoscopic approach to colloid cysts of the third ventricle is receiving increasing interest. However, its effectiveness is a matter of discussion. The aim of the study was to present direct and long-term outcome after endoscopy of colloid cyst vs microsurgery.</AbstractText>Medical records of 23 patients with coll... |
2,323,712 | The behavioral change of locomotor activity in a kaolin-induced hydrocephalus rat model: evaluation of the effect on the dopaminergic system with progressive ventricle dilatation. | Hydrocephalus is a pathological enlargement of the cerebral ventricle that results from an obstruction of the space containing cerebrospinal fluid (CSF) in the brain. Motor abnormalities, such as abnormal gait and posture, are frequently seen in patients with hydrocephalus. The present study was designed to investigate... |
2,323,713 | MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters. | For 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to exert neurotoxicity on dopaminergic neurons, 1-methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, must be taken up into the dopaminergic neuron via the dopamine transporter (DAT). Previous reports have shown that MPTP also causes neuroblast apoptosis in th... |
2,323,714 | Adult neurogenesis and the olfactory system. | Though initially described in the early 1960s, it is only within the past decade that the concept of continuing adult neurogenesis has gained widespread acceptance. Neuroblasts from the subventricular zone (SVZ) migrate along the rostral migratory stream (RMS) into the olfactory bulb, where they differentiate into inte... |
2,323,715 | Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice. | Interleukin-1beta (IL-1beta) may play a central role in the inflammatory response following traumatic brain injury (TBI). We subjected 91 mice to controlled cortical impact (CCI) brain injury or sham injury. Beginning 5 min post-injury, the IL-1beta neutralizing antibody IgG2a/k (1.5 microg/mL) or control antibody was ... |
2,323,716 | Investigation of ventricular cerebrospinal fluid flow phase differences between the foramina of Monro and the aqueduct of Sylvius. | In this paper, phase contrast magnetic resonance flow measurements of the foramina of Monro and the aqueduct of Sylvius of seven healthy volunteers are presented. Peak volume flow rates are of the order of 150 mm3/s for the aqueduct of Sylvius and for the foramina of Monro. The temporal shift between these volume flows... |
2,323,717 | Familial congenital unilateral cerebral ventriculomegaly: Delineation of a distinct genetic disorder. | We identified two female siblings, derived from healthy first cousin parents, with congenital unilateral cerebral ventriculomegaly detected prenatally. Patient 1 underwent ventriculoperitoneal shunt operation at 1 week old, while Patient 2 was followed without surgical intervention. Both patients presented with mild de... |
2,323,718 | Trans-cerebellomedullary fissure approach with special reference to lateral route. | The trans-cerebellomedullary fissure (CMF) approach provides good exposure of the fourth ventricle without splitting the inferior vermis. The popularly utilized trans-CMF approach is performed in the midline suboccipital approach. However, the trans-CMF approach actually has two routes: medial and lateral. The lateral ... |
2,323,719 | Single-stage treatment of spina bifida with hydrocephalus based on a prediction rule derived from preoperative cranial ultrasound. | It was the aim of this study to report a prospective study of 110 spina bifida patients with hydrocephalus treated by simultaneous ventriculoperitoneal (VP) shunt and repair of the meningomyelocele.</AbstractText>Between January 2005 and February 2008, 264 patients with spina bifida were admitted to the author's depart... |
2,323,720 | Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging. | To establish human retinoblastoma (RB) animal models that allow sensitive, noninvasive and continuous monitoring of tumor growth and metastasis in vivo.</AbstractText>The human RB tumor cell lines HXO-Rb44 and Y79 were engineered to express a fusion reporter gene allowing for bioluminescence and fluorescence imaging. I... |
2,323,721 | Dermoid tumor with diastematobulbia. | Dermoid tumors are rare congenital lesions and account for 0.2% to 1.8% of all intracranial tumors. Dermoid tumor with diastematobulbia is very rare.</AbstractText>We report a dermoid tumor in an adult female with an unusual location and morphology. The lesion had 2 major components with different material within the c... |
2,323,722 | Cytoplasmic gelsolin increases mitochondrial activity and reduces Abeta burden in a mouse model of Alzheimer's disease. | Accumulation of amyloid-beta (Abeta) peptides is thought to be a critical event in the pathology of Alzheimer's disease (AD), because they induce multiple neurotoxic effects, including mitochondrial dysfunction and apoptotic cell death. Therefore the reduction of Abeta is considered a primary therapeutic target. Gelsol... |
2,323,723 | Synaptic responses in cochlear nucleus neurons evoked by activation of the olivocochlear system. | The action of olivocochlear collaterals to the cochlear nucleus is not fully established. Synaptic ultrastructure suggests an excitatory role. Extracellular recordings show spikes evoked by electrical stimulation of olivocochlear axons, but these spikes in the cochlear nucleus may be antidromic (activation of output ax... |
2,323,724 | Effect of interleukin 6 deficiency on the expression of Bcl-2 and Bax in the murine heart. | Interleukin 6 (IL-6) is a pleiotropic cytokine that is highly expressed in response to ischemia and reperfusion. It has dichotomous roles in the heart, functioning both as an inflammatory mediator as well as a protective agent. The aim of this study was to evaluate the effect of IL-6 deficiency on the expression of apo... |
2,323,725 | Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice. | Chronic stressors and inflammatory immune activation may contribute to pathophysiological alterations associated with both major depression and cardiovascular disease. The present study, conducted in mice, assessed whether a chronic stressor of moderate severity that induced an anhedonic effect, when coupled with a bac... |
2,323,726 | Pneumocephalus secondary to removal of an osteoma from the paranasal sinuses of a horse. | A 2-year-old Quarter Horse was evaluated because of a progressive left-sided facial deformity and unilateral nasal and ocular discharge.</AbstractText>Physical examination revealed convexity of the left frontonasal region, left-sided nasal and ocular discharge, and decreased air flow through the left nares. Radiography... |
2,323,727 | Oxidative stress damage and oxidative stress responses in the choroid plexus in Alzheimer's disease. | Choroid plexus homogenates from 27 cases with Alzheimer disease-related pathology (AD), stages I/0 (n = 5), III-IV/0-B (n = 15) and V-VI/B-C (n = 7) and 3 age-matched controls (no clinical symptoms, no neuropathological lesions) were processed for gel electrophoresis and western blotting for oxidation markers carboxyme... |
2,323,728 | Cognitive impairment risk: white matter hyperintensity progression matters. | To determine whether white matter hyperintensity (WMH) progression rate is a better predictor of cognitive impairment risk than baseline WMH volume in healthy elderly individuals.</AbstractText>Ninety-eight cognitively intact elderly subjects were followed in the Oregon Brain Aging Study. Forty-nine had at least 3 brai... |
2,323,729 | Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships. | To localize susceptibility genes for alterations in brain structure associated with risk of stroke and dementia. We conducted genomewide linkage analyses for magnetic resonance imaging (MRI) measures of brain atrophy, ventricular, and subcortical white matter hyperintensity (leukoaraiosis) in 689 non-Hispanic white (67... |
2,323,730 | Investigating the depth electrode-brain interface in deep brain stimulation using finite element models with graded complexity in structure and solution. | Deep brain stimulation (DBS) is an increasingly used surgical therapy for a range of neurological disorders involving the long-term electrical stimulation of various regions of the human brain in a disorder specific manner. Despite being used for the last 20 years, the underlying mechanisms are still not known, and dis... |
2,323,731 | Involvement of the intermediate nucleus of the lateral septal area on angiotensin II-induced dipsogenic and pressor responses. | Previous studies have shown that different parts of the septal area may have opposite roles in the control of water intake and cardiovascular responses. In the present study we investigated the effects of electrolytic lesions of the intermediate nucleus of the lateral septal area (LSI) on cardiovascular and dipsogenic ... |
2,323,732 | [Endoscopic therapy for obstructive hydrocephalus caused by cysts in the pathway of CSF circulation]. | To explore the process and technique of neuroendoscopic operation to treat obstructive hydrocephalus caused by cysts located in the pathway of CSF circulation.</AbstractText>The cine MRI examinations and endoscopic operations were taken to treat 30 cases with obstructive hydrocephalus. Among all the cases, there are 11... |
2,323,733 | Strain differences of cerebral ventricles in mice: can the MRL/MpJ mouse be a model for hydrocephalus? | Hydrocephalus is an intractable disease characterized by the excessive accumulation of cerebrospinal fluid (CSF) in the cerebral ventricles. There are many cases in both human and animals; however, the cause and mechanism of it's development is not clearly understood. In this study, differences of cerebral ventricles i... |
2,323,734 | The Golden Hour: care of the LBW infant during the first hour of life one unit's experience. | Care practices during the first hour of life, the Golden Hour, can have a significant impact on outcomes of low birth weight infants. Although the latest edition of the Neonatal Resuscitation Program added guidelines for preterm infants, additional care is often indicated. Complications that could potentially be impact... |
2,323,735 | The role of b-type natriuretic peptide in heart failure management. | Heart failure is a complex clinical syndrome that manifests itself with signs and symptoms which are neither sensitive nor specific for the diagnosis of heart failure. Natriuretic peptides and in particular b-type natriuretic peptide (and nt-proBNP) are widely used in clinical practice around the world as a maker of he... |
2,323,736 | Rosette-forming glioneuronal tumour of the fourth ventricle with previous intratumoural haemorrhage: case report and review of the literature. | The case is reported of a rosette-forming glioneuronal tumour of the fourth ventricle (RGTFV) in a 27-year-old male. Symptoms included headache, severe vomiting and clumsy walking that had progressively worsened over 14 days. Computed tomography and magnetic resonance imaging indicated a 3.0 x 2.5 x 2.0 cm solid-cystic... |
2,323,737 | Cerebellar loss and brain-stem atrophy associated with neonatal alloimmune thrombocytopenia in a discordant twin. | Neonatal alloimmune thrombocytopenia (NAIT) is due to an immune-mediated maternal-fetal platelet antigen incompatibility. Central nervous system abnormalities have been reported in infants with NAIT and include intracranial hemorrhage, ventriculomegaly, porencephalic cysts, neuronal migrational disorders, and, rarely, ... |
2,323,738 | Antenatal treatment in two Dutch families with pyridoxine-dependent seizures. | Incidental reports suggest that antenatal treatment of pyridoxine dependent seizures (PDS) may improve neurodevelopmental outcome of affected patients. Two families with PDS are reported, both with two affected siblings. Antenatal treatment with pyridoxine was instituted during the second pregnancy in each family (50 a... |
2,323,739 | Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. | Drugs that interfere with cannabinoid CB1 transmission suppress food-motivated behaviors and may be useful as appetite suppressants, but there is uncertainty about the locus of action for the feeding-suppression effects of these drugs.</AbstractText>The present work was conducted to determine if two drugs that interfer... |
2,323,740 | Supratentorial craniotomy complicated by an homolateral remote cerebellar hemorrhage and a controlateral perisylvian infarction: case report. | The authors present the case of a 49-year-old male patient with a right remote cerebellar hemorrhage and left perisylvian venous infarction complicating a right supratentorial craniotomy for temporal meningomia resection. These two events may result from a functional stenosis (due to perioperative brainstem sag) of the... |
2,323,741 | Endoscopic third ventriculostomy: predicting outcome with phase-contrast MR imaging. | To determine whether phase-contrast magnetic resonance (MR) imaging measurements of preoperative cerebral blood and cerebrospinal fluid (CSF) hydrodynamics can be used as a biomarker of response to endoscopic third ventriculostomy (ETV).</AbstractText>Approval from the local research ethics committee and written inform... |
2,323,742 | Effects of dexamethasone on the expression of beta(1)-, beta (2)- and beta (3)-adrenoceptor mRNAs in skeletal and left ventricle muscles in rats. | Glucocorticoids are known to increase the density and mRNA levels of beta-adrenoceptors (beta-AR) via the glucocorticoid receptor (GR) in many tissues. However, the effects of these changes in the skeletal and cardiac muscles remain relatively unknown. We have investigated the effects of dexamethasone on the expression... |
2,323,743 | Rosette-forming glioneuronal tumor: report of an unusual case with intraventricular dissemination. | A rosette-forming glioneuronal tumor (RGNT) was encountered in a 16-year-old Chinese girl. She experienced seizures with loss of consciousness for 1 month prior to diagnosis. A brain MRI revealed multifocal masses occupying all of the ventricular system associated with marked hydrocephalus. A biopsy was performed on th... |
2,323,744 | Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice. | Stress and alcohol abuse are co-related. Acute alcohol is anxiolytic and stress is cited as a factor in relapse to alcohol use. A primary mediator of the stress response is the neuropeptide corticotropin-releasing factor (CRF). The CRF family of endogenous ligands includes urocortin 3 (Ucn 3), which binds selectively t... |
2,323,745 | Enhanced hypothalamic glucose sensing in obesity: alteration of redox signaling. | Recent data demonstrated that glucose sensing in different tissues is initiated by an intracellular redox signaling pathway in physiological conditions. However, the relevance of such a mechanism in metabolic disease is not known. The aim of the present study was to determine whether brain glucose hypersensitivity pres... |
2,323,746 | [Neurological symptoms in patient with focal segmental glomerulosclerosis treated with cyclosporin A--case report]. | Cyclosporin A using in treatment glomerulonephritis can cause neurological side effects.</AbstractText>Nephrotic syndrome (NS) with microscopic hematuria was recognized in a boy in the age of 9.7 years. In kidney biopsy focal and segmental glomerulosclerosis was found. Remission was obtained on oral prednisone (60 mg/2... |
2,323,747 | Paradoxical immune reconstitution inflammatory syndrome associated with previous Cryptococcus neoformans infection in an HIV-positive patient requiring neurosurgical intervention. | Immune reconstitution inflammatory syndrome (IRIS) in HIV-1-infected patients is associated with an exaggerated inflammatory response against an opportunistic infection during highly active antiretroviral therapy. The only review on IRIS associated with Criptococcus neoformans reported 21 episodes including lymphadenit... |
2,323,748 | [Severe intracranial hypotension in an adolescent with Marfan syndrome. Case report].<Pagination><StartPage>181</StartPage><EndPage>184</EndPage><MedlinePgn>181-4</MedlinePgn></Pagination><Abstract><AbstractText>Spontaneous intracranial hypotension is a rare complication of connective tissue disorders. One of them is M... | Spontaneous intracranial hypotension is a rare complication of connective tissue disorders. One of them is Marfan syndrome. It predisposes the patient to meningeal diverticula. Possibly after minor unrecognised head trauma or secondary to Valsalva manoeuvre cerebrospinal fluid leak from meningeal diverticula can happen... |
2,323,749 | Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC). | The cardiac interstitium is a unique and adaptable extracellular matrix (ECM) that provides a milieu in which myocytes, fibroblasts, and endothelial cells communicate and function. The composition of the ECM in the heart includes structural proteins such as fibrillar collagens and matricellular proteins that modulate c... |
2,323,750 | Influence of the metabolic syndrome versus the sum of its individual components on left ventricular geometry in young adults (from the Bogalusa Heart Study). | Current preventive cardiology guidelines strongly recommend identification of metabolic syndrome (MS), a constellation of cardiovascular risk factors, in clinical practice. These MS risk factors, individually or in a cluster, adversely alter left ventricular (LV) geometry. However, it is still unclear whether MS predic... |
2,323,751 | Expression of HNF4alpha in the human and rat choroid plexus: implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier. | The choroid plexus consists of highly differentiated epithelium and functions as a barrier at the interface of the blood-cerebrospinal-fluid (CSF). This tissue may therefore determine the bioavailability and transport of drugs to the brain. Little is known about the expression of drug and xenobiotic metabolizing enzyme... |
2,323,752 | On old and new comparative neurological sinners: the evolutionary importance of the membranous parts of the actinopterygian forebrain and their sites of attachment. | The forebrain of actinopterygian fishes differs from that of other vertebrates in that it consists of a pair of solid lobes. Lateral ventricles surrounded by nervous tissue are entirely lacking. This peculiar configuration of the actinopterygian forebrain results from an outward bending or eversion of its lateral walls... |
2,323,753 | Blood vessels form a migratory scaffold in the rostral migratory stream. | In adult mice, new neurons born in the subventricular zone (SVZ), lining the lateral ventricles, migrate tangentially into the olfactory bulb along a well-delineated path, the rostral migratory stream (RMS). Neuroblasts in the RMS migrate tangentially in chains, without a recognized migratory scaffold. Here we quantita... |
2,323,754 | Intraventricular gliosarcoma: unusual location of an uncommon tumor. | Gliosarcomas are uncommon variants of glioblastoma bearing the histological hallmark of two distinct tumor components (high grade glial and sarcomatous). They share similarities with glioblastomas as far as clinico-epidemiological and prognostic factors are concerned. They are commonly cortically-surfacing lesions occu... |
2,323,755 | [Symptomatic xanthogranuloma of the lateral ventricle]. | Xanthogranulomas of the choroid plexus is a benign tumour of uncertain etiology, usually asymptomatic. We report a case of symptomatic xanthogranuloma of the left lateral ventricle with edema in adjacent white matter, in a 62-year-old man with seizures. |
2,323,756 | [Isolated mesencephalic stroke related to a ruptured intracranial dermoid cyst]. | Dermoids cysts are embrionary benign lesions that comprise approximately 0.04-0.25% of all intracranial tumors. Occasionally they break and spread their content into subarachnoid space and/or lateral ventricles causing several acute or delayed symptoms. Debut of this type of tumor as acute stroke is poorly reflected in... |
2,323,757 | RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats. | To test the role of the Beclin 1-dependent autophagy pathway in brain damage during cerebral ischemia.</AbstractText>Focal cerebral ischemia was established in rats using a middle cerebral artery occlusion (MCAO) model. A lentiviral vector-associated RNA interference (RNAi) system was stereotaxically injected into the ... |
2,323,758 | Endoscopic intraventricular biopsy of infundibular Langerhans cell histiocytosis: case report. | Surgical biopsy of isolated infundibular lesions is indicated in patients who are symptomatic or whose imaging suggests a treatable lesion. Early therapy can prevent irreversible neurological or endocrinological damage and, potentially, metastasis. These considerations justify the small risk associated with surgery.</A... |
2,323,759 | [Role of Ommaya reservoir in the management of neonates with post-hemorrhagic hydrocephalus]. | Intra-ventricular hemorrhage (IVH) is one of the most serious complications of preterm infants. Significant numbers of the surviving infants with severe IVH go on to develop post-hemorrhagic hydrocephalus (PHH). The management of PHH remains a very challenging problem for both neonatologists and pediatric neurosurgeons... |
2,323,760 | [Multicenter survey for incidence of intraventricular hemorrhage in premature infants in seven big cities of China]. | Sponsored by the Subspecialty Group of Neonatology of Pediatric Society, Chinese Medical Association, more than ten large hospitals joined the 20-month multicenter investigation for Brain Injuries in Premature Infants in China. This paper presents the results of the incidence of intraventricular hemorrhage (IVH) in pre... |
2,323,761 | Cognitive reserve moderates the negative effect of brain atrophy on cognitive efficiency in multiple sclerosis. | According to the cognitive reserve hypothesis, neuropsychological expression of brain disease is attenuated among persons with higher education or premorbid intelligence. The current research examined cognitive reserve in multiple sclerosis (MS) by investigating whether the negative effect of brain atrophy on informati... |
2,323,762 | The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. | Morphometric endophenotypes which have been proposed for psychotic disorders include lateral ventricular enlargement and hippocampal volume reductions. Genetic epidemiological studies support an overlap between schizophrenia and bipolar disorder, and COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes have been implicated in the ... |
2,323,763 | The relationship between surface temperature, tissue temperature, microbubble formation, and steam pops. | It has been proposed that microbubble (MB) monitoring can be used to safely titrate radiofrequency (RF) power. However, MB formation has been found to be an insensitive indicator of tissue temperature during RF delivery. We hypothesized that MB formation corresponds to surface-not tissue--temperature, and therefore wou... |
2,323,764 | Local regional stimulation of single isolated ventricular myocytes using microfluidics. | The regional manipulation of the microenvironment surrounding single adult cardiac myocytes in a microfluidic structure is described. The flow rates of laminar streams were adjusted such that the fluid interface between an injection flow and a perfusion flow was manipulated laterally to stimulate regions of the cell su... |
2,323,765 | Prenatal diagnosis of Chiari malformation with syringomyelia in the second trimester. | Routine anatomic ultrasound performed in the second trimester has a detection rate of approximately 70-90% for fetal congenital abnormalities (Nyberg and Souter, J Ultrasound Med 2001;6:655-674). The central nervous system abnormalities are one of the most common ones detected. Chiari malformation is among the CNS abno... |
2,323,766 | Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. | Choroid plexuses (ChPs) are vascularized secretory organs involved in the regulation of brain homeostasis, and function as the blood-cerebrospinal fluid (CSF) barrier. Despite their crucial roles, there is limited understanding of the regulatory mechanism driving ChP development. Sonic hedgehog (Shh), a secreted signal... |
2,323,767 | Consistent neuroanatomical age-related volume differences across multiple samples. | Magnetic resonance imaging (MRI) is the principal method for studying structural age-related brain changes in vivo. However, previous research has yielded inconsistent results, precluding understanding of structural changes of the aging brain. This inconsistency is due to methodological differences and/or different agi... |
2,323,768 | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine. | Pharmacoresistance is a common problem hindering treatment of epilepsy. A possible cause for this resistance is the overexpression of efflux drug transporters, e.g. P-glycoprotein (P-gp), which may decrease extracellular antiepileptic drugs levels in brains of intractable epilepsy patients. Another transmembrane drug t... |
2,323,769 | Brain injury expands the numbers of neural stem cells and progenitors in the SVZ by enhancing their responsiveness to EGF. | There is an increase in the numbers of neural precursors in the SVZ (subventricular zone) after moderate ischaemic injuries, but the extent of stem cell expansion and the resultant cell regeneration is modest. Therefore our studies have focused on understanding the signals that regulate these processes towards achievin... |
2,323,770 | Increased neuronal proliferation in the dentate gyrus of aged rats following neural stem cell implantation. | It is now well accepted that the brain is able to generate newborn neurons from a population of resident multipotential neural stem cells (NSCs) located in two discrete regions of the brain. The capacity for neurogenesis appears to diminish over the lifespan of an organism. Methods to potentiate the proliferation of ne... |
2,323,771 | Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells. | We investigated the effects of bone marrow-derived mesenchymal stem cells (MSCs) transplantation on the recovery of neurological functions in rat's MCAO (middle cerebral artery occlusion) model and its mechanism. MSCs were isolated from bone marrow of male Sprague Dawley (SD) rats. Female adult SD rats were randomly as... |
2,323,772 | Analysis of baroreflex sensitivity during undulation pump ventricular assist device support.<Pagination><StartPage>561</StartPage><EndPage>565</EndPage><MedlinePgn>561-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1525-1594.2009.00738.x</ELocationID><Abstract><AbstractText>The aim of this ... | The aim of this study was to examine the baroreflex sensitivity (BRS), which involves the autonomic nervous system, in a goat with a chronically implanted undulation pump ventricular assist device (UPVAD). The UPVAD involved transforming the rotation of a brushless DC motor into an undulating motion by a disc attached ... |
2,323,773 | Dandy-Walker variant associated with bipolar affective disorder. | The Dandy-Walker malformation is a congenital brain malformation, typically involving the fourth ventricle and the cerebellum. To date, the Dandy-Walker syndrome has not been described in association with bipolar disorder type I mania, and therefore we briefly report the case of a Dandy-Walker variant associated with a... |
2,323,774 | Intracranial (structural) changes in obsessive- compulsive disorder: A computerized tomography scan study. | To assess intracranial structural changes in obsessive-compulsive disorder (OCD) with CT scan.</AbstractText>Thirty patients of OCD between 21 and 40 years of age and fulfilling various inclusion and exclusion criteria were compared with control group. CT scans of all the patients and controls were taken and compared w... |
2,323,775 | Gap junctions are involved in cell migration in the early postnatal subventricular zone. | The massive migration of neuroblasts and young neurons through the anterior extension of the postnatal subventricular zone (SVZ), known as the rostral migratory stream (RMS) is still poorly understood on its molecular basis. In this work, we investigated the involvement of gap junctional communication (GJC) in the robu... |
2,323,776 | Cavum veli interpositi cyst: prenatal diagnosis and postnatal outcome. | The cavum veli interpositi (CVI) is a space within the double-layered tela choroidea of the third ventricle. Occasionally, this space is fluid-filled and sonographically visible as an interhemispheric anechoic cyst. Because of its rarity, the incidence of CVI cyst is undetermined and the outcome of affected individuals... |
2,323,777 | Requirement of central ghrelin signaling for alcohol reward. | The stomach-derived hormone ghrelin interacts with key CNS circuits regulating energy balance and body weight. Here we provide evidence that the central ghrelin signaling system is required for alcohol reward. Central ghrelin administration (to brain ventricles or to tegmental areas involved in reward) increased alcoho... |
2,323,778 | Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer. | In spite of recent advancements in the treatment of pulmonary hypertension, successful control has yet to be accomplished. The abundant presence of angiotensin-converting enzyme 2 (ACE2) in the lungs and its impressive effect in the prevention of acute lung injury led us to test the hypothesis that pulmonary overexpres... |
2,323,779 | Cerebral oxygen saturation and extraction in preterm infants with transient periventricular echodensities. | Our aim was to determine regional cerebral tissue oxygen saturation and fractional tissue oxygen extraction in preterm infants with transient periventricular echodensities. We hypothesized that as a result of reduced cerebral perfusion, regional cerebral tissue oxygen saturation will be lower and fractional tissue oxyg... |
2,323,780 | [Trabeculae and intertrabecular spaces of the heart interventricular septum: anatomical structure and development]. | The review presents traditional and new concepts on the development of the trabeculae carneae and intertrabecular spaces (ITS) in the heart ventricles. Myocardial trabeculation preceeds the ventricular septation and at the same time underlies the formation of the interventricular septum. Trabeculae carneae seem to gene... |
2,323,781 | There is no transmural heterogeneity in an index of action potential duration in the canine left ventricle. | Transmural heterogeneity in ventricular repolarization demonstrated in vitro has been difficult to confirm in vivo. Whether this discrepancy reflects a physiological phenomenon or a methodological problem remains a vivid matter of debate despite a plethora of experimental work. Therefore, we have measured the relevant ... |
2,323,782 | Distribution of tryptophan hydroxylase-immunoreactive neurons in the brainstem and diencephalon of the pigeon (Columba livia). | The distribution of tryptophan hydroxylase (TPH)-containing perikarya and processes in the brainstem and diencephalon of the pigeon (Columba livia) were investigated using single-labeling chromogenic and double-labeling fluorescence immunohistochemical methods for TPH and 5-HT. TPH-immunoreactive (TPH-ir) perikarya wer... |
2,323,783 | Association of Chiari malformation type I and tethered cord syndrome: preliminary results of sectioning filum terminale. | The pathogenesis of CM-I is incompletely understood. We describe an association of CM-I and TCS that occurs in a subset of patients with normal size of the PCF.</AbstractText>The prevalence of TCS was determined in a consecutively accrued cohort of 2987 patients with CM-I and 289 patients with low-lying cerebellar tons... |
2,323,784 | Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labelling reveals spatially restricted neurogenic niches in the olfactory bulb. | The subventricular zone (SVZ) of the lateral ventricles is the major neurogenic region in the adult mammalian brain, harbouring neural stem cells within defined niches. The identity of these stem cells and the factors regulating their fate are poorly understood. We have genetically mapped a population of Nestin-express... |
2,323,785 | Intracerebroventricular administration of drugs. | Intracerebroventricular drug administration is a method that bypasses the blood-brain barrier and other mechanisms that limit drug distribution into the brain, allowing high drug concentrations to enter the central compartment. Instillation of drugs directly into the ventricles of the brain must be done carefully and w... |
2,323,786 | Cine cardiac imaging using black-blood steady-state free precession (BB-SSFP) at 3T. | To propose a new black-blood (BB) pulse sequence that provides BB cine cardiac images with high blood-myocardium contrast. The proposed technique is based on the conventional steady-state free precession (SSFP) sequence.</AbstractText>Numerical simulations of the Bloch equation were conducted to compare the resulting s... |
2,323,787 | Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron. | To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2(*) technique for global and segmental measurement of iron overload in thalassemia patients.</AbstractText>Multiecho T2(*) sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; ... |
2,323,788 | Intraventricular and subarachnoid basal cisterns neurocysticercosis: a comparative study between traditional treatment versus neuroendoscopic surgery. | The purpose of this study was to evaluate the efficacy of traditional treatment and minimal invasive flexible endoscopy surgery (MIFNES) in the treatment of intraventricular and subarachnoid basal cisterns neurocysticercosis (NCC).</AbstractText>This was an observational comparative study of two independent series with... |
2,323,789 | Modeling the instantaneous pressure-volume relation of the left ventricle: a comparison of six models. | Simulations are useful to study the heart's ability to generate flow and the interaction between contractility and loading conditions. The left ventricular pressure-volume (PV) relation has been shown to be nonlinear, but it is unknown whether a linear model is accurate enough for simulations. Six models were fitted to... |
2,323,790 | Ultrastructural evidence of ependymal differentiation in a genetically proven atypical teratoid/rhabdoid tumor. | We describe a case of genetically proven atypical teratoid/rhabdoid tumor (ATRT), showing ultrastructural evidence of ependymal differentiation. Such differentiation has not been reported so far in ATRT.</AbstractText>This finding supports the concept that ATRTs as the majority of central nervous system embryonal tumor... |
2,323,791 | Grade II atypical choroid plexus papilloma with normal karyotype. | Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. In the present report, the cytogenetic investigation of an atypical CPP occurring in an infant is detailed.</AbstractText>CPP chromosome preparations were analyzed by giemsa-trypsin-banding (GTG-banding) and comparative genome h... |
2,323,792 | Loss of capture late after right ventricular pacing lead revision: what is the mechanism?<Pagination><StartPage>517</StartPage><EndPage>520</EndPage><MedlinePgn>517-20</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00392-009-0040-2</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y"><L... | Rodent surgery is often an important component in assessing the utility of engineered tissues. A wide variety of surgical procedures can be performed in common laboratory rats or mice and these quite frequently serve as an intermediate step between bench-top experiments and large animal testing or human trials. Given t... |
2,323,793 | Impaired ATP turnover and ADP supply depress cardiac mitochondrial respiration and elevate superoxide in nonfailing spontaneously hypertensive rat hearts. | Although most attention has been focused on mitochondrial ATP production and transfer in failing hearts, less has been focused on the nonfailing hypertensive heart. Here, energetic complications are less obvious, yet they may provide insight into disease ontogeny. We studied hearts from 12-mo-old spontaneously hyperten... |
2,323,794 | Nemaline (actin) myopathy with myofibrillar dysgenesis and abnormal ossification. | We report a 2-year-old boy who presented with marked hypotonia and was dependent on artificial ventilation since birth. He was diagnosed with nemaline (actin) myopathy, based on the cytoplasmic accumulation of thin filament aggregates and marked myofibrillar dysgenesis. Intranuclear rods and dispersed tiny nemaline bod... |
2,323,795 | Bilateral choroid plexus hyperplasia: a case report and management strategies. | Choroid plexus hyperplasia (CPH) is a rare cause of cerebrospinal fluid (CSF) overproduction and shunt-resistant hydrocephalus in infants. If treated with a ventriculoperitoneal (VP) shunt, these patients secondarily develop CSF accumulation along the shunt tract and within the peritoneum. The surgical management of th... |
2,323,796 | A new surgical ventricular restoration technique to reset residual myocardium's fiber orientation: the "KISS" procedure. | The history of surgical reconstruction of the left ventricle after an anterior myocardial infarction shows an evolution of techniques which tend to a more and more physiologic restoration of ventricular shape and volume, with increasing attention to the orientation of myocardial fibers.</AbstractText>We set a new surgi... |
2,323,797 | Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissues. | Leptospirosis is an extremely widespread zoonotic infection with outcomes ranging from subclinical infection to fatal Weil's syndrome. Despite the global impact of the disease, key aspects of its pathogenesis remain unclear. To examine in detail the earliest steps in the host response to leptospires, we used fluorescen... |
2,323,798 | Unilateral oculomotor nerve palsy: unusual sign of hydrocephalus. | We report an unusual case of hydrocephalus in which unilateral oculomotor nerve paralysis was the predominant sign. Misinterpretation of such an atypical clinical sign may lead to inappropriate therapy. We outline the role of intracranial pressure monitoring as an adjunctive diagnostic tool and we suggest a presumptive... |
2,323,799 | The forebrain of actinopterygians revisited. | The forebrain of actinopterygian fishes differs from that of other vertebrates in that it consists of a pair of solid lobes. Lateral ventricles surrounded by nervous tissue are entirely lacking. Comparative anatomical and embryological studies have shown that the unusual configuration of the forebrain in actinopterygia... |
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