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2,323,600 | Vascular endothelial growth factor enhances migration of astroglial cells in subventricular zone neurosphere cultures. | Vascular endothelial growth factor (VEGF) is an endothelial and neuronal survival factor and a mitogen for endothelial cells and astrocytes in both explant and in vivo injury models. In the CNS, interplay between the vasculature and neural stem progenitor (NSP) cells is required for the maintenance of angiogenic/neurog... |
2,323,601 | Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11-13-week scan. | Prenatal diagnosis of open spina bifida is carried out by ultrasound examination in the second trimester of pregnancy. The diagnosis is suspected by the presence of a 'lemon-shaped' head and a 'banana-shaped' cerebellum, thought to be consequences of caudal displacement of the hindbrain. The aim of the study was to det... |
2,323,602 | Cardiomyocyte enlargement, proliferation and maturation during chronic fetal anaemia in sheep. | Chronic anaemia increases the workload of the growing fetal heart, leading to cardiac enlargement. To determine which cellular process increases cardiac mass, we measured cardiomyocyte sizes, binucleation as an index of terminal differentiation, and tissue volume fractions in hearts from control and anaemic fetal sheep... |
2,323,603 | Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine -- a PDE1 inhibitor. | Enhancing cyclic nucleotides signaling by inhibition of phosphodiesterases (PDEs) is known to be beneficial in disorders associated with cognitive decline. The present study was designed to investigate the effect of vinpocetine (PDE1 inhibitor) on intracerebroventricular (i.c.v.) streptozotocin induced experimental spo... |
2,323,604 | Bromodeoxyuridine infused into the cerebral ventricle of adult mice labels nigral neurons under physiological conditions--a method to detect newborn nerve cells in regions with a low rate of neurogenesis. | Methodological differences may explain discrepancies in adult mammalian neurogenesis in the brain outside the widely accepted neurogenic regions, i.e. hippocampus and olfactory bulb/subventricular zone. Here, we describe a method to dissolve and administer bromodeoxyuridine (BrdU) at high concentrations (150mg/mL) into... |
2,323,605 | Evaluation of ventriculomegaly using diffusion tensor imaging: correlations with chronic hydrocephalus and atrophy. | Ventriculomegaly is a common imaging finding in many types of conditions. It is difficult to determine whether it is related to true hydrocephalus or to an atrophic process by using only imaging procedures such as MR imaging after traumatic injury, stroke, or infectious disease. Diffusion tensor (DT) imaging can distin... |
2,323,606 | [Case of brain infarction in the anterior choroidal artery territory with homonymous scotomas]. | We report a case of brain infarction in the anterior choroidal artery territory accompanied homonymous scotomas. A 59-year-old man with diabetes mellitus felt weakness in his left upper and lower extremities. He was admitted to our hospital with mild hemiparesis on his left side. He noticed a small black spot in the le... |
2,323,607 | An automatic integrated approach for stained neuron detection in studying neuron migration. | Neurons that come to populate the six-layered cerebral cortex are born deep within the developing brain in the surface of the embryonic cerebral ventricles. It is very important to detect these neurons for studying histogenesis of the brain and abnormal migration that had been linked to cognitive deficits, mental retar... |
2,323,608 | Death in custody and undiagnosed central neurocytoma. | Fatal brain tumors are often diagnosed well before death. Rarely, they present as sudden and unexpected death. Most of these undiagnosed brain tumors are gliomas. Death in custody is uncommon and can be caused by natural diseases. These are mainly associated with the cardiovascular system and rarely by cancers such as ... |
2,323,609 | An improved lesion detection approach based on similarity measurement between fuzzy intensity segmentation and spatial probability maps. | The application of automatic segmentation methods in lesion detection is desirable. However, such methods are restricted by intensity similarities between lesioned and healthy brain tissue. Using multi-spectral magnetic resonance imaging (MRI) modalities may overcome this problem but it is not always practicable. In th... |
2,323,610 | Function of tau protein in adult newborn neurons. | Levels of tau phosphorylation are high during the developmental period of intense neurite outgrowth, but decrease later. We here investigated whether tau protein plays a role in adult neurogenesis. First we demonstrate that new neurons generated in the subgranular zone express tau in a hyperphosphorylated form. Phospho... |
2,323,611 | Marginal space learning for efficient detection of 2D/3D anatomical structures in medical images. | Recently, marginal space learning (MSL) was proposed as a generic approach for automatic detection of 3D anatomical structures in many medical imaging modalities [1]. To accurately localize a 3D object, we need to estimate nine pose parameters (three for position, three for orientation, and three for anisotropic scalin... |
2,323,612 | Characteristics and surgery of cervical myelomeningocele. | Cervical myelomeningocele (CMMC) is a rare entity in neurosurgical practice, which presents different clinical characteristics compared with other more common lumbosacral variant. Since not much about this lesion has been reported in the literature, this study, herein, demonstrates by cases the clinical characteristics... |
2,323,613 | Right ventricular rupture after lateral thoracotomy for removal of rib-associated telangiectatic osteosarcoma in a dog. | To describe a case of a focal right ventricular rupture following removal of a rib-associated telangiectatic osteosarcoma (TOS) in a dog.</AbstractText>A 2-year-old spayed female mixed-breed dog, weighing 20 kg, was presented in compensated hypovolemic shock due to active bleeding into the thoracic cavity. The dog was ... |
2,323,614 | Blueberry muffin rash as the presenting sign of Aicardi-Goutières syndrome. | A 36-week gestation singleton male infant was born with hypoglycemia, thrombocytopenia, transaminitis, microcephaly, and a generalized eruption of bluish-red nonblanching macules and papules. Head computed tomography showed intracranial calcifications and enlarged ventricles. Skin biopsy was consistent with extramedull... |
2,323,615 | Imaging findings in pyogenic ventriculitis. | Pyogenic ventriculitis is an uncommon but often severe intracranial infection.</AbstractText>Case report with illustrative CT and MRI imaging.</AbstractText>A 49-year-old man presented with an intraparenchymal hematoma with extension of blood into the ventricles. The persistence of intraventricular blood necessitated l... |
2,323,616 | Pharmacokinetic analysis of etoposide distribution after administration directly into the fourth ventricle in a piglet model. | We hypothesize that infusion of chemotherapeutic agents directly into the fourth ventricle potentially may play a role in treating malignant posterior fossa brain tumors. Accordingly, we used a piglet model developed in our laboratory to test the safety of etoposide infusions into the fourth ventricle and to study the ... |
2,323,617 | Ectopic choroid plexus associated with trigeminal neuralgia: case report. | A 55-year-old man underwent a microvascular decompression procedure for a pharmacoresistant trigeminal neuralgia. Preoperative MRI showed a neurovascular conflict between the Vth nerve root and the superior cerebellar artery.</AbstractText>Dissection of the intracisternal trigeminal root was undertaken, and a piece of ... |
2,323,618 | beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. | During embryogenesis, the neural stem cells (NSC) of the developing cerebral cortex are located in the ventricular zone (VZ) lining the cerebral ventricles. They exhibit apical and basal processes that contact the ventricular surface and the pial basement membrane, respectively. This unique architecture is important fo... |
2,323,619 | Anatomic compression caused by high-volume convection-enhanced delivery to the brain. | Our group has pioneered the use of gadoteridol-loaded liposomes (GDLs) in convection-enhanced delivery (CED) using real-time magnetic resonance imaging (MRI) to visualize the distribution of therapeutic agents in nonhuman primate and canine brains. We have shown that this procedure is highly predictable and safe. In th... |
2,323,620 | Occipital transtentorial approach to the precentral cerebellar fissure and posterior incisural space. | To describe the surgical techniques and postoperative clinical outcomes with the occipital transtentorial (OT) approach in patients harboring lesions arising from the precentral cerebellar fissure, posterior incisural space, and adjoining structures.</AbstractText>Twenty-two patients underwent microsurgical resection o... |
2,323,621 | Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis. | Cigarette smoking has been linked to higher susceptibility and increased risk of progressive multiple sclerosis (MS). The effects of smoking on MRI characteristics of patients with MS have not been evaluated.</AbstractText>To compare the MRI characteristics in cigarette smoker and nonsmoker patients with MS.</AbstractT... |
2,323,622 | Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain. | D-Amino acid oxidase (DAO) is a peroxisomal flavoenzyme that catalyzes oxidative deamination of a wide range of D-amino acids. Among the possible substrates of DAO in vivo, D-serine is proposed to be a neuromodulator of the N-methyl-D-aspartate (NMDA) type glutamate receptor. The gene for DAO was reported to be associa... |
2,323,623 | Fornix damage from solitary subependymal giant cell astrocytoma causing postoperative amnesic syndrome. | The amnesic syndrome is characterized by difficulty learning and recalling information, either previously encoded (retro-grade) or newly encountered (anterograde). Various structures within the medial temporal lobe and limbic system of the brain are thought to be important in memory formation and retrieval, as evidence... |
2,323,624 | Interleukin-1beta-induced brain injury in the neonatal rat can be ameliorated by alpha-phenyl-n-tert-butyl-nitrone. | To examine the possible role of inflammatory cytokines in mediating perinatal brain injury, we investigated effects of intracerebral injection of interleukin-1beta (IL-1beta) on brain injury in the neonatal rat and the mechanisms involved. Intracerebral administration of IL-1beta (1 microg/kg) resulted in acute brain i... |
2,323,625 | Cardiac action potential duration and calcium regulation in males and females. | Adult women have longer QT intervals compared with men of a similar age, indicating differences in the speed of repolarisation of the ventricles. We investigate the influences of gender on ventricular electrophysiology and intracellular Ca(2+) regulation of the guinea pig heart. Comparing sexually mature animals, femal... |
2,323,626 | Sex differences in intraventricular hemorrhage rates among very low birth weight newborns. | The influence of male or female sex on newborn outcomes has been recognized for >30 years. Several studies have observed higher mortality and morbidity in males than in females. It is not clear how this sex difference is sustained in postnatal complications such as intraventricular hemorrhage (IVH), especially in ve... |
2,323,627 | Coagulopathy screening and early plasma treatment for the prevention of intraventricular hemorrhage in preterm infants. | Despite the improvement in the assistance and treatment of preterm infants, intraventricular hemorrhage (IVH) remains a frequent complication in these patients. Our aim was to demonstrate the hypothesis that a coagulopathy screening and the early treatment with fresh-frozen plasma (FFP) of proven coagulopathy may contr... |
2,323,628 | Disruption of the neurogenic niche in the subventricular zone of postnatal hydrocephalic hyh mice. | Neural stem cells persist after embryonic development in the subventricular zone (SVZ) niche and produce new neural cells during postnatal life; ependymal cells are a key component associated with this neurogenic niche. In the animal model of human hydrocephalus, the hyh mouse, the ependyma of the lateral ventricles is... |
2,323,629 | Choroid plexus carcinoma: report of two cases. | Choroid plexus carcinomas (CPCs) are rare malignant counterparts of choroid plexus papilloma which occur in infants and children with a predilection for the posterior fossa and have a poor prognosis. We report two cases of CPC diagnosed in a 5-year-old boy and a 12-year-old boy and discuss the clinicopathologic feature... |
2,323,630 | Differential control of collagen synthesis by the sympathetic and renin-angiotensin systems in the rat left ventricle. | In the present study, we tested the hypothesis of the indirect (via the sympathetic nervous system (SNS)) and direct (via AT1 receptors) contributions of Angiotensin II (Ang II) on the synthesis of collagen types I and III in the left ventricle (LV) in vivo. Sympathectomy and blockade of the Ang II receptor AT1 were pe... |
2,323,631 | Measurements of valve circumferences and ventricular wall of fetal hearts in Chile. | Diagnosis of cardiac pathology, valvular stenosis, cardiac dilation, and/or cardiac hypertrophy is underestimated if measures of weight, wall thickness, and valve circumference are not obtained. Routine study methodology protocols allow us to obtain values of these measurements for a correct diagnosis of these cardiopa... |
2,323,632 | Beneficial effects of taurine on cardiac abnormality in NZB/W F1 mice fed with a high-cholesterol diet. | A significantly higher prevalence of cardiovascular disease (CVD) is reported in patients with systemic lupus erythematosus (SLE) as compared with the general population and accounts for approximately 30% of deaths in SLE patients. However, the mechanism of and treatments for CVD in patients with SLE are still unclear.... |
2,323,633 | Cyto-architecture and neuronal types of the dorsomedial cerebral cortex of the common Indian wall lizard, Hemidactylus flaviviridis. | The cyto-architecture and morphology of the neuronal types of the dorsomedial cortex of the lizard, Hemidactylus flaviviridis has been studied with the help of Cresyl violet staining and Golgi impregnation method. The dorsomedial cerebral cortex displayed three neuronal layers. Layer-I contains only few neuronal somas ... |
2,323,634 | Enigmatic central canal contacting cells: immature neurons in "standby mode"? | The region that surrounds the central canal of the spinal cord derives from the neural tube and retains a substantial degree of plasticity. In turtles, this region is a neurogenic niche where newborn neurons coexist with precursors, a fact that may be related with the endogenous repair capabilities of low vertebrates. ... |
2,323,635 | Electrical signalling properties of oligodendrocyte precursor cells. | Oligodendrocyte precursor cells (OPCs) have become the focus of intense research, not only because they generate myelin-forming oligodendrocytes in the normal CNS, but because they may be suitable for transplantation to treat disorders in which myelin does not form or is damaged, and because they have stem-cell-like pr... |
2,323,636 | Clinical and neuroimaging evidence of interictal cerebellar dysfunction in FHM2. | We used multimodal magnetic resonance (MR) techniques [brain diffusion-weighted magnetic resonance imaging, diffusion-weighted imaging (DWI), proton MR spectroscopy (MRS), (1)H-MRS; and skeletal muscle phosphorous MRS, (31)P-MRS] to investigate interictal brain microstructural changes and tissue energy metabolism in fo... |
2,323,637 | ATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility. | Forecasting disease susceptibility requires detection of maladaptive signatures prior to onset of overt symptoms. A case-in-point are cardiac ATP-sensitive K+ (K(ATP)) channelopathies, for which the substrate underlying disease vulnerability remains to be identified. Resolving molecular pathobiology, even for single ge... |
2,323,638 | Myocardial perfusion MRI with sliding-window conjugate-gradient HYPR. | First-pass perfusion MRI is a promising technique for detecting ischemic heart disease. However, the diagnostic value of the method is limited by the low spatial coverage, resolution, signal-to-noise ratio (SNR), and cardiac motion-related image artifacts. In this study we investigated the feasibility of using a method... |
2,323,639 | [Idiopathic normal pressure hydrocephalus]. | Normal pressure hydrocephalus (NPH) is characterized by the classic triad of symptoms including gait disturbance, urinary incontinence, and dementia. Gait impairment represents the cardinal symptom. NPH is associated with a radiological verifiable ventriculomegaly in the absence of elevated cerebrospinal fluid (CSF) pr... |
2,323,640 | Solitary fibrous tumour of the central nervous system: pathological study of eight cases and review of the literature. | Solitary fibrous tumours (SFT) of the central nervous system are rare neoplasms that usually present as dura-based masses and clinically resemble meningiomas. Histologically, they can be similar to haemangiopericytoma or fibrous meningioma. We present herewith a pathological study of eight patients with SFT and compare... |
2,323,641 | Cylindrical channel retractor for intraventricular tumour surgery--a simple and inexpensive device. | Ventricular tumors are excised using both microscope and endoscope as the viewing device. Excision of these tumors requires corticectomy. After these corticectomies, brain has tendency to fall because of CSF drainage. Currently available retractor systems are fixed and thus can be traumatic. On the other hand few syste... |
2,323,642 | [Complications after transcallosal transseptal interforniceal resection of hypothalamic hamartoma: analysis of 37 cases]. | To summarize the post-operative complications of resection of hypothalamic hamartoma (HH) through transcallosal transseptal interforniceal approach.</AbstractText>Thirty-seven HH patients, 26 males and 11 females, aged 8.7 underwent resection of the tumor via the transcallosal transseptal interforniceal approach. The s... |
2,323,643 | Robotic placement of a CNS ventricular reservoir for administration of chemotherapy. | The application of robotic technology to surgery holds great promise for improving surgical outcomes and reducing morbidity. We hypothesized that image-guided, robotic placement of a CNS ventriculostomy reservoir for intraventricular chemotherapy is safe, highly accurate, and highly reproducible. Eleven patients requir... |
2,323,644 | Is the routine placement of a CSF reservoir following endoscopic third ventriculostomy justified? | Endoscopic third ventriculostomy (ETV) is a well established treatment for selected cases of obstructive hydrocephalus. However, it does carry a significant rate of failure, which can be abrupt and life threatening. The present study analyses the benefits versus the risks of routine CSF reservoir insertion during ETV. ... |
2,323,645 | Depletion of B lymphocytes from cerebral perivascular spaces by rituximab. | Rituximab is a recombinant chimeric monoclonal antibody against CD20, a molecule expressed on cells of the B-cell lineage. A phase 2 clinical trial recently provided strong evidence of the beneficial effects of rituximab in patients with relapsing-remitting multiple sclerosis. We and other investigators previously demo... |
2,323,646 | Hypothalamic involvement predicts cardiovascular risk in adults with childhood onset craniopharyngioma on long-term GH therapy. | Craniopharyngioma patients without GH therapy are at an increased cardiovascular disease (CVD) risk and particularly concerning women. No previous study on long-term GH therapy in adults with childhood onset (CO) craniopharyngioma was identified.</AbstractText>To investigate CVD risk in adults with CO craniopharyngioma... |
2,323,647 | Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patterns. | Multiple sclerosis (MS) is often accompanied by cognitive dysfunction. A negative correlation between cerebral lesion load and atrophy and cognitive performance has been pointed out almost consistently. Further, the distribution of lesions might be critical for the emergence of specific patterns of cognitive deficits.<... |
2,323,648 | T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes. | Low-voltage-activated calcium channels are reexpressed in ventricular myocytes in pathological conditions associated with hypoxic episodes, but a direct relation between oxidative stress and T-type channel function and regulation in cardiomyocytes has not been established. We aimed to investigate low-voltage-activated ... |
2,323,649 | Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface. | The vascular network of the brain is formed by the invasion of vascular sprouts from the pia mater toward the ventricles. Following angiogenesis of the primary vascular network, brain vessels experience a maturation process known as barriergenesis, in which the blood-brain barrier is formed. In this minireview, we disc... |
2,323,650 | Oxyntomodulin reduces expression of glucagon-like peptide 1 receptor in the brainstem of chickens. | Oxyntomodulin (OXM) is a peptide released from the gut and attenuates food intake by acting on hypothalamus. However, its role at the molecular level is not well studied. In the first section of this study, we analysed the effect of OXM on food intake behaviour after injecting into the lateral ventricle of chickens. Th... |
2,323,651 | Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential. | Evaluation of the potential for delayed ventricular repolarization and proarrhythmia by new drugs is essential. We investigated if dog left ventricular midmyocardial myocytes (LVMMs) that can be used as a preclinical model to assess drug effects on action potential duration (APD) and whether in these cells, short-term ... |
2,323,652 | Surgical management of lateral-ventricle metastases: report of 29 cases in a single-institution experience. | The aim of this study was to review the outcome of patients undergoing surgery for treatment of lateral-ventricle metastases.</AbstractText>Imaging information and chart reviews of operative reports were used to conduct a retrospective analysis in 29 patients who underwent resection of lateral-ventricle metastases at t... |
2,323,653 | High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. | The development of quantitative techniques in mass spectrometry has generated the ability to systematically monitor protein expression. Isobaric tags for relative and absolute quantification (iTRAQ) have become a widely used tool for the quantification of proteins. However, application of iTRAQ methodology using ion tr... |
2,323,654 | A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain. | At present it is widely accepted that there are at least two neurogenic sites in the adult mammalian brain: the subventricular zone (SVZ) of lateral ventricles and the subgranular zone (SGZ) of the hippocampus dentate gyrus. The adult proliferation rate declines with aging and is altered in several neurodegenerative pa... |
2,323,655 | Brain phospholipid arachidonic acid half-lives are not altered following 15 weeks of N-3 polyunsaturated fatty acid adequate or deprived diet. | Previous studies have infused radiolabeled arachidonic acid (AA) into rat brains and followed AA esterification into phospholipids for up to 24 h; however, the half-life of AA in rat brain phospholipids is unknown. Eighteen day old rats were fed either an n-3 PUFA adequate or deprived diet for 15 weeks. Following the 1... |
2,323,656 | The rostral migratory stream and olfactory system: smell, disease and slippery cells. | In the mammalian brain, olfaction is an important sense that is used to detect odors of different kinds that can warn of off food, to produce a mothering instinct in a flock or group of animals, and to warn of danger such as fire or poison. The olfactory system is made up of a long-distance rostral migratory stream tha... |
2,323,657 | Angiopoietin 1 counteracts vascular endothelial growth factor-induced blood-brain barrier permeability and alleviates ischemic injury in the early stages of transient focal cerebral ischemia in rats. | To examine the effects of intraventricular pre-treatment with a combination of recombinant adeno-associated virus vectors encoding VEGF (rAAV-VEGF) and Ang1 (rAAV-Ang1) on early stroke in a rat model of transient middle cerebral artery occlusion (tMCAO).</AbstractText>rAAV-VEGF/rAAV-Ang1 or rAAV-VEGF/rAAV-null vector w... |
2,323,658 | Secreted products from the porcine choroid plexus accelerate the healing of cutaneous wounds. | The choroid plexus (CP), located at the blood-brain interface, is partially responsible for maintaining the composition of cerebrospinal fluid. Epithelial cell clusters isolated from the CP secrete numerous biologically active molecules, and are neuroprotective when transplanted in animal models of Huntington's disease... |
2,323,659 | Modulation of the sodium-calcium exchanger in the rat kidney by different sequential stressors. | Stress, if exaggerated, modulates a variety of metabolic pathways and results in development of serious health consequences. The cell membrane sodium-calcium exchanger (NCX) is a major calcium extrusion system and is also modulated by stress. It has been shown previously that mRNA, protein levels and activity of the ty... |
2,323,660 | Conventional MRI at presentation does not predict clinical response to radiation therapy in children with diffuse pontine glioma. | Diffuse pontine glioma is a pediatric brain tumor with a median survival time of 1 year and few long-term survivors. Conventional MRI has not been shown to predict overall survival. With this dismal prognosis, clinical improvement after radiation therapy might be a more relevant issue.</AbstractText>To determine whethe... |
2,323,661 | The potential of dual camera systems for multimodal imaging of cardiac electrophysiology and metabolism. | Fluorescence imaging has become a common modality in cardiac electrodynamics. A single fluorescent parameter is typically measured. Given the growing emphasis on simultaneous imaging of more than one cardiac variable, we present an analysis of the potential of dual camera imaging, using as an example our straightforwar... |
2,323,662 | MR spectroscopy and diffusion tensor imaging of the brain in Sjögren-Larsson syndrome. | Diffusion tensor imaging (DTI) is reported for the first time in a patient with Sjögren-Larsson syndrome, an autosomal recessive neurocutaneous disorder. Magnetic resonance spectroscopy (MRS) revealed normal levels of choline, creatine and N-acetyl aspartate (NAA) and the characteristic lipid signals in the white ... |
2,323,663 | [Safety and efficacy of the use of glycoprotein IIb/IIIa inhibitors in the invasive treatment of patients with ST-elevation acute coronary syndrome].<Pagination><StartPage>4</StartPage><EndPage>9</EndPage><MedlinePgn>4-9</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">The purpose of the study was to... | The heart at the time of Sir William Harvey originally was thought to be an insensate organ. Today, however, we know that this organ is innervated by sensory nerves that course centrally though mixed nerve pathways that also contain parasympathetic or sympathetic motor nerves. Angina or cardiac pain is now well recogni... |
2,323,664 | Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. | Current therapies for glioblastoma (GBM) target bulk tumor through measures such as resection and radiotherapy. However, recent evidence suggests that targeting a subset of tumor cells, so-called cancer stem cells, may be critical for inhibiting tumor growth and relapse. The subventricular zone (SVZ), which lines the v... |
2,323,665 | Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. | Melatonin was shown to reduce blood pressure, enhance nitric oxide availability and scavenge free radicals. There is, however, a shortage of data with respect to the effect of melatonin on pathological left ventricular remodelling associated with haemodynamic overload.</AbstractText>We investigated whether melatonin wa... |
2,323,666 | Adenovirus-mediated stromal cell-derived factor-1 alpha gene transfer improves cardiac structure and function after experimental myocardial infarction through angiogenic and antifibrotic actions. | Stromal cell-derived factor 1 alpha (SDF-1) is not only a major chemotactic factor, but also an inducer of angiogenesis. The effects of SDF-1 alpha on the left ventricular remodeling in a rat myocardial infarction (MI) model were analyzed. Myocardial infarction was induced by ligation of the left coronary artery in rat... |
2,323,667 | Use of tissue glue to prevent collapse of the cortical mantle during and after cranial surgery in children: a technical note. | Young children with significant ventricular dilatation or large intracranial fluid spaces often have a very thin cortical mantle as a result of persistently raised intracranial pressure. This rim of cortex has a tendency to fall away from the dura into the cavity during and after intracranial surgery, due to the lack o... |
2,323,668 | Inadvertent lead placement in the left ventricle: a case report and brief review. | Inadvertent lead placement in the left ventricle (LV) is an uncommon and often under-diagnosed complication of cardiac device implantation. Thromboembolic (TE) events are common and usually secondary to fibrosis or thrombus formation on or around the lead. Anticoagulation can prevent TE events. Percutaneous and surgica... |
2,323,669 | Death receptor 5 agonist TRA8 in combination with the bisphosphonate zoledronic acid attenuated the growth of breast cancer metastasis. | Bone metastasis affects the majority of patients with advanced breast cancer and no adequate therapy exists. Bisphosphonates, like zoledronic acid, inhibit the osteolytic component of tumor growth in osseous tissues, but these drugs are not curative. The current study evaluated the combination of zoledronic acid with d... |
2,323,670 | Isolated homonymous hemianopsia due to lateral posterior choroidal artery region infarction: a case report. | An 86-year-old, right-handed, hypertensive man suddenly experienced blurring of vision predominating in the left visual field. Neurological examinations were normal, except for left homonymous hemianopsia. Goldmann visual field testing revealed a left congruent incomplete homonymous hemianopsia with macular splitting. ... |
2,323,671 | Simulation of endoscopic third ventriculostomy in fresh cadaveric specimens. | The purpose of this research is to describe and analyze the endoscopic anatomy of cerebral ventricles, especially of the lateral ventricle and third ventricle.</AbstractText>47 brains of adult human cadavers were studied at the Death Check Unit (DCU) of São Paulo. Age, sex, day and approximate time of death, day a... |
2,323,672 | [Microsurgical treatment and prevention of postoperative complications for the fourth ventricle tumors in adults]. | To explore the microneurosurgical technique and prevention of postoperative complications for the fourth ventricle tumors in adults.</AbstractText>We retrospectively analyzed the clinical data of 68 patients with the fourth ventricle tumors between August 2005 and August 2007 in Xiangya Hospital after microsurgical ope... |
2,323,673 | Renal studies provide an insight into cardiac extracellular matrix remodeling during health and disease. | The remodeling of a heart ventricle after myocardial infarction involves numerous inflammatory mediators that may trigger a long-lasting and a highly fibrogenic process. Likewise, in the kidney, acute and chronic injuries may lead to abnormal extracellular matrix deposition and eventually lead to the loss of renal func... |
2,323,674 | A brain slice culture model for studies of endogenous and exogenous precursor cell migration in the rostral migratory stream. | The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone (SVZ) cells reach the olfactory bulb (OB) in rodents. This migration has been well studied in vivo, but an organotypic in vitro model would facilitate more experimental investigations. Here we introduce a slice culture prepar... |
2,323,675 | [Intraventricular cavernoma in the foramen of Monro: particularities due to its atypical location]. | Although cavernomas are relatively common vascular malformations in the central nervous system, they are rarely located in the ventricles and are even more rarely located in the region of the foramen of Monro. This atypical location results in a series of differential clinical and radiological characteristics that can ... |
2,323,676 | Counseling in isolated mild fetal ventriculomegaly. | In this Review we aim to provide up-to-date and evidence-based answers to the common questions regarding the diagnosis of isolated mild fetal ventriculomegaly (VM). A literature search was performed to identify all reports of antenatal VM in the English language literature. In addition, reference lists of articles iden... |
2,323,677 | Down's syndrome and the pattern of congenital heart disease in a community with high parental consanguinity.<Pagination><StartPage>CR409</StartPage><EndPage>CR412</EndPage><MedlinePgn>CR409-12</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">It is speculated that parents' con... | The target of research is to compare the changes of systolic and diastolic functions of the left ventricle in patients with at least one month infarction after infarct-dependent artery recanalization through elective stenting. The group of 60 patients was selected, 47 men and 13 women, who underwent hospitalization in ... |
2,323,678 | Is all "communicating" hydrocephalus really communicating? Prospective study on the value of 3D-constructive interference in steady state sequence at 3T. | 3D-constructive interference in steady state (3D-CISS) sequence has been used to assess the CSF pathways. The aim of this study was to investigate the additive value of 3D-CISS compared with conventional sequences in the diagnosis of obstructive membranes in hydrocephalus.</AbstractText>A total of 134 patients with hyd... |
2,323,679 | Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia. | White matter (WM) hyperintensities on T2-weighted MR imaging are the most common imaging manifestation of neurotoxic effects of therapy for central nervous system (CNS) prophylaxis in childhood acute lymphoblastic leukemia (ALL). This study uses voxel-based analyses (VBA) of T2-weighted imaging of patients during treat... |
2,323,680 | Supratentorial abnormalities in the Chiari II malformation, III: The interhemispheric cyst. | Our clinical observations noted an interhemispheric "cyst," a protrusion of the posterior superior third ventricle, in fetuses with myelomeningocele (MMC). The study analyzed the frequency of this observation and features that influence its visualization.</AbstractText>We searched for cases of fetal MMC sonographically... |
2,323,681 | Papillary glioneuronal tumor--prognostic value of the extension of surgical resection. | Papillary glioneuronal tumors (PGNT) is well-recognized in the literature, although reports usually have not attempted a critical analysis of their characteristics. We report two PGNT and perform a comprehensive review of the published cases, aiming to clarify their clinical, imaging and histopathological features.</Ab... |
2,323,682 | L1CAM mutation in association with X-linked hydrocephalus and Hirschsprung's disease. | X-linked hydrocephalus (XLH) is characterized by increased intracranial ventricle size and head circumference secondary to aqueduct of Sylvius congenital stenosis. Exceedingly rare is the concurrence of XLH and Hirschsprung's disease (HSCR) with a theoretical incidence of 1 in 125-250 million cases. Herein, we are desc... |
2,323,683 | Phylogeny of the telencephalic subventricular zone in sauropsids: evidence for the sequential evolution of pallial and subpallial subventricular zones. | The telencephalon of birds and placental mammals harbors a proliferative subventricular zone (SVZ) in the subpallium as well as the pallium. Turtles, which are phylogenetically intermediate between bird, and mammals, exhibit at best a rudimentary SVZ. This suggests that SVZs evolved independently in mammals and birds, ... |
2,323,684 | Sellar neuroblastoma mimicking a pituitary tumour: case report and review of the literature. | Neuroblastomas of the sellar region are exceedingly rare. Only 2 cases have previously been reported. Management of these tumours depends on the tumour's primary site, the patient's age and histopathological features. We are reporting the case of a 43-year-old woman who developed progressive bitemporal hemianopsia and ... |
2,323,685 | Influence of L-arginine on the nitric oxide concentration and level of oxidative stress during ischemia-reperfusion injury in a rat model. | This study aimed at evaluating whether supplementation of L-arginine in the course of ischemia and reperfusion syndrome after acute, experimental ischemia of the hind legs of the rat, could influence nitric oxide (NO) concentration and selected biochemical parameters concentration related to the oxidative stress.</Abst... |
2,323,686 | Role of convective flow in carmustine delivery to a brain tumor. | This paper presents a three-dimensional patient-specific simulation of carmustine delivery to brain tumor. The simulation investigates several crucial factors, particularly the role of convective flow, affecting drug delivery efficacy.</AbstractText>The simulation utilizes a complete three-dimensional tissue geometry c... |
2,323,687 | Longitudinal two-dimensional strain rate imaging: a potential approach to predict the response to cardiac resynchronization therapy.<Pagination><StartPage>677</StartPage><EndPage>687</EndPage><MedlinePgn>677-87</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10554-009-9480-z</ELocationID><Abstr... | The purpose of our study was to test the usefulness of speckle-tracking two-dimensional echocardiography (in particular longitudinal strain and strain rate) in predicting the response to cardiac resynchronization therapy. The standard approach has been tissue Doppler-based echocardiographic imaging (TDI) has initially ... |
2,323,688 | Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular pathology after experimental traumatic brain injury. | "Naked" human mesenchymal stem cells (MSC) are neuro-protective in experimental brain injury (TBI). In a controlled cortical impact (CCI) rat model, we investigated whether encapsulated MSC (eMSC) act similarly, and whether efficacy is augmented using cells transfected to produce the neuro-protective substance glucagon... |
2,323,689 | Prevalence, incidence, and risk factors of lacunar infarcts in a community sample. | Lacunar infarcts are small cavitated lesions no larger than 2 cm in diameter. Although often asymptomatic, they have been suggested as an important pathologic substrate of vascular dementia. The prevalence and risk factor profile of lacunar infarction has been variously reported, but the incidence data are scarce for l... |
2,323,690 | First report of the simultaneous occurrence of choroid plexus papilloma and meningioma in a dog. | A 7-year-old spayed female English Cocker Spaniel was examined because of a 1-week history of lethargy, stumbling over objects and circling, and the presence of two tonic-clonic generalised seizures two days before presentation. The neurological signs suggested a lesion involving the right forebrain. Computed tomograph... |
2,323,691 | Neocortical neurogenesis: morphogenetic gradients and beyond. | Each of the five cellular layers of the cerebral neocortex is composed of a specific number of a single predominant 'class' of projection neuron. The projection neuron class is defined by its unique morphology and axonal projections to other areas of the brain. Precursor cell populations lining the embryonic lateral ve... |
2,323,692 | Scleroderma linearis: hemiatrophia faciei progressiva (Parry-Romberg syndrom) without any changes in CNS and linear scleroderma "en coup de sabre" with CNS tumor. | Hemifacial atrophy (Parry-Romberg syndrome) is a relatively rare disease. The etiology of the disease is not clear. Some authors postulate its relation with limited scleroderma linearis. Linear scleroderma "en coup de sabre" is characterized by clinical presence of most commonly one-sided linear syndrome. In a number o... |
2,323,693 | Histological studies on the telencephalon of Hynobius leechii at the metamorphosis phase and the adult phase. | To investigate the telencephalon developmental characteristics of Hynobius leehii, and enrich the research data of comparable neurobiology and nervous system development of amphibian.</AbstractText>HE staining and Nissl staining methods were used to study the telencephalon histological structure of Hynobius leechii at ... |
2,323,694 | Primary intraventricular schwannomas. | Schwann cell tumors arising within the neuraxis and in an intraventricular location are an exceedingly rare tumor entity of the brain. The authors present the first case of a cellular intraventricular schwannoma occurring in the fourth ventricle. The pertinent literature is reviewed. A 71-year-old female was admitted t... |
2,323,695 | Quantitative tissue echogenicity of the neonatal brain assessed by ultrasound imaging. | The aim of this study was to propose a method for measuring the echogenicity of several neonatal brain structures for quantitative interpretation of ultrasound images. To do this, 40 preterm neonates (24-34 weeks' gestation) with adequate birth weight for gestational age were studied. On the third day after delivery, a... |
2,323,696 | Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: relationship with serum concentrations of GH and responses to appetite-regulating peptides. | Objectives were to (1) characterize the relationship of third-ventricle (IIIV) cerebrospinal fluid (CSF) concentrations of growth hormone-releasing hormone (GHRH) with concentrations of GH in the peripheral circulation; and (2) assess the influence of acute administration of appetite-regulating peptides leptin (anti-or... |
2,323,697 | Changes in the frequency spectrum, the P-P interval, and the bispectral index during ventricular fibrillation are physiologic indicators of ventricular fibrillation duration.<Pagination><StartPage>527</StartPage><EndPage>533</EndPage><MedlinePgn>527-33</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.... | The 3-phase time-sensitive model by Weisfeldt and Becker in 2002 has resulted in a redirection of efforts toward developing treatment algorithms specific to each phase of cardiac arrest. In this study, a number of physiologic indicators of ventricular fibrillation (VF) duration were investigated. The bispectral index w... |
2,323,698 | Late spinal cord metastasis of fourth ventricle ependymoma appeared nineteen years after the initial treatment. | Spinal cord dissemination (metastasis) of a fourth ventricle ependymoma more than ten years after surgical resection is extremely rare. In this report, we present an unusual case of a fourth ventricle ependymoma with metastasis to the thoracic spinal cord 19 years after the initial therapy, but without local recurrence... |
2,323,699 | Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model. | Maternal infection during pregnancy increases risk of severe neuropsychiatric disorders, including schizophrenia and autism, in the offspring. The most consistent brain structural abnormality in patients with schizophrenia is enlarged lateral ventricles. However, it is unknown whether the aetiology of ventriculomegaly ... |
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