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2,323,800 | Effects of chronic intracerebral prolactin on the oxytocinergic and vasopressinergic system of virgin ovariectomized rats. | Chronic intracerebroventricular (icv) infusion of prolactin (PRL) into the cerebral ventricles and mimicking central hyperprolactinemia in lactation has recently been shown to reduce anxiety and neuronal as well as neuroendocrine responses to acute stressor exposure. Here, we studied the effects of icv PRL on the activ... |
2,323,801 | Feasibility of automated 3-dimensional fetal cardiac screening in routine ultrasound practice. | The purpose of this study was to prospectively assess the clinical feasibility of an automated 3-dimensional (3D) software tool for extended basic cardiac screening in routine ultrasound practice.</AbstractText>During the 2-month study period, all gravidas fitting our inclusion criteria were consecutively included. Car... |
2,323,802 | Heparin-coated extracorporeal circulation systems in heart surgery. | Despite the progress accomplished in the field of off-pump heart surgery, the vast majority of cardiac operations are still performed with the use of extracorporeal circulation, otherwise known as "heart-lung machine." This valuable tool, however, is connected with various complications, partly deriving from the applic... |
2,323,803 | Epidermal growth factor induces the progeny of subventricular zone type B cells to migrate and differentiate into oligodendrocytes. | New neurons and oligodendrocytes are continuously produced in the subventricular zone (SVZ) of adult mammalian brains. Under normal conditions, the SVZ primary precursors (type B1 cells) generate type C cells, most of which differentiate into neurons, with a small subpopulation giving rise to oligodendrocytes. Epiderma... |
2,323,804 | Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice. | The exercise-induced enhancement of learning and memory, and its ability to slow age-related cognitive decline in humans led us to investigate whether running stimulates periventricular (PVR) neural stem cells (NSCs) in aging mice, thereby augmenting the regenerative capacity of the brain. To establish a benchmark of n... |
2,323,805 | Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development. | Brain microglia are related to peripheral macrophages but undergo a highly specific process of regional maturation and differentiation inside the brain. Here, we examined this deactivation and morphological differentiation in cerebral cortex and periventricular subcortical white matter, the main "fountain of microglia"... |
2,323,806 | Brain ventricular wall movement assessed by a gated cine MR trueFISP sequence in patients treated with endoscopic third ventriculostomy. | The purpose of this study was to investigate the value of brain ventricular wall movement assessment with a gated cine trueFISP MR sequence for the diagnosis of endoscopic third ventriculostomy (ETV) patency. Sixteen healthy volunteers and ten consecutive patients with noncommunicating hydrocephalus were explored with ... |
2,323,807 | Exploration of shape variation using localized components analysis. | Localized Components Analysis (LoCA) is a new method for describing surface shape variation in an ensemble of objects using a linear subspace of spatially localized shape components. In contrast to earlier methods, LoCA optimizes explicitly for localized components and allows a flexible trade-off between localized and ... |
2,323,808 | CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem. | Recently, a new neuropeptide, named nesfatin-1, was discovered. It has been reported that nesfatin-1 inhibits food intake after injection into the third ventricle as well as intraperitoneal (ip) injection. Cholecystokinin (CCK) is well established to play a role in the regulation of food intake. The aim of the study wa... |
2,323,809 | Post-mortem investigation of calcium content in liver, heart, and skeletal muscle in accidental hypothermia cases. | The identification of hypothermia as cause of the death was always quite problematic in the field of forensic medicine. The aim of the present study was to verify the determination of calcium content in post-mortem liver, heart, and skeletal muscle samples as the biochemical marker defining hypothermia as the cause of ... |
2,323,810 | Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism. | Epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic acids (EETs), to their supposedly less active form, dihydroxyeicosatrienoic acids (DHETs). EETs control cerebral blood flow, exert analgesic, anti-inflammatory and angiogen... |
2,323,811 | VEGF enhance cortical newborn neurons and their neurite development in adult rat brain after cerebral ischemia. | To study the effect of VEGF overexpression on development of cortical newborn neurons in the brains after stroke, we injected human VEGF(165)-expressive plasmids (phVEGF) into the lateral ventricle of rat brains with a transient middle cerebral artery occlusion (MCAO). An injection of phVEGF significantly promoted angi... |
2,323,812 | Serotonin receptor subtypes influence prolactin secretion in the turkey. | Serotonin (5-HT) stimulation of prolactin (PRL) secretion is mediated through the dopaminergic (DAergic) system, with 5-HT ligands having no direct effect on pituitary PRL release. Infusion of 5-HT into the third ventricle (ICV) or electrical stimulation (ES) of the medial preoptic area (POM) or the ventromedial nucleu... |
2,323,813 | Yolk sac tumor in the fourth ventricle: a case report. | The nongerminomatous germ cell tumor occurring in the fourth ventricle is extremely rare. A 9-year-old boy presented with symptoms of obvious headache, projectile vomiting, diplopia and motor weakness. MRI scanning revealed lesions occupying the fourth ventricle, with dual-lateral ventricle expansion after gadolinium a... |
2,323,814 | Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease. | Recently, interest in the rat as an animal model of Alzheimer's disease (AD) has been growing. We have previously described the Tg6590 transgenic rat line expressing the amyloid precursor protein containing the Swedish AD mutation (K670M/N671L) that shows early stages of Abeta deposition, predominantly in cerebrovascul... |
2,323,815 | A case of idiopathic hypereosinophilic syndrome with leptomeningeal dissemination and intraventricular mass lesion: an autopsy report. | A 43-year-old female presented with idiopathic hypereosinophilic syndrome (HES) manifesting as an intraventricular mass lesion and leptomeningeal and cerebral parenchymal infiltration by eosinophils, lymphocytes and macrophages. She had no history of either malignancy or allergic disorder. She complained of hearing dis... |
2,323,816 | [A case of a congenital high-grade hydrocephalus internus and Dandy-Walker syndrome in a black and white German Holstein calf]. | A black and white female German Holstein calf showed a highly deformed cranium. The animal was not able to stand. Further findings were bilateral strabismus divergens and negative pupillary light reflexes. Magnetic resonance imaging and pathological-anatomical examination showed that the cerebrum was replaced to a high... |
2,323,817 | [Microsurgical anatomy and clinical application of infratentorial supracerebellar keyhole approach]. | To explore the feasibility of applying the infratentorial supracerebellar keyhole approach for removing tumors of pineal region.</AbstractText>Infratentorial supracerebellar keyhole approach was performed in 16 cadaveric heads with intracranial vessels perfused by colored latex. The microscopic structure was observed. ... |
2,323,818 | Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesis. | Ependymomas derive from ependymal cells that cover the cerebral ventricles and the central canal of the spinal cord. The molecular alterations leading to ependymomal oncogenesis are not completely understood.</AbstractText>The authors performed array-based expression profiling on a series of 34 frozen ependymal tumors ... |
2,323,819 | Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo. | The Notch1 signaling pathway is regarded as one of the main regulators of neural stem cell behavior during development, but its role in the adult brain is less well understood. We found that Notch1 was mainly expressed in doublecortin (DCX)-positive cells corresponding to newborn neurons, whereas the Notch1 ligand, Jag... |
2,323,820 | [The genetics of dementias. Part 2: The biology of Alzheimer's disease]. | The brains of AD patients are characterized by cortical atrophy in the form of gyral shrinkage,widening of the sulci, and enlargement of the ventricles. The fi rst regions to be affected are the hippocampus and entorhinal cortex. At later stages of the disease appear: 1) accumulation of extracellular senile plaques (di... |
2,323,821 | Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. | We have identified a novel population of cells in the subventricular zone (SVZ) of the mammalian brain that expresses beta4 tubulin (betaT4) and has properties of primitive neuroectodermal cells. betaT4 cells are scattered throughout the SVZ of the lateral ventricles in adult human brain and are significantly increased... |
2,323,822 | Midkine gene transfer protects against focal brain ischemia and augments neurogenesis. | Midkine is a heparin-binding growth factor having various biological activities including chemotaxis of inflammatory cells, angiogenesis and migration of neuronal cells. These biological activities are expected to have a great impact on the pathology of brain infarction in subacute phase. Therefore, we investigated the... |
2,323,823 | Effects of body size and body fatness on left ventricular mass in children and adolescents: Project HeartBeat! | Left ventricular mass (LVM) is a strong predictor of cardiovascular disease in adults. Available study findings on effects of body fatness on LVM in children are inconsistent. Understanding the impact of body fat on LVM in children may help prevent excessive LVM through measures to reduce overweight and obesity.</Abstr... |
2,323,824 | PDGF stimulates the massive expansion of glial progenitors in the neonatal forebrain. | Platelet-derived growth factor (PDGF) plays a major role in regulating migration, proliferation, and differentiation of glial progenitors during normal brain development and in the abnormal proliferation and dispersion that drives the formation of malignant gliomas. To further explore the relationship between PDGF's ef... |
2,323,825 | Parental level of anxiety, sense of coherence and state of mind when choroid plexus cysts have been identified at a routine ultrasound examination in the second trimester of pregnancy: a case control study. | The aim of the study was to compare parents' experience of a routine ultrasound examination in the second trimester, when a choroid plexus cyst/cysts (CPC) were found (Study group; n = 22), with matched controls where no fetal deviations were identified (Control group, n = 66). All the parents had participated in a lar... |
2,323,826 | Rapid evolution of a choroid plexus papilloma in an infant. | Choroid plexus papilloma (CPP) is primarily found in children less than 2 years of age but can also be diagnosed prenatally. The presentation of a large CPP during infancy is not uncommon and surgical excision is usually recommended without delays. As a result, information about the growth rate of CPP during infancy is... |
2,323,827 | Bilateral deafness and blindness from a IVth ventricular medulloblastoma. | Delay in diagnosis and management of intra-cranial tumors can be costly if not actually fatal. We present a 16-year-old Nigerian girl with bilateral deafness and blindness from a cerebellar intra-axial medulloblastoma. She has regained some hearing function in both ears 5 months after tumor resection. She remains blind... |
2,323,828 | Meningiomas of the lateral ventricle - a report of 15 cases. | Lateral ventricular meningiomas are rare tumours that pose considerable surgical challenge. This study attempts to analyse some of the important clinical features of these tumours and review technical considerations in surgery for lateral ventricular meningiomas. A retrospective analysis of the case records of patients... |
2,323,829 | Unusual subacute diencephalic edema associated with a trapped fourth ventricle: resolution following foramen magnum decompression. | A 4-year-old girl with a ventriculoperitoneal shunt presented to us with complaints of ataxia and altered consciousness. These symptoms were subacute at onset and progressive in nature.</AbstractText>Radiological evaluation revealed a trapped fourth ventricle with brainstem compression, associated with abnormal diffuse... |
2,323,830 | The ependymal route for insulin-like growth factor-1 gene therapy in the brain. | I.c.v. administration of the peptide insulin-like growth factor-1 (IGF-1) has been shown to be an effective neuroprotective strategy in the brain of different animal models, a major advantage being the achievement of high concentrations of IGF-1 in the brain without altering serum levels of the peptide. In order to exp... |
2,323,831 | Cell proliferation and death in the brain of active and hibernating frogs. | 'Binomial' cell proliferation and cell death have been studied in only a few non-mammalian vertebrates, such as fish. We thought it of interest to map cell proliferation/apoptosis in the brain of the frog (Rana esculenta L.) as this animal species undergoes, during the annual cycle, physiological events that could be a... |
2,323,832 | Localization of zip1 and zip4 mRNA in the adult rat brain. | The localization of two members of the Slc39a (zip1 and zip4) family of zinc transporters was examined in the brains of adult mice. Zip1 was highly enriched in brain regions with high densities of neuronal cell bodies, including the hippocampus, thalamus, and perifontal cortex. Zip1 was also expressed in commissural fi... |
2,323,833 | Early combined treatment with cilostazol and bone marrow-derived endothelial progenitor cells markedly attenuates pulmonary arterial hypertension in rats. | We investigated whether early combined cilostazol and bone marrow-derived endothelial progenitor cell (BMDEPC) treatment offers synergistic benefit in ameliorating monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. Male Sprague-Dawley rats (n = 10/group) were randomized to receive saline injecti... |
2,323,834 | The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. | Upon central nervous system injury, the extracellular concentrations of nucleotides and cysteinyl-leukotrienes, two unrelated families of endogenous signalling molecules, are markedly increased at the site of damage, suggesting that they may act as 'danger signals' to alert responses to tissue damage and start repair. ... |
2,323,835 | The neurocognitive outcome of mild isolated fetal ventriculomegaly verified by prenatal magnetic resonance imaging. | Neurocognitive outcome of preschool children, prenatal diagnosis of isolated mild ventriculomegaly compared with 2 control groups.</AbstractText>Case-controlled study at the University Hospital of Tel Aviv between October 1999 and December 2002. Study groups consisted of 12 children with bilateral isolated mild ventric... |
2,323,836 | Characterization of promoter elements required for cardiac chamber-specific expression. | Salmon cardiac natriuretic peptide (sCP, an A-type natriuretic peptide) is an excellent model for the study of cardiac chamber-specific gene expression because it is uniquely specific to the heart and its promoter drives gene expression effectively in mammalian cardiac atrial but not in ventricular cells. We have now p... |
2,323,837 | Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model. | In an attempt to elucidate the involvement of cyclooxygenase (COX) enzymes, particularly COX-1, in epileptogenesis, the localization of COX-1 and COX-2 expression in the mouse kindling model was analyzed by immunohistochemistry. COX-2 was predominantly observed in brain neurons and its concentration in the hippocampus ... |
2,323,838 | Successful diagnostic and therapeutic intrauterine fetal interventions by natural orifice transluminal endoscopic surgery (with videos). | Despite advances in the development of fetal surgery, morbidity and mortality are substantial. A natural orifice transluminal endoscopic surgery (NOTES)-guided approach to the gravid uterus may offer a less-invasive technique.</AbstractText>To assess the feasibility of NOTES for diagnostic and therapeutic intrauterine ... |
2,323,839 | Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice. | NOR1, Nur77 and Nurr1 are orphan nuclear receptors and members of the NR4A subfamily. Here, we report that the expression of hypothalamic NOR1 was remarkably decreased in mildly obese beta-endorphin-deficient mice and obese db/db mice with the leptin receptor mutation, compared with age-matched wild-type mice, whereas ... |
2,323,840 | [Brachial versus central blood pressure and vascular stiffness]. | Central blood pressure (BP) estimates the true load imposed on the left ventricle to a higher degree than does brachial BP. Increased aortic pulse wave velocity (aPWV) and central BP are risk markers for cardiovascular disease. Both can be measured by simple and noninvasive methods. Guidelines recommend measurements of... |
2,323,841 | A pediatric experience with endoscopic third ventriculostomy for hydrocephalus. | Pediatric neuroscience nurses deal with many children with hydrocephalus. This paper will provide a review of hydrocephalus with a specific focus on third ventriculostomy. Endoscopic third ventriculostomy (ETV) is an accepted treatment option for patients with obstructive hydrocephalus. At the Alberta Children's Hospit... |
2,323,842 | [Non-compaction of the left ventricle - not only in children]. | A case of a 44-year-old woman with left ventricular non-compaction which manifested in adulthood as dyspnea, fatique and NYHA class III heart failure, is described. She received treatment typical for heart failure and was offered heart transplantation and cardioverter-defibrillator implantation which she refused. Unfor... |
2,323,843 | A case report of intraventricular gliofibroma. | Gliofibroma is a rare tumor with biphasic morphology. We report a case of a 3-month-old girl presenting with increasing head circumference. CT and MRI showed the presence of a large heterogeneous, nonenhancing tumor filling the atria and bodies of the lateral ventricles with caudal extension into the third ventricle. H... |
2,323,844 | Comparison of contrast-enhanced T1-weighted FLAIR with BLADE, and spin-echo T1-weighted sequences in intracranial MRI. | We compared periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER, BLADE) MR technique with spin echo (SE) technique for evaluation of artifacts, and detection and delineation of brain lesions.</AbstractText>Contrast-enhanced T1-weighted fluid attenuated inversion recovery (FLAIR) imag... |
2,323,845 | Periostin as a heterofunctional regulator of cardiac development and disease. | Periostin (Postn) is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal ... |
2,323,846 | Distribution of kisspeptin neurones in the adult female mouse brain. | Kisspeptin-GPR54 signalling is essential for normal reproductive functioning. However, the distribution of kisspeptin neuronal cell bodies and their projections is not well established. The present study aimed to provide a detailed account of kisspeptin neuroanatomy in the mouse brain. Using a polyclonal rabbit antibod... |
2,323,847 | Intracerebral tension pneumocephalus complicating endoscopic sinus surgery: case report. | Various forms of intracranial air have been described in the literature.</AbstractText>This report aims to present clinical, radiological and intraoperative findings of a rare intracranial air entrapment case after endoscopic sinus surgery.</AbstractText> |
2,323,848 | Pigmented ependymoma with signet-ring cells and Rosenthal fibers: a rare variant of ependymoma. | We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35-year-old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arranged resembling oligode... |
2,323,849 | Transsphenoidal meningoencephalocele associated with cleft lip and palate: challenges for diagnosis and surgical treatment. | The aim of this study was to highlight the challenges for early diagnosis and the difficulties observed in surgical treatment of patients with transsphenoidal meningoencephalocele associated with cleft lip and/or palate.</AbstractText>We evaluated six male patients treated over the course of 4 years. Five patients pres... |
2,323,850 | Disturbed distribution of proliferative brain cells during lupus-like disease. | Brain atrophy and neuronal degeneration of unknown etiology are frequent and severe concomitants of the systemic autoimmune disease lupus erythematosus (SLE). Using the murine MRL/lpr model, we examined populations of proliferative brain cells during the development of SLE-like disease and brain atrophy. The disease on... |
2,323,851 | Developmental vitamin D deficiency causes abnormal brain development. | There is now clear evidence that vitamin D is involved in brain development. Our group is interested in environmental factors that shape brain development and how this may be relevant to neuropsychiatric diseases including schizophrenia. The origins of schizophrenia are considered developmental. We hypothesised that de... |
2,323,852 | Development of an accelerated GVF semi-automatic contouring algorithm for radiotherapy treatment planning. | Fast contouring is important in image-guided radiation therapy (IGRT) and adaptive radiation therapy (ART) where large computed tomography (CT) volumes have to be segmented. In this study, a modified active contour (also called snake) segmentation method based on a faster gradient-vector-flow (GVF) calculation algorith... |
2,323,853 | Prolactin induces tuberoinfundibular dopaminergic neurone differentiation in Snell dwarf mice if administered beginning at 3 days of age. | The hypothalamic tuberoinfundibular dopaminergic (TIDA) neurones secrete dopamine, which inhibits prolactin secretion. TIDA neurone numbers are deficient in Ames (df/df) and Snell (dw/dw) dwarf mice, which lack prolactin, growth hormone and thyroid-stimulating hormone. Prolactin therapy initiated before 21 days maintai... |
2,323,854 | Tissue tropism of nervous necrosis virus (NNV) in Atlantic cod, Gadus morhua L., after intraperitoneal challenge with a virus isolate from diseased Atlantic halibut, Hippoglossus hippoglossus (L.). | Atlantic cod, Gadus morhua, averaging 100 g, were experimentally challenged by intraperitoneal injection of nervous necrosis virus (NNV) originating from Atlantic halibut. Cod tissues, including blood, gill, pectoral fin, barbel, ventricle, atrium, spleen, liver, lateral line (including muscle tissue), eye (retina) and... |
2,323,855 | Health-related quality of life in long-term survivors of childhood brain tumors. | To identify predictors for health-related quality of life (HRQOL) in survivors of childhood brain tumors and its relationship to cognitive function.</AbstractText>One hundred twenty-six consecutive Danish childhood brain tumor patients treated 1970-1997 and being 7.9-40.4 years at follow-up were assessed for general in... |
2,323,856 | Motion sickness may be caused by a neurohumoral action of acetylcholine. | The mechanism by which motion stimulation results in the autonomic responses, known as motion sickness, has remained somewhat of an enigma. Neural connections between the vestibular nuclei and the autonomic and emetic centers in the brainstem have been described, but these appear to be relatively sparse. Thus, new or a... |
2,323,857 | Left ventricular radial and circumferential wall motion analysis in horses using strain, strain rate, and displacement by 2D speckle tracking. | Noninvasive assessment of left-ventricular (LV) function is clinically relevant, but is incompletely studied in horses.</AbstractText>To document the feasibility, describe the techniques, and determine the reliability of 2D speckle tracking (2DST) for characterization of LV radial and circumferential wall motion in hor... |
2,323,858 | The management of hydrocephalus in children with posterior fossa tumours: the role of pre-resectional endoscopic third ventriculostomy. | The purpose of this retrospective case series was to determine the incidence of complications and outcomes associated with a primary management policy of endoscopic third ventriculostomy (ETV) prior to posterior fossa tumour resection in a single paediatric neurosurgical unit.</AbstractText>Between July 1999 and August... |
2,323,859 | Early formation of a GFAP-positive cell population in the ventricular zone during chicken brain development. | It is believed that neurons are generated near the surface of the embryonic cerebral ventricles, whereas glial cell proliferation occurs at sites distant to the ventricles. There is still uncertainty concerning the developmental stages when glial and neuronal cell lines diverge in the proliferative zone. The purpose of... |
2,323,860 | Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. | Understanding how electrotonic loading of cardiomyocytes by unexcitable cells alters cardiac impulse conduction may be highly relevant to fibrotic heart disease. In this study, we optically mapped electrical propagation in confluent, aligned neonatal rat cardiac monolayers electrotonically loaded with cardiac fibroblas... |
2,323,861 | Anti-allodynic effect of intracerebroventricularly administered antioxidant and free radical scavenger in a mouse model of orofacial pain. | To evaluate possible effects of the intracerebroventricular (icv) injection of either O-Tricyclo [5.2.1.0(2,6)] dec-9-yl dithiocarbonate potassium salt (D609), a potent antioxidant and inhibitor of phosphatidylcholine specific phospholipase C (PtdCho-PLC) and acid sphingomyelinase (ASMase), or the spin trap/free radica... |
2,323,862 | [Hydrocephaly in newborns with perinatal brain damage of moderate severity].<Pagination><StartPage>9</StartPage><EndPage>12</EndPage><MedlinePgn>9-12</MedlinePgn></Pagination><Abstract><AbstractText>A prospective examination of 103 newborns with hypoxic damage of the central nervous system of moderate severity was cond... | A prospective examination of 103 newborns with hypoxic damage of the central nervous system of moderate severity was conducted on the 4-7, 10-14 and 21-28 days after birth and included clinical examination, neurosonographic study with dopplerography of great brain arteries and biochemical study of venous blood and urin... |
2,323,863 | A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin. | We recently showed that leptin has powerful central nervous system (CNS)-mediated antidiabetic and cardiovascular actions. This study tested whether the CNS melanocortin system mediates these actions of leptin in diabetic rats.</AbstractText>A cannula was placed in the lateral ventricle of Sprague-Dawley rats for intra... |
2,323,864 | Haptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic mice. | We have recently demonstrated in man that a functional allelic polymorphism in the Haptoglobin (Hp) gene plays a major role in determining survival and congestive heart failure after myocardial infarction (MI). We sought to recapitulate the effect of Hp type on outcomes and cardiac remodeling after MI in transgenic mic... |
2,323,865 | Divergent regulation of hypothalamic neuropeptide Y and agouti-related protein by photoperiod in F344 rats with differential food intake and growth. | Hypothalamic genes involved in food intake and growth regulation were studied in F344 rats in response to photoperiod. Two sub-strains were identified: F344/NHsd (F344/N) and F344/NCrHsd (F344/NCr); sensitive and relatively insensitive to photoperiod respectively. In F344/N rats, marked, but opposite, changes in the ge... |
2,323,866 | Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. | In the mammalian brain, neural stem and progenitor cells in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus generate new neurons throughout adulthood. The generation of new functional neurons is a complex process that is tightly controlled by extrinsic signals and that is... |
2,323,867 | Three-dimensional reconstructive analysis of intracytoplasmic lumina found in ependymomas. | Three-dimensional reconstructive analyses revealed that the intracytoplasmic lumina found in ependymomas were actually formed by subsidence of an extracellular membrane, resembling a volcano. This finding was compatible with cytologic and electron microscopic findings. In addition, there were many tiny thorns resemblin... |
2,323,868 | [Inhibiting effects of interleukin-10 on expression of E-selectin and L-selectin in cerebral ischemia-reperfusion: experiment with rats]. | To investigate the inhibiting effects of interleukin-10 (IL-10) on the expression of E-selectin and L-selectin in cerebral ischemia-reperfusions.</AbstractText>Seventy-two adult male Sprague-Dawley rats were randomly divided into 4 equal groups, cerebral ischemia-reperfusion (I/R) group undergoing middle cerebral arter... |
2,323,869 | Comparison of MRI signatures in pattern I and II multiple sclerosis models. | The majority of individuals with multiple sclerosis (MS) exhibit T-cell- and macrophage-dominated lesions (patterns I and II; as opposed to III and IV). These lesions, in turn, may be distinguished on the basis of whether or not there are immunoglobulin and complement depositions at the sites of active myelin destructi... |
2,323,870 | First trimester neurosonoembryology with automated follicle tracking: preliminary findings. | We evaluated the feasibility of demonstration of the embryonic cerebral ventricles using three dimensional transvaginal ultrasonography and software which has been developed to automatically calculate the volume of ovarian follicles after ovarian stimulation. In four out of six subsequent ultrasound examinations which ... |
2,323,871 | [Noncompaction of the left ventricular myocardium]. | Noncompaction of the left ventricular myocardium is recently described as a cause of left ventricular dysfunction. In the article, we describe epidemiological and clinical aspects of this condition, which presents clinically at any age.</AbstractText>This article is based on a review of articles from our own literature... |
2,323,872 | Multifocal complex glioneuronal tumor in an elderly man: an autopsy study: case report. | The clinicopathological spectra of a dysembryoplastic neuroepithelial tumor (DNT) and a rosette-forming glioneuronal tumor (RGNT) are expanding. We report here the autopsy findings of a case of complex glioneuronal tumor with combined histological features of both a DNT and an RGNT.</AbstractText>A 79-year-old man pres... |
2,323,873 | Longitudinal pattern of regional brain volume change differentiates normal aging from MCI. | Neuroimaging measures have potential as surrogate markers of disease through identification of consistent features that occur prior to clinical symptoms. Despite numerous investigations, especially in relation to the transition to clinical impairment, the regional pattern of brain changes in clinically normal older adu... |
2,323,874 | Diffuse leptomeningeal glioneuronal tumors: a new entity? | The peculiar radiological and pathological findings of four pediatric cases admitted to the University Hospital of Padua between 1990 and 2007 are described. In all cases, the contrast-enhanced head and spine magnetic resonance images revealed thickened and abnormally enhancing subarachnoid spaces particularly at the l... |
2,323,875 | Enlarged thalamostriate vein causing unilateral Monro foramen obstruction. Case report. | Causes of unilateral hydrocephalus resulting from an obstruction at the Monro foramen include foraminal atresia, tumors, gliosis, contralateral shunting, and infectious and inflammatory conditions. However, few reports in the literature cite vascular lesions as the cause of the obstruction. To their knowledge, the auth... |
2,323,876 | Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. | Dysembryoplastic neuroepithelial tumors (DNETs) are frequently seen in children and young adults with intractable epilepsy, and are typically located in the temporal cortex. Extracortical location of DNET is a very rare occurrence. The authors report on a child with a unique extracortical location of DNET with an exten... |
2,323,877 | Cell swelling, impulse conduction, and cardiac arrhythmias in the failing heart. Opposite effects of angiotensin II and angiotensin (1-7) on cell volume regulation. | The influence of hypotonic solution on cell volume and electrophysiology properties of the failing heart of cardiomyopathic hamsters (TO-2) was investigated. The results showed an increase in cell volume of quiescent isolated ventricular myocytes by 66% within 30 min. Angiotensin (1-7) [Ang (1-7)] (10(-8) M) administer... |
2,323,878 | Isolated left ventricular noncompaction diagnosed by transthoracic threedimensional echocardiography. | A 55-year-old man was admitted to our hospital because of chest distress, associated with activity. Two-dimensional echocardiography (2DE) demonstrated a suspected trabeculation versus false tendon of the left ventricular apex cordis but not meeting the diagnostic criteria of noncompaction of the ventricular myocardium... |
2,323,879 | Successful defibrillator lead remnant extraction from right ventricle using a steerable transseptal sheath and a basket retriever. | We present a case of a 73-year-old man with implantable cardioverter-defibrillator pocket erosion and Staphylococcus aureus infection who was admitted to our hospital for lead extraction. During the mechanical extraction procedure, the 12-year-old lead broke and the distal coil was trapped in the right ventricle. After... |
2,323,880 | Functional outcome at school age of preterm infants with periventricular hemorrhagic infarction. | Our objective was to determine motor, cognitive, and behavioral outcome at school age in preterm children with periventricular hemorrhagic infarction and to identify cerebral risk factors for adverse outcome.</AbstractText>This was a prospective cohort study of all preterm infants who were <37 weeks' gestation, had ... |
2,323,881 | Chemokines and cardiac fibrosis. | Several members of the chemokine family play an important role in reparative fibrosis and are involved in the pathogenesis of remodeling following myocardial infarction. Chemokines may regulate the fibrotic process through recruitment and activation of mononuclear cell subsets and fibroblast progenitors (fibrocytes), b... |
2,323,882 | Diffuse craniospinal metastases of intraventricular rhabdoid papillary meningioma with glial fibrillary acidic protein expression: a case report. | Rhabdoid papillary meningioma is a recently described clinically aggressive variant of meningiomas with a high recurrence rate. Additionally, only one case of intraventricular rhabdoid meningioma has been reported so far. We present a case of a 50-year-old man who developed an intracranial tumor of the left lateral ven... |
2,323,883 | A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. | CXCL12/CXCR4 signaling may be involved in tumor growth and angiogenesis, and homing of cancer cells to bone and other organs. Our purpose was to determine whether inhibition of CXCR4 with a peptide-based antagonist would reduce tumor growth and metastasis of breast cancer.</AbstractText>We used two mouse models of brea... |
2,323,884 | Delayed and chronic treatment with growth hormone after endothelin-induced stroke in the adult rat. | We investigated the effects of a neurorestorative treatment paradigm using long-term, central delivery of growth hormone (GH) starting 4 days after stroke. It has been shown previously that a neural GH axis is activated after stroke, that GH is neuroprotective, and can have direct trophic actions on neurons and stem ce... |
2,323,885 | Identification of brain target neurons using a fluorescent conjugate of corticotropin-releasing factor. | Corticotropin-releasing factor (CRF) is a peptide well known for its role in coordinating various neuroendocrine, autonomic, and behavioral components of the vertebrate stress response, including rapid enhancement of locomotor activity. Although CRF's locomotor enhancing properties are well documented, the neuronal mec... |
2,323,886 | Time course and nature of brain atrophy in the MRL mouse model of central nervous system lupus. | Similar to patients with systemic lupus erythematosus, autoimmune MRL/lpr mice spontaneously develop behavioral deficits and pathologic changes in the brain. Given that the disease-associated brain atrophy in this model is not well understood, the present study was undertaken to determine the time course of morphometri... |
2,323,887 | NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. | The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin. The interplay between these factors and their downstream targets are not completely understood. Here, we studied regulation of beta-catenin a... |
2,323,888 | Left ventricular infarct size assessed with 0.1 mmol/kg of gadobenate dimeglumine correlates with that assessed with 0.2 mmol/kg of gadopentetate dimeglumine. | To determine myocardial infarct (MI) size during cardiovascular magnetic resonance at 1.5 Tesla using 0.1 mmol/kg body weight of gadobenate dimeglumine (Gd-BOPTA) and 0.2 mmol/kg body weight of gadopentetate dimeglumine (Gd-DTPA).</AbstractText>Twenty participants (16 men, 4 women), aged 58 +/- 12 years, with a prior c... |
2,323,889 | Protein synthesis is essential not only for consolidation but also for maintenance and post-retrieval reconsolidation of acrobatic motor skill in rats. | It has been reported that consolidation of motor skill, a type of non-declarative memories, requires protein synthesis, as hippocampus-dependent declarative memory does. However, little is known about the importance of protein synthesis in maintenance and especially post-retrieval reconsolidation of acrobatic motor ski... |
2,323,890 | Toxic effect of blood components on perinatal rat subventricular zone cells and oligodendrocyte precursor cell proliferation, differentiation and migration in culture. | The germinal matrix of human brain gives rise to oligodendrocytes and astrocytes after mid-gestation. Hemorrhage in the germinal matrix of premature infants is associated with suppressed cell proliferation. We hypothesize that soluble blood constituents have an adverse effect on the proliferation of cultured rat subven... |
2,323,891 | Fetal hydrocephalus caused by cryptic intraventricular hemorrhage. | Cryptic intracerebral hemorrhage as an etiological factor in fetal hydrocephalus has been postulated but not described at autopsy. Four fetuses with overt hydrocephalus diagnosed by in utero ultrasound examination were examined at autopsy at 19-22 weeks gestation. Although a hemorrhagic etiology was not evident on ultr... |
2,323,892 | Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. | Cerebral ischemia can activate endogenous reparative processes, such as proliferation of endogenous neural progenitor cells (NPCs) in the subventricular zone (SVZ). Most of these new cells die shortly after injury. The purpose of this study was to examine a novel strategy for treatment of stroke at 1 week after injury ... |
2,323,893 | High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. | Medial temporal lobe (MTL) atrophy is associated with increased risk for conversion to Alzheimer disease, but manual tracing techniques and even semiautomated techniques for volumetric assessment are not practical in the clinical setting. In addition, most studies that examined MTL atrophy in Alzheimer disease have foc... |
2,323,894 | Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors. | Cocaine- and amphetamine-regulated transcript (CART) peptides are widely distributed throughout the neuraxis, including regions associated with energy balance. CART's classification as a catabolic neuropeptide is based on its inhibitory effects on feeding, coexpression with arcuate nucleus proopiomelanocortin neurons, ... |
2,323,895 | Endoscopic biopsy of foramen of Monro and third ventricle lesions guided by frameless neuronavigation: usefulness and limitations. | To describe our institution experience regarding the usefulness and limitations of frameless neuronavigation in the endoscopic biopsy of foramen of Monro and third ventricle lesions.</AbstractText>We report our experience with 22 patients harbouring intraventricular lesions located in the region of the foramen of Monro... |
2,323,896 | Neuroinvasion in sheep transmissible spongiform encephalopathies: the role of the haematogenous route. | It is generally believed that after oral exposure to transmissible spongiform encephalopathy (TSE) agents, neuroinvasion occurs via the enteric nervous system (ENS) and the autonomic nervous system. As a result, the dorsal motor nucleus of the vagus nerve is the initial point of disease-associated prion protein (PrP(d)... |
2,323,897 | Whole-organ perfusion of the pancreas using dynamic volume CT in patients with primary pancreas carcinoma: acquisition technique, post-processing and initial results. | The purpose of this study was to evaluate a whole-organ perfusion protocol of the pancreas in patients with primary pancreas carcinoma and to analyse perfusion differences between normal and diseased pancreatic tissue. Thirty patients with primary pancreatic malignancy were imaged on a 320-slice CT unit. Twenty-nine ca... |
2,323,898 | The role of the choroid plexus in neutrophil invasion after traumatic brain injury. | Traumatic brain injury (TBI) frequently results in neuroinflammation, which includes the invasion of neutrophils. After TBI, neutrophils infiltrate the choroid plexus (CP), a site of the blood-cerebrospinal fluid (CSF) barrier (BCSFB), and accumulate in the CSF space near the injury, from where these inflammatory cells... |
2,323,899 | Ionic mechanisms underlying action potential prolongation by focal cerebral ischemia in rat ventricular myocytes. | Despite prolongation of the QTc interval in humans during cerebral ischemia, little is known about the mechanisms that underlie these actions. Cerebral ischemic model was established by middle cerebral artery occlusion (MCAO) for 24 h. In rat ventricular myocytes, the effect of cerebral ischemia on action potential dur... |
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