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2,323,900 | Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year. | Measurement of volumetric changes with MR might be a useful surrogate endpoint for clinical trials in frontotemporal lobar degeneration (FTLD). Because there is only limited longitudinal imaging data currently available, we measured the rate of change over 1 year of whole brain volume (WBV) and ventricular volume (VV) ... |
2,323,901 | [Neurogenesis in the subventricular zone of neonatal rats after ischemic brain injury]. | To study the proliferation and differentiation of neural stem cells in the subventricular zone (SVZ) in neonatal rats after bilateral common arteries occlusion.</AbstractText>Ninety-six 3-day-old Sparuge-Dawley rats were randomly divided into two groups: ischemia and control. Rats in the ischemia group were subjected t... |
2,323,902 | Adult hippocampal neurogenesis and related neurotrophic factors. | New neurons are continually generated in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles of the adult brain. These neurons proliferate, differentiate, and become integrated into neuronal circuits, but how they are involved in brain function remains unknown. A deficit o... |
2,323,903 | Modeling of cardiac ischemia in human myocytes and tissue including spatiotemporal electrophysiological variations. | Cardiac tissue exhibits spatially heterogeneous electrophysiological properties. In cardiac diseases, these properties also change in time. This study introduces a framework to investigate their role in cardiac ischemia using mathematical modeling and computational simulations at cellular and tissue level. Ischemia was... |
2,323,904 | Laparoscopic removal of a foreign body in the pelvic cavity through one port using a flexible cholangioscope. | More than two trocar ports 12 mm in diameter were usually used to remove a foreign body from the peritoneal cavity using laparoscopic surgery. We designed a method of laparoscopic removal through a single port 5 mm in diameter and a flexible cholangioscope.</AbstractText>The patient had a ventriculoperitoneal shunt (V-... |
2,323,905 | Familial amyloid polyneuropathy: a clinico-pathologic study. | In familial amyloid polyneuropathy (FAP), destruction of nerve fibres is related to accumulation of mutated transthyretin (mTTR) derived amyloid deposits (AD) in the endoneurium. Liver transplantation (LT), which removes the main source of mTTR, does not prevent deterioration of the clinical condition in all recipients... |
2,323,906 | Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance P contain vesicular glutamate transporter 3 (VGLUT3). | The serotonergic dorsal raphe nucleus (DR) is an area enriched with cell bodies and axons containing the third vesicular glutamate transporter, VGLUT3. However, the role of VGLUT3-containing axons in modulating activity of serotonin (5-HT) neurons within the DR remains poorly understood. In this study, neurochemical fe... |
2,323,907 | Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. | 2,5-Hexanedione (HD), a metabolite of n-hexane, causes central and peripheral neuropathy leading to motor neuron deficits. Although chronic exposure to n-hexane is known to cause gradual sensorimotor neuropathy, there are no reports on the effects of low doses of HD on neurogenesis in the central nervous system. In the... |
2,323,908 | Validation of Abeta1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease. | Valid animal models for a specific human disease are indispensable for development of new therapeutic agents. The conclusions drawn from animal models largely depend on the validity of the model. Several studies have shown that administration of Abeta into the brain causes some of the pathological events observed in Al... |
2,323,909 | The anatomical location of the arcuate fasciculus in the human brain: a diffusion tensor tractography study. | Little is known about the detailed anatomical location of the arcuate fasciculus (AF) in the human brain, which could easily be applied for use in the management of patients with aphasia. In the current study, we attempted to describe the anatomy of the AF location in the normal human brain using diffusion tensor tract... |
2,323,910 | Expression and localization of the Parkin co-regulated gene in mouse CNS suggests a role in ependymal cilia function. | Parkin Co-Regulated Gene (PACRG) is a gene that shares a bi-directional promoter with the Parkinson's disease associated gene parkin. The functional role of PACRG is not well understood, although the gene has been associated with parkinsonian syndromes and more recently with eukaryotic cilia and flagella. We investigat... |
2,323,911 | [Echocardiography and magnetic resonance tomography of the heart in diagnosis of noncompaction of left ventricular myocardium]. | Left ventricular (LV) noncompaction (NC) is a rare form of cardiomyopathy which initially was diagnosed by transthoracic echocardiography (EchoCG). This paper presents description of 15 patients with diagnosis of LVNC. Aim of the study was to compare results of EchoCG with data of magnetic resonance tomography (MRT) of... |
2,323,912 | The expression pattern of the 70-kDa heat shock protein Hspa2 in mouse tissues. | The highest expression level of a 70-kDa heat shock protein family member Hspa2 is detected specifically in meiotic and post-meiotic male germ cells, which is reflected by original name of this protein, i.e., testis-specific Hsp70. However, this chaperon protein could be also detected in certain somatic tissues. Here, ... |
2,323,913 | Sonographic findings in severe fetomaternal transfusion. | Fetomaternal hemorrhage (FMH) or fetomaternal transfusion syndrome is the leakage of fetal red blood cells into the maternal circulation. Massive FMH can cause substantial fetal morbidity and mortality. Sonographic evidence of severe FMH syndrome includes fetal hydrops and other fetal anemia-related findings. The peak ... |
2,323,914 | Dilation of the olfactory bulb cavity concurrent with hydrocephalus in four small breed dogs. | Four small breed dogs were admitted with seizures. Magnetic resonance imaging (MRI) of the brain revealed dilation of the olfactory bulb cavity as well as enlargement of the lateral ventricles. These findings demonstrate that dilation of the olfactory bulb cavity can occur concurrent with hydrocephalus. This is the fir... |
2,323,915 | Changes in aqueductal CSF stroke volume in shunted patients with idiopathic normal-pressure hydrocephalus. | Aqueductal CSF stroke volume (ACSV) measured by phase-contrast MR imaging is a tool for selection of surgical patients with idiopathic normal-pressure hydrocephalus (iNPH). The aim of the present study was to investigate whether there is a relationship between clinical outcome and changes in ACSV in patients with iNPH ... |
2,323,916 | Characterization of juvenile and young adult mice following induction of hydrocephalus with kaolin. | Hydrocephalus is a common neurological problem in humans, usually caused by an impairment of cerebrospinal fluid (CSF) flow or absorption. A reliable induced model of chronic hydrocephalus in mice would be useful to test hypotheses using genetic mutants. Our goal was to characterize behavioral and histological changes ... |
2,323,917 | Development of the area postrema: an immunohistochemical study in the macaque. | The organization and chemical development of the area postrema (AP) in the macaque monkey was studied by immunohistochemistry imaged with conventional and confocal microscopy from day 40 of gestation to adulthood. The thin ependyma of the adult was found to develop from a thick continuous structure beginning in the sec... |
2,323,918 | Successful treatment of multidrug-resistant Acinetobacter baumannii ventriculitis with intravenous and intraventricular colistin.<Pagination><StartPage>141</StartPage><EndPage>147</EndPage><MedlinePgn>141-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1179/146532809X440761</ELocationID><Abstract><... | Management of multidrug-resistant Acinetobacter baumannii (MDRAB) meningitis/ventriculitis is a difficult therapeutic problem owing to the limited penetration of antibiotics into cerebrospinal fluid (CSF). A 2-month-old girl with ventriculitis caused by MDRAB is reported. Despite therapy with intravenous (IV) colistin ... |
2,323,919 | Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages. | Neurons in the macaque brain arise from progenitors located near the cerebral ventricles in a temporally segregated manner such that lethal doses of ionizing irradiation, if administered over a discrete time interval, can deplete individual nuclei selectively. A previous study showed that neuron number in the dorsal la... |
2,323,920 | An ultrasound study of brain tissue biomechanics in patients following craniectomy. | So far, little attention has been paid to the biomechanical aspects of decompressive craniectomy. The brain tissue deformation occurring in these patients is difficult to quantify. Twenty-six patients suffering from a large bone defect after craniectomy were examined in supine position. The third ventricle's axial diam... |
2,323,921 | Free-breathing MRI for the assessment of myocardial infarction: clinical validation. | The objective of our study was to validate free-breathing 2D inversion recovery delayed-enhancement MRI for the assessment of myocardial infarction compared with a breath-hold 3D technique.</AbstractText>Institutional review board approval and written informed consent were obtained. Thirty-two patients (25 men, seven w... |
2,323,922 | Solving the coupled system improves computational efficiency of the bidomain equations. | The bidomain equations are frequently used to model the propagation of cardiac action potentials across cardiac tissue. At the whole organ level, the size of the computational mesh required makes their solution a significant computational challenge. As the accuracy of the numerical solution cannot be compromised, effic... |
2,323,923 | Persistent migration of neuroblasts from the subventricular zone to the injured striatum mediated by osteopontin following intracerebral hemorrhage. | We investigated intracerebral hemorrhage (ICH)-induced lateral migration of neuroblasts and the mechanism underlying this migration. ICH model was induced by collagenase injection into the striatum of adult wild-type and osteopontin (OPN) knockout mice. In the wild-type mice, the lateral migration of neuroblasts from t... |
2,323,924 | The quality of preterm infants' spontaneous movements: an early indicator of intelligence and behaviour at school age. | The quality of very preterm infants' spontaneous movements at 11 to 16 weeks post-term age is a powerful predictor of their later neurological status. This study investigated whether early spontaneous movements also have predictive value for the intellectual and behavioural problems that children born very preterm ofte... |
2,323,925 | Obstructive sleep apnea: a cardiopulmonary perspective and medical therapeutics. | The clinical importance of obstructive sleep apnea (OSA) is gradually rising to the extent that many clinicians now consider OSA as an underlying etiology or precipitating factor for many cardiovascular and pulmonary events. Although the incidence and pathophysiology underlying these cardiopulmonary structural and func... |
2,323,926 | Comparison of diffusion tensor-based tractography and quantified brain atrophy for analyzing demyelination and axonal loss in MS. | We combined diffusion tensor imaging (DTI) measures of the corpus callosum (CC) and the superior longitudinal fascicle (SLF) with calculation of brain atrophy in 53 patients with relapsing-remitting multiple sclerosis (MS) and 15 healthy controls, to analyze their interrelation and their correlation with disease durati... |
2,323,927 | Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect. | Neural migration defects lead to various types of human malformations of cortical development including subcortical band heterotopia, which shows formation of a secondary cortical plate beneath the primary cortex and is typically caused by mutation of the DCX (doublecortin) gene. Subcortical band heterotopia is usually... |
2,323,928 | Social isolation modulates corticotropin-releasing factor type 2 receptor, urocortin 1 and urocortin 2 mRNAs expression in the cardiovascular system of prairie voles. | The purpose of the present study was to examine the effect of social isolation stress on the expression of messengers ribonucleic acid (mRNAs) for corticotropin-releasing factor receptor type 2 (CRF2 receptor), urocortin 1 (Ucn 1) and urocortin 2 (Ucn 2) in the cardiovascular system of female and male prairie voles (Mi... |
2,323,929 | The effects of prenatal alcohol exposure on the morphological characteristics of spinal motoneurons. | Clinical studies and research in animals have established that alcohol consumption during pregnancy produces irreversible developmental anomalies. Deficits in fine motor performance are often noted in infants diagnosed with fetal alcohol syndrome. However, the effects of alcohol on the spinal motoneurons have not been ... |
2,323,930 | Technical considerations of endoscopic septostomy using a biportal approach in a case of hydrocephalus associated with tuberous sclerosis. | We report herein the technical considerations for endoscopic septostomy in a case of hydrocephalus associated with tuberous sclerosis.</AbstractText>A 17-year-old boy presented with visual and gait disturbances. Computed tomography revealed an intraventricular mass obstructing the foramen of Monro bilaterally and marke... |
2,323,931 | Automatic segmentation of the human brain ventricles from MR images by knowledge-based region growing and trimming. | Automatic segmentation of the human brain ventricular system from MR images is useful in studies of brain anatomy and its diseases. Existing intensity-based segmentation methods are adaptive to large shape and size variations of the ventricular system, but may leak to the non-ventricular regions due to the non-homogene... |
2,323,932 | Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. | This study describes a young girl who presented with involuntary weight loss, spontaneous vomiting and behavioural change. Imaging confirmed hypothalamic and brainstem involvement. Routine investigations (including cerebrospinal fluid analysis and neuromyelitis optica IgG) were unhelpful. Biopsy of the hypothalamic les... |
2,323,933 | Sudden death due to a colloid cyst of the third ventricle: report of three cases with a special sign at autopsy. | Colloid cysts of the third ventricle are rare benign cysts but they may be potentially life-threatening. Three cases of sudden death resulting from colloid cysts of the third ventricle are presented. The first and second cases were treated for migraine headaches. In the first case, the patient was a 24-year-old woman w... |
2,323,934 | Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus. | To develop a model to predict the probability of endoscopic third ventriculostomy (ETV) success in the treatment for hydrocephalus on the basis of a child's individual characteristics.</AbstractText>We analyzed 618 ETVs performed consecutively on children at 12 international institutions to identify predictors of ETV s... |
2,323,935 | Brains of apolipoprotein E deficient mice fed vitamin E deficient diets show alteration in handling alpha tocopherol injected into the cerebral ventricles. | Abnormal function of apolipoprotein E (apoE) has been implicated in the incidence of some neurological disorders including dementia. Our recent experiments have shown that apoE deficiency alters the dynamics of alpha tocopherol (vitamin E) handling by brain. In the current investigation, we examined the uptake and rete... |
2,323,936 | Intraventricular Malignant Meningioma with CSF-Disseminated Spinal Metastasis : Case Report and Literature Review. | The authors report a case of 42-year-old woman with an intraventricular tumor in the trigone of the left lateral ventricle. The first operation achieved a microscopically complete resection. The tumor was histologically atypical meningioma. After 26 months, there were recurrences of intraventricular meningioma. Complet... |
2,323,937 | Neonatal co-lesion by DSP-4 and 5,7-DHT produces adulthood behavioral sensitization to dopamine D(2) receptor agonists. | To assess the possible modulatory effects of noradrenergic and serotoninergic neurons on dopaminergic neuronal activity, the noradrenergic and serotoninergic neurotoxins DSP-4 N-(2-chlorethyl)-N-ethyl-2-bromobenzylamine (50.0 mg/kg, sc) and 5,7-dihydroxytryptamine (5,7-DHT) (37.5 microg icv, half in each lateral ventri... |
2,323,938 | Role of the T-type calcium channel CaV3.2 in the chronotropic action of corticosteroids in isolated rat ventricular myocytes. | The mineralocorticoid receptor is involved in the development of several cardiac dysfunctions, including lethal ventricular arrhythmias associated with heart failure or hyperaldosteronism, but the molecular mechanisms responsible for these effects remain to be clarified. Reexpression of low voltage-activated T-type cal... |
2,323,939 | A case of Gerstmann-Sträussler-Scheinker syndrome with the P105L prion protein gene mutation presenting with ataxia and extrapyramidal signs without spastic paraparesis. | We describe the clinical features of a patient with Gerstmann-Sträussler-Scheinker syndrome with a mutation in the prion protein gene at codon 105 (GSS105) who presented with ataxia. Neurologic examination showed memory disturbance, dysarthria, extrapyramidal signs (bradykinesia and resting tremor) and ataxic gait... |
2,323,940 | Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain. | Exogenously delivered butyrylcholinesterase (BChE) has proven to be an efficient bioscavenger against highly toxic organophosphorus poisons and nerve agents. The scavenger properties of BChE when delivered via intramuscular, intravenous, subcutaneous, or intraperitoneal routes are limited to the body's peripheral sites... |
2,323,941 | Maternal dietary n-3 fatty acids alter cardiac ventricle fatty acid composition, prostaglandin and thromboxane production in growing chicks. | The effects of feeding n-6 and n-3 fatty acids to broiler hens on cardiac ventricle fatty acid composition, and prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) production of hatched chicks were investigated. Fertile eggs obtained from hens fed diets supplemented with 3.5% sunflower oil (Low n-3), 1.75% sunflower+1.75... |
2,323,942 | [The effect of the duration of corpse immersion on the occurrence of selected morphological findings]. | The report presents a method of estimation the duration of corpse immersion based on fully developed morphological findings. The authors demonstrated that the duration of body immersion affects the occurrence of marked putrid color, separation of hair, the "washerwoman's skin" effect on the macerated fingertips, separa... |
2,323,943 | Normal and abnormal anatomy of the cerebellar vermis in midgestational human fetuses. | Evaluation of the cerebellar vermis is an important component of fetal autopsy, but lack of an established approach, inadequate normal anatomic data, and the subtle nature of some cerebellar malformations negatively affect concordance between prenatal ultrasound and autopsy diagnoses.</AbstractText>Gross anatomy and sa... |
2,323,944 | Executive dysfunction and periventricular diffusion tensor changes in amnesic mild cognitive impairment and early Alzheimer's disease. | Our aim in this study was to explore the neural substrates of executive function in frontal and nonfrontal white matter using diffusion tensor imaging (DTI). We studied the relationship between executive dysfunction and DTI measurements on 13 subjects with amnesic mild cognitive impairment (aMCI), 11 subjects with earl... |
2,323,945 | Subependymomas of the lateral ventricle: tumor recurrence correlated with increased Ki-67 labeling index. | Subependymomas of the lateral ventricles are rare tumors. We present two patients with subependymomas of the lateral ventricle, who underwent gross total resection of the tumor via transcallosal approach. The patient, with increased Ki-67 labeling index had recurrence of tumor two years after the initial operation. We ... |
2,323,946 | Incidence and pattern of intraoperative hemodynamic response to endoscopic third ventriculostomy. | In patients undergoing endoscopic third ventriculostomy (ETV), various cardiovascular changes occur in the intraoperative period.</AbstractText>We tried to determine a pattern in these changes and their relation to different surgical steps.</AbstractText>A total of 260 patients were studied over a period of six years. ... |
2,323,947 | Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche. | In the adult CNS, neurogenesis takes place in special niches. It is not understood how these niches are formed during development and how they are maintained. In contrast to mammals, stem cell niches are abundant in zebrafish and also found in other parts of the brain than telencephalon. To understand common characteri... |
2,323,948 | Cardiac cell therapy: overexpression of connexin43 in skeletal myoblasts and prevention of ventricular arrhythmias. | Cell-based therapies have great potential for the treatment of cardiovascular diseases. Recently, using a transgenic mouse model Roell et al. reported that cardiac engraftment of connexin43 (Cx43)-overexpressing myoblasts in vivo prevents post-infarct arrhythmia, a common cause of death in patients following heart atta... |
2,323,949 | Incremental value of live/real time three-dimensional transthoracic echocardiography in the assessment of right ventricular masses. | This case series demonstrates the incremental value of three-dimensional transthoracic echocardiography (3D TTE) over two-dimensional transthoracic echocardiography (2D TTE) in the assessment of 11 patients with right ventricular (RV) masses or mass-like lesions (three cases of RV thrombus, one myxoma, one fibroma, one... |
2,323,950 | Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse. | The migratory behavior of neuroblasts after a stroke is poorly understood. Using time-lapse microscopy, we imaged migration of neuroblasts and cerebral vessels in living brain slices of adult doublecortin (DCX, a marker of neuroblasts) enhanced green fluorescent protein (eGFP) transgenic mice that were subjected to 7 d... |
2,323,951 | GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. | A subset of neoplastic cells within human high-grade gliomas has features associated with stem cells. These cells may sustain glioma growth, and their stem-like properties may confer resistance to standard glioma treatments. Whether glioma stem cells derive from indigenous neural stem cells (NSC), or from tumor cells t... |
2,323,952 | Improving the role of intraventricular antimicrobial agents in the management of meningitis. | The aim is to review the role of intraventricular administration of antimicrobial agents in the treatment of patients with bacterial and fungal meningitis.</AbstractText>This article discusses indications for intraventricular antimicrobial agents, choice of antibiotics, strategies to monitor pharmacokinetics of central... |
2,323,953 | The use of high-frequency jet ventilation for removal of obstructing casts in patients with plastic bronchitis. | To describe improved cast removal with short periods of high-frequency jet ventilation (HFJV) in patients with single ventricle physiology.</AbstractText>Case report.</AbstractText>Pediatric cardiac intensive care unit.</AbstractText>Two patients with plastic bronchitis during prolonged stay in a intensive care unit af... |
2,323,954 | Dynamic changes of striatal and extrastriatal abnormalities in glutaric aciduria type I. | In glutaric aciduria type I, an autosomal recessive disease of mitochondrial lysine, hydroxylysine and tryptophan catabolism, striatal lesions are characteristically induced by acute encephalopathic crises during a finite period of brain development (age 3-36 months). The frequency of striatal injury is significantly l... |
2,323,955 | Ectopic presacral choroid plexus cyst in a neonate. | An unusual case of a presacral ectopic choroid plexus cyst in a neonate is described. After birth, a soft lump was noticed at the left buttock. Imaging studies including sonography and magnetic resonance imaging demonstrated a presacral cystic lesion extending to the buttocks, composed of several septated cystic masses... |
2,323,956 | Localization of serotoninergic neurons that participate in regulating diaphragm activity in the cat. | Although a considerable body of literature indicates that serotoninergic neurons affect diaphragm activity both through direct inputs to phrenic motoneurons and multisynaptic connections involving the brainstem respiratory groups, the locations of the serotoninergic neurons that modulate breathing have not been well de... |
2,323,957 | Transcallosal transbiforaminal approach to the third ventricle. | Colloid cysts are benign intracranial lesions but can show signs of severe obstructive hydrocephalus and present with sudden death. The approaches to colloid cysts have been described by many authors. The treatment modalities can be classified as endoscopic and microsurgical. Bilateral access through the foramen is com... |
2,323,958 | Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. | Antipsychotic drug perphenazine belongs to the phenothiazine group commonly reported to induce ECG changes and tachyarrhythmias. Data about its effect on ionic membrane currents in cardiomyocytes are missing. We analyzed the effect of perphenazine (0.1-100 microM) on fast sodium current I (Na) and transient outward pot... |
2,323,959 | Outcomes in neonates with pulmonary atresia and intact ventricular septum underwent pulmonary valvulotomy and valvuloplasty using a flexible 2-French radiofrequency catheter.<Pagination><StartPage>245</StartPage><EndPage>251</EndPage><MedlinePgn>245-51</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.... | The penetrating cardiac injury after the chest stab wound in 33 year old patient is described. The following clinical signs indicated suspected cardiac injury: localization of injury to the region of the heart, the signs of acute bleeding and cardiac tamponade, which was also confirmed by echocardiography. During urgen... |
2,323,960 | Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area. | Neuroinflammation plays an important role in the progression of Alzheimer's disease (AD) and is characterized by the presence of activated microglia. We investigated whether chronic neuroinflammation affects the induction of N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) and NMDAR-independ... |
2,323,961 | Selective upregulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche. | In the adult rodent brain, constitutive neurogenesis occurs in two restricted regions, the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone of the hippocampal dentate gyrus, where multipotent neural stem/progenitor cells generate new neurons. Using Western blotting and immunohistochemistry fo... |
2,323,962 | Periventricular white matter damage in the hypoxic neonatal brain: role of microglial cells. | Periventricular white matter damage (PWMD) also known as periventricular white matter injury, is one of the major causes of neurological impairment in premature newborns. The etiology of white matter injury is multifaceted with hypoxia-ischemia being an important underlying factor. The developing oligodendrocytes are s... |
2,323,963 | Real time analysis of pontine neurons during initial stages of nucleogenesis. | During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in ... |
2,323,964 | Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. | The potential neuroprotective role of sex hormones in chronic neurodegenerative disorders and acute brain ischemia following cardiac arrest and stroke is of a great therapeutic interest. Long-term pretreatment with estradiol and other estrogens affords robust neuroprotection in male and female rodents subjected to foca... |
2,323,965 | The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin. | Planar cell polarity (PCP) is a property of epithelial tissues where cellular structures coordinately orient along a two-dimensional plane lying orthogonal to the axis of apical-basal polarity. PCP is particularly striking in tissues where multiciliate cells generate a directed fluid flow, as seen, for example, in the ... |
2,323,966 | Bone marrow stem cells implantation with alpha-cyclodextrin/MPEG-PCL-MPEG hydrogel improves cardiac function after myocardial infarction. | Cellular transplantation represents a promising therapy for myocardial infarction (MI). However, it is limited by low transplanted cell retention and survival within the ischemic tissue. This study was designed to investigate whether injectable alpha-cyclodextrin/poly(ethylene glycol)-b-polycaprolactone-(dodecanedioic ... |
2,323,967 | Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease. | In mice and in young adult humans, the subventricular zone (SVZ) contains multipotent, dividing astrocytes, some of which, when cultured, produce neurospheres that differentiate into neurons and glia. It is unknown whether the SVZ of very old humans has this capacity. Here, we report that neural stem/progenitor cells c... |
2,323,968 | Neonatal nodular fasciitis of the larynx. | We want to describe a case of neonatal laryngeal nodular fasciitis. A 5-day-old female presented with stridor. Fiberoptic transnasal laryngoscopy identified a smooth ball-valving mass obstructing the glottis. Direct microlaryngoscopy demonstrated a lesion originating from the right laryngeal ventricle. Endoscopic thera... |
2,323,969 | Antagonist of peroxisome proliferator-activated receptor gamma induces cerebellar amyloid-beta levels and motor dysfunction in APP/PS1 transgenic mice. | Recent evidences show that peroxisome proliferator-activated receptor gamma (PPARgamma) is involved in the modulation of the amyloid-beta (Abeta) cascade causing Alzheimer's disease (AD) and treatment with PPARgamma agonists protects against AD pathology. However, the function of PPARgamma steady-state activity in Abet... |
2,323,970 | An impedance sensor to monitor and control cerebral ventricular volume. | This paper presents a sensor for monitoring and controlling the volume of the cerebrospinal fluid-filled ventricles of the brain. The measurement principle of the sensor exploits electrical conductivity differences between the cerebrospinal fluid and the brain tissue. The electrical contrast was validated using dog bra... |
2,323,971 | Regulation of maternal food intake and mother-pup interactions by the Y5 receptor. | Neuropeptide Y (NPY) is increased in the hypothalamus during lactation. To investigate the role of the NPY Y5 receptor during lactation, an antisense oligodeoxynucleotide (ODN) targeted to the NPY Y5 receptor, an equivalent scrambled ODN or vehicle, was chronically infused into the 3rd ventricle of lactating rats from ... |
2,323,972 | The significance of measurement of serum unbound bilirubin concentrations in high-risk infants. | In the management of neonatal hyperbilirubinemia, total bilirubin (TB) concentration is not specific enough to predict the brain damage caused by bilirubin toxicity. Unbound bilirubin (UB) easily passes the blood-brain barrier and causes neurotoxicity. We aimed to evaluate whether serum UB concentration would be a usef... |
2,323,973 | Neonatal MRI in preterm infants with periventricular leukomalacia and mild disability. | The aim of the present study was to describe the neonatal magnetic resonance imaging (MRI) findings of preterm infants with periventricular leukomalacia and mild neurological disability.</AbstractText>MRI findings at term equivalent were retrospectively investigated in eight preterm infants with mild disability and per... |
2,323,974 | Cavernous hemangioma of the mesencephalon: tonsillouveal transaqueductal approach. | Recent advances in microsurgical techniques facilitate surgical resection of brainstem lesions that were previously considered inoperable. In this article we present, for the first time, the tonsillouveal transaqueductal approach to access a progressively symptomatic cavernoma within the depth of the tegmentum of the m... |
2,323,975 | SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes. | Heart failure development goes along with a transition from hypertrophic growth to apoptosis induction. In adult cardiomyocytes SMAD proteins are only activated under apoptotic, but not under hypertrophic conditions and are increased at the transition to heart failure. Therefore, SMADs could be candidates that turn the... |
2,323,976 | Neuronal classes in the corticoid complex of the telencephalon of the strawberry finch, Estrilda amandava. | The present study, based on neurohistological techniques (Nissl-staining, Golgi-impregnation), focuses on the cytoarchitecture of the corticoid complex in the strawberry finch, Estrilda amandava. This complex in birds occupies the dorsolateral surface of the telencephalic pallium and remains subdivided into an intermed... |
2,323,977 | The effects of bicuculline and muscimol on glutamate-induced feeding behavior in broiler cockerels. | This study was designed to examine the effects of intracerebroventricular (ICV) injection of bicuculline (GABA(A) receptor antagonist) and muscimol (GABA(A) receptor agonist) on glutamate-induced eating response in 24-h food-deprived (FD24) broiler cockerels. At first, guide cannula was surgically implanted in the righ... |
2,323,978 | Novel micropatterned cardiac cell cultures with realistic ventricular microstructure. | Systematic studies of cardiac structure-function relationships to date have been hindered by the intrinsic complexity and variability of in vivo and ex vivo model systems. Thus, we set out to develop a reproducible cell culture system that can accurately replicate the realistic microstructure of native cardiac tissues.... |
2,323,979 | Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. | Detailed understanding of I(Ks) gating complexity may provide clues regarding the mechanisms of repolarization instability and the resulting arrhythmias. We developed and tested a kinetic model to interpret physiologically relevant I(Ks) properties, including pause-dependence and modulation by beta-adrenergic receptors... |
2,323,980 | Intraventricular meningiomas: radiological findings and clinical features in 12 patients. | To characterize the computed tomography (CT) and magnetic resonance (MR) imaging findings and clinical features of intraventricular (IV) meningiomas.</AbstractText>CT (n=8) and MR (n=12) images and medical records of 12 patients (five men and seven women; mean age, 36 years; range, 14-68 years) with pathologically prov... |
2,323,981 | A contemporary definition and classification of hydrocephalus. | This review focuses on the problems related to defining hydrocephalus and on the development of a consensus on the classification of this common problem. Such a consensus is needed so that diverse research efforts and plans of treatment can be understood in the same context. The literature was searched to determine the... |
2,323,982 | [Factor VII deficiency revealed by intracranial hemorrhage]. | Constitutional factor VII deficiency is a hereditary disease with recessive autosomic transmission. Its incidence is estimated to be 1/1,000,000 in the general population. We report a case of severe factor VII deficiency in infancy revealed by an intracranial hemorrhage in a 2-month-old infant. We describe the clinical... |
2,323,983 | Circumventricular organs: a novel site of neural stem cells in the adult brain. | Neurogenesis in the adult mammalian nervous system is now well established in the subventricular zone of the anterolateral ventricle and subgranular zone of the hippocampus. In these regions, neurons are thought to arise from neural stem cells, identified by their expression of specific intermediate filament proteins (... |
2,323,984 | Surgical outcome of tuberculous meningitis hydrocephalus treated by endoscopic third ventriculostomy: prognostic factors and postoperative neuroimaging for functional assessment of ventriculostomy. | Endoscopic third ventriculostomy (ETV) is increasingly being used as an alternative treatment for post-tuberculous meningitis (TBM) hydrocephalus. The aim of this study was to affirm the role of ETV in patients with TBM hydrocephalus and also to study the usefulness of cine phase-contrast MR imaging (cine MR imaging) f... |
2,323,985 | Correlation between ventriculomegaly on prenatal magnetic resonance imaging and the need for postnatal ventricular shunt placement. | Pediatric neurosurgeons are increasingly called on to provide prognostic data regarding the antenatal diagnosis of ventriculomegaly. This study was designed to determine if there is a correlation between prenatal MR imaging results and the need for ventricular shunt placement during the neonatal period.</AbstractText>T... |
2,323,986 | Intraventricular cerebral cavernomas: a series of 12 patients and review of the literature. | Intraventricular cavernomas (IVCs) occur in only 2-10% of patients with cerebral cavernomas. Reports concerning IVC are scarce and are limited mostly to sporadic case reports. In this paper, the authors present a series of 12 patients with IVCs that were treated at a single neurosurgical department. In addition, the au... |
2,323,987 | Periventricular echodensity measured with the integrated backscatter system: from a qualitative assessment to a quantitative approach. | The degree of periventricular white matter echodensity in preterm infants has been utilized as a sign of the early ultrasonographic appearance of periventricular leukomalacia, and this has been called periventricular echodensity (PVE).</AbstractText>The aim of this study was to quantitatively measure PVE utilizing a ne... |
2,323,988 | Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy. | Conduction slowing of the electric impulse that drives the heartbeat may evoke lethal cardiac arrhythmias. Mutations in SCN5A, which encodes the pore-forming cardiac sodium channel alpha subunit, are associated with familial arrhythmia syndromes based on conduction slowing. However, disease severity among mutation carr... |
2,323,989 | Heritability of left ventricular and papillary muscle heart size: a twin study with cardiac magnetic resonance imaging. | Earlier studies in monozygotic (MZ) and dizygotic (DZ) twins showed genetic variance on echocardiographically determined heart size. However, cardiovascular magnetic resonance (CMR) is more precise and reproducible. We performed a twin study relying on CMR, focusing on left ventricular (LV) mass and papillary muscle, s... |
2,323,990 | Colocalization of connexin 36 and corticotropin-releasing hormone in the mouse brain. | Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, unknown. Prev... |
2,323,991 | [How chicken embryo survives after half of shell is sealed?]. | The goal of this study was to explore the development of the gas transport systems in chick embryos after half of the shell surface is closed on incubation day 11. By the end of day 3 of the experiment (incubation day 14), the vascular reduction in the chorioallantois under the covered zone is fully compensated by the ... |
2,323,992 | MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections. | Matrix-assisted laser desorption/ionization (MALDI)-tandem mass spectrometry (MS)/MS is a proven reliable tool for visualizing the spatial distribution of dosed drugs and their primary metabolites in animal tissue sections.</AbstractText><AbstractText Label="MATERIALS & METHODS" NlmCategory="METHODS">The rat brain ... |
2,323,993 | Long-term implantation of deep brain stimulation electrodes in the pontine micturition centre of the Göttingen minipig. | To implant deep brain stimulation (DBS) electrodes in the porcine pontine micturition centre (PMC) in order to establish a large animal model of PMC-DBS.</AbstractText>Brain stems from four Göttingen minipigs were sectioned coronally into 40-mum-thick histological sections and stained with Nissl, auto-metallograph... |
2,323,994 | Effects of microgravity and hypergravity on platelet functions. | Many serious thrombotic and haemorrhagic diseases or fatalities have been documented in human being exposed to microgravity or hypergravity environments, such as crewmen in space, roller coaster riders, and aircrew subjected to high-G training. Some possible related organs have been examined to explore the mechanisms u... |
2,323,995 | Brainstem cavernous malformations. | Brainstem cavernous malformations (CMs) continue to present a considerable source of controversy in the neurosurgical community, with an accumulating volume of literature detailing their natural history and their surgical and radiosurgical management. As part of a systematic review of the literature, 12 natural history... |
2,323,996 | Identification of small-molecule modulators of mouse SVZ progenitor cell proliferation and differentiation through high-throughput screening. | Adult mouse subventricular zone (SVZ) neural stem/progenitor cells are multipotent self-renewing cells that retain the capacity to generate the major cell types of the central nervous system in vitro and in vivo. The relative ease of expanding SVZ cells in culture as neurospheres makes them an ideal model for carrying ... |
2,323,997 | Virtual ventriculostomy with 'shifted ventricle': neurosurgery resident surgical skill assessment using a high-fidelity haptic/graphic virtual reality simulator. | Based on a study of 48 neurological residents using a high fidelity haptic/graphic virtual reality simulator to perform ventricular cannulation, we recorded absolute Euclidean distance from the catheter tip to the foramen of Monroe within the ventricle. The data suggest that as expected, successful first attempts to ca... |
2,323,998 | Role of unilateral adrenalectomy in bilateral primary aldosteronism: a 22-year single center experience. | The aim of the study was to examine blood pressure and biochemical responses to unilateral adrenalectomy in patients with bilateral primary aldosteronism (PA) and identify predictive parameters.</AbstractText>PA considered due to bilateral autonomous production of aldosterone is usually treated medically. Unilateral ad... |
2,323,999 | Olfactory bulb ventricles as a frequent finding in magnetic resonance imaging studies of the olfactory system. | Background. In some species an embryologic cavity inside the olfactory bulb (OB) persists and is called olfactory bulb ventricle (OBV). It is generally assumed that OBVs in humans are solitary findings representing remnants of embryologic structures that were not fully regressed, although the incidence of OBVs was neve... |
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