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2,324,200 | The metabolic approach in patients with heart failure: effects on left ventricle remodeling. | Metabolic modulation has been an attractive therapeutic approach to heart failure as scientific evidence for an altered metabolic state in the failing heart has been demonstrated for decades. However, the ability to safely alter the substrate metabolism in the myocardium without adverse effects while at the same time b... |
2,324,201 | Totally tubular: the mystery behind function and origin of the brain ventricular system. | A unique feature of the vertebrate brain is the ventricular system, a series of connected cavities which are filled with cerebrospinal fluid (CSF) and surrounded by neuroepithelium. While CSF is critical for both adult brain function and embryonic brain development, neither development nor function of the brain ventric... |
2,324,202 | Ependymal cells along the lateral ventricle express functional P2X(7) receptors. | Ependymal cells line the cerebral ventricles and are located in an ideal position to detect central nervous system injury and inflammation. The signaling mechanisms of ependymal cells, however, are poorly understood. As extracellular adenosine 5'-triphosphate is elevated in the context of cellular damage, experiments w... |
2,324,203 | Inflammatory pseudotumor in the lateral ventricle with repeated bleeding-case report-. | Inflammatory pseudotumor is an uncommon lesion with unknown etiology characterized by sclerosing inflammation which clinically and radiographically mimics a neoplastic lesion. A 47-year-old man presented with sudden headache and dysarthria. Brain CT scan revealed a 2.6x2.2 cm sized, round, and hyperdense mass in the an... |
2,324,204 | Ventricular intramyocardial electrograms and their expected potential for cardiac risk surveillance, telemonitoring, and therapy management. | Ventricular intramyocardial electrograms are recorded with electrodes directly from the heart either in intraventricular or epimyocardial position and may be acquired either from the spontaneously beating or from the paced heart. The morphology of these signals differs significantly from that of body surface ECG record... |
2,324,205 | Change in conduction velocity due to fiber curvature in cultured neonatal rat ventricular myocytes. | Computer modeling of cardiac propagation suggests that curvature of muscle fibers modulates conduction velocity (CV). The effect could be involved in arrhythmogenesis by altering the dynamics of reentrant wavefronts or by causing propagation block. To verify the existence of this effect experimentally, we measured CV i... |
2,324,206 | Upregulation of phosphorylated alphaB-crystallin in the brain of children and young adults with Down syndrome. | Our previous proteomic studies disclosed upregulation of alphaB-crystallin, a small heat shock protein, in the brain tissue of Ts65Dn mice, a mouse model for Down syndrome (DS). To validate data obtained in model animals, we studied at present the levels and distribution of total alphaB-crystallin and its forms phospho... |
2,324,207 | Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI. | In humans, mutations of amyloid precursor protein (APP) and presenilins (PS) 1 and 2 are associated with amyloid deposition, brain structural change and cognitive decline, like in Alzheimer's disease (AD). Mice expressing these proteins have illuminated neurodegenerative disease processes but, unlike in humans, quantit... |
2,324,208 | Imaging the corpus callosum, septum pellucidum and fornix in children: normal anatomy and variations of normality. | The midline structures of the supra-tentorial brain are important landmarks for judging if the brain has formed correctly. In this article, we consider the normal appearances of the corpus callosum, septum pellucidum and fornix as shown on MR imaging in normal and near-normal states. |
2,324,209 | Cardiac rupture due to fall: a case study. | Studies have shown that cardiac ruptures due to blunt trauma are seen more often than expected. However, epicardial injuries and atrial ruptures are common findings in deaths due to falls. Our aim is to present a unique, isolated cardiac rupture in a 2 year-old child resulting from a fall from a bed, to evaluate autops... |
2,324,210 | The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate. | This article reviews the effects of changes of heart rate on the ventricular action potential duration. These can be divided into short term (fractions of a second), resulting from the kinetics of recovery of membrane currents, through to long term (up to days), resulting from changes of protein expression. We concentr... |
2,324,211 | A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord. | Rosette-forming glioneuronal tumors of the fourth ventricle are rare brain tumors, and only 19 such lesions have been previously reported. This report presents the first case of a rosette-forming glioneuronal tumors arising from the spinal cord. A 44-year-old woman presented with a 15-year history of dissociated sensor... |
2,324,212 | Cognitive dysfunction and its clinical and radiological determinants in patients with symptomatic arterial disease and diabetes. | Both vascular disease and diabetes type 2 (DM2) decrease cognitive functioning in elderly people. It is uncertain if DM2 affects cognition independent of vascular disease. In patients with symptomatic arterial disease, we studied the effect of DM2 on cognition and identified clinical and radiological determinants for i... |
2,324,213 | Fibroblast growth factor-9 inhibits astrocyte differentiation of adult mouse neural progenitor cells. | Fibroblast growth factor-9 (FGF9) is expressed in the CNS and is reported to be a mitogen for glial cells, to promote neuronal survival, and to retard oligodendrocyte differentiation. Here we examined the effects of FGF9 on the differentiation, survival, and proliferation of adult neural progenitor cells derived from t... |
2,324,214 | Altered gene expression may underlie prolonged duration of the QT interval and ventricular action potential in streptozotocin-induced diabetic rat heart. | Ventricular electrical conduction has been investigated in the streptozotocin (STZ)-induced diabetic rat. Diabetes was induced with a single injection of STZ (60 mg/kg bodyweight, ip). The ECG was measured continuously, in vivo, using a biotelemetry system. Left ventricular action potentials were recorded with an extra... |
2,324,215 | Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling. | Exogenous activation of central nervous system glucagon-like peptide-1 (GLP-1) receptors (GLP-1Rs) reduces food intake. Experiments addressed whether endogenous central GLP-1R activity is involved in the control of normal feeding and examined which gastrointestinal satiation signals contribute to this control. Given th... |
2,324,216 | Severe hyponatraemia in the setting of hypopituitarism associated with empty sella and herniation of the optic chiasm and gyrus rectus. | We present a patient with progressive weakness over months caused by untreated hyponatraemia. When hyponatraemia became severe, the patient could not move without help, was lethargic and had endocrinological dysfunction. Symptomatic therapy brought no improvement. MRI of the brain showed empty sella with gross herniati... |
2,324,217 | Explanation for the electrocardiogram in subendocardial ischemia of the anterior wall of the left ventricle. | Recently, an important electrocardiogram picture indicating anterior wall ischemia was discussed, characterized by (1) loss of R wave and (2) not infrequently a notch in the negative limb of the QRS complexes in the precordial leads, combined with (3) ST depression and (4) a tall peaked T wave. An explanation of this e... |
2,324,218 | Temporally resolved differential proteomic analysis of human ventricular CSF for monitoring traumatic brain injury biomarker candidates. | A shotgun proteomic approach based on nanoflow liquid chromatography (nanoLC) in conjunction with matrix assisted laser desorption/ionization time of flight tandem mass spectrometry (MALDI TOF MS/MS) was utilized to quantitatively analyze the protein content of consecutive ventricular cerebrospinal fluid (CSF) samples ... |
2,324,219 | Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor. | Dysembryoplastic neuroepithelial tumor (DNT)- like lesions arise in extracortical locations and behave in a benign fashion similar to that of cortical DNTs. They usually come to attention by symptoms and signs of increased intracranial pressure rather than focal neurological impairment. Here we report a case of 9-year-... |
2,324,220 | Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat. | Ketone bodies are considered to act as a signal to suppress gonadotropin release during negative energy balance. The present study examined the effect of 48-h fasting on the mRNA expressions of monocarboxylate transporter 1 (MCT1) and MCT2, which are involved in ketone body transport, in several brain regions. Quantita... |
2,324,221 | Melatonin transmits photoperiodic signals through the MT1 melatonin receptor. | Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefor... |
2,324,222 | Repair of infarcted myocardium using mesenchymal stem cell seeded small intestinal submucosa in rabbits. | Myocardial infarction (MI) remains a common and deadly disease. Using tissue-engineered cardiac grafts to repair infarcted myocrdium is considered to be a therapeutic approach. This study tested the feasibility of using MSCs-seeded SIS to repair chronic myocardial infarction in a rabbit model. MI in rabbits was created... |
2,324,223 | [Nemaline myopathy detected with respiratory failure and right ventricular heart failure]. | We describe the case of a 40-year-old woman who was admitted for dyspnea and pitting edema of the lower extremities. Severe type II respiratory failure and right ventricular heart failure were present. Non-invasive positive pressure ventilation (NIPPV) improved the symptoms and blood gas values. Since the results of re... |
2,324,224 | Activated spinal cord ependymal stem cells rescue neurological function. | Spinal cord injury (SCI) is a major cause of paralysis. Currently, there are no effective therapies to reverse this disabling condition. The presence of ependymal stem/progenitor cells (epSPCs) in the adult spinal cord suggests that endogenous stem cell-associated mechanisms might be exploited to repair spinal cord les... |
2,324,225 | Maternal separation induced alterations of neurogenesis in the rat rostral migratory stream. | 1. The aim of our study was to investigate the possibility that maternal separation, an experimental model for studies of early environmental influences, has an effect on postnatal neurogenesis in neurogenic pathway--the rostral migratory stream (RMS). 2. Rat pups were subjected to maternal separation daily for 3 h, st... |
2,324,226 | Vestibular syndrome due to a choroid plexus papilloma in a ferret. | A 6-year-old, castrated male ferret (Mustela putorius furo) was presented with progressive neurological signs consisting of a right-sided head tilt and ataxia. Neurological examination revealed hemiparesis and absence of proprioception on the right side, consistent with central vestibular syndrome. Measurement of blood... |
2,324,227 | Experimental neuronal migration disorders following the administration of ibotenate in hamsters: the role of the subventricular zone in the development of cortical dysplasia. | To examine the role of subventricular zone in cortical dysplasia, an experimental model was established using a neuronal tracing study. Ibotenate is a glutamate receptor agonist, and its intracerebral injection produces excitotoxic lesions mimicking microgyria and heterotopia. A total of 72 newborn hamsters were subjec... |
2,324,228 | Tailored cricoplasty: an improved modification for reconstruction in subglottic tracheal stenosis. | Subglottic laryngotracheal stenosis with side-to-side narrowing poses a challenge for successful reconstruction. The standard technique of anterior cricoid resection was modified to address a small ventricle with lateral narrowing.</AbstractText>This study was a retrospective chart review and telephone questionnaire fo... |
2,324,229 | [Echocardiographic evaluation in patients with idiopathic ventricular arrhythmias originating from right ventricular outflow tract before and one year after radiofrequency catheter ablation].<Pagination><StartPage>38</StartPage><EndPage>42</EndPage><MedlinePgn>38-42</MedlinePgn></Pagination><Abstract><AbstractText Labe... | In the spontaneous hypertensive rats (SHR)--line NISAG--most cardiac hystiocytes of the left ventriculum have signs of ultrastructure damage to a variable extent. First of all the contractile and energetic function of cardiac hystiocytes has different abnormalities. Administration of Lipril (20 mg/kg daily, during thre... |
2,324,230 | Fetal borderline cerebral ventriculomegaly: clinical significance and management. | The aim of this study was to evaluate the clinical significance and the management of fetal borderline lateral cerebral ventriculomegaly.</AbstractText>Fetuses with a sonographic diagnosis of lateral cerebral ventriculomegaly isolated or associated to other fetal malformations were followed monthly and a review of the ... |
2,324,231 | Physiological differences between transplanted and host tissue cause functional decoupling after in vitro transplantation of human embryonic stem cell-derived cardiomyocytes. | Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) might provide cells to repopulate injured myocardium. Electrical coupling of these cells to the host myocardium is a prerequisite for improved functionality. The aim of this study was to investigate electrical interaction of hESC-CMs with myocardial tissue and... |
2,324,232 | Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age. | Our goals were to compare cognitive, language, behavioral, and educational outcomes of preterm children to term controls and to evaluate the impact of neonatal brain injury, indomethacin, and environmental risk factors on intellectual function at 12 years of age.</AbstractText>A total of 375 children born in 1989-1992 ... |
2,324,233 | Altered heart rhythm dynamics in very low birth weight infants with impending intraventricular hemorrhage. | Intraventricular hemorrhage remains an important problem among very low birth weight infants and may result in long-term neurodevelopmental disabilities. Neonatologists have been unable to accurately predict impending intraventricular hemorrhage. Because alterations in the autonomic nervous system's control of heart rh... |
2,324,234 | [The process of remodeling of left chambers of the heart and dysfunction of endothelium of peripheral vessels in hypertensive premenopausal women]. | Results of ultrasound study of 230 premenopausal women with I-II stage essential hypertension (EH) in relation to functional state of endothelium of peripheral arteries are presented. Endothelial dysfunction in hypertensive premenopausal women can be one of factors contributing to remodeling of left cardiac chamber. Wo... |
2,324,235 | Characterization of systolic intervals in healthy, conscious sheep. | To characterize systolic intervals of the left ventricle and their relationship with heart rate in conscious sheep. Animals-11 healthy Romanov sheep (age range, 3 months to 10 years).</AbstractText>Systolic intervals and indices of myocardial contractility of the left ventricle were measured in conscious sheep by use o... |
2,324,236 | A fatal heroin addict with myocardial lesion.<Pagination><StartPage>279</StartPage><EndPage>283</EndPage><MedlinePgn>279-83</MedlinePgn></Pagination><Abstract><AbstractText>This is a histological report of a myocardial lesion of a 44-year-old white man who was found dead in a hotel with circumstances strongly suggestiv... | This is a histological report of a myocardial lesion of a 44-year-old white man who was found dead in a hotel with circumstances strongly suggestive of heroin intoxication. Based on. autopsy findings and toxicologic analysis, the present case was an instance of straight forward heroin overdose in snorter. The most stri... |
2,324,237 | [Left ventricular remodeling in outpatients with chronic renal failure treated with hemodialysis].<Pagination><StartPage>21</StartPage><EndPage>24</EndPage><MedlinePgn>21-4</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To study left ventricular remodeling (LVR) in patients with en... | Fifty four operations of one and a half ventricular correction were made for the treatment of congenital heart failure (CHF) in 1999-2006. Age of the patients varied from 1 yr 3 mo to 29 yr. Indications to the use of this method are discussed along with analysis of its role in the surgical treatment of CHF. Two-directi... |
2,324,238 | Subependymomas: a clinicopathological study of 6 symptomatic cases. | Subependymomas are rare, slow-growing, ependymal neoplasms that commonly occur in the fourth or lateral ventricles.</AbstractText>A retrospective study of 6 histologically proven subependymomas was undertaken to analyse their clinicopathological characteristics.</AbstractText>There were five male and one female patient... |
2,324,239 | Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics. | The excitation-contraction coupling properties of cardiac myocytes isolated from different regions of the mammalian left ventricular wall have been shown to vary considerably, with uncertain effects on ventricular function. We embedded a cell-level excitation-contraction coupling model with region-dependent parameters ... |
2,324,240 | Deleting the accessory subunit KChIP2 results in loss of I(to,f) and increased I(K,slow) that maintains normal action potential configuration. | Four voltage-gated potassium currents, I(to,f) (K(V)4.2), I(to,s) (K(V)1.4), I(K,slow) (K(V)1.5+K(V)2.1), and I(SS) (TASK1), govern murine ventricular repolarization. Although the accessory subunit KChIP2 influences I(to,f) expression, in preliminary experiments we found that action potential duration (APD) is maintain... |
2,324,241 | Expression of orexin A and its receptor 1 in the choroid plexuses from buffalo brain. | The hypothalamic peptide orexin A, deriving from the proteolytic cleavage of the precursor molecule prepro-orexin, has a wide range of physiological effects including the regulation of feeding behaviour, neuroendocrine functions, sleep-wake cycle, and energy homeostasis. Lowered excretion of orexin A into the cerebrosp... |
2,324,242 | Distribution patterns of the Na+-Ca2+ exchanger and caveolin-3 in developing rabbit cardiomyocytes. | In adult cardiac cells the established mechanism of excitation-contraction coupling is by calcium-induced calcium release (CICR) mediated by L-type Ca(2+) channels. However, in neonate cardiomyocytes, a CICR modality involving reverse mode Na(+)-Ca(2+) exchanger (NCX) activity predominates. This has been hypothesized t... |
2,324,243 | Large congenital melanotic nevi in an extremity with neurocutaneous melanocytosis. | A 14-day-old boy presented with a large congenital melanocytic nevus over his left thigh with approximately 17 satellite nevi distributed over the rest of his skin surface. Six weeks later, he developed generalized tonic-clonic seizures and additional satellite nevi became apparent (n > 20). A subsequent brain magne... |
2,324,244 | Comparison of cerebrospinal fluid obtained by ventricular endoscopy and by lumbar puncture in patients with hydrocephalus secondary to neurocysticercosis. | Compare the differences between proteins, glucose, and morphological cellular counts from ventricular cerebrospinal fluid obtained by neuroendoscopy and lumbar puncture.</AbstractText>This was a retrospective, transversal study. From January 2003 until June 2006, 30 neuroendoscopies were performed on patients with hydr... |
2,324,245 | Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. | In this study a Ca(2+) sensitive protein was targeted to the mitochondria of adult rabbit ventricular cardiomyocytes using an adenovirus transfection technique. The probe (Mitycam) was a Ca(2+)-sensitive inverse pericam fused to subunit VIII of human cytochrome c oxidase. Mitycam expression pattern and Ca(2+) sensitivi... |
2,324,246 | The partial 5-HT1A receptor agonist buspirone enhances neurogenesis in the opossum (Monodelphis domestica). | We demonstrate for the first time that neurogenesis in the adult Monodelphis opossum has a typical mammalian pattern and occurs only in the dentate gyrus (DG) and subventricular zone (SVZ) of the lateral ventricles. In these two brain regions neurogenesis is present throughout the lifespan, although its rate is reduced... |
2,324,247 | Primary CNS lymphoma. | Primary CNS Lymphoma (PCNSL) accounts for 3% of all primary brain tumors with a median age at onset of about 62 years. In the vast majority of cases, PCNSL presents as unifocal or multifocal enhancing lesions on MRI, frequently adjacent to the ventricles. Stereotactic biopsy is the diagnostic procedure of choice reveal... |
2,324,248 | In vivo forced expression of myocardin in ventricular myocardium transiently impairs systolic performance in early neonatal pig heart. | The aim of this study was to determine the effects of forced expression of myocd-A in the left ventricular (LV) myocardium on cardiac performance in early neonatal piglets. LV transfection with the gene for homeodomain only protein (hop), an antagonist of myocd-mediated activities, was also performed. Gene delivery was... |
2,324,249 | Management of cranial deformity following ventricular shunting. | Ventricular shunt-induced craniosynostosis is a widely recognised cause of secondary craniosynostosis. We reviewed the management and long-term outcome of the cases of cranial deformity post cerebrospinal fluid shunting in our unit and compared these with previously published series.</AbstractText>The Australian Cranio... |
2,324,250 | Development of a high-throughput assay for monitoring cAMP levels in cardiac ventricular myocytes. | G-protein-coupled receptors (GPCRs) represent the largest family of transmembrane receptors involved in cell signal transduction. Many of these GPCRs convey their pharmacological actions by regulating intracellular levels of 3',5'-cyclic adenosine monophosphate (cAMP). Although the heart expresses more than 100 GPCRs, ... |
2,324,251 | [Modified reconstruction of the cistern magna for treatment of syringomyelia with Chiari malformation: clinical analysis of 35 cases]. | To explore the surgical approaches, microsurgical techniques and therapeutic effect of modified cistern magna reconstruction for treating of syringomyelia with Chiari malformations.</AbstractText>The clinical data of 35 patients with syringomyelia complicated by Chiari malformations were retrospectively reviewed, and t... |
2,324,252 | A new approach for observing cerebral cisterns and ventricles via a percutaneous lumbosacral route by using fine, flexible fiberscopes. | To establish a new method for the diagnosis of central nervous system diseases, the authors visualized the cerebral cisterns and ventricles via a percutaneous lumbosacral route by using newly developed fine, flexible fiberscopes.</AbstractText>Fine, flexible fiberscopes, 0.9 and 1.4 mm in diameter, were introduced up t... |
2,324,253 | Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses. | Hepatic damage occurs in males and ovariectomized (OVX), not in proestrus (PE), females following trauma-hemorrhage (T-H). The mechanism responsible for hepatoprotection remains unknown. We hypothesized protection in PE is a result of enhanced heme oxygenase-1 (HO-1)-derived down-regulation of liver inflammatory respon... |
2,324,254 | Fetal cerebral ventricular pointing as a marker of spina bifida: incidence and observational agreement. | Occipital cerebral ventricular pointing is a promising intracranial marker for spina bifida. We sought to determine (1) the incidence of pointing in fetuses with and without spina bifida and (2) inter-observer and intraobserver agreement for visualizing pointing.</AbstractText>Second-trimester transverse axial images o... |
2,324,255 | Pulsed magnetohydrodynamic blood flow in a rigid vessel under physiological pressure gradient. | Blood flow in a steady magnetic field has been of great interest over recent years. Many researchers have examined the effects of magnetic fields on velocity profiles and arterial pressure, and major studies have focused on steady or sinusoidal flows. In this paper, we present a solution for pulsed magnetohydrodynamic ... |
2,324,256 | Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. | Cardiomyocytes contain subsarcolemmal (SSM) and interfibrillar (IFM) mitochondria, which differ in their respiratory and calcium retention capacity. Connexin 43 (Cx43) is located at the inner membrane of SSM, and Cx43 is involved in the cardioprotection by ischemic preconditioning (IP). The function of Cx43-formed chan... |
2,324,257 | A case with noncompaction of the left ventricular myocardium detected by 64-slice multidetector computed tomography. | Noncompaction is a rare, primary genetic cardiomyopathy affecting the left ventricle. The diagnosis is usually established by echocardiography, and less frequently by left ventriculography. Cardiac magnetic resonance and electrocardiography-gated multidetector computed tomography are evolving noninvasive modalities to ... |
2,324,258 | Morphometric study of the ventricular segment of the human fetal heart between 13 and 20 weeks' gestation. | Our objective was to determine the normal dimensions of the ventricular segment of the human fetal heart between 13 and 20 weeks' gestation.</AbstractText>103 hearts obtained by necropsy were dissected and measurements of different portions of ventricles were determined under stereoscopic magnification. In each ventric... |
2,324,259 | Effect of nadcin on energy supply system and apoptosis in ischemia-reperfusion injury to the myocardium. | Nadcin in a dose of 90 mg/kg administered to dogs with subacute stage of ischemia-reperfusion myocardial injury immediately after blood flow resumption normalized redox potential of cardiomyocytes and mitochondria and restored the total content of adenyl and pyridine nucleotides. The decrease in the synthesis of ATP an... |
2,324,260 | Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation. | The choroid plexus, being part of the blood-brain barriers and responsible for the production of cerebrospinal fluid, is ideally positioned to transmit signals into and out of the brain. This study, using microarray analysis, shows that the mouse choroid plexus displays an acute-phase response after an inflammatory sti... |
2,324,261 | Endoscopic stomy of the septum pellucidum: indications, technique, and results. | Although endoscopic perforation of the septum pellucidum in obstruction of the foramen of Monro is well known, detailed reports on endoscopic septostomy, including surgical technique and results are lacking in the literature.</AbstractText>All intracranial endoscopic procedures performed between February 1993 and March... |
2,324,262 | Echocardiographic tissue deformation imaging of right ventricular systolic function in endurance athletes. | To investigate the physiological adaptation of the right ventricle (RV) in response to endurance training and to define reference values for regional deformation in the RV in endurance athletes.</AbstractText>Healthy controls (n = 61), athletes (n = 58), and elite athletes (n = 63) were prospectively enrolled with a tr... |
2,324,263 | [Pediatric neurocysticercosis]. | Cysticercosis: parasitic disease which affects 3% of the population in Mexico. It is considered that there are more than 50 million infected people in the world, endemic in Mexico, Central and South America, Africa, Asia and India. It is considered the most important neurological infectious disease world-wide for its c... |
2,324,264 | [Subependymal nodules-sudependymal giant cell astrocytoma complex in children with tuberous sclerosis]. | The object of this paper is to describe the imaging and clinical characteristics of subependymal nodule (SN) - subependymal giant cell astrocytoma (SGCA) complex in tuberous sclerosis and analyze its evolution in order to attempt early detection and the prevention of intracranial hypertension. We evaluated 22 patients ... |
2,324,265 | The IVH score: a novel tool for estimating intraventricular hemorrhage volume: clinical and research implications. | Intraventricular extension of intracerebral hemorrhage (IVH) is an independent predictor of poor outcome. IVH volume may be important in outcome prediction and management; however, it is difficult to measure routinely.</AbstractText>We reviewed the charts and computed tomographies of a cohort of consecutive patients wi... |
2,324,266 | Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls. | We aimed to improve on the single-atlas ventricular segmentation method of (Carmichael, O.T., Thompson, P.M., Dutton, R.A., Lu, A., Lee, S.E., Lee, J.Y., Kuller, L.H., Lopez, O.L., Aizenstein, H.J., Meltzer, C.C., Liu, Y., Toga, A.W., Becker, J.T., 2006. Mapping ventricular changes related to dementia and mild cognitiv... |
2,324,267 | Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. | The time- and voltage-dependent inward current generated by the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contributes to the tissue-specific rhythmic activities in the brain and heart. Four isoforms (HCN1-HCN4) have been identified. Previous studies showed that different HCN isoforms may form f... |
2,324,268 | Prevalence of subependymal giant cell tumors in patients with tuberous sclerosis and a review of the literature. | To investigate the prevalence of subependymal giant cell ependymomas (SEGA) in patients with tuberous sclerosis complex (TSC).</AbstractText>We performed a retrospective cross-sectional study in a cohort of 285 patients with known TSC. Institutional review board approval was obtained. We included all 214 TSC-patients w... |
2,324,269 | Interferon-induced Mx proteins in brain tissue of multiple sclerosis patients. | Recombinant interferon-beta is proven as an effective long-term treatment in patients with multiple sclerosis (MS). Unlike in other chronic inflammatory diseases, endogenous synthesis of type I interferons (IFN-alpha and IFN-beta) has not been studied extensively in MS. Mx proteins A and B (MxA and MxB) are intracellul... |
2,324,270 | Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats. | To address the pathophysiological relevance of ovarian hormones in chronic beta-adrenergic stimulation-induced myocardial injury, we assessed impairments of Ca(2+)-mediated cell signaling in the left ventricle of ovariectomized female rats.</AbstractText><AbstractText Label="RESEARCH DESIGN/METHODS" NlmCategory="METHOD... |
2,324,271 | Abnormalities of the foetal cerebral cortex. | Prenatal ultrasound has concentrated on readily visible cerebral structures including head size, shape, ventricles, CSP (cavum septi pellucidi), cerebellar size/vermian presence and cisterna magna. However, apart from these easily visible structures it is important to evaluate the brain itself. Patients who initially a... |
2,324,272 | Diminishing the impact of the partial volume effect in cardiac SPECT perfusion imaging. | The partial volume effect (PVE) significantly restricts the absolute quantification of regional myocardial uptake and thereby limits the accuracy of absolute measurement of blood flow and coronary flow reserve by SPECT. The template-projection-reconstruction method has been previously developed for PVE compensation. Th... |
2,324,273 | Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. | Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to ... |
2,324,274 | Wortmannin inhibits the increase in myofilament Ca(2+) sensitivity induced by cross-talk of endothelin-1 with norepinephrine in canine ventricular myocardium. | Endothelin-1 (ET-1) modulates cardiac contractility by cross-talk with norepinephrine (NE) in canine ventricular myocardium. The present experiments were performed to investigate the influence of wortmannin that has inhibitory action on phosphatidylinositol 3-kinase (PI3-K) (IC50 = 3 nM) and myosin light chain kinase (... |
2,324,275 | Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. | The sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P) pathway, known to determine the fate and growth of various cell types, can enhance cardiac myocyte survival in vitro and provide cardioprotection in acute ex vivo heart preparations. However, the relevance of these findings to chronic cardiac pathology has nev... |
2,324,276 | [Unusual locations of tuberculosis: three case reports]. | We report three cases of tuberculosis of unusual location in Malagasy patients. The first patient presented with intracardiac tuberculoma during pulmonary tuberculosis. The second patient who had no significant musculoskeletal past medical history presented with tuberculous polymyositis. The remaining one presented wit... |
2,324,277 | Rapid component I(Kr) of cardiac delayed rectifier potassium currents in guinea-pig is inhibited by alpha(1)-adrenoreceptor activation via protein kinase A and protein kinase C-dependent pathways. | Ventricular tachyarrhythmias are often precipitated by physical or emotional stress, indicating a link between increased adrenergic stimulation and cardiac ion channel activity. Human ether-a-go-go related gene (hERG) potassium channels conduct the rapid component of delayed rectifier potassium current, I(kr), a crucia... |
2,324,278 | Ischemia induced neural stem cell proliferation and differentiation in neonatal rat involved vascular endothelial growth factor and transforming growth factor-beta pathways. | Brain ischemia is a leading cause of mortality and morbidity in premature infants. Knowing the fate of neural stem cells in the subventricular zone (SVZ) after ischemia and the mechanisms that determine this fate would be useful in manipulating neural stem cell proliferation and differentiation and possibly in reversin... |
2,324,279 | A priority treatment of the intraventricular hemorrhage (IVH) should be performed in the patients suffering intracerebral hemorrhage with large IVH. | In patients suffering from intracerebral hemorrhage (ICH) with ventricular hemorrhage (IVH), the IVH severity is thought to be associated with prognosis. Therefore, treating IVH may be a beneficial therapeutic target. In this study, by examining the associations among IVH severity, hydrocephalus, initial level of consc... |
2,324,280 | Endomyocardial fibrosis as a cause of Budd-Chiari syndrome and fatal pulmonary embolism.<Pagination><StartPage>191</StartPage><EndPage>192</EndPage><MedlinePgn>191-2</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.carpath.2008.12.012</ELocationID><Abstract><AbstractText>A 24-year-old-man had r... | A 24-year-old-man had right-sided heart failure of 3 months' duration. A Doppler echocardiogram revealed atrium and right ventricular enlargement, obliteration of the right ventricular apex, and a mass with an echolucent center measuring 20x21 mm in the right ventricular outlet. He died of pulmonary embolism. At autops... |
2,324,281 | Colloid cyst of third ventricle mimicking normal tension glaucoma. | Colloid cysts are rare intracranial tumors most commonly found in the third ventricle. We present a case of colloid cyst of the third ventricle that manifested as bilateral advance optic disc cupping, superior hemifield defects in the visual fields and normal intraocular pressure. |
2,324,282 | Cold stress effects on cardiomyocytes nuclear size in rats: light microscopic evaluation. | Total body induced hypothermia and myocardial cooling are effective methods regarding myocardial protection during heart surgery and ischemia. It is described in previous studies that extreme low temperature exposure causes mitochondrial cristae and myofilament disarrangement in cardiomyocytes, however, no investigatio... |
2,324,283 | Human cardiac fibroblasts express B-type natriuretic peptide: fluvastatin ameliorates its up-regulation by interleukin-1alpha, tumour necrosis factor-alpha and transforming growth factor-beta. | B-type natriuretic peptide (BNP) is a cardiac hormone, which plays a major role in body fluid and cardiovascular homeostasis. Produced by cardiac ventricles, its expression is highly regulated by various mediators. Canine cardiac fibroblasts have been identified as a source of BNP. Cardiac fibroblasts are key regulator... |
2,324,284 | [Myocardial infarction, left ventricle remodeling and cellular therapy]. | The paper brings an overview of results of the most important and significant clinical studies dealing with the issues of bone marrow stem cell implantation in patients with acute myocardial infarction. On the world scale, research has been focused on this area for several years. Much hope is put primarily on the possi... |
2,324,285 | Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study. | The enzyme cytochrome P450 aromatase is responsible for conversion of androgens to estrogens. Estrogens have been implicated in neurophysiology and neuropathology. The present study investigated the presence of aromatase immunoreactivity in the temporal, parietal and occipital cortices, olfactory bulb, cerebellum, and ... |
2,324,286 | Normal pressure hydrocephalus or neuroborreliosis? | An 80-year-old woman presented with progressive cognitive decline and with a 6-month history of gait ataxia. Brain MRI depicted enlarged ventricles and periventricular lesions. Clinical improvement after CSF spinal tap test suggested a normal pressure hydrocephalus syndrome. But CSF pleocytosis with activated lymphocyt... |
2,324,287 | Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice. | Carnosine (beta-alanyl-l-histidine), an endogenous dipeptide substrate of the proton-coupled oligopeptide transporter PEPT2, plays an important role in many physiological processes. This study examined the effect of PEPT2 on the disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice. After e... |
2,324,288 | Down-regulation of SM22/transgelin gene expression during H9c2 cells differentiation. | The embryonic rat ventricle H9c2 cells maintain a proliferative state (P condition) in the presence of 10% FCS. However, by reducing serum concentration and in the presence of retinol acetate, proliferation is stopped, myogenic transdifferentiation is inhibited while cardiac differentiation is preserved (D condition). ... |
2,324,289 | Intraventricular haemorrhage caused by the rupture of a dural arteriovenous malformation of the middle cranial fossa. | Dural arteriovenous malformations of the middle cranial fossa are very rare. Venous drainage flows either through superficial leptomeningeal veins or through the sphenoparietal, sphenopetrous and/or sphenobasilar sinuses. They often have an aggressive course and therefore poor outcome. It is essential to analyse and un... |
2,324,290 | Internal capsule size associated with outcome in first-episode schizophrenia. | Subtle structural brain abnormalities are an established finding in first-episode psychosis. Nevertheless their relationship to the clinical course of schizophrenia is controversially discussed. In a multicentre study 45 first-episode schizophrenia patients (FE-SZ) underwent standardized MRI scanning and were followed ... |
2,324,291 | Effect of chronic intermittent hypobaric hypoxia on α(1)-adrenergic receptor of myocardium participates in the cardioprotection. | The purpose of the present study was to investigate the effect of chronic intermittent hypobaric hypoxia (CIHH) on α(1)-adrenergic receptors and the role of alpha(1)-adrenergic receptors in the protection of CIHH against ischemic injury of myocardium. Sixty-six adult male Sprague-Dawley rats were randomly divided... |
2,324,292 | Combined diffuse light reflectance and electrical impedance measurements as a navigation aid in deep brain surgery. | The aim of this study is to assess reflected light intensity combined with impedance as a navigation aid during stereotactic neurosurgery.</AbstractText>During creation of 21 trajectories for stereotactic implantation of deep brain stimulation electrodes in the globus pallidus internus or subthalamus (zona incerta or s... |
2,324,293 | A novel type of self-beating cardiomyocytes in adult mouse ventricles. | This study was designed to investigate the presence of resident heart cells that are distinct from terminally-differentiated cardiomyocytes. Adult mouse heart was coronary perfused with collagenase, and ventricles were excised and further digested. After spinning cardiomyocyte-containing fractions down, the supernatant... |
2,324,294 | [Relationship between the grading of periventricular echodensities and periventricular white matter cystic lesions in preterm infants]. | To understand the relationship of the grading of periventricular echodensities (PVE) with the morbidity and the occurrence time of periventricular white matter cystic lesions in preterm infants.</AbstractText>A retrospective, single-centre cohort study of 120 preterm infants with PVE diagnosed by ultrasonography betwee... |
2,324,295 | Endoscopic third ventriculostomy: 5 years' experience at the All India Institute of Medical Sciences. | Endoscopic third ventriculostomy (ETV) is one of the efficacious surgical options available for obstructive hydrocephalus, and is preferable to a ventriculoperitoneal shunt in those eligible. We retrospectively studied 115 cases, who underwent ETV at our institute over the last 5 years. Thirty-eight patients were infan... |
2,324,296 | Upregulated TWIK-related acid-sensitive K+ channel-2 in neurons and perivascular astrocytes in the hippocampus of experimental temporal lobe epilepsy. | To identify the modulation of Tandem of P-domains in a weak inwardly rectifying K(+) channel (TWIK)-related acid-sensitive K(+) (TASK)-2 channel expressions in epilepsy, we conducted a comparative analysis of TASK-2 channel immunoreactivity in the hippocampus of a pilocarpine-induced rat epilepsy model.</AbstractText>W... |
2,324,297 | From neurotransmitters to neurotrophic factors to neurogenesis. | New neurons continue to be produced in adult mammals, including humans, predominantly in the anterior subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus. This update focuses on the emerging concept that adult CNS neurogenesis can be regulated by targeting neurotransmitter recepto... |
2,324,298 | Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1beta. | The objective of the present study was to investigate the role of brain kappa-opioid receptors (KOR) in the antidipsogenic effect promoted by third ventricle injections of interleukin-1beta (IL-1beta). Wistar male rats were submitted to three different, thirst-inducing, physiological conditions: dehydration induced by ... |
2,324,299 | Novel bench-top perfusion system improves functional performance of bioengineered heart muscle. | Research in the area of cardiac tissue engineering is focused on the development of functional 3-dimensional cardiac muscle tissue in vitro, which includes bioengineered cardiac patches, pumps and ventricles. One of the major challenges in the field of cardiovascular tissue engineering is determining how to support the... |
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