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2,324,300 | Altered iron metabolism is part of the choroid plexus response to peripheral inflammation. | Iron is essential for normal cellular homeostasis but in excess promotes free radical formation and is detrimental. Therefore, iron metabolism is tightly regulated. Here, we show that mechanisms regulating systemic iron metabolism may also control iron release into the brain at the blood-choroid plexus-cerebrospinal fl... |
2,324,301 | Congenital homonymous hemianopia and cortical migration abnormalities in a young adult. | Congenital homonymous hemianopia isan uncommon entity usually diagnosed in early adulthood, with the patient having no prior knowledge of a visual field defect. The authors describe an 18-year-old woman with asymptomatic congenital homonymous hemianopia and an unusual constellation of associated intracranial abnormalit... |
2,324,302 | Transventricular neuroendoscopic excision of giant racemose subarachnoid cysticercosis. | Subarachnoid cysticercosis, an uncommon form of neurocysticercosis, can occasionally grow to giant size causing mass effect and obstructive hydrocephalus. These often require surgical excision to relieve the mass effect and re-establish the cerebrospinal fluid (CSF) pathways.</AbstractText>The authors report a rare cas... |
2,324,303 | Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. | Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive infantile neoplasm of uncertain origin. This study was performed to assess the clinicopathologic and immunohistochemical features of four AT/RT cases.</AbstractText>Two cases were male and two were female, and their ages ranged from 8 to 103 months. Tumors w... |
2,324,304 | Metastatic malignant melanoma manifesting as an intracardiac mass. | Antemortem diagnoses of intracardiac metastases are uncommon. Metastatic melanoma shows a propensity for cardiac involvement, but cardiac involvement by melanoma is rarely identified clinically due to a paucity of cardiac symptoms.</AbstractText>The surgical pathology files of Mayo Clinic were searched for cases of met... |
2,324,305 | The chilling details: hypoxic-ischemic encephalopathy. | Hypoxic-ischemic encephalopathy (HIE) is one of the most important complications found in the newborn period. It is the result of a deprivation of oxygen and glucose to the neural tissue, which may be the result of either hypoxemia or ischemia. Experimental animal research and clinical observations in humans have noted... |
2,324,306 | Reversible foetal cerebral ventriculomegaly and cardiomyopathy under chemotherapy for maternal AML. | Leukaemia in pregnancy is a rare complication demanding a multidisciplinary approach and careful management to handle potential complications and cope with ethical dilemmas.</AbstractText>We report on a patient with acute myeloid leukaemia (AML) relapse in 22 weeks of gestation who received chemotherapy with cytarabine... |
2,324,307 | An intracardiac ectopic thyroid adenoma. | Intracardiac ectopic thyroid tissue is a rare lesion. We present a case of successful excision of an ectopic thyroid adenoma originated from the right ventricular aspect of the interventricular septum and extending to the right ventricular outflow tract. The 12-month follow-up shows normal thyroid function and good cli... |
2,324,308 | [Rare brain tumour in 6-month-old girl]. | A six-month old girl presented with repetitive episodes of vomiting. Soon after admission to hospital she had convulsions. Computertomography showed a tumour in the third ventricle. She was non-radically operated. Histology showed an atypical teratoid/rhabdoid tumour (AT/RT). No active treatment was initiated, and the ... |
2,324,309 | Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge. | Ovulation is central to mammalian fertility, yet the precise mechanism through which oestrogen triggers the gonadotrophin-releasing hormone (GnRH) surge that generates the pre-ovulatory luteinising hormone (LH) surge has remained elusive. The recent discovery that kisspeptin-GPR54 signalling is an essential regulator o... |
2,324,310 | Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the bovine spongiform encephalopathy (BSE) agent. | Decreased rates of transmission of transmissible spongiform encephalopathies (TSEs) to sheep have been attributed to some polymorphisms of the prion protein (PrP) and to a 'species barrier' on interspecies experiments. In addition, the blood-brain barrier may be a further impediment to TSE neuroinvasion. The intracereb... |
2,324,311 | The relation between Glasgow Coma Scale score and later cerebral atrophy in paediatric traumatic brain injury. | To examine initial Glasgow Coma Scale (GCS) score and its relationship with later cerebral atrophy in children with traumatic brain injury (TBI) using Quantitative Magnetic Resonance Imaging (QMRI) at 4 months post-injury. It was hypothesized that a lower GCS score would predict later generalized atrophy. As a guide in... |
2,324,312 | Intraventricular neurocysticercosis. | Neurocysticercosis is the commonest CNS parasitic disease worldwide but cysticercal meningitis and intraventricular lesions are relatively rare, especially in Indian patients. We herein report a girl with cysticercal meningitis that remained undiagnosed and the patient later presented with unilateral hydrocephalous due... |
2,324,313 | Dyke-Davidoff-Masson syndrome in postcerebral malaria. | Dyke-Davidoff-Masson syndrome is a disorder involving hemiatrophy or hypoplasia of 1 cerebral hemisphere secondary to an insult in the developing brain. Often this will manifest with seizures, hemiparesis, mental retardation, and facial changes. Associated with this pathology are the radiologically evident changes, suc... |
2,324,314 | Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension. | Obesity is one of the major risk factors for cardiovascular disease and is often associated with increased oxidative stress and sympathoexcitation. We have already suggested that increased oxidative stress in the brain modulates the sympathetic regulation of arterial pressure in salt-sensitive hypertension, which is of... |
2,324,315 | Ventricular wall granulations and draining of cerebrospinal fluid in chronic giant hydrocephalus. | In rare cases, adults with normal or almost normal cognition may have giant brain ventricles surrounded by a sliver of brain. Because the usual flow of cerebrospinal fluid (CSF) is interrupted in these individuals, they may develop alternative CSF pathways to preserve brain function.</AbstractText>To describe novel mor... |
2,324,316 | Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study. | Global age related white matter changes (ARWMC) are associated with progressive gait disturbances and falls, hypothesised to result from interruptions of cortico-subcortical circuits controlling balance, posture and locomotion.</AbstractText>The location of ARWMC in a large cohort of elderly non-disabled individuals wi... |
2,324,317 | Heart failure management: the present and the future. | Clinical heart failure has been defined for a long time as a clinical syndrome with symptoms and signs including shortness of breath, cyanosis, ascites, and edema. However, in recent years, with the thought of promoting early diagnosis and heart-failure prevention, the concept of heart failure has often been defined si... |
2,324,318 | Short term prognostic role of NT-proBNP in patients after myocardial infarction.<Pagination><StartPage>13</StartPage><EndPage>21</EndPage><MedlinePgn>13-21</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">The clinical and prognostic role of cardiac natriuretic peptides (CNP) in patie... | Physical working capacity (PWC) and maximum oxygen consumption (VO2max) depend on athlete's sports activity. Average amount of PWC for qualified athletes in cyclic kinds of sports activity is 1586+/-339.8 kgm/min (21.8+/-0.638 kgm/min kg), endurance-trained athlete's PWC is 1625+/-359 kgm/min (23.1+/-4.1 kgm/min kg) an... |
2,324,319 | Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice. | Deterioration of cardiac contractility during congestive heart failure (CHF) is believed to involve decreased function of individual cardiomyocytes and may include reductions in contraction magnitude and/or kinetics. We examined the progression of in vivo and in vitro alterations in contractile function in CHF mice and... |
2,324,320 | Post-transplant lymphoproliferative disease presenting as a mass in the left ventricle in a heart transplant recipient at long-term follow-up. | Neoplasms are among the most common solid-organ transplant complications, occurring in 11.7% of all transplant recipients and in 6% to 15% of heart transplant recipients, according to early studies. The skin and lips are the most common sites for neoplasms, but they also appear in the setting of post-transplant lymphop... |
2,324,321 | A case of holocarboxylase synthetase deficiency with insufficient response to prenatal biotin therapy. | Holocarboxylase synthetase (HCS) deficiency is an inborn error of biotin metabolism, leading to a multiple carboxylases deficiency. As the affected fetus sometimes presents with enlargement of the cerebral ventricles and intrauterine growth retardation (IUGR), prenatal administration of biotin has been attempted in som... |
2,324,322 | Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study. | Cortical and subcortical atrophy occurs in multiple sclerosis (MS) and relates to clinical outcomes. FreeSurfer, a voxel-based automated software for brain reconstruction was used to investigate the extent of subcortical and cortical atrophy in 71 MS and 17 clinically isolated syndrome (CIS) patients, and 38 normal con... |
2,324,323 | Failure mechanisms of ventricular tissue due to deep penetration. | Lead perforation is a rare but serious complication of pacemaker implantations, and in the present study the associated tissue failure was investigated by means of in-vitro penetration of porcine and bovine ventricular tissue. Rectangular patches from the right ventricular free wall and the interventricular septum were... |
2,324,324 | Experimental regimen targeting the ependyma slows disease progression in four patients with amyotrophic lateral sclerosis. | In this paper the author proposes that at least some forms of sporadic ALS (amyotrophic lateral sclerosis) arise due to the effects of neurotoxic compounds synthesized by defective ependymal cells in the brain. These cells produce cerebrospinal fluid (CSF) that is laden with neurotoxic compounds that bring about motor ... |
2,324,325 | Combined endoscopic and microsurgical removal of a giant cystic craniopharyngioma in a six-year-old boy. | Giant cystic craniopharyngiomas are rare lesions whose clinical and surgical management is extremely challenging, often requiring more than one craniotomy before obtaining a satisfying removal. We report one case of a giant cystic craniopharyngioma completely excised with a two-step combined use of a minimally invasive... |
2,324,326 | Cellular transfer of macromolecules across the developing choroid plexus of Monodelphis domestica. | Choroid plexus epithelial cells secrete cerebrospinal fluid (CSF) and transfer molecules from blood into CSF. Tight junctions between choroidal epithelial cells are functionally effective from early in development: the route of transfer is suggested to be transcellular. Routes of transfer for endogenous and exogenous p... |
2,324,327 | Integration and sensory experience-dependent survival of newly-generated neurons in the accessory olfactory bulb of female mice. | Newborn neurons generated by proliferative progenitors in the adult subventricular zone (SVZ) integrate into the olfactory bulb circuitry of mammals. Survival of these newly-formed cells is regulated by the olfactory input. The presence of new neurons in the accessory olfactory bulb (AOB) has already been demonstrated ... |
2,324,328 | Adult neurogenesis and the diseased brain. | For a long time it was believed that the adult mammalian brain was completely unable to regenerate after insults. However, recent advances in the field of stem cell biology, including the identification of adult neural stem cells (NSCs) and evidence regarding a continuous production of neurons throughout life in the de... |
2,324,329 | The Valsalva maneuver and Alzheimer's disease: is there a link? | Recent research findings provide evidence for Alzheimer's disease-related changes in brain diseases, such as normal pressure hydrocephalus and traumatic brain injury, and in glaucoma at the level of the retinal ganglion cells. This is a group of diseases that affect central nervous system tissue and are characterized b... |
2,324,330 | Preservation of visual fields with the inferior temporal gyrus approach to the atrium. | Various transcortical approaches have been described for the resection of tumors that lie in the atrium of the lateral ventricle. An approach through the middle temporal gyrus has a short trajectory to the atrium and can grant early access to the tumor's blood supply, but it typically results in damage to the optic rad... |
2,324,331 | Spontaneous third ventriculostomy: definition by endoscopy and cerebrospinal fluid dynamics. | Chronic obstructive hydrocephalus is known to cause ventricular diverticula and, rarely, spontaneous ventriculostomy. The authors present the case of a patient in whom a spontaneous third ventriculostomy was identified with long-standing hydrocephalus secondary to aqueductal stenosis. To their knowledge, this is the fi... |
2,324,332 | Limitations of the transcallosal transchoroidal approach to the third ventricle. | The aim of this study was to determine the anatomical limitations of the transcallosal transchoroidal approach to the third ventricle.</AbstractText>Twenty-six formalin-fixed specimens were studied. Sagittal dissections were used to determine the anatomical relationships of the foramen of Monro, the angle of approach t... |
2,324,333 | [Effects of gamma-aminobutyric acid on the Hering-Breuer inspiratory-inhibitory reflex].<Pagination><StartPage>1356</StartPage><EndPage>1364</EndPage><MedlinePgn>1356-64</MedlinePgn></Pagination><Abstract><AbstractText>In acute experiments on rats, effects of cerebro-ventricular microinjections of the gamma-aminobutyri... | In acute experiments on rats, effects of cerebro-ventricular microinjections of the gamma-aminobutyric acid (GABA) in the ventilation and Hering-Breuer inspiratory-inhibitory reflex were studied. Alteration of this reflex was estimated by changing in amplitude and duration of the esophageal pressure inspiratory oscilla... |
2,324,334 | Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. | We investigate acute effects of axial stretch, applied by carbon fibers (CFs), on diastolic Ca2+ spark rate in rat isolated cardiomyocytes. CFs were attached either to both cell ends (to maximize the stretched region), or to the center and one end of the cell (to compare responses in stretched and nonstretched half-cel... |
2,324,335 | Chronic intracerebroventricular infusion of nociceptin/orphanin FQ produces body weight gain by affecting both feeding and energy metabolism in mice. | Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for opioid receptor-like 1 (ORL1), is involved in various central functions, such as pain, psychological stress, locomotor activity, learning and memory, and feeding regulation. Of these functions, the role of N/OFQ in the regulation of feeding has been suggested by ... |
2,324,336 | Shunt surgery effects on cerebrospinal fluid flow across the aqueduct of Sylvius in patients with communicating hydrocephalus. | We aimed to visualize and quantify the flow of cerebrospinal fluid (CSF) across the aqueduct of Sylvius in patients with communicating hydrocephalus using phase contrast MRI, and to evaluate the effect of ventriculoperitoneal (VP) shunt surgery on flow. We investigated aqueductal CSF flow using cine cardiac-gated phase... |
2,324,337 | Cavernous angiomas of the lateral ventricles. | Cavernous angiomas are vascular malformations which rarely involve the cavities of the lateral ventricles. Knowledge of the specific clinical and neuroradiological features displayed by these lesions is limited by the scarcity of patients included in the reported series.</AbstractText>The aim of this study was to compi... |
2,324,338 | A radiation oncologist's guide to contouring the hippocampus. | Limiting the dose to the hippocampus will likely decrease cognitive problems from brain radiotherapy. The purpose of this article is to present a step-by-step guide to contouring the hippocampus on axial images as would be done in the standard process of planning conformal radiotherapy for brain radiotherapy.</Abstract... |
2,324,339 | Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. | Huntington's disease (HD) is an autosomal dominant, neurodegenerative condition caused by a CAG trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract in the protein huntingtin. Genetic and transgenic studies suggest that the mutation causes disease predominantly via gain-of-funct... |
2,324,340 | Random walk behavior of migrating cortical interneurons in the marginal zone: time-lapse analysis in flat-mount cortex. | Migrating neurons are thought to travel from their origin near the ventricle to distant territories along stereotypical pathways by detecting environmental cues in the extracellular milieu. Here, we report a novel mode of neuronal migration that challenges this view. We performed long-term, time-lapse imaging of medial... |
2,324,341 | Evaluation of delayed neuronal and axonal damage secondary to moderate and severe traumatic brain injury using quantitative MR imaging techniques. | Traumatic brain injury (TBI) is a classic model of monophasic neuronal and axonal injury, in which tissue damage mainly occurs at the moment of trauma. There is some evidence of delayed progression of the neuronal and axonal loss. Our purpose was to test the hypothesis that quantitative MR imaging techniques can estima... |
2,324,342 | Incidence and treatment of left ventricular apical thrombosis in Tako-tsubo cardiomyopathy. | Among 95 patients with Tako-tsubo cardiomyopathy, left ventricular (LV) apical thrombus was documented in 5 (5.3%) patients. The thrombus was mural in 2 (40%), and protruding in 3 (60%) patients. In 4 patients, LV apical thrombus disappeared after anticoagulant therapy. In one patient with protruding thrombus, brain in... |
2,324,343 | Octreotide therapy in two children with intractable postoperative chylothorax. | Postoperative chylothorax is sometimes difficult to be managed either by conventional therapies or by surgery. Herein, we report the experience of octreotide therapy for intractable postoperative chylothorax in two children (one was severe tetralogy of Fallot received Blalock-Taussing shunt, and the other was a single ... |
2,324,344 | [Brain tuberculoma in the child in Antananarivo]. | Brain tuberculoma is a rare localization of extra-pulmonary tuberculoma and considered as the most severe. A 14-year-old girl, without past medical history presented intracranial hypertension, with cerebellar syndrome and visual disorder The laboratory findings were normal. Serological test for HIV was negative. Cerebr... |
2,324,345 | Expression profile and distribution of Efhc1 gene transcript during rodent brain development. | One of the putative causative genes for juvenile myoclonic epilepsy (JME) is EFHC1. We report here the expression profile and distribution of Efhc1 messenger RNA (mRNA) during mouse and rat brain development. Real-time polymerase chain reaction revealed that there is no difference in the expression of Efhc1 mRNA betwee... |
2,324,346 | Lentiviral transfection of ependymal primary cultures facilitates the characterisation of kinocilia-specific promoters. | Ependymal primary cultures (EPCs) are an established model for studying ependymal cell biochemistry and the biology of kinocilia-bearing cells. However, the difficulty in causing them to express transgenes at high efficiency has been an important drawback of the system. Indeed plasmid-based transfection attempts remain... |
2,324,347 | Microsurgical anatomy of the foramen of Luschka in the cerebellopontine angle, and its vascular supply. | Cerebellopontine angle and vascular supply of adjacent brainstem and cerebellum are susceptible to compression and eventual damage by tumors. Delicate and complicated neurosurgical operations in the cerebellopontine angles of the brainstem, where lateral recesses of fourth ventricle empty, are abundant especially opera... |
2,324,348 | Intraoperative direct third ventriculostomy and aqueductal stenting in deep-seated midline brain tumor surgery. | Surgical resection of deep-seated midline brain tumors does not always resolve obstruction of cerebrospinal fluid pathways, and an additional operation--ventricular shunting--is required. To prevent postoperative obstructive hydrocephalus, we combine tumor removal and internal ventricular shunting in 1 stage.</Abstract... |
2,324,349 | Simultaneous suprasellar and pineal germ cell tumors in five late stage adolescents: endocrinological studies and prolonged follow-up. | Primary germ cell tumors (PGCT) of the central nervous system usually develop in the third ventricle area, and most frequently in the pineal region. The suprasellar region is the second preferential site for development of these tumors which are rarely simultaneously present in these two sites. We report five new cases... |
2,324,350 | Sema4C expression in neural stem/progenitor cells and in adult neurogenesis induced by cerebral ischemia. | Sema4C is a transmembrane protein that belongs to axon guidance molecules of semaphorin family. Previous reports have shown that Sema4C could interact with postsynaptic protein PSD95, etc, but the expression and the role of Sema4C in neurogenesis remains unknown. In this study, whole-mount in situ hybridization result ... |
2,324,351 | Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. | Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown.</AbstractText>To investigate the contribution of genetic and environmental factors on brain volume ... |
2,324,352 | Mobilization of neural stem cells and generation of new neurons in 6-OHDA-lesioned rats by intracerebroventricular infusion of liver growth factor. | Neural stem cells with self-renewal and multilineage potential persist in the subventricular zone of the adult mammalian forebrain. These cells remain relatively quiescent but, under certain conditions, can be stimulated, giving rise to new neurons. Liver growth factor (LGF) is a mitogen for liver cells that shows biol... |
2,324,353 | Asymmetrical lateral ventricular enlargement in Parkinson's disease. | A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson's disease (PD). The current study explored these associations further.</AbstractText>Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at ba... |
2,324,354 | Model of excitation-contraction coupling of rat neonatal ventricular myocytes. | The neonatal rat ventricular myocyte culture is one of the most popular experimental cardiac cell models. To our knowledge, the excitation-contraction coupling (ECC) of these cells, i.e., the process linking the electrical activity to the cytosolic Ca2+ transient and contraction, has not been previously analyzed, nor h... |
2,324,355 | Chronic ethanol consumption resulting in the downregulation of insulin receptor-beta subunit, insulin receptor substrate-1, and glucose transporter 4 expression in rat cardiac muscles. | The objective of this study was to investigate the effect of chronic ethanol intake on the expression of insulin receptor beta subunit (IR-beta), insulin receptor substrate-1 (IRS-1), and glucose transporter 4 (Glut4) in rat cardiac muscle. Forty-eight male Wistar rats were randomly classified into four groups and to e... |
2,324,356 | The significance of fetal ventriculomegaly: etiology, short- and long-term outcomes. | Fetal cerebral ventriculomegaly (VM) is diagnosed when the width of one or both ventricles, measured at the level of the glomus of the choroid plexus (atrium), is > or = 10 mm. VM can result from different processes: abnormal turnover of the cerebrospinal fluid (CSF), neuronal migration disorders, and destructive pr... |
2,324,357 | Acute ventriculoperitoneal shunt malfunction following opening of the spinal subarachnoid space: a case series. | Malfunction of cerebrospinal shunts is common and due to multiple etiologies. We hypothesize that opening of the spinal dura may prompt shunt failure in select individuals with previously unrecognized tenuous shunt function.</AbstractText>The authors describe five patients with shunted hydrocephalus who underwent proce... |
2,324,358 | Preliminary reference values for electrocardiography, echocardiography and myocardial morphometry in the European brown hare (Lepus europaeus). | The study aimed at defining reference values for electrocardiographic (ECG) and echocardiographic parameters as well as macroscopic dimensions of the heart and microscopic dimensions of cardiomyocytes in the European brown hare. The studies were conducted on 30 adult, clinically healthy hares of either sex caught in Po... |
2,324,359 | Possible common central pathway for resistin and insulin in regulating food intake. | Adipose tissue has been the object of intense research in the field of obesity and diabetes diseases in the last decade. Examination of adipocyte-secreted peptides led to the identification of a unique polypeptide, resistin (RSTN), which has been suggested as a link between obesity and diabetes. RSTN plays a clearly do... |
2,324,360 | Multiple congenital anomalies/mental retardation syndrome with multiple circumferential skin creases: a new syndrome? | We describe a combination of multiple congenital anomalies, a severe psychomotor retardation and seizures in a 9-year-old Tunisian boy with circumferential ringed skin creases. He had symmetrical circumferential skin creases on arms, legs, and penis. Craniofacial anomalies included: an elongated face, tight forehead, h... |
2,324,361 | Massive, fatal, intracardiac thrombosis associated with prothrombin complex concentrate. | Prothrombin complex concentrates are frequently used to rapidly reverse anticoagulation with vitamin K antagonists associated with life-threatening bleeding. We report a patient receiving warfarin who presented to the emergency department with an international normalization ratio greater than 12.8 in cardiac tamponade ... |
2,324,362 | [Effect of gap junction on the cardioprotection of ischemic postconditioning in rat heart]. | To determine whether the cardioprotection of ischemic postconditioning and heptanol in ischemic heart against ischemia/reperfusion (I/R) is mediated by gap junction.</AbstractText>The effect of ischemic postconditioning, heptanol at different doses (0.03, 0.06, 0.30, and 0.60 mg/kg) and AAP10 (10 mg/kg) on the intact r... |
2,324,363 | [The effects of Sphing-1-phosphate(S1P) on the potassium channel of the ventricular myocytes]. | To study the effect of Sphingosine-1-phosphate on the delayed rectifier potassium current (IK) and the inward rectifier potassium current (IK1) of guinea pig isolated ventricular myocytes.</AbstractText>Whole cell patch clamp technique was applied to record the delayed rectifier potassium current and the delayed rectif... |
2,324,364 | [Effect of safflower injection on pulmonary hypertension in rat during chronic hypoxia and hypercapnia]. | To study the effect of Safflower injection (a compound of Chinese Traditional medicine) on pulmonary hypertension in rat during chronic hypoxia and hypercapnia.</AbstractText>Sprague-Dawley rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + Safflower injection... |
2,324,365 | [Effect of hypoxia on the expressions of intermedin/ adrenomedullin2 in plasma and the tissues of heart and lung in rats]. | To study the effect and significances of two-week hypoxia on the expression of intermedin/adrenomedullin2 (IMD/ADM2) in plasma and the tissues of heart and lung in rats.</AbstractText>Twenty male SD rats were randomly divided into normal control group and hypoxia group. The concentrations of IMD/ADM2 and adrenomedullin... |
2,324,366 | c-Kit+ bone marrow stem cells differentiate into functional cardiac myocytes. | The utility of bone marrow cells (BMCs) to regenerate cardiac myocytes is controversial. The present study examined the capacity of different types of BMCs to generate functional cardiac myocytes. Isolated c-kit(+) BMCs (BMSCs), c-kit(+) and crude BMCs from the adult feline femur were membrane stained with PKH26 dye or... |
2,324,367 | Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma. | A 6-year-old spayed female domestic ferret was evaluated because of lethargy, alopecia, pruritus, and an abdominal mass.</AbstractText>On initial examination, nonregenerative anemia, mild azotemia, and a large left adrenal gland mass were identified. However, deterioration of the ferret's general condition prevented ex... |
2,324,368 | Permeability of the blood-brain barrier to a rhenacarborane. | The treatment of brain malignancies with boron neutron capture therapy depends on their ability to cross the blood-brain barrier (BBB). An especially promising class of boron-containing compounds is the rhenacarboranes that, if able to cross the BBB, could act as delivery vehicles as well as a source of boron. Here, we... |
2,324,369 | Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence. | Pyroglutamyl peptidase II (PPII), a highly specific membrane-bound metallopeptidase that inactivates TRH in the extracellular space, is tightly regulated by thyroid hormone in cells of the anterior pituitary. Whether PPII has any role in the region where axons containing hypophysiotropic TRH terminate, the median emine... |
2,324,370 | Effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats using microarray technology. | We have used microarray technology to detect the effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats.</AbstractText>Male Sprague-Dawley rats (180-200 g) were randomly divided into three groups: sham-operated; coronary artery ligation; and coronary artery liga... |
2,324,371 | [Body lateropulsion as the main symptom of pontine vascular disease--comparison with lateral medullary vascular disease]. | Lateropulsion of the body is rarely encountered as an isolated or predominant manifestation of pontine cerebrovascular disease. We compared 2 cases of pontine vascular lesions with 3 cases of lateral medullary infarction; all the patients had presented with body lateropulsion. The patients with pontine lesions tended t... |
2,324,372 | Prenatal diagnosis of fetal cardiac right ventricular diverticulum disappearing at three months of age. A case report and literature review. | Congenital cardiac diverticula are transmural localized protrusions within the free wall of the ventricles. Right ventricular diverticula are rarely diagnosed during the fetal period, and due to their rarity, their natural history remains unclear. We present a case of prenatal diagnosis of right ventricular diverticulu... |
2,324,373 | Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway. | The satiating potency of CCK has been well characterized, including its mediation by capsaicin-sensitive vagal primary afferents. We have previously shown that peripherally administered CCK activates the MAPK-signaling cascade in a population of nucleus of the solitary tract (NTS) neurons and that preventing ERK1/2 pho... |
2,324,374 | Short-term versus long-term intermittent hypobaric hypoxia on cardiac fibrosis and Fas death receptor dependent apoptotic pathway in rat hearts. | It is unknown if short-term and long-term intermittent hypobaric hypoxic challenges both exert pro-apoptotic effects on Fas death receptor-dependent apoptotic pathway in rat hearts. Seventy-two Sprague-Dawley rats were randomly assigned into two groups. First, short-term intermittent hypobaric hypoxia (STIHH)-normobari... |
2,324,375 | Large left ventricular metastasis causing left ventricular outflow tract obstruction and haemolysis. | Although post-mortem studies would suggest that cardiac metastases occur frequently, many of these metastases remain clinically silent. However, symptomatic lesions may also remain unrecognized due to overshadowing by other symptoms of the primary malignancy. Patients undergoing treatment for cancer are not routinely s... |
2,324,376 | Invasive giant prolactinoma with loss of therapeutic response to cabergoline: expression of angiogenic markers. | The present study reports the case of a 70-year-old Caucasian man who was referred to the Military Hospital of Buenos Aires for evaluation of a giant sellar-extrasellar mass with extension in the right temporal lobe and compression of the third ventricle. Patient was initially responsive to cabergoline with reduction o... |
2,324,377 | Phase-contrast cine MRI versus MR cisternography on the evaluation of the communication between intraventricular arachnoid cysts and neighbouring cerebrospinal fluid spaces. | The objective of this study was to evaluate the role of phase-contrast cine magnetic resonance imaging (PC-MRI) in detecting possible communications between intraventricular arachnoid cysts (IV-ACs) and cerebrospinal fluid (CSF) spaces based on MR cisternography (MRC) comparison.</AbstractText>Twenty-one patients with ... |
2,324,378 | Brain and ventricles in very low birth weight infants at term: a comparison among head circumference, ultrasound, and magnetic resonance imaging. | The aim of this study was to assess the relationship among the size of the lateral ventricles, head-circumference measure, and brain volumes. In addition, the association between ventricular dilatation and various brain lesions was defined.</AbstractText>A total of 257 preterm very low birth weight (< or =1500 g) in... |
2,324,379 | Modeling interaction for segmentation of neighboring structures. | This paper presents a new method for segmenting medical images by modeling interaction between neighboring structures. Compared to previously reported methods, the proposed approach enables simultaneous segmentation of multiple neighboring structures for improved robustness. During the segmentation process, the object ... |
2,324,380 | Experience on Transfontanelle Neurosonography in Kano, Nigeria: a preliminary report. | To retrospectively audit and analyse all the Transfontanelle Neurosonographic scans performed at the Aminu Kano Teaching Hospital (AKTH), between January to September, 2004.</AbstractText>Information on the gray scale appearance of the ventricles, cerebral and cerebellar parenchyma, extra axial fluid spaces, status of ... |
2,324,381 | Schizencephaly in infants with thrombophilia. | Schizencephaly is an uncommon congenital malformation of neuronal migration characterized by a gray matter-lined cleft extending from the pial surface to the ependymal surface of the lateral ventricles. Its etiology is heterogeneous and consists of hereditary factors or destructive processes that occur during the secon... |
2,324,382 | Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: a 5-year longitudinal study. | We assessed the relationship between gray matter (GM) and white matter (WM) atrophy and clinical status in early relapsing-remitting multiple sclerosis (MS) patients over 5 years. A group of 181 patients who participated in the ASA (Avonex-Steroid-Azathioprine) study and had complete clinical and MRI assessments over 2... |
2,324,383 | Morphometric abnormalities and hyperanxiety in genetically epileptic rats: a model of psychiatric comorbidity? | Imaging studies of epilepsy patients with comorbid affective disturbance demonstrate morphometric changes in limbic brain regions implicated in psychiatric disease. Genetic Absence Epilepsy Rats from Strasbourg (GAERS), specifically bred for their epilepsy phenotype, also exhibit elevated anxiety-like behaviors suggest... |
2,324,384 | Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's disease. | Brain asymmetry is linked with several neurological diseases, and transthyretin (TTR) is a protein sequestering beta-amyloid (Abeta) and helping to prevent the Alzheimer's disease (AD). We show, by real time reverse transcription-polymerase chain reaction (RT-PCR), in situ hybridization and Western blotting, that TTR e... |
2,324,385 | Simulation of the QRS complex using papillary muscle positions as the site of early activation in human subjects. | Simulation of the electrical activation of the heart and its comparison with real in vivo activation is a promising method in testing potential determinants of excitation. Simulation of the electrical activity of the human heart is now emerging as a step forward for understanding and predicting electrophysiologic patte... |
2,324,386 | Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. | The present work is aimed at identifying and characterizing, at a molecular and functional level, new ionic conductances potentially involved in the excitation-secretion coupling and proliferation of cardiac ventricular fibroblasts. Among potassium channel transcripts which were screened by high-throughput real-time PC... |
2,324,387 | Effects of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventricular injection of amyloid beta protein into mice. | The effects of yokukansan, a traditional Japanese medicine, on aggressiveness and motor activities were examined in mice after injection of amyloid beta protein (Abeta) into the lateral ventricle of the brain. The results were compared with those of conventional (haloperidol) and atypical (risperidone) antipsychotic me... |
2,324,388 | Effects of abstinence on brain morphology in alcoholism: a MRI study. | Chronic alcohol abuse leads to morphological changes of the brain. We investigated if these volumetric changes are reversible after a period of abstinence. For this reason 41 male and 15 female alcohol patients underwent MRI-scanning after in-patient detoxification (baseline) entering alcoholism treatment programs, and... |
2,324,389 | Multiple fractures involving the orbit and incidental finding of large fourth ventricular epidermoid. | Epidermoid tumors located in the fourth ventricle are exceedingly rare, and the patients usually present with headaches, vertigo, and/or disequilibrium. We discuss the management of orbital floor and lateral wall fracture in a patient who was also incidentally diagnosed to have a large fourth ventricular epidermoid cys... |
2,324,390 | Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. | Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning and memory, and neuroplasticity. Further, exogenous treatment with BDNF or exposing animals to enrichment and exercise regimens, which also increase BDNF, enhances behavioral recovery after brain injury. Thus, the b... |
2,324,391 | The frequency and extent of mammillary body atrophy associated with surgical removal of a colloid cyst. | Patients who have had a colloid cyst removed from the third ventricle sometimes experience some difficulty with day-to-day memory. This study provided quantitative MR imaging volume measures of 1 structure potentially responsible for mnemonic problems, the mammillary bodies. Additional volume estimates in structures co... |
2,324,392 | Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. | Ischemia/reperfusion (I/R) injury is characterized by the induction of oxidative stress and proinflammatory cytokine expression. Recently demonstrating that oxidative stress and TNF-alpha each stimulate interleukin (IL)-18 expression in cardiomyocytes, we hypothesized that I/R also induces IL-18 expression and thus exa... |
2,324,393 | Reduced conduction reserve of the propagating cardiac impulse in the diabetic rat heart: a model study. | Conduction velocity is dependent on two main factors: intercellular electrical coupling and cellular electrical excitability. There is significant redundancy, 'conduction reserve', in these parameters such that significant reduction in the conduction velocity of the action potential requires either a severe change in o... |
2,324,394 | Noninvasive estimation of three-dimensional cardiac electrical activities from body surface potential maps. | A noninvasive three-dimensional (3D) cardiac electrical imaging (3DCEI) approach, which can estimate the location of the initiation site (IS) of activation and the resultant 3D activation sequence (AS) from body surface potential maps (BSPMs), was validated in an intact large mammalian model (swine) during acute ventri... |
2,324,395 | Non-rigid registration based segmentation of brain subcortical structures using a priori knowledge. | Segmentation of the brain internal structures is an important and a challenging task due to their complex shapes, partial volume effects, low contrasts and anatomical variability between subjects. In this paper we propose a new non-rigid registration method that automatically segments the deep brain internal structures... |
2,324,396 | Computer-aided diagnosis scheme for classification of lacunar infarcts and enlarged Virchow-Robin spaces in brain MR images. | The detection of asymptomatic lacunar infarcts on magnetic resonance (MR) images is important because their presence indicates an increased risk of severe cerebral infarction. However, accurate identification of lacunar infarcts on MR images is often hard for radiologists because of the difficulty in distinguishing lac... |
2,324,397 | Neonatal probabilistic models for brain, CSF and skull using T1-MRI data: preliminary results. | Inappropriate results may be produced if one uses adult or pediatric atlases for evaluation of neonatal cerebral images for morphological studies. This is mainly due to anatomical particularities typical for this early stage of development. In this paper, we describe the construction of a digital neonatal brain atlas f... |
2,324,398 | Automatic compartmental decomposition for 3D MR images of human brain. | A new method is developed to automatically decompose human brain MR images into cerebrum, cerebellum and brainstem. It utilizes the partial differential equations based shape bottlenecks algorithm to segment an interior brain tissue region into three compartmental seeds. Then the compartmental decomposition is obtained... |
2,324,399 | Aortic impedance in Little mice. | The Little dwarf mouse lives 30% longer than its age-matched wild-type (WT) mouse. We determined aortic input impedance in 21 (8 Little, 13 WT) 4 month-old mice. Modulus of impedance was calculated from the Fourier transformed aortic pressure (P) and average luminal flow velocity (V(avg)) as |Z(i)| = |P|/|V(avg)|. Char... |
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