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2,324,400 | On the calculation of principle curvatures of the left-ventricular surfaces. | A local description of the shape of the left ventricle is relevant in assessing the process of adverse ventricular remodeling, associated with most cardiac pathologies, and in monitoring reverse remodeling by therapy. To quantify local shape of the left ventricle, one can calculate the curvature of its epicardial or en... |
2,324,401 | Large scale cardiac modeling on the Blue Gene supercomputer. | Multi-scale, multi-physical heart models have not yet been able to include a high degree of accuracy and resolution with respect to model detail and spatial resolution due to computational limitations of current systems. We propose a framework to compute large scale cardiac models. Decomposition of anatomical data in s... |
2,324,402 | Magnetic resonance imaging of migrating neuronal precursors in normal and hypoxic-ischemic neonatal rat brains by intraventricular MPIO labeling. | In this study, 10-day-old normal rats (n=6) and hypoxic-ischemic (H-I) neonatal rats (n=6) were injected with the micronsized iron oxide particles (MPIOs) into the anterior lateral ventricle. 2D and 3D high-spatial resolution MRI were performed with a 7T animal scanner 1 day before the MPIOs injection and hour 3, day 3... |
2,324,403 | Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats. | It has been suggested that the opioid-like neuropeptide nociceptin/orphanin FQ(N/OFQ) and its receptor (NOPr) may contribute to Parkinson's disease. Based on this idea, the aim of our study was to investigate the involvement of the N/OFQ-NOPr system in an animal model of Parkinson's disease and to evaluate if this neur... |
2,324,404 | Sexual dimorphic stages affect both proliferation and serotonergic innervation in the adult rostral migratory stream. | One of the sexual dimorphic differences in adult rodents is neural proliferation. Here we demonstrate that physiological hormone stages can modulate this proliferation in the adult forebrain. Female mice, both pregnant and synchronized in oestrus, exhibited higher proliferating cell percentages than males in both the r... |
2,324,405 | Cerebral extension of steroid-responsive meningitis arteritis in a boxer. | A comatose 30-month-old, entire male boxer was presented because of an acute history of a cluster of three to four seizures. Neurological examination suggested a diffuse to multifocal intracranial lesion. Magnetic resonance tomography revealed symmetrical multifocal to diffuse changes of the cerebral grey matter and ep... |
2,324,406 | Morgagni on apoplexy in De Sedibus: a historical perspective. | This paper considers the historical significance of case reports on apoplexy and paralysis in Morgagni's De Sedibus et Causis Morborum. When autopsies became relatively common in the sixteenth century, Galen's speculation that apoplexy was caused by the accumulation of cold phlegm or black bile in the cerebral ventricl... |
2,324,407 | The cellular composition and morphological organization of the rostral migratory stream in the adult human brain. | The rostral migratory stream (RMS) is the major pathway by which progenitor cells migrate from the subventricular zone (SVZ) to the olfactory bulb (OB) in rodents, rabbits and primates. However, the existence of an RMS within the adult human brain has been elusive. Immunohistochemical studies utilising cell-type specif... |
2,324,408 | Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. | The autophagic lysosomal system contributes to the removal of cytosolic components, and abnormality of lysosomal proteases has been reported in the brain of patients with Alzheimer's disease (AD). However, the role of lysosome in tau degradation is still elusive. Here, we infused chloroquine, 3-methyladenine or rapamyc... |
2,324,409 | Late cardiotoxic effects of anthracycline chemotherapy in childhood malignancies. | To determine the frequency of changes in left ventricular function in patients, at least 5 years after completion of anthracycline-therapy for childhood malignancy.</AbstractText>Echocardiographic examination was performed on 58 patients (36 males and 22 females) with mean age of 17.5+/-4.6 years (range 9-29 years, med... |
2,324,410 | Left ventricular long-axis function in myasthenia gravis. | Myasthenia gravis (MG) primarily affects skeletal muscles, but influence on cardiac function has been suggested. The aim of this study was to assess left ventricular long-axis function in MG patients compared to healthy controls, and to examine whether any MG-related heart involvement was influenced by the acetylcholin... |
2,324,411 | Lack of specificity of antibodies directed against human beta-adrenergic receptors. | The present study was designed to investigate if antibodies against beta-adrenergic receptors (betaARs) can be used to determine expression of betaAR in human myocardium. Western blotting was performed to investigate the specificity of antibodies directed against beta(1)AR and beta(2)AR in human left ventricular tissue... |
2,324,412 | Intracranial subdural hematoma after spinal anesthesia in a parturient. | : An intracranial subdural hematoma is a rare and potentially fatal complication of spinal anesthesia.</AbstractText>: A gravida 2, para 1 underwent a repeat cesarean for transverse fetal lie. Four hours postoperatively she developed a severe headache with acute nausea and vomiting. Computed tomography scan revealed a ... |
2,324,413 | Sulfadiazine partially protects the rat temporal cortex from amyloid beta peptide (25-35)-induced alterations of the somatostatinergic system. | The aim of this study was to elucidate whether sulfadiazine, shown to improve cognitive capacity in the elderly, can prevent amyloid beta peptide (Abeta) (25-35)-induced impairment of the somatostatinergic system previously reported by our group in rat temporal cortex. Male Wistar rats were thus treated with sulfadiazi... |
2,324,414 | Intramyocardial injection of tannic acid attenuates postinfarction remodeling: a novel approach to stabilize the breaking extracellular matrix. | Myocardial infarction is associated with early matrix metalloproteinase activation and extracellular matrix degradation. We tested the hypothesis that stabilizing the original extracellular matrix of the infarcted left ventricle with local injection of tannic acid would preserve cardiac structure and function.</Abstrac... |
2,324,415 | Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. | Various approaches to myocardial reconstruction have been developed for the treatment of congestive heart failure resulting from ischemic cardiomyopathy.</AbstractText>In this study we determined whether in situ application of polymers could reshape left ventricular geometry in a chronic rodent model of ischemic cardio... |
2,324,416 | Why the embryo still matters: CSF and the neuroepithelium as interdependent regulators of embryonic brain growth, morphogenesis and histiogenesis. | The key focus of this review is that both the neuroepithelium and embryonic cerebrospinal fluid (CSF) work in an integrated way to promote embryonic brain growth, morphogenesis and histiogenesis. The CSF generates pressure and also contains many biologically powerful trophic factors; both play key roles in early brain ... |
2,324,417 | Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel. | Kv1.5 channels conduct the ultra-rapid delayed rectifier potassium current (I(Kur)), and in humans, Kv1.5 channels are highly expressed in cardiac atria but are scarce in ventricles. Pharmacological blockade of human Kv1.5 (hKv1.5) has been regarded as effective for prevention and treatment of re-entry-based atrial tac... |
2,324,418 | Accelerated inactivation of cardiac L-type calcium channels triggered by anaesthetic-induced preconditioning. | Cardioprotection against ischaemia by anaesthetic-induced preconditioning (APC) is well established. However, the mechanism underlying Ca(2+) overload attenuation by APC is unknown. The effects of APC by isoflurane on the cardiac L-type Ca channel were investigated.</AbstractText>In a model of in vivo APC, Wistar rats ... |
2,324,419 | A review on the management of epilepsy associated with hypothalamic hamartomas. | Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay.</AbstractText>Without surgical intervention, the gelastic seizures, wh... |
2,324,420 | Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both? | A population of neural stem cells (NSCs) resides adjacent to the lateral ventricles in the adult mammalian brain. Despite knowledge of their existence since the early 1990s, their identity remains controversial, with evidence suggesting that they may be ependymal cells, glial fibrillary acidic protein (GFAP)-expressing... |
2,324,421 | Spontaneous resolution of cavum veli interpositi. A case report and review of the literature. | Cavum veli interpositi is an open CSF space in the roof of the third ventricle that surrounds the internal cerebral veins, and is a forward extension of the quadrigeminal plate cistern. To the best of our knowledge, spontaneous resolution of a cavum veli interpositi has not been reported in the literature to date. Inte... |
2,324,422 | Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy. | Self-renewable, pluripotent human embryonic stem cells (hESCs) can be differentiated into cardiomyocytes (CMs), providing an unlimited source of cells for transplantation therapies. However, unlike certain cell lineages such as hematopoietic cells, CMs lack specific surface markers for convenient identification, physic... |
2,324,423 | Susceptibility-weighted imaging at 3 Tesla delineates the optic radiation. | Some white matter tracts, including the optic radiation (OR), have recently been reported to be delineated as low signal intensity bands (LSBs) on T2*-weighted images at 7 T, presumably because of susceptibility effects caused by myelin.Susceptibility-weighted imaging (SWI) is more sensitive to magnetic susceptibility ... |
2,324,424 | The right ventricle in cardiac surgery, a perioperative perspective: II. Pathophysiology, clinical importance, and management. | The importance of right ventricular (RV) function in cardiovascular disease and cardiac surgery has been recognized for several years. RV dysfunction has been shown to be a significant prognostic factor in cardiac surgery and heart transplantation. In the first article of this review, key features of RV anatomy, physio... |
2,324,425 | The right ventricle in cardiac surgery, a perioperative perspective: I. Anatomy, physiology, and assessment. | The importance of right ventricular (RV) function in cardiovascular disease and cardiac surgery has been recognized for several years. RV dysfunction has been shown to be a significant prognostic factor in heart failure, congenital heart disease, valvular disease, and cardiac surgery. In the first of our two articles, ... |
2,324,426 | Serine/threonine protein phosphatases have no role in the inhibitory effects of low-frequency stimulation in perforant path kindling acquisition in rats. | The use of low-frequency stimulation (LFS) as a therapy for epilepsy is currently being studied in experimental animals and patients with epilepsy. In the present study, the role of serine/threonine protein phosphatases in the inhibitory effects of LFS on perforant path kindling acquisition was investigated in rats. An... |
2,324,427 | [Role of corticotropin releasing factor receptor 2 antisense oligodeoxynucleotide of hypothalamus in hypermetabolism in rats with severe burn]. | To observe the role of corticotropin releasing factor receptor 2 antisense oligodeoxynucleotide (CRFR2ASO) of hypothalamus in hypermetabolism in rats with severe burn.</AbstractText>Stainless-steel cannula were implanted into the 3rd ventricle. According to different medicine delivered into the 3rd ventricle, 30 SD rat... |
2,324,428 | Brain CT scan indexes in the normal pressure hydrocephalus: predictive value in the outcome of patients and correlation to the clinical symptoms. | The aim of this study is to find out the correlation of the ventricular size of the brain, as it is estimated using brain computed tomography (CT) scan indexes in patients with normal pressure hydrocephalus (NPH), to: a) the clinical symptoms, and b) the results of cerebrospinal fluid (CSF) shunting procedures. We look... |
2,324,429 | Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. | Mutations in EFHC1 gene have been previously reported in patients with epilepsies, including those with juvenile myoclonic epilepsy. Myoclonin1, also known as mRib72-1, is encoded by the mouse Efhc1 gene. Myoclonin1 is dominantly expressed in embryonic choroid plexus, post-natal ependymal cilia, tracheal cilia and sper... |
2,324,430 | Cell therapy generates a favourable chemokine gradient for stem cell recruitment into the infarcted heart in rabbits. | Stem cell recruitment into the heart is determined by a concentration gradient of stromal-derived factor 1 (SDF-1) from bone marrow to peripheral blood and from blood to injured myocardium. However, this gradient is decreased in chronic myocardial infarction (MI). This study evaluated the effect of cell therapy using b... |
2,324,431 | Infusions of acetaldehyde into the arcuate nucleus of the hypothalamus induce motor activity in rats. | The hypothalamic arcuate nucleus (ARH) is one of the brain regions with the highest levels of catalase expression. Acetaldehyde, metabolized from ethanol in the CNS through the actions of catalase, has a role in the behavioral effects observed after ethanol administration. In previous studies acetaldehyde injected in t... |
2,324,432 | Transplantation of adipose-derived stem cells overexpressing hHGF into cardiac tissue. | The delivery of adipose-derived stem cells (ADSCs) for promoting tissue repair has become a potential new therapy, while hepatocyte growth factor (HGF) is an important growth factor with angiogenic, antifibrotic, and anti-inflammatory benefits. Therefore, transplantation of ADSCs into acute myocardial infarction (AMI) ... |
2,324,433 | Optimal treatment of a recurrent giant craniopharyngioma: lessons from a case. | A case of a 33-year-old man presented with symptoms of dramatic deterioration of the level of consciousness because of a recurrence of a previously aspirated and irradiated craniopharyngioma is described. The tumor had grown enormously in dimensions and was extending in the region of hypothalamus, third ventricle and b... |
2,324,434 | [Worsening of migraine symptoms due to giant pineal cyst apoplexy]. | Although the association between headaches and pineal gland cysts has been suggested on a number of occasions, no precise evidence of exactly what this relation involves has been produced to date. It is known, however, that a cyst in the pineal gland can bring on or worsen headaches, especially if it is large or there ... |
2,324,435 | Repolarization of ventricular myocardium in atrioventricular electrical stimulation of the heart in dogs. | The duration of ventricular myocardium excitation increases during atrioventricular stimulation of dog heart and the sequence of depolarization of the right and left ventricles is desynchronized. Significant shortening of the activation-recovery interval in the intramural and subendocardial layers of the left ventricul... |
2,324,436 | On some pathogenetic and adaptation mechanisms of acute coronary disease. | Acute coronary failure was modeled in rabbits by ligation of the descending left coronary artery at the interface of its middle and lower thirds. The function and morphology of left-ventricular and right-ventricular myocardium were studied on days 1, 3, and 5 of the pathological process. It was found that left-ventricu... |
2,324,437 | Seasonal adaptation of the cardiovascular system in rabbits. | Analysis of the effects of seasonal changes in the myocardium on variability of arterial and intraventricular pressure in both ventricles showed that the objects of homeostatic regulation were the values of these parameters and their probability distribution. The adaptation mechanisms are mainly visualized by the analy... |
2,324,438 | Suprasellar hemangioblastoma. | A 59-year-old woman presented with disturbance of consciousness and decreased visual acuity caused by a suprasellar mass identified on MRI. A bifrontal interhemispheric approach allowed removal of the top and lateral sides of the tumor from the wall of the third ventricle. The hypothalamus appeared to be the origin of ... |
2,324,439 | Developmental changes in hypothalamic leptin receptor: relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat. | In the adult brain, leptin regulates energy homeostasis primarily via hypothalamic circuitry that affects food intake and energy expenditure. Evidence from rodent models has demonstrated that during early postnatal life, leptin is relatively ineffective in modulating these pathways, despite the high circulating levels ... |
2,324,440 | In vivo quantification of helical blood flow in human aorta by time-resolved three-dimensional cine phase contrast magnetic resonance imaging. | The mechanics of blood flow in arteries plays a key role in the health of individuals. In this framework, the role played by the presence of helical flow in the human aorta is still not clear in its relation to physiology and pathology. We report here a method for quantifying helical flow in vivo employing time-resolve... |
2,324,441 | The use of androgen loaded tcpl delivery devices to assess the proinflammatory cytokines profiles. | The goal of this study is to investigate the pathophysiological changes, of both local and systemic control factors (cytokines and structural alterations), associated with continuous and sustained delivery of T and DHT using tricalcium-phosphate-lysine (TCPL) delivery devices. A total of 32 adult male Sprague Dawley ra... |
2,324,442 | Strategy to eliminate inappropriate shocks secondary to T-wave oversensing in a biventricular ICD. | T-wave oversensing represents a common cause of inappropriate shocks in patients with implanted cardiac defibrillators. This case report demonstrates a strategy of device programming using V-V pace delay (sequential rather than simultaneous biventricular pacing) to eliminate T-wave oversensing without decreasing sensit... |
2,324,443 | [Comparative characteristics of some pharmacological models of chronic heart failure]. | Effectiveness and informativity of various experimental pharmacological models of the chronic heart failure (CCF) in rats have been evaluated by means of ultrasonic cardiography. It has been established that isoproterenol (INN isoprenaline) (80 mg/kg, s.c., twice with an interval of 24 h) produces compensated CCF. Mono... |
2,324,444 | The effect of enhanced gap junctional conductance on ventricular conduction in explanted hearts from patients with heart failure. | To investigate ventricular conduction and refractoriness before and after application of rotigaptide, an enhancer of gap junctional conductance, to explanted hearts of patients with heart failure (HF).</AbstractText>In six explanted perfused hearts of patients with end-stage HF, activation/repolarization mapping was pe... |
2,324,445 | Endoscopic third ventriculostomy versus ventriculoperitoneal shunt in pediatric patients: a decision analysis. | Uncertainty persists on the best treatment for patients with obstructive hydrocephalus: endoscopic third ventriculostomy (ETV) or shunt, particularly in the younger age groups. We performed decision analysis for quality of life (QOL) outcomes comparing these two procedures.</AbstractText>Frequency of outcome events for... |
2,324,446 | MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study. | Cognitive decline is one of the clinical hallmarks of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a cerebrovascular disease caused by NOTCH3 mutations. In this 7-year follow-up study, we aimed to determine whether there are associations between the different rad... |
2,324,447 | Impaired neurogenesis in adult type-2 diabetic rats. | Type-2 diabetes is an adult onset condition that affects millions of people worldwide. The ensuing hyperglycemia renders multiple organs to various complications and increases the risk of learning and memory impairment. The Goto-Kakizaki (GK) rat developed from normoglycemic Wistar-Kyoto (WKY) rat is a model for type-2... |
2,324,448 | Temporal profile of neurogenesis in the subventricular zone, dentate gyrus and cerebral cortex following transient focal cerebral ischemia. | In the adult mammalian brain, it is considered that neurogenesis persists in limited regions such as the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) of the lateral ventricle. On the other hand, neurogenesis in the cortex after cerebral ischemia and its role in post-stroke recovery have not been cla... |
2,324,449 | Visible light excitable Zn2+ fluorescent sensor derived from an intramolecular charge transfer fluorophore and its in vitro and in vivo application. | The UV- and sensor-induced interferences to living systems pose a barrier for in vivo Zn(2+) imaging. In this work, an intramolecular charge transfer (ICT) fluorophore of smaller aromatic plane, 4-amino-7-nitro-2,1,3-benzoxadiazole, was adopted to construct visible light excited fluorescent Zn(2+) sensor, NBD-TPEA. Thi... |
2,324,450 | [Seasonal changes in the composition of the titin isoforms in muscles of hibernating ground squirrels]. | An electrophoretic study of changes in the content of intact titin isoforms, N2B-, N2BA-, N2A-titins and T2 in skeletal and cardiac muscles of ground squirrel (Spermophillus undulatus) in different periods: summer activity, autumn activity, hibernation, arousal, and winter activity has been carried out. In atriums and ... |
2,324,451 | Gas-forming brain abscess caused by Klebsiella pneumoniae. | Gas forming brain abscess is a rare disease caused by Klebsiella pneumoniae occurring in patients with impaired host defense mechanism such as diabetes mellitus or liver cirrhosis. A 59-year-old man with 2-year history of diabetes mellitus and 20-year history of liver cirrhosis presented to the hospital with headache. ... |
2,324,452 | Effects of brain stem cholecystokinin-8s on gastric tone and esophageal-gastric reflex. | The actions of cholecystokinin (CCK) on gastrointestinal functions occur mainly via paracrine effects on peripheral sensory vagal fibers, which engage vago-vagal brain stem circuits to convey effector responses back to the gastrointestinal tract. Recent evidence suggests, however, that CCK also affects brain stem struc... |
2,324,453 | Prenatal infection and cavum septum pellucidum in adult schizophrenia. | Increased length of the cavum septum pellucidum (CSP) and in utero infection are each associated with increased risk of schizophrenia. Hence, we examined whether prenatal infections are related to CSP length in schizophrenia patients. In a well-characterized birth cohort, in utero infection was assessed using serologic... |
2,324,454 | [Effect of sulfur dioxide on vascular collagen remodeling in spontaneously hypertensive rats]. | To study the modulatory effect of sulfur dioxide (SO(2)) on the accumulation of collagen type I and type III in the wall of aorta during spontaneously hypertensive rat (SHR) vascular remodeling.</AbstractText>Eight male Wistar Kyoto rats at the age of 4 weeks with normal blood pressure were used as a control group. And... |
2,324,455 | Nomograms of the fetal heart between 16 and 39 weeks of gestation. | To establish the normal fetal cardiac measurement from 16 to 39 weeks' gestation in Thai fetuses.</AbstractText>Four hundred and eighty normal singleton pregnant women were recruited into the present study. The sonographic measurements were obtained from axial scans at the level of the four-chamber view.</AbstractText>... |
2,324,456 | Age-related changes in choroid plexus and blood-cerebrospinal fluid barrier function in the sheep. | Dysfunction of the choroid plexuses (CPs) and the blood-cerebrospinal fluid barrier (BCSFB) might contribute to age-related cognitive decline and neurodegenerative disease. We used the CPs from young (1-2 years), middle-aged (3-6 years) and old (7-10 years) sheep to explore effects of aging on various aspects of CP and... |
2,324,457 | Left ventricular myocardial volumes measured during arterial and delayed phases of multidetector row computed tomography: a study on intra- and interobserver variability. | To compare and correlate left ventricular (LV) myocardial volumes obtained using arterial and delayed phases of multidetector row computed tomography (CT) and evaluate their intra- and interobserver variation. Two observers evaluated the arterial- and delayed-phase serial short-axis images of 45 healthy volunteers. Int... |
2,324,458 | An evaluation of fluoroscopic times and peak skin doses during radiofrequency catheter ablation and biventricular internal cardioverter defibrillator implant procedures. | Fluoroscopy-guided medical procedures are generally diagnostic in nature and involve low dose and minimal risk to the patient. However, an increasingly larger percentage of procedures offer a therapeutic benefit to the patient. Such interventional procedures are very often technically difficult, but offer a less-invasi... |
2,324,459 | Intrinsic myoarchitectural differences between the left and right ventricles of fetal human hearts: an ultrasonic backscatter feasibility study. | Embryologically, cardiac chambers differ in their morphologic and contractile properties from the beginning. We hypothesized that a noninvasive ultrasonic backscatter investigation might illustrate the fundamental differences in myocardial morphologic properties of the 2 ventricles during heart development. The goals o... |
2,324,460 | 17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway. | Oestrogen protects against AD by multiple mechanisms, including the enhancement of Abeta clearance. Transthyretin (TTR) is a homotetrameric protein mainly synthesized by the liver and choroid plexus (CP) of the brain that sequesters the amyloid beta (Abeta) peptide. In this study we examined the effects of 17beta-estra... |
2,324,461 | Effects of methotrexate on the developments of heart and vessel in zebrafish. | Methotrexate (MTX), an antagonist of folic acid, can inhibit dihydrofolate reductase (DHFR) which is of great importance in the synthesis of tetrahydrofolic acid and embryonic development. In this study, we found that after being exposed to 1.5 mM MTX at 6-10 hours post-fertilization, zebrafish embryos fail to form nor... |
2,324,462 | Regulation of volume-regulated outwardly rectifying anion channels by phosphatidylinositol 3,4,5-trisphosphate in mouse ventricular cells. | Volume-regulated outwardly rectifying anion channel (VRAC) plays an important role in cell-volume regulation in many types of cells. Little is known about the regulation of VRAC by phosphatidylinositides (PIs), which include phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 4,5-bisphosphate (PIP2... |
2,324,463 | Effects of intracerebroventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure. | The brain melanin-concentrating hormone (MCH) system represents an anabolic system involved in energy balance regulation through influences exerted on the homeostatic and nonhomeostatic controls of food intake and energy expenditure. The present study was designed to further delineate the effect of the MCH system on en... |
2,324,464 | CGRP-alpha responsiveness of adult rat ventricular cardiomyocytes from normotensive and spontaneously hypertensive rats. | Calcitonin gene-related peptide (CGRP)-alpha is expressed in heart ventricles in sensory nerves and cardiomyocytes. It modifies inotropism and induces ischaemic preconditioning. This study investigates the effect of CGRP-alpha on the contractile responsiveness of isolated adult ventricular rat cardiomyocytes and the ef... |
2,324,465 | Transient ventriculomegaly in an adolescent presenting with shunted hydrocephalus, diabetic ketoacidosis, and hyperglycemia. | In this report, the authors describe a unique presentation of ventriculomegaly in the setting of diabetic ketoacidosis (DKA). A 15-year-old male, with a history of shunt placement for hydrocephalus and repair of a myelomeningocele, presented to the emergency room with DKA and was found to have ventriculomegaly. At the ... |
2,324,466 | Gray matter deficits in bipolar disorder are associated with genetic variability at interleukin-1 beta gene (2q13). | Twin, family and recent molecular studies support the hypothesis of genetic overlapping between schizophrenia and bipolar disorder. Brain structural features shared by both psychiatric disorders might be the phenotypic expression of a common genetic risk background. Interleukin-1 (IL-1) cluster (chromosome 2q13) geneti... |
2,324,467 | Differential numbers of foci of lymphocytes within the brains of Lewis rats exposed to weak complex nocturnal magnetic fields during development of experimental allergic encephalomyelitis. | To discern if specific structures of the rat brain contained more foci of lymphocytes following induction of experimental allergic encephalomyelitis and exposures to weak, amplitude-modulated magnetic fields for 6 min once per hour during the scotophase, the residuals between the observed and predicted values for the n... |
2,324,468 | Contrast enhancement in chest multidetector computed tomography: intraindividual comparison of 300 mg/ml versus 400 mg/ml iodinated contrast medium. | We sought to intraindividually compare intravascular contrast enhancement in multidector computed tomography (MDCT) of the chest using contrast media (CM) containing 300 and 400 mg iodine/ml.</AbstractText>Seventy-one patients underwent repeated MDCT scanning of the chest at baseline and follow-up. CM with standard iod... |
2,324,469 | Radial glia-like cells persist in the adult rat brain. | During development, radial glia cells contribute to neuronal migration and neurogenesis, and differentiate into astrocytes by the end of the developmental period. Recently, it was demonstrated that during development, radial glia cells, in addition to their role in migration, also give rise to neuroblasts. Furthermore,... |
2,324,470 | Emergency department thoracotomy for pericardiac tamponade. | A 31-year-old man with a penetrating chest injury presented acutely with pulseless electrical activity, as a result of a ventricular laceration causing pericardial tamponade. Emergency department thoracotomy was performed to release the tamponade and he was operated on immediately to repair the laceration. He subsequen... |
2,324,471 | A patient with subacute onset of ophthalmoplegia, papilledema, and proptosis. | A young man presented with headache, proptosis, and asymmetric ophthalmoplegia. He was found to have a mass in an unusual area of the brain. The differential diagnosis, diagnostic testing, pathology, treatment, and prognosis of this rare tumor are discussed in detail. |
2,324,472 | Central ghrelin affects pituitary-thyroid axis: histomorphological and hormonal study in rats. | Body weight depends on the balance between energy intake and consumption. An interaction between ghrelin and thyroid function has been reported only in pathophysiological states. We examined whether intracerebroventricular (ICV) administration of ghrelin affects the structure and function of the pituitary-thyroid axis ... |
2,324,473 | Lymphatic pump-conduit duality: contraction of postnodal lymphatic vessels inhibits passive flow. | Lymphangions, the segments of lymphatic vessels between valves, exhibit structural characteristics in common with both ventricles and arteries. Although once viewed as passive conduits like arteries, it has become well established that lymphangions can actively pump lymph against an axial pressure gradient from low-pre... |
2,324,474 | Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes. | Reduction in [Ca2+]o prolongs the AP in ventricular cardiomyocytes and the QTc interval in patients. Although this phenomenon is relevant to arrhythmogenesis in the clinical setting, its mechanisms are counterintuitive and incompletely understood. To evaluate in silico the mechanisms of APD modulation by [Ca2+]o in hum... |
2,324,475 | Heart adrenoceptor gene expression and binding sites in the human failing heart. | Adrenergic regulation of the heart function is well documented by many studies. Catecholamines act through alpha(1)-, beta(1)-, beta(2)-, and beta(3)-adrenoceptors (ARs) in the heart. There are many findings about the changes of beta(1)- and beta(2)-AR in heart failure (HF). On the other hand, the role of other AR subt... |
2,324,476 | Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. | Disorders of neuronal migration are a heterogeneous group of disorders of nervous system development. One of the most frequent disorders is lissencephaly, characterized by a paucity of normal gyri and sulci resulting in a 'smooth brain'. There are two pathologic subtypes: classical and cobblestone. Six different genes ... |
2,324,477 | Primary choroid plexus papilloma of the sacral nerve roots. | The authors describe a unique case of a choroid plexus papilloma of the sacral nerve roots. This 60-year-old woman was admitted to the hospital because of a 1-year history of sacral pain, rectal and urinary bladder retention, and paradoxical episodic incontinence. Physical examination revealed sensory abnormalities in ... |
2,324,478 | Active spontaneous decompression of a suprasellar-prepontine arachnoid cyst detected with routine magnetic resonance imaging. Case report. | Arachnoid cysts are congenital CSF collections that arise adjacent to arachnoid cisterns. These lesions can be incidental neuroimaging findings but may also cause symptoms and necessitate treatment, particularly in children. The authors present their experience with a male infant harboring a large suprasellar-prepontin... |
2,324,479 | Changes in cerebral perfusion hormone profile and cerebrospinal fluid flow across the third ventriculostomy after endoscopic third ventriculostomy in patients with aqueductal stenosis: a prospective study. Clinical article. | The object of the present study was 3-fold: 1) to study regional cerebral perfusion before and after endoscopic third ventriculostomy (ETV) in patients with obstructive hydrocephalus by using (99m)Tc ethyl cysteinate dimer SPECT: 2) to study any correlation between clinically successful third ventriculostomy and CSF fl... |
2,324,480 | Intraventricular baclofen for dystonia: techniques and outcomes. Clinical article. | The aim of this study was to evaluate the use of intraventricular baclofen (IVB) for the treatment of severe generalized secondary and heredodegenerative dystonia.</AbstractText>Nine children and 1 adult with severe dystonia unresponsive to multiple oral medications were treated with IVB. Intraventricular catheters wer... |
2,324,481 | Intracerebral cell transplantation therapy for murine GM1 gangliosidosis. | We performed a cell transplantation study to treat the brain involvement in lysosomal storage diseases. We used acid beta-galactosidase knock-out mice (BKO) from C57BL/6 as recipients. To minimize immune responses, we used cells derived from transgenic mice of C57BL/6 overexpressing the normal human beta-galactosidase.... |
2,324,482 | Reducing CSF shunt placement in patients with spinal myelomeningocele. | The incidence of hydrocephalus requiring shunts in children with myelomeningocele (MMC) is reported to be very high. Shunt-related complications are a significant cause of morbidity and mortality in this population. In order to minimize shunt placements, we used very rigid clinical selection criteria and followed them ... |
2,324,483 | Subsequent bilateral thalamic haemorrhage. | Simultaneous or subsequent bilateral thalamic haemorrhage is rare, and most reported cases are from Asian countries. An 80-year-old white Cuban man, with a history of arterial hypertension, suffered sudden onset of right hemiparesis. Computed tomography (CT) scan showed a left posteromedial thalamic haemorrhage. Two da... |
2,324,484 | A case of haemangioblastoma of the fourth ventricle presenting with depression. | Haemangioblastoma (Hab) is a rare, benign and slow-growing tumour of uncertain histiogenesis. It constitutes roughly 1% to 2% of all intracranial tumours and most commonly arises in the posterior cranial fossa: more than 80% of Habs are located in the cerebellar hemispheres, the remaining cases lie in the vermis, brain... |
2,324,485 | Malignant transformation of an intracranial germinoma into a choriocarcinoma. | The recurrence or metastasis of intracranial pure germinomas as germ cell tumours of different histological types has rarely been reported. The present report concerns the first case in the literature of intracranial recurrence of a germinoma transformed into a choriocarcinoma. A 17-year-old man presented with a 1 mont... |
2,324,486 | Acute vomiting and mental status changes: a case of acute intraventricular haemorrhage from an optic chiasm tumour. | In this article, we describe a 5- year-old girl who presented to an emergency department with 1 day of vomiting, mental status changes and decreased activity. Imaging studies revealed a mass in the optic chiasm which had haemorrhaged into her ventricles causing acute hydrocephalus. This case highlights the diligence an... |
2,324,487 | Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress. | Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease. The present study was designed to investigate the neuroprotective effects of Centella asiatica against colchicine-induced memory impairment and oxidative damage in rats. Colchicine (15 mug/5 muL) was administered intracer... |
2,324,488 | Morphological varieties of the Purkinje fiber network in mammalian hearts, as revealed by light and electron microscopy. | Purkinje fibers in mammalian hearts are known to comprise the following three groups depending on their structure: group I found commonly in ungulates, group II in humans, monkeys and dogs, and group III in rodents. The aim of the present study was to document precisely the cytoarchitecture of a network of Purkinje fib... |
2,324,489 | Refractory High Intracranial Pressure following Intraventricular Hemorrhage due to Moyamoya Disease in a Pregnant Caucasian Woman.<Pagination><StartPage>1</StartPage><EndPage>7</EndPage><MedlinePgn>1-7</MedlinePgn></Pagination><Abstract><AbstractText>Intraventricular hemorrhage during pregnancy is usually followed by a... | Intraventricular hemorrhage during pregnancy is usually followed by a poor recovery. When caused by moyamoya disease, ischemic or hemorrhagic episodes may complicate the management of high intracranial pressure. A 26-year-old Caucasian woman presented with generalized seizures and a Glasgow Coma Score (GCS) of 3 during... |
2,324,490 | 3D cardiac segmentation using temporal correlation of radio frequency ultrasound data. | Semi-automatic segmentation of the myocardium in 3D echographic images may substantially support clinical diagnosis of heart disease. Particularly in children with congenital heart disease, segmentation should be based on the echo features solely since a priori knowledge on the shape of the heart cannot be used. Segmen... |
2,324,491 | Pattern recognition of abnormal left ventricle wall motion in cardiac MR. | There are four main problems that limit application of pattern recognition techniques for recognition of abnormal cardiac left ventricle (LV) wall motion: (1) Normalization of the LV's size, shape, intensity level and position; (2) defining a spatial correspondence between phases and subjects; (3) extracting features; ... |
2,324,492 | Incompressible cardiac motion estimation of the left ventricle using tagged MR images. | Interpolation from sparse imaging data is typically required to achieve dense, three-dimensional quantification of left ventricular function. Although the heart muscle is known to be incompressible, this fact is ignored by most previous approaches that address this problem. In this paper, we present a method to reconst... |
2,324,493 | Model-based estimation of ventricular deformation in the cat brain. | The estimation of ventricular deformation has important clinical implications related to neuro-structural disorders such as hydrocephalus. In this paper, a poroelastic model was used to represent deformation effects resulting from the ventricular system and was studied in 5 feline experiments. Chronic or acute hydrocep... |
2,324,494 | Biomechanically-constrained 4D estimation of myocardial motion. | We propose a method for the analysis of cardiac images with the goal of reconstructing the motion of the ventricular walls. The main feature of our method is that the inversion parameter field is the active contraction of the myocardial fibers. This is accomplished with a biophysically-constrained, four-dimensional (sp... |
2,324,495 | Personalized pulmonary trunk modeling for intervention planning and valve assessment estimated from CT data.<Pagination><StartPage>17</StartPage><EndPage>25</EndPage><MedlinePgn>17-25</MedlinePgn></Pagination><Abstract><AbstractText>Pulmonary valve disease affects a significant portion of the global population and ofte... | Pulmonary valve disease affects a significant portion of the global population and often occurs in conjunction with other heart dysfunctions. Emerging interventional methods enable percutaneous pulmonary valve implantation, which constitute an alternative to open heart surgery. As minimal invasive procedures become com... |
2,324,496 | High-speed digital imaging of ependymal cilia in the murine brain. | The development and health of mammals requires proper ciliary motility. Ciliated epithelia are found in the airways, the uterus and Fallopian tubes, the efferent ducts of the testes, and the ventricular system of the brain. A technique is described for the motion analysis of ependymal cilia in the murine brain. Vibrato... |
2,324,497 | Analysis of the ciliary/flagellar beating of Chlamydomonas. | Eukaryotic flagella and cilia are alternative names, for the slender cylindrical protrusions of a cell (240nm diameter, approximately 12,800nm-long in Chlamydomonas reinhardtii) that propel a cell or move fluid. Cilia are extraordinarily successful complex organelles abundantly found in animals performing many tasks. T... |
2,324,498 | Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review. | Cortical and subcortical hyperintensities in magnetic resonance imaging (MRI) scans are thought to represent areas of ischemic damage to brain tissue. Researchers have focused on the possible role these lesions may have in psychiatric disorders, including bipolar disorder. In 1997, the proposed 'vascular mania' diagnos... |
2,324,499 | [Novel calretinin-positive cells with polymorphous spines in the mouse forebrain during early postnatal ontogenesis]. | Using an immunocytochemical method for calretinin (CR) detection, we have earlier described (Morfologiya, 2009 v. 135. No. 3, p. 7-19) the population of previously unknown mono- and bipolar cells with polymorphous spines (PS) covering their cell bodies and processes, in adult mice forebrain structures adjacent to anter... |
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