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26,500 | [Assessment of therapeutic equivalence of original bisoprolol and its generics
in patients with ischemic heart disease with concomitant chronic obstructive
pulmonary disease]. | Therapeutic equivalence of original bisoprolol (Concor) and its two generics
(Biprol and Biol) was studied in 102 patients with ischemic heart disease (IHD)
combined with chronic obstructive pulmonary disease (COPD). Concor, Biprol and
Biol were given for 12 weeks to 36, 36, and 30 patients, respectively. Methods
c... |
26,501 | [Value of allele gene polymorphism of the inflammation system for prognosis of
patients with myocardial infarction]. | In recent years levels of a number of inflammatory markers namely C-reactive
protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF) etc. are
measured for the purpose of postinfarction risk evaluation. Dynamics of
inflammatory markers concentrations can reflect processes occurring in
atherosclerotic plaque... |
26,502 | [The state of carotid arteries in young men with arterial hypertension]. | PURPOSE: To study elastic properties of carotid arteries in young men with
arterial hypertension (AH).
MATERIAL AND METHODS: We examined men aged 18-25 years (mean 21.1+/-0.14 years):
36 with normal blood pressure (BP), 123 with stable and 51 with unstable AH.
Parameters studied comprised intima-media thickness (IMT... |
26,503 | [Comparison of effectiveness of radiofrequency catheter ablation of left
arterial isthmuses for treatment of postablational perimitral atrial flutter]. | AIM: To compare results of radiofrequency (RF) ablation (A) of mitral and
inferior septal isthmuses in the left atrium for the treatment of perimitral
atrial flutter (AF) in patients with atrial fibrillation previously subjected to
RF isolation of pulmonary veins and modification of the left atrial anatomical
arrhy... |
26,504 | [Vitamin D in the treatment of cardiorenal syndrome in patients with chronic
nephropathy]. | AIM: To determine place of vitamin D in prevention and treatment of cardiorenal
syndrome (CRS) and chronic allograft nephropathy (CAN) in the aspect of
myocardial and renal reparation.
METHODS AND MATERIAL: In Russia and the Netherlands we included in a randomized
placebo controlled study 120 vitamin D deficient [25... |
26,505 | [Galectin 3--a new biomarker for diagnostics and outcome of chronic heart
failure]. | Galectins--lectins binding β-galactosides their properties and biological role
have been described. Galectines family in mammalians consists of 15 members.
Galectin-3 is atypical specimen of galectins family. Its participation in
fibrosis, cardiac remodeling, immune and inflammation responses have been shown.
Emplo... |
26,506 | [Heart failure: the pathogenetic continuum and biomarkers]. | Molecular aspects of pathogenesis of cardiac failure touching on transmission of
pathological signals through the transduction system, involvement of mechanisms
of transcriptional reprogramming and metabolic changes in the myocardium, as
well as processes of aging and inflammation in the pathogenetic continuum are
... |
26,507 | [31P magnetic-resonance spectroscopy in cardiac diseases]. | Magnetic Resonant spectroscopy (MRS) in the nuclei of phosphorus is the only
noninvasive method of studying the state of myocardial energy metabolism does
not require the introduction of radiopharmaceuticals. This method uses the
signals from the nuclei of 31P contained in such mattered phosphates like
phosphocreat... |
26,508 | [Comparative antiplatelet efficacy of prasugrel and high-dose clopidogrel in
patients with coronary heart disease including acute coronary syndrome]. | A number of randomized double-blind studies have been conducted for comparative
assessment of the pharmacodynamic properties of high loading and maintenance
doses of clopidogrel (600-900 mg loading dose and 150 mg maintenance dose) and
standard dose of prasugrel (60 mg loading dose and 10 mg maintenance dose) in
pa... |
26,509 | [Prognostic power of various models in determination of level of coronary risk
in patients with non ST-elevation acute coronary syndrome]. | The GRACE prognostic scale appeared ineffective for prognostication of deaths
and sum of deaths and myocardial infarctions (MI) during hospitalization and
demonstrated moderate level of prognostic value during 6 months of observation.
TIMI model gave similar result relative to prediction of death/MI/refractory
isch... |
26,510 | [Transthoracic dopllerographic assessment of the relative coronary reserve in
the norm and in the presence of isolated hemodynamically significant stenoses of
the left anterior descending coronary artery]. | Comparison of velocity parameters of blood flow and absolute coronary reserve
(absCR) in the left anterior descending and posterior interventricular coronary
arteries (ADCA and PICA) with calculation of relative coronary reserve (relCR)
and determination of its normative values was carried out with the help of
tran... |
26,511 | [CYP2C19 gene polymorphism in patients with myocardial infarction who use
clopidogrel]. | One of the foundations of the modern treatment of myocardial infarction (MI) is
a combination antiplatelet therapy consisting of acetylsalicylic acid (ASA) and
clopidogrel. Pharmacodynamic and clinical studies have demonstrated that the
polymorphism CYP2C19 (CYP2C19*2 allele) is associated with a reduced
antiplatel... |
26,512 | [Risk factors of development of left ventricular hypertrophy in patients with
hypertensive disease with high compliance to treatment]. | Aim of the study was to assess rate of development of left ventricular
hypertrophy (LVH) and its risk factors in patients with hypertensive disease
(HD) without target organs damage with high compliance to treatment. We included
in this prospective cohort study 428 patients with HD without target organs
damage. Dur... |
26,513 | [Advantages of quinapril therapy in patients with arterial hypertension and
functional class III chronic heart failure with preserved left ventricular
ejection fraction]. | AIM: To determine advantages of therapy of functional class (FC) I-II chronic
heart failure (CHF) with preserved left ventricular (LV) ejection fraction in
patients with hypertensive disease (HD) with metoprolol succinate or quinapril
and to assess their effect on regulatory-adaptive status.
METHODS: Two hundred pat... |
26,514 | [Cryoballoon ablation for pulmonary vein isolation to treat atrial fibrillation:
first experience in Russian Federation]. | Cryoballon ablation (CBA) for pulmonary vein (PV) isolation is a new method for
catheter-based treatment of patients with atrial fibrillation (AF). The purpose
of our work is to describe the CBA technique and to report its short-term
results. Methods. CBA was performed in 12 patients (8 men; age 53.1+/-5.7 years)
w... |
26,515 | [Spherical remodeling of left atrium in hypertrophic nonobstructive
cardiomyopathy]. | We examined 86 patients with various forms and variants of hypertrophic
cardiomyopathy (HCM). Examination of 69 patients with nonobstructive form of the
disease included echocardiography. The state of left atrium (LA) was studied by
measurement of its systolic and diastolic longitudinal and transversal
dimensions w... |
26,516 | [The contribution of parameters of subclinical artery wall damage in the
evaluation of cardiovascular risk]. | AIM: To assess contribution of such parameters as intima-media thickness (IMT),
presence of carotid plagues (ab), pulse wave velocity (abPWV) and ankle-brachial
index (ABI) to asessment of cardiovascular risk in patients who were initially
assigned to the group of low and moderate risk according to the SCORE scale.
... |
26,517 | [Acetylsalicylic acid in patients with planned (elective) interventions on the
coronary arteries. Risks and benefits]. | In a review of the literature describes the risks and benefits of surgical
interventions, in particular, coronary artery bypass grafting in patients with
coronary artery disease receiving antiplatelet therapy with no cancellation or
late withdrawal of acetylsalicylic acid (ASA). The data supporting a moderate -
wit... |
26,518 | [The role of direct-acting P2Y12 inhibitors in acute coronary syndrome]. | P2Y12 receptor inhibitors are recommended for treatment of patients with acute
coronary syndrome and/or percutaneous coronary intervention as a part of dual
antiplatelet therapy. While thienopyridine group of P2Y12 inhibitors remains to
be widely used treatment for patients with ACS, there are still complications
f... |
26,519 | [Arrhythmogenic right ventricular dysplasia: polymorphism of clinical
manifestations]. | We observed 15 patients with arrhythmogenic right ventricular dysplasia (ARVD):
9 with definite and 5 with probable ARVD (modified European Criteria, 2010).
Eight patients had typical ARVD (frequent right ventricular extrasystoles,
nonsustained right ventricular tachycardia without heart failure with or without
myo... |
26,520 | [Disturbances of heart rhythm in patients after myocardial infarction with
obstructive sleep apnea during outpatient rehabilitation]. | We studied specific features of heart rhythm disturbances observed during
outpatient rehabilitation of 432 patients after first myocardial infarction. In
94 of these patients (21.8%) we diagnosed obstructive sleep apnea syndrome
(OSAS). We noted substantial preponderance of pathologic ectopy related to OSAS
with mo... |
26,521 | [Acute kidney injury in patients with myocardial infarction and efficacy of
thrombolytic therapy]. | Aim of the study was to assess rate and severity of acute kidney injury (AKJ)
(RIFLE and AKIN criteria) in patients with ST-elevation myocardial infarction
(STEMI), to determine relationship between AKJ, mortality and effectiveness of
thrombolytic therapy (TLT). We examined 146 patients (117 men, 29 women, mean
age... |
26,522 | [Cystatin C and bleedings during hospitalization of noninvasively treated
patients with acute coronary syndromes]. | PURPOSE: To assess relationship between blood level of a marker of renal
function cystatin C (CC) and bleeding events in patients with acute coronary
syndromes (ACS).
MATERIAL AND METHODS: CC level was measured in 160 patients from the ACS
registry conducted in a noninvasive hospital in Moscow. Each month we include... |
26,523 | [Clinico-economical aspects of cardioversion of paroxysmal atrial fibrillation
at phehospital stage and during hospitalization]. | We carried out clinico-economical analysis of 2 tactics of rhythm restoration in
patients with paroxysmal atrial fibrillation (AF) lasting less than 48 hours:
cardioversion at prehospital stage with intravenous procainamide and inhospital
cardioversion with any method. This retrospective study was based on the data ... |
26,524 | [Asymptomatic ventricular pre-excitation in children: a 17 year follow-up
study]. | Results of long term clinic-electrophysiological follow-up of a large group of
children with Wolf-Parkinson-White (WPW) phenomenon are present. From 1993 to
2011 we examined 176 children - 117 boys (66,5%) and 59 girls (33,5%) - with
manifesting type of WPW. Age at first examination was 12.5+/-3.2 ( 0.1 18 ). In
66... |
26,525 | [Inflammatory-destructive biomarkers of atherosclerotic plaques instability.
Study of arterial wall and blood]. | Concentrations of tumor necrosis factor, interleukin 1- and its receptor
antagonist, IL-6, IL-8, IL-18, IL-2, ligand of CD40 receptor (CD40L), high
sensitive C-reactive protein (hsCRP), monocyte chemotactic protein -1,
endothelial monocyte activating protein II, adhesive molecules (sICAM-1 and
sVCAM-1), matrix meta... |
26,526 | [Isolated elevation of troponin-T level after percutaneous coronary
interventions: clinical significance]. | Relationship between isolated elevation of troponin-T (Tn-T) level after
percutaneous coronary interventions (PCI) and remote outcomes was studied in 124
patients with ischemic heart disease with normal level of creatine kinase MB
fraction after elective PCI. Blood samples for measurement of markers of
myocardial n... |
26,527 | [Clinical features and history of vasovagal syncope]. | Aim of this investigation was to study special characteristics of natural course
of vasovagal syncope (VVS). During 3 years we examined 212 patients (44% men) in
accordance with recommendations of European Society of Cardiology using tilt
tests according to Westminster or Italian protocols for confirmation of
vasov... |
26,528 | [Broadened indications for the use of selective β-adrenoblockers]. | Broadened Indications to the prescription of selective -adrenoblockers in
international and European recommendations are considered in this review.
Selective β-adrenoblockers have been shown to possess both good antihypertensive
and neutral metabolic actions. Bisoprolol does not worsen lipid, carbohydrate
metabolis... |
26,529 | [Pre-operative cardiac risk assessment and perioperative cardiac management in
non-cardiac surgery]. | More than 230 million surgical operations are performed yearly in the world and
this number is continually growing. Thirty days mortality in moderate and high
risk non-cardiac surgery is about 2% and exceeds 5% in patients with high
cardiac risk. European Society of Cardiology (ESC) issued specific guidelines in
20... |
26,530 | [Predictors of non-fulfillment of reperfusion therapy in patients with
ST-elevation acute coronary syndrome]. | At present reperfusion therapy in ST-elevation (STE) acute coronary syndrome
(ACS) is carried out in majority of countries not more than in 70% of cases. We
analyzed predictors of non-fulfillment of reperfusion therapy in patients with
STEACS included into ACS registry conducted in the Kemerovo cardiological
dispen... |
26,531 | [Prognostic significance of platelet metabolism in patients with cerebrovascular
complications of hypertension in combination with coronary heart disease]. | The study of hemostasis and NAD(P)-dependent platelet dehydrogenases activity
was made in 90 patients with cerebrovascular complications (development of
ischemic stroke) of hypertension and coronary heart disease. On the basis of
NADP-dependent platelet dehydrogenases activity we suggested a mode of
prognostication... |
26,532 | [Relationship between the structure-functional state of the heart and brain
natriuretic peptide level in patients with arterial hypertension]. | We studied relationship between structure-functional parameters of left and
right cardiac chambers and N-terminal pro-brain natriuretic peptide (NT-proBNP)
level in 118 patients with arterial hypertension (AH) (35 men, 83 women) and 17
healthy volunteers. Methods comprised 24-hour arterial pressure monitoring
(APM)... |
26,533 | [Endogenous sex hormone testosterone and haemostatic factors in young men after
myocardial infarction]. | OBJECTIVES: To compare levels of haemostatic factors and sex hormones in young
men after myocardial infarction, to study relationship between sex hormones and
factors of hemostasis.
METHODS: We studied 32 men aged 30-50 years with diagnosis of myocardial
infarction. Patients were divided into 2 groups according to a... |
26,534 | [Prevalence of multifocal atherosclerosis in different age groups]. | Aim of the study was to assess prevalence of lesions in several arterial beds in
patients with atherosclerosis of various localization in the clinic of
cardiovascular surgery. We examined 1018 patients (825 men and 193 women, aged
31-78 years, mean age 59+/-12 years) in the period of preparation to elective
surgica... |
26,535 | [Periportal cardiomyopathy. Some peculiarities of clinical picture and course of
the disease]. | Results of the study of special characteristics of the course of chronic heart
failure (CHF) in women with periportal cardiomyopathy (PCMP) are presented. We
have found that prevalence of PCMP in the structure of dilated cardiomyopathy is
9.5%. PCMP compared with idiopathic cardiomyopathy is characterized by less
p... |
26,536 | [Analysis of causes of pulmonary artery embolism hypodiagnostics at prehospital
stage]. | Aim of the study was to analyze causes of pulmonary artery thromboembolism
(PATE) hypodiagnostics at prehospital stage. We compared clinical and
electrocardiographic picture of acute period of the disease in groups of
patients with diagnosed (n=61) and undiagnosed (n=22) PATE at prehospital stage.
We also assessed ... |
26,537 | [Effect of short term graded physical exercise on the level of glycemia in
children and adolescents with type 1 diabetes mellitus: data of long term ECG
monitoring and registration of motor activity]. | Study aim was to elucidate effect of graded physical exercise on glycemia level
and interval QT duration in children and adolescents with type 1 diabetes
mellitus. We carried out 25-hours parallel monitoring of glycemia, ECG and
physical activity in 15 children and adolescents aged 9-17 years. During
monitoring the... |
26,538 | [The role of oxidative processes in augmentation of atherogenity of low density
lipoprotein particles]. | We investigated action of natural dicarbonyl compounds which are formed in
atherosclerosis and diabetes on properties of low density lipoproteins (LDL)
such as surface charge, conformational changes of apoB100, susceptibility to
oxidation. and aggregation rate. It was found that malonic dialdehyde (MDA)
compared wi... |
26,539 | [Remodeling of vascular bed in patients with arterial hypertension:
possibilities of diagnostics and correction]. | Arterial hypertension determines the remodeling of the vascular bed at all
levels, resulting in a high risk of developing cardiovascular complications.
Recent studies performed on the basis of evidence-based medicine, demonstrated
the high efficiency of the combination drug therapy with perindopril and
amlodipine i... |
26,540 | [Diagnostic value of small concentrations of troponin in patients with
myocardial infarction]. | We have reviewed here studies of measurement of small concentrations of troponin
in patients with myocardial infarction conducted in 2010-2011 which were most
significant for the clinic. Troponin is a most specific and sensitive
cardiomarker appearance of which in blood serum evidence for a necrotic process
in card... |
26,541 | [Bisoprolol: opportunities in the treatment of hypertension]. | Bisoprolol (bisoprolol fumarate) - -cardioselective blocker, does not possess
intrinsic sympathomimetic and membrane stabilizing activity. The main
indications for bisoprolol are arterial hypertension (AH) and heart failure.
This article provides an overview of the literature on the potential uses of
bisoprolol in ... |
26,542 | [Clinical and prognostic significance of multifocal atherosclerosis in patients
with acute coronary syndromes without ST-segment elevation]. | Aim of the study was to determine incidence of multifocal atherosclerosis (MFA),
to assess its clinical and prognostic significance in the hospital phase in
patients with non-ST elevation acute coronary syndrome (NSTEACS). We studied
data from 225 patients with duration of NSTEACS 48 hours or less, who along with
u... |
26,543 | [Efficacy of early invasive strategy of diagnostics and treatment of unstable
angina at the background of preexisting ischemic heart disease]. | Study aim was assessment of efficacy of early invasive tactics of treatment of
patients with various forms of unstable angina at the background of preexisting
ischemic heart disease. We compared noninvasive and invasive estimation of risk
in 354 patients admitted to the N.V.Sklifosofsky Institute of Urgent Aid in 20... |
26,544 | [Effect of ω-3 polyunsaturated fatty acids on predictors of sudden cardiac death
in patients with ischemic heart disease and ventricular rhythm disturbances]. | OBJECTIVE: To assess the dynamics of non-invasive electrophysiologic
(ventricular arrhythmias, HRV, HRT, mTWA) and humoral (red blood cells ω-3
index) SCD predictors at the background of therapy with ω-3 PUFA in patients
with iscemic heart disease and ventricular arrhythmias.
MATERIALS AND METHODS: The study include... |
26,545 | [Complex of genotypes of cytokines as a genetic factor of risk of development of
myocardial infarction of in Europien population of Russia men]. | Cytokines as regulators of activity of inflammation play significant role in
mechanisms of formation of atherosclerotic plaques and in processes of their
destabilization. One of leading genetic factors determining level of their
production appears to be polymorphism of cytokine genes structure at their
promoter loc... |
26,546 | [24-Hour arterial pressure variability and 24-hour variability of pulse carries
unidirectional character and is not associated with left ventricular hypertrophy
(results of population study)]. | Alternative prognostic interpretation of variability of arterial pressure (AP)
and pulse seems contradictory if one considers classical conceptions of close
physiological connection between AP and pulse. It is logical to expect that
elevated variability of AP should be associated with elevated variability of
pulse ... |
26,547 | [Vegetative status in pregnant and perimenopausal women with hypertension]. | We observed 137 patients, 72 of whom (53%) had hypertension in II trimester of
pregnancy, and 65 patients (47%) who had hypertension in perimenopausal period.
The comprehensive clinical and instrumental examination was carried out in all
patients, including simultaneous 24-hour ambulatory blood pressure (BP)
record... |
26,548 | [Association of parameters of heart rate variability with severity of bronchial
obstruction and presence of pulmonary hypertension in patients with chronic
obstructive pulmonary disease]. | With the aim of assessing parameters of heart rate variability (HRV) and heart
rhythm turbulence (HRT) in patients with chronic obstructive pulmonary disease
(COPD) in dependence on severity of the course of this disease and presence of
pulmonary hypertension (PH) we examined 73 patients (28 with COPD and 45 healthy... |
26,549 | [Comparison of the effectiveness of pulmonary veins isolation vs linear
radiofrequency ablation in paroxysmal atrial fibrillation patients using either
mathematical scanning or clinical approach]. | AIM: to compare clinical results of linear ablation vs. PVI approach in patients
with paroxysmal AF and to estimate theoretical probability of 4-waves re-entry
to eliminate as a results of the both ablative techniques formatting by means
left atrial geometry two-dimensional mathematical modeling.
MATERIAL AND METHOD... |
26,550 | [Comparison of three methods of antithrombotic therapy in elderly patients with
nonvalvular atrial fibrillation]. | We compared efficacy and safety of warfarin, direct thrombin inhibitor
dabigatran and clopidogrel in prevention of stroke in 210 patients with
nonvalvular atrial fibrillation (AF) aged 65-80 years. The use of dabigatran
(110 mg twice daily) for 12 months or warfarin was associated with similar rate
of ischemic stro... |
26,551 | [Heart rate variability in the prognosis of tilt-testing results]. | Study aim was assessment of dynamics of spectral parameters of heart rate
variability (HRV) during the Westminster and Italian protocols of tilt-test
(TT). We included in this study 114 patients with recurrent vasovagal syncope
(VVS). Basing on TT results we distinguished 4 groups of patients: with positive
result ... |
26,552 | [The experience of the application of ascorbinic acid as antioxidant after
coronary artery surgery with use of cardiopulmonary bypass]. | We have studied the role of oxidant stress in development of rhythm disturbances
in early postoperative period after coronary artery bypass grafting and
possibilities of their prevention with preparations of ascorbinic acid. It was
shown that the use of β-adrenoblockers allows to prevent arrhythmia on first day
aft... |
26,553 | [Histiocytoid cardiomyopathy in an infant]. | We present a description of a clinical observation of a histiocytoid
cardiomyopathy in a female patient aged 4 months. This pathology is rare in
pediatric cardiology. Its etiology is linked with mutation of the gene encoding
mitochondrial cytochrome B (mitochondrial transport of electrons). This mutation
leads to a... |
26,554 | [Acute non ST-elevation coronary syndrome in real practice of hospitals in
Russia. Comparative data from RECORD 2 and RECORD registries]. | AIM: to compare data on pre- and in hospital treatment of non ST-elevation
(NSTE) acute coronary syndromes (ACS) in Russian ACS registers RECORD
(recruitment from 11.2007 to 02.2008) and RECORD-2 (from 04/2009 to 04.2011).
MATERIAL: Four of 7 hospitals participating in RECORD-2 were invasive (57.1% vs.
55.6% in RECO... |
26,555 | [Effectiveness and safety of losartan and its combination with
hydrochlorothiazide in patients with hypertension: in result study]. | There are limited data on the results of Russia's use of losartan in clinical
practice for the treatment of patients with arterial hypertension (AH). The
purpose of the study was to assess the efficacy and safety of losartan and its
fixed combination with hydrochlorothiazide (HCTZ) in patients with hypertension.
Pr... |
26,556 | [Anxiety-depressive States in elderly patients with chronic heart failure]. | Aim of the study was determination of factors of social desadaptation, which
negatively affect psychoemotional status and quality of life of elderly patients
with chronic heart failure (CHF). We included into the study 248 patients aged
60-85 years and 82 patients aged 39-59 years with NYHA class II-IV CHF. General ... |
26,557 | [Awareness of physicians about the causes of heart failure in hypertensive
patients]. | We studied awareness of physicians of the city health clinics (polyclinics)
about the causes of heart failure in hypertensive patients and their attitude to
the prevention of complications of hypertension. The study involved 194 general
practitioners from five regions of Russia. The questionnaire method in the form ... |
26,558 | [Functional reserves of the heart under conditions of alimentary magnesium
deficit]. | Aim of the study was to assess functional reserves of myocardium in animals with
deficit of magnesium during stress tests. Magnesium deficit was modeled by 10
week long magnesium deficient diet. After 54% lowering of magnesium level in
erythrocytes we registered left ventricular pressure, myocardial contraction and ... |
26,559 | [The integrated approach to diagnostics of metabolic syndrome in clinical
practice]. | Basic criteria of diagnostics and definitions of metabolic syndrome recommended
by various international associations and expert groups are discussed. Permanent
changes of criteria and usage of various approaches to diagnostics influence
prevalence of metabolic syndrome among populations and estimation of its
assoc... |
26,560 | [Individual coronary heart disease risk prediction as part of primary
prevention]. | Correction of traditional risk factors (RF) at the population level resulted in
considerable progress in prevention of coronary heart disease (CHD) in many
countries. At the same time existing approaches to individual prediction of
cardiovascular diseases based on the analysis of traditional RF and global risk
scor... |
26,561 | [The environment as a risk factor of coronary heart disease in urbanized region
with developed chemical industry]. | Tendency to growth of prevalence of ischemic heart disease (IHD) occurring in
Russian Federation despite application of preventive measures designates
necessity of search for novel nontraditional factors of risk. Among other
studied factors of genesis of cardiovascular diseases in general and of IHD in
particular i... |
26,562 | [Sudden death of two sisters in a family with combined progressive impairment of
cardiac conduction system]. | Sudden cardiac death (SCD) of two sisters from a family with combined
progressive impairment of cardiac conduction system (CCS) is described. These
two sisters (hetero-ovular twins) died suddenly in a kindergarten at the
background of physical and emotional effort in the age of 4.8 and 5 years.
Resuscitation and el... |
26,563 | [Comparative efficacy of conservative and invasive treatment of patients with
stable form of ischemic heart disease (according to results of five year
prospective study)]. | Despite high immediate efficacy of percutaneous coronary interventions (PCI) in
relation to symptoms of angina the problem of influence of this method of
treatment on duration of life and prognosis in stable ischemic heart disease
(IHD) remains unsolved. Aim of our study was to compare efficacy of conservative
ther... |
26,564 | [The role of markers of inflammation in assessment of prognosis in patients with
ST-elevation myocardial infarction combined with disturbances of carbohydrate
metabolism]. | Diabetes mellitus (DM) is not only an independent risk factor (RF) of
development of atherosclerosis, but it substantially worsens prognosis of
patients with acute myocardial infarction (MI). Results of this study evidence
that presence of disturbances of carbohydrate metabolism (DM or impaired glucose
tolerance (I... |
26,565 | [Assessment of the prognostic value of the CRUSADE score in patients with acute
coronary syndromes hospitalized in a noninvasive hospital]. | Background. The CRUSADE score was created for assessment of bleeding risk in
patients with acute coronary syndrome (ACS). However its accuracy was not
confirmed in populations of patients treated in Russian hospitals, in
noninvasively managed patients, in patients without myocardial infarction (MI).
Aim. To assess ... |
26,566 | [Effect of various types of antihypertensive therapy on elasticity of arterial
wall in elderly patients with hypertensive disease and nonvalvular atrial
fibrillation]. | Basing on the data of ultrasound study we compared effects of various
antihypertensive therapies on elastic properties of common carotid arteries and
the thoracic aorta in 133 patients aged 65-80 years with nonvalvular atrial
fibrillation (AF). The use of perindopril, lercanidipin, valsartan and its
combination wit... |
26,567 | [Biomarkers of inflammation in patients with chronic heart failure and implanted
devices for cardiac resynchronization therapy]. | The aim of the study was to assess the relationship between N-terminal pro-brain
natriuretic peptide (NT-proBNP) and inflammatory markers in patients with
congestive heart failure (CHF) treated with cardiac resynchronization therapy
(CRT). 97 patients (age 54.9+/-9.9 years; 87% men) with implanted CRT devices
(medi... |
26,568 | [Special features of coronary artery involvement in women with rheumatoid
arthritis]. | Aim of the study was to assess the state of coronary arteries and to reveal
peculiarities of their involvement in women with rheumatoid arthritis (RA). We
examined 51 women: 30 patients with RA and 21 women of the control group.
Average age of patients with RA was 49+/-7.4, of control subjects - 47+/-9
years. Exami... |
26,569 | [Gender peculiarities of development of atherosclerosis and impairment of brain
oxygen supply in excessive body weight]. | Aim of the given study was to elucidate special characteristics of mechanisms of
development of atherosclerosis and supply of oxygen to the brain in overweight
men and women. We included into this study 80 patients with multifocal
atherosclerosis without history of myocardial infarction. We analyzed parameters
of b... |
26,570 | [Relationship between carotid artery intima media thickness and risk factors of
cardiovascular diseases in young men]. | Positive correlation between age, leading risk factors of cardiovascular
diseases (CVD), and carotid artery intima-media thickness (IMT) has been shown
in numerous studies. Contingent of the present work was a part of long term
cohort study initiated in 1983. We included in analysis data from 233 men in 120
of whom... |
26,571 | [Functional properties of endothelium of peripheral vessels in adolescents]. | In a random sample of adolescent schoolchildren (n=204) we assessed functional
state of endothelium of brachial artery by test with reactive hyperemia. The
data obtained was compared with values of arterial pressure and nutritional
status of these adolescents and results of questionnaire survey of their parents
con... |
26,572 | [Assessment of fractional coronary blood flow reserve]. | Coronary angiography despite all its advantages has a number of limitations. In
some cases some supplementary means (methods of visualization such as
intravascular ultrasound, optical coherent tomography, as well as determination
of functional significance of atherosclerotisc lesions by means of measurement
of frac... |
26,573 | [Features of urapidil in treatment of resistant hypertension]. | The review considers the possibility of using capsule form urapidila for
combination therapy for treatment-resistant hypertension. The drug has a dual
mechanism of action and combining the properties of -blockers and centrally
acting drug, has a high efficiency, comparable to that of other groups of drugs,
and good... |
26,574 | [Postoperative dynamic changes in matrix metalloproteinase levels in patients
with coronary artery bypass graft procedure complications]. | The purpose of this study was to evaluate diagnostic and prognostic value of
matrix metalloproteinases in postoperative complication development after
on-pump coronary artery bypass grafting. 29 coronary artery disease patients who
had undergone on-pump coronary artery bypass grafting were examined, 4 of those
had ... |
26,575 | [Vascular effects of perindopril arginine and indapamide fixed combination in
patients with arterial hypertension]. | The aim of the study was to investigate the dynamics of arterial stiffness and
endothelial function parameters under the influence of perindopril arginine and
indapamide fixed combination in arterial hypertension (AH) patients. 30 persons
with 1-3 degree AH were included into the study. The treatment duration was 24... |
26,576 | [Changes of QT interval during graded exercise test in healthy adolescents aged
11-15 years]. | Aim of the study was determination of physiological limits of QT-intervals and
its derivative values in healthy children and adolescents during graded exercise
tests. We examined 100 healthy boys and girls aged 11-15 years (mean age
13.4+/-2.1 years) and performed electrocardiography at rest and standard
veloergome... |
26,577 | [The value of compliance during chronic administration of acetylsalicylic acid
in patients with acute coronary syndrome: results of the study FORPOST]. | Found low compliance of admission to long-term acetylsalicylic acid (ASA) in
patients with acute coronary syndrome (ACS): 74.9% of patients reported that the
suspended or completely stopped taking the drug, and only 16.2% were fully
committed to the long-term therapy with ASA. Patients are significantly more
likely... |
26,578 | [Contemporary outlook on prevention and correction of early disturbances of
carbohydrate metabolism in cardiological practice]. | In the search for effective means of prevention and detection of early markers
of type 2 diabetes mellitus (DM) the scientists take an interest for early
disturbances of carbohydrate metabolism. In this work we present data of
international clinical studies confirming that early disturbances of
carbohydrate metabol... |
26,579 | [Pharmacogenetics of clopidogrel and its clinical significance]. | The review is devoted to pharmacogenetics of clopidogrel and its value for the
clinic. Mechanism of action of clopidogrel and main trials which has proven its
efficacy are presented as well as results of main large studies including
authors own results demonstrating dependence of clinical efficacy of clopidogrel
on... |
26,580 | [The problem of the effectiveness of treatment of arterial hypertension in
smokers]. | In this review we give short characteristics of investigations devoted to
assessment of effectiveness of cardiac drugs in patients who smoke. Basing on
results of these investigations point of view is expressed that antihypertensive
preparations of various classes differently affect smokers with arterial
hypertensi... |
26,581 | [Magnesium in the treatment and prevention of cerebrovascular disease]. | To date, the amount of evidences for the role of magnesium in determining the
energy potential of the cells increases, which is critical in the pathogenesis
of stroke, as well as in the survival and recovery of brain cells. Energy donor
in cellular processes is adenosine triphosphate (ATP) as a complex of Mg2+- ATP ... |
26,582 | [Effect of nicotine and tar present in cigarette smoke on the process of
atherogenesis]. | Tobacco smoking is a major risk factor of the development of atherosclerosis and
thrombosis. Components of tobacco smoke induce changes in the function of
thrombocytes, endothelium, macrophages and smooth muscle cells of blood vessels.
Smoking causes changes in activity of enzymes of antioxidant system by inducing
... |
26,583 | [Myocardium non-compaction]. | The left ventricular non-compaction (spongy cardiomyopathy) is a rare, poorly
known pathology. Disease according to WHO classification applies to unclassified
cardiomyopathy. Clinical picture is nonspecific. Diagnosis is established by
means of instrumental techniques such as echocardiography and magnetic resonance ... |
26,584 | [Adherence of patients with stable angina to treatment with trimetazidine MR and
frequency of emergency medical care: results of the EFFECT study]. | The adherence of patients with stable angina to antianginal therapy is the key
factor of controlling the disease. The purpose of the study was to evaluate the
relationship of adherence of patients with stable angina to treatment with
trimetazidine modified release (MR) with frequency (risk) of emergency medical
car... |
26,585 | [Comparative assessment of risk factors and hospital results in male and female
patients underwent to coronary artery bypass surgery]. | There are controversial data on relatively unfavorable effect of female gender
on postoperative mortality of patients underwent to coronary artery bypass
grafting (CABG). In order to assess risk factors and hospital outcomes after
elective CABG we studied retrospectively data on patients who had undergone CABG
in S... |
26,586 | [Noncompaction myocardium as a primary phenomenon or consequence of myocardial
dysfunction: clinical masks of the syndrome]. | Noncompaction myocardium (NCM) is a genetic heterogeneous primary cardiomyopathy
which affects both children and adults and can be either isolated or combined
with other congenital heart disorders. It has common pathogenesis of symptoms
but is distinguished by pronounced clinical polymorphism. We have observed 25
a... |
26,587 | [Effect of type 2 diabetes mellitus on extent of multifocal atherosclerosis in
patients with ischemic heart disease]. | Aim of the study was investigation of influence of diabetes mellitus (DM) on
rate of detection of multifocal atherosclerosis (MFA) in patients with ischemic
heart disease (IHD) at examination before coronary artery bypass grafting
(CABG). We retrospectively analyzed 2411 hospital forms of patients with IHD
subjecte... |
26,588 | [Contemporary trends of genetic analysis in hypertrophic cardiomyopathy]. | Subject of great interest of contemporary scientific community is a search for
additional genetic and environmental factors which are capable to influence
formation of a clinical variant of the course of hypertrophic cardiomyopathy
(HCMP). It has been shown by many works that besides mutations in genes of
sarcomere... |
26,589 | [Collateral blood flow in the myocardium: the role of endothelial growth
factor]. | Collateral blood flow is a natural way of compensation of blood supply of
ischemic myocardium however its efficacy is highly individual. Revelation of
potentially modifiable factors acting on which it would be possible to change
the state of collateral blood flow will allow to find an approach to improvement
of pro... |
26,590 | [New class III antiarrhythmic drugs for treatment of atrial fibrillation]. | Last two decades have been dedicated to intensive search for new class III
antiarrhythmic drugs, especially for atrial fibrillation. Here we present a
review of the status this problem. Influence on transmembranous ion currents and
mechanisms of antiarrhythmic action are described. Results of experimental and
clini... |
26,591 | [Fatal coronary artery spasm in a patient with thyrotoxicosis]. | According to some data up to 20% of patients with thyrotoxicosis suffer from
vasospastic angina. But presence of coronary artery spasm can be rarely
confirmed. We describe a case of development of spasm of coronary arteries in a
patients with severe thyrotoxicosis. Despite active treatment of thyrotoxicosis
and use... |
26,592 | [Association of ischemic heart disease with some psychosocial risk factors in
male population aged 25-64 years]. | Aim of the study was elucidation of association between prevalence of ischemic
heart disease (IHD) with high levels of psychosocial risk factors in open male
population aged 25-64 years. We examined a representative sample of men aged
25-64 years formed from electoral lists in one of administrative districts in
Tyu... |
26,593 | [Influence of ω-3 PUFAs on predictors of sudden cardiac death in patients with
Q-wave myocardial infarction]. | OBJECTIVE: To assess effect of ω-3 polyunsaturated fatty acids (PUFAs) on
non-invasive predictors of sudden cardiac death (ventricular arrhythmias, QT
duration and variability, late ventricular potentials [LVP], microvolt-level
T-wave alternans [MTWA], and heart rhythm turbulence [HRT]) in patients with
Q-wave myoc... |
26,594 | [Risk factors and the course of myocardial infarction in elderly women]. | AIM: to elucidate risk factors and special features of myocardial infarction
(MI) in elderly women.
MATERIAL AND METHODS: We included into the study 217 women aged 34 to 89 years
who had Q-wave or non Q-wave MI and were admitted for treatment in the
cardiology department. These patients were divided into two age gro... |
26,595 | [Remodeling of left ventricular myocardium at early stages of essential arterial
hypertension in adolescents]. | We studied geometric changes of the left heart in 299 teenagers aged 12-18 years
with essential arterial hypertension (EAH). According to 24-hour blood pressure
monitoring all patients were divided into three groups: patients with phenomenon
of "white coat hypertension" (WCH, n=98); patients with labile arterial
hy... |
26,596 | [The role of transforming growth factor-β in the pathogenesis of mitral valve
prolapse]. | Changes in activity of the components of TGF-β signaling pathway is associated
with inherited disorders of connective tissue such as Marfan syndrome,
Loeys-Dietz syndrome, etc. However, its impact on mitral valve prolapse (MVP)
has not been completely studied. We examined 35 patients undergoing
reconstructive surge... |
26,597 | [Determination of phases of stress in clinical cardiology]. | Aim of the study was to determine criteria of phases of stress reaction in
humans to psychoemotional loading taking into account regulatory systems of
adaptational reserves of organism. We examined representatives of professions
potentially exposed to stress and investigated a spectrum of derangements of
regulatory... |
26,598 | [Molecular mechanisms of thrombogenesis]. | Platelets are the key elements of hemostasis and optimal model for analysis of
normal and altered mechanisms of thrombogenesis. Adhesion of platelets is
initiated by von Willebrand factor, collagen, fibronectin, thrombospondin and
laminin through GP VI, GPIb-V-IX complex, integrine receptors α(2)β(1), α(IIb)β,
and ... |
26,599 | [The place of β-adrenoblockers in the treatment of cardiovascular disease in
patients with chronic obstructive pulmonary disease]. | Review is devoted to the place of β-adrenoblockers in the treatment of
cardiovascular disease (CVD) in patients with chronic obstructive pulmonary
disease (COPD). Currently, it is expedient to use cardioselective
-adrenoblockers, such as bisoprolol, metoprolol succinate, carvedilol and
nebivolol for the treatment o... |
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