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26,600 | [Lercanidipine in the treatment of arterial hypertension]. | This review summarizes data on the effectiveness of lercanidipine. Lercanidipine
is dihydropyridine calcium antagonist of the third generation, characterized by
high vazoselective, long duration of action and good antihypertensive effect. It
may be assigned to elderly patients with isolated hypertension and has seve... |
26,601 | [Coronary stenting in patients with ischemic heart disease with multivessel
involvement of coronary vascular bed and low Syntax score]. | MATERIAL AND METHODS: We followed 619 patients with ischemic heart disease (IHD)
and multivessel involvement of coronary arteries: 317 patients subjected to
coronary artery bypass grafting (CABG, group 1) and 302 patients subjected to
multivessel percutaneous coronary intervention (PCI, group 2) with implantation
o... |
26,602 | [Comparative efficacy of pharmacoinvasive strategy of myocardial reperfusion and
primary angioplasty in patients with acute ST elevation myocardial infarction]. | In order to assess comparative efficacy of pharmacoinvasive strategy of
myocardial reperfusion and primary angioplasty in ST elevation acute myocardial
infarction 289 patients were randomized at prehospital stage within first 6
hours of the disease into 2 groups: primary angioplasty (group 1), and
prehospital throm... |
26,603 | [The role of genetic factors in the prediction of myocardial infarction
complications within one year follow up]. | A sample of 165 patients with myocardial infarction (MI) with ST segment
elevation has been studied to construct a prediction model for one-year period
complications (recurrent nonfatal IM or cardiac death). Polymorphic genetic
markers (n = 32) with confirmed role in pathogenesis of cardiovascular disease
were anal... |
26,604 | [Organoprotective and metabolic effects of S-amlodipine in patients with
arterial hypertension]. | We compared effects of racemic amlodipine and S-amlodipine in 127 patients with
1-2 degree arterial hypertension (AH) on structural-functional parameters of the
left ventricle and brachial artery as well as on characteristics of
carbohydrate, lipid, electrolyte, and purine metabolism. Racemic amlodipine was
given t... |
26,605 | [Realities and perspectives of stroke prevention in atrial fibrillation:
physician's opinions analysis]. | The purpose is to study the opinions of general practitioners and cardiologists
on the issue of stroke prevention and the prospects of new oral anticoagulants
treatment of patients with atrial fibrillation (AF). 240 physicians, of whom 139
were general practitioners and 101 cardiologists, were questioned. The
physi... |
26,606 | [Potassium-preserving properties of magnesium]. | Current fundamental research indicates importance of conducting clinical studies
of the influence of magnesium content of the body on the potassium homeostasis.
In this work we systematically analyze molecular mechanisms through which
magnesium regulates potassium homeostasis: ATP-sensitive inward rectifier
K-chann... |
26,607 | [Treatment of patients with chronic heart failure based on monitoring of
concentrations of natriuretic peptides--to what extent it is justified in
clinical practice?]. | The review is devoted to consideration of novel pathways of treatment of
patients with chronic heart failure (CHF) in particular of the high risk group.
All main studies of the problem of treatment of patients with CHF based on
monitoring of concentration of natriuretic peptides (MCNUP) BNP or NT-proBNP
have been a... |
26,608 | [The strategy, tactical approaches and choice of combination therapy in the
treatment of patients with arterial hypertension]. | This review article presents approaches to the selection of strategy of
antihypertensive therapy in hypertensive patients according to the degree of
elevation of blood pressure (BP), the level of risk for cardiovascular
complications, the doses of drugs used in accordance with current guidelines. A
comparative anal... |
26,609 | [Blockers of renin-angiotensin-aldosterone system in the treatment of arterial
hypertension: classics versus the modern]. | According to results of large clinical studies angiotensin II receptor blockers
(ARB) and aliskiren do not lower risk of cardiovascular complications and
mortality in wide spectrum of clinical conditions and are able to worsen renal
outcomes. It is expedient to prefer inhibitors of angiotensin converting enzyme
in ... |
26,610 | [Factors associated with mitral regurgitation in men with ischemic heart disease
without myocardial infarction]. | Being independent predictor of cardiovascular mortality, mitral regurgitation
(MR) has a negative influence on prognosis of ischemic heart disease (IHD)
patients. Data on MR pathogenesis in IHD patients without myocardial infarction
(MI) are insufficient.
PURPOSE: To reveal factors associated with MR in CAD men with... |
26,611 | [Prehospital management of patients with acute coronary syndrome in Moscow. Data
of the first Moscow "snapshot" register]. | AIM: To characterize the state of prehospital management of patients with acute
coronary syndromes (ACS) using data from Moscow snapshot registry of
hospitalized patients with ACS.
METHODS: The registry included data on consecutive patients with ACS admitted to
coronary care units or their equivalents of participati... |
26,612 | [Acute coronary syndrome: regional experience of rendering urgent aid at
prehospital stage in Khanty-Mansi Autonomous Okrug--Yugra]. | Aim of the study was assessment of efficacy of rendering urgent aid to patients
with acute coronary syndrome (ACS) at prehospital stage on the territory of
Khanty-Mansi Autonomous Okrug (KhMAO). The analysis showed that yearly about
5000 inhabitants of KhMAO-Yugra received prehospital medical care (30% because
of a... |
26,613 | [Possibilities myocardial biopsy in the diagnosis of myocarditis verification in
patients with idiopathic arrhythmias]. | Aim of the study was to elucidate nosological nature of "idiopathic" arrhythmias
by means of right ventricular endomyocardial biopsy (EMB) and to assess effect
of etiotropic and pathogenetic treatment.
MATERIAL AND METHODS: We included into this study 19 patients (mean age 42.6
+/-11.3 years, 9 women) with atrial fi... |
26,614 | [Evaluation of typical atrial flutter cycle duration during electric stimulation
cardioversion]. | We performed 225 transesophageal electric cardiac stimulation (TEECS) procedures
in order to restore sinus rhythm in patients with atrial flutter (AF) and
ischemic heart disease (IHD) (n = 161) and postmyocarditic cardiosclerosis (n =
64). Mean duration of history of arrhythmia was 7.1 years, mean duration of
prese... |
26,615 | [Prognostic value of the myocardial performance (Tei) index in patients with
chronic heart failure]. | Aim of this study was to define the prognostic value of Tei index compared with
other clinical and instrumental parameters in elderly patients with chronic
heart failure (CHF) observed in outpatient conditions. A total of 97 patients
aged 60 to 85 years with symptoms of CHF NYHA class II--IV due to coronary heart
d... |
26,616 | [Prediction of effectiveness of antihypertensive treatment in patients with
consideration of the role of polymorphisms of angiotensin receptors ATR1]. | PURPOSE: to elucidate the prognostic role of angiotensin receptor (ATR1) gene
polymorphism relative to progression of the disease and effectiveness of
antihypertensive therapy.
MATERIAL AND METHODS: We included in this study 132 consecutive patients (48
women [36.4%, mean age 51.6 years] and 84 men [63.6%, mean age ... |
26,617 | [Factors determining progression of atherosclerosis in extracoronary arteries
after myocardial infarction]. | Aim of the study was to determine association between clinical-anamnestic
factors and degree of progression of atherosclerotic process in magistral
noncocronary arteries during one year after ST-elevation (STE) myocardial
infarction (MI).
MATERIAL: We included into this study 168 men (mean age 59.5 years) with STEMI... |
26,618 | [Assessment of velocity of deformation of abdominal aorta wall with the help of
the multivox working station]. | Most frequent cause of abnormalities of elastic properties of walls of abdominal
aorta is development of atherosclerosis resulting in replacement of elastin by
simpler fibrillar proteins and collagen. This subsequently leads to dilation of
the aorta and formation of aneurism. Increase of collagen content in the aort... |
26,619 | [Cardiac potassium channels: molecular structure, physiology, pathophysiology
and therapeutic implications]. | Potassium channels and currents play essential roles in cardiac repolarization.
Potassium channel blockade by class III antiarrhythmic drugs prolongs cardiac
repolarization and results in termination and prevention of cardiac arrhythmias.
Excessive inhomogeneous repolarization prolongation may lead to electrical
in... |
26,620 | [Multistage endovascular treatment of multifocal atherosclerosis]. | We present a report of a clinical case of multistage endovascular treatment of
multifocal atherosclerosis with involvement of coronary arteries, left renal
artery, and arteries of lower extremities. A 54 year old patient with type 2
diabetes, impaired renal function, vasorenal hypertension, and lowered left
ventric... |
26,621 | [Comparison of characteristics of atherosclerotic plaques in patients with acute
coronary syndrome and stable ischemic heart disease: data of multispiral
computed tomography]. | AIM: To elucidate possibilities of multispiral computed tomography (MSCT) for
assessment of morphology of atherosclerotic plaques in coronary arteries of
patients with acute coronary syndrome (ACS) or stable ischemic heart disease
(SIHD).
MATERIAL AND METHODS: Assessment of internal relief of coronary arteries and
... |
26,622 | [Relationship between warfarin dosing and activity of CYP2C9 assessed by the
content of losartan and its metabolite E-3174 in the urine of patients with
mechanical prosthetic heart valves]. | We evaluated effect of activity of cytochrome P450 CYP2C9 on maintenance doses
of warfarin in 33 patients with implanted artificial heart valves. Losartan test
was used for measurement of concentration of active metabolite E-3174 in urine.
Concentration of E-3174 below 2500 ng/ml in patients with genotype CYP2C981/*... |
26,623 | [Optimization of pharmacotherapy in patients with essential hypertension with
neurohumoral modulators with consideration of data on heart rate variability]. | Long-term treatment of patients with essential hypertension (EH) and autonomic
dysfunction (sympathicotonia type) with lisinopril in combination with
indapamide augmented activity of humoral systems and improved heart rate
variability. Addition of a selective beta-blocker bisoprolol to
lisinopril/indapamide combina... |
26,624 | [Predictive value of cardiopulmonary exercise testing in various categories of
patients with chronic heart value]. | AIM: To specify the prognostic value of parameters of cardiopulmonary exercise
testing (CPET) in patients with chronic heart value (CHF) on optimal medical
treatment depending on gender, age, left ventricular ejection fraction (LVEF),
cardiac rhythm and achievement of target respiratory exchange ratio (RER) > or =
... |
26,625 | [Noncoronary dilated cardiomyopathy after reverse remodeling heart surgery]. | We present here analysis of surgical treatment of 24 patients (5 women, 19 men,
age 20-75, mean age 50.7 +/- 2.5 years) with dilated cardiomyopathy (DCM)
operated during the period from 2008 to 2013. Duration of the disease ranged
from 4 months to 12 years (mean 49.4 +/- 7.5 months). According to symptoms and
resul... |
26,626 | [Treatment of arteril hypertension in patients with chronic kidney disease: a
fixed combination of lercanidipine and enalapril]. | The review of literature presents the basic principles of treatment of arteril
hypertension in patients with chronic kidney disease. The possibilities of
combination therapy with dihydropyridine calcium antagonist lercanidipine and
third-generation ACE inhibitor enalapril. Presented studies showing
nephroprotective... |
26,627 | [Modern conceptions of cardiac amyloidosis]. | Cardiac amyloidosis is accumulation in the heart of a pathologic fibrillar
protein amyloid. It represents a heterogeneous group of states from clinically
insignificant amyloid accumulation in isolated atrial amyloidosis to severe
involvement of the heart in primary amyloidosis when mean duration of life
equals to 6... |
26,628 | [Significance of echocardiography in acute coronary syndrome]. | The paper contains description of possibilities and limitations of ultrasound
diagnosis in patients with acute coronary syndrome (ACS). Main attention is paid
to possibilities of echocardiographic diagnosis of myocardial infarction (MI)
and its complications, as well as to differential diagnostics of ACS and
nonisc... |
26,629 | [Adherence to guidelines on management of acute coronary syndrome in Russian
hospitals and outcomes of hospitalization (data from the RECORD-2 Registry)]. | BACKGROUND: Complete following existing guidelines for management of acute
coronary syndrome (ACS) is known to be associated with better outcomes. Partly
this is explained by lesser adherence to recommendations in high risk patients.
Aim of our study was to assess relationship between degree of following current
gu... |
26,630 | [Effect of intracoronary and intravenous administration of tirofiban loading
dose in patients underwent percutaneous coronary interventions because of acute
coronary syndrome]. | Aim of this multicenter retrospective study was assessment of effect of
intracoronary administration of tirofiban loading dose in troponin positive
patients with acute coronary syndrome (ACS). We analyzed multicenter data base
of patients subjected to percutaneous coronary interventions (PCI) because of
ST-elevatio... |
26,631 | [Factors associated with mitral regurgitation in patients with coronary artery
disease in the absence of myocardial infarction]. | It is known that not only postinfarction left ventricular (LV) remodeling but
also chronic regional myocardial hypoperfusion may cause a compensatory
hypertrophy of undamaged areas of the left ventricle. Can chronic LV
hypoperfusion lead to the development of mitral regurgitation (MR) in CAD
patients without previo... |
26,632 | [24-hour heart rate profile in assessment of target organs in women with
arterial hypertension]. | AIM: To study relationships of 24-hour heart rate (HR) profile with involvement
of the heart and kidney in women with arterial hypertension (AH).
MATERIAL: We examined women (n=273) aged 40-70 years with essential 2-3 degree
AH.
METHODS: Blood pressure (BP) measurements (8 times in a week),
electrocardiography, echo... |
26,633 | [Epicardial adiposity as risk factor of coronary atherosclerosis]. | AIM: To study effect of epicardial adiposity on risk of development and severity
of coronary atherosclerosis.
MATERIAL AND METHODS: We registered classical metabolic risk factors (RF) and
additional factors of cardiovascular risk in 138 men aged 55.47+/-9.07 years
with ischemic heart disease (IHD), functional class ... |
26,634 | [Factors affecting results of coronary bypass surgery in elderly patients]. | Study aim was to compare rates of perioperative complications of coronary bypass
surgery in patients of various age groups and to analyze factors associated with
their appearance. We retrospectively studied 2411 case histories of patients
subjected to coronary artery bypass surgery between January 2006 and December ... |
26,635 | [Arterial hypertension in diabetes mellitus: classical concepts and modern
tendencies]. | Some actual problems of arterial hypertension (AH) in metabolic disturbances and
type 2 diabetes mellitus are considered in this review. Target arterial pressure
levels and principles of correction of AH are specifically analyzed.
Metaanalysis of large studies of efficacy of various groups of antihypertensive
drugs... |
26,636 | [Andersen-Tawil syndrome. Efficacy of class IC drugs]. | A case of a rare disease - Andersen-Tawil the syndrome (ATS) is presented.
Diagnosis of ATS, 7-th molecular-genetic variant of long QT syndrome was made
basing on the characteristic clinical picture (periodic stress induced syncopal
states), data of ECG and its Holter monitoring (pronounced QT prolongation,
bouts o... |
26,637 | [Characteristic of the complement system in patients with ischemic heart disease
with moderate and marked hemolysis after operations with cardiopulmonary
bypass]. | A study of the complement system in cardiosurgical patients with moderate (40
patients) and marked (18 patients) hemolysis after coronary artery bypass
grafting in conditions of cardiopulmonary bypass was carried out. Before and
after operation the content of D35+-, D55+-erythrocytes and reticulocytes in
blood, fre... |
26,638 | [The role of multispiral computed tomography in assessment of viability of the
myocardium and prognostication of left ventricular remodeling in patients with
ST-elevation myocardial infarction]. | Aim of the study was to assess perfusion defect and viability of the myocardium
by the method of multispiral computed tomography (MSCT) in patients with
ST-elevation acute myocardial infarction (AMI) and to assess their prognostic
role in development of remodeling of the left ventricle (LV). We included into
the st... |
26,639 | [Prognosis of hospital mortality in patients with acute decompensation of
chronic heart failure]. | We assessed prognostic value of clinical-laboratory and instrumental parameters
in 100 patients with acute decompensation of chronic heart failure (CHF) in
relation to hospital mortality. Independent predictors of lethal outcome in
patients with acute decompensation of CHF were low systolic arterial pressure at
adm... |
26,640 | [Atrial fibrillation registered for the first time: characteristics of clinical
course, treatment, prognosis]. | To study the clinical presentation of the first episode of atrial fibrillation
(AF), treatment tactics and its compliance with current recommendations,
features of the further clinical course and prognosis in patients with AF we
performed a retrospective study on data of Polyclinic No 1 of the General
Management De... |
26,641 | [Gender related characteristics of clinical status and pharmacotherapy of
patients with paroxysmal and persistent atrial fibrillation]. | Aim of the study was to elucidate gender related characteristics of clinical
status and treatment of patients with atrial fibrillation (AF) hospitalized in a
department of urgent cardiology of multiprofile clinical hospital. In a
retrospective pharmacoepidemiological study we analyzed case histories of 114
men and ... |
26,642 | [Effect of angiotensin converting enzyme lisinopril on the state of vascular bed
in premenopausal women with arterial hypertension]. | We assessed effect of lisinopril on structural-functional state of vascular bed
in 82 premenopausal women with hypoestrogenia and arterial hypertension (AH).
Test with postocclusion reactive hyperemia showed that at the background of
significant lowering of endothelial vasomotor function before treatment 47.5% of
w... |
26,643 | [Spousal concordance of blood pressure levels (results of 17-year follow-up)]. | Study aim was investigation of blood pressure levels (BP) in spouses and
assessment of the role of arterial hypertension (AH) in a spouse as risk factor
(RF) of AH in a 17-years prospective study. Primary study based on a random
sample of citizens of Tomsk (1546 men and women aged 20-59 years) was carried
out in 19... |
26,644 | [Effect of monotherapy with nebivolol, bisoprolol, carvedilol on the state of
vegetative nervous system and sexual function in men with arterial
hypertension]. | Aim of the study was to assess effect of monotherapy with nebivolol, bisoprolol,
carvedilol for 2 months on sexual function in men with arterial hypertension
(AH). Men with 1-2 degree of AH (n=75, age 35-55 years, mean age 48+/-3,5 years)
received monotherapy with these drugs for 2 months. Registration of parameters... |
26,645 | [Mitral regurgitation and coronary stenosis in postmyocardial infarction
patients]. | The results of investigations devoted to relationship of mitral regurgitation
(MR) and scars are contradictive, data on relationship of MR and localization of
coronary lesions are few. Purpose. To determinate relationship of moderate or
severe MR to localization of coronary stenosis in postmyocardial infarction
pat... |
26,646 | [Prediction of severe cardiac complications with the help of myocardial
perfusion scintigraphy in patients with residual chronic total occlusion after
percutaneous coronary interventions]. | Aim of the study was assessment of prognostic value of exercise myocardial
perfusion scintigraphy in patients with stable and unstable angina in whom
revascularization by percutaneous coronary intervention (PCI) was incomplete and
at least one chronic total coronary artery occlusion (CTO) remained after PCI.
Betwee... |
26,647 | [Structure of cardiovascular pathology in pregnant women and efficacy of
regional specialized management]. | From 2000 to 2011 in prospective and retrospective studies we investigated
pregnancy outcomes in all 30417 women treated within framework of the
multidisciplinary management system for pregnant patients with cardiovascular
diseases (hypertension, structural heart disease, aortic pathology and
inflammatory autoimmun... |
26,648 | [A rational approach to the treatment of arterial hypertension in patients with
high cardiovascular risk and metabolic disorders]. | Metabolic disorders are important in the development of cardiovascular diseases.
Experts predict their frequency is steadily rising, which is a serious medical
and social problem in modern society. Arterial hypertension (AH) is the most
common risk factor in patients with metabolic disorders. In the selection of
an... |
26,649 | [Adenosine triphosphate stress 99mTc-MIBI single-photon emission computed
tomography in the diagnosis of ischemic heart disease]. | This review is devoted to possibilities of single-photon emission computed
tomography (SPECT) combined with pharmacological test with adenosine
triphosphate (ATP) to detect myocardial ischemia in patients with ischemic heart
disease (IHD). It contains consideration of contemporary problems and
limitations inherent ... |
26,650 | [First experience of the study "Intramyocardial Multiple Precision
Administration of Mononuclear Bone Marrow Cells in the Treatment of Myocardial
Ischemia"]. | Study aim - to elucidate possibilities of the use of precision administration of
mononuclear bone marrow cells (MBMC) for the treatment of myocardial ischemia
and heart failure. "Intramyocardial Multiple Precision Administration of
Mononuclear Bone Marrow Cells in the Treatment of Myocardial Ischemia" was a
double ... |
26,651 | [Pharmacogenomic control of angiotensin converting enzyme gene I/D polymorphism
predominant risk factor of development of chronic heart failure and target of
enalapril treatment]. | Aim of investigation - to study effect of angiotensin-converting enzyme (ACE)
gene polymorphism as a dominant risk factor of development of chronic heart
failure (CHF) and target for effective therapy with ACE inhibitor enalapril in
patients with ischemic heart disease. We followed 226 patients with CHF on
stable p... |
26,652 | [State of the structure and functions of the arterial wall in patients with
chronic heart failure against the background of permanent atrial fibrillation
and assessment of vasoprotective effect of omega-3 polyunsaturated fatty acids]. | PURPOSE: to evaluate the state of the structure and function of the arterial
wall in patients with chronic heart failure (CHF) of ischemic etiology in
combination with persistent atrial fibrillation (AF) AF and the dynamics of
their changes during therapy with omega-3 polyunsaturated fatty acids (omega-3
PUFA).
MAT... |
26,653 | [Effect of von Willebrand factor and endothelin-1 on formation of thrombotic
status in patients with ischemic heart disease]. | In 44 patients with ischemic heart disease (IHD) and 35 healthy subjects we
studied cascade mechanism of platelets activation by von Willebrand factor
(vWF), and interrelationship of platelet aggregation, level of vWF, and
endothelial dysfunction. The latter was estimated by severity of
vasoconstriction determined ... |
26,654 | [Obstructive sleep apnea syndrome in patients with acute myocardial infarction:
timing of onset of the disease, clinico-functional and some other
characteristics]. | With the aim of elucidating special features of the course of acute myocardial
infarction (MI) in patients with obstructive sleep apnea syndrome (OSA) we
retrospectively studied clinico-functional parameters of 476 patients including
64 (13.3%) who had episodes of apnea during sleep. Frequency of OSA was 1.3
times ... |
26,655 | [The FORTISSIMO program: advantages of fixed full dose combination of
perindopril arginine and indapamide in the treatment of poorly controlled
arterial hypertension]. | In the Russian program FORTISSIMO administration of fixed combination of
perindopril arginine/indapamide (10 mg/2.5 mg) in 2120 patients with poorly
controlled arterial hypertension instead of angiotensin converting enzyme
inhibitors (ACEI) or -receptor antagonists (ARB) with hydrochlorothiazide given
separately or... |
26,656 | [Electrocardiographic predictors of response to cardiac resynchronization
therapy of heart failure in patients with dilated cardiomyopathy]. | The aim of our study was to identify electrocardiographic predictors of response
to cardiac resynchronization therapy (CRT) in patients with dilated
cardiomyopathy (DCM).
METHODS: 46 patients with DCM (76% men; mean age 48.8+/-12 years; mean NYHA
class 3.09+/-0.3; mean QRS duration 167+/-30.1 ms; left ventricular ej... |
26,657 | [Interrelationship between polymorphic markers of methylenetetrahydrofolate
reductase gene and development of acute disturbance of brain circulation in
families of patients with atrial fibrillation]. | In the present work we for the first time on the clinic-genetic material
revealed genetic predictors of development of acute disturbance of brain
circulation (ADBC) in families of patients with atrial fibrillation (AF) namely
polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene. Genotype
CC was sign... |
26,658 | [Clinical role of lipoprotein-associated phospholipase A2]. | Inflammation plays an important role in origin and progression of atheromatous
plaque. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a
biomarker of inflammation and a predictor of vascular events. Lp-PLA2 is an
enzyme secreted by leukocytes and associated with circulating lipoproteins and
macropha... |
26,659 | [Mechanisms of development of thromboembolic complications in patients with
atrial fibrillation]. | Thomboembolism is the most threatening complication in patients with atrial
fibrillation. Main source of embolism is the left atrial thrombosis. Mechanisms
of development of thromboembolic complications in patients with arrhythmias are
far from being deciphered. In this review we discuss possible mechanisms of
form... |
26,660 | [Cardiac resynchronizing therapy. Selection of patients and their management
after implantation of biventricular heart pacemaker]. | Chronic heart failure (CHF) - a widely spread manifestation of various forms of
heart diseases - is characterized by high mortality. Prognosis is especially
unfavorable in patients with wide QRS complex. Method of resynchronizing therapy
was elaborated for the treatment of this group of patients in addition of
medi... |
26,661 | [Bleeding in the appointment of dabigatran in the patients with renal
insufficiency caused by coadministration of spironolactone and ACE inhibitors]. | It is a case report of bleeding when using dabigatran in patient with renal
failure caused by the concurrent use of spironolactone and
angiotensin-converting enzyme (ACE) inhibitors. The patient (75 years old) at
the decompensation of chronic heart failure in the background of persistent
atrial fibrillation was app... |
26,662 | [Efficacy of reperfusion therapy in syndrome of predominant right ventricular
dysfunction associated with inferior myocardial infarction]. | Aim of the study was choice of optimal tactics of treatment of patients with
syndrome of predominant right ventricular (RV) dysfunction, associated with
inferior myocardial infarction. We compared immediate and remote results of 3
strategies of treatment of 100 patients admitted to N.V. Sklifosovsky Research
Instit... |
26,663 | [Multifocal atherosclerosis as a factor of unfavorable prognosis in patients
with ST elevation myocardial infarction and type 2 diabetes mellitus]. | Multifocal atherosclerosis (MFA) and diabetes mellitus (DM) determine less
favorable course of acute vascular catastrophes. We analyzed dependence of one
year prognosis of patients with myocardial infarction (MI) with and without DM
on the presence of multifocal atherosclerosis. The analysis showed that number
of c... |
26,664 | [Effect of perindopril on the processes of subclinical inflammation in patients
with arterial hypertension and type 2 diabetes mellitus]. | We conducted comparative analysis of treatment 52 patients (7 men and 45 women
aged 42-64 years, mean age 51.1 years) with I-II degree arterial hypertension
(AH) and type 2 diabetes mellitus with the use of angiotensin converting enzyme
inhibitor perindopril and with of other drugs. During 6 months effective control... |
26,665 | [Comparison of morphological features of carotid arteries atherosclerotic
plaques with clinical-instrumental data in symptomatic and asymptomatic patients
with severe carotid atherosclerosis]. | A complex histomorphometric and clinical-instrumental analysis of
atherosclerotic lesions of the carotid arteries obtained during carotid
endarterectomies (CEE) of patients with hemodynamically significant stenoses was
conducted. Two groups of patients were compared: symptomatic, which earlier
underwent cerebral va... |
26,666 | [Peculiarities of the course of arterial hypertension in patients with
atherosclerotic stenoses of brachiocephalic arteries before and after surgery on
carotid arteries]. | Study aim was to investigate relationship between atherosclerosis of carotid
arteries (CA) and the presence of arterial hypertension (AH) and possibilities
of correction of AH after surgery. We examined 70 patients with episodes of
elevation of arterial pressure (AP) scheduled for surgical interventions on
brachioc... |
26,667 | [Diurnal blood pressure profiles in night shift workers with incipient changes
of blood pressure level]. | Aim. To study diurnal blood pressure profiles (DBPP) during work in different
time of the day including nocturnal hours in persons with initial stages of
blood pressure (BP) increase or decrease. Material and methods. The study cohort
consisted of 995 locomotive drivers (46682 BP measurements) divided into groups
w... |
26,668 | [Primary and secondary prevention of cardio-vascular diseases: main directions
of a national multicenter study in Tajikistan]. | Data on goals and tasks of the prospective national study of detection of risk
factors as well as of realization of primary and secondary prevention of
ischemic heart disease in the Republic Tajikistan are presented in this paper.
According to protocol the study has two stages. Stage 1 is a single step (cross
secti... |
26,669 | [Protective action of ethylglutathione at hypoxia-reoxygenation of the heart:
role of glucose]. | Glutathione is the main redox buffer in cardiomyocytes. The action of
ethylglutathione possessing antioxidant properties on functional disorders
evoked by 30-minute hypoxia of the isolated rat heart with subsequent
reoxygenation has been studied. In control experiments, the presence of glucose
(11 mM) in hypoxic pe... |
26,670 | [An association of the 825 polymorphism of the g protein 3 subunit with obesity
in Kyrgyz population]. | GOAL: To study an association of G protein (GP) 3 subunit 825 polymorphism with
obesity in native Kyrgyzes.
MATERIAL AND METHODS: 210 persons: 89 patients (female - 35, male - 54) with
obesity (body mass index [BMI] more or equal 30 kg/m2) and 121 apparently
healthy controls (38 female, 83 male) with normal BMI. Art... |
26,671 | [Myocardial revascularization before abdominal aortic surgery in patients with
ischemic heart disease]. | We retrospectively analyzed 2 cohorts of patients treated in two clinics
implementing different strategies of preoperative examination and lowering of
perioperative cardiac risk. Patients in clinic 1 (group I, n=86, mean age
59.4+/-7.7 years) were subjected to coronary angiography (CAG) and if indicated
- to preven... |
26,672 | [The rational approach to the estimation of the myocardial infarction size]. | The paper contains review of published data on various methods of quantitative
assessment of myocardial infarction (MI) with demonstration of their advantages
and drawbacks. Comparative analysis of applicability of existing biochemical
markers of necrosis for measurement of the volume of myocardial damage is also
p... |
26,673 | [The place of lercanidipine in the treatment of cardiovascular diseases]. | The data are presented on using the first, second and third generation calcium
antagonists in cardio-vascular pathology patients. The accent has been made on
the improved pharmacokinetic profile of the third generation calcium antagonists
where modern preparation lerkanidipin belongs to. It is shown that lerkanidipi... |
26,674 | [Endovascular closure of the left atrial appendage in patients with atrial
fibrillation: review of modern data and own experience of application]. | Atrial fibrillation (AF) is the most often disturbance of cardiac rhythm met in
clinical practice. Long term therapy with anticoagulants is used for prevention
of thrombi formation in left atrial appendage and consequent thromboembolism.
However some patients have contraindications to this therapy. This article
con... |
26,675 | [Hypertrophic cardiomyopathy -- modern state of the problem. Issues of
epidemiology and nomenclature, genetics and pathophysiology, variants of course
and differential diagnosis]. | The problem of the study of hypertrophic cardiomyopathy (HCM) has preserved its
actuality because of high prevalence (1:500), risk of sudden cardiac death (SCD)
in individuals of young able-bodied age. Subject of great interest appear
problems of search for additional clinical, instrumental and genetic markers,
env... |
26,676 | [Structural and functional status of arteries in young and middle-aged men with
ischemic heart disease]. | Aim of the study was to determine whether structural and functional status of
arteries differ between young and middle-aged men with ischemic heart disease
(IHD). A total of 78 men aged 28 to 50 years were recruited in this study: 49
with angiographically proven obstructive atherosclerosis of coronary arteries,
29 ... |
26,677 | [An experience of the use of a curative method of cardiac shock wave therapy in
patients with ischemic heart disease]. | Aim of the study was to assess effects of cardiac shock wave therapy (CSWT) in
patients with coronary artery disease (CAD) with refractory stable angina
pectoris. Seventeen CAD patients with refractory II-IV class angina (3 women and
14 men, mean age 67.4+/-8.6 years) received the course of 9 procedures of CSWT.
Al... |
26,678 | [Clinical characteristics of patients and number of stem cells in the myocardium
of right atrial appendage in patients with ischemic heart disease]. | In the last years stem cells (SC) have been identified in rodent and human
hearts. These cells have ability to multilineage differentiation in vitro and in
vivo and improve cardiac function. The development of new methods of isolation
SC offers new approaches to cardiac regeneration. However, the question of how
in... |
26,679 | [Comparative study of results of coronary angiography in patients with first and
repetitive myocardial infarction]. | We compared coronary angiography data from 65 patients with first myocardial
infarction (fMI) and 65 patients with repetitive MI (reMI). Coronary
angiographic status in both patients with fMI and reMI was characterized by
predominance of multivessel lesions with stenoses localized in branches of both
coronary arter... |
26,680 | [The multifactorial genesis of left ventricle remodeling in patients with
essential arterial hypertension]. | We examined 122 patients (70 men and 52 women, mean age 56.17+/-1.4 years) with
essential hypertension (EH) by echocardiography, radionuclide and radioimmune
methods. In 43 patients carotid-femoral pulse wave velocity (PWV) was evaluated
by means of the Complier method. In patients with stage I EH cardiac index was ... |
26,681 | [Cardiac resynchronization therapy in patients with permanent atrial
fibrillation]. | In our study we compared effect of cardiac resynchronization therapy (CRT) in
chronic heart failure (CHF) patients with permanent atrial fibrillation (AF) and
patients with sinus rhythm. Special feature of our work was that patients with
permanent atrial fibrillation didnt have obligatory ablation of
atrio-ventricu... |
26,682 | [Ischemic heart disease complicated by heart failure: possibilities of surgical
treatment]. | Aim of the study was to assess remote results of surgical reconstruction of the
left ventricle (LV) in patients with ischemic heart disease (IHD) and chronic
heart failure (CHF). During 1996-2010 136 patients with IHD complicated by CHD
were subjected to surgery. The patients were divided into 2 groups: with LV
ane... |
26,683 | [Antioxidant properties of apelin-12 and its structural analogue in experimental
ischemia and reperfusion]. | Effects of apelin-12 H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH (A12)
and its modified analogue
H-(NMe)Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-OH (I) on activity of
antioxidant enzymes, formation of malonic dialdehyde (MDA) and generation of
reactive oxygen species (ROS) were studied in ex vivo an... |
26,684 | [Nicorandil in the treatment of patients with ischemic heart disease]. | Adequate drug therapy of stable ischemic heart disease directed at reduction and
prevention of main clinical symptoms of the disease, increase of exercise
tolerance to physical effort, improvement of quality of life and prognosis
remains an actual problem. Nicorandil combines properties of an antianginal drug
and c... |
26,685 | [LINKOR: results of observational program in patients with myocardial
infarction]. | The results of Assessment Program effective treatment of patients with
myocardiaL INfarction drug ProCORalan (ivabradine) in outpatient practice,
conducted in 53 cities of the Russian Federation, 333 doctors. Included 1226
patients (822 men and 404 women, average age 60,1+/-9,3 years). Despite
treatment, before inc... |
26,686 | [Long-term results of radiofrequency catheter ablation of long-lasting
persistent atrial fibrillation: five years of follow-up]. | AIM: To evaluate long-term results of radiofrequency catheter ablation (RFA) vs.
rate-control strategy in patients with long-lasting persistent atrial
fibrillation (AF) METHODS: We assessed 5-years results in 66 patients
(53.3+/-12.3 years old, 8 women) with long-lasting persistent AF who underwent
RFA (ablation gr... |
26,687 | [Genetic predictors of sick sinus node syndrome]. | The article is devoted to the role of heredity in development of the sick sinus
node syndrome (SSNS). We have examined 14 probands and 110 their relatives from
families with idiopathic SSNS and established the role in development of
hereditary SSNS of polymorphisms of the following genes: -2-adrenoreceptor,
enzyme ... |
26,688 | [The role of matrix metalloproteinases in assessment of prognosis in patients
with ST-elevation myocardial infarction during hospital stay]. | Aim of the study was to investigate role of matrix metalloproteinases (MMP) in
assessment of prognosis of repetitive cardiovascular events during hospital stay
of patients with ST-elevation (STE) myocardial infarction (MI). We consecutively
included into this study 175 patients with diagnosis of STEMI. Content of MM... |
26,689 | [Cardiorespiratory abnormalities and cerebral oxygen supply in chronic
thromboembolic pulmonary hypertension]. | Aim of the study was assessment of severity of cardiorespiratory abnormalities
and cerebral oxygen supply in patients with chronic thromboembolic pulmonary
hypertension (CTEPH). We examined 56 patients with diagnosis of chronic
pulmonary thromboembolism and duration of the disease 3 (1.5-4.1) years.
According to da... |
26,690 | [Prognostic role of C-reactive protein in progression of atherosclerosis in a
year after coronary bypass surgery]. | Aim of the study was to assess prognostic role of high sensitivity C-reactive
protein (CRP) in progression of atherosclerosis in patients with ischemic heart
disease (IHD) in a year after coronary artery bypass grafting (CABG). We
examined 49 patients with stable IHD subjected to elective CABG (45 with and 4
withou... |
26,691 | [Inhospital thrombolism of right cardiac chambers]. | Veins of lower extremities are classic sources of pulmonary artery
thromboembolism (PATE). But one should not underestimate presence of thrombi in
other potential sources - veins of small pelvis, superior vena cava, and
chambers of the heart. We analyzed 652 case histories and autopsy data of
patients in whom PATE ... |
26,692 | [Osteoporosis and arterial stiffness: study of 103 women with mild to moderate
risk of cardiovascular disease]. | OBJECTIVE: to evaluate the relationship between arterial stiffness and bone
metabolism in women with mild to moderate risk of cardiovascular disease (CVD).
METHODS: In 103 postmenopausal women (mean age 57.0 years, 95% CI 50.0-64.0)
with mild to moderate risk of CVD (SCORE<5), no more than mild hypertension,
normal ... |
26,693 | [Hypertensive crisis: pathogenesis, clinic, treatment]. | Contemporary data on mechanisms of development, types, and clinical picture of
hypertensive crisis (HC) are presented. Algorithms of rational therapy of
uncomplicated and complicated HC are considered. Appropriateness of the use in
HC of antihypertensive drugs with multifactorial action is stressed. These drugs
inc... |
26,694 | [Clinical significance of filiform structures (Lambls excrescences) on cusps of
cardiac valves]. | This literature review is devoted to clinical significance of filiform
structures (Lambls excrescences) which can be revealed on cusps of cardiac
valves by transesophageal echocardiography. The review contains analysis of
frequency of detection of these structures at pathomorphological investigation
and transesopha... |
26,695 | [Chronic heart failure and osteoporosis]. | Osteoporosis (OP) and chronic heart failure (CHF) are chronic noninfection
diseases which are characterized not only by high prevalence but also by
development of severe complications such as fractures in OP and decompensation
in CHF. These complications lead to loss of functional, social activity and
independent w... |
26,696 | [Genetic predictors of myocardial infarction in subjects of young age]. | to investigate associations of single nucleotide polymorphisms (SNP) rs499818
(6p24.1), rs619203 of ROS1 gene (6q22), rs10757278 rs1333049 (9p21.3), rs2549513
(16q23.1), rs4804611 of ZNF627 gene (19p13.2) with myocardial infarction in
subjects of young age. The group of patients with MI (n=99) aged less than 45
yea... |
26,697 | [Optimal timing of the second stage of revascularization in the treatment of
patients with ST-elevation myocardial infarction and multivascular involvement]. | An assessment of outcomes in 187 patients with ST elevation myocardial
infarction (STEMI) with multivessel coronary disease who underwent primary
percutaneous coronary intervention (PCI) was done. All patients were divided
into two groups: in group 1 (n=39) second phase of revasculrization was
performed within 60 d... |
26,698 | [Achievement of goal resting heart rate in patients with stable angina and
hypertension at the background of therapy with -adrenoblockers in real clinical
practice]. | β-Adrenoblockers improve quality of life and in a number of cases life prognosis
in patients with stable angina (SA). Dose of -adrenoblockers is considered
optimal if at the background of treatment resting heart rate (rHR) is
persistently decreased down to 55-60 bpm. But according to data of international
registrie... |
26,699 | [Vasomotor endothelial dysfunction in young men with grade 1 arterial
hypertension]. | In order to study vasomotor endothelial function and risk factors of endothelial
dysfunction in young men with grade 1 arterial hypertension (G1AH) we examined
76 men with G1AH and 30 healthy men aged 20-40 years. Flow-mediated
vasodilatation (FMD) of the brachial artery was assessed by ultrasonic method of
Celerma... |
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