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27,000 | [Thiotriazoline in the Treatment of Stable Angina Pectoris of II-III Functional
Class]. | Trimetazidine is a metabolic agent of proven efficacy in improving myocardial
ischemia and angina. A comparative international multicenter randomized trial,
assessed anti-anginal anti ischemic efficacy and safety of Trimetazidine (60
mg/d) and Thiotriazoline (600 mg/d) in symptomatic patients with chronic
ischemic ... |
27,001 | [Effects of Meldonium in Early Postmyocardial Infarction Period]. | The aim of PMICS (Postmyocardial Infarction Cardiosclerosis) patients therapy
within the dispensary supervision is CCI (Chronic Cardio Insufficiency)
progression prevention, life quality improvement, hospitalization number
decrease and life prognosis improvement. Despite the developed approaches to the
given patien... |
27,002 | [Cardio-Nephroprotection--the Most Important Goal of Antihypertensive Therapy in
Patients With Type 2 Diabetes]. | AIM: to study the opportunities for cardio and nephroprotection by 6-month
combined antihypertensive therapy with lisinopril and amlodipine in hypertensive
patients with diabetes mellitus (DM) type 2.
MATERIALS AND METHODS: 30 patients with arterial hypertension (AH) stage II-III,
chronic kidney disease (CKD) stages... |
27,003 | [31P Magnetic Resonance Spectroscopy in Patients With Various Genesis of Left
Ventricular Hypertrophy]. | PURPOSE: to assess status of myocardial energy metabolism in patients with
different etiology of left ventricular hypertrophy by phosphorus magnetic
resonance spectroscopy (MRS) compared with healthy individuals.
METHODS: The study included 94 people: 30 healthy volunteers (group 1), 35
patients with arterial hypert... |
27,004 | [Efficiency of Pulmonary Ventilation in Remote Period After Surgery in Patients
With Chronic Pulmonary Thromboembolism]. | AIM: to assess efficiency of pulmonary ventilation in remote period after
surgical treatment of chronic pulmonary thromboembolism (CPTE).
MATERIAL AND METHODS: We examined 29 patients with CPTE with median age 49
(38-60) years. Pulmonary ventilation was studied by body plethysmography and its
efficiency was evaluate... |
27,005 | [Paradox of Obesity and Cardiovascular Mortality]. | Obesity is known as an independent risk factor of a number of chronic
noninfectious disorders, however some investigations testify to the presence of
"obesity paradox". The aim of the present review was to analyze results of
investigations purposed to assess the effect of an elevated body mass index
(BMI) and obesi... |
27,006 | [Twenty Years' Experience of the Surgical Treatment of Giant Ascending Aortic
Aneurysms]. | Giant ascending aortic aneurysm is one of the worst lesions of the
cardiovascular system. Timely surgical treatment provides the only chance to
prolong the lives of such patients. Life expectancy without surgery in these
patients is minimal; they die from a ruptured aneurysm or decompensation of
organs and systems.... |
27,007 | [Analysis of the Effectiveness of Renoprotection of Low-Protein Diet and
Ketoanalogues of Amino Acids In Patients With Chronic Kidney Disease]. | AIM: Analysis of the effectiveness of renoprotection in patients with chronic
kidney disease (CKD), who is observed by general practitioners for up to 72.1
months, keeping traditional LPD or LPD with prescription of ketoanalogues of
amino acids (KA/AK).
METHODS: 63 patients with CKD stages 3-4, mainly with glomerulo... |
27,008 | [Therapeutic Angiogenesis Using Growth Factors: Current State and Prospects for
Development]. | Therapeutic angiogenesis has been in use for treatment of ischemic diseases for
about 15 years. During this period of successes and failures this field has
accumulated a significant amount of published and ongoing surveys giving
insights and raising new questions and problems. One of the most utilized
methods for t... |
27,009 | [Methods of Prevention of Sudden Death in Chronic Heart Failure]. | Chronic heart failure (CHF) is a natural finale of all cardiovascular diseases.
Its prevalence in Russian Federation (as assessed using traditional Framingham
criteria) is 4.5% what corresponds to 5 million patients. Prognosis of
decompensation of cardiac action remains unfavorable even at the background of
optimal... |
27,010 | [Isolated Systolic Hypertension in Different Ages]. | Hypertension is the leading risk-factor for cardiovascular disease and death
from them. Traditionally, the problem of isolated systolic hypertension is
associated with old age in mind the natural dynamics of systolic and diastolic
blood pressure throughout life. Isolated systolic hypertension is the most
common typ... |
27,011 | [Methods of Assessment of the Right Ventricular Function]. | The review contains contemporary data of assessment on right ventricular (RV)
function by various instrumental methods of investigation. Among all these
methods multispiral computed tomography (MSCT) appears to be most perspective.
Accuracy and reproducibility of measurements of RV function by MSCT and
comparable w... |
27,012 | [Endocardial Electrophysiological Study in an Asymptomatic Competitive Athlete
With Ventricular Preexitation due to Conduction via Fasciculoventricular
Accessory Pathway]. | We present a clinical case of a rare form of the WPW phenomenon due to
anterograde conduction over fasciculoventricular accessory pathway in
20-year-old competitive athlete. The patient had no history of palpitations or
syncope. ECG revealed shortening of PQ interval (112 ms) and wide QRS complex
due to conduction ... |
27,013 | [Carriage of A Allele of Polymorphic Marker G(-238)A of TNF Gene Is Associated
With Unfavorable Prognosis in Patients With Chronic Systolic Heart Failure]. | AIM: to elucidate association between polymorphic markers of interleukin-6
(Il-6) and tumor necrosis factor (TNF) genes and unfavorable outcomes in
patients with chronic heart failure (CHF).
MATERIAL AND METHODS: We determined levels of TNF and Il-6 and genotypes of
polymorphic markers G(-238)A of TNF gene (rs361525... |
27,014 | [In-hospital and remote results of the use of sirolimus coated coronary stent
CYPHER]. | Stents were implanted to 554 previously non-revascularized patients in 703
injured coronary segments; 32% of stented stenoses were complicated; 23% of
patients received 2-4 stents. Immediate success was 100% with no cases of acute
stent thrombosis. Rate of in-hospital subacute thrombosis and non-Q-wave
myocardial i... |
27,015 | [Dynamics of prevalence of ischemic heart disease and risk of cardiovascular
death in open population of Tiumen]. | Prevalence of ischemic heart disease (IHD) has been repeatedly studied in 3 sex
and age stratified representative samples of Tyumen citizens. Prevalence of IHD
in Tyumen open population is 11.7 among men and 13.2% among women. Prevalence of
definite IHD is 7.1 and 8.4%, respectively. Studies conducted with 5 years
... |
27,016 | [Prognostic value of C-reactive protein and neopterin in autologous bone marrow
cells transplantation]. | Relationship between levels of C-reactive protein (CRP) and neopterin and
changes of left ventricular function was studied in 23 patients with heart
failure (mean age 48.5+/-11.5 years) subjected to transplantation of autologous
bone marrow cells (TABMC). Cells were administered intracoronary irrespective of
corona... |
27,017 | [Effect of 6-month therapy with simvastatin on lipid transport function of the
blood and the state of endothelium in patients with diabetes and hypertension]. | The state of lipid transport function of the blood, blood contents of stable
nitrogen metabolites, and proinflammatory cytokines (TNF-a and IL-1b) during
therapy with simvastatin were studied in 29 patients receiving combination
antihypertensive therapy with angiotensin converting enzyme inhibitors (ACEI)
and verap... |
27,018 | [Noninvasive diagnosis of the state of lower extremities arterial vascular bed
in patients with diabetes of type 2]. | Complex noninvasive investigation of arterial vascular bed and microcirculation
of lower extremities was carried out in 87 patients with diabetes and 47
patients with atherosclerosis obliterans of lower extremities without diabetes.
Color duplex scanning allowed to detect occlusive-stenotic and nonocclusive
changes... |
27,019 | [Prognostic significance of parameters of heart rate variability as a risk
factor of development of hypertension]. | Risk factors and parameters of heart rate variability during active
orthoclinostatic test in subjects with normal blood pressure were assessed in a
5 year cohort study on 519 individuals. Logistic stepwise regression revealed
most informative factors associated with development of hypertension: sex
(p=0.029), body ... |
27,020 | [Comparative efficacy and safety of contemporary Angiotensin converting enzyme
inhibitors moexipril and spirapril in women with postmenopausal metabolic
syndrome]. | Moexipril (7.4-15 mg/day) was given to 34, spirapril (3-6 mg/day) -- to 18
postmenopausal women with hypertension and metabolic syndrome for 16 weeks.
Hydrochlorthiazide was added when therapy was not sufficiently effective. Both
angiotensin converting enzyme inhibitors had similar hypotensive activity: blood
press... |
27,021 | [Brain natriuretic peptide as marker and factor of prognosis in chronic heart
failure]. | The role of natriuretic peptides in pathogenesis of chronic heart failure (CHF)
is reviewed. Main attention is given to significance of measurement of brain
natriuretic peptide in the following clinical situations related to CHF:
diagnosis of CHF, screening of patients with symptomless left ventricular
dysfunction,... |
27,022 | [Chronic fatigue syndrome in cardiology neurohumoral changes]. | Chronic fatigue markedly worsens quality of life of cardiological patients.
Chronic fatigue and chronic fatigue syndrome are neuro-immuno-endocrine
disorders which manifest as moderate and severe even invalidizing fatigue with
psychosomatic symptoms. External and internal stress such as psychological
stress, stress... |
27,023 | [Restenosis after bare-metal stents implantation in small coronary arteries.]. | Potential of bare uncoated metal stents in prevention of restenosis in coronary
arteries with diameter of 2.2-3.0 mm in comparison with balloon angioplasty (BA)
was studied in 426 patients with ischemic heart disease (mean age 58+/-11 years,
16% women, 8% with diabetes, total cholesterol 211+/-44 mg/dl, all received... |
27,024 | [Trimetazidine in complex therapy of acute myocardial infarction at the
background of diabetes mellitus type 2.]. | Patients (n=52) with acute myocardial infarction (MI) and diabetes mellitus type
2 older than 18 years were distributed within first 24 hours of MI into 2
groups. In patients of group 1 (n=28) standard therapy was supplemented with
trimetazidine (70 mg/day) for 30 days, patients of group 2 received only
standard th... |
27,025 | [Assesment of Parameters of QT Interval in Children and Adolescents.]. | Aim. To determine limits of interval QT in children and adolescents aged 0-17
years and to detect possible ethnic differences of its changes. Material and
Method. Twelve lead ECGs were recorded in 1531 subjects without overt
cardiovascular pathology (47.2% females, 52.8 males, 57.3% of Slavic and 42.7%
of Buryat i.... |
27,026 | [Electrical instability of the myocardium in patients with acquired heart
defects.]. | Aim of the study was to investigate electrophysiological state of the myocardium
and conduct comparative analysis of informative power of methods of dipole
electrocardiography and signal averaged ECG with detection of late ventricular
potentials for prognostication of ventricular heart rhythm disturbances in
patien... |
27,027 | [Influence of long-term therapy with enalapril on late postinfarction remodeling
and functional state of the left ventricle in patients with diastolic heart
failure.]. | Enalapril (average dose 7,0+/-0.8 mg) was given for 12 weeks to 15 patients with
preserved left ventricular (LV) systolic function who had survived large focal
myocardial infarction small i, Ukrainian6 months before that. The use of
enalapril was associated with 49% lessening of severity of clinical signs of
heart ... |
27,028 | [Polymorphism of genes of factors of hemostasis in patients with early
development of ischemic heart disease.]. | The review is devoted to analysis of data, related to contribution of genetic
peculiarities of the hemostasis system to early development of ischemic heart
disease (IHD). Information is presented on polymorphisms of tissue factor,
coagulation factors VII, V, prothrombin, thrombomodulin, fibrinogen, thrombin
activat... |
27,029 | [Rehabilitation of patients with ischemic heart disease at outpatient stage.]. | The article is assigned to general practitioners and devoted to the outpatient
combined rehabilitation of coronary heart disease patients, including those
after myocardial infarction. In the part concerning the physical rehabilitation
there is given the classification of patients by functional classes, the
exercise... |
27,030 | [Comparative analysis of efficacy of endovascular interventions in native
vascular bed and grafts in patients with ischemic heart disease after coronary
artery bypass surgery]. | AIM: Investigation of efficacy of endovascular interventions in native vascular
bed and grafts, elucidation of factors, affecting immediate and remote prognosis
after endovascular treatment. MATERIAL AND METHODS Coronary stenting was carried
out in 212 patients who had previously undergone coronary bypass surgery. S... |
27,031 | [Activity of angiotensin converting enzyme in blood serum of patients with
stable effort angina]. | AIM: To study activity of angiotensin converting enzyme (ACE) in blood serum of
patients with stable effort angina.
MATERIAL AND METHODS: ACE activity was measured in 11 patients (age 35-45, mean
46.5+/-1.6 years) with typical class II-III effort angina without hypertension
or contractile insufficiency of the myocar... |
27,032 | [Spectral parameters of heart rate variability and frequency of detection of
autoantibodies to beta(1)-adrenoreceptors in patients with tachyarrhythmias:
idiopathic and at the background of primary myocardial diseases]. | In order to assess parameters of heart rate variability (HRV) and prevalence of
autoantibodies against the beta(1)-adrenoreceptors in patients with cardiac
arrhythmias we studied 42 patients with arrhythmias and 20 healthy control
subjects. Thirty one patients with idiopathic arrhythmias were included in group
I: w... |
27,033 | [Complex analysis of risk factors of hypertension in subjects involved in
managerial activity]. | We performed complex analysis of genetic and nongenetic factors facilitating
development of arterial hypertension in subjects involved in managerial activity
and revealed peculiarities of dermatoglyphic phenotype of susceptibility to this
type of pathology. By means of methods of pattern recognition we assessed powe... |
27,034 | [Clinical value of detection of insulin resistance in woman with metabolic
syndrome]. | Hyperinsulinemic and euglycemic clamp studies were done in 17 women selected
from 64 postmenopausal female patients aged 46-67 years with clinical picture of
metabolic syndrome, and in 7 control women. Clamp test made it possible to
follow dynamics of insulin and other hormones in the process of regulation of
gluco... |
27,035 | [Hyperhomocysteinemia in men of Novosibirsk]. | Prevalence of hyperhomocysteinemia (HHC) in a sample of male population (n=84,
age 50-64 year) of Novosibirsk assessed in the framework of the international
project "Determinants of cardio-vascular diseases in the Eastern Europe:
multicentral cohort research" during winter-spring period of vitamin deficiency
was 50... |
27,036 | [Controlled reperfusion improves the metabolic and functional recovery of the
isolated heart in rats after total ischemia]. | Metabolic and functional effects of a hypocalcium reperfusion solution (RS) with
low oxygen content containing d-glucose, trisamine, d-mannitol and I-aspartic
acid have been studied in isolated rat hearts. The hearts were initially
perfused for 20 min with the Krebs solution under constant left atrial filling
press... |
27,037 | [Reversible inhibitory action of adenosine diphosphate ribose on isolated rat
heart and rat heart in vivo]. | Cardiotropic effects of endogenous regulator of intracellular ionic balance
adenosine diphosphate ribose (ADP-ribose) was studied on isolated rat heart
using standard retrograde perfusion and on rat heart in vivo by means of
implanted arterial catheters. Parameters registered were heart rate, pressure
developed in ... |
27,038 | [Disturbances of thyroid function after coronary angiography]. | Frequency of thyroid gland functional disturbances after introduction of
iodine-containing radiographic contrast agents during coronary angiography was
studied in 146 patients, residents of the zone of borderline iodine deficit.
Frequency of thyroid pathology was high at baseline (39%). Functional state of
the thyr... |
27,039 | [Contemporary approaches to the treatment of arterial hypertension and ischemic
heart disease]. | Prognostic advantage of a combination of calcium antagonist and angiotensin
converting inhibitor (ACEI) over combination of beta-adrenoblocker with thiazide
diuretic was proved in a large randomized study of long term treatment of
arterial hypertension. In another randomized study administration of ACEI for 12
mont... |
27,040 | [Current views about the role of purin metabolism disorders in patients with
arterial hypertension and losartan potentialities]. | The analysis of correlation between cardiovascular diseases and hyperuricaemia
as a component of methabolic syndrome has been performed; the emphasis has been
done on predominant mechanism of its development -- reduction of renal
clearance. The need for primary prophylaxis of stroke with a help of safe
metabolicall... |
27,041 | [Contemporary approaches to the treatment of chronic heart failure in adults
(after materials of recommendations of American College of Cardiology and
American Heart Association, 2005)]. | Detailed and critical analysis of a novel version of the "Updated Guideline for
the Diagnosis and Management of Chronic Heart Failure (CHF) in the Adult"
prepared by experts of American College of Cardiology and American Heart
Association is given. The novel version contains somewhat modified
recommendations on the... |
27,042 | [Immediate and remote results of stenting of left coronary artery trunk in
patients with ischemic heart disease]. | The aim of this investigation was assessment of efficacy of stenting in patients
with ischemic heart disease with lesions of left coronary artery (LCA) trunk. In
the A.N. Bakulev Scientific Center of Cardiovascular Surgery between June 1997
and March 2005 stenting of LCA trunk was carried out in 50 patients (33 with... |
27,043 | [Causes and outcomes of coronary arteries perforations]. | Coronary artery perforation is a rare but serious complication of percutaneous
coronary interventions. Aim of this study--to assess inhospital and long term
outcomes in patients in whom perforation occurred during coronary intervention
and elucidation of predictors of coronary artery perforation. Between May 1997
a... |
27,044 | [Cytoarchitectonics and parameters of aggregation of erythrocytes in patients
with acute myocardial infarction]. | AIM: To assess cytoarchitectonics and parameters of aggregation of erythrocytes
in patients with acute myocardial infarction, to elucidate their relationships
with risk factors of ischemic heart disease.
MATERIAL AND METHODS: We examined 80 patients with acute myocardial infarction,
20 patients with stable angina pe... |
27,045 | [Effect of twelve-month combined therapy with perindopril and indapamide on the
level of blood pressure and left ventricular hypertrophy in patients with
hypertensive disease]. | Left ventricular hypertrophy (LVH) in patients with hypertensive disease is
associated with unfavorable prognosis. Long term and effective antihypertensive
therapy is capable to cause reverse development of LVH. We included in this
study 72 patients (27 men, 45 women, age from 34 to 72 years) with untreated 1st
and... |
27,046 | [Advantages of long-term controlled stepwise therapy of arterial hypertension
with the use of angiotensin converting enzyme inhibitor spirapril]. | AIM: Achievement of long-term effective control of blood pressure (BP) in
patients suffering from arterial hypertension by means of elaboration of stage
by stage program of antihypertensive therapy and proof of its advantage over
prescription of hypotensive drugs in real clinical practice.
MATERIAL AND METHODS: Effe... |
27,047 | [Levels of fatty acid binding protein before and after direct current
cardioversion of atrial fibrillation or flutter in patients without acute
coronary syndrome]. | It is not known whether FABP suggested as an early marker of myocardial necrosis
increases after direct current cardioversion (DCC). Moreover there are no data
on FABP levels in patients with atrial fibrillation (AF) and flutter.
AIM: To find out whether DCC induces acute changes of FABP levels in patients
with AF o... |
27,048 | [Glycoprotein IIb/IIIa antagonist eptifibatide in acute coronary syndrome
without elevation of ST segment]. | Clinical effects of glycoprotein (GP) IIb-IIIa antagonist eptifibatide
(Integrilin) and its inhibitory effects on platelet aggregation were studied
upon administration of eptifibatide for the treatment of acute coronary syndrome
(ACS) without ST segment elevation. Eptifibatide was introduced to 25 patients
with uns... |
27,049 | [Antiatherogenic effects of angiotensin converting enzyme inhibitors from
positions (point of view) of evidence based medicine. Part I]. | In a series of two articles the authors present data from controlled trials in
which cardio-, cerebro-, and vasoprotective effects of angiotensin converting
enzyme inhibitors (ACEI) were assessed. The first communication deals with
results of randomized studies in most of which no objective proof of
antiischemic (a... |
27,050 | [Hypertrophy of left ventricular myocardium as modifiable risk factor: novel
possibilities of correction]. | Hypertrophy of left ventricular myocardium observed in 15-20% of patients with
arterial hypertension is an independent factor which elevates considerably risk
of complications of hypertension (ischemic heart disease, chronic heart failure,
ventricular arrhythmias). Regression of left ventricular hypertrophy (LVH) at... |
27,051 | [Pulmonary hypertension and right ventricular failure. Part II. Patients with
left ventricular involvement]. | In a series of articles the authors discuss literature data concerning
epidemiology of pulmonary hypertension, modern classification; peculiarities of
its pathogenesis and treatment in various diseases and conditions. In the second
part they consider peculiarities of pathogenesis of pulmonary hypertension and
right... |
27,052 | [Peculiarities of lipid disorders in patients with type II diabetes mellitus: in
which cases we should administer statins?]. | Cardiovascular complications are a principal cause of death rate in the patients
with type 2 diabetes, that in turn contribute to cardiovascular diseases and
complications in adult population. According to UKPDS data high LDL Ch level is
strong predictor of CHD development in patients with type 2 diabetes and its 1 ... |
27,053 | [Effect of therapy with rosuvastatin on lipid spectrum, factors of inflammation
and endothelial function in patients with ischemic heart disease]. | Rosuvastatin (10 mg) was given for 3 months to 30 men (mean age 57+/-9 years)
with total cholesterol (CH) above 5.2 mmol/l. Questioning, physical examination,
registration of ECG, measurement of levels of total, low density lipoprotein
(LDL), high density lipoprotein (HDL) CH, and triglycerides (TG), assessment of
... |
27,054 | [Peculiarities of atherosclerotic injury of carotid arteries in patients with
coronary artery disease with hyperhomocysteinemia]. | Peculiarities of atherosclerotic injury of carotid arteries were studied in 47
patients with coronary artery disease in dependence of blood concentration of
homocysteine. The patients were divided in 2 groups -- with homocysteine
concentration more and less than 10 mmol/l, and in 4 groups, corresponding to
quartile... |
27,055 | [Phenomenon of ischemic preconditioning and myocardial reserve in patients after
myocardial infarction]. | In order to assess effect of ischemic preconditioning (IP) on the level of
myocardial reserve in patients after myocardial infarction we divided 78
patients into 2 groups -- with and without IP. It was shown that presence of IP
in postinfarction period was associated with better parameters of systolic and
diastolic... |
27,056 | [Treatment of depression in patients with myocardial infarction with
tianeptine]. | AIM: To study efficacy and acceptability of tianeptine in treatment of
depression in patients with myocardial infarction (MI).
MATERIAL AND METHODS: A group of 416 patients (253 men and 163 women) from 35
till 89 years old with MI was studied. Depression was diagnosed in 113 of them
(27.2 %) by the use of Zung depre... |
27,057 | [Cardiac sympathetic innervation in patients with ventricular arrhythmias: an
assessment by 123I-metaiodobenzylguanidine scintigraphy]. | The aim of this study was to determine the state of sympathetic innervation in
patients with ventricular arrhythmias (VA) using 123I-metaiodobenzylguanidine
123I -MIBG) scintigraphy. Fifty six patients (26 men and 30 women, mean age
37.4+/-11,6) underwent single-photon emission computed tomography (SPECT)
imaging a... |
27,058 | [Comparative assessment of hypotensive, metabolic, and endothelial effects of
indapamide-retard and hydrochlorothiazide in patients with essential
hypertension]. | AIM: To compare hypotensive, metabolic, and endothelial effects of
indapamide-retard and hydrochlorothiazide.
MATERIAL AND METHODS: Patients (n=50) with essential hypertension were given
either indapamide-retard (1.5 mg/day, n=25) or hydrochlorothiazide (25 mg/day,
n=25) for 12 weeks. Dynamics of the following param... |
27,059 | [Hypotensive, organoprotective, and metabolic effects of Angiotensin converting
enzyme inhibitor moexipril in women with postmenopausal syndrome]. | Hypotensive, organoprotective, and metabolic effects of angiotensin converting
enzyme inhibitor moexipril (7.5-15 mg/day for 16 weeks) with or without
combination with hydrochlorothiazide was studied in 34 women (mean age
59.6+/-1.6 years) with postmenopausal metabolic syndrome and hypertension.
Thirty four women h... |
27,060 | [Short term simvastatin use in patients with heart failure of ischemic origin.
Changes of blood lipids, markers of inflammation and left ventricular function]. | AIM: To study changes of left ventricular function and some markers of
inflammation during use of simvastatin in patients with ischemic systolic heart
failure.
METHODS: Statin naive patients (n=70) with coronary heart disease (CHD), NYHA
class II-IV HF and LV ejection fraction (EF) 35% or less after 1 month of
stab... |
27,061 | [Peculiarities of regulation of cardiac function in some mammals]. | We studied acetylcholine induced changes of action potentials (AP) in ventricles
and atria of bat, hedgehog, yakut ground squirrel, and laboratory mice. In atria
of all these species of mammals acetylcholine caused pronounced dose dependent
shortening of AP. However sensitivity of ventricles of studied animals to
a... |
27,062 | [Effect of ubiquinone on contractile function and antioxidant status of the
myocardium in spontaneously hypertensive rats]. | During the period of aging of spontaneously hypertensive rats (SHR) between 6
and 13 weeks the systolic arterial pressure increased from 131+/-2 up to 176+/-3
mm Hg while in the control group of WKY rats it reached 122+/-2 mmHg. The
hypertension was combined with myocardial hypertrophy -- the relative weight of
SHR... |
27,063 | [Pulmonary hypertension and right ventricular failure. Part IV. Chronic lung
disease]. | In a series of articles the authors discuss literature data concerning
epidemiology of pulmonary hypertension, its modern classification; peculiarities
of its pathogenesis and treatment in various diseases and conditions. In the
forth lecture they present literature data on prevalence of chronic cor
pulmonale among... |
27,064 | [Angiotensin converting enzyme inhibitors in acute period of myocardial
infarction: the place of zofenopril]. | Acute myocardial infarction (MI) is one of main predecessors of chronic heart
failure (CHF), for the treatment of which angiotensin converting enzyme
inhibitors (ACEI) are recommended at present. It seems logical to prescribe ACEI
in early period of MI in order to prevent development of CHF in postinfarction
period... |
27,065 | [Assessment of clinical course, prognosis and effectiveness of drug and nondrug
treatment of patients with ischemic heart disease and occlusive coronary artery
atherosclerosis (data of 5-year prospective follow-up)]. | Data of 5-year prospective follow-up were used for assessment of clinical
course, prognosis and effectiveness of drug and nondrug treatment of 202
patients with ischemic heart disease, occlusive coronary artery atherosclerosis
and preserved left ventricular function. It was found that 5-year cardiovascular
mortalit... |
27,066 | [Ischemic cardiomyopathy: remote complications and their prognostication after
isolated myocardial revascularization]. | Aim of investigation was to study rate of remote cardiovascular complications
after aorto-coronary grafting (ACG) in patients with ischemic cardiomyopathy and
revelation of informative pre- and early postoperative markers of left
ventricular (LV) function for determination of prognosis of cardiovascular
complicatio... |
27,067 | [Early use of gemfibrozil in patients with non ST Elevation acute coronary
syndrome. Changes of markers of inflammation and von Willebrand factor]. | It is not known whether PPAR-alpha agonist gemfibrozil is able to exert rapidly
its lipid modulating, potential antiinflammatory and antithrombotic effects in
patients with non-ST elevation acute coronary syndrome (NSTEACS), as some other
lipid lowering drugs e.g. statins do.
METHODS: We randomized 44 patients with ... |
27,068 | [Possible role of hyperinsulinemia in pathogenesis of acute and chronic cardiac
failure in patients with ischemic heart disease (data of clinical studies)]. | Changes of blood insulin content were studied in patients with ischemic heart
disease with various functional classes of acute and chronic heart failure and
at different disease stages. It was established that latent hyperinsulinemia
which became evident at induced myocardial ischemia was present on all stages of
d... |
27,069 | [Preclinical assessment of disturbances of vascular and vegetative reactivity of
peripheral blood circulation in young men (students) with risk factors of
atherosclerosis]. | Hemodynamics of forearm and neurovegetative status were studied in 142
clinically healthy male students with risk factors of atherosclerosis and in 54
male students without risk factors of atherosclerosis at rest and during test
with reactive hyperemia. Rheovasography of forearm, cardiointervalography,
Doppler exam... |
27,070 | [Adipose tissue stromal cells -- multipotent cells with therapeutic potential
for stimulation of angiogenesis in tissue ischemia]. | Results of studies of properties of adipose tissue stromal cells are summarized
in this review. It contains data on separation and cultivation of these cells as
well as description of their antigenic characteristics, ability to differentiate
into cells of mesenchymal and nonmesenchymal origin, angiogenic potential, ... |
27,071 | [Pulmonary hypertension and right ventricular failure. Part V. Therapy in the
patients with chronic obstructive pulmonary disease]. | In a series of articles the authors discuss literature data concerning
epidemiology of pulmonary hypertension, its modern classification; peculiarities
of its pathogenesis and treatment in various diseases and conditions. In the
fifth lecture they present literature data on nondrug interventions and drug
therapy of... |
27,072 | [Hormonal regulation of lipoprotein metabolism: the role in pathogenesis of
coronary heart disease]. | The character and role of hormonal dysregulation of lipoprotein metabolism
during postprandial hyperlipemia were studied in patients with coronary heart
disease (CHD) and hyperthyroidism as compared with healthy subjects. Pronounced
hypertriglyceridemia alongside with the decreased high density lipoprotein
choleste... |
27,073 | [Value of various criteria of assessment of a test in stress echocardiography in
diagnosis of ischemic heart disease]. | Aim of investigation was to study significance of electrocardiographical and
echocardiographical criteria of development of angina attack, and their
combination in assessment of results of stress echocardiographical tests
(stress-echo) with various stress-agents. Stress echocardiography, coronary
angiography and le... |
27,074 | [Temporary cardiac pacing in patients with acute myocardial infarction in the
conditions of air medical service]. | Temporary electrical cardiac pacing in the conditions of air medical service was
used in 183 patients with myocardial infarction complicated with life
threatening disturbances of cardiac rhythm and conduction. Immediate results of
treatment, complications, and causes of lethal outcomes are presented. Two
groups of ... |
27,075 | [Effectiveness and safety of clopidogrel bisulfate in complex therapy of
patients with acute coronary syndrome with ST segment elevation]. | Efficacy of clopidogrel in acute myocardial infarction (AMI) was studied only in
two trials. However efficacy and safety of loading dose of this drug and its
long-term effectiveness were not studied in these trials.
AIM: To assess effects of clopidogrel loading dose and long term therapy in
addition to standard trea... |
27,076 | [Effects of long term therapy with angiotensin converting enzyme inhibitor
quinapril, antagonist of receptors to angiotensin II valsartan, and combination
of quinapril and valsartan in patients with moderate chronic heart failure. Main
results of the SADKO-CHF study]. | AIM: To compare effects of therapy with angiotensin converting enzyme inhibitor
quinapril (Q), angiotensin II receptor antagonist valsartan (V), and their
combination in patients with stable moderate chronic heart failure (CHF).
MATERIAL AND METHODS: Patients (n=80) with NYHA class II-III CHF due to ischemic
heart d... |
27,077 | [C-reactive protein level and rate of detection of autoantibodies to
beta(1)-adrenoreceptors in patients with supraventricular tachyarrhythmias]. | In order to assess concentration of C-reactive protein (CRP) and prevalence of
autoantibodies against beta(1)-adrenoreceptors (abeta(1)-AR) in patients with
cardiac supraventricular arrhythmias we studied 53 patients with arrhythmias and
20 healthy control subjects. Patients with idiopathic arrhythmias (atrial
fibr... |
27,078 | [Comparative study of the antiarrhythmic activity of magnesium aspartate L-, D-
and DL-aspartate stereoisomers]. | It seems an established fact that magnesium (Mg) aspartate is effective in
prophylaxis and adjuvant therapy of cardiac arrhythmia (e.g. prevention of toxic
symptoms during therapy with digoxin). There are claims that L-aspartate salts
are better delivery forms for cations such as Mg than D-aspartate salts, and Mg
L... |
27,079 | [Innervation of adrenal glands in some types of cardiovascular pathology]. | We examined adrenal glands obtained at early autopsy of 56 men aged 21-70 years.
According to the age five groups of cases were distinguished. The study was
performed with the use of methods of silver impregnation of nerve plexuses and
planimetric pointcounting. Density of nerve plexuses in adrenal medulla was
sign... |
27,080 | [Moexipril and cardiovascular diseases in women: is there a reason for
optimism?]. | Angiotensin converting enzyme (ACE) inhibitors are first line preparations in
the treatment of chronic heart failure irrespective of etiology. However there
are numerous proofs that in women drugs of this group exert less pronounced
favorable prognostic influence compared with men. Moexipril is an ACE inhibitor
whi... |
27,081 | [Specific features of impairment of systolic and diastolic left ventricular
functions in patients with acute myocardial infarction complicated with
pulmonary edema]. | The purpose of the study was to investigate specific features of systolic and
diastolic functions of the left ventricle (LV) in patients with acute myocardial
infarction (AMI), complicated by acute left ventricular failure (ALVF) and to
estimate their prognostic value. We examined 90 patients with AMI. The following... |
27,082 | [Combination treatment with coenzyme Q10 and simvastatin in patients with
coronary atherosclerosis]. | In order to assess efficacy of one of natural antioxidants--coenzyme Q10 (90 mg
daily) and its combination with simvastatin (10 mg daily) 44 outpatients with
coronary atherosclerosis were examined. Twenty four patients had undergone
coronary artery bypass surgery, 12--coronary angioplasty and in 8 coronary heart
di... |
27,083 | [Clinical application of spirapril in patients with arterial hypertension
combined with chronic obstructive pulmonary disease]. | In this study quadropril (Spirapril, Pliva) was given for 2 months to patients
with arterial hypertension combined with chronic obstructive pulmonary disease.
The results show that quadropril (6 mg/day) is highly effective as monotherapy
in patients with mild and moderate hypertensive disease. Its effects appear as ... |
27,084 | [Attitude of district internists to the problem of secondary prevention of
ischemic heart disease (results of a special questionnaire survey)]. | Attitude of district internists to the realization of a concept of secondary
prevention (SP) of ischemic heart disease was studied in one of large cities in
Russia. Among preparations most necessary for SP the following were named:
b-blockers (79.5%), angiotensin converting enzyme inhibitors (49.3%),
antiaggregants... |
27,085 | [Distribution of nitric oxide synthase in human intracardiac ganglia]. | This is the first study to report presence of nitric oxide synthase (NOS) in the
human intracardiac nervous cells. By applying immunohistochemical technique it
was shown that majority of neuronal perikaryons contain NOS 1 (neuronal NOS). We
conclude that in human heart about half of neurons have NO-ergic phenotype. ... |
27,086 | [Ivabradine--the first selective and specific I(f) inhibitor, novel preparation
for treatment of stable angina]. | Results of large epidemiological studies allowed to establish that heart rate
(HR) is an independent risk factor, elevating rates of total, cardiovascular and
sudden mortality. Ivabradine bounds specifically with f channels of sinus node
cells providing HR lowering. In experiments with the use of the method of
regi... |
27,087 | [Non-compact left ventricular myocardium: current state of the problem]. | Non-compaction of the left ventricle or spongy myocardium is a rare congenital
cardiomyopathy which is characterized by impaired endomyocardial morphogenesis,
hypertrophy of left ventricular myocardium with prominent trabeculation, and
deep inter-trabecular recesses. According to WHO classification (1995) this
dise... |
27,088 | [13-year result after implantation of intracoronary stent (treatment of
progressing atherosclerosis of coronary arteries with the help of endovascular
methods)]. | Clinical case of implantation in anterior interventricular artery (AIA ) of the
first coronary stent in Russia is presented. Control angiogram obtained 7 years
after stenting showed stent patency without restenosis with maximal 15.68%
in-stent stenosis. Angiogram obtained after 13 years revealed good patency of
pre... |
27,089 | [Randomized FARVATER Study. Part 1. Effect of 10 and 20 mg/day atorvastatin on
levels of lipids, C-reactive protein, and fibrinogen in patients with ischemic
heart disease and hyperlipidemia]. | Main aim of the clinical study FARVATER was comparison of effects of 10 and 20
mg/day of atorvastatin on levels of lipids, high-sensitivity C-reactive protein
(CRP), fibrinogen (F), and structural-functional state of vascular wall in
patients with documented and primary hyperlipidemia (HLP). Fifty patients (mean
ag... |
27,090 | [Effect of Lorazepam on emotional status and quality of life of patients with
ischemic heart disease]. | AIM: To investigate emotional status and quality of life of patients with
ischemic heart disease (IHD) with various anxiety and effect of therapy with
benzodiazepine anxiolytic lorazepam on these parameters.
MATERIAL AND METHODS: Hospital scale of anxiety and depression, Beck Depression
Inventory, and Seattle Questi... |
27,091 | [Clinico-metabolic and anti-ischemic effects of angiotensin converting enzyme
inhibitor lisinopril and its role in the process of left ventricular remodeling
in patients with diabetic heart]. | Clinico-metabolic and anti-ischemic effects of lisinopril and its influence on
processes of left ventricular remodeling were studied on 64 patients with
ischemic heart disease and stable class II-III effort angina combined with type
2 diabetes mellitus; 30 patients received standard therapy, 34--standard therapy
pl... |
27,092 | [Dynamics of left ventricular longitudinal function in patients with arterial
hypertension during therapy with angiotensin converting enzyme inhibitor
moexipril]. | AIM: To assess left ventricular longitudinal systolic and diastolic function in
patients with arterial hypertension in whom regression of left ventricular (LV)
hypertrophy (LVH) occurred at the background of long term therapy with
angiotensin converting enzyme inhibitor moexipril and hydrochlorothiazide.
MATERIAL AN... |
27,093 | [Rational approach to selection of antihypertensive therapy in persons with
metabolic syndrome: efficacy of monotherapy with spirapril and its combination
with retard form of nifedipine]. | AIM: Achievement of target blood pressure (BP) levels in subjects with metabolic
syndrome (MS) by the method of stepwise antihypertensive therapy and assessment
of metabolic effects of combination of spirapril and nifedipine retard.
MATERIAL AND METHODS: Patients (n=20, 12 women, 8 men, mean age 54+/-3 years)
with M... |
27,094 | [Advantages of restoration and maintenance of sinus rhythm in middle aged
patients with atrial fibrillation and chronic heart failure]. | Patients (n=223, age 47-64 years) with persistent nonvalvular atrial
fibrillation and functional class II-III chronic heart failure were treated for
2 years with aims of sinus rhythm control (n=113, strategy 1) or slowing of
heart rate (n=110, strategy 2). Strategy 1 compared with strategy 2 was
associated with low... |
27,095 | [Prognosis of Kaunas men population (15 years and older) survival]. | The use of automated informational data processing system (created in 1988-1989)
allowed to accumulate unique information on the health status of 12,241 men aged
over 15 years. Data base includes information on risk factors (arterial
hypertension, excess weight, smoking), occupation and character of work,
requireme... |
27,096 | [Plasminogen activators and matrix metalloproteinases during arterial
remodeling]. | To evaluate the role and interaction of plasminogen activators and matrix
metalloproteinases (MMPs) in arterial remodeling in vivo we compared effects of
recombinant urokinase- (uPA) and tissue-type (tPA) plasminogen activators on
vessel morphology, cell proliferation, inflammatory reaction and MMPs expression
in a... |
27,097 | [Why it is necessary to reduce heart rate in the treatment of stable angina?]. | The article is devoted to the role of heart rate (HR) as a risk factor of
cardiovascular morbidity and mortality in patients with stable angina. It
includes data from epidemiological surveys showing the value of elevated HR as a
risk factor in many cardiovascular diseases. HR reducing therapy as one of
cornerstone ... |
27,098 | [Prognostic significance of troponin T and MB creatine kinase elevations after
percutaneous coronary interventions in patients with ischemic heart disease]. | AIM: To compare prognostic significance of troponin T (TnT) and MB creatine
kinase (MB CK) elevations after percutaneous coronary interventions (PCI).
MATERIAL AND METHODS: Patients with ischemic heart disease (n=122) were followed
for 9+/-3 months after PCI. Coronary angiography was repeated in 79% of cases.
Compos... |
27,099 | [Effect of delayed coronary angioplasty after thrombolytic therapy on outcome of
acute myocardial infarction]. | Patients with acute myocardial infarction (n=161) were in random order divided
into 2 groups: (1) those who received thrombolytic therapy (TT), (n=126), (2)
those who received TT, optimized coronary angioplasty (TT+CA) on days 2-7
(n=35). During hospital period we assessed systolic and diastolic left
ventricular (L... |
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