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27,200 | [Pronounced homeostatic action of angiotensin converting enzyme inhibitors with
high affinity to tissue renin-angiotensin-aldosterone system on cellular
membranes]. | Endothelial dysfunction is considered in the paper from the point of view of
pathology of cellular membranes presenting as vesiculation of cytoplasmatic
membrane, release of membrane-bound microparticles, elevation of concentration
of peeled off endotheliocytes in the blood. Comparative analysis of action of
angiot... |
27,201 | [Primary prevention of cardiovascular diseases: long term results of five year
long preventive intervention in 12-year old boys (ten year prospective study)]. | In a longitudinal cohort (prevention group, n=213, comparison group, n=163) of
10-year prospective follow-up we addressed efficacy of 5-year-long multifactor
preventive intervention, conducted in a sample of population of 12 year old
boys. Preventive intervention was carried out both at populational level and
among... |
27,202 | [Pulmonary hypertension and right ventricular failure. Part XII. Nitrous oxide
and phosphodiesterase inhibitors in the treatment of primary pulmonary arterial
hypertension]. | In a series of articles the authors discuss literature data concerning
epidemiology of pulmonary arterial hypertension (PAH), its modern
classification; peculiarities of its pathogenesis and treatment in various
diseases and conditions. The twelfth communication contains consideration of
inhaled nitrous oxide and t... |
27,203 | [Coronary angioplasty: view through 30 years]. | Andreas Gruentzig executed the first successful percutaneous transluminal
coronary angioplasty (PTCA) in 1977. Percutaneous coronary interventions (PCI)
have considerably changed since this time. The changes have touched the
technical equipment for PCI, the pharmacological and mechanical support of PTCA
also. The s... |
27,204 | [Central arterial pressure: a necessary parameter for assessment of
cardiovascular risk and efficacy of antihypertensive therapy]. | Most of large controlled randomized trials have not revealed superiority of
"new" over "old" antihypertensive drugs and posed a question of value of
surrogate criteria for comparison of various treatment regimes. Data of
ASCOT-CAFE trials allow to assume that estimation of central blood pressure (BP)
opens novel pe... |
27,205 | [An experience of the use of stents with drug coating in patients with long and
diffuse coronary artery lesions]. | Treatment of long and diffuse lesions of coronary arteries remains one of most
complicated sections of endovascular treatment. From 2003 to 2005 treatment with
the use of stents with drug coating was conducted in 198 patients with long and
diffuse coronary artery lesions. This made up 26% of total number of patients... |
27,206 | [Noninvasive methods of investigation of mammary coronary grafts and coronary
vascular bed in remote period after coronary artery bypass grafting]. | Aim of the present study was to investigate diagnostic value of treadmill test,
stress echocardiography during exercise on treadmill as well as color duplex
scanning in assessment of the state of mammary coronary grafts and coronary
vascular bed in remote period after coronary artery bypass grafting. Parameters
of ... |
27,207 | [First in Russia experience of radiofrequency ablation with the help of robotic
system of magnetic navigation on the occasion of heart rhythm disturbances]. | We present first in Russia experience of interventional treatment of 15 patients
(11 men, 4 women, mean age 34.2 +/- 13.9 years) in whom operations of
endocardial electrophysiological study (endoEPS) and radiofrequency ablation
(RFA) with the help of robotic system of magnetic navigation were carried out
because of... |
27,208 | [Activity of inflammatory-destructive changes in the process of formation of
unstable atherosclerotic plaque]. | We studied parameters of inflammatory (tumor necrosis factor a, antagonist of
interleukin-1 receptor, interleukin-6 , interleukin-8, C-reactive protein) and
destructive (matrix metalloproteinases type 3 and 9, tissue inhibitor of
metalloproteinase type 1) processes in dynamics of sequential stages of
development of... |
27,209 | [Therapeutic education of social workers: first results]. | For the improvement of compliance of old age patients to therapy of chronic
heart failure (CHF) we carried out therapeutic training of social workers
serving these patients at their homes. Efficacy of training was assessed by
means of analysis of questionnaires given to 87 social workers before and after
training s... |
27,210 | [Hypercholesterolemia in men and women of various age. Part I. Clinical and
prognostic significance]. | There no doubts that hypercholesterolemia and elevated concentrations of low
density lipoprotein (LDL) cholesterol (Ch) especially is one of main risk
factors of premature development of ischemic heart disease (IHD) in middle aged
men. Proofs of dependence of development of IHD on Ch and LDL-Ch levels in
middle age... |
27,211 | [The place of acetylsalicylic acid in the modern cardiovascular
pharmacotherapy]. | Acetylsalicylic acid (ASA) is effective antiplatelet agent in many groups of
patients with cardiovascular disorders. Efficacy and safety of ASA was confirmed
in many trials and meta-analyses. But the optimal dose of ASA in different
conditions is still uncertain. ASA is effective in all forms of coronary heart
dise... |
27,212 | [Efficacy and safety of long-term application of spironolactone in patients with
moderate and severe chronic heart failure receiving optimal therapy]. | Aim of the investigation was the study of influence of spironolactone (25 - 75
mg/day) on clinico-functional status, parameters of left ventricular (LV)
remodeling, as well as safety of its long term application in patients with
chronic heart failure (CHF) receiving optimal therapy. Forty nine patients were
include... |
27,213 | [Depressive symptoms worsen prognosis in patients with arterial hypertension and
ischemic heart disease: first results of prospective phase of Russian
multicenter study COORDINATA]. | COORDINATA - Russian multicenter prospective (3 year long) study having the aim
to elucidate influence of symptoms of anxiety and depression on cardiovascular
(CV) prognosis in patients with arterial hypertension (AH) and ischemic heart
disease (IHD). Results of 1.5 years of prospective phase of the study are
prese... |
27,214 | [Hypotensive activity and cerebroprotective properties of carvedilol in patients
with arterial hypertension associated with type 2 diabetes mellitus]. | Aim of the study was to elucidate peculiarities of influence of carvedilol on
24-hour blood pressure (BP) profiles and changes of parameters of cerebral
perfusion in patients with arterial hypertension (AH) associated with type 2
diabetes mellitus. Investigations were performed in 30 patients with I-III
degree AH a... |
27,215 | [The role of noninvasive methods of investigation in diagnosis of
atherosclerosis]. | Visualization of the myocardium with the use of various high technologies gains
more and more important significance in diseases of cardiovascular system. Large
value for investigations of the heart and blood vessels have acquired methods of
echocardiography, magnetic resonance tomography, spiral computed tomography... |
27,216 | [Peculiarities of atherosclerotic damage of brachiocephalic arteries in patients
with type 2 diabetes mellitus]. | The state of vascular bed of brachiocephalic arteries was studied by the method
of color duplex scanning in 250 patients (116 men and 134 women) with
atherosclerosis of various vascular basins which in 62 of them took place at the
background of type 2 diabetes mellitus (DM). Two hundred five patients had
atheroscle... |
27,217 | [Effect of thrombolytic therapy on parameters of endothelial function in
patients with myocardial infarction]. | THE AIM OF STUDY: A comparative estimation of influence various thrombolytic
preparations(alteplase, Streptokinase) on clinical course and the remote
forecast of disease, and also of parameters of a metabolism of nitric oxide of
the patient with acute myocardial infarction.
MATERIAL AND METHODS: In research have inc... |
27,218 | [Tissue dopplerography of the myocardium in diagnosis of myocardial involvement
in patients with rheumatoid arthritis]. | Inflammatory rheumatoid damage of the heart is in most cases oligosymptomatic
but it can lead to development of heart failure and cause lethal outcomes.
AIM OF THE STUDY: To detect asymptomatic myocardial involvement in patients with
rheumatoid arthritis (RA) with the help of tissue dopplerography (TDG) of the
myoca... |
27,219 | [Peculiarities of cardiovascular and metabolic disturbances in women after
ovariectomy]. | Metabolic dysfunction and the state of cardiovascular system were studied in 80
women with surgical climacterium. Dynamics of metabolic syndrome formation and
left ventricular structural-functional changes were investigated. It was
confirmed that the majority of patients with surgical climacterium developed
metabol... |
27,220 | [Clopidogrel resistance: myth or reality]. | The efficacy of clopidogrel, as an established anti-platelet agent for the acute
coronary syndrome treatment and for the thrombotic complications prevention
after percutaneous coronary angioplasty and coronary artery stenting has been
supported by the evidence of several major randomized clinical trials. However,
s... |
27,221 | [Is patient education a factor elevating efficacy of arterial hypertension
control?]. | Unsatisfactory control of arterial hypertension is to a great extent determined
by low compliance of patients to treatment, which can be caused by insufficient
information about the disease and lack of proper motivation. Special methods
were elaborated for elevation of level of awareness of patients - from one-time ... |
27,222 | [Retrograde recanalization of coronary artery occlusions: novel method for
increase of the rate of successful interventions]. | First results of the use of a novel method of percutaneous coronary angioplasty
of chronic occlusions of coronary arteries are presented. In 8 patients (men
aged 54 - 75 years, mean age 60,4 +/- 7.1 years, mean duration of occlusion 45.5
+/- 7.9 months) retrograde recanalization was carried out through collateral
b... |
27,223 | [Autotransplantation of the heart as the method of treatment of congestive heart
failure]. | Congestive heart failure with preserved or moderately lowered left ventricular
pump function in some patients is caused by mitral regurgitation. Its
consequences are left atrial dilation, pulmonary hypertension, tricuspid
regurgitation, thromboembolic complications, disturbances of rhythm with
elevated risk of sudd... |
27,224 | [Effect of rosuvastatin therapy and myocardial revascularization on angiogenesis
in coronary artery disease patients]. | We studied the influence of rosuvastatin therapy and myocardial
revascularization on angiogenic growth factors in coronary artery disease (CAD)
patients. Two main groups were examined: the first one consisted of patients
passed through successful percutaneous coronary intervention (PCI), the second
one consisted of... |
27,225 | [Influence of valsartan, fluvastatin extended release and their combination on
arterial pressure, parameters of lipid metabolism, and endothelial function in
patients with hypertensive disease]. | BACKGROUND: Search of new optimal treatment strategies, allowing to decrease the
risk of atherosclerosis development and cardiovascular events is determined by
high prevalence of hyperlipidemia in hypertensive patients.
AIM: To study the vasoprotective effects and security of Valsartan (V) or
Fluvastatin extended re... |
27,226 | [Atherogenic oxidative and structural modification of low density lipoproteins
in men with coronary atherosclerosis]. | We studied parameters of structural and oxidative modification of low density
lipoproteins (LDL) in 80 men aged 35 - 65 years with coronary atherosclerosis
verified at coronary angiography in comparison with 80 men of the same age
without ischemic heart disease. Biochemical studies included determination of
paramet... |
27,227 | [Stages of compensation of circulation in acquired aortic valve disease
according to data of physical working capacity]. | We examined 194 men (mean age 40 +/- 1.4 years) with acquired aortic valve
disease. Basing on the data of estimation of physical working capacity and
reserve of cardiorespiratory system we assessed staging of development of
compensatory mechanisms of circulation in patients with acquired aortic stenosis
and aortic ... |
27,228 | [Prognostic factors of unfavorable outcome of thyrotoxic cardiomyopathy]. | Because of absence of investigations directed at study of quantitative
evaluation of prognostic factors of unfavorable outcome of thyreotoxic
cardiomyopathy (TCMP) it remains actual to investigate the course and variants
of outcomes of TCMP in various groups of patients differing by age, sex,
duration, and etiology... |
27,229 | [RELIPH -- REgularnoye Letcheniye I ProPHylaktika (Regular Treatment and
Prevention) -- the key to improvement of situation with cardiovascular diseases
in Russia: results of multicenter study. Part II]. | The paper presents results of the conducted in Russia large scale study "
REgularnoye Letcheniye I ProPHylaktika (Regular Treatment and Prevention) -- the
key to improvement of situation with cardiovascular diseases in Russia -- RELIPH
" on assessment of conformity of recommended by medical practitioners treatment
... |
27,230 | [Predictors of intracardiac thrombosis in patients with atrial fibrillation:
factors of hemostasis, markers of inflammation, and genetic factors]. | Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Many
patients with nonvalvular AF have substantial rates of stroke and
thromboembolism. The left atrial appendage (LAA) is a common source of cardiac
thrombus formation associated with systemic embolism. Recent findings have
suggested a link ... |
27,231 | [Frequency of detection the of Brugada syndrome signs in the course of ECG
registration]. | The aim of the study was to assess prevalence of the Brugada syndrome during
carrying out ECG in the conditions of medico-sanitary division of a large
industrial enterprise. Signs of the Brugada syndrome were found on 20 of 42779
ECGs (0.047%) registered during 1 year in patients aged 22-68 years. Type 2
syndrome w... |
27,232 | [Nonischemic ventricular arrhythmias: classification, clinical manifestations,
diagnosis, and treatment]. | Clinico-electrocardiographical and electrophysiological features of
noncoronarygenic ventricular arrhythmias are presented. Characteristics of
localization of arrhythmogenic focus in various parts of left and right
ventricular myocardium, in interventricular septum, and in immediate vicinity of
each of 4 valves are... |
27,233 | [Hypercholesterolemia in men and women of various age. Part II. The problem of
efficacy and safety of statins]. | Hypocholesterinemic drugs from the statins class are effective means of primary
and secondary prevention of ischemic heart disease (IHD) in middle aged men who
comprised predominant majority of patients participating in randomized
controlled trials (RCT). Proofs of favorable influence of statins on origination
and ... |
27,234 | [Possibilities of diagnosis of non-ST elevation acute coronary syndrome in old
subjects]. | Diagnosis of non-ST elevation acute coronary syndrome (NSTEACS) in old subjects
poses substantial difficulties because in a row of cases clinical picture and
changes on electrocardiogram are nonspecific. In this paper we discuss
possibilities of diagnosis of NSTEACS with the help of determination of markers
of myoc... |
27,235 | [Metalloproteinase activity of the blood in patients with arterial hypertension
with paroxysmal form of atrial fibrillation]. | Aim of the study was to investigate interrelationship between serum markers of
myocardial fibrosis: matrix metalloproteinase -1 (MMP-1), tissue inhibitor of
metalloproteinase-1 (TIMP-1) and parameters of echocardiography in patients with
arterial hypertension (AH) and paroxysmal form of atrial fibrillation (n=39). W... |
27,236 | [Influence of nebivolol on left ventricular remodeling in patients with arterial
hypertension without chronic heart failure]. | In the recent years the problem of heart remodeling under drugs in patients with
arterial hypertension (AH) have been extensively discussed. The beta-blocker of
the third generation nebivolol is known as a good antihypertensive agent. The
aim of our study was to evaluate effects of nebivolol on structural and
funct... |
27,237 | [The state of cerebral blood flow in hypertensive crises and possibilities of
its correction]. | We examined 60 patients with arterial hypertension admitted to hospital during
hypertensive crisis. Control group consisted of 30 patients with normal arterial
pressure. We investigated parameters of cerebral blood flow with the method of
transcranial dopplerography, content of NO and a row of cytokines
(interleuki... |
27,238 | [Interrelationship between changes of rate and variability of cardiac rhythm
under influence of beta-adrenoblockers]. | BACKGROUND: Beta-blocking agents (BB) decrease mortality particularly sudden in
post-myocardial infarction patients and in patients with chronic heart failure
that is closely related to heart rate (HR) lowering at rest. The hypothesis
exists that BB decrease mortality due to increase of cardiac vagal activity.
AIM: ... |
27,239 | [Changes of QT-interval duration in children and adolescents suffering from type
1 diabetes mellitus]. | We measured QT interval in 43 children and adolescents with type 1 diabetes
mellitus and studied its dependence on age, disease duration, metabolic control,
and dose of insulin. Control group consisted of 37 healthy children and
adolescents. Duration of QT during 24 hours was longer in patients as compared
with con... |
27,240 | [Influence of perindopril, rosuvastatin, or omega-3 polyunsaturated fatty acids
on efficacy of antirecurrence therapy with sotalol in patients with persistent
atrial fibrillation]. | Patients (n=187) with symptomatic persistent atrial fibrillation at the
background of ischemic heart disease after restoration of sinus rhythm were
randomized for treatment with sotalol 80 - 160 mg/day (n=48), or with
combinations of sotalol with perindopril 4 - 8 mg/day (n=48), rosuvastatin 5 -
20 mg/day (n=45), o... |
27,241 | [Matrix metalloproteinases: significance in remodeling of the myocardium in
valvular heart disease]. | AIM: To assess concentration of metalloproteinase (MMP) -9 and its inhibitor in
blood serum of patients with defects of left cardiac chambers, associated with
pressure or volume overload.
RESULTS: Elevation of MMP-9/TIMP-1 ratio at the account of MMP-9 was
characteristic for patients with volume overload while eleva... |
27,242 | [Long-term results of the use of hyperbaric oxygenation in patients with acute
myocardial infarction]. | Effect of hyperbaric oxygenation (HBO) on mortality and rate of development of
reinfarctions during 24 month follow-up was studied in 129 otherwise
conventionally treated patients with acute myocardial infarction (AMI). These
patients were randomly divided into control (n=65) and intervention (n=64)
groups. In the ... |
27,243 | [The role of genetic factors in development of atrial fibrillation]. | The review is devoted to problems of pathogenesis of atrial fibrillation and
role of genetic factors in its development. Significance of genetic factors for
origination of atrial fibrillation has been proved by aggregation of the disease
in families. This review contains consideration of main candidate genes possibl... |
27,244 | [Pulmonary hypertension and right ventricular failure. Part XIII. Surgical
methods of treatment of various forms of pulmonary arterial hypertension]. | In a series of articles the authors discuss literature data concerning
epidemiology of pulmonary arterial hypertension (PAH), its modern
classification; peculiarities of its pathogenesis and treatment in various
diseases and conditions. The 13-th communication contains consideration of
surgical and interventional p... |
27,245 | [Significance of various methods of assessment of functional state for
cardiovascular risk stratification]. | Arterial hypertension (AH) combined with diabetes mellitus accelerates
development of damage of the kidney. Elevation of serum creatinine level,
lowering of creatinine clearance or calculated glomerular filtration rate (GFR),
microalbuminuria are independent prognostic factors of cardiovascular morbidity
and mortal... |
27,246 | [The role of multidetector computed tomography in detection of myocardial
infarction]. | The aim of the study was to assess the diagnostic value of multidetector
computed tomography (MDCT) in detection of myocardial infarction (MI) in acute
and chromic stages.
MATERIAL AND METHODS: 49 patients with suspected MI were included in the study.
In 44 patients the diagnosis of acute MI had been confirmed accor... |
27,247 | [Diagnostic value of CT angiography in coronary arteries stenosis detection]. | BACKGROUND: Noninvasive imaging of coronary arteries is very important. CT
angiography (multislice computed tomography and electron beam computed
tomography -- MSCT and EBT) is most reliable method for noninvasive coronary
visualization.
PURPOSE: The aim of our study was to evaluate the diagnostic value of CT
angio... |
27,248 | [First experience with the use of a clip device for closure of arterial approach
after endovascular treatment of coronary arteries]. | Aim of the present study was assessment of the StarClose Vascular Closure System
- novel device for mechanical closure of femoral artery puncture site. We
included in this study 29 patients in whom after procedure of endovascular
treatment puncture site was closed with the given device. Control group
comprised 34 p... |
27,249 | [Complications of stress-echocardiography used for diagnosis of ischemic heart
disease]. | Prevalence of minor and major complications, side effects of stress
echocardiography (stress-echoCG) was studied in a group of 1359 patients with
suspected ischemic heart disease (IHD). Dipyridamole/atropine test was carried
out in 184, dobutamine/atropine test - in 231, transesophageal atrial pacing
(TEAP) - in 15... |
27,250 | [Heart fatty acid binding protein in patients hospitalized because of worsening
heart failure. Relation to prognosis of death]. | PURPOSE: We tested the hypothesis that serum heart fatty-acid binding protein
(FABP), an early marker of myocardial necrosis, is related to prognosis of
patients hospitalized because of worsening heart failure (HF).
METHODS: Sixty nine patients (64% men, age 66.6 +/- 11.0 years) with NYHA class
II, III, IV HF (1, 18... |
27,251 | [Peculiarities of systolic and diastolic function of left and right ventricles
in elderly and geriatric patients with stable effort class II-III angina during
formation of chronic heart failure]. | In order to reveal peculiarities of function of cardiac ventricles in functional
class (FC) II-III chronic heart failure (CHF) Doppler echocardiography (DE) and
myocardial tissue Doppler echocardiography (TDE) were carried out in 108 middle
aged, elderly and old patients. Patients with signs of FCIII CHF had pronoun... |
27,252 | [Contribution of CYP11B2, REN and AGT genes in genetic predisposition to
arterial hypertension associated with hyperaldosteronism]. | We carried out comparison of distribution of alleles and genotypes of
polymorphic loci of renin-angiotensin-aldosterone system genes: CYP11B2
(C-344T), AGT (Thr174Met) and REN (C-5434T, C-5312T, and A BglI G) and their
combinations in two groups of patients with low renin forms of arterial
hypertension (AH). Group ... |
27,253 | [Clinical efficacy of permanent cardiac pacing in patients with bradysystolic
forms of disturbances of cardiac rhythm and conduction]. | From 1996 to 2002 primary implantations of pacing systems because of
bradysystolic disturbances of cardiac rhythm and conduction had been carried out
in 311 patients. Indications were disturbances of atrioventricular conduction in
168 and sick sinus syndrome in 143 patients. According to type of permanent
pacing pa... |
27,254 | [Peculiarities of functional state of endothelium in women with polycystic
ovaries]. | To reveal factors of elevated risk of development of cardiovascular diseases we
examined 59 women with polycystic ovarian syndrome (PCOS). Control group
comprised 12 healthy body mass and age matched women. Functional state of
endothelium was assessed by endothelium dependent brachial artery dilation
(EDV), intima-... |
27,255 | [Endothelial progenitor cells: role in endothelial function recovery and
potential therapeutic application]. | Endothelial dysfunction and cell loss lead to atherosclerosis and its outcomes.
Several recent studies suggested that endothelial progenitor cells (EPCs) play a
key role in reendothelialization of injured vessels and in endogenous
neovascularization of ischemic tissues. Modulation of EPCs number and functional
acti... |
27,256 | [The problem of complications of percutaneous coronary interventions. Part I.
Character and frequency of complications]. | In recent years interventions in cardiology became routine procedure in many
clinics. This could not to affect frequency of complications. From the very
beginning of development of interventional cardiology specialists have been
showing great interest to monitoring of complications and to possibilities of
lowering ... |
27,257 | [The use of implantable cardioverter-defibrillators in patients at high risk of
sudden cardiac death]. | We have reviewed literature on contemporary views on sudden cardiac death (SCD),
detection of category of patients belonging to the group with high risk of SCD,
and methods of SCD prevention. Randomized studies on assessment of efficacy of
implantable cardioverter-defibrillators (ICD) for primary and secondary
prev... |
27,258 | [The system of hemostasis in patients with atrial fibrillation: markers of left
auricular thrombosis]. | Thrombosis of the left atrial appendage (LAA) is considered to be main cause of
thromboembolic complications of atrial fibrillation (AF). Aim of this work was
to study parameters of the hemostasis system in patients with AF in dependence
on the presence of thrombus in the LAA. We examined 92 patients (58 men and 34 ... |
27,259 | [Distribution of chemical elements in various parts of the heart of patients
with acute heart failure]. | By the method of autopsy in patients with ischemic heart disease (IHD) who died
of acute heart failure we took samples of myocardium from 6 parts of the heart:
left and right atrium, left and right ventricle, region of myocardial
infarction, and scar of the left ventricle. Simultaneously we conducted
histological s... |
27,260 | [Effect of long term therapy with spironolactone on parameters of 24-hour heart
rhythm variability and ventricular arrhythmias in patients with heart failure
receiving optimal therapy]. | Aim of the investigation was the study of influence of spironolactone (25-75
mg/day) on clinico-functional and neurohormonal, 24-hour variability of cardiac
rhythm, and ventricular disturbances of heart rhythm in patients with chronic
heart failure (CHF) receiving optimal therapy. Forty nine patients were included
... |
27,261 | [Recommendations on arterial hypertension 2007: text, context, and
speculations]. | At the Congress of the European Society on Arterial Hypertension (AH) in June
2007 in Milan were presented Second European Recommendations on AH traditionally
attracting huge attention. Novel Recommendations appear to be revision of the
2003 variant and in distinction to recommendations of WHO are oriented to more
... |
27,262 | [The problem of complications of percutaneous coronary interventions. Part II.
Peripheral complications]. | Peripheral complications related to diagnostic and curative catheterizations
remain to be serious problem in invasive cardiology. As annual number of
interventional procedures only increases questions of tactics and treatment of
peripheral vascular complications appear extremely actual. In recent decades
clear tend... |
27,263 | [Clinical and economical effectiveness of outpatient diagnostic coronary
angiography]. | Introduction into clinical practice of transradial coronary angiography (CA)
made it possible to conduct the procedure in outpatients and thus increase
number of CA and diminish its cost. Aim of the study was to assess possibility,
safety and economical efficacy of outpatient CA. Between April 2004 and August
2007 ... |
27,264 | [Genetic aspects of individual sensitivity to betaxolol in patients with
arterial hypertension]. | Association of polymorphism of b1-adrenoreceptors gene and cytochrome 2D6 gene
with efficacy of b-adrenoblocker betaxolol was studied in 81 patients with I and
II degree arterial hypertension. Betaxolol (10-20 mg/day) was given for 4 weeks,
its efficacy was assessed by office blood pressure (BP) measurements, 24-hou... |
27,265 | [Influence of polymorphism's of endothelial nitric oxide synthase gene and
polymorphism of NADPH oxidase gene on development of complications of arterial
hypertension]. | The aim of the study was to analyze the prevalence of polymorphism Glu298Asp of
endothelial nitric oxide synthase gene and C242T p22 phox polymorphism of NADPH
oxidase gene in patients with arterial hypertension (AH) and their influence on
AH complications. The study included 272 AH patients, average age 50,7 years.... |
27,266 | [Left ventricular hypertrophy and thickening of common carotid artery wall in
men aged 40 - 54 years with I degree arterial hypertension]. | We carried out clinical-instrumental examination of 456 men aged 40-54 years.
First degree arterial hypertension was revealed in 165 men. Left ventricular
hypertrophy was found in 48 (30%), increased intima-media thickness (IMT) - in
67 (41%) patients. There was significant medium power relationship between IMT
and... |
27,267 | [Cytochrome P4502C9(CYP2C9) gene polymorphism and safety of therapy with
warfarin]. | Aim of the study was to investigate frequency and influence of alleles CYP2C9*2
and CYP2C9*3 on pharmacokinetics, pharmacodynamics and dosing regimen of
warfarin and on development of hemorrhagic complications. We included 84
patients (mean age 62,8 +/- 10,5 years). Duration of follow-up varied between 1
month and ... |
27,268 | [Efficacy and safety of the use of metformin in patients with chronic heart
failure and type 2 diabetes mellitus. results of the study "rational effective
mulicomponent therapy in the battle against diabetes mellitus in patients with
chronic heart failure"]. | Aim of the investigation was to study safety of therapy with metformin and its
effect on clinical, hemodynamic, functional and neurohumoral status in patients
with chronic heart failure and type 2 diabetes mellitus DM). Eighty one patients
with light and moderate NYHA functional class (FC) II-III CHF, left ventricul... |
27,269 | [Peculiarities of cardiovascular syndrome in children and adolescents with
obesity in dependence of level of insulin resistance]. | We conducted complex study of the state of cardiovascular system in 157 children
aged 11-16 years with I-III degree obesity. Dazing on the results it is
suggested to include in cardiovascular syndrome in children with obesity
together with arterial hypertension syndrome of vegetative (autonomic)
dysfunction, manife... |
27,270 | [Pulmonary hypertension and right ventricular failure. Part XIV. Differentiated
therapy of primary (idiopathic) and associated forms of pulmonary arterial
hypertension]. | In a series of articles the authors discuss literature data concerning
epidemiology of pulmonary arterial hypertension (PAH), its modern
classification, peculiarities of its pathogenesis and treatment in various
diseases and conditions. The last 14-th communication contains consideration of
issues of differentiated... |
27,271 | [Peculiarities of cardiac involvement in patients with dystrophic myotonia]. | Dystrophic myotonia is a widespread hereditary disease. Pathological process
touches development and functioning of various organs and tissues: smooth and
skeletal muscular tissue, the heart, organ of vision, brain. Pathology of the
heart serves as one of frequent manyfestations of dystrophic myotonia.
Degenerative... |
27,272 | [Prehospital thrombolytic therapy with tenecteplase in patients with
ST-elevation myocardial infarction]. | We carried out prehospital thrombolytic therapy (TLT) with tenecteplase in 24
patients with ST-elevation myocardial infarction (MI) at the background of
standard concomitant therapy with unfractionated heparin, aspirin, and
clopidogrel and analyzed clinical course of MI, ECG dynamics, systolic left
ventricular func... |
27,273 | [Clinical efficacy of antihypertensive therapy of pregnant women with arterial
hypertension with long acting nifedipine and bisoprolol]. | Study aim was assessment of clinical efficacy of mono therapy with nifedipine
SR/GITS and combination of nifedipine SR/GITS and bisoprolol as well as
investigation of functional state of sympathoadrenal system (SAS) in pregnant
women with arterial hypertension. Examination and treatment with nifedipine
SR/GITS 30 m... |
27,274 | [Comparison of effects of nebivolol and atenolol on P-wave dispersion in
patients with hypertension]. | BACKGROUND: P-wave dispersion has been shown to be a noninvasive
electrocardiographic predictor for development of atrial fibrillation . Thus it
may be possible to attenuate atrial fibrillation risk through normalization of
P-wave variables and improvement in P-wave dispersion may be an important goal
in treatment ... |
27,275 | [RELIPH - regular treatment and prevention - the key to improvement of situation
with cardiovascular diseases in Russia: results of a Russian multicenter study
(part III)]. | The first results of a big Russian multicenter study " RELIF - Regular treatment
and prevention - the key of improvement of the situation with cardiovascular
diseases in Russia " are presented. The study examines the accordance of
arterial hypertension (AH) and coronary heart disease (CHD) treatment
recommended by ... |
27,276 | [Physiological significance and normative parameters of rate adaptation of
QT-interval during holter monitoring in healthy persons of young age]. | Aim of the investigation consisted in to study parameters of " QT-dynamics " in
healthy children and adolescents. We examined 26 children aged 7 - 17 years
(mean 11,6 +/- 7 years) - 7 girls (9,3 +/- 2,3 years) and 19 boys (12,5 +/- 3,6
years). Holter monitoring with manual and automatic estimation of QT and QTc
int... |
27,277 | [Effect of statins on content of lipids in intima of the human aorta data of
computer morphometry]. | We carried out pathomorphological study of fragments of the thoracic aorta
obtained at aorto coronary bypass surgery in order to elucidate effect of
statins on lipid component of vascular wall using the system of computer
processing and image analysis. Treatment of patients with ischemic heart disease
with statins ... |
27,278 | [Effect of sex on informative power of various electrocardiographical criteria
of left ventricular hypertrophy in patients with excessive body mass]. | Aim of the study was to analyze dependence of various voltage parameters of QRS
complex on increase of left ventricular myocardial mass (LVMM) in samples of men
and women with excessive body mass or obesity. We included data from 223
patients with excessive body mass and diagnosis of stage I - II arterial
hypertens... |
27,279 | [P wave dispersion in hypertensive urgency]. | BACKGROUND AND PURPOSE: P wave dispersion (PWD) has been accepted as a predictor
for atrial fibrillation (AF) in hypertension and some other cardiac diseases.
The aim of this study was to compare the P wave parameters between patients with
mild-moderate hypertension and those with hypertensive crises.
METHODS: A tot... |
27,280 | [The study of vasodilative and antiischemic function of nicorandil in regional
ischemia and reperfusion of rat heart in vivo]. | Aim of the work was to study effect of nicorandil [N-(2-nitrooxiethyl)
nicotinamide, SG75] on blood pressure (BP), heart rate (HR) and rhythm
disturbances during regional ischemia and reperfusion of the heart in rats in
vivo and its ability to limit acute myocardial infarction (MI). Nicorandil was
obtained by nitra... |
27,281 | [The study of therapeutic effect of synthetic bradykinin "gene" contained in
retrovirus vector on spontaneously hypertensive rats]. | Administration of DNA plasmid pPS-3-neo (brd) with synthetic bradykinin " gene "
to 2-days old male spontaneously hypertensive rats (SHR) leads to 2 weeks delay
in development of arterial hypertension. Lowering of SBP and positive results of
PCR DNA of various organs observed in synthetic bradykinin " gene " transge... |
27,282 | [Structural-functional parameters of the myocardium in patients with chronic
iron deficiency anemia]. | Aim of the study was investigation of structural-functional parameters of the
myocardium and assessment of segmental diastolic left ventricular function with
myocardial tissue dopplerography in 56 patients with iron deficiency anemia
(IDA). We studied parameters of structure of the myocardium, its
systolodiastolic ... |
27,283 | [The use of isoosmolar contrast medium for lowering of rate and clinical
significance of contrast-induced nephropathy in patients with diabetes
mellitus]. | As a contrast medium during percutaneous coronary intervention (PCI) we used
iodixanol in 31 patients with diabetes mellitus and various degree of impairment
of renal excretory function and amidotrizoate - in 12 patients with diabetes
mellitus without clinical signs of renal involvement. Blood plasma creatinine
(BP... |
27,284 | [The role of beta-adrenoblockers and If-inhibitor ivabradine in lowering of rate
of development of cardiac complications after carotid endarterectomy]. | Aim of the study was to assess effect of therapy with b-adrenoblockers and
If-inhibitors on the rate of development of coronary complications of carotid
endarterectomy. Patients (n=111, mean age 61 +/- 4 years) subjected to carotid
endarterectomy in 2006 - 2007 were divided into 3 groups according to therapy in
pre... |
27,285 | [The novel method of assessment of individual total cardiovascular risk for the
population of Russia]. | Novel innovative technology of assessment of level of total cardiovascular risk
with consideration of a broad list of parameters of the state of individual
health and its determining factors is described. The proposed model of risk is
based on results of 20-year prospective observation of large contingents of
popul... |
27,286 | [High frequency transthoracic echocardiography in diagnosis of chronic
occlusions of major coronary arteries]. | Comparative analysis of possibilities of transthoracic echocardiography (TTE)
and coronary angiography in diagnosis of chronic occlusions of anterior
descending (ADA), circumflex (CA), and right coronary (RA) arteries was carried
out in 100 patients (90 men, 10 women, mean age 51 +/- 11 years). With the help
of TTE... |
27,287 | [Objective methods of assessment of coronary angiogenesis]. | Stimulatiion of coronary angiogenesis in patients with IHD appears to be one of
perspective directions in contemporary cardiology. Therefore objective
assessment of results with the help of instrumental methods of investigation is
important. For assessment of the state of coronary vascular bed and myocardial
perfus... |
27,288 | [Efficacy and safety of enoxaparin use during drug-eluting stents implantation]. | We assessed possibility of the use of low molecular heparin enoxaparin during
percutaneous coronary interventions (PCI) with implantation of drug eluting
stents. Enoxaparin was administered to 225 (0.3 mg/kg intraarterially via
catheter) and 215 (0.5 mg/kg intravenously) patients. In comparison group
(n=207) we use... |
27,289 | [Resistance to antiplatelet drugs in patients with non ST elevation acute
coronary syndrome]. | Rate of resistance to aspirin and clopidogrel was assessed in 44 patients with
non ST elevation acute coronary syndrome. Platelet aggregation was studied by
method of Born. Criterion of resistance to aspirin was arachidonic acid induced
aggregation > or =20%. Patients with lowering of ADP induced aggregation < 10%, ... |
27,290 | [Clinico-economical efficacy of angiotensin converting enzyme inhibitors in
patients with arterial hypertension and ischemic heart disease]. | We conducted comparative analysis of clinico-economical efficacy of angiotensin
converting enzyme inhibitors as components of combination therapy of patients
with arterial hypertension and ischemic heart disease. Clinical efficacy of
fosinopril, moexipril, perindopril, and ramipril was comparable: in compared
group... |
27,291 | [Regression of left ventricular hypertrophy and improvement of its diastolic
function in patients with arterial hypertension under influence of
antihypertensive therapy]. | Antihypertensive therapy with sequential addition of drugs (noliprel,
noliprel-forte, metoprolol, amlodipine) for achievement of target blood pressure
(BP) below 140/90 mm Hg was used in the treatment of 99 patients with arterial
hypertension (AH) with (n=51) or without left ventricular (LV) hypertrophy
(LVH). At i... |
27,292 | [Peculiarities of hemostasis, metabolic activity of platelets, and rate of
aspirin resistance in patients with chronic heart failure after aorto-coronary
bypass surgery]. | Aim of the study was to investigate in dynamics peculiarities of hemostasis
including platelet aggregation and activity of NADP-dependent dehydrogenases in
platelets, as well as prevalence of resistance to aspirin in patients with
functional class II-III chronic heart failure (CHF). We determined parameters of
vasc... |
27,293 | [Characteristics of pharmacological and toxic effects of verapamil during
cardiac arrhythmia in thyrotoxic and hypothyroid rats]. | Aim of this study was to investigate antiarrhythmic and toxic effects of
verapamil in mice and rats with thyrotoxicosis and hypothyroidism. We found that
changes of thyroid status lead to the increased sensitivity of animals to
toxicity of verapamil. At single intraperitoneal introduction of verapamil, LD50
was 118... |
27,294 | [The problem of complications of percutaneous coronary interventions. Part III.
Optimal hemostasis]. | Successes in interventional cardioangiology allowed to widen area of application
of percutaneous interventions. After broadened anticoagulant and antiplatelet
therapy introducers are often withdrawn several hours after procedure. As a
consequence exended compression of puncture site is required. This results in
inc... |
27,295 | [Gamma-glytamiltransferase activity and cardiovascular diseases (ischemic heart
disease and cerebral stroke)]. | To investigate association between gamma-glytamiltransferase levels and the
development of CVD. The data were taken from materials of the epidemiological
study " Determinants of cardiovascular disease in Eastern Europe " , the HAPPIE
project. We investigated representative samples from non-organized population of
m... |
27,296 | [Possibilities of correction of coronary and myocardial reserves in patients
with ischemic heart disease by Angiotensin converting enzyme inhibitor
perindopril]. | AIM. Assessment of possibilities of correction of coronary and myocardial
reserves in patients with ischemic heart disease (IHD) by angiotensin converting
enzyme inhibitor perindopril included into combination antiischemic therapy.
MATERIAL AND METHODS: Antianginal and angioprotective effects of perindopril (8
mg/da... |
27,297 | [Comparative dynamics of markers of inflammation and NT-proBNP in different
variants of treatment of patients with ACS]. | STUDY AIM - assessment of dynamics of markers of inflammation (CRP, Il-6, Il-10,
TNFa, CD40L, fibrinogen) and N - N in acute coronary syndrome (ACS) as well as
analysis of effect of various methods of treatment on level of these parameters.
Patient aged 30 - 70 years were included in the study: 52 patients with ACS ... |
27,298 | [First results of open randomized clinical study of Acridilol in combination
therapy of patients with arterial hypertension and obesity or type 2 diabetes
(Mellitus-Open Multicenter Clinical Study ACCORD)]. | AIM: To study efficacy and safety of a preparation of carvedilol Acridilol
(Akrikhin, Russia) in patients with mild and moderate arterial hypertension (AH)
and obesity and/or compensated type 2 diabetes mellitus (DM).
MATERIAL AND METHODS: Patients (n=592) suffering from mild to moderate AH in
combination with DM an... |
27,299 | [Suppressive effect of recombinant immunomodulator ronkoleukin on the blood
level of antiinflammatory cytokines, anticardiolipin autoantibodies and heart
failure]. | AIM: To elucidate clinical efficacy and immunocorrecting properties of
recombinant immunomodulator ronkoleukin in patients with postinfarction cardiac
dysfunction with NYHA FC II-III CHF.
MATERIAL AND METHODS: In a 6-months prospective comparative clinically
controlled study we observed 33 survivors of myocardial in... |
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