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27,500 | [Remote clinical results of treatment of atrioventricular nodal reciprocated
with the use of novel and traditional methods of radiofrequency catheter
ablation of slow part pathway of atrioventricular junction]. | Remote results of radiofrequency catheter ablation (RFCA) - modification of
"slow" part pathway of atrioventricular junction (AVJ) in patients with typical
form of atrioventricular nodal reciprocal reciprocated tachycardia (AVNRT),
carried out on the basis bi and monopolar recording of electrical activity of
fibers... |
27,501 | [Profiles of genotypes of familial hypertrophic cardiomyopathy according to data
of clinical studies]. | With the aim of studying clinical profiles of hereditary cases of hypertrophic
cardiomyopathy (HCMP) we examined 64 patients with HCMP of both sexes (mean age
43.8+/-11.7 years). Genealogy of 40 patients (62.5%) revealed no cases of the
disease among first degree relatives. They were defined as sporadic forms of
HC... |
27,502 | [Possibility of the thermographic method for detection of ischemic myocardium]. | Thermography (TG) is used as a contact free method for investigation of the
myocardium ischemic injury. In coronary bypass surgery without artificial blood
circulation it is important to know how cessation of blood supply affects the
myocardium. In experiments on working heart, TG allows monitoring temperature at
t... |
27,503 | [Physical training with the use of electrostimulation of skeletal muscles in
cardiology]. | Conduction of programs of physical rehabilitation is impeded in most severely
ill cardiological patients. A method of training with the use of
electrostimulation of skeletal muscles (ESM) has been suggested recently for
this category of patients. This review contains detailed description of effects
of ESM in patien... |
27,504 | [The role of reduction of glomerular filtration rate in outcomes of drug-eluting
stents implantation in patients with ischemic heart disease and chronic kidney
disease]. | Patients (n=432) subjected to percutaneous coronary interventions (PCI) with
implantation of one or more drug eluting stents (DES) in 2005 were included in
this study. These patients were divided into 3 groups according to baseline
glomerular filtration rate (GFR): group 1 - GFR 60 ml/min/1.73 m2, n=271, group
2 - ... |
27,505 | [Independent diagnostic value of microalbuminuria and calculated glomerular
filtration rate in patients with arterial hypertension for detection of
subclinical renal involvement]. | In 734 patients with arterial hypertension without established diseases of
cardiovascular system (including 158 patients with diabetes mellitus) we
compared various methods of assessment of functional state of the kidney
(microalbuminuria, creatinine, calculation of creatinine clearance and
glomerular filtration ra... |
27,506 | [Function of endothelium and feto-utero-placental blood flow in pregnant women
with arterial hypertension]. | Aim of the study was to investigate function of endothelium and utero feto
placental blood flow in pregnant women with various degree of arterial
hypertension as well as effect of nifedipine SR/GITS and bisoprolol on arterial
pressure level, brachial artery endothelium dependent vasodilation (EDVD), level
of von Wi... |
27,507 | [Polymorphism of eNOS and iNOS Genes and Chronic Heart Failure in Patients With
Ischemic Heart Disease]. | URGENCY: Despite substantial progress in the treatment of coronary heart disease
(CHD) and chronic heart failure (CHF) prognosis in these conditions remains
extremely serious. This warrants their timely prevention and early detection.
Aim. To study influence of inducible NO synthase (iNOS) (CCTTT)n, Glu298Asp and
d... |
27,508 | [Changes of repolarization properties of the right ventricle in hypertensive
left ventricular hypertrophy]. | Repolarization properties of left ventricular (LV) myocardium change during its
hypertrophy of various genesis. Aim of this work was to study repolarization of
epicardial surface of the right ventricle (RV) in experimental model of LV
hypertrophy caused by renovascular hypertension in rats. We registered 32
unipola... |
27,509 | [Which of algorithms of warfarin dosing based on results of pharmacogenetic
testing is suitable for patients in Russia]. | Aim of the work was selection of optimal for patients in Russia algorithm of
warfarin dosing based on results of pharmacogenomic testing. We analyzed data
from 78 patients aged 63.4+/-9.4 years with known CYP29 and VKORC1 genotypes who
had participated in an earlier retrospective study in which they received
warfar... |
27,510 | [Contractility of the left ventricle of the human heart noninvasive measurement
in each cardiac cycle]. | History of development of the method of measurement of duration of the
preejection (DPE) period - characteristic of left ventricular (LV) contractility
is presented. On the basis of physiological prerequisites a novel computerized
method of DPE measurement in each consecutive cardiocycle has been created.
Distinct ... |
27,511 | [Persistent organic pollutants and atherosclerosis. Are there sufficient facts
to draw the ultimate conclusions]. | In recent years, there has been a growing number of scientific publications
examining the role of environmental factors, such as persistent organic
pollutants (POPs), in the development of atherosclerosis and atherosclerosis
associated diseases. POPs are synthetic lipophilic toxic compounds which are
resistant to d... |
27,512 | [Typical atrial flutter: classification, clinical manifestations, diagnosis, and
treatment]. | Main etiological factors, mechanisms of arrhythmogenesis and classification of
atrial flutter (AFl) are presented. Clinical electrocardiographical and
electrophysiological features of typical AFl are described. Main diagnostic
measures are delineated and principles of tactical approach to management of
patients wit... |
27,513 | [Contemporary approaches to nondrug correction of hypercholesterolemia]. | Hypercholesterolemia (HCE) together with arterial hypertension and smoking
belongs to three most powerful risk factors of cardiovascular diseases. Dietetic
correction of HCE includes limitation of consumption of animal fat containing
cholesterol, saturated and trans fatty acids, limitation of other cholesterol
cont... |
27,514 | [Antiplatelet therapy in coronary heart disease. Some problems and achivements]. | Standard double antiplatelet therapy (aspirin plus clopidogrel) used in patients
with coronary artery disease during acute coronary syndromes (ACS) and/or in
conjunction with percutaneous coronary interventions (PCI) has some limitations.
Relatively large proportion of patients has "laboratory" resistance to
clopid... |
27,515 | [Glycoprotein IIb-IIIa antagonist Monafram in primary angioplasty of patients
with acute coronary syndrome without st segment elevation]. | Glycoprotein (GP) llb-llla anagonist monafram is the F(ab)2 fragments of anti GP
llb llla monoclonal antibody FraMon (CRC64). Efficacy and safety of monafram in
primary coronary angioplasty of patients with acute coronary syndrome without ST
segment elevation (non ST ACS) was evaluated in this study. Monafram was
i... |
27,516 | [Analysis of morpho-functional parameters of the heart and polymorphisms of
Renin-Angiotensin-aldosterone system genes in patients with different variants
of the course of hypertrophic cardiomyopathy]. | BACKGROUND: Clinical course and prognosis of a hereditary myocardial disease
hypertrophic cardiomyopathy (HCMP) is determined by multiple factors most of
which have genetic nature.
AIM: To study morpho functional parameters of the heart and polymorphisms of
renin angiotensin aldosterone system genes in patients with... |
27,517 | [Clinical, hemodynamic and neurohumoral effects of switching patients with
chronic heart failure from not recommended -adrenoblockers to bisoprolol in
ambulatory practice]. | At present only bisoprolol, metoprolol succinate, nebivolol, and carvedilol are
considered to be beta adrenoblockers with proven efficacy relative to course and
prognosis of chronic heart failure (CHF). However in real clinical practice most
patients continue to receive preparations which are not recommended for
ap... |
27,518 | [Ischemic preconditioning and metabolism of myocardial adrenaline]. | We implanted under urethane narcosis microdialysis probes into myocardium of
Wistar rats. In experimental group we used ischemic preconditioning. After this
left descending coronary artery was occluded for 60 minutes and then reperfused
for 60 min. In control group prolonged occlusion was preceded by 30 min of rest.... |
27,519 | [Motor protein Kinesin-6 and ischemic heart disease]. | The review describes possible role of kinesins in development of coronary heart
disease and efficacy of treatment with statins. Fourty five kinesins are
represented in human body making up a superfamily of universal and simplest
motor proteins which are expressed almost in all tissues. Level of kinesin 6 is
5% high... |
27,520 | [Ischemic postconditioning of the heart. Receptor mechanisms and possibility of
clinical use]. | The authors of the review have analyzed papers published during last six years
on the problem of ischemic postconditioning of the heart. Postconditioning has
been shown to decrease infarct size, prevent apoptosis of cardiomyocytes,
improve cardiac contractility in reperfusion period, prevent appearance of
reperfusi... |
27,521 | [Cistatin C as a novel marker of renal function impairement and cardiovascular
risk]. | Impairment of renal function beginning from subclinical stages is independent
risk factor of development of cardiovascular diseases and cardiovascular death.
Cystatin C is considered in recent years as an alternative marker of functional
state of the kidney and risk of development of cardiovascular diseases. Cystati... |
27,522 | [Contemporary concepts of the role of inflammation in atherosclerosis]. | We present in this article main theories of development of atherosclerosis and
modern views of the role of inflammation in atherogenesis. We have conducted a
review of studies of the role of endothelial local factors such as accumulation
of smooth muscle cells, T and B lymphocytes, macrophages, matrix
metalloprotei... |
27,523 | [The RECORD registry. Treatment of patients with acute coronary syndromes in
hospitals with and without possibilities to perform invasive coronary
procedures]. | The participants initiated RECORD registry in Russia recruited 796 patients
(pts) with ST elevation (STE, n=256) and non ST elevation (NSTE, n=550) acute
coronary syndrome (ACS) between 11.2007 and 02.2008. Ten of 18 participating
hospitals (H) had facilities for coronary angiography and revascularization
(invasive... |
27,524 | [Predictors of coronary adverse events in patients with acute coronary syndrome
with ST segment elevation treated with percutaneous coronary interventions with
stenting]. | OBJECTIVE: The aim of this 12 months observational study was to investigate risk
factors of major adverse coronary events, such as death or Q wave myocardial
infarction due to stent thrombosis or in stent restenosis.
MATERIAL AND METHODS: One hundred fifty four patients with ST segment elevation
acute coronary syndr... |
27,525 | [Cardiorenal interrelationships in elderly patients with arterial hypertension]. | AIM: To study clinico functional characteristics of the kidney and
cardiovascular system in elderly patients with arterial hypertension (AH) in
comparison with corresponding data from young and middle age patients with AH.
MATERIAL AND METHODS: We examined 142 patients with AH (110 patients aged 60
years and 32 pati... |
27,526 | [The role of modification of fatty acid composition of erythrocyte lipids in
pathogenesis of arterial hypertension]. | We used liquid chromatography for analysis of fatty acids (FA) in lipids of
erythrocytes of patients with hypertensive disease (HD) with normo- (group 1)
and hyperlipidemia (group 2). Abnormalities of FA composition of erythrocyte
lipids were revealed in both groups. In group 1 we found deficit of polyenic
acids of... |
27,527 | [Atrial fibrillation in patients with type 2 diabetes mellitus: specific
features of development and antirecurrence therapy]. | We examined 212 patients aged 52-70 years with persistent symptomatic atrial
fibrillation (AF). Comparison of AF substrates in patients with (n=26) and
without (n=27) type 2 diabetes mellitus (DM2) revealed slowing of intraatrial
conduction, increased vulnerability of atria, and more pronounced worsening of
left ve... |
27,528 | [Some special characteristics of vascular reactivity in heart failure]. | We determined parameters of elasticity of peripheral arteries in patients with
heart failure (HF) including those with pulmonary arterial hypertension. We also
investigated pulmonary artery responses to vasoconstricting factors in vitro.
Reactivity of the aorta and carotid artery was studied on the model of
experim... |
27,529 | [Risk of cardiovascular death and social status in the Tumen cohort: results 12
years prospective study]. | In an open Tumen population we assessed associations of relative risk (RR) of
death of cardiovascular diseases with characteristics of social status: level of
education, occupation, and marital status. Risk of cardiovascular death in
female and male population was the highest among persons with low level of
educati... |
27,530 | [Ionic mechanisms of action of class III antiarrhythmic drugs]. | In this review we discuss mechanisms of antiarrhythmic and adverse proarrhythmic
action of class III drugs. Special attention is given to ionic currents and
channels which determine specific features of their effects (IKr, IKa, IKur). We
consider general patterns of changes of bioelectrical activity in atria and
ve... |
27,531 | [Percutaneous coronary interventions in patients with acute myocardial
infarction after successful thrombolysis]. | In 259 patients with acute myocardial infarction admitted to N.V. Sklifosofsky
Institute of Urgent Aid in 2003-20007 we compared efficacy of 3 strategies of
treatment after successful thrombolytic therapy (TLT): percutaneous coronary
intervention (PCI) because of recurrent ischemia within 5 days after
thrombolytic ... |
27,532 | [Possibilities of correction of rheological properties of the blood and free
radical processess in patients with acute myocardial infarction combined with
type 2 diabetes mellitus]. | Aim of the study was assessment of rheological parameters of the blood and
processes of free radical oxidation as well as rate of arrhythmia development in
patients with acute myocardial infarction (AMI) and type 2 diabetes mellitus
(DM) whose otherwise standard therapy was supplemented with 90% omega-3
polyunsatur... |
27,533 | [Genetic predisposition to development of atrial fibrillation in patients with
hypertensive disease]. | We studied associations of genes of adrenoreceptor types 1, 2 and 3 (ADRB1,
ADRB2, ADRB3), connexin (CX40) and voltage gated potassium channel type 2
(KCNH2) with development of atrial fibrillation (AF) in patients with
hypertensive disease. We examined 102 patients with hypertensive disease which
in 51 was complic... |
27,534 | [Effect of atorvastatin on hemorheological parameters in patients with arterial
hypertension with dyslipidemia]. | We assessed effect of 6-weeks therapy with atorvastatin on parameters of lipid
metabolism and some hemorheological characteristics in 27 patients with arterial
hypertension (AH) and dyslipoproteinemia (DLP). In addition to general clinical
examination we studied hemorheological profile including hematocrit, blood
p... |
27,535 | [Dynamics of structural-functional parameters of cardiovascular system during
use of complex therapy of women with type 2 diabetes mellitus]. | Aim of the work was to study dynamics of parameters of cardiovascular system in
women during use of various sugar lowering drugs in complex multifactorial
therapy of type 2 diabetes mellitus (DM). We included in this 12 months study
182 women older than 55 years with type 2 DM, abdominal obesity and artrerial
hyper... |
27,536 | [Lipid lowering, antiinflammatory, and vasoprotective effects of fenofibrate in
patients with type 2 diabetes mellitus]. | Aim of the study was to assess effect of fenofibrate on lipid blood composition,
markers of inflammation and the state of vascular wall in patients with type 2
diabetes mellitus (DB2). We randomized 73 patients with DB2 in 2 groups.
Patients of group one (n = 34) in addition to hypoglycemic and lipid lowering
thera... |
27,537 | [Anticoagulant action and safety of warfarin dosing based on pharmacogenetic
testing: results of the first Russian prospective pilot study]. | Aim of the study was to compare numbers of episodes of excess hypocoagulation
and bleeding with warfarin dosing based on pharmacogenetic testing and
traditional method in patients with high risk of thromboembolic complications.
In 76 patients (43 men and 33 women aged 60.3 +/- 12.3 years) warfarin was
administered ... |
27,538 | [Value of endothelial dysfunction in cardiovascular diseases and methods of its
correction with drugs]. | Vascular endothelium is not simply a barrier between blood and extra vascular
bed but is a source of large number of mediators regulating various functions of
the body among which nitrous oxide appears to be one of most important.
Endothelial dysfunction (ED) develops in a number of processes: diabetes
mellitus, sm... |
27,539 | [Thienopyridines in the treatment and prevention of cardiovascular diseases.
Part V. Combination of clopidogrel and acetylsalicylic acid in the treatment of
stable patients with atherothrombotic cardiovascular diseases]. | In a series of articles the authors consider clinical pharmacology and
experience of clinical application of blockers of platelet P2Y12 receptors, most
well known representatives of which ticlopidine and clopidogrel according to
chemical structure belong to thienopyridine derivatives. In the fifth
communication we ... |
27,540 | [Atrioventricular nodal reciprocal tachycardia: classification, clinical
manifestations, diagnosis, and treatment]. | Data on prevalence, mechanisms of arrhythmogenesis and classification of
atrioventricular (AV) nodal reciprocal tachycardia are presented.
Clinical-electrocardiographical and electrophysiological features of typical and
atypical forms of AV nodal reciprocal tachycardia are described. Main diagnostic
measures are de... |
27,541 | [Polymorphism C1444T of C-reactive protein gene and C-reactive protein
concentration in blood serum of healthy people and patients with myocardial
infarction]. | CRP level is a risk factor of development of ischemic heart disease (IHD) and
acute myocardial infarction (MI) in healthy people, while in patients with
cardiovascular diseases it is a marker of unfavorable prognosis. It has been
shown in recent investigations that individual variations of plasma CRP levels
to a gr... |
27,542 | [Assessment of the state of atrial myocardium by two-dimensional grey-scale
deformation in patients with arterial hypertension and mild left ventricular
hypertrophy]. | Non-Doppler two-dimensional grey-scale deformation (TGD) is a novel method of
assessment of deformation and velocity of deformation of myocardium. TGD allows
to evaluate regional and global mechanical function of atria. Aim of our work
was to study longitudinal deformation and deformation velocity of the left
atriu... |
27,543 | [An experience of the use of angiotensin II receptor blocker losartan in
patients with metabolic syndrome and chronic kidney disease]. | Aim of the study--to assess efficacy and safety of one of angiotensin II
receptor blockers in patients with metabolic syndrome (MS) and I-V stage chronic
kidney disease. We studied cardiodynamic and renal effects of losartan in
average daily dose 50 +/- 13.06 mg in 20 patients (9 men and 11 women aged 32-79
years) ... |
27,544 | [Assessment of risk of cardiovascular diseases in persons of young age]. | Cardiovascular pathology appears to be big socially meaningful problem as it
occupies leading place in structure of mortality and loss of working capacity in
economically developed countries. Social value of the problem is enforced by
observed in recent years tendency to increase of mortality of cardiovascular
dise... |
27,545 | [Anomalies of coronary arteries]. | Concealed undiagnosed congenital anomalies of coronary arteries (CACA) can cause
sudden death of young men. Isolated CACA are detected at 0.6-1.8% of coronary
angiographies. Classification of CACA (2002) includes anomalous origin of
coronary artery from pulmonary artery, anomalous origin of coronary artery from
the... |
27,546 | [Effect of polymorphisms of cytochrome P450 and apolipoprotein E genes on
therapeutic efficacy of statins]. | Statins are widely used in clinical practice for lowering of levels of
atherogenic blood plasma lipids and treatment of atherosclerosis. Variability of
response of the body to these drugs might be determined by genetic factors (gene
polymorphisms) related to metabolism of drugs. Among them central place belongs
to ... |
27,547 | [The program of lowering of residual risk (the residual risk reduction
initiative). Part I. Factors of residual risk]. | Substantial residual risk of development of macro- and microvascular
complications is retained in most patients despite contemporary standards of
therapy. The search for the solution of actual problem of lowering of residual
risk of vascular complications is the aim of multiple current scientific studies
conducted ... |
27,548 | [Rational management of atrial fibrillation in intensive care]. | Atrial fibrillation (AF) occurs frequently in intensive care unit (ICU) patients
and after coronary bypass graft (CABG) and valve surgery, with the peak
incidence on postoperative days 2 and 3. Moreover, AF is one of the most common
complications after thoracic surgery, e.g. video-assisted thoracic surgery
(VATS), ... |
27,549 | [Clinical-pharmacoeconomical aspects of ß-adrenoblockers use in patients with
ischemic heart disease undergoing coronary artery bypass grafting]. | Aim of this study was to assess clinical and pharmacoeconomic effects of long
term use of adrenoblockers in patients with ischemic heart disease (IHD)
undergoing coronary artery bypass grafting. Patients with IHD (n=294) were
included in open, prospective, randomized clinical trial. The follow up period
was 3 years... |
27,550 | [Waist circumference below metabolic syndrome harmonizing criteria is associated
with increased cardiovascular risk]. | AIM: To test the hypothesis that waist circumference (WC) just below Joint
Interim Statement ([JIS], 2009) abdominal obesity thresholds can be associated
with worse risk factors profile than smaller WC.
METHODS: In a study of risk factors in families of patients with "premature"
coronary heart disease (CHD) we exami... |
27,551 | [Parameters of central hemodynamics in patients with paroxysmal atrioventricular
nodal reciprocal tachycardia before and after radiofrequency catheter ablation]. | We present in this article results of assessment of morphofunctional state of
the myocardium in patients with typical form of paroxysmal atrioventricular
nodal reciprocal tachycardia (AVNRT) before and during one year after
radiofrequency catheter ablation of slow part of atrioventricular junction and
their compari... |
27,552 | [Dynamics of structural functional parameters of cardiovascular system in
patients with Stable Angina and Congestive Heart Failure treated with Ivabradine
for six months]. | URGENCY: Frequency of warm reductions (FWR) is the independent risk factor
increasing frequency of the general death rate, sudden death rate and death rate
from cardiovascular diseases. Aim of the work was to study dynamics of
parameters of cardiovascular system in Patients with Stable Angina (SA) and
Congestive He... |
27,553 | [Echocardiographical evaluation of mean pulmonary artery pressure in patients
with chronic obstructive pulmonary disease]. | We compared Dopplerographic methods and invasive assessment of mean pulmonary
artery pressure (MPAP) in 20 men with chronic obstructive pulmonary disease
(COPD). We demonstrated possibility of evaluation of mean pulmonary artery
pressure by Doppler methods of calculation using diastolic gradient of pressure
of pulm... |
27,554 | [Salt sensitivity in patients with arterial hypertension]. | We present literature review on the role of excessive sodium consumption with
food in pathogenesis of salt sensitive arterial hypertension (AH) as well as
scientific data allowing to consider sensitivity to salt as independent factor
of development and unfavorable course of AH associated with insulin resistance,
hi... |
27,555 | [A scale for early assessment of risk of death and myocardial infarction during
initial hospitalization of patients with acute coronary syndromes (based on data
from the RECORD registry)]. | Independent predictors of death and death or myocardial infarction (MI) during
initial hospitalization of patients with acute coronary syndromes (ACS) were
determined using database of Russian independent ACS registry RECORD. These
predictors (admission Killip class II, ST-segment elevation 1 mm, systolic blood
pre... |
27,556 | [Inhospital and 12-months results of percutaneous coronary interventions with
implantation of Paclitaxel eluting stents in patients with long de novo coronary
artery lesions]. | We implanted 59 paclitaxel eluting Apollo stents to 48 patients with ischemic
heart disease (IHD) and long de novo coronary artery lesions in 2007 with 100%
immediate success rate without inhospital major cardiac complications. One
patient developed hematoma at femoral artery puncture site. There were no cases
of r... |
27,557 | [The efficacy and safety of the combination of β-blocker bisoprolol and if
inhibitor I(f) ivabradine in patients with stable angina and chronic obstructive
pulmonary disease]. | The study was aimed to assess the efficacy and safety of treating coronary heart
disease (CHD) patients complicated with COPD using the combination of tolerable
doses of -blocker bisoprolol and inhibitor If-channel ivabradine, compared with
bisoprolol alone. A total of 50 patients were included (88% men, mean age
6... |
27,558 | [The use of a short program of physical training in patients with ischemic heart
disease after endovascular (coronary) interventions in complex program of
rehabilitation and secondary prevention at dispensary-ambulatory stage]. | Aim of the study was to assess efficacy of a short program of medium intensity
physical training of patients with ischemic heart disease (IHD) after
endovascular intervention (EVI) in conditions of practical health care of
Russia. Patients (n=100) were randomized into 2 groups - intervention (main
group "M", n=50) ... |
27,559 | [Comparative eficacy of antihypertensive therapy in patients with arterial
hypertension and various sensitivity to salt]. | In 102 patients with high risk (52 patients with history of myocardial
infarction, 50 patients with history of cerebral stroke within previous 6-48
months) arterial hypertension (AH) we studied clinical efficacy on angiotensin
converting enzyme inhibitor (ACEI) lisinopril, calcium antagonist felodipine,
and nonsele... |
27,560 | [Possibilities of the use of parenteral form of α- and β-adrenoblocker for the
treatment of hypertensive crises at prehospital stage]. | Butylaminohydroxypropoxyphenoxymethyl methyloxadiazole was used in prehospital
treatment of 40 patients (15 women, 25 men aged 63+/-17.1 years) with
complicated hypertensive crises (HC) characterized by acute involvement or high
risk of progression of damage of internal organs. The drug was administered as
intraven... |
27,561 | [Effects of exogenous apelin-12 on functional and metabolic recovery of isolated
rat heart after ischemia]. | Apelin 12 (A 12) was synthesized by the automatic solid phase method with the
use of Fmoc technology. The synthesized peptide was purified by preparative HPLC
and identified by 1H NMR spectroscopy and mass spectrometry. Effects of A 12
were studied on isolated working rat hearts perfused with Krebs buffer (KB)
cont... |
27,562 | [Inflammation and atherosclerosis: the role of Renin-Angiotensin system and its
inhibition]. | The last studies show the renin angiotensin aldosterone system plays an
important role in atherosclerotic processes. Vasoconstriction and sodium and
water retention, due to angiotensin II and aldosterone promote atherosclerotic
processes. Theres recent evidence from animal and clinical studies to consider
angiotens... |
27,563 | [Behavioral type d personality (distressor) in cardiovascular diseases]. | Psychosocial stress is acknowledged as one of risk factors of development of
cardiovascular pathology. Type D personality (distressor) comprises negative
excitability (tendency to experience negative emotions) and social inhibition
(suppression of emotions and behavioral reactions in social interactions). In
this r... |
27,564 | [Statins as Anti-Inflammatory Agents]. | Statins modify cellular composition of atherosclerotic plaques decreasing their
inflammatory elements capable to produce plaque destabilizing metalloproteinases
and prothrombotic tissue factor. In humans long term administration of these
drugs leads to decrease of levels of markers of inflammation notably of
C-reac... |
27,565 | [Results of 6-Month Follow-up of Patients With Non-ST-Elevation Acute Coronary
Syndrome Treated With Enoxaparin. Data of Multicenter Study in Russia]. | Two hundred eighty four patients aged 30-85 (mean 62-/+10.2) years hospitalized
because of prolonged attack of rest angina were included into open
noncomparative study of enoxaparin tolerability. In addition to conventional
aspirin the patients received enoxaparin (1 mg or 100 anti-Xa U/kg
subcutaneously) every 12 ... |
27,566 | [Possibilities of Surface ECG Mapping in Diagnosis of Ischemic Heart Disease in
Patients With Aortic Stenosis]. | Method of surface ECG mapping and graded bicycle exercise test were used for
noninvasive detection of coronary artery involvement in 24 patients with aortic
stenosis. The actual presence of coronary artery disease was verified by
coronary angiography. Isointegral ST-segment maps were constructed and analyzed.
Stepw... |
27,567 | [Morpho-Functional Changes of Thoracic Aorta in Atherosclerosis: Multiplane
Transesophageal Ultrasound Study]. | AIM: To elucidate possibilities of multiplane transesophageal ultrasound for
assessment of localization and structure of atherosclerotic plaques in the
thoracic aorta as well as relationship between changes of elastic-tonic
properties, processes of aortic wall remodeling, stage of aortic atheromatosis,
and coronary... |
27,568 | [Multicenter Study of Efficacy and Safety of a Preparation of Lovastatin in
Patients With Ischemic Heart Disease and Mild or Moderate Hypercholesterolemia]. | Ninety patients with ischemic heart disease and mild or moderate
hypercholesterolemia were included in a multicenter study of efficacy and safety
of a preparation of lovastatin (Holetar, KRKA). After 6 weeks of a diet period
46 patients remained on diet and in 44 patients lovastatin was added to diet for
12 weeks. ... |
27,569 | [Immediate and Remote Results of Endovascular Recanalization of Chronic Coronary
Artery Occlusions]. | We compared early and long-term follow-up results of balloon angioplasty and
stenting of chronic coronary occlusions. The initial success rate was 75% (82 of
109 patients). Proportion of patients free of angina was 57 and 69% after
successful balloon angioplasty and stenting, respectively. Stenting of coronary
occl... |
27,570 | [Calcium 2+ Response of Lymphocytes to Standard Test-Substances in Patients With
Ischemic Heart Disease and Heart Failure]. | Changes of [Ca 2+]i were studied in peripheral blood lymphocytes of patients
with ischemic heart disease and heart failure. Basal [Ca 2+]i and its changes
under action of mitogenes (PHA, Con A; 10 mcg/ml), butylhydroxyquinone (BHQ;
9-14 mcM) and arachidonic acid (3-10 mc/M) were measured. Patients with heart
failur... |
27,571 | [Modification of clinical classification of heart failure with quantitative
evaluation of functional state]. | Definite dissociation exists between severity of clinical symptoms of heart
failure and degree of cardiac dysfunction. Comparative analysis of existing
heart failure classifications reveals low degree of congruence in evaluation of
patient's state by different experts. This disagreement is mainly caused by
limited ... |
27,572 | [Treadmill stress-echocardiography in diagnosis of coronary artery involvement
in patients with various probability of ischemic heart disease]. | Results of treadmill stress-echocardiography were compared with those of
coronary angiography in 153 patients (133 men, 20 women, mean age 55.7-/+8.5
years) with various initial probability of ischemic heart disease (IHD) which
was determined for each patient basing on sex, age and status of angina.
Probabilities o... |
27,573 | [Changes of autologous coronary vessels and aortocoronary grafts in patients
with ischemic heart disease after coronary artery bypass grafting]. | AIM: 1) to assess effect of coronary lesion morphology on changes of grafts
during first year after surgery; 2) to study the state of native coronary
vascular bed during first year after surgery; 3) to elucidate special features
of atherosclerosis in grafts and coronary arteries in remote period after
surgery.
MATE... |
27,574 | [Simvastatin (40 mg/day) in patients with hereditary hypercholesterolemia:
effect on high density lipoprotein cholesterol]. | AIM: To study effect of simvastatin of the level of high density lipoprotein
(HDL) cholesterol (CH).
MATERIAL AND METHODS: Simvastatin (40 mg/day) was given for 3 months to 15
patients (3 men, 12 women, mean age 56-/+10.3 years) with hereditary type II
hypercholesterolemia after washout from lipid lowering therapy. ... |
27,575 | [Prolonged pulmonary artery pressure monitoring in patients with pulmonary
hypertension]. | Pulmonary artery pressure (PAP) was monitored for 24-48 hours in 10 and 8
patients with primary and secondary pulmonary hypertension, respectively. The
data obtained were compared with results of prolonged PAP monitoring in 2
healthy volunteers. Variability of mean PAP was 7.43-/+3.1, 5.78-/+1.64, and
3.4-/+0.63 mm... |
27,576 | [Decreased ATP-synthesis ability of liver mitochondria in spontaneously
hypertensive rats (SHR): role of calcium overload of the mitochondria]. | It has been shown previously, that a decrease of ATP amount and changed balance
of the other macroergic phosphates are observed in different tissues of
spontaneously hypertensive rats (SHR) compared with the normotensive controls
(WKY). The aim of the present study was to assess the ability of SHR liver
isolated mi... |
27,577 | [The protective action of ubiquinone at ischemia and reperfusion]. | Effects of prolonged consumption of ubiquinone on myocardial injury caused by
ischemia and reperfusion were studied in reperfused rat hearts. Wistar rats
received lipophylic or hydrophilic forms of ubiquinone for 6-8 weeks with chow
or water, respectively. Isolated isovolumic hearts with a constant volume latex
bal... |
27,578 | [Fungal myocarditis in deep visceral candidiasis]. | Morphological and functional changes of the myocardium were studied in 40
patients with candidiasis and attempt to establish morphological criteria of
fungal myocarditis was undertaken. Retrospective analysis of autopsy material
showed that myocardial involvement in candidiasis was possible and was not as
rare as i... |
27,579 | [Third generation of calcium antagonists: focus on lacidipine]. | Similarities and dissimilarities of 3 third generation calcium antagonist
(amlodipine, lacidipine and lercanidipine) are presented. Lacidipine is
characterized by prolonged antihypertensive action despite its plasma half life
is just about 14 hours. Duration of lacidipine effect can be explained by
accumulation in ... |
27,580 | [Metabolic syndrome from the point of view of a cardiologist: diagnosis, non
drug and drug treatment]. | Timely diagnosis and treatment of metabolic syndrome is important because of
high prevalence of this pathology in population. For the elaboration of
approaches to complex treatment of this syndrome it is necessary to understand
pathogenetic mechanisms of development of hypertension and metabolic changes as
well as ... |
27,581 | [The role of mast cell population in aortic intima in development of human
atherosclerosis]. | AIM: To assess the role of mast cells in development of human atherosclerosis.
MATERIAL: Autopsy material (transverse cross-sections of the aorta and
membranous preparations of intima) from 53 persons who died of accidental
causes. Original method of the study of aortic cellular populations on
membranous preparation... |
27,582 | [Prognostic significance of treadmill stress-echocardiography in patients with
ischemic heart disease]. | Prognostic value of treadmill echocardiography was studied in 146 patients (125
men, 21 women, age 58,6-/+9 years) with overt or suspected ischemic heart
disease. During 35-/+6 months of follow-up there were 26 cardiac events (11
cardiovascular deaths, 6 myocardial infarctions and 9 revascularization
procedures). I... |
27,583 | [Postinfarction angina in elderly patients: results of surgical and drug
treatment]. | Clinical and angiographical characteristics and results of surgical treatment
and drug therapy were assessed in 49 men with postinfarction angina (mean age
64.1-/+3.5 years) and 112 patients with progressing and stable angina (mean age
63.8-/+3.0 years). Of 49 patients with postinfarction angina 30 were subjected
t... |
27,584 | [Doppler echocardiographic assessment of hemodynamic parameters on patients with
tetralogy of Fallot]. | Continuous Doppler echocardiography was used for the study of hemodynamic
parameters on various stages of treatment of 61 children (mean age 12.4 months)
with tetralogy of Fallot. Twenty five patients were studied before surgery
during spells of cyanosis and hyperpnea. Thirty six patients were treated with
systemic... |
27,585 | [Stability of diurnal blood pressure rhythm during 48-hour ambulatory blood
pressure monitoring]. | Evaluation of nocturnal blood pressure (BP) fall is important for prognosis and
selection of antihypertensive therapy. We assessed stability of BP diurnal
rhythm in 56 hospitalized hypertensive patients by means of 48-hour ambulatory
BP monitoring. According to the degree of congruence of BP fall during two
nights ... |
27,586 | [Pathogenetic role of moxonidine in the treatment of hypertension in
postmenopausal women]. | AIM: To assess efficacy of monotherapy with moxonidine in female patients with
hypertension and climacteric syndrome.
METHOD: Twenty-four hour blood pressure monitoring was carried out in 32 women
(mean age 52.3-/+5.2 years) before and after 28 days of monotherapy with
moxonidine (0.2-0.4 mg).
RESULTS: In 4 weeks th... |
27,587 | [Assessment of safety and antihypertensive efficacy of a cardioselective
beta-blocker nebivolol in patients with hypertension and concomitant chronic
obstructive bronchitis]. | Safety, tolerability and antihypertensive efficacy of a cardioselective
beta-blocker nebivolol was studied in 30 patients with mild and moderate
hypertension and concomitant stage I chronic obstructive bronchitis. Nebivolol
(5 mg/day) was given for 1 month; in 5 patients complementary
hydrochlorothiazide (12.5 mg/d... |
27,588 | [Angiotensin-converting enzyme gene polymorphism in patients with primary
disturbances of cardiac conduction]. | Increased frequencies of angiotensin-converting enzyme (ACE) D-allele and
ID-genotype among patients with idiopathic atrioventricular blocks and I allele
and II genotype among patients with idiopathic intraventricular blocks allow to
consider these genotypes risk factors of corresponding disturbances of cardiac
con... |
27,589 | [Angiotensin converting enzyme inhibitor enalapril in the treatment of
endomyocardial fibrosis in patients with lymphogranulomatosis subjected to
radio- and chemotherapy]. | Echocardiography was used in the study of 40 patients with stage IIA-IVB
lymphogranulomatosis. In 2-6 years before the study all patients had been
treated with combination radio- (36-44 Gy) and chemotherapy. Echocardiography
revealed endomyocardial fibrosis and signs of cardiac remodeling (reduced left
ventricular ... |
27,590 | [Myocardial mass and geometry in population study of women in Tallinn
(echocardiography data)]. | In a framework of a population study in Tallinn triple blood pressure
measurements, electro- and echocardiography were carried out in 398 women (82.6%
of all participants) aged 35-59. Left ventricular hypertrophy (left ventricular
mass >or=198 g, left ventricular mass/height ratio >or=121 g/m, left ventricular
mass... |
27,591 | [Isoproterenol induced changes of protein expression and myocardial
ultrastructure]. | AIM: To elucidate alterations in myocardial ultrastructure and protein
expression caused by isoproterenol.
METHODS: Biochemical, immunohistochemical and electron microscopic studies of
rat myocardium were carried out 2 hours and 3 weeks after single injections of
isoproterenol (50 and 10 mg/kg). Relative content of ... |
27,592 | [Coronary angioplasty with direct stenting: assessment of primary results and
some economical aspects]. | Comparison of immediate angiographical and clinical results of direct coronary
stenting and stenting after predilation was carried out in 68 patients. Groups
of patients subjected to direct stenting and stenting with predilation had
similar clinical and angiographical characteristics. Direct stenting was
successful... |
27,593 | [Postoperative spasm of mammary-coronary grafts and possibilities of its
correction by dihydropyridine calcium antagonists nifedipine and amlodipine]. | AIM: To assess efficacy of dihydropyridine calcium antagonists nifedipine and
amlodipine for prevention of spasm of internal mammary artery after
mammary-coronary bypass grafting.
MATERIAL AND METHODS: Eighty eight men (age 56,5-/+7.2 years) subjected to
mammary-coronary grafting were randomized to 3 groups. Patient... |
27,594 | [Left ventricular hypertrophy does not affect diagnostic accuracy of treadmill
stress echocardiography in patients with normal left ventricular contractility
at rest]. | Results of exercise echocardiography (treadmill) and of coronary angiography
were compared in 119 subjects (mean age 54.9-/+7.9 years) with normal left
ventricular contractility at rest. Forty two patients had no pronounced lesions
in coronary arteries, while 77 had >50% stenoses in main coronary arteries.
Sensitiv... |
27,595 | [Use of selective long-acting beta-blocker with vasodilating activity celiprolol
in patients with essential hypertension]. | Effects of 8 weeks therapy with long-acting selective b-blocker celiprolol (200
mg o.d.) on 24-hour blood pressure, central hemodynamics (oscillometry) and
microcirculation (laser doppler flowmetry) were studied in 30 patients (17 women
and 13 men, mean age 51.9 years), with stage I-II essential hypertension.
Celip... |
27,596 | [Effect of nebivolol on remodeling of the heart and vessels and the state of
hemodynamics in patients with hypertension]. | Echocardiography, doppler echocardiography and venous occlusion plethysmography
were used for the study of effects of monotherapy with nebivolol (2.5-10, mean
5.1 mg/day for 24 weeks) on remodeling of cardiovascular system and the state of
hemodynamics in 25 patients with stage II hypertension and chronic heart fail... |
27,597 | [Hypertension--main risk factor of stroke. Results of a three years register in
Krasnodar]. | Incidence of first stroke and stroke mortality in Krasnodar in 1997-2000 were
higher compared with data of similar registers in Moskva and Novosibirsk.
Hospitalization rate of patients with stroke especially of those with severe
stroke was low with high 28 days and 1 year mortality. Main risk factor of
stroke was h... |
27,598 | [Effect of eprosartan on left ventricular diastolic function and cerebral
hemodynamics in patients with hypertension]. | Eprosartan (600-1200 mg/day) was given for 4 weeks to 28 patients aged 32-62
years with stage II-III hypertension (WHO, 1999). Left ventricular diastolic
function and cerebral blood flow were assessed by echocardiography and
ultrasound dopplerography. Treatment with eprosartan was associated with
improvements of im... |
27,599 | [Prevalence of excessive body mass and its relation to mortality from
cardiovascular and main chronic noninfectious diseases among urban male
population of geographical different regions in Russia]. | The paper contains data on prevalence of low, normal, excessive body mass and
obesity among urban male populations aged 20-54 years in different regions.
Relative risk of death associated with body mass was estimated on the basis of a
twenty years prospective study of sample populations in Moskva and St-Peterburg
a... |
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