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3,700
Amiodarone for ACLS: a critical evaluation.
Years ago, William Osler taught physicians, "Be not the first nor the last to adopt a therapy." This continues to be sage advice. Clinicians should be cautious in considering the use of amiodarone in a field setting for cardiac arrest until studies clearly show a benefit over drugs currently in use. The endpoint of the...
3,701
Arrhythmias after pediatric lung transplantation.
Atrial arrhythmias have been reported after congenital heart surgery involving extensive atrial suture lines. Experimental studies involving bilateral lung transplantation (Tx) suggest that the left atrial suture lines predispose to atrial flutter. The overall incidence and type of arrhythmias after pediatric lung Tx h...
3,702
Ischemic and anesthetic preconditioning reduces cytosolic [Ca2+] and improves Ca(2+) responses in intact hearts.
Ca(+) loading during reperfusion after myocardial ischemia is linked to reduced cardiac function. Like ischemic preconditioning (IPC), a volatile anesthetic given briefly before ischemia can reduce reperfusion injury. We determined whether IPC and sevoflurane preconditioning (SPC) before ischemia equivalently improve m...
3,703
Selective AV nodal vagal stimulation improves hemodynamics during acute atrial fibrillation in dogs.
Although the atrioventricular node (AVN) plays a vital role in blocking many of the atrial impulses from reaching the ventricles during atrial fibrillation (AF), a rapid irregular ventricular rate nevertheless persists. The goals of the present study were to explore the feasibility of novel epicardial selective vagal n...
3,704
Structural remodelling during chronic atrial fibrillation: act of programmed cell survival.
Atrial fibrillation is the most common cardiac arrhythmia with an overall prevalence of almost 1%. Increasing prevalence and associated risks such as stroke and mortality have increased the need for better and more reliable therapeutic treatment. This has stimulated research to elucidate the pathophysiological mechanis...
3,705
Adverse cardiac events after surgery: assessing risk in a veteran population.
To establish rates of and risk factors for cardiac complications after noncardiac surgery in veterans.</AbstractText>Prospective cohort study.</AbstractText>A large urban veterans affairs hospital.</AbstractText>One thousand patients with known or suspected cardiac problems undergoing 1,121 noncardiac procedures.</Abst...
3,706
Alcohol and the heart.
ALCOHOLISM IN GENERAL: Alcoholism is one of the major health problems in the world. Alcohol consumption has an impact on different body systems like the central nervous system, the gastrointestinal tract, the hematopoetic organs, and the cardiovascular system. Alcohol interferes with other medications, and drinking can...
3,707
Commodio cordis: an underappreciated cause of sudden cardiac death in young patients: assessment and management in the ED.
Commotio cordis is the condition of sudden cardiac death or near sudden cardiac death after blunt, low-impact chest wall trauma in the absence of structural cardiac abnormality. Ventricular fibrillation is the most commonly reported induced arrhythmia in commotio cordis. Blunt impact injury to the chest with a baseball...
3,708
A comparison of biphasic and monophasic waveform defibrillation after prolonged ventricular fibrillation.
To compare the effects of biphasic defibrillation waveforms and conventional monophasic defibrillation waveforms on the success of initial defibrillation, postresuscitation myocardial function, and duration of survival after prolonged duration of untreated ventricular fibrillation (VF), including the effects of epineph...
3,709
Survival from out-of-hospital cardiac arrest in the Geelong region of Victoria, Australia.
To study the outcome from prehospital cardiac arrest managed by ambulance personnel, and to examine overall survival rates from successful resuscitation.</AbstractText>A retrospective analysis was made of 115 patient care records of prehospital cardiac arrests with attempted resuscitation between July 1996 and Septembe...
3,710
Mechanism of ventricular defibrillation for near-defibrillation threshold shocks: a whole-heart optical mapping study in swine.
To study the mechanism by which shocks succeed (SDF) or fail (FDF) to defibrillate, global cardiac activation and recovery and their relationship to defibrillation outcome were investigated for shock strengths with approximately equal SDF and FDF outcomes (DFT(50)).</AbstractText>In 6 isolated pig hearts, dual-camera v...
3,711
The role of prostaglandins in the antiarrhythmic effect of ischemic preconditioning.
The role of prostaglandins in the antiarrhythmic effect of ischemic preconditioning (IP) was investigated in pentobarbital-anesthetized rats. In 5 unpreconditioned control rats, 30 min of occlusion of the left coronary artery elicited ventricular tachycardia (VT) and fibrillation (VF), with an average duration of VT an...
3,712
Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection.
Ischemic preconditioning is associated with slower destruction of the adenine nucleotide pool and a slower rate of anaerobic glycolysis during subsequent ischemic stress. Whether this association is causal is uncertain. Using metabolite levels found at baseline and after a 15 min test episode of ischemia, this study te...
3,713
Left atrial appendage dysfunction in chronic nonvalvular atrial fibrillation is significantly associated with an elevated level of brain natriuretic peptide and a prothrombotic state.
The study tested the hypothesis that left atrial appendage (LAA) dysfunction in nonvalvular atrial fibrillation (NVAF) correlates with a prothrombotic state, and investigated whether the plasma natriuretic peptides are marker of LAA dysfunction in NVAF. Sixty-seven patients underwent transthoracic and transesophageal e...
3,714
Heart emergency room: effective for both geriatric and younger patients.
To compare the 30-day cardiac event rate between patients aged at least 60 years (geriatric group) with those younger than 60 (younger group), who were enrolled in an Emergency department-based chest pain centre management protocol.</AbstractText>This was a retrospective, cohort study done at the Centre for Emergency C...
3,715
Pseudoventricular fibrillation.
A case of atrial fibrillation with asystole was diagnosed as ventricular fibrillation because of the autogain feature of the electrocardiographic monitor. Direct current shock therapy was withheld only because the patient regained consciousness.
3,716
Dual-site atrial pacing for atrial fibrillation in patients without bradycardia.
Atrial pacing has been shown to delay the onset of atrial fibrillation (AF) when compared with ventricular pacing in patients with sick sinus syndrome. The role for pacing in the control of AF in patients without bradycardia is uncertain. We performed a randomized, crossover, single-blinded study in 22 patients (14 wom...
3,717
Magnetic resonance real-time imaging for the evaluation of left ventricular function.
New ultrafast gradient systems and hybrid imaging sequences make it possible to acquire a complete image in real time, without the need for breathholding or electrocardiogram (ECG) triggering. In 21 patients, left ventricular function was assessed by the use of a turbo-gradient echo technique, an echo-planar imaging (E...
3,718
[Ligands of opioid and sigma receptors and correction of cardiac electrical instability in post-infarction cardiosclerosis].
Peripheral administration of the mu- or kappa-receptor agonists or sigma-receptor antagonists produced a significant receptor-dependent increase in the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. The effect was not observed upon administration of the epsilon-receptor agonist beta-end...
3,719
Epidemiologic evidence of cardiovascular effects of particulate air pollution.
In the past decade researchers have developed a body of epidemiologic evidence showing increased daily cardiovascular mortality and morbidity associated with acute exposures to particulate air pollution. Associations have been found not only with cardiovascular deaths reported on death certificates but also with myocar...
3,720
Serious cardiac complications during bone marrow transplantation at the University of Minnesota, 1977-1997.
Cardiac complications may result from high-dose chemotherapy or irradiation administered during the conditioning phase of bone marrow and blood stem cell transplantation (BMT). To assess the frequency of clinically serious cardiac toxicity related to the acute phase of BMT, we retrospectively examined life-threatening ...
3,721
Bench to bedside: resuscitation from prolonged ventricular fibrillation.
Ventricular fibrillation (VF) remains the most common cardiac arrest heart rhythm. Defibrillation is the primary treatment and is very effective if delivered early within a few minutes of onset of VF. However, successful treatment of VF becomes increasingly more difficult when the duration of VF exceeds 4 minutes. Clas...
3,722
[Transesophageal electrophysiologic study: utility in the diagnosis of syncope].
Neurocardiogenic and arrhythmic syncope are very common and may be found in many patients in Emergency Departments or admitted to hospitals. Technologic advances now allow etiologic diagnosis to be determined but the importance of a detailed clinical history and physical examination can not be overemphasized in the eva...
3,723
A short-time multifractal approach for arrhythmia detection based on fuzzy neural network.
We have proposed the notion of short-time multifractality and used it to develop a novel approach for arrhythmia detection. Cardiac rhythms are characterized by short-time generalized dimensions (STGDs), and different kinds of arrhythmias are discriminated using a neural network. To advance the accuracy of classificati...
3,724
Variation in the dominant period during ventricular fibrillation.
Time-varying periodicities are commonly observed in biological time series. In this paper, we discuss three different algorithms to detect and quantify change in periodicity. Each technique uses a sliding window to estimate periodic components in short subseries of a longer recording. The three techniques we utilize ar...
3,725
Acute renal failure after successful cardiopulmonary resuscitation.
To assess the frequency and independent predictors of severe acute renal failure in patients resuscitated from out-of-hospital ventricular fibrillation cardiac arrest.</AbstractText>A cohort study with a minimum follow-up of 6 months.</AbstractText>Emergency department of a tertiary care 2200-bed university hospital.</...
3,726
[Right ventricular heart failure in hyperthyroidism].
Cardiovascular disorders in patients affected with hyperthyroidism are very common; the increase in the heart rate and in inotropism combines with a rise in the cardiac index towards which the reduction in peripheral resistances and an increase in the venous return to the heart contribute. The increase in myocardial ex...
3,727
Predictors of atrial flutter with 1:1 conduction in patients treated with class I antiarrhythmic drugs for atrial tachyarrhythmias.
The purpose of the study was to look for the predictor factors of atrial proarrhythmic effects of class I antiarrhythmic drugs.</AbstractText>Class I antiarrhythmic drugs may induce or exacerbate cardiac arrhythmias. The predictors of ventricular proarrhythmia are known. The predictors of atrial flutter with 1:1 conduc...
3,728
Pathological analysis of myocardial cell under ventricular tachycardia and fibrillation based on symbolic dynamics.
Ventricular fibrillation (VF) is one of the most serious malignant arrhythmias usually resulting from immediate degeneration of ventricular tachycardia (VT). In order to analyse the nonlinear dynamics of the cardiac micro-mechanism under VT and VT rhythm, at the cellular level, myocardial cell action potentials are inv...
3,729
Initial experience with single lead intracardial cardioversion for refractory atrial fibrillation.
Chronic atrial fibrillation (AF) is a common arrhythmia, associated with a substantial morbidity (thromboemboli, worsening left ventricular function). Established therapy for pharmacological refractory AF is high-energy trans-thoracic electric cardioversion (TTCV), but this strategy is ineffective for 10-30% of the pat...
3,730
What is cardiac resynchronization therapy?
Cardiac resynchronization refers to pacing techniques that change the degree of atrial and ventricular electromechanical asynchrony in patients with major atrial and ventricular conduction disorders. Atrial and ventricular resynchronization is usually accomplished by pacing from more than one site in an electrical cham...
3,731
Report of a life-threatening arrhythmia after hospital discharge in a liver transplant recipient with previously unknown congenital long QT syndrome.
The long QT syndrome affects heart rhythm by prolonging ventricular repolarisation; it is potentially life-threatening since it can evolve into torsades de pointes (a polymorphic ventricular tachycardia) and/or ventricular fibrillation. The case is presented of a 55-year-old liver transplant recipient with a geneticall...
3,732
Potassium status of Northeast Thai constructors in three different geographic locations.
Sudden and unexpected death of young adults during sleep is a phenomenon among Southeast Asians and particularly young Northeast (NE) Thailand constructors in Singapore. Survivor of sudden unexplained death syndrome (SUDS) without structural heart disease with idopathic ventricular fibrillation (VF) has been documented...
3,733
From genes to whole organs: connecting biochemistry to physiology.
The successful analysis of physiological processes requires quantitative understanding of the functional interactions between the key components of cells, organs and systems, and how these interactions change in disease states. This information does not reside in the genome, or even in the individual proteins that gene...
3,734
Prevalence of left atrial chamber and appendage thrombi in patients with atrial flutter and its clinical significance.
The study was done to assess the prevalence of left atrial (LA) chamber and appendage thrombi in patients with atrial flutter (AFl) scheduled for electrophysiologic study (EPS), to evaluate the prevalence of thromboembolic complications after transesophageal echocardiographic (TEE)-guided restoration of sinus rhythm an...
3,735
Prevalence and mortality of the Brugada-type electrocardiogram in one city in Japan.
We sought to study the prevalence and mortality of subjects exhibiting the Brugada-type electrocardiogram (ECG) in a community-based population in Japan.</AbstractText>The Brugada syndrome has been associated with sudden death in subjects without structural heart disease. Hospital-based studies showed 11% to 38% annual...
3,736
The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram: a population-based study of four decades.
We sought to demonstrate the prevalence, incidence and prognostic value of the Brugada-type electrocardiogram (ECG) in a general population.</AbstractText>The Brugada syndrome is characterized by evidence of right bundle branch block and ST segment elevation in the right precordial leads, as well as sudden death caused...
3,737
Acute toxicities of betel nut: rare but probably overlooked events.
Betel nut chewing has long been a social habit in Taiwan and other Asian and tropical countries. It produces various autonomic and psychoneurologic effects including tachycardia, flushing, warmth, cholinergic activation, alertness, and euphoria. Although the oral carcinogenic effects are well known, data concerning its...
3,738
Antiarrhythmic drug use in the implantable defibrillator arm of the Antiarrhythmics Versus Implantable Defibrillators (AVID) Study.
Previous retrospective or observational series suggest that many patients with an implantable cardioverter-defibrillator (ICD) will be treated with antiarrhythmic drugs (AADs) to modify the frequency or manifestation of recurrent ventricular arrhythmias. The relative clinical benefit, however, is uncertain, and deleter...
3,739
Effect of carvedilol on survival and hemodynamics in patients with atrial fibrillation and left ventricular dysfunction: retrospective analysis of the US Carvedilol Heart Failure Trials Program.
Atrial fibrillation (AF) is present in a significant number of patients with congestive heart failure (CHF) caused by left ventricular dysfunction and is associated with significant morbidity and increased mortality rates. Thus it is necessary to establish therapy to improve the outcome in this high-risk population.</A...
3,740
Treatment of congestive heart failure--current status of use of digitoxin.
Digitalis glycosides exert a positive inotropic effect, i.e. an increase in myocardial contractility associated with a prolongation of relaxation period, and glycosides lower the heart rate (negative chronotropic), impede stimulus conduction (negative dromotropic) and promote myocardial excitability (positive bathmotro...
3,741
[Complications of stress echocardiography].
Stress echocardiography is an established clinical testing method and is accurate for the detection of coronary artery disease. Despite its widespread use, the safety of stress echocardiography has not been sufficiently documented in Japanese laboratories.</AbstractText>The feasibility, safety, complications and side e...
3,742
Performance and error analysis of automated external defibrillator use in the out-of-hospital setting.
We determined whether automated external defibrillators (AEDs) can meet the American Heart Association performance criteria to detect and shock unstable cardiac rhythms (ventricular fibrillation [VF], ventricular tachycardia [VT]) in the setting of an out-of-hospital cardiac arrest.</AbstractText>AED performance was re...
3,743
Out-of-hospital defibrillation with automated external defibrillators: postshock analysis should be delayed.
The American Heart Association protocols for use of automated external defibrillators (AEDs) recommend that a rhythm analysis be done immediately after each defibrillation attempt. However, shock is often followed by electrical silence or marginally organized electrical activity before ventricular fibrillation (VF) or ...
3,744
Electrophysiologic basis by which epinephrine facilitates defibrillation after prolonged episodes of ventricular fibrillation.
Even though epinephrine has been shown to decrease the electrical stability of the heart, it is used extensively in cardiac resuscitation. The objective of this study is to document electrophysiologic parameters of epinephrine, which would facilitate defibrillation.</AbstractText>In 20 swine, electrically induced ventr...
3,745
Atrial therapies reduce atrial arrhythmia burden in defibrillator patients.
Approximately 25% of patients who receive an implantable cardioverter-defibrillator (ICD) to treat ventricular tachyarrhythmias have documented atrial tachyarrhythmias before implantation. This study assessed the ability of device-based prevention and termination therapies to reduce the burden of spontaneous atrial tac...
3,746
The efficacy of epinephrine or vasopressin for resuscitation during epidural anesthesia.
Cardiopulmonary resuscitation (CPR) during epidural anesthesia is considered difficult because of diminished coronary perfusion pressure. The efficacy of epinephrine and vasopressin in this setting is unknown. Therefore, we designed this study to assess the effects of epinephrine versus vasopressin on coronary perfusio...
3,747
Improving standard cardiopulmonary resuscitation with an inspiratory impedance threshold valve in a porcine model of cardiac arrest.
To improve the efficiency of standard cardiopulmonary resuscitation (CPR), we evaluated the potential value of impeding respiratory gas exchange selectively during the decompression phase of standard CPR in a porcine model of ventricular fibrillation. After 6 min of untreated cardiac arrest, anesthetized farm pigs weig...
3,748
Successful prevention of recurrent ventricular fibrillation by intravenous isoproterenol in a patient with Brugada syndrome.
Intravenous administration of isoproterenol restored the ST-segment configuration to nearly normal in the right precordial leads and completely prevented spontaneous VF attacks in a patient with Brugada syndrome. The formation of a Brugada-type ECG has been attributed to the transmural dispersion of repolarization of t...
3,749
Washing machine associated 50 Hz detected as ventricular fibrillation by an implanted cardioverter defibrillator.
This case report describes a patient with an automatic ICD who suffered a defibrillation shock without warning symptoms. An electrical interference can be observed in the stored EGM of the episode. The patient explained that the moment he felt the shock he was touching a washing machine. After correct grounding of this...
3,750
Increased levels of tissue plasminogen activator antigen and factor VIII activity in nonvalvular atrial fibrillation: relation to predictors of thromboembolism.
Given that nonvalvular atrial fibrillation (AF)-associated stroke can be either cardioembolic or atherothrombotic, we investigated the relationships between nonvalvular AF and hemostatic factors reflecting intrinsic thrombogenic and atherogenic potentials (tissue plasminogen activator [t-PA] antigen, plasminogen activa...
3,751
[Processes of left atrial remodeling in myocardial infarction survivors as shown by esophageal rheography].
To study the condition of the left atrium (LA) in patients with myocardial infarction (MI), 112 MI patients were compared to 24 healthy controls by the data obtained at ultrasonic investigation of the heart and esophageal rheography. 73.2% of the patients early after MI showed dilated LA. There were also changes in the...
3,752
Dispersion of cell-to-cell uncoupling precedes low K+-induced ventricular fibrillation.
We hypothesize that hypokalemia-related electrolyte imbalance linked with abnormal elevation of intracellular free Ca2+ concentration can cause metabolic disturbances and subcellular alterations resulting in intercellular uncoupling, which favor the occurrence of malignant arrhythmias. Langendorff-perfused guinea pig h...
3,753
Arrhythmogenic right ventricular cardiomyopathy: current diagnostic and management strategies.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease of unknown etiology characterized by the peculiar right ventricular (RV) involvement. Distinctive pathologic features are myocardial atrophy and fibro-fatty replacement of the RV free wall, and clinical presentation is usually related to v...
3,754
Management of atrial flutter.
Atrial flutter is a macroreentrant arrhythmia that is associated with cardiovascular and pulmonary disease. In the United States, 200,000 new cases of atrial flutter can be expected to develop every year with a male to female ratio of over 2:1. This arrhythmia is associated with atrial fibrillation in over half the cas...
3,755
[Effectiveness and safety of catheter ablation of the heart conduction tracts in tachyarrhythmia].
An analysis of 490 operations of radiofrequency catheter destruction in 442 patients aged from 5 to 83 years has been made. 284 patients (64.3%) had congenital and "idiopathic" character of rhythm disturbances. The greater part of operations--459 (93.7%)--were performed on patients with supraventricular tachycardias, 3...
3,756
What is the optimal evaluation time of the QT dispersion after acute myocardial infarction for the risk stratification?
The sequential changes of the corrected QT dispersion (QTcD) were studied in 136 patients 1 day to 30 days after a transmural acute myocardial infarction (AMI) to investigate the optimal measurement time of QT dispersion for risk stratification. The study group included 136 patients (89 men; mean age, 57+/-10 years) wi...
3,757
Prognostic factors of the results of cardiopulmonary resuscitation in a cardiology hospital.
To analyze the early and late results of cardiopulmonary resuscitation in a cardiology hospital and to try to detect prognostic determinants of both short- and long-term survival.</AbstractText>A series of 557 patients who suffered cardiorespiratory arrest (CRA) at the Dante Pazzanese Cardiology Institute over a period...
3,758
Efficacy of pacing therapies for treating atrial tachyarrhythmias in patients with ventricular arrhythmias receiving a dual-chamber implantable cardioverter defibrillator.
Although overdrive pacing for treating atrial flutter is well established, the efficacy of device-based atrial pacing for treating spontaneous atrial tachyarrhythmias in patients with implantable cardioverter defibrillators (ICD) is unknown. This study evaluated the efficacy of novel pacing therapies for treating atria...
3,759
Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences.
The Na+/Ca2+ exchanger plays a prominent role in regulating intracellular Ca2+ levels in cardiac myocytes and can serve as both a Ca2+ influx and efflux pathway. A novel inhibitor, KB-R7943, has been reported to selectively inhibit the reverse mode (i.e., Ca2+ entry) of Na+/Ca2+ exchange transport, although many aspect...
3,760
The incidence of out-of-hospital ventricular fibrillation in Helsinki, Finland, from 1994 to 1999.
Early defibrillation by emergency medical services has been a success story in the treatment of ventricular fibrillation. This success has been followed by recommendations to allow public access to defibrillation equipment. We tracked the changes in incidence of ventricular fibrillation from prospectively collected dat...
3,761
Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study.
Accurate data for prevalence rates for heart failure due to various causes, and for left-ventricular systolic dysfunction in all adults are unavailable. Our aim was to assess prevalence of left-ventricular systolic dysfunction and heart failure in a large representative adult population in England.</AbstractText>Of 628...
3,762
Atrial defibrillation thresholds of electrode configurations available to an atrioventricular defibrillator.
Little investigation has been conducted to assess the atrial defibrillation thresholds of electrode configurations using electrodes designed for internal ventricular defibrillation (right ventricle [RV], superior vena cava [SVC], and pulse generator housing [Can]) combined with coronary sinus (CS) electrodes. We hypoth...
3,763
Evaluation of left ventricular function and mitral regurgitation during left ventricular-based pacing in patients with heart failure.
Beneficial effects of left ventricular (LV)-based pacing on acute hemodynamic parameters were reported in several series, but only a few studies examined the long-term effects of this new pacing procedure.</AbstractText>To assess long-term effects of permanent LV-based pacing on LV function and mitral regurgitation (MR...
3,764
Beneficial effect of carvedilol on heart rate response to exercise in digitalised patients with heart failure in atrial fibrillation due to idiopathic dilated cardiomyopathy.
Fourteen digitalised patients diagnosed with heart failure (NYHA Functional class II) with idiopathic dilated cardiomyopathy in chronic established atrial fibrillation were administered carvedilol in addition to their anti-heart failure medications in an attempt to improve their heart rate control. Fourteen matched pat...
3,765
[Cardiogenic ischemic strokes: pathogenetic aspects].
Eighty-three patients with acute ischemic stroke (56 men and 27 women, mean age 90.1 +/- 10.8 years) were examined in order to elucidate the significance of paroxysmal heart rhythm disorders and silent myocardial ischemia and determine the pattern of hemorheological changes. Traditional clinical instrumental examinatio...
3,766
[Identification of patients with acute myocardial infarction that may be discharged early: prospective evaluation with simple clinical and instrumental indicators].
The hospital stay for "uncomplicated" acute myocardial infarction (AMI) is often too long. A reduction in the length of hospitalization, if proven to be safe, is advantageous in terms of costs and health organization. Accordingly the aims of the present, prospective study, were to evaluate: 1) the patients with AMI eli...
3,767
[Complications in administration of contrast media in the catheterization laboratory: a 5-year retrospective study].
Iodine contrast substances (CS) are used since the twenties of the 20th century. From the chemical aspect benzoic acid derivatives are involved which are classified according to their osmolality (high-low- and isoosmolar) tendency of ionization (ionic and non-ionic) and according to the molecular structure monomers and...
3,768
Comparison of epinephrine with vasopressin on bone marrow blood flow in an animal model of hypovolemic shock and subsequent cardiac arrest.
The intraosseous route is an emergency alternative for the administration of drugs and fluids if vascular access cannot be established. However, in hemorrhagic shock or after vasopressors are given during resuscitation, bone marrow blood flow may be decreased, thus impairing absorption of intraosseously administered dr...
3,769
Severe cardiac arrhythmia on fexofenadine?
(1) One case of ventricular fibrillation during fexofenadine administration has been reported in a man with a pre-existing long QT interval.
3,770
Shock reduction using antitachycardia pacing for spontaneous rapid ventricular tachycardia in patients with coronary artery disease.
Implantable cardioverter-defibrillators (ICDs) can terminate some ventricular tachycardias (VTs) painlessly with antitachycardia pacing (ATP). ATP has not routinely been applied for VT &gt;188 bpm because of concerns about efficacy, risk of acceleration, and delay of definitive shock therapy. This prospective, multicen...
3,771
Phased chest and abdominal compression-decompression versus conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest.
Several methods have been developed to improve the efficacy of mechanical resuscitation, because organ perfusion achieved with conventional manual resuscitation is often insufficient. In animal studies, phased chest and abdominal compression-decompression resuscitation by use of the Lifestick device has resulted in a b...
3,772
Isolated non-compaction of the left ventricle: a rare indication for transplantation.
This report describes the diagnostic difficulty encountered in a young female patient presenting with neurologic symptoms, atrial fibrillation and severe left ventricular systolic dysfunction, eventually leading to cardiac transplantation. The scrutiny used in the evaluation of the particular aspect of the left ventric...
3,773
Characterization of post-discharge atrial fibrillation following open-heart surgery in uncomplicated patients referred to an early rehabilitation program.
Atrial fibrillation (AF) is frequently observed after open-heart surgery, following discharge from the cardiac surgery clinic. Compared to those usually reported in the early postoperative period, this arrhythmia is delayed in onset and is often a cause of re-hospitalization. Post-discharge AF has never been characteri...
3,774
Plasma CPU-86017 concentrations regarding suppression of ouabain-induced cardiac arrhythmias and decrease of heart rate in guinea pigs.
To determine the effective plasma levels of CPU-86017 which could suppress the cardiac arrhythmias induced by i.v. ouabain in guinea pigs.</AbstractText>The cardiac arrhythmias and the heart rate were monitored by ECG traces. Blood samples were collected to determine plasma levels using HPLC assay. TXB2 and 6-keto-PGF1...
3,775
Characterization of the 16 blanking periods of the Medtronic GEM DR dual chamber defibrillators.
We determined the blanking periods of the Medtronic GEM DR dual chamber defibrillators by using a simulator to deliver signals mimicking arrhythmias into external devices programmed to various settings. The blanking periods for the tachycardia and bradycardia functions were measured in the atrial and ventricular channe...
3,776
Merits and limitations of the mode switching rate stabilization pacing algorithms in the implantable cardioverter defibrillator.
The 7250 Jewel AF Medtronic model of ICD is the first implantable device in which both therapies for atrial arrhythmias and pacing algorithms for atrial arrhythmia prevention are available. Feasibility of that extensive atrial arrhythmia management requires correct and synergic functioning of different algorithms to co...
3,777
Interactions between pacing and arrhythmia detection algorithms in the dual chamber implantable cardioverter defibrillator.
Dual chamber implantable cardioverter defibrillator (ICD) combines the possibility to detect and treat ventricular and atrial arrhythmias with the possibility of modern heart stimulation techniques. Advanced pacing algorithms together with extended arrhythmia detection capabilities can give rise to new types of device-...
3,778
Atrial fibrillation: a risk factor for increased mortality--an AVID registry analysis.
Emerging evidence suggests that atrial fibrillation is not a benign arrhythmia. It is associated with increased risk of death. The magnitude of association is controversial and potential causes remain unknown. Patients in the registry of the Antiarrhythmics Versus Implantable Defibrillators (AVID) Trial form the basis ...
3,779
Significance of inducible ventricular fibrillation in patients with coronary artery disease and unexplained syncope.
This study was designed to determine the incidence and prognostic significance of inducible ventricular fibrillation (VF) in patients with coronary artery disease (CAD) and unexplained syncope.</AbstractText>Current American College of Cardiology/American Heart Association practice guidelines recommend implantation of ...
3,780
Results of surgical repair of ostium primum atrial septal defect in adult patients.
Ostium primum atrial septal defect (ASD I) is very rarely observed in the adults. Although ASD I was first corrected surgically almost 50 years ago, the efficacy of surgical treatment in adults has not been well documented. Thus, the long-term outcome of patients aged over 20 years and having surgical repair of ASD I w...
3,781
Atrial activity enhancement by Wiener filtering using an artificial neural network.
This paper describes a novel technique for the cancellation of the ventricular activity for applications such as P-wave or atrial fibrillation detection. The procedure was thoroughly tested and compared with a previously published method, using quantitative measures of performance. The novel approach estimates, by mean...
3,782
A malignant phenotype of hypertrophic cardiomyopathy caused by Arg719Gln cardiac beta-myosin heavy-chain mutation in a Chinese family.
Mutations of the cardiac beta-myosin heavy-chain (beta-MHC) gene cause hypertrophic cardiomyopathy (HCM). Recent genotype-phenotype correlation studies have shown that mutations carry prognostic significance. We studied five unrelated Chinese families with hypertrophic cardiomyopathy. Exons 3-27 and 40 of the beta-MHC ...
3,783
[Effect of percutaneous transvenous mitral commissurotomy for the preservation of sinus rhythm in patients with mitral stenosis].
Atrial fibrillation is frequently associated with mitral stenosis and is considered to be an unfavorable factor for the long-term prognosis. The efficacy of percutaneous transvenous mitral commissurotomy(PTMC) was examined for the preservation of sinus rhythm in patients with mitral stenosis after PTMC.</AbstractText>L...
3,784
Echocardiographic evaluation of right ventricular systolic functions in pure mitral stenosis.
Detailed echocardiographic evaluation of right ventricular muscle thickness and systolic functions was performed in twenty two cases of isolated rheumatic mitral stenosis without clinical signs of systemic venous congestion, tricuspid regurgitation or atrial fibrillation. Twenty two age and sex matched normal persons f...
3,785
[Implantable cardioverter-defibrillators in the prevention of sudden cardiac death].
The aim of this work is to characterize and analyse the spectrum of therapies delivered from implantable cardioverter-defibrillators (ICD), to evaluate their effectivity and to mark the most effective types of antitachycardia stimulations (ATP), cardioversion (CV) and defibrillation (CD). To compare our results with re...
3,786
[Heart failure in hypertensive patients with left ventricular hypertrophy].
Left ventricular hypertrophy (LVH) is supposed to be a useful marker of cardiovascular complications during the course of hypertension. Authors compared the presence of heart failure, left ventricular diastolic dysfunction and chronic atrial fibrillation in hypertensive patients with and without left ventricular hypert...
3,787
Ventricular fibrillation during off-pump coronary artery bypass grafting: transcranial Doppler and clinical findings.
A 73-year-old male developed ventricular fibrillation which lasted for 2 min and 24 s, during off-pump coronary artery bypass grafting. Cerebral hemodynamics were assessed by continuous transcranial Doppler monitoring. Ventricular fibrillation resulted in an immediate fall in cerebral blood flow velocities to almost ze...
3,788
Electrical induction of ventricular fibrillation for resuscitation from postcountershock pulseless and asystolic cardiac arrests.
There is increasing evidence that defibrillation from prolonged ventricular fibrillation (VF) before CPR decreases survival. It remains unclear, however, whether harmful effects are due primarily to initial countershock of ischemic myocardium or to resultant postdefibrillation rhythms (ie, pulseless electrical activity...
3,789
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.
Phosphodiesterase III inhibitors (PDEIII-Is) improve the hemodynamic status of heart failure via inotropic/vasodilatory effects attributable to the increase in intracellular cAMP level. Direct cardioprotection by PDEIII-Is and its underlying mechanisms, however, have not been identified. We tested the infarct size-limi...
3,790
[Circular hemorrhagic subendocardial necrosis after heart arrest and resuscitation].
A 19 year old boy, previously healthy suffered a cardiac arrest by getting up. Ten minutes afterwards the general practitioner commenced cardiopulmonary resuscitation, 15 minutes later ventricular fibrillation developed and the emergency physician carried out intubation and repeated defibrillation. During the next few ...
3,791
K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias.
Cardioprotection by K(ATP) channel openers during ischemia is well documented although ill understood. Proarrhythmic effects may be an important drawback. K(ATP) channel modulation influences neurotransmitter release during ischemia in brain synaptosomes. Therefore, we studied the effects of K(ATP) channel modulation o...
3,792
Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke.
Hypothermia is effective in improving outcome in experimental models of brain infarction. We studied the feasibility and safety of hypothermia in patients with acute ischemic stroke treated with thrombolysis.</AbstractText>An open study design was used. All patients presented with major ischemic stroke (National Instit...
3,793
Sotalol: the mechanism of its antiarrhythmic-defibrillating effect.
This minireview deals with the role of intercellular communication and synchronization in the initiation and maintenance of ventricular fibrillation. It is proposed that myocardial cell junctions might represent a therapeutic substrate for the prevention of this fatal arrhythmia. This hypothesis is supported by the res...
3,794
Multilateral in vivo and in vitro protective effects of the novel heat shock protein coinducer, bimoclomol: results of preclinical studies.
Bimoclomol, the recently developed non-toxic heat shock protein (HSP) coinducer, was shown to display multilateral protective activities against various forms of stress or injuries at the level of the cell, tissue or organism. The compound enhanced the transcription, translation and expression of the 70 kD heat shock p...
3,795
Effects of biphasic vs monophasic defibrillation on the scaling exponent in a swine model of prolonged ventricular fibrillation.
Mathematical analyses of ventricular fibrillation (VF) have resulted in the derivation of a measure termed the scaling exponent (ScE) that characterizes the duration of VF and probability of defibrillation success. The purpose of this study was to compare the effects of biphasic defibrillation waveform (BDW) and monoph...
3,796
Management of cardiac arrhythmias in acute coronary syndromes.
A variety of atrial and ventricular arrhythmias are encountered in patients with acute coronary syndromes. These include both brady and tachyarrhythmias of supraventricular and ventricular origin. Sinus bradycardia and atrial fibrillation are the most common of supraventricular origin. Ventricular arrhythmias that meri...
3,797
Clinical assessment of clonidine in the treatment of new-onset rapid atrial fibrillation: a prospective, randomized clinical trial.
The role of digoxin and verapamil in the control of ventricular response in rapid atrial fibrillation is well established. This study investigates how clonidine compares with these standard therapies in rate control for new-onset rapid atrial fibrillation. We set out to test the hypothesis that clonidine effectively re...
3,798
Safety and feasibility of a novel rate-smoothed ventricular pacing algorithm for atrial fibrillation.
This study was conducted to establish the safety and performance of a new rate-smoothing pacing algorithm for patients with atrial fibrillation (AF).</AbstractText>Irregularity of the ventricular response is a hallmark of AF. This irregularity may contribute to symptoms and hemodynamic compromise in patients with AF. I...
3,799
Management of the critically ill cardiac patient.
The decline in rheumatic fever has made heart disease in pregnancy an uncommon problem in the developed world but it remains an important cause of maternal morbidity and mortality in developing countries. Pregnancy is particularly dangerous in the presence of cyanotic congenital heart disease, Eisenmenger's syndrome, p...