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4,500 | Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. | The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wines, in the rat after ischemia and ischemia-reperfusion (I-R).</AbstractText>The left main coronary artery was occluded for 30 or 5 min followed by a 30-min reperfusion in anesthetized ra... |
4,501 | Reduction in defibrillation threshold using an auxiliary shock delivered in the middle cardiac vein. | Defibrillation in the middle cardiac vein (MCV) has been shown to reduce ventricular defibrillation thresholds (DFTs). Low amplitude auxiliary shock (AS) from an electrode sutured to the left ventricle at thoracotomy have also been shown to reduce DFT if delivered immediately prior to a biphasic shock (between the vent... |
4,502 | A prospective randomized-controlled trial of ventricular fibrillation detection time in a DDDR ventricular defibrillator. Ventak AV II DR Study Investigators. | Implantable cardioverter defibrillators (ICDs) with dual chamber and dual chamber rate responsive pacing may offer hemodynamic advantages for some ICD patients. Separate ICDs and DDDR pacemakers can result in device to device interactions, inappropriate shocks, and underdetection of ventricular fibrillation (VF). The o... |
4,503 | Electrophysiological control of ventricular rate during atrial fibrillation. | Thirteen anesthetized canine subjects (17-29 kg) were used to demonstrate that mild cervical left vagal stimulation could control ventricular rate effectively during atrial fibrillation (AF). Two studies are presented. The first study used six subjects to demonstrate the inverse relationship between (manually applied) ... |
4,504 | No gender differences in pacemaker selection in patients undergoing their first implantation. | Recent studies have indicated that women were less likely to receive sophisticated pacemaker devices than men. These differences could not be fully explained by demographic and clinical variables. The purpose of the present study was to assess whether a gender related difference might exist in pacemaker mode selection ... |
4,505 | [Intima-media complex thickness of common carotid artery as a risk factor for stroke]. | Intima-Media Thickness (IMT) of Common Carotid Artery (CCA) could be seen as the atherosclerotic risk factors' final morphological effect. We investigated the hypothesis that IMT of CCA is significantly different in sex- and age-matched groups of persons with stroke and healthy subjects. 47 patients with first-ever ath... |
4,506 | Experimental study of intermittent crossclamping with fibrillation and myocardial protection: reduced injury from shorter cumulative ischemia or intrinsic protective effect? | During coronary artery revascularization, some surgeons favor intermittent crossclamping with ventricular fibrillation in preference to cardioplegic ischemic arrest for myocardial protection. It is unclear, however, whether intermittent crossclamping with fibrillation is equally protective or whether ischemic injury is... |
4,507 | Effects of extracts from flowering tops of Crataegus meyeri A. Pojark. on ischaemic arrhythmias in anaesthetized rats. | Different species of Crataegus, commonly called Hawthorn, were reported to possess wide pharmacological effects on the cardiovascular system. In the present study, chloroform, ethylacetate and methanol (70%) extracts of the flowering tops of Crataegus meyeri A. Pojark. were studied. The extracts were tested on the inci... |
4,508 | Tolerability of large-dose intravenous levobupivacaine in sheep. | In preclinical pharmacological studies of levobupivacaine (S-bupivacaine), we determined its tolerability, cardiovascular actions, and pharmacokinetics, and we estimated its margin of safety compared with bupivacaine in conscious sheep. Levobupivacaine HCl. H(2)O was infused IV for 3 min into 10 previously instrumented... |
4,509 | Vasopressin improves survival after cardiac arrest in hypovolemic shock. | Survival after hypovolemic shock and cardiac arrest is dismal with current therapies. We evaluated the potential benefits of vasopressin versus large-dose epinephrine in hemorrhagic shock and cardiac arrest on vital organ perfusion, and the likelihood of resuscitation. In 18 pigs, 35% of the estimated blood volume was ... |
4,510 | T wave alternans can decrease after coronary revascularization. | Clinical observations and animal experiments indicate that T wave alternans (TWA) is associated with an increased propensity for ventricular fibrillation, and thus it may be considered as a noninvasive marker of life-threatening ventricular arrhythmias. There is substantial evidence indicating that TWA is an intrinsic ... |
4,511 | Safety and efficacy of high-dose adenosine-induced asystole during endovascular AAA repair. | To assess the safety and efficacy of high-dose adenosine administration to increase the precision of endovascular abdominal aortic aneurysm (AAA) repair using a balloon deployed stent-graft.</AbstractText>From January 1997 to March 1999, 98 AAA patients (79 men; mean age 71 years, range 62-91) were treated with balloon... |
4,512 | Apical hypertrophic cardiomyopathy due to a de novo mutation Arg719Trp of the beta-myosin heavy chain gene and cardiac arrest in childhood. A case report and family study. | Hypertrophic cardiomyopathy (HCM) is a myocardial disease with variable phenotpye and genotype. To demonstrate that the mutation Arg719Trp in the cardiac beta-myosin heavy chain (beta MHC) gene is a high risk factor for sudden death and can be associated with an unusual apical non-obstructive HCM, we report the case of... |
4,513 | [Complications of transesophageal echocardiography with dobutamine]. | The transesophageal echocardiographic approach improves the diagnostic power of transthoracic stress echocardiography. However, it is a seminvasive test and its safety is not well established. Our objective was to compare the incidence of complications of transesophageal and transthoracic dobutamine echocardiography. W... |
4,514 | Prognostic implications of ventricular fibrillation in acute myocardial infarction: new strategies required for further mortality reduction. | To determine the changing risk of ventricular fibrillation, the prognostic implications, and the potential long term prognostic benefit of earlier hospital admission, after acute myocardial infarction.</AbstractText>Prospective observational study.</AbstractText>A district general hospital in east London.</AbstractText... |
4,515 | Hemodynamic collapse, geometry, and the rapidly paced upper limit of ventricular vulnerability to fibrillation by T-wave stimulation. | There is an upper limit to the vulnerability (ULV) of the ventricles to fibrillation (VF) induced by T-wave stimuli. Across species, disease states, and pharmacological treatments, the ULV is correlated to the defibrillation threshold (DF50). However, one factor known to increase the ULV far above the DF50 is rapid pac... |
4,516 | Ventricular arrhythmias. Preventing sudden death with drugs and ICD devices. | Sudden cardiac death occurs most frequently in persons age 50 to 60, and serious ventricular arrhythmias are the cause of death in most cases. The underlying substrate is usually CAD, either a healed infarction or an acute ischemic event. Early studies using antiarrhythmic drugs to improve post-MI survival led instead ... |
4,517 | Emerging indications for permanent pacing. | New indications for pacing are being investigated in the areas of vasovagal syncope, hypertrophic obstructive cardiomyopathy, dilated cardiomyopathy, and atrial fibrillation. It is hoped that pacing will offer an alternative therapy to patients who are refractory to medical therapy. Although pacing for vasovagal syncop... |
4,518 | Implantable dual-chamber cardioverter-defibrillator-pacemaker. | The fifth generation of implantable cardioverter-defibrillators offer enhanced modes of detection of atrial and ventricular arrhythmias, antitachycardia pacing and shocks, multiprogrammability, intracardiac electrogram storage, and all functions of antibradycardia dual-chamber pacing including rate responsiveness and m... |
4,519 | Epidemiology of hypertrophic cardiomyopathy-related death: revisited in a large non-referral-based patient population. | Death resulting from hypertrophic cardiomyopathy (HCM), particularly when sudden, has been reported to be largely confined to young persons. These data emanated from tertiary HCM centers with highly selected referral patterns skewed toward high-risk patients.</AbstractText>The present analysis was undertaken in an inte... |
4,520 | Infarct size and recurrence of ventricular arrhythmias after defibrillator implantation. | Infarct size as determined by perfusion imaging is an independent predictor of mortality after implantable cardioverter defibrillator (ICD) implantation in patients with coronary artery disease (CAD) and life-threatening ventricular arrhythmias (VA). However, its value as a predictor of VA recurrence and hospitalisatio... |
4,521 | Swinging motion of intimal flap through the aortic valve in acute aortic dissection. | The purpose of this article is to present a very rare case of Stanford type A acute aortic dissection featuring a swinging motion of the cylinder-shaped intimal flap through the aortic valve. The patient was a 62-year-old male suffering from severe cardiogenic shock. A transthoracic echocardiogram revealed aortic disse... |
4,522 | 4-aminopyridine inhibits the occurrence of ventricular fibrillation but not ventricular tachycardia in the reperfused, P6olated rat heart. | The 4-aminopyridine (4-AP)-sensitive transient outward current (Ito) has been reported to play an important role in the ischemia- or high [Ca2+]o-induced reentrant ventricular arrhythmias. However, the role of 4-AP sensitive Ito in reperfusion arrhythmia remains unknown. Rat hearts were perfused with Tyrode solution (c... |
4,523 | The Brugada syndrome. Outcome of one case. | The Brugada syndrome is a rare condition, and due to its mutating manner of presentation it may be difficult to diagnose. We report one case and discuss the diagnostic aspects and the clinical outcome of one patient with characteristic findings of this syndrome. These findings are especially defined by J-ST elevation i... |
4,524 | Anticoagulant use in nonvalvular atrial fibrillation. Determining risk and choosing the safest course. | Previous TIA or stroke, diabetes, advanced age, impaired left ventricular function, and a history of hypertension are strong risk factors in patients with nonvalvular AF. When none of these factors is present, aspirin in a dose of 325 mg offers effective protection against future stroke. When any of these factors are p... |
4,525 | Radiofrequency catheter ablation for the treatment of supraventricular tachycardias in children and adolescents. | We report our experience in radiofrequency catheter ablation between April, 1992 and December, 1998, in which we treated 287 patients less than 18 years of age (mean 14.3 +/- 3.1 years) with supraventricular tachycardia. Accessory, pathways were the arrhythmic substrate in 252 of the patients (87.8%), the patients havi... |
4,526 | Outcomes of out-of-hospital ventricular fibrillation: their association with time to defibrillation and related issues in the defibrillation program in Japan. | The aim of this study was to provide data on the outcomes of out-of-hospital cardiac arrest caused by ventricular fibrillation (VFOHCA) and analyze factors influencing patient outcomes in order to further improve EMS system performance in the resuscitation of VFOHCA patients in Japan. A datasheet was mailed to the fire... |
4,527 | Lessons from reporting 100,000 Jamaican electrocardiograms. | The screening programme of the Heart Foundation of Jamaica has found hypertension in 71% of women and 47% of men. Of these patients, 13% were newly discovered hypertensives. Left ventricular hypertrophy was present in 18% of hypertensive women and in 27% of men. Inadequate control of raised blood pressure was a frequen... |
4,528 | Two-year mortality and its determinants following acute myocardial infarction in Trinidad and Tobago. | The purpose of this study was to determine the occurrence of coronary artery disease risk factors in patients presenting with acute myocardial infarction (AMI) to a tertiary care institution in Trinidad and to determine the factors associated with increased mortality following AMI. All patients admitted to the Eric Wil... |
4,529 | Management of patients with prosthetic heart valves: potential impact of valve site, clinical characteristics, and comorbidity. | Nearly four decades have passed since the first mechanical prosthetic aortic valve was placed. Since then several design changes and modifications have been made to improve longevity and hemodynamics and reduce thrombogenicity. Despite these advances thromboembolism remains the major problem for mechanical prosthetic v... |
4,530 | A comparison between patients suffering in-hospital and out-of-hospital cardiac arrest in terms of treatment and outcome. | To compare treatment and outcome amongst patients suffering in-hospital and out-of-hospital cardiac arrest in the same community.</AbstractText>All patients suffering in-hospital cardiac arrest in Sahlgrenska University Hospital covering half the catchment area of the community of Göteborg (500 000 inhabitants) an... |
4,531 | Transgenic rat hearts expressing a human cardiac troponin T deletion reveal diastolic dysfunction and ventricular arrhythmias. | Familial hypertrophic cardiomyopathy (FHC) due to mutations of cardiac troponin T (cTnT) is associated with a high frequency of sudden death even in the absence of cardiac hypertrophy. To investigate the causal relationship of cTnT mutations and this particular phenotype, we sought to establish a transgenic rat model f... |
4,532 | [Sudden cardiac death out of the hospital and early defibrillation]. | Since most sudden cardiac death victims show neither symptoms before the event nor other signs or risk factors that would have identified them as a high risk population before their cardiac arrest, emergency out-of-hospital medical services must be improved in order to obtain a higher survival in these patients. Early ... |
4,533 | Tachycardia-related cardiomyopathy: a common cause of ventricular dysfunction in patients with atrial fibrillation referred for atrioventricular ablation. | To determine the frequency of tachycardia-related cardiomyopathy in patients with atrial fibrillation and systolic dysfunction referred for atrioventricular node ablation.</AbstractText>This prospective multicenter cohort study was conducted at 16 tertiary care centers. The ejection fraction was measured before and 3 a... |
4,534 | Treating electrical storm : sympathetic blockade versus advanced cardiac life support-guided therapy. | Electrical storm (ES), defined as recurrent multiple ventricular fibrillation (VF) episodes, often occurs in patients with recent myocardial infarction. Because treating ES according to the Advanced Cardiac Life Support (ACLS) guidelines yields a poor outcome, we evaluated the efficacy of sympathetic blockade in treati... |
4,535 | A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. | Mutations in the human cardiac Na+ channel alpha subunit gene (SCN5A) are responsible for Brugada syndrome, an idiopathic ventricular fibrillation (IVF) subgroup characterized by right bundle branch block and ST elevation on an electrocardiogram (ECG). However, the molecular basis of IVF in subgroups lacking these ECG ... |
4,536 | Clinical relevance of silent atrial fibrillation: prevalence, prognosis, quality of life, and management. | Although first described about 100yr ago, atrial fibrillation (AF) is now recognized as the most common of all arrhythmias. It has a substantial morbidity and presents a considerable health care burden. Improved diagnosis and an ageing population with an increased likelihood of underlying cardiac disease results in AF ... |
4,537 | Cardiovascular effects of intravenous diltiazem in dogs with iatrogenic atrial fibrillation. | Atrial fibrillation (AF) was induced in anesthetized Beagle hounds to determine the dose of diltiazem (D) that resulted in hemodynamic function similar to that observed during sinus rhythm (SR). Dogs were instrumented to record hemodynamic and electrophysiological parameters. Six dogs were given D, IV at cumulative dos... |
4,538 | Effects of acute gastric distention and recovery on tendency for ventricular arrhythmia in dogs. | The gastric distention-volvulus (GDV) syndrome occurs commonly in large-breed dogs and may prove fatal in 15-68% of cases. Approximately 43% of cases with gastric distention (GD) or volvulus develop cardiac arrhythmias that can contribute to mortality. Most of these arrhythmias are ventricular in origin and ventricular... |
4,539 | Spectral turbulence and late potentials in the signal-averaged electrocardiograms of patients with monomorphic ventricular tachycardia versus resuscitated ventricular fibrillation. | Signal-averaged electrocardiograms (SAECG) were analyzed for late potentials and spectral turbulence in 208 patients with ischemic heart disease with a history of sustained monomorphic ventricular tachycardia (MVT) (n = 62), resuscitation from ventricular fibrillation (VF) (n = 64) or no ventricular tachyarrhythmia (n ... |
4,540 | [Dilated thyrotoxic cardiomyopathy]. | We report a case of reversible, dilated cardiomyopathy due to thyrotoxicosis, which occurred in a young male without any underlying heart disease. The patient presented a clinical picture of cardiogenic shock related to severe left ventricular dilation and dysfunction and with new-onset atrial fibrillation and very hig... |
4,541 | [Use of percutaneous cardiopulmonary support (PCPS) for extended surgery in patients with T4 tumor]. | Since 1991, we have performed operations for tumors invading the upper airway, left atrium or main pulmonary artery with percutaneous cardiopulmonary support (PCPS) stand by support available. Of 15 cases with PCPS stand by, 6 patients actually underwent operation using PCPS. There were three esophageal cancers invadin... |
4,542 | Attenuation of KATP channel-opener induced shortening of repolarization time by alpha 1-adrenoceptor antagonist during ischemia in canine heart. | The purpose of the study was to determine whether a new KATP channel opener, Y 26763 (Y), can influence the electrophysiological properties in the ischemic myocardium as well as to determine whether the blunting effect of the alpha 1-adrenoceptor antagonist bunazosin (BN) on an ischemia-induced shortening of repolariza... |
4,543 | Clusters of ventricular tachycardias signify impaired survival in patients with idiopathic dilated cardiomyopathy and implantable cardioverter defibrillators. | This retrospective study was undertaken to provide data on occurrence, significance and therapy of ventricular tachyarrhythmia (VT) clusters (VTCs) in patients with dilated cardiomyopathy (DCM) and implantable cardioverter defibrillators (ICDs).</AbstractText>Data on the clinical significance of VTCs are lacking in pat... |
4,544 | Ventricular tachycardias above the initially programmed tachycardia detection interval in patients with implantable cardioverter-defibrillators: incidence, prediction and significance. | This retrospective study was performed to provide data on ventricular tachycardias (VT) with a cycle length longer than the initially programmed tachycardia detection interval (TDI) in patients with implantable cardioverter defibrillators (ICDs).</AbstractText>It has been clinical practice to program a safety margin of... |
4,545 | Intravenous versus oral initial load of propafenone for conversion of recent-onset atrial fibrillation in the emergency room: a randomized trial. | Non-valvular paroxysmal atrial fibrillation is a common clinical condition associated with a high risk of thromboembolism and hemodynamic problems which increase with the duration of arrhythmia. Therefore, even if arrhythmia ceases spontaneously within 24 hours in about half of the patients, a higher early conversion r... |
4,546 | [Pharmacological cardioversion with intravenous propafenone in atrial fibrillation]. | The efficacy and safety of intravenous propafenone for conversion of recent-onset and chronic atrial fibrillation was assessed in 46 patients. 40 with atrial fibrillation associated with or without structural heart disease (mean age 63 +/- 14 years) and 6 patients with atrial fibrillation related to the Wolff-Parkinson... |
4,547 | Amiodarone-induced bone marrow granulomas. | Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias. In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (cas... |
4,548 | Early outcome of initiating amiodarone for atrial fibrillation in advanced heart failure. | Little information exists about the early outcomes of initiating amiodarone for atrial fibrillation in patients with advanced heart failure. This study assessed the initial rate of success and complications of amiodarone therapy initiated for patients with atrial fibrillation during hospitalization for heart failure.</... |
4,549 | Percutaneous cardiopulmonary support as a bridge to emergency operation--two surviving cases. | Two patients had percutaneous cardiopulmonary support (PCPS) used as a bridge to emergency surgery. A 66-year-old man admitted with profound cardiogenic shock underwent direct stenting under PCPS with the diagnosis of acute myocardial infarction of the left main trunk, with the intention of performing revascularization... |
4,550 | Automatic atrial tachyarrhythmia detection from intracardiac electrograms. | Automatic atrial tachyarrhythmia recognition is crucial in order to allow a correct switching-mode function of dual-chamber pacemakers and to avoid inappropriate shocks of ventricular implantable cardioverter-defibrillators. In this paper we considered three algorithms suitable for implantable devices. The first was ba... |
4,551 | [Administration of adenosine for termination of atrioventricular nodal reentry tachycardia: induction of atrial fibrillation with rapid conduction over an accessory pathway and unmasking of concomitant Wolff-Parkinson-White syndrome]. | The antiarrhythmic properties of adenosine, its ultra-short half-life and the absence of frequent serious side effects make it a front-line agent in arrhythmia management, especially in the treatment of atrioventricular nodal reentrant tachycardia. Due to a shortening of atrial refractoriness, adenosine can facilitate ... |
4,552 | Control of idiopathic ventricular fibrillation by implantable cardioverter-defibrillator in a child who survived sudden death. | Idiopathic ventricular fibrillation (VF) is extremely rare in children who have not previously undergone cardiac surgery. Patients resuscitated from idiopathic VF remain at risk for recurrence. The use of an implantable cardioverter-defibrillator (ICD) effectively prevents such recurrences. We report the case of a 12-y... |
4,553 | Carotid Doppler high-intensity transient signals in dilated cardiomyopathy. | Thromboembolism is an infrequent but serious complication in dilated cardiomyopathy (DCM), and the role of primary preventive antithrombotic or anticoagulation therapy is undetermined. High-intensity transient signals (HITS) by Doppler ultrasound representing microemboli have been described in various clinical settings... |
4,554 | Influence of coronary anatomy and reimplantation on the long-term outcome of the arterial switch. | Abnormal coronary artery anatomy is reported to have a significant influence on the outcome of the arterial switch operation. This study examines the impact of coronary anatomy and the occurrence of late coronary obstruction on left ventricular (LV) function and long-term outcome.</AbstractText>Coronary artery anatomy,... |
4,555 | Comparison of intravenously administered dofetilide versus amiodarone in the acute termination of atrial fibrillation and flutter. A multicentre, randomized, double-blind, placebo-controlled study. | This study compared the efficacy and safety of intravenous dofetilide with amiodarone and placebo in converting atrial fibrillation or flutter to sinus rhythm.</AbstractText>One hundred and fifty patients with atrial fibrillation or flutter (duration range 2 h-6 months) were given 15-min intravenous infusions of 8 micr... |
4,556 | Experiences from treatment of out-of-hospital cardiac arrest during 17 years in Göteborg. | To describe changes in different factors at resuscitation and survival in a 17-year survey of patients suffering from out-of-hospital cardiac arrest.</AbstractText>The investigation was carried out in the community of Göteborg with 450 000 inhabitants during 1981-1997 on all patients suffering out-of-hospital card... |
4,557 | Prognostic value of the presence and development of atrial fibrillation in patients with advanced chronic heart failure. | To examine whether the presence, or development, of atrial fibrillation in patients with advanced chronic heart failure, is associated with a poorer prognosis, compared to patients with sinus rhythm and chronic heart failure.</AbstractText>We examined 409 patients with moderate to severe chronic heart failure, and comp... |
4,558 | Termination of acute wide QRS complex atrial fibrillation with ibutilide. | Ibutilide is a Vaughan-Williams class III antiarrhythmic agent approved for chemical cardioversion of acute onset atrial fibrillation/flutter. Emergency physicians rarely use ibutilide despite its proven clinical value. We report a case of successful chemical cardioversion using ibutilide in a patient with atrial fibri... |
4,559 | Changes in chest electrode impedance. | The Prehospital Defibrillation Program in Singapore has in some cases shown a lower amplitude of ventricular fibrillation (VF) than considered the norm. The electrode skin impedance (ESI) refers to the skin impedance determined between two electrodes placed at specific positions on the body surface. The objective of th... |
4,560 | Ventricular arrhythmias. | Sudden cardiac death remains a leading cause of death in the United States. It is usually due to ventricular arrhythmia, either ventricular tachycardia or ventricular fibrillation. The probability of life threatening ventricular arrhythmia correlates closely with underlying structural heart disease. In any patient pres... |
4,561 | Management of arrythmias. | The management of arrhythmias in elderly patients with congestive heart failure, including atrial fibrillation, ventricular tachyarrhythmias, and bradyarrhythmias, is described. Patients with atrial fibrillation can be treated with rate control anticoagulation for stroke prevention or by attempt at cardioversion and ma... |
4,562 | Heart failure complicating acute myocardial infarction. | Older people with congestive heart failure associated with acute myocardial infarction should be treated with loop diuretic therapy. Class I indications for the use of early intravenous beta blockade in patients with acute myocardial infarction are patients without a contraindication to beta blockers who can be treated... |
4,563 | Frequency modulation within electrocardiograms during ventricular fibrillation. | Periods of reentrant activation and effective refractory periods are correlated with dominant frequency or reciprocal of cycle periods during ventricular fibrillation (VF). In the present study, we used an analysis technique based on Wigner transforms to quantify time-varying dominant frequencies in electrocardiograms ... |
4,564 | Mitral annular dynamics during rapid atrial pacing. | Ovine mitral annular area (MAA) reduction predominantly occurs before ventricular systole. We used the myocardial marker methods to investigate left atrial and MAA dynamics during rapid atrial pacing.</AbstractText>Seven sheep underwent implantation of 21 myocardial markers around the mitral annulus, the left ventricle... |
4,565 | Identification of patients at risk by graded exercise testing in an emergency department chest pain center. | The study applied a retrospective follow-up design to determine the prognostic effect of graded exercise testing (GXT) in patients with low- to moderate-risk chest pain evaluated in an emergency department 9-hour protocol chest pain center (CPC) from January 1, 1993 to August 1, 1996. The cohort of 1,209 patients were ... |
4,566 | Temporal organization of atrial activity and irregular ventricular rhythm during spontaneous atrial fibrillation: an in vivo study in the horse. | Atrial fibrillation (AF) is common in healthy horses. We studied the temporal organization of AF to test the hypothesis that the arrhythmia is governed by a high degree of periodicity and therefore is not random in the horse. Further, we surmised that concealed conduction of AF impulses in the AV node results in an inv... |
4,567 | Three-dimensional mapping of spontaneous ventricular arrhythmias in a canine thrombotic coronary occlusion model. | Ventricular tachycardia (VT) and ventricular fibrillation (VF) induced by thrombotic coronary occlusion were mapped in three dimensions in ten dogs.</AbstractText>Thrombotic occlusion was induced using a wire to deliver current to the proximal left circumflex artery (LCX). In nine dogs, nonsustained VT (NSVT) arose fro... |
4,568 | Analysis of the pattern of initiation of sustained ventricular arrhythmias in patients with implantable defibrillators. | The purpose of this study was to analyze the pattern of initiation of sustained ventricular arrhythmias in patients with varying types of underlying structural heart disease.</AbstractText>The study group consisted of 90 patients with an implantable cardioverter defibrillator. Cardiovascular diagnoses included coronary... |
4,569 | Intravenous amiodarone for prevention of atrial fibrillation after coronary artery bypass grafting. | Atrial fibrillation occurs in 10% to 40% of patients who undergo coronary artery bypass grafting. This prospective study assesses the safety and efficacy of low-dose intravenous amiodarone in the prevention of atrial fibrillation after coronary artery bypass grafting.</AbstractText>One hundred forty patients were rando... |
4,570 | Prophylaxis of supraventricular and ventricular arrhythmias after coronary artery bypass grafting with low-dose sotalol. | Supraventricular tachyarrhythmia (SVT) commonly occurs shortly after coronary artery bypass grafting (CABG), but ventricular arrhythmias are less documented.</AbstractText>On the 1st postoperative day, 206 consecutive eligible patients were prospectively randomized to a sotalol group (80 mg b.i.d.; n = 103) or a contro... |
4,571 | End-tidal carbon dioxide as a noninvasive indicator of cardiac index during circulatory shock. | To document the relationships between cardiac index and end-tidal carbon dioxide tension (PetCO2 during diverse low-flow states of circulatory shock.</AbstractText>Randomized, prospective, controlled studies on animal models of hemorrhagic, septic, and cardiogenic shock.</AbstractText>University-affiliated research lab... |
4,572 | Cardiopulmonary resuscitation of older, inhospital patients: immediate efficacy and long-term outcome. | To determine the independent effect of advancing age on prognosis after cardiopulmonary resuscitation (CPR).</AbstractText>Retrospective analysis of clinical records of patients who received CPR in a geriatric department equipped with an intensive care unit.</AbstractText>A total of 245 patients (146 men, 99 women; mea... |
4,573 | [Prevention of cardiovascular disease in the elderly]. | PREVENTION OF STROKE: Several preventive strategies have been found to be effective for the prevention of stroke in elderly subjects, including treatment of high blood pressure, oral anticoagulants in case of atrial fibrillation, aspirin for subjects at risk. PREVENTION OF MYOCARDIAL INFARCTION: Anti-hypertension treat... |
4,574 | Pitfalls of the concept of incremental specificity used in comparisons of dual chamber VT/VF detection algorithms. | The concepts of incremental specificity and incremental positive predictive accuracy (PPA) have been proposed to measure the success of dual chamber cardioverter defibrillator (ICD) algorithms for tachyarrhythmia detection in improving specificity while maintaining very high sensitivity to detection of episodes of vent... |
4,575 | P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation. | The prolongation of intraatrial and interatrial conduction time and the inhomogeneous propagation of sinus impulses have been shown in patients with atrial fibrillation. Recently P wave dispersion (PWD), which is believed to reflect inhomogeneous atrial conduction, has been proposed as being useful for the prediction o... |
4,576 | High rate atrial tachyarrhythmia detections in implantable pulse generators: low incidence of false-positive detections. The PA Clinical Trial Investigators. | Some newer pulse generators have enhanced diagnostic features that provide information on the frequency, date, time of onset, and duration of atrial and/or ventricular tachyarrhythmias. However, the sensitivity and specificity of device-based atrial tachyarrhythmia detections may vary and depend, in part, on lead posit... |
4,577 | [Digitalis intoxication during the neonatal period: role of dehydration]. | Despite the great progress which has been made in the treatment of acute digitalis intoxication by digoxin-immune Fab, it still remains a severe complication of cardiotonic therapy.</AbstractText>A neonate with ventricular septal defect and large left-to-right shunt was treated with digitalis and diuretics at the usual... |
4,578 | [Utilization of implantable ventricular defibrillators (with an analysis of the value of antiarrhythmics in the treatment of potentially fatal ventricular arrhythmias]. | During the past 15 years, the efficacy of antiarrhythmic drugs has been investigated for reducing sudden cardiac death in patients at high risk of arrhythmia. Whereas the benefits of beta-blocker therapy are well established, a reduction in mortality with other antiarrhythmic drugs remains unproved and in some cases, t... |
4,579 | Life threatening coronary artery spasm in childhood Kimura's disease. | A 13 year old boy is described with hypereosinophilia associated with Kimura's disease, who showed repeated life threatening syncopal attacks during daily activities or at rest. Coronary arteriography demonstrated small aneurysms with irregular vessel walls of both coronary arteries, and the absence of organic stenotic... |
4,580 | The role of beta-blockers in preventing sudden death in heart failure. | Sudden death accounts for one third to one half of the deaths in patients with heart failure. Recent studies using beta-adrenergic blockers in patients with reduced systolic function and heart failure symptoms have shown significant reductions in overall mortality rates. This article discusses the role of beta-blockers... |
4,581 | Atrium as a source of brain natriuretic polypeptide in patients with atrial fibrillation. | Plasma brain natriuretic polypeptide (BNP) levels have been used as biochemical markers of systolic left ventricular (LV) dysfunction. Although in vitro studies have shown the existence of BNP messenger RNA in the atria, the main production site of BNP is believed to be the ventricle. The hypothesis that the atrium cou... |
4,582 | Electrophysiological changes of angiotensin-converting enzyme inhibition after myocardial infarction. | To investigate whether prevention of remodeling would translate into a more stable electrophysiological profile, the investigators randomized 56 patients to treatment with angiotensin-converting enzyme (ACE) inhibition or placebo for 3 months after myocardial infarction. Programmed electrical stimulation revealed no si... |
4,583 | Bone marrow granulomas possibly associated with amiodarone. | Amiodarone is a class III antiarrhythmic agent that is effective in treating different types of cardiac dysrhythmias. It was approved only for treatment of life-threatening ventricular dysrhythmias refractory to other therapy; however, its use for atrial dysrhythmias such as atrial fibrillation is well accepted. Advers... |
4,584 | Dofetilide, a new class III antiarrhythmic agent. | Dofetilide is a new antiarrhythmic agent recently approved for conversion and maintenance of sinus rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFl). It is a class III antiarrhythmic that works by selectively blocking the rapid component of the delayed rectifier outward potassium current. Dofeti... |
4,585 | Prediction of major arrhythmic events and sudden cardiac death in dilated cardiomyopathy. The Marburg Cardiomyopathy Study design and description of baseline clinical characteristics. | The Marburg Cardiomyopathy Study (MACAS) is a prospective observational study designed to determine the value of the following potential non-invasive arrhythmia risk predictors in more than 200 patients with idiopathic dilated cardiomyopathy (IDC) over a 5-year follow-up period: New York Heart Association functional cl... |
4,586 | Effects on infarct size and on arrhythmias by controlling reflow after myocardial ischaemia in pigs. | Part of the myocardial damage after an ischaemic period might be related to the reperfusion conditions. Many abrupt changes occurring in the heart during reperfusion may add to the damage during the preceding ischaemic period, and increase in infarct size. In this study we tested the hypothesis that infarct size and oc... |
4,587 | Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study. | To characterise the clinical features of patients with suspected heart failure but preserved left ventricular systolic function to determine if they have other potential causes for their symptoms rather than being diagnosed with "diastolic heart failure."</AbstractText>Prospective descriptive study.</AbstractText>Outpa... |
4,588 | Suicide by ingestion of a CCA wood preservative. | Chromated-copper-arsenate (CCA) is a compound used worldwide for wood preservation. Occupational hazards from chronic exposure to CCA are well known, but acute ingestion of CCA wood preservative is very rare. We describe a case of suicide by ingestion of a CCA wood preservative. A 33-year-old man attempted suicide by i... |
4,589 | Prospective study of early discharge after acute myocardial infarction (SHORT). | To identify, without additional investigation, a large group of myocardial infarction patients at low risk who would qualify for early discharge.</AbstractText>The decision rule was developed in 647 unselected patients with consecutively admitted myocardial infarction, and validated in 825 others. Daily event-rates wer... |
4,590 | Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury. | During postischemic reperfusion, free radicals are produced and have deleterious effects in isolated rat hearts. We investigated whether melatonin (MEL) reduces the production of hydroxyl radical (*OH) in the effluent and aids in recovery of left ventricular (LV) function. Hearts were subjected to 30 min of ischemia fo... |
4,591 | Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. | We examined the role of the sarcolemmal and mitochondrial ATP-sensitive potassium (K(ATP)) channel in a rat model of myocardial infarction after stimulation with the selective delta(1)-opioid receptor agonist TAN-67. Hearts were subjected to 30 min of regional ischemia and 2 h of reperfusion. Infarct size was expressed... |
4,592 | Homozygotes for a R869G mutation in the beta -myosin heavy chain gene have a severe form of familial hypertrophic cardiomyopathy. | Familial Hypertrophic Cardiomyopathy (FHC) is an autosomal dominant disease characterised by ventricular hypertrophy, with predominant involvement of the interventricular septum. It is a monogenic disease with a high level of genetic heterogeneity (nine genes and more than 110 mutations reported so far). We describe a ... |
4,593 | Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium. | During atrial fibrillation, ventricular rate is determined by atrioventricular nodal (AVN) conduction, which in part is dependent upon the refractoriness of single AVN cells. The aims of this study were to investigate the rate-dependency of the action potential duration (APD) and effective refractory period (ERP) in si... |
4,594 | Reduced ventricular response irregularity is associated with increased mortality in patients with chronic atrial fibrillation. | BACKGROUND-Variations in the ventricular response interval (VRI) during atrial fibrillation (AF) may be reduced in patients with adverse clinical outcomes. The properties of VRI dynamics associated with prognosis remain undetermined. METHODS AND RESULTS-In 107 patients with chronic AF (age, 64+/-9 years), we analyzed a... |
4,595 | Increased sympathetic activity after atrioventricular junction ablation in patients with chronic atrial fibrillation. | The aim of this study was to determine the changes in sympathetic nerve activity (SNA) after atrioventricular junction (AVJ) ablation in patients with chronic atrial fibrillation (AF).</AbstractText>Polymorphic ventricular tachycardia (PMVT) has been reported after AVJ ablation in patients paced at a rate of < or =7... |
4,596 | [Aortic valve replacement for aortic valve stenosis due to congenital bicuspid aortic valve with abnormal positioning of coronary orifice, pseudotendon, and persistent left superior vena cava, report of a case]. | A patient was a 65-year-old female who had a complaint of palpitation was diagnosed aortic valve stenosis due to congenital bicuspid aortic valve with pseudotendon by the echocardiographic examination. We suspected left single coronary artery by the aortography and the coronary artery angiography. Aortic valve replacem... |
4,597 | [A case of aconitine poisoning saved with cardiopulmonary bypass]. | "Torikabuto" is a kind of plant which contains deadly poison. Its ingredient is aconitine alkaloids. We report a case of aconitine poisoning with fatal arrhythmia and acute pulmonary edema who was saved with cardio pulmonary bypass. A 41-year-old male ate to mistake "Torikabuto" for wild plant. He developed symptoms of... |
4,598 | Phase II study of paclitaxel and epirubicin as first-line treatment in patients with metastatic nonsmall cell lung carcinoma. | The combination of paclitaxel and epirubicin has shown a favorable interaction in patients with advanced breast carcinoma. Therefore the efficacy and toxicity of this regimen was evaluated in a Phase II study of patients with metastatic nonsmall cell lung carcinoma (NSCLC).</AbstractText>Thirty-two chemotherapy-naive p... |
4,599 | Amiodarone for rapid cardioversion of chronic atrial tachyarrhythmia? | Electrical cardioversion of atrial tachyarrhythmia has disadvantages, such as the need for general anaesthesia, skin burns and thoracic pain. Pharmacodynamic cardioversion is without these side effects, but the reports of the efficacy of the treatment vary a lot. Amiodarone has been the only drug so far reported to giv... |
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