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5,000 | [Study on ultrastructure of cardioprotection of ramipril against ischemia/reperfusion injury in diabetic rats]. | To investigate the effects of ramipril on myocardial ischemia/reperfusion injury in diabetic rats, and to explore its mechanism according to the observation on myocardial ultrastructure.</AbstractText>Streptozotocin induced diabetic rats were divided randomly into three groups (n = 16): ischemia/reperfusion (I/R), isch... |
5,001 | Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling. | Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated rabbit hearts ... |
5,002 | Comparison of a novel, single-lead atrial sensing system with a dual-chamber implantable cardioverter-defibrillator system in patients without antibradycardia pacing indications: results of a randomized study. | Supraventricular tachyarrhythmias are the main cause for inappropriate therapy by implantable cardioverter-defibrillators (ICDs). For better rhythm discrimination, an atrial electrogram is helpful and usually obtained from an additional atrial lead, even in the absence of sinus node or atrioventricular nodal disease. A... |
5,003 | Isoproterenol administration during general anesthesia for the evaluation of children with ventricular preexcitation. | Rapid anterograde conduction in the setting of ventricular preexcitation is associated with an increased risk of sudden cardiac death. The effect of isoproterenol in this setting is unclear, particularly in younger anesthetized patients. The aim of this study was to determine the effect of isoproterenol on accessory-pa... |
5,004 | Effects of a highly selective acetylcholine-activated K+ channel blocker on experimental atrial fibrillation. | The acetylcholine-activated K(+) current (I(K,ACh)) is a novel candidate for atrial-specific antiarrhythmic therapy. The present study investigates the involvement of I(K,ACh) in atrial fibrillation (AF) using NTC-801, a novel potent and selective I(K,ACh) blocker.</AbstractText>The effects of NTC-801, substituted 4-(a... |
5,005 | Predictors of electrical storm recurrences in patients with implantable cardioverter-defibrillators. | To determine prevalence and predictors of electrical storm recurrences (ES-Rs) in patients with implantable cardioverter-defibrillators (ICDs) as electrical storms (ESs) represent serious clinical events carrying a high risk of mortality.</AbstractText>Single-centre study analysing data of consecutive patients receivin... |
5,006 | Noninvasive computational imaging of cardiac electrophysiology for 3-D infarct. | Myocardial infarction (MI) creates electrophysiologically altered substrates that are responsible for ventricular arrhythmias, such as tachycardia and fibrillation. The presence, size, location, and composition of infarct scar bear significant prognostic and therapeutic implications for individual subjects. We have dev... |
5,007 | Atrial Tachycardia Successfully Ablated from the Left Coronary Sinus Cusp of the Aorta: An Unusual Site of Origin. | It has been recognized in the last decade that atrial and ventricular tachycardias may arise from the myocardium around the aorta. These tachycardias can be ablated from the coronary sinus cusps of the aorta (ASCs) . In some of those tachycardias, the site of origin may be epicardial and thus can be ablated only throug... |
5,008 | Poor tolerance of beta-blockers by elderly patients with heart failure. | Despite the well-understood importance of beta-blocker therapy in heart failure, it is sometimes not possible to use beta-blockers in elderly patients due to poor tolerance. In this report, we describe the case of an 83-year-old patient with severe systolic heart failure complicated by aortic valve stenosis and atrial ... |
5,009 | A comparison of long-standing implantable cardioverter-defibrillator patients with and without appropriate therapy for ventricular arrhythmias: impact of a widening QRS. | The comparison of patients with long-standing implantable cardioverter-defibrillators (ICDs) who have had or never have had appropriate therapy for ventricular arrhythmias may offer insight into potential risk factors that may improve patient selection.</AbstractText>Records from patients in the Columbia Presbyterian d... |
5,010 | Rate-dependent shortening of action potential duration increases ventricular vulnerability in failing rabbit heart. | Congestive heart failure (CHF) predisposes to ventricular fibrillation (VF) in association with electrical remodeling of the ventricle. However, much remains unknown about the rate-dependent electrophysiological properties in a failing heart. Action potential properties in the left ventricular subepicardial muscles dur... |
5,011 | Ajmaline challenge for the diagnosis of Brugada syndrome: which protocol? | Ajmaline challenge is commonly used for the diagnosis of Brugada syndrome. A slow infusion rate has been recommended in view of the proarrhythmic risk, but the diagnostic value of various infusion rates has not been investigated.</AbstractText>To compare rapid and slow ajmaline infusion rates and to assess the proarrhy... |
5,012 | Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes. | Stress cardiomyopathy (SCM) is a syndrome of transient ventricular dysfunction triggered by severe emotional or physical stress, likely resulting from catecholamine-mediated myocardial toxicity. Repolarization abnormalities associated with other hyperadrenergic states can cause QT prolongation and lethal arrhythmia inc... |
5,013 | Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. | T-wave alternans may predict the occurrence of ventricular arrhythmias in patients with left ventricular dysfunction and experimental work has linked discordant repolarization alternans to the induction of re-entry. The aim of this study was to examine the occurrence of transmural repolarization alternans and to invest... |
5,014 | Atrial protective effects of n-3 polyunsaturated fatty acids: a long-term study in ovine chronic heart failure. | It has been suggested that omega-3 polyunsaturated fatty acids (n-3 PUFAs) may prevent the development of atrial fibrillation (AF).</AbstractText>The purpose of this study was to evaluate the impact of these agents on development of the AF substrate in heart failure (HF).</AbstractText>In this study, HF was induced by ... |
5,015 | Detection of ventricular ectopy by a novel miniature electrocardiogram recorder. | The ability of a miniaturized, skin-attached, 3-channel electrocardiogram (ECG) recorder prototype to detect ventricular ectopic beats (VEBs) and ventricular fibrillation (VF) was compared with that of standard Holter ECG.</AbstractText>Concurrent 15-hour ECG recordings were made in 143 patients using an experimental d... |
5,016 | Crossing over to the other side. | What happened when a doctor on duty in the emergency department suddenly made the transition to "patient in Resus 2"? |
5,017 | Use of implantable cardioverter-defibrillators. | The implantable cardioverter-defibrillator (ICD) is the most effective treatment for patients with life-threatening ventricular tachycardia or ventricular fibrillation not due to reversible causes. The American College of Cardiology/American Heart Association class I and IIa indications for an ICD are discussed. Patien... |
5,018 | Heart failure with preserved left ventricular ejection fraction: concepts, misconceptions and future directions. | Heart failure with preserved left ventricular ejection fraction (HFPEF) represents a huge medical problem, especially in light of an increasing elderly population. Dysfunction of both left ventricular filling and ejection, combined with adverse loading conditions related to advanced age, arterial hypertension, diabetes... |
5,019 | Intracoronary administration of bone marrow-derived mononuclear cells and arrhythmic events in patients with chronic heart failure. | There are continued debates on potential proarrhythmic effects of intracoronary bone marrow-derived progenitor cell (BMC) therapy for treatment of chronic heart failure. Implantable cardioverter-defibrillators (ICDs), a mainstay of heart failure therapy, provide the possibility of validly assessing arrhythmias in patie... |
5,020 | Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. | Atrial fibrillation (AF) is the most common arrhythmia in clinical practise and its prevalence is increasing. Over the last 25 years, flecainide has been used extensively worldwide, and its capacity to reduce AF symptoms and provide long-term restoration of sinus rhythm (SR) has been well documented. The increased mort... |
5,021 | Cardiac resynchronization therapy: current trends and future directions. | Despite the clear cut indications for cardiac resynchronization therapy (CRT) laid down by guideline forming bodies, there are numerous unresolved issues. This review article primarily focuses on the current trends in CRT and the challenges encountered in patient selection, procedure related and postimplantation patien... |
5,022 | Management of ventricular arrhythmias. | Underlying causes of ventricular tachycardia (VT) or complex ventricular arrhythmias (VA) should be treated if possible. Anti-arrhythmic drugs should not be used to treat asymptomatic patients with complex VA and no heart disease. Beta blockers are the only antiarrhythmic drugs that have been documented to reduce morta... |
5,023 | Value of robotic navigation and ablation. | Catheter ablation has been established as a potentially curative treatment modality for various arrhythmias. Over the past years, catheter ablation has progressed from focal ablation to complex ablations within a three-dimensional anatomy for the treatment of ventricular tachycardia or atrial fibrillation. Complex abla... |
5,024 | Advances in the treatment of atrial fibrillation. | Management of atrial fibrillation (AF) has changed greatly in the past 10 years. The advent of a greater understanding of the pathophysiology of AF has resulted in major therapeutic breakthroughs, both in invasive and non-invasive strategies. New antiarrhythmic agents with fewer side effects, new anticoagulants and tec... |
5,025 | Autonomic denervation with magnetic nanoparticles. | prior studies indicated that ablation of the 4 major atrial ganglionated plexi (GP) suppressed atrial fibrillation.</AbstractText>superparamagnetic nanoparticles (MNPs) made of Fe(3)O(4) (core), thermoresponsive polymeric hydrogel (shell), and neurotoxic agent (N-isopropylacrylamide monomer [NIPA-M]) were synthesized. ... |
5,026 | Differences in myocardial structure and coronary microvasculature between men and women with coronary artery disease. | Women younger than 75 years with stable angina or acute coronary syndrome have higher cardiac mortality than similarly aged men, despite less obstructive coronary artery disease. To determine whether the myocardial structure and coronary microvasculature of women differs from that of men, we performed histological anal... |
5,027 | Mitral valve prolapse and out-of-hospital sudden death: a case report and literature review. | The emergency medical services were called to the workplace of a 25-year-old woman who appeared to be dead. The alarm was raised by employees who had found her unconscious at her desk. There was no semi-automatic defibrillator on the premises and no member of staff had received specific training in management of cardia... |
5,028 | Comparison of effectiveness of carvedilol versus bisoprolol for prevention of postdischarge atrial fibrillation after coronary artery bypass grafting in patients with heart failure. | Atrial fibrillation (AF) occurs frequently soon after coronary artery bypass grafting (CABG) and often results in increased mortality and morbidity, particularly in patients with heart failure. New-onset AF is also a common event in the early period after discharge from a cardiac surgery clinic. Current guidelines reco... |
5,029 | Efficacy of fluid assessment based on intrathoracic impedance monitoring in patients with systolic heart failure. | Previous studies have demonstrated that intrathoracic impedance monitoring (IIM) is associated with fluid overload. However, it remains unclear whether this new technology can predict heart failure (HF) before deterioration. Whether fluid status based on IIM predicts HF in patients with left ventricular (LV) systolic d... |
5,030 | Marked variability in susceptibility to ventricular fibrillation in an experimental commotio cordis model. | Precordial blows in sports and daily activities can trigger ventricular fibrillation (VF) (commotio cordis). Whereas chest wall blows are common, commotio cordis is rare. Although factors such as timing, location, orientation, and energy of impact are critically important, we also hypothesize that there is individual s... |
5,031 | Congestive heart failure and atrial fibrillation in a cat with myocardial fibro-fatty infiltration. | Congestive heart failure and atrial fibrillation were diagnosed in a 4-year-old castrated Birman cat with progressive signs of dyspnea, tachypnea, and lethargy. Echocardiography revealed massive right-sided heart dilatation with ascites and hydrothorax. Electrocardiogram recording showed atrial fibrillation. Medical th... |
5,032 | The persistent sodium current blocker riluzole is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarction. | The potential of the cardiac persistent sodium current as a target for protection of the myocardium from ischaemia and reperfusion injury is gaining increasing interest. We have investigated the anti-ischaemic and antiarrhythmic effects of riluzole, a selective INaP blocker, in an open chest pig model of infarction.</A... |
5,033 | Tetralogy of fallot repair in patients 40 years or older. | To report the outcomes of patients with tetralogy of Fallot (TOF) undergoing surgical repair at age 40 years or older.</AbstractText>We reviewed records of patients (age, ≥40 years) who underwent TOF repair from January 1, 1970, through December 31, 2007. Symptoms, palliative procedures, surgical reports, and lo... |
5,034 | [The effects on brain function and ultrastructure changes by elevating mean arterial pressure after cardio-pulmonary resuscitation in pigs]. | To investigate the effects on brain function and ultrastructure changes by elevating mean arterial pressure (MAP) with norepinephrine after cardiopulmonary resuscitation (CPR) in pigs.</AbstractText>After 4 minutes of untreated ventricular fibrillation, CPR was begun in 10 piglets, followed by defibrillation. Following... |
5,035 | Short QT Syndromes. | The short QT syndrome is a recently described genetic arrhythmogenic disorder, characterized by abnormally short QT intervals and a high incidence of sudden death and atrial fibrillation. Clinical manifestations may also be present in infants; a family history of cardiac sudden death is often present. Gain-of-function ... |
5,036 | Brugada Syndrome 2010. | The Brugada syndrome is a genetically determined cardiac disorder, presenting with characteristic electrocardiogram features and high risk of sudden cardiac death from polymorphic ventricular tachycardia/ventricular fibrillation in young individuals with a structurally normal heart. Scientific knowledge about the disea... |
5,037 | Hemodynamic support with TandemHeart in tako-tsubo cardiomyopathy - a case report. | Tako-tsubo cardiomyopathy is characterized by chest pain, electrocardiographic abnormalities mimicking acute myocardial infarction, akinesis or dyskinesis of apical or mid left ventricular segments, and the absence of obstructive coronary artery disease. Tako-tsubo cardiomyopathy is usually a potentially reversible for... |
5,038 | Persistent atrial fibrillation is not associated with thrombomodulin level increase in efficiently anticoagulated patients. | Atrial fibrillation (AF) is the most common arrhythmia and leads to a five-fold increased risk of stroke compared to persons with sinus rhythm. A soluble form of thrombomodulin (sTM) is a recognized marker of endothelial dysfunction and may contribute to the hypercoagulable state in AF. The aim of the study was to eval... |
5,039 | Tachycardia transition during ablation of persistent atrial fibrillation. | The "sequential ablation" strategy for persistent AF is aimed at progressive organization of AF until the rhythm converts to sinus rhythm or atrial tachycardia (AT). During ablation of an AT, apparently seamless transitions from one organized AT to another occur. The purpose of our study was to quantify the occurrence ... |
5,040 | A review of the appropriate and inappropriate use of dronedarone: lessons learned from controlled studies and regulatory submission. | Dronedarone is a multichannel blocker with electrophysiologic effects similar to amiodarone. Dronedarone has been documented to prevent atrial fibrillation recurrences and also has efficacy in slowing the ventricular response during episodes of atrial fibrillation. However, in the ANDROMEDA trial, dronedarone was assoc... |
5,041 | A new agent for atrial fibrillation: electrophysiological properties of dronedarone. | Although originally synthesized as an antianginal compound, amiodarone has emerged as an effective antiarrhythmic for both supraventricular and ventricular arrhythmias. Over the decades, the properties, the effectiveness, the merits as well as the shortcomings of the compound have been well established. The major limit... |
5,042 | Prompt prediction of successful defibrillation from 1-s ventricular fibrillation waveform in patients with out-of-hospital sudden cardiac arrest. | Ventricular fibrillation (VF) is a common cardiac arrest rhythm that can be terminated by electrical defibrillation. During cardiopulmonary resuscitation, there is a strong need for a prompt and reliable predictor of successful defibrillation because myocardial damage can result from repeated futile defibrillation atte... |
5,043 | [Class I antiarrhythmic drugs: mechanisms, contraindications, and current indications]. | Class I antiarrhythmic drugs are sodium channel inhibitors that act by slowing myocardial conduction and, thus, interrupting or preventing reentrant arrhythmia. Due to proarrhythmic effects and the risk of ventricular tachyarrhythmia, class I antiarrhythmics should not be administered in patients with structural heart ... |
5,044 | Long-term follow-up of patients with myotonic dystrophy: an electrocardiogram every year is not necessary. | A high risk of arrhythmias was reported in myotonic dystrophy (MD). The purpose of the study was to evaluate the value of non-invasive and invasive investigations for the arrhythmias detection and when to repeat the investigations. 129 patients, mean age 41 ± 14 years, with MD, were asymptomatic, except 4. Electro... |
5,045 | Adverse experiences with implantable defibrillators in Oregon hospices. | Implantable cardioverter-defibrillators (ICDs) improve survival in patients at risk for recurrent, sustained ventricular tachycardia or fibrillation. Unless deactivated, ICDs may deliver unwanted shocks to terminally ill patients near the time of death. This study sought to determine the frequency and nature of adverse... |
5,046 | Equitable improvement for women and men in the use of guideline-recommended therapies for heart failure: findings from IMPROVE HF. | Although sex-based disparities in use of guideline-recommended heart failure (HF) therapies have been described, little is known about whether performance improvement (PI) initiatives produce equitable improvements in guideline-recommended therapies.</AbstractText>IMPROVE HF is a prospective study of a practice-based P... |
5,047 | Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly) score. | The purpose of this study was to investigate predictors of bleeding in a cohort of anticoagulated patients and to evaluate the predictive value of several bleeding risk stratification schemas.</AbstractText>The risk of bleeding during antithrombotic therapy in patients with atrial fibrillation (AF) is not homogeneous, ... |
5,048 | A slightly elevated level of N-terminal pro-brain natriuretic peptide can predict coronary artery disease in a population with normal left ventricular function. | The prognostic and diagnostic values of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in ischemic heart disease have already been investigated in many previous studies. Although NT-pro-BNP is affected by many factors, these previous studies did not strictly exclude them. This study included 110 patients who rec... |
5,049 | Shortening of paced QRS complex and clinical improvement following upgrading from apical right ventricular pacing to bifocal right ventricular or biventricular pacing in patients with permanent atrial fibrillation. | Cardiac resynchronisation therapy (CRT) using biventricular pacing (BVP) has been shown to improve survival in patients with chronic heart failure (CHF). However, BVP cannot be achieved in all patients because of technical problems. In such patients, bifocal right ventricular pacing (BFP) may be an alternative.</Abstra... |
5,050 | [New developments in the antiarrhythmic therapy of atrial fibrillation]. | Atrial fibrillation, which is associated with a worsening of congestive heart failure symptoms, an increased rate of stoke, and increased mortality, is still difficult to treat. New therapies must not only increase effectiveness, but also have to have an improved safety profile, in order to avoid sodium channel block i... |
5,051 | Changes in cytokine concentrations following successful ablation of atrial fibrillation. | Atrial fibrillation is associated with the activation of inflammatory processes [e.g. higher concentrations of pro-inflammatory cytokines interleukin-6 (IL-6), C-reactive protein (CRP)], as well as a pro-thrombotic state [e.g. increased concentration of serum pro-thrombotic markers P-selectin and CD40 ligand (CD40L)]. ... |
5,052 | [Antiarrhythmic therapy with β-receptor antagonists]. | β-Blockers are an essential component of medical therapy in patients with ischemic heart disease or cardiac dysfunction of any genesis. They have an effect at the level of the sinus and the atrioventricular node, as well as on the atrial and ventricular refractory period of the myocardium. Overall, there are comp... |
5,053 | [Current role of amiodarone in antiarrhythmic therapy]. | Decades after its registration, amiodarone is still regarded as the most effective antiarrhythmic drug available for the treatment of tachyarrhythmias. Amiodarone is classified as a class III antiarrhythmic drug. In addition to the prolongation of cardiac repolarization, its leading pharmacologic features are sodium an... |
5,054 | Cardiovascular implications in the treatment of obstructive sleep apnea. | Epidemiological studies provide strong evidence that obstructive sleep apnea (OSA) is associated with cardiovascular complications such as systemic hypertension, congestive heart failure, and atrial fibrillation. Successful OSA treatment with continuous positive airway pressure (CPAP) has resulted in coincident reducti... |
5,055 | Coronary-artery spasm after coronary artery bypass graft surgery without extracorporeal circulation: diagnostic and management. | Coronary artery spasm in perioperative of coronary artery bypass graft surgery is a serious complication, with high rate mortality. Patient 51 years-old submitted to coronary artery bypass graft surgery without Extracorporeal Circulation. The patient evolved in 1st post operative (PO) day with enzymatic alteration and ... |
5,056 | Transmural dispersion of repolarization determines scroll wave behavior during ventricular tachyarrhythmias. | Ventricular tachyarrhythmia is the leading cause of sudden cardiac death, and scroll wave re-entry is known to underlie this condition. Class III antiarrhythmic drugs are commonly used worldwide to treat ventricular tachyarrhythmias; however, these drugs have a proarrhythmic adverse effect and can cause Torsade de Poin... |
5,057 | Long-term results of catheter ablation in paroxysmal atrial fibrillation: lessons from a 5-year follow-up. | Paroxysmal atrial fibrillation (AF) naturally progresses toward chronic AF at an estimated rate of 15% to 30% over a 1- to 3-year period. Pulmonary vein (PV) isolation is increasingly performed for the treatment of drug-refractory paroxysmal AF. The long-term data on clinical outcome after circumferential PV isolation ... |
5,058 | MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation. | A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca(2+) current and shortening of the action potential duration. The possibility that microRNAs (miRNAs) may be involved in this process has not been tested. Accordingly,... |
5,059 | Diagnosis of cardiovascular abnormalities from compressed ECG: a data mining-based approach. | Usage of compressed ECG for fast and efficient telecardiology application is crucial, as ECG signals are enormously large in size. However, conventional ECG diagnosis algorithms require the compressed ECG packets to be decompressed before diagnosis can be performed. This added step of decompression before performing di... |
5,060 | Distinguishing between ventricular tachycardia and ventricular fibrillation from compressed ECG signal in wireless Body Sensor Networks. | Since ECG is huge in size sending large volume data over resource constrained wireless networks is power consuming and will reduce the energy of nodes in Body Sensor Networks (BSN). Therefore, compression of ECGs and diagnosis of diseases from compressed ECGs will play key roles in enhancing the life-time of body senso... |
5,061 | Prediction of ventricular fibrillation based on the ST-segment deviation: allometric model. | Based on some reported clinical data, we attempt to apply the allometric law for evaluating the probability of ventricular fibrillation when electrocardiographic ST-segment deviations are determined. The deviation is measured in millimeters at the standard calibration of 1mV = 10mm and the probability in percent. Using... |
5,062 | Influences of sites and protocols on inducing ventricular fibrillation: A computer simulation study. | In cardiac electrophysiological study, several electrical stimulation protocols have been employed to induce ventricular fibrillations (VF). In addition, sites of inducing may have different impacts on inducing results as well as different inducing protocols. To study whether VF inducing method is determinant of induce... |
5,063 | Wavelet-based markers of ventricular fibrillation in optimizing human cardiac resuscitation. | During cardiac resuscitation from ventricular fibrillation (VF) it would be helpful if we could monitor and predict the optimal state of the heart to be shocked into a perfusing rhythm. Real-time feedback of this state to the emergency medical staff (EMS) could improve the survival rate after resuscitation. In this pap... |
5,064 | A fast critical arrhythmic ECG waveform identification method using cross-correlation and multiple template matching. | Critical Arrhythmic ECG such as Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF) are both distinguishable by its waveform characteristics. A VF waveform is often described as disorganized and has an irregular rhythm while a VT waveform exhibits abnormal signatures and presents a regular rhythm pattern. Th... |
5,065 | A novel mechanism for electrical currents inducing ventricular fibrillation: The three-fold way to fibrillation. | It has been long recognized that there are 2 methods for inducing VF (ventricular fibrillation) with electrical currents‥ These are: (1) delivering a high-charge shock into the cardiac T-wave, and (2) delivering lower level currents for 1-5 seconds. Present electrical safety standards are based on this understan... |
5,066 | Wireless transmission of cardiac action potentials with ultrasonically guided insertion of silicon probes. | This paper reports on the coupling of ultrasonically guided cardiac probes with wireless transmission of cardiac action potentials for applications in monitoring the 3D electrical onset of ventricular fibrillation. An application specific integrated circuit has been designed with a 40 dB amplifying stage and a frequenc... |
5,067 | ECG Data-Acquisition and classification system by using wavelet-domain Hidden Markov Models. | This article is concerned with the classification of ECG pulses by using state of the art Continuous Density Hidden Markov Models (CDHMM's). The ECG signal is simultaneously observed at three different level of focus by means of the Wavelet Transform (WT). The types of beat being selected are normal (N), premature vent... |
5,068 | Functional model of dual AV nodal pathway physiology. | Role of dual AV nodal pathway physiology in the atrioventricular nodal (AVN) conduction during atrial arrhythmias remains unclear. By using His electrogram alternans (HEA), we have developed a functional model of the atrioventricular conduction that incorporates the dual AV nodal pathway physiology. Experiments perform... |
5,069 | Shock-induced arrhythmogenesis in the human heart: A computational modelling study. | Electrical defibrillation by application of a strong shock to the heart is the only effective treatment against lethal cardiac arrhythmias such as ventricular fibrillation. A large body of experimental and computational research has been devoted to understanding shock-induced effects on the heart in an attempt to impro... |
5,070 | Echocardiographic left atrial reverse remodeling after catheter ablation of atrial fibrillation is predicted by preablation delayed enhancement of left atrium by magnetic resonance imaging. | Atrial fibrosis is a hallmark of atrial structural remodeling (SRM) and leads to structural and functional impairment of left atrial (LA) and persistence of atrial fibrillation (AF). This study was conducted to assess LA reverse remodeling after catheter ablation of AF in mild and moderate-severe LA SRM.</AbstractText>... |
5,071 | Can an elderly woman's heart be too strong? Increased mortality with high versus normal ejection fraction after an acute coronary syndrome. The Global Registry of Acute Coronary Events. | Coronary artery disease is the leading cause of death in women. We sought to validate previous clinical experience in which we have observed that elderly women with a very high left ventricular ejection fraction (LVEF) are at increased risk of death compared with elderly women with acute coronary syndromes with a norma... |
5,072 | Onset dynamics of ventricular tachyarrhythmias as measured by dominant frequency. | Differences in dominant frequency (DF), a measure of electrical activation rate, were used to characterize and classify ventricular tachyarrhythmias (VTA) at onset.</AbstractText>In canine 3- to 5-day-old infarct border zone, monomorphic re-entrant ventricular tachycardia (MVT) was repeatedly induced by programmed elec... |
5,073 | Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model. | Clinical evidence suggests that the antianginal agent ranolazine has antiarrhythmic properties, but its effects on vulnerability to ventricular fibrillation (VF) and T-wave alternans (TWA) during coronary artery stenosis have not been measured.</AbstractText>We investigated whether the antiarrhythmic effect of ranolazi... |
5,074 | Effect of amiodarone-induced hyperthyroidism on left ventricular outflow obstruction after septal myectomy for hypertrophic cardiomyopathy. | Patients with obstructive hypertrophic cardiomyopathy who undergo septal myectomy are at risk for developing postoperative atrial fibrillation. Amiodarone is effective in treating this arrhythmia but is associated with multiple adverse effects, often with delayed onset. A novel case is described of a patient who develo... |
5,075 | Effect of combined spironolactone-β-blocker ± enalapril treatment on occurrence of symptomatic atrial fibrillation episodes in patients with a history of paroxysmal atrial fibrillation (SPIR-AF study). | Angiotensin II and aldosterone are key factors responsible for the structural and neurohormonal remodeling of the atria and ventricles in patients with atrial fibrillation (AF). The aim of the present study was to evaluate the antiarrhythmic effects of spironolactone compared to angiotensin-converting enzyme inhibitors... |
5,076 | A new electrocardiogram marker to identify patients at low risk for ventricular tachyarrhythmias: sum magnitude of the absolute QRST integral. | We proposed and tested a novel electrocardiogram marker of risk of ventricular arrhythmias (VAs).</AbstractText>Digital orthogonal electrocardiograms were recorded at rest before implantable cardioverter-defibrillator (ICD) implantation in 508 participants of a primary prevention ICDs prospective cohort study (mean &#x... |
5,077 | The incidence and prognostic significance of new-onset atrial fibrillation in patients with acute myocardial infarction and left ventricular systolic dysfunction: a CARISMA substudy. | The incidence and risk associated with new-onset atrial fibrillation (AF) occurring after discharge in patients with acute myocardial infarction (MI) remains unknown.</AbstractText>This study sought to describe the incidence and clinical risk associated with postdischarge new-onset AF in post-MI patients with left vent... |
5,078 | Mechanical chest compressions with trapezoidal waveform improve haemodynamics during cardiac arrest. | During manual chest compressions for cardiac arrest the waveforms of chest compressions are generally sinusoidal, whereas mechanical chest compression devices can have different waveforms, including trapezoidal. We studied the haemodynamic differences of such waveforms in a porcine model of cardiac arrest.</AbstractTex... |
5,079 | [Early repolarization syndrome and recurrent syncope in two Chinese pedigrees]. | to investigate the clinical characteristics in two families with early repolarization syndrome (ERS) and recurrent syncope.</AbstractText>all family members including the probands were screened with routine clinical examination, electrocardiography, echocardiography, Holter recording, chest x-ray, head-up tilt test and... |
5,080 | A case of aborted sudden cardiac death and consequent extreme electrical storm secondary to a metastatic cardiac tumor. | We report a 43-year-old man with an implantable cardioverter defibrillator for aborted sudden cardiac death. He represents in extreme electrical storm with 111 different ventricular fibrillation episodes. Successful treatment was achieved with multiple antiarrhythmic agents, mechanical ventilation, external shocks, and... |
5,081 | Chronic heart disease and severe obstetric morbidity among hospitalisations for pregnancy in the USA: 1995-2006. | to describe changes in characteristics of delivery and postpartum hospitalisations with chronic heart disease from 1995 to 2006.</AbstractText>cross-sectional study.</AbstractText>USA, nationwide hospital discharge data.</AbstractText>a total of 47 882 817 delivery hospitalisations and 660 038 postpartum hospitalisatio... |
5,082 | Left ventricular hypertrophy determines the severity of diastolic dysfunction in patients with nonvalvular atrial fibrillation and preserved left ventricular systolic function. | Regression of left ventricular (LV) hypertrophy (LVH) is known to be related to a lower incidence of stroke in hypertensive patients with nonvalvular atrial fibrillation (NV-AF). However, its mechanism remains controversial. Recently, diastolic dysfunction (DD) was reported to be correlated with ischemic stroke in NV-A... |
5,083 | A child with influenza A (H1N1)-associated myocarditis rescued by extracorporeal membrane oxygenation. | A 6-year-old boy had cold-like symptoms and was diagnosed with influenza A at a clinic. Administration of oseltamivir and azithromycin did not improve the symptoms. He was referred to our hospital and was diagnosed with H1N1 pneumonia. The patient required ventilator support. However, hypoxia and hypercapnia were uncon... |
5,084 | Gigantic coronary sinus associated with concurrent persistent left superior vena cava and right ventricular volume overload. | A 76-year-old women with known atrial fibrillation and congestive heart failure presented with increasing shortness of breath. A 2-dimensional (2-D) transthoracic echocardiogram was performed to assess left ventricular function. An incidental finding of a very large coronary sinus with a diameter of 4.8 cm was seen, ra... |
5,085 | Appropriate and inappropriate electrical therapies delivered by an implantable cardioverter-defibrillator: effect on intracardiac electrogram. | Local injury current (LIC) seen after induced ventricular fibrillation rescue implantable cardioverter-defibrillator (ICD) shock predicts heart failure progression. We sought to determine the frequency of LIC after spontaneous events in patients receiving ICD therapies.</AbstractText>Near-field (NF) right ventricular (... |
5,086 | Ablation of right-sided accessory pathways with atrial insertion far from the tricuspid annulus using an electroanatomical mapping system. | It is difficult to ablate a right-sided accessory pathway (AP) with atrial insertion far from the tricuspid annulus (TA). We report our initial experience of ablating this rare AP by a 3-dimensional electroanatomical mapping system (CARTO).</AbstractText>From January of 2006 to April of 2008, 18 patients with right-sid... |
5,087 | Intraprocedural imaging of left atrium and pulmonary veins: a comparison study between rotational angiography and cardiac computed tomography. | Atrial fibrillation (AF) ablation is facilitated by anatomical visualization of the left atrium (LA) and the pulmonary veins (PVs). The purpose of this study was to compare accuracy, radiation exposure, and costs between three-dimensional atriography (3D-ATG) and cardiac computed tomography (CCT).</AbstractText>Seventy... |
5,088 | Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response. | Mechanisms regulating stretch response in the left ventricle are investigated in detail but not well understood in atrial myocardium. Hypertrophic growth of atrial myocardium contributes to the pathogenesis of atrial fibrillation. In this study, we sought to elucidate mechanisms of stretch-induced activation of key sig... |
5,089 | Atrial-selective drugs for treatment of atrial fibrillation. | Atrial fibrillation (AF) is accompanied by a high risk of thromboembolic complications necessitating anticoagulation therapy. Arrhythmias have a high tendency to become persistent. Catheter ablation techniques are highly effective in the treatment of AF; however, these procedures are far too costly and time-consuming f... |
5,090 | Therapeutic hypothermia protocol in a community emergency department. | Therapeutic hypothermia (TH) has been shown to improve survival and neurological outcome in patients resuscitated after out of hospital cardiac arrest (OHCA) from ventricular fibrillation/ventricular tachycardia (VF/VT). We evaluated the effects of using a TH protocol in a large community hospital emergency department ... |
5,091 | Automated external defibrillators and survival after in-hospital cardiac arrest. | Automated external defibrillators (AEDs) improve survival from out-of-hospital cardiac arrests, but data on their effectiveness in hospitalized patients are limited.</AbstractText>To evaluate the association between AED use and survival for in-hospital cardiac arrest.</AbstractText><AbstractText Label="DESIGN, SETTING,... |
5,092 | Chaos in the genesis and maintenance of cardiac arrhythmias. | Dynamical chaos, an irregular behavior of deterministic systems, has been widely shown in nature. It also has been demonstrated in cardiac myocytes in many studies, including rapid pacing-induced irregular beat-to-beat action potential alterations and slow pacing-induced irregular early afterdepolarizations, etc. Here ... |
5,093 | Implantable cardioverter defibrillator: charge saver, not syncope saver! | In patients with an implantable cardioverter defibrillator, empirical antitachycardia pacing/burst pacing (ATP) is associated with a significantly decreased rate of appropriate shocks. The use of ATP as first-line therapy in ventricular tachycardia promotes less pain and better quality of life because the number of sho... |
5,094 | The dynamic nature of ventricular tachycardia initiation. | Initiation of ventricular tachycardia (VT) or ventricular fibrillation (VF) requires heterogeneity of the substrate. This heterogeneity has a stable/fixed component (structural or functional) and a dynamic component. The latter explains the random and sudden destabilization of the substrate and the initiation of VT or ... |
5,095 | Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs. | The goal was to terminate atrial fibrillation (AF) by targeting atrioventricular differences in ionic properties.</AbstractText>Optical mapping was used to record electrical activity during carbachol (0.25-0.5 μM)-induced AF in pig hearts. The atrial-specific current, I(Kur), was blocked with 100 μM 4-amino... |
5,096 | Quantitative troponin and death, cardiogenic shock, cardiac arrest and new heart failure in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS): insights from the Global Registry of Acute Coronary Events. | The objective of this study was to determine if the extent of quantitative troponin elevation predicted mortality as well as in-hospital complications of cardiac arrest, new heart failure and cardiogenic shock.</AbstractText>16,318 patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) from the Glob... |
5,097 | Isoproterenol as an adjunct for treatment of idiopathic ventricular fibrillation storm in a pregnant woman. | Idiopathic ventricular fibrillation is a rare entity seen in a very small subset of patients presenting to the emergency department. Management of ventricular arrhythmias in pregnant women is similar to that in nonpregnant women, but special consideration is given to avoid adverse fetal effects when selecting antiarrhy... |
5,098 | Synephrine: from trace concentrations to massive consumption in weight-loss. | Synephrine is cited as 'the active component' of plants and dietary supplements used in weight loss. It became one of the most popular stimulants present in weight-loss products after the US Food and Drug Administration had interdicted the use of ephedrine-containing dietary supplements. Synephrine is also a trace amin... |
5,099 | Transient pseudorestrictive pattern of transmitral flow velocity curve in patients with paroxysmal atrial fibrillation. | Early diastolic velocity of the mitral annulus and transmitral flow propagation velocity are reported as more reliable determinants of left ventricular diastolic function in patients with atrial fibrillation than are transmitral Doppler indices. This study aimed to test the hypothesis that transmitral flow curve shows ... |
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