PMID
int64 35.7M
36.4M
| Title/Abstract
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36,293,306
|
oscbl oscipk modul regul seedl growth confer resist heat drought rice calcium signal pathway critic plant growth develop respons extern stimuli cbl cipk pathway well character calcium signal pathway howev report singl function modul describ examin multipl function modul cipk show similar distribut cbl oscbl oscipk famili retain experienc whole genom duplic event phylogenet synteni analysi studi found oscbl negat regul rice seed germin seedl growth interact oscipk overexpress gene edit mutant plant materi combin plant phenotyp physiolog indic transcriptom sequenc process like mediat osppc member aba signal pathway addit oscbl mediat target osnac osjamyb oscipk thus confer resist high temperatur pathogen rice work reveal uniqu signal pathway wherein oscbl interact oscipk provid rice multipl resist also regul seedl growth
|
D012275
|
T168;T002
|
36,293,305
|
epigenet regul microrna hyperhomocysteinemia acceler atherosclerosi increas serum level homocystein hci risk factor cardiovascular diseas specif link various diseas vasculatur atherosclerosi howev precis mechan hci contribut condit remain elus develop atherosclerosi epigenet modif influenc gene express epigenet modif adapt respons endogen exogen factor lead alter gene express methyl acetyl reaction differ substrat action noncod rna includ microrna mirna epigenet remodel modul cell biolog physiolog physiopatholog condit dna histon modif identifi crucial role progress atherosclerosi howev potenti role mirna hyperhci hhci relat atherosclerosi diseas remain poor explor might essenti well review avail yet summar contribut mirna hyperhomocystein mediat atherogen potenti therapeut target even though import role describ numer studi specif downregul mir mir b shown regul vscms prolifer vitro preclin studi downregul mir mir p shown increas accumul cholesterol foam cell increas macrophag inflamm atherosclerot plaqu format respect anoth preclin studi found reciproc regul mir dnmt hci acceler atherosclerosi interest coupl studi shown mir mir may use potenti biomark patient hhci may develop atherosclerosi moreov current review also updat current knowledg mirna base therapi challeng approach deal hci induc atherosclerosi
|
D020138;D035683;D050197
|
T123;T047;T046;T114
|
36,293,304
|
circul u small nucleolar rna potenti biomark huntington diseas pilot studi plasma small rnas recent explor biomark huntington diseas hd perform exploratori studi nine hd patient eight healthi subject hs five psychiatr patient pp control iatrogen confound effect affymetrix gene chip mirna array valid result independ popul hd pre hd pp alzheim diseas ad patient control diseas specif hs real time pcr microarray result show higher level u small nucleolar rna snord hd patient control fold chang p hd vs hs p hd vs pp valid popul signific increas emerg respect pre hd control group p lt snord correl status mutant huntingtin carrier r p lt diseas durat r p receiv oper characterist roc curv analysi show high accuraci snord discrimin hd patient group auc interactom pathway analysi snord reveal enrich factor relev hd pathogenesi report unpreced find potenti diseas specif role snord hd seem peripher report tip point pathogen cascad neuron level
|
D006816;D035683
|
T123;T047;T114
|
36,293,303
|
two ligand bind site sar cov non structur protein reveal fragment base x ray screen regular reappear coronavirus cov outbreak past year caus signific health consequ financi burden worldwid recent still ongo novel cov pandem caus sever acut respiratori syndrom coronavirus sar cov brought rang devast consequ due except fast develop vaccin mortal rate virus curb signific extent howev limit vaccin effici applic coupl still high infect rate emphasis urgent need discov safe effect antivir sar cov suppress replic attenu virul non structur protein nsp uniqu viral conserv leader protein crucial virul factor caus host mrna degrad suppress interferon ifn express host antivir signal pathway view essenti role nsp cov life cycl regard exploit target antivir drug discoveri report varieti fragment hit n termin domain sar cov nsp identifi fragment base screen via x ray crystallographi also determin structur nsp atom resolut bind affin hit nsp potenti stabilis determin orthogon biophys assay microscal thermophoresi thermal shift assay identifi two ligand bind site nsp one deep one shallow pocket conserv three medic relev sar sar cov mer coronavirus studi provid excel start point develop potent nsp target inhibitor function studi sar cov nsp
|
D000086402;D000086382
|
T005;T067;T047
|
36,293,302
|
microrna b play key role fluorouracil resist predict tumor progress local advanc rectal cancer patient standard clinic manag local advanc rectal cancer larc patient includ neoadjuv fluorouracil fu base chemoradiotherapi crt follow mesorect excis microrna mir b express level larc biopsi obtain initi colonoscopi recent identifi independ predictor patient outcom patholog respons preoper crt diseas moreov discov mir increas express fu resist colon cancer cell fu exposur despit fact observ suggest function role mir b modul fu respons larc cell issu still remain clarifi show downregul mir b enhanc antitumor effect fu treatment moreov ectop mir b modul abl restor sensit fu treatment use acquir resist model compound notabl also evalu potenti clinic impact mir b predict marker diseas progress tumor surgeri resect larc patient observ mir b overexpress signific anticip patient recurr cohort p altogeth find demonstr function role mir b progress decreas sensit fu treatment potenti use therapeut target overcom fu resist well clinic impact predictor tumor progress relaps
|
D012004;D035683
|
T123;T191;T114
|
36,293,301
|
vitro assess poli n vinylpyrrolidoneacryl acid nanoparticl biocompat microvascular endothelium model amphiphil copolym n vinyl pyrrolidon acryl acid name p vp aa od p vp aa synthes prepar p vp aa nanoparticl nps furthermor copolym link cfse prepar nanoparticl load dii dye form nanoparticl dnps studi demonstr immunofluoresc microscopi immunofluoresc confoc microscopi dnps readili taken human microvascular endotheli cell hmec cell concentr depend manner upon uptak cfse dye green stain dii dye red stain local cytoplasm treat cell treatment p vp aa affect viabil normal challeng lps hmec cell mgml induc dose depend decreas cell viabil higher concentr mgml p p respect furthermor focus potenti immunolog activ hmec endotheli cell upon p vp aa nps treatment assess express adhes molecul e selectin icam v cam nps treatment concentr util p ns affect individu adhes molecul express p vp aa nps activ endothelium affect viabil pharmacolog relev concentr
|
D019040;D053758
|
T129;T073;T116;T192
|
36,293,300
|
etiolog ibd still mysteri inflammatori bowel diseas ibd includ coliti ulcerosa crohn diseas chronic diseas gastrointestin tract caus fulli understood howev known etiolog multifactori multidirect network interact environment microbiolog genet factor predispos person lead excess insuffici inhibit reaction immun system lead develop chronic inflamm gastrointestin wall consequ loss function intestin perform inter alia process fibrosi detail knowledg pathway lead chronic inflamm make possibl pharmacolog modul disord effect treatthes diseas review describ primari adapt immun system respons gut known immun pathogenet pathway lead develop ibd also describ process lead intestin tissu fibrosi irrevers consequ untreat ibd
|
D015212;D003093
|
T047
|
36,293,299
|
map valid brgolden domin gene regul carotenoid accumul brassica rapa plant accumul carotenoid maintain balanc photosystem improv crop nutrit qualiti therefor molecular mechan under carotenoid synthesi accumul explor studi carotenoid accumul differ signific among parent brassica rapa genet analysi carri use golden inner leaf line light yellow inner leaf line show golden inner leaf phenotyp control singl domin gene use bulk segreg analysi sequenc braagc encod orang protein select candid gene sequenc align reveal kb long termin repeat insert third exon brgolden result three altern splice transcript spatiotempor express result indic brgolden might regul express level carotenoid synthesi relat gene transform brgolden arabidopsi thaliana seed deriv callus show brgoldenin brgoldendel line present yellow color brgoldenldel line present transpar phenotyp addit use yeast two hybrid assay brgolden in brgolden ldel brgolden wt exhibit strong interact brpsi brgolden del interact brpsi split ubiquitin membran system secondari structur analysi brgolden del shown lost pnfpsfipflppl sequenc amino acid posit result helic brgolden del disrupt restrict format structur affect function protein find may provid new insight regul carotenoid synthesi b rapa
|
D029741;D017360
|
T002
|
36,293,298
|
modif regulatori cell epitop promot effector cell respons aspartylasparaginyl hydroxylas cancer lead caus death worldwid search innov therapeut approach princip focus medic research vaccin strategi target number tumor associ antigen current evalu date none garner signific success purport immunosuppress tumor microenviron accumul regulatori cell contribut lack tumor vaccin efficaci aspartylasparaginyl hydroxylas asph promis therapeut target overexpress varieti malign tumor express neglig normal tissu comput analysi predict asph express four peptid sequenc epitop capabl stimul regulatori cell activ abolit putat regulatori cell epitop increas cd cd effector cell respons monocyt deriv dendrit cell puls modifi epitop deplet version asph ex vivo human lymphoid tissu equival cocultur system simultan decreas overal number foxp regulatori cell find suggest efficaci new vaccin candid would profit screen elimin potenti tolerogen regulatori cell epitop
|
D018984;D009369
|
T129;T191
|
36,293,297
|
puf immobil bjerkandera adusta dsm tool bioremedi creosot oil contamin soil creosot oil byproduct coal distil primarili compos aromat compound difficult degrad polycycl aromat hydrocarbon phenol compound n heterocycl compound despit toxic carcinogen still often use impregn wood particular negat impact condit soil plant impregn wooden materi therefor rapid effect eco friend techniqu elimin creosot soil must develop research focus obtain prepar bjerkandera adusta dsm mycelium immobil polyurethan foam puf contain mold cell amount g dw g carrier obtain enzym prepar use bioremedi soil contamin creosot w w result show appli puf immobil mycelium b adusta dsm week bioremedi respect remov creosot soil week level degrad fluoranthen pyren fluoren respect occur immobil cell potenti larg scale studi sinc degrad creosot oil soil
|
D012989;D055453;D011084
|
T131;T004;T109
|
36,293,296
|
comprehens empir model substitut influenc hydrogen bond aromat schiff base work structur tri ring aromat schiff base differ substitut pattern investig develop unifi descript substitu effect intramolecular hydrogen bridg proxim distal effect examin use densiti function theori dft gas phase solvent reaction field polariz continuum model pcm water solvent order investig character non coval interact topolog analysi perform use quantum theori atom molecul qtaim theori non coval interact nci index obtain result summar general empir model composit substitu effect assess use addit group simpl ring base schiff base composit substitu effect divid separ increment describ differ interact hydrogen bridg substitu classic substitu effect involv reson induct mediat ring steric increment base substitu proxim bridg element distal increment deriv substitut distal ring
|
D012545;D011789
|
T170;T109
|
36,293,295
|
challeng toward novel quaternari sulfid srlncus ln la nd tm unravel synthet pathway structur properti report novel heterometal quaternari sulfid srlncus ln la nd tm obtain singl crystal powder sampl structur singl crystal powder sampl srlacus srndcus belong orthorhomb space group pnma differ structur type sampl srtmcus crystal orthorhomb space group cmcm structur type kzrcus three dimension crystal structur srlacus srndcus form srln cap trigon prism cus tetrahedra srlacus altern layer stack main backbon structur srndcus polymer framework srln n strengthen polymer chain cus n channel fill sr ln cation turn form dimer ribbon crystal structur srtmcus construct srs trigon prism tms octahedra cus tetrahedra latter two polyhedra pack togeth layer separ chain srs n free channel crystal structur srlacus obtain work crystallograph posit strontium lanthanum partial mix structur srndcus solv powder x ray diffract data crystallograph posit strontium neodymium partial mix band gap srlncus ln la nd tm found ev respect srndcus srtmcus found paramagnet k experiment magnet characterist good agreement correspond calcul paramet
|
D028581
|
T196
|
36,293,294
|
descript first regist case lope maciel rodan syndrom russia lope maciel rodan syndrom lomar extrem rare disord case report worldwid lomar caus compound heterozyg mutat htt gene littl known lomar pathogenesi clinic manifest whole exom sequenc wes perform achiev definit molecular diagnosi disord ngs identifi variant underw sanger confirm addit literatur review genet variat htt gene conduct paper report case lomar pediatr patient russia preterm girl non consanguin parent demonstr sever psychomotor development delay first month age year fail develop speech abl understand everyday phrase perform simpl command autism like behavior stereotypi bruxism note examin wes reveal two undescrib variant unknown clinic signific htt gene presum associ patient phenotyp cc gt cc gt medic examin parent reveal patient inherit variant father mother lope maciel rodan syndrom diagnos base overlap clinic find follow genet examin parent find expand number report lomar case provid new insight genet basi diseas
|
D000073359
|
T063
|
36,293,293
|
elev level toxic bile acid serum cystic fibrosi patient cftr mutat caus pancreat insuffici hepatobiliari involv hallmark cystic fibrosi cf causat cf transmembran conduct regul cftr defect express biliari tree howev bile acid ba composit regard pancreat insuffici present earli stage cf patient satisfactorili understood assess pattern serum bas peopl cf pwcf without cftr modul therapi regard pancreat insuffici cftr genotyp pwcf free taurin glycin conjug bas serum prospect assess find relat genotyp pancreat insuffici preval pip score hepat involv indic serum liver enzym well clinic ultrasound criteria cf relat liver diseas serum concentr total primari bas free cholic acid ca signific higher pwcf higher pip score p p respect higher total bas seen pwcf pip score p pancreat insuffici p free ca higher patient cf relat liver involv without cirrhosi compar pwcf without liver diseas fold p pwcf sever cftr genotyp assess pip score reveal toxic ba composit serum subsequ studi assess chang ba homeostasi new high effect cftr modul therapi high interest
|
D003550;D010188;D008107
|
T033;T047
|
36,293,292
|
short peptid innat immun protein tag inhibit product cytokin cfa induc arthriti pathogenesi autoimmun arthriti hot topic current research main focus work studi cytokin releas cfa induc arthriti icr mice well regul blood level cytokin two peptid innat immun protein tag pglyrp capabl block activ tnfr receptor arthriti induc local periarticular singl dose inject l complet freund adjuv cfa left ankl joint mice level chemokin cytokin plasma measur use bio plex pro mous cytokin kit day arthriti induct tag peptid shown decreas blood level pro inflammatori cytokin il tnf il administr peptid also decreas level chemokin mgsacxcl mip cxcl enacxcl migcxcl ip cxcl mcp ccl rantesccl furthermor decreas level cytokin il g csf csf demonstr addit studi peptid strong affect ifn concentr believ decreas level cytokin ifn associ therapeut effect tag peptid manifest allevi destruct cartilag bone tissu cfa induc arthriti
|
D001168;D001169
|
T047;T050
|
36,293,291
|
evalu safeti stewart wood fern dryopteri stewartii anti hyperglycem potenti alloxan induc diabet mice diabet becom critic challeng global health concern cytotox develop resist avail drug manag diabet shift focus global scientif research synthet herbal medic therefor current studi conduct investig possibl anti hyperglycem potenti dryopteri stewartii use swiss albino mice evalu possibl toxic effect plant acut oral toxic test perform anti diabet effect aqueous ethanol extract mgkg posit negat normal control assess simultan anti diabet studi reveal aqueous extract higher anti diabet potenti ethanol extract lower blood glucos level second week reach mgdl exert stronger anti diabet effect compar ethanol extract mgdl oral glucos toler find reveal aqueous extract decreas blood glucos level fold compar ethanol extract show decreas fold histopatholog evalu liver pancrea group reveal normal cell architectur morpholog abnorm result suggest possibl use stewartii anti diabet herbal drug near futur howev recommend condit deep mechanist studi
|
D032492;D003921;D029624
|
T050;T002
|
36,293,290
|
genom wide identif evolut express pattern analysi gata gene famili tartari buckwheat fagopyrum tataricum gata transcript factor exert vital function plant growth develop physiolog metabol environment respons howev gata gene famili rare studi tartari buckwheat sinc complet genom studi use bioinformat method identifi gata gene tartari buckwheat analyz subfamili classif structur composit development evolut well discuss express pattern ftgata gene differ subfamili twenti eight identifi ftgata gene tartari buckwheat genom divid four subfamili distribut eight chromosom one pair tandem repeat gene eight pair fragment found chromosom map spatiotempor express pattern eight ftgata gene differ subfamili indic ftgata gene famili regulatori role tissu specif fruit develop abiot stress hormon respons studi creat theoret scientif foundat research evolutionari relationship biolog function ftgata
|
D019612
|
T168;T002
|
36,293,289
|
cardiac diseas alter myocardi tissu level epoxyeicosatrieno acid key protein involv biosynthesi degrad cypj main epoxygenas heart respons oxid arachidon acid cis epoxyeicosatrieno acid eet form eet hydrolyz solubl epoxid hydrolas seh encod ephx esterifi back membran eet sever cardioprotect properti higher level usual associ better cardiac outcomesprognosi studi investig cardiovascular diseas cvd influenc total eet level alter protein express activ enzym involv biosynthesi degrad diseas ventricular cardiac tissu collect patient receiv left ventricular assist devic lvad heart transplant compar ventricular tissu control free cvd eet enzym involv eet biosynthesi degrad measur use mass spectrometr assay terfenadin hydroxyl use probe cypj activ signific higher cis tran eet level observ control cardiac tissu n relat diseas tissu n control cardiac tissu higher cypj protein level result higher rate terfenadin hydroxyl compar diseas cardiac tissu addit level nadph cytochrom p oxidoreductas por seh protein signific higher control versus diseas cardiac tissu overal alter protein activ enzym involv biosynthesi degrad eet provid mechanist understand decreas eet level diseas tissu
|
D006331;D002318
|
T047
|
36,293,288
|
cpap influenc readili avail inflammatori marker osa pilot studi obstruct sleep apnea osa character repetit upper airway collaps chronic hypoxia proinflammatori phenotyp purpos studi evalu readili avail inflammatori biomark c reactiv protein crp erythrocyt sediment rate esr white blood cell count wbc red cell distribut width rdw neutrophil lymphocyt ratio nlr platelet lymphocyt ratio plr mean platelet volum mpv wbc mpv ratio wmr lymphocyt c reactiv protein ratio lcr cpap patient moder sever osa perform prospect studi includ patient newli diagnos moder sever osa control group patient without osa mild osa select hospit polygraphi databas subject underw routin blood panel repeat moder sever osa patient week cpap final studi group includ control patient mild patient moder patient sever osa crp esr nlr wmr correl osa sever week cpap therapi document decreas weight status remain statist signific cpap adher non adher subgroup readili avail inexpens inflammatori paramet predict presenc moder sever osa influenc short term cpap
|
D002097;D020181
|
T129;T047;T116
|
36,293,287
|
compar genom express analysi insight evolutionari characterist pebp gene cultiv peanut role floral induct phosphatidyl ethanolamin bind protein pebp involv regul flower time various development process function express pattern cultiv peanut arachi hypogaea l remain unknown studi pebp gene cultiv peanut identifi divid four subgroup ft tfl mft ft like gene structur analysi show ortholog b genom cultiv peanut high similar structur ortholog gene subgenom domin gene collinear phylogenet analysi explain pebp gene play key role evolut cis element analysi reveal pebp gene main regul hormon light signal stress relat pathway multipl pepb gene differ express pattern earli late flower genotyp detect respons temperatur photoperiod reveal pebp amp nbsp arahymthpa arahyemvh arahygaqu arahyizfg arahygfp arahylutqn arahydyr arahybbgb key gene control flower respons differ flower time genotyp photoperiod temperatur studi laid foundat function studi pebp gene cultiv peanut adapt peanut differ environ
|
D010367;D018506
|
T045;T002
|
36,293,286
|
psi domain met oncogen encod function disulfid isomeras essenti matur receptor precursor tyrosin kinas receptor encod met oncogen extens studi surpris one extracellular domain psi evolutionari conserv plexin semaphorin integrin establish function met psi sequenc contain two cxxc motif usual found protein disulfid isomeras pdi use scrambl oxid rnase enzymat activ assay vitro show first time met extracellular domain display disulfid isomeras activ abolish psi domain antibodi psi domain delet mutat cxxc site axxa sxxs result signific impair cleavag met kda precursor protein abolish matur chain respect kda kda disulfid link uncleav precursor stuck golgi apparatus interest constitut phosphoryl howev signal transduct observ measur akt mapk phosphoryl consequ biolog respons met ligand hepatocyt growth factor hgf growth epitheli mesenchym transit hamper data show met psi domain function requir matur surfac express biolog function met oncogen protein
|
D017228;D039961
|
T123;T116
|
36,293,285
|
collagen famili promis biomark therapeut target cancer despit advanc cancer detect therapi estim incid cancer increas mortal rate continu remain high fact explain larg number patient diagnos advanc stage therapi often useless therefor necessari invest knowledg resourc develop new non invas biomark earli detect cancer new therapeut target better health manag review provid overview collagen famili promis biomark may exploit therapeut target cancer collagen famili tridimension structur organ function complex tight relationship extracellular matrix tumor immun microenviron moreov accumul evid underlin role collagen promot tumor growth creat permiss tumor microenviron metastat dissemin knowledg molecular basi interact may help cancer diagnosi prognosi overcom chemoresist provid new target cancer therapi
|
D009369
|
T191
|
36,293,284
|
respons rumin microbiota host gene interact high altitud environ tibetan sheep altitud main extern environment pressur affect product perform tibetan sheep adapt evolut mani year form certain respons mechan howev report respons rumin microbiota host genom tibetan sheep high altitud environ conduct integr analysi volatil fatti acid vfas microbi divers rrna epitheli morpholog epitheli transcriptom rumen tibetan sheep differ altitud understand chang rumin microbiota host interact respons high altitud differ nutrit qualiti forag differ altitud especi differ fiber content adfndf led chang rumen vfas tibetan sheep ap valu acet acidpropion acid signific decreas p lt addit concentr iga igg middl altitud high altitud tibetan sheep ha signific increas p lt concentr igm signific increas p lt morpholog result show width rumen papilla thick basal layer increas signific ha tibetan sheep p lt rrna analysi found rumen microbi divers tibetan sheep gradual decreas increas altitud differ phylum genus level microb three altitud rda analysi found abund rikenellacea rc gut group ruminococcacea nka group increas altitud furthermor function analysi kegg microbi databas found lipid metabol function ha tibetan sheep signific enrich wgcna reveal five gene modul enrich energi product convers lipid transport metabol defens mechan cooper microbiota regul rumen ferment epitheli immun barrier function improv metabol immun level tibetan sheep high altitud
|
D012417;D064307
|
T001;T023;T032;T028
|
36,293,283
|
effect low intens puls ultrasound stimul tempor dynam irradi bone tissu heal histomorphometr studi rabbit present studi evalu influenc low intens puls ultrasound lipus regener process non critic size bone defect irradi non irradi rabbit tibia bone defect surgic creat tibia six rabbit control group addit treatment one intervent group one tibia irradi gy singl dose second group treat lipus third combin treatment control sampl show bone repair week irradi bone regener signific less period lipus treatment irradi bone perform bone fill could signific improv respons compar non treat irradi specimen howev lipus treatment non irradi bone show bone format beyond size defect high signific increas compar control group irradi group applic ultrasound healthi bone produc high signific enhanc bone format regener bone compar applic irradi bone lipus vibrat stimuli may consid promis complementari treatment approach non irradi bone regener procedur shorten treatment enhanc bone heal irradi bone effect ultrasound applic less clear studi need refin dynam present result
|
D014464;D001847
|
T061;T047
|
36,293,282
|
compar assess inhibitori potenti herbicid glyphos structur analog rgd specif integrin use enzym link immunosorb assay transmembran glycoprotein integrin play crucial role biochem process inhibit activ differ signal pathway disrupt lead abnorm physiolog function previous demonstr inhibitori effect glyphos herbicid activ ingredi cell adhes v integrin antagonist effect therefor appear particular excit investig inhibit glyphos metabolit wider rang arg gli asp rgd bind integrin name v llb thus purpos studi assess extend inhibitori effect observ glyphos integrin v term rgd integrin structur metabol relat deriv glyphos five differ experiment setup use enzym link immunosorb assay appli v bind synthet polym contain rgd ii v bind extracellular matrix ecm protein vitronectin iii bind polym contain rgd iv llb bind ecm protein fibrinogen v v bind sar cov spike protein receptor bind domain total inhibit v bind rgd detect glyphos main metabolit aminomethylphosphon acid ampa well acetylglycin bind rgd
|
D006540;D000086382
|
T131;T047;T067
|
36,293,281
|
anti inflammatori effect glp r activ retina glucagon like peptid glp incretin hormon main produc enteroendocrin l cell particip regul glucos homeostasi reduct bodi weight promot satieti action glp mediat activ receptor glp r wide express sever tissu includ retina effect glp r activ use manag type diabet mellitus tdm addit activ glp r anti inflammatori effect sever organ suggest may also use treatment inflammatori diseas inflamm common element pathogenesi sever ocular diseas protect effect treatment glp emerg also retin diseas review highlight anti inflammatori effect glp r activ retina first summar pathogen role inflamm ocular diseas describ pleiotrop effect glp r activ cellular compon retina main involv pathogenesi inflammatori retin diseas retin ganglion cell retin pigment epitheli cell endotheli cell
|
D003924;D012164
|
T047
|
36,293,280
|
cspao improv salt toler cucumb interact cspsa affect photosynthesi polyamin convers polyamin oxidas pao key enzym polyamin metabol relat toler plant abiot stress studi overexpress cucumb cucumi sativus l pao cspao arabidopsi result increas activ antioxid enzym acceler convers put spd spm malondialdehyd content mda electrolyt leakag el decreas compar wild type lead enhanc plant growth salt stress photosystem assembl cucumb cspsa reveal interact protein cspao screen yeast two hybrid librari combin vitro vivo method cspao cspsa silenc cucumb via virus mediat gene silenc vig pv empti vector salt stress net photosynthet rate pn transpir rate tr cspao silenc plant lower pv silenc plant el root higher pv silenc plant indic cspao silenc plant suffer serious salt stress damag howev photosynthet paramet cspsa silenc plant higher cspao pv silenc plant therebi enhanc photosynthesi process moreov cspsa silenc reduc el leav root compar cspao silenc plant el leav signific lower two gene silenc plant convers put spd spm leaf also promot suggest cspsa interact cspao leav particip regul salt toler photosynthesi polyamin convers
|
D018553
|
T168;T002
|
36,293,279
|
effect vitamin supplement covid patient systemat review vitamin immun modul effect respiratori tract infect reason propos part treatment covid furthermor vitamin defici associ wors clinic outcom diseas aim systemat review determin whether vitamin supplement modifi diseas cours therefor eleven studi involv randomis clinic trial analys group covid patient without vitamin supplement part treatment compar control group treat best avail therapi clinic trial also placebo accord outcom seem patient benefit receiv daili maintain time vitamin dose regardless vitamin serum level begin trial administr singl vitamin dose seem effect health status patient howev outcom heterogen larger clinic trial necessari
|
D000086382;D014808
|
T047;T067
|
36,293,278
|
hop extract anti inflammatori effect human chondrocyt potenti encapsul rapese lecithin nanoliposom hop humulus lupulus l plant use ingredi beer employ anti inflammatori properti cultiv hop current dedic brew industri main femal flower use wherea aerial part leav consid coproduct osteoarthr common musculoskelet diseas associ low grade cartilag inflamm liposom shown promis system drug deliveri cartilag cell call chondrocyt aim work vector hop extract valor coproduct therapeut agent allevi inflamm human chondrocyt vitro liquid chromatographi allow identif oxid bitter acid methanol extract obtain leav cascad hop extract encapsul rapese lecithin nanoliposom physicochem properti empti load nanoliposom exhibit differ increas concentr hop extract alon empti nanoliposom load nanoliposom test human chondrocyt assess biocompat appropri condit appli chondrocyt stimul interleukin evalu effect inflamm result reveal encapsul potenti hop extract anti inflammatori effect might abl improv joint inflamm osteoarthr furthermor result also show zero wast chain someth achiev hop cultiv
|
D027582;D029688;D029741;D010003
|
T168;T047;T002
|
36,293,277
|
nuclear receptor stress respons pathway associ antineoplast agent induc diarrhea sever case antineoplast agent induc diarrhea may life threaten therefor necessari determin mechan toxic identifi optim manag mechan antineoplast agent induc diarrhea still unclear often consid multifactori aim studi determin molecular initi event mie initi interact molecul biomolecul biosystem evalu mie specif antineoplast agent induc diarrhea detect diarrhea induc drug signal base adjust odd ratio use food drug administr advers event report system use quantit structur activ relationship platform toxic predictor identifi potenti mie specif diarrhea induc antineoplast agent found progesteron receptor antagonist potenti mie associ diarrhea find studi may help improv predict manag antineoplast agent induc diarrhea
|
D011980;D000970
|
T121;T109;T116;T192
|
36,293,276
|
characteris trichomona vaginali isol collect patient vienna trichomona vaginali tv causat agent trichomoniasi common nonvir sexual transmit diseas tv carri symbiont trichomona vaginali virus tvv mycoplasma homini four distinct strain tv known tvv tvv tvv tvv aim current studi characteris tv isol austrian patient presenc symbiont determin effect metronidazol suscept cytotox hela cell collect tv isol detect presenc tvv tvv tvv tvv tvv detect homini detect vaginalurethr swab cultur tv posit patient homini dna found tv isol pcr patient homini detect clinic sampl well within respect tv isol patient homini detect cultur patient homini detect within respect cultur tv isol swab sampl negat homini result provid first insight distribut symbiont tv isol austrian patient observ signific effect symbiont metronidazol suscept cytotox sever symptom
|
D014246;D014245;D019196
|
T047;T005;T204
|
36,293,275
|
polydopamin copolym stabl drug nanoprecipit polydopamin pda biomateri inspir marin mussel attract interest cancer nanomedicin due phototherm properti nanoparticl coat pi pi stack base drug encapsul abil despit numer one pot post polymer modif pda copolym suffici studi context stabil hydrophob drug process nanoprecipit studi test combinatori panel comonom pda optim drug load effici particl size stabil nano formul made via drug nanoprecipit select criterion optim comonom use drug aggreg induc emiss aie identifi trimethyl sulfobutyl benz e indolium novel high use comonom catecholamin optim condit incorpor pda copolym use drug nanoprecipit surpris superior polyethylen glycol modif everi aspect lead copolym poli dopamin poli l dopa co pda pdo shown good stabil sever hydrophob drug result nanoparticl show stabil day high encapsul effici least low toxic high antitumor efficaci vitro nanoprecipit hydrophob drug great enhanc use pda copolym contain easi prepar high effect stabil
|
D011108;D053758
|
T104;T122;T073
|
36,293,274
|
impact cftr modul impair function phagocyt cystic fibrosi lung diseas cystic fibrosi cf common genet inherit diseas caucasian popul multi system life threaten autosom recess disord caus mutat cystic fibrosi transmembran conduct regul cftr gene arriv cftr modul potenti corrector amplifi stabil read agent revolution therapeut approach cf review examin physiopatholog mechan chronic dysregul innat immun respons lung cf patient pulmonari involv particular refer phagocyt critic analyz role cftr modul influenc eventu restor function literatur review highlight role cftr lung crucial epitheli function also host defens particular refer phagocyt macrophag neutrophil cftr dysfunct compromis intric process phagocytosi mechan initi control inflamm reverber epitheli environ alreadi burden chronic colon pathogen lead irrevers tissu damag context investig impact cftr modul phagocyt function therefor crucial explain under mechan pleiotrop effect molecul also better understand physiopatholog basi diseas still part unexplor develop new complementari altern therapeut approach
|
D003550
|
T047
|
36,293,273
|
automat evalu bioengin human artifici ovari model fertil preserv prepubert femal patient malign tumor vitro cultur primordi follicl avail option preserv fertil prepubert girl malign tumor cultiv primordi follicl scaffold artifici ovari promis approach
|
D059247;D009369
|
T061;T191
|
36,293,272
|
alter primari carbon metabol cucumb infect pseudomona syringa pv lachryman local system respons reconfigur primari metabol essenti plant pathogen interact compar local metabol respons cucumb leav inocul pseudomona syringa pv lachryman psl non inocul system leav examin chang nicotinamid adenin dinucleotid pool concentr solubl carbohydr activitiesgen express carbohydr metabol relat enzym express photosynthesi relat gene tricarboxyl acid cycl link metabolit content enzym activ infect leav psl induc metabol signatur alter nad p h nad p ratio decreas glucos sucros content along chang invertas gene express increas glucos turnov accumul raffinos trehalos myo inositol accumul oxaloacet malic acid enhanc activ gene express fumaras l malat dehydrogenas well increas respir rate infect leav indic psl induc tricarboxyl acid cycl chang gene express ribulos l bis phosphat carboxylaseoxygenas larg unit phospho enol pyruv carboxylas chloroplast glyceraldehyd phosphat dehydrogenas compat net photosynthesi declin describ earlier psl trigger metabol chang common infect non infect leav dynam differ quantit eg malic acid content metabol glucos phosphat accumul glucos phosphat dehydrogenas activ specif relat local system respons eg chang sugar content turnov therefor metabol chang system leav may part global effect local infect whole plant metabol also repres specif acclim respons contribut balanc growth defens
|
D018553;D019731
|
T168;T126;T116;T002
|
36,293,271
|
transcriptom analysi marin medaka gill reveal hypo osmot stress could alter immun respons via il signal pathway fish gill major osmoregulatori tissu contact extern water environ develop effect osmoregulatori mechan maintain cellular function marin medaka oryzia melastigma abil live seawat fresh water environ present studi perform seawat sw seawat sfw transfer gill sampl use compar transcriptom analysi studi alter hypo osmot stress immun respons gene model organ result identifi differenti express gene deg sw sfw transfer various pathway p signal forkhead box signal cell cycl enrich moreov immun system highlight one top alter biolog process enrich analysi various cytokin chemokin inflammatori gene particip il signal pathway suppress sw sfw transfer hand immunoglobulin relat gene regul result valid real time qpcr taken togeth studi provid addit gill transcriptom inform marin medaka also support notion osmot stress could influenc immun respons fish gill
|
D009990
|
T013
|
36,293,270
|
mtor contribut proteom divers transcriptom wide altern splice mammalian target rapamycin mtor pathway crucial energi metabol cell prolifer previous report transcriptom wide untransl region utr shorten altern polyadenyl upon mtor activ impact proteom interrog mtor activ transcriptom found hyperactiv mtor promot transcriptom wide exon skippingexclus produc short isoform transcript gene widespread exon skip confer multifari regul mtor control function proteom code region wide affect protein length function domain also alter half life protein affect regulatori post translat modif among rna process factor differenti regul mtor signal found srsf mechanist facilit exon skip mtor activ transcriptom studi reveal role mtor regul demonstr widespread multifacet modul mtor regul function proteom
|
D017398;D059467
|
T123;T045;T114;T081;T086
|
36,293,269
|
serial passag season hn influenza asingaporeg virus mdck siat cell primari chick embryo cell generat ha dg mutat variant ha na pb pb f ns influenza remain one preval virus circul amongst human result sever pandem prevent control hn influenza complic propens evolut lead vaccin mismatch reduc vaccin efficaci studi employ strategi serial passag compar evolut human season influenza strain asingaporeg hn mdck siat versus primari chick embryo fibroblast cef cell genet analysi ha ns na pb gene segment sanger sequenc reveal presenc specif mutat repertoir viral quasispeci follow serial passag quasispeci also found pb exhibit consist high transvers transit ratio five mdck siat passag notabl passag virus harbor dg substitut ha subunit passag virus acquir kq qh mutat pb f variant lead non synonym rq substitut pb also identifi mdck siat passag increas number passag proport dg mutat progress increas associ larger virus plaqu size howev microneutr assay reveal signific differ neutral antibodi profil human influenza immun serum sampl pre passag virus passag virus contrast viabl virus detect passag cef cell gave rise multipl viral rna quasispeci find highlight serial passag abl drive differenti adapt hn influenza differ host speci may alter viral virul studi warrant elucid complex relationship hn virus evolut viral virul chang low vaccin efficaci
|
D009980;D007251;D007252
|
T129;T121;T109;T005;T047
|
36,293,268
|
upregul reg iv hgf mrnas intermitt hypoxia via downregul microrna cardiomyocyt sleep apnea syndrom sas character recurr episod oxygen desatur reoxygen intermitt hypoxia ih risk factor cardiovascular diseas cvd insulin resistancetyp diabet howev mechan link ih stress cvd remain elus expos rat hc mous pcl cardiomyocyt experiment ih normoxia h analyz mrna express sever cardiomyokin found mrna level regener gene iv reg iv hepatocyt growth factor hgf hc pcl cardiomyocyt signific increas ih wherea promot activ gene increas target mrna search microrna mir reveal rat mous mrnas potenti target sequenc mir mir level ih treat cell signific decreas compar normoxia treat cell mir mimic non specif control rna mir mimic nc introduc pcl cell ih induc upregul gene abolish introduct mir mimic mir mimic nc result indic ih stress downregul mir cardiomyocyt result increas level reg iv hgf mrnas lead protect cardiomyocyt sas patient
|
D003924;D035683;D002318
|
T123;T047;T114
|
36,293,267
|
truncat analogu g quadruplex form aptam target mutant huntingtin shorter better two analogu ms aptam previous shown exquisit capabl select bind modul activ mutant huntingtin mhtt design evalu physicochem biolog properti featur distinct propens form complex g quadruplex structur includ larg multimer aggreg origin mer ms truncat give mer name ms mer name ms combin use differ techniqu uv cd dsc gel electrophoresi allow detail physicochem character novel g quadruplex form aptam test vitro sh syy cell vivo drosophila huntington diseas model shorter ms deriv oligonucleotid prove improv bioactiv comparison parent aptam
|
D052157;D009447;D054856;D006816
|
T047;T191;T114;T086
|
36,293,266
|
adipos secret exosom pathophysiolog effect skelet muscl due promin secretori activ adipos tissu consid major player crosstalk organ especi skelet muscl exosom effect carrier intercellular materi transfer wide rang molecul influenc seri physiolog patholog process recipi cell consid under role regulatori mechan adipos secret exosom cellular crosstalk skelet muscl receiv great attent field review describ current known adipos secret exosom well applic skelet muscl pathophysiolog
|
D055354
|
T026
|
36,293,265
|
photoluminesc histidin stabil gold nanoclust effici sensor fast easi visual detect fe ion water use paper base portabl platform herein present novel effici portabl paper base sens platform use paper incorpor histidin stabil gold nanoclust aunc sensit select detect fe ion low volum real water sampl base photoluminesc pl quench high photoluminesc colloid aunc obtain via novel microwav assist method aunc base sensor reveal limit detect lod low good select toward fe ion solut fabric portabl sens devic base paper impregn aunc prove suitabl easi detect hazard fe level real water sampl uv light exposur evalu level pl quench paper photograph imag thereaft captur smartphon camera averag blue intens ratio ii aunc paper spot plot fe reveal lod moreov select competit assay perform paper base sensor prove propos platform present high select accuraci detect fe ion water sampl valid platform sens assay perform real water sampl local sourc spike fe ion ie fe obtain recoveri prove high sensit accuraci propos aunc paper base sensor point toward applic easi use fast quantit qualit sensor suitabl site detect toxic level fe ion low volum real water sampl
|
D006046;D053768
|
T121;T196;T073
|
36,293,264
|
identif candid mrna isoform prostat cancer risk snps util iso eqtl sqtl method singl nucleotid polymorph snps impact altern splice process sqtls isoform express iso eqtl implic import cancer regulatori element find sqtl iso eqtl retriev prostat cancer prca tissu rna seq genotyp data origin prca european patient cancer genom atlas conduct rna seq analysi isoform base splice event base approach matrixeqtl use identifi prca associ sqtls iso eqtl overlap sqtl iso eqtl gwas loci differenti express cancer normal tissu identifi cis act associ fdr lt prca risk snps identifi prca associ cassett exon intron retent mrna isoform belong gene respect assess tran act associ fdr lt yield prca associ cassett exon intron retent mrna isoform belong gene respect result suggest function prca associ snps play role prca genesi make import contribut dysregul consequ impact express mrna isoform
|
D020641;D011471
|
T191;T086
|
36,293,263
|
neutrophil count atrioventricular block avb predictor follow pediatr heart surgeri neutrophil play signific role immun inflammatori reaction preoper inflammatori activ may detriment effect postop outcom aim studi investig relat preoper hematolog indic postop complic risk pediatr cardiac congenit surgeri retrospect singl center analysi includ pediatr patient male femal mean age month refer cardiac surgeri cardiopulmonari bypass due function singl ventricl diseas procedur shunt lesion procedur cyanot diseas procedur among simpl hematolog indic receiv oper characterist curv show neutrophil count kul found optim cut point predict postop atrioventricular block follow pediatr cardiac surgeri auc p lt yield sensit specif preoper valu neutrophil count kul whole blood analysi regard predict factor auc p lt postop atrioventricular block pediatr cardiac surgeri
|
D054537;D006348
|
T061;T047
|
36,293,262
|
ultrason cellulas synergist extract crude polysaccharid moringa oleifera leav allevi insulin resist hepg cell moringa oleifera leav mol new food resourc rich function factor mol polysaccharid import activ macromolecul within mol howev problem low extract rate lack evid function activ therefor experi singl factor experi carri use mol powder raw materi plackett burman test use screen signific influenti test factor extract process mol polysaccharid optim respons surfac methodolog insulin resist allevi activ molp polysaccharid initi explor result show extract moringa oleifera leav crude polysaccharid molp ultrason assist cellulas enzymat digest obtain molp crude polysaccharid averag molecular weight mw kda consist fucos rhamnos arabinos galactos glucos xylos mannos galacturon acid glucuron acid molp ic valu mgml glucosidas scaveng activ free radic abt dpph hydroxyl radic superoxid anion ic valu mgml mgml mgml mgml time molp signific enhanc glucos consumpt glycogen synthesi cat sod gsh px activ reduc mda ros content high glucos induc insulin resist hepg ir hepg cell experi improv extract rate molp demonstr molp antioxid activ glucosidas inhibitori activ allevi insulin resist high glucos induc hepg cell provid partial data support possibl hypoglycem effect molp allevi oxid stress also provid new idea depth studi basic research industri applic molp
|
D029588;D002480;D007333;D061385
|
T121;T116;T126;T046;T002
|
36,293,261
|
monocyt macrophag function divers last decad tremend reviv interest monocyt macrophag
|
D009000;D008264
|
T025
|
36,293,260
|
ketoglutar dehydrogenas complex hub plastic neurodegener regener abnorm glucos metabol central neurodegener consider evid suggest abnorm key enzym tricarboxyl acid tca cycl underli metabol deficit signific recent advanc role metabol cancer provid new insight facilit understand role metabol neurodegener research indic rate limit step tca cycl ketoglutar dehydrogenas complex kgdhc substrat alpha ketoglutar kg serv signal hub regul multipl cellular process rate limit step tca cycl sensit reactiv oxygen speci ros produc ros determin whether kg use energi synthesi compound support growth regul cellular respons hypoxia control post translat modif hundr cell protein mitochondria cytosol nucleus succinyl control critic aspect transcript modul protein signal within cell modul cellular calcium primari focus review understand reduct kgdhc translat patholog import chang underli neurodegener cancer understand role necessari develop new therapeut strategi treat neurodegen diseas
|
D007655;D019636
|
T047;T126;T116
|
36,293,259
|
pesticid impair effect epitheli barrier integr dysbiosi disrupt ahr signal pathway develop immun mediat inflammatori diseas environment occup risk confront agricultur chemic increas presenc natur habitat rise hazard level build major part exposom particular concern low middl incom countri brazil known lead produc agricultur commod consum pesticid long public polici continu encourag indiscrimin use pesticid govern continu support strategi instead endors sustain agricultur altern environment burden damag epitheli barrier continu grow chronic exposur environment contamin earli life affect crucial barrier tissu skin epithelium airway intestin caus increas permeabl leak dysbiosi inflamm serious implic metabol homeostasi vicious cycl exposur environment factor consequ damag epitheli barrier associ increas immun mediat chronic inflammatori diseas understand harm effect pesticid epitheli barrier impact cellular interact mediat endogen sensor coordin success immun system repres crucial challeng line epitheli barrier hypothesi narrat review report avail evid effect pesticid epitheli barrier integr dysbiosi ahr signal consequ develop immun mediat inflammatori diseas
|
D064806;D010575
|
T131;T047;T046
|
36,293,258
|
transport brain extracellular space diffus kind mechan transport substanc brain parenchyma hot topic scientif discuss past decad discuss trigger propos glymphat hypothesi assum direct flow cerebr fluid within parenchyma contrast previous notion diffus main mechan howev discuss issu diffus non diffus much less attent given question diffus differ charact opinion recent publish result fit tradit understand diffus regard outlin relev new theoret approach transport process complex random media concept diffus diffus time depend homogen expand understand form transport substanc base diffus
|
D005110;D001921
|
T023;T030
|
36,293,257
|
reconstruct genom scale metabol model character adapt metabol flux chang peripher blood mononuclear cell sever covid patient coronavirus diseas covid caus sever acut respiratori syndrom coronavirus sar cov pose mortal threat human health elucid relationship peripher immun cell develop inflamm essenti reveal pathogen mechan covid develop relat antivir drug immun cell metabol target therapi exhibit desir anti inflammatori effect treatment case studi base differenti express gene deg analysi genom scale metabol model gsmm reconstruct integr transcriptom data character adapt metabol chang peripher blood mononuclear cell pbmcs sever covid patient differenti flux analysi reveal metabol chang enhanc aerob glycolysi impair oxid phosphoryl fluctuat biogenesi lipid vitamin folat retinol nucleotid play import role inflamm adapt pbmcs moreov main metabol enzym solut carrier slc famili member slca fatti acid synthas fasn respons reaction larg differenti flux identifi potenti therapeut target result reveal inflamm regul potenti partial metabol reaction differenti flux metabolit studi provid refer develop potenti pbmc metabol target therapi strategi covid
|
D000086382
|
T047;T067
|
36,293,256
|
hk butyryl coexist acetyl human spermiogenesi retain matur sperm chromatin male germ cell experi drastic chromatin remodel nucleo histon nucleo protamin nh np transit necessari proper sperm function post translat modif ptms h lys acetyl hkac play crucial role epigenet control nucleosom disassembl facilit protamin incorpor patern dna shown butyryl residu hkbu particip tempor regul nh np transit mice delay bromodomain testi specif protein brdt depend nucleosom disassembl potenti mark retain nucleosom howev inform avail far modif human sperm report dual behavior hkbu hkac human normal spermatogenesi suggest specif role hkbu spermatid elong coexist hkac although differ start point pattern stabl differ testicular patholog suggest high conserv function modif despit drastic decreas ptms condens spermatid retain ejacul sperm non coloc nucleosom cluster could reflect differenti patern genom retent wherea appar effect ptms observ associ sperm qualiti presenc matur sperm could entail potenti role zygot
|
D002843;D009707
|
T123;T116
|
36,293,255
|
longitudin serum protein analysi women high risk develop breast cancer reveal larg interpati versus small intrapati variat first result testbreast studi prospect multicent testbreast studi initi aim identifi novel panel blood base protein biomark enabl earli breast cancer detect moder high risk women serum sampl collect everi half year diagnosi protein level longitudin measur determin intrapati interpati variabl end protein cluster pattern evalu form conceptu basi clinic analys use mass spectrometri base bottom proteom strategi protein abund sampl analyz five sequenti serum sampl six high risk women three develop breast malign case three control serum sampl chromatograph fraction depth serum proteom acquir cluster analys appli indic differ within protein level serum sampl individu statist analys perform use anova select protein high level cluster cluster analys serum sampl reveal uniqu pattern protein cluster patient indic greater interpati intrapati variabl protein level longitudin acquir sampl moreov distinct protein cluster analysi identifi strong cluster pattern within longitudin intrapati sampl demonstr import identifi small chang protein level individu time underlin signific longitudin serum measur patient serv control relev current studi set earli detect testbreast studi continu pursuit toward establish protein panel earli breast cancer detect
|
D001943
|
T191
|
36,293,254
|
current nanomedicin target vascular diseas treatment trend perspect nanotechnolog develop deliv cargo effect vascular system nanomedicin novel effect approach target vascular diseas treatment includ atherosclerosi coronari arteri diseas stroke peripher arteri diseas cancer well known time vascular diseas patient higher cancer risk general popul atherogenesi endotheli cell activ increas express adhes molecul intercellular adhes molecul icam vascular cell adhes protein vcam e selectin p selectin biolog activ endotheli cell give target clue nanoparticl strategi nanoparticl format passiv target pathway due increas adhes molecul express cell surfac well increas cell activ addit vcam target peptid wide use target inflam endotheli cell biomimet nanoparticl use platelet leukocyt membran fragment strategi promis techniqu target vascular diseas treatment cyclodextrin natur oligosaccharid hydrophob caviti increas solubl cholesterol crystal atherosclerot plaqu site use deliv hydrophob drug statin therapeut target manner summari nanoparticl decor various target molecul effect promis strategi target vascular diseas treatment
|
D019161;D014652;D003505
|
T121;T047;T130;T109
|
36,293,253
|
tropaeolum majus rr myb transcript factor tmpap function posit regul anthocyanin biosynthesi anthocyanin import group water solubl non toxic natur pigment antioxid anti inflammatori properti found flower veget fruit anthocyanin biosynthesi regul sever differ type transcript factor includ wd repeat protein transpar testa glabra ttg bhlh transcript factor transpar testa tt glabra gl enhanc gl egl rr myb transcript factor product anthocyanin pigment pap pap myb myb abl form myb bhlh wd mbw complex regul express late biosynthesi gene lbgs anthocyanin biosynthesi pathway nasturtium tropaeolum majus edibl flower plant offer mani health benefit contain numer medicin import ingredi includ anthocyanin compar examin possibl anthocyanin biosynthesi regul gene nasturtium varieti differ anthocyanin content found tmpap rr myb transcript factor gene high express empress india nasturtium varieti high anthocyanin content express tmpap arabidopsi led overproduct anthocyanin protoplast transfect show tmpap function transcript activ consist find biosynthesi gene general phenylpropanoid pathway anthocyanin biosynthesi pathway high express empress india tmpap transgen arabidopsi plant howev protoplast transfect indic tmpap may abl form mbw complex tmgl tmttg result suggest tmpap may function alon key regul anthocyanin biosynthesi nasturtium
|
D017360;D029681;D032388
|
T116;T002
|
36,293,252
|
editori special issu molecular advanc skin diseas pathomechan various skin diseas recent elucid progress
|
D012871
|
T047
|
36,293,251
|
emerg role rna bind protein inner ear hair cell develop regener rna bind protein rbps regul gene express post transcript level play major role tissu stage specif express protein isoform well mainten protein homeostasi inner ear bi function organ cochlea vestibular system requir hear maintain balanc respect relat well document transcript factor signal pathway critic involv format inner ear structur develop hair cell accumul evid highlight emerg function rbps post transcript regul inner ear develop hair cell function import mutat splice factor rbp famili defect altern splice result inappropri express protein isoform lead deaf anim model human rbps critic regul cell prolifer differenti present potenti promot hair cell regener follow nois ototoxin induc damag mitot non mitot mechan therefor deciph rbp regul event inner ear develop hair cell regener help defin therapeut strategi treatment hear loss review outlin evolv understand implic rbps hair cell format hear diseas aim promot futur research field
|
D007758
|
T023
|
36,293,250
|
identif nac transcript factor function aba salin respons nelumbo nucifera nelumbo nucifera gaertn import perenni aquat herb high ornament edibl medicin econom valu wide distribut use china nac superfamili nam ataf cuc play critic role plant growth develop respons abiot biotic stress though report nac gene lotus systemat analysi still relat lack present studi aim character nac gene lotus obtain better insight nnnac respons salt stress depend aba signal nac gene identifi search whole lotus genom base raw hmm model conserv nam domain nac domain character bioinformat analysi divid subgroup base phylogenet tree cis element analysi demonstr nac gene respons biotic abiot stress light low temperatur plant hormon meanwhil nac gene tissu express specif qrt pcr analysi indic nac gene could upregul downregul nacl treatment aba fluoridon addit nac nac nac whose encod gene signific induc nacl aba locat nucleus analysi show three nac protein transcript activ capabl co express network analysi reflect nac protein may form complex protein play role togeth studi provid theoret basi research conduct regulatori mechan salin resist lotus
|
D014157;D031653
|
T123;T116;T002
|
36,293,249
|
antimicrobi peptid k interact distinct eukaryot bacteri membran basi specif bactericid activ sinc penicillin discov antibiot critic fight infect howev antibiot misus led drug resist constitut serious health problem context antimicrobi peptid amp constitut natur group short protein vari structur length act certain type bacteri pathogen antimicrobi peptid k vrlivkvriwrr nh signific bactericid antibiofilm activ listeria monocytogen isol differ strain serotyp salmonella mechan action k explor understand peptid membran interact relev activ defin determin combin studi model synthet membran liposom model biolog membran assess absorpt maximum quench k fluoresc aqueous lipid environ self quench carboxyfluorescein well perform lipid sediment assay data obtain reflect differenti interact k peptid eukaryot prokaryot membran specif interact mechan action three prokaryot speci studi salmonella typhimurium gn escherichia coli gn staphylococcus aureus gp amp k candid prevent food preserv treat antibiot use infect caus certain pathogen bacteria especi resist current antibiot
|
D023181;D008089
|
T129;T123;T007;T116
|
36,293,248
|
chronic nodular prurigo updat pathogenesi treatment chronic nodular prurigo cnpg recalcitr chronic itchi disord affect qualiti life trigger multipl etiolog atop dermat diabet chronic renal diseas mechan cnpg complic involv interact cutan immun nervous system divers immun cell includ eosinophil neutrophil cell macrophag mast cell infiltr lesion skin cnpg initi inflammatori cytokin pruritogen releas addit interact immun cell activ peripher sensori nerv fiber neurotransmitt caus neuroinflamm skin intract itch itch scratch vicious cycl cnpg result diseas exacerb cnpg difficult treat tradit therapi recent great advanc made pathophysiolog inflamm pruritus transmiss cnpg review summar updat mechan novel therapi cnpg
|
D011536;D003876
|
T047
|
36,293,247
|
microbiota serum metabol profil chang korean nativ hanwoo steer respons diet feed system divers bacteria function cattl gastrointestin tract influenc anim welfar next generat sequenc ngs use investig microbi divers fece hanwoo steer rear natur graze gs hous hs system addit serum metabol paramet liver kidney marker miner lipid content chang well correl pyrotag studi total oper taxonom unit otus identifi steer group otus graze steer otus gs chao index analysi reveal higher bacteri rich gs domin bacteri taxa bacteroidet firmicut gs show lower bacteroidet higher firmicut abund hs serum hs show consist increas gamma glutamyl transpeptidas gtp glucos glu total cholesterol cho triglycerid tg level impact gs anim health serum metabol marker strong correl microbiota shown studi graze signific impact fecal microbiota phylum famili level well serum biochem metabolit hanwoo steer
|
D005723;D064307
|
T032;T116;T126;T028;T001
|
36,293,246
|
yinyang balanc communic sensori neuron macrophag traumat peripher neuropath pain traumat peripher neuropath pain complex syndrom caus primari lesion dysfunct peripher nervous system secondari lesion resid infiltr macrophag prolifer initi cross talk sensori neuron level peripher nerv sensori ganglia neuron macrophag interact start earli lesion import promot pain develop initi chang facilit chronic pain also potenti facilit resolut injuri induc chang consequ promot reduct pain review overview uniqu characterist nerv associ macrophag peripher nerv sensori ganglia molecul signal pathway involv neuro immun cross talk traumat lesion final aim better understand balanc pro anti nocicept dialogu neuron macrophag may modul new therapeut approach
|
D009437
|
T184;T047
|
36,293,245
|
cell fate retin progenitor cell ovo ubc startrack analysi clonal cell analysi outlin ontogen potenti singl progenitor cell allow elucid neural heterogen among differ cell type lineag work analyz potenc retin stemprogenitor cell develop use chick embryo model implement ovo clonal genet trace strategi ubc startrack track retin cell lineag deriv individu progenitor ciliari margin e hh clonal assign deriv cell progeni perform neural retina e hh identif sibl cell cell express combin fluorophor moreov cell type assess base cellular morpholog laminar locat ciliari margin deriv cell progeni organ columnar associ distribut along peripher retina limit tangenti dispers analysi reveal earli stage develop region harbor multipot commit progenitor cell
|
D013234;D012160
|
T081;T023;T025
|
36,293,244
|
thermal insul rigid polyurethan foam bio polyol rapese oil modifi phosphorus addit reactiv flame retard articl rigid polyurethan foam obtain addit bio polyol rapese oil modifi dimethyl propan phosphon addit flame retard two reactiv flame retard diethyl hydroxymethyl phosphon diethyl bis hydroxyethyl aminomethylphosphon influenc use flame retard foam process characterist process time test polyurethan system determin obtain foam test term cell structur physic mechan properti well flammabl modifi foam wors mechan thermal insul properti caus lower cellular densiti higher anisotropi coeffici cross section parallel foam rise direct compar unmodifi foam howev thermal conduct test foam materi lower mwmk appli modifi effect reduc flammabl rigid polyurethan foam among other increas oxygen index vol reduc total heat releas rate heat releas correl limit oxygen index valu total heat releas paramet pyrolysi combust flow calorimetri cone calorimetri observ correl also visibl valu heat releas capac hrc paramet obtain pyrolysi combust flow calorimetri maximum averag rate heat emiss marh cone calorimet test
|
D005411;D063065
|
T120;T131;T109
|
36,293,243
|
role vitronectin receptor neuron function neurodegen diseas vitronectin vtn multifunct glycoprotein various physiolog function exist plasma extracellular matrix known involv cell attach spread migrat bind integrin receptor main via rgd sequenc vtn also wide use mainten expans pluripot stem cell effect go beyond recent evid show function vtn nervous system particip neural differenti neuronutrit neurogenesi well regul axon size support guid neurit extens furthermor vtn prove play key role protect brain reduc permeabl blood brain barrier interact integrin receptor vascular endotheli cell moreov evid suggest vtn associ neurodegen diseas alzheim diseas function fulli understood review summar function vtn receptor neuron describ role vtn blood brain barrier neurodegen diseas
|
D019096;D019636
|
T123;T047;T116
|
36,293,242
|
pd bertedl ensembl deep learn method use bert multivari represent predict peptid detect peptid detect defin probabl identifi peptid mixtur standard sampl key step protein identif analysi explor effect method predict peptid detect help diseas treatment clinic research howev exist comput method predict peptid detect reli singl inform increas complex featur represent necessari explor influenc multivari inform peptid detect thus propos ensembl deep learn method pd bertedl bidirect encod represent transform bert introduc captur context inform peptid context inform sequenc inform physicochem inform peptid combin construct multivari featur space peptid use differ deep learn method captur high qualiti featur differ categori peptid inform use averag fusion strategi integr three model predict result solv heterogen problem enhanc robust adapt model experiment result show pd bertedl superior exist predict method effect predict peptid detect provid strong support protein identif quantit analysi well diseas treatment
|
D000077321
|
T066
|
36,293,241
|
quench protein fluoresc fullerenol c oh nanoparticl effect interact fullerenol c oh ful alcohol dehydrogenas adh saccharomyc cerevisia human serum albumin hsa studi absorpt spectroscopi fluoresc spectroscopi time resolv fluoresc spectroscopi shown studi fluoresc intens adh hsa excit wavelength ex nm trp tyr ex nm trp decreas increas ful concentr result time resolv measur indic quench mechan dynam static present bind constant k b number bind site obtain hsa adh thus result indic format ful complex protein howev bind ful hsa much stronger adh transfer energi protein ful also prove
|
D012709;D053758
|
T123;T116;T073
|
36,293,240
|
ampk amplifi il stat signal maintain stabil regulatori cell age mice amp activ protein kinas ampk import regul age process express various immun cell howev role regulatori cell treg stabil age poor understood address role ampk treg function stabil age generat treg specif ampk knockout mice studi found ampk defici treg fail control inflamm effect normal treg age ampk knockout treg reduc stat phosphoryl respons interleukin il stimul therebi destabil treg decreas cd express thus studi address role ampk treg sens il signal amplifi stat phosphoryl turn support treg stabil maintain cd express control inflamm age
|
D050378;D050799
|
T123;T116;T025
|
36,293,239
|
unravel potenti role nedd like e ligas cancer cancer dead diseas worldwid anticip million new case million death occur accord globocan well establish carcinogenesi cancer develop strong link genet chang post translat modif ptms import ptm process ubiquitin regul everi aspect cellular activ crucial enzym ubiquitin process e ubiquitin ligas es affect substrat specif must therefor care regul surfeit studi suggest among e ubiquitin ligas neuron precursor cell express development downregul nedd nedd like e ligas show key function cellular process control subsequ protein degrad substrat ubiquitin addit demonstr nedd main act oncogen various cancer also play tumor suppress role cancer review comprehend proper function nedd cancer develop summar function tumor suppress oncogen role multipl type malign moreov briefli explain role nedd carcinogenesi progress includ cell surviv cell prolifer autophagi cell migrat invas metastasi epitheli mesenchym transit emt chemoresist multipl signal pathway addit briefli explain signific nedd possibl target cancer treatment therefor conclud target nedd therapeut method treat human tumor could practic possibl
|
D044767;D009369
|
T191;T126;T116
|
36,293,238
|
perspect arbuscular mycorrhiz symbiosi rice domest breed natur symbiosi arbuscular mycorrhiz fungi contribut sustain acquisit phosphorus element plant speci improv interact symbiont may mitig environment problem associ fertil applic grain crop rice recent develop high throughput genom sequenc project thousand rice cultivar discoveri molecular mechan under symbiosi suggest interact fungi might overlook critic trait rice domest breed review discuss genet variat abil rice form symbios might affect rice domest final discuss potenti applic symbiosi rice breed sustain agricultur
|
D012275;D038821
|
T168;T004;T002
|
36,293,237
|
correl sperm micro ribonucl acid b c level clinic outcom intracytoplasm sperm inject men male factor infertil studi examin correl sperm mirna level clinic outcom intracytoplasm sperm inject icsi studi aim assess correl sperm mir b mir c mir mir level icsi outcom men teratozoospermia asthenozoospermia taqman microrna quantit polymeras chain reaction use evalu relat express mirna sperm relat mirna level quantifi use compar method found four mirna associ fertil rate earli embryo develop howev revel mir b mir c teratozoospermia sperm live birth group signific higher non live birth group receiv oper characterist curv analysi reveal optim cut delta cycl threshold valu mir b mir c respect statist analysi found level mir b mir c teratozoosperm asthenozoosperm sperm threshold associ fertil rate high qualiti embryo rate howev like exhibit higher implant pregnanc live birth rate mir b mir c signific associ icsi clinic outcom male factor infertil especi teratozoospermia valid requir becom clinic valid refer indic
|
D000072660;D007248;D053627;D035683
|
T184;T123;T033;T114;T047
|
36,293,236
|
reciproc alter osteoprogenitor immun cell popul rheumatoid synovia rheumatoid arthriti ra chronic autoimmun joint inflamm character irrevers joint destruct besid increas resorpt destruct result decreas bone format due suppress differenti function mesenchym lineag deriv osteoblast inflammatori milieu studi analyz cellular composit synovi tissu ra control patient harvest plan surgeri order character resid synovi progenitor popul synovi cell releas collagenas label flow cytometri two antibodi panel cd fitc cd pe aad cdb peci cda apc cd apcef aad cd peci cdcdcda apc cd apcef proport lymphocyt cd cd myeloid cdb cd cell higher synovi tissu patient ra control among non hematopoiet cd cd cda cell decreas proport cd cd increas proport cd cd cell synovi tissu patient ra comparison control patient proport popul associ inflammatori activ could discrimin ra control
|
D013582;D001172
|
T047;T031
|
36,293,235
|
molecular character drought resist gmnac transcript factor glycin max l merr soybean transcript factor gmnac play import role plant resist environment stress studi gmnac clone drought toler soybean varieti jiyu molecular properti gmnac character establish candidaci nac transcript factor yeast self activ experi reveal transcript activ activ gmnac local nucleus subcellular local analysi highest express gmnac detect root pod stage soybean root soybean seedl treat peg h time higher compar control transgen soybean hairi root obtain agrobacterium mediat method treat peg h activ superoxid dismutas peroxidas catalas content prolin increas malondialdehyd content decreas express stress resist relat gene ie apx lea pgdh pcs regul express pattern confirm transgen arabidopsi thaliana overexpress gmnac studi provid strong scientif evid support investig regulatori function gmnac plant drought resist molecular mechan regul plant respons environment stress
|
D055864;D017360
|
T070;T002
|
36,293,234
|
dna penetr lysozym layer surfac aqueous solut interact dna lysozym surfac layer studi perform infrar reflect absorpt spectroscopi irra ellipsometri surfac tensiometri surfac dilat rheolog atom forc microscopi afm concentr dna solut inject aqueous subphas underneath spread lysozym layer optic properti surfac layer chang fast dna inject dynam dilat surfac elast almost chang therebi indic continu network format dnalysozym complex unlik case dna interact monolay cation synthet polyelectrolyt relat fast increas optic signal dna inject lysozym layer indic dna penetr control diffus low surfac pressur afm imag show format long strand surfac layer increas surfac compress lead format network dnalysozym aggreg case mix layer dna synthet polyelectrolyt appear fold ridg layer format disord aggreg presum consequ weaker interact lysozym duplex dna stabil time loop unpair nucleotid high local lysozym concentr surfac layer
|
D009113;D014867
|
T121;T197;T126;T116
|
36,293,233
|
role b lymphocyt pathogenesi nafld updat non alcohol fatti liver diseas relat complic becom one import health problem global liver function metabol immun organ crosstalk hepatocyt intrahepat immun cell play key role coordin dual function liver term protect host antigen overload result receiv nutrient gut microbiota antigen stimul via facilit immunolog toler b cell abund lymphocyt liver crucial role intrahepat b cell energi metabol differ immun condit emerg literatur accumul evid demonstr antibodi cytokin produc b cell microenviron play key distinct role pathogenesi non alcohol fatti liver diseas nafld herein aim consolid updat current knowledg pathophysiolog role b cell well under mechan energi metabol understand b cell exacerb suppress liver damag exploit antibodi cytokin produc great import design b cell target therapi treat various liver diseas
|
D065626;D000069196
|
T047;T007;T001
|
36,293,232
|
base prime edit retina preclin research toward human clinic trial inherit retin diseas ird clinic genet heterogen group diseas one lead caus vision loss young age individu ird main caus loss post mitot photoreceptor neuron retina degener retin pigment epithelium unfortun cell damag irrevers lead perman vision impair thought previous incur gene therapi rapid evolv potenti treatment prevent degener retina preserv visual function develop cluster regular interspac short palindrom repeat crispr crispr associ protein cas base prime editor increas capabl genom edit toolbox recent year base prime editor evad creation doubl strand break deoxyribonucl acid dna requir donor templat dna repair make advantag method develop clinic therapi addit establish perman edit within genom could better suit patient progress degener review summar publish use success base prime edit treat ird
|
D064113;D012164
|
T047;T040
|
36,293,231
|
sar cov spike protein rbd subunit adsorpt abiot surfac corona format polym particl adsorpt kinet sar cov spike protein subunit receptor bind domain abiot surfac investig combin sensit method use atom forc microscopi yield molecular resolut quartz microbal optic waveguid lightmod spectroscopi two latter method yield situ inform protein adsorpt kinet flow condit establish ph protein adsorb mica silica surfac form compact quasi spheric aggreg averag size nm maximum coverag layer equal mg ph respect experiment data success interpret term theoret result deriv model experi perform flat substrat complement investig protein corona format polym particl carri use situ laser doppler velocimetri techniqu way zeta potenti protein layer acquir function coverag appli electrokinet model primari data convert depend subunit zeta potenti ph shown complet acid base characterist layer acquir use nanomolar quantiti protein
|
D000066970;D000086382
|
T047;T116;T067
|
36,293,230
|
clot morpholog acut ischem stroke decis make stroke lead caus death disabl world provis reperfus therapi endovascular therapi particular revolution treatment patient stroke open opportun look brain clot retriev procedur use histopatholog molecular profil clot grow research clinic interest howev clinic implic incorpor within stroke workflow remain suboptim recent studi indic studi brain clot may inform mechan stroke henc guid treatment decis make select group patient especi patient without defin caus known mechan articl provid comprehens overview various clot histopatholog examin acut stroke care set clinic util exist gap opportun research also provid target recommend improv clot analysi workflow henc standard incorpor clinic practic
|
D002545;D000083242;D020521;D013927
|
T047;T046
|
36,293,229
|
complementari dual approach silico target identif potenti pharmaceut compound cystic fibrosi cystic fibrosi genet diseas caus mutat cftr gene encod chlorid bicarbon transport epitheli cell due vast rang geno phenotyp difficult find causat treatment howev small molecul therapeut clinic approv last decad still search novel therapeut ongo thousand compound test differ assay often leav mechan action unknown bring togeth cftr specif compound databas candactcftr system biolog model cftr lifecycl map identifi target promis compound use dual invers screen approach employ target ligand base method suggest target activ compound databas amongst protein target system biolog model overal identifi potenti target compound pair abl suggest target activ compound databas
|
D003550
|
T047
|
36,293,228
|
quantit analysi collect migrat singl cell track aim understand cancer metastasi metastasi major complic cancer treatment studi migratori behavior cell need investig control metastasi metastasi base epitheli mesenchym transit epitheli cell acquir mesenchym properti abil leav popul invad region bodi collect migrat high migratori leader cell found front cell popul well cell follow leader cell howev interact cell well understood examin migrat properti leader follow cell collect migrat singl cell level differ mix ratio leader follow cell popul compar collect migrat quantit analyz two perspect cell migrat within coloni migrat entir coloni analysi effect cell mix ratio migrat behavior show small number high migratori cell enhanc migratori properti cell result provid use insight cellular interact collect cell migrat cancer cell invas
|
D058948;D009369
|
T062;T191
|
36,293,227
|
ella versus simoa serum neurofila assess monitor treatment respons high activ multipl sclerosi patient measur serum neurofila light chain snfl grow import field neurolog manag multipl sclerosi serv use marker assess diseas activ treatment respons paper compar two avail method name singl molecul array simoa ella microfluid platform measur longitudin snfl level high activ multipl sclerosi patient treat alemtuzumab period month order assess method agreement bland altman plot pass bablok regress analyz show despit fact ella measur around higher valu simoa equal suitabl longitudin snfl monitor
|
D009103
|
T047
|
36,293,226
|
character human papillomavirus oncogen khpv mice sublineag drive multi organ carcinogenesi studi human papillomavirus hpv induc carcinogenesi use multipl vivo mous model one reli cytokeratin gene promot drive express hpv earli oncogen studi aim determin hpv variant sublineag present khpv mous model inform consid great import enhanc khpv model essenti research tool optim use basic translat studi studi evalu hpv dna sampl isol anim wild type n hpv transgen mice n total dna extract tissu detect hpv perform use qpcr multiplex hpv posit sampl subsequ whole genom sequenc next generat sequenc techniqu phylogenet posit clear show khpv sampl cluster togeth sub lineag nc compar genom analysi khpv sampl reveal three mutat human papillomavirus type sublineag repres strain knowledg hpv variant fundament find allow ration use anim model explor role sublineag hpv driven cancer
|
D030361;D002583
|
T047;T191
|
36,293,225
|
implic noncod rnas evolut progress nonalcohol fatti liver diseas nafld relat hcc nonalcohol fatti liver diseas nafld preval liver patholog worldwid meanwhil liver cancer repres sixth common malign hepatocellular carcinoma hcc primari preval subtyp due rise incid metabol disord nafld becom one main contribut factor hcc develop howev although nafld might account fourth hcc case current signific gap hcc surveil protocol regard noncirrhot nafld patient major nafld relat hcc case diagnos late stage surviv chanc minim howev past decad focus cancer genom shift toward noncod part genom especi microrna mirna long noncod rnas lncrnas prove involv regul sever malign process review aim summar current knowledg regard main dysregul noncod rnas ncrnas implic nafld hcc develop central focus review mirna lncrnas influenc progress nafld toward hcc use potenti screen tool futur therapeut target
|
D006528;D008113;D065626;D062085;D035683
|
T123;T047;T191;T114
|
36,293,224
|
discoveri simpl diacylhydrazin function cinnam acid deriv potenti microtubul stabil develop novel microtubul bind agent cancer therapi array n cinnamoyl n substitut acryloyl hydrazid deriv facil synthes two step process initi antiprolif activ titl compound explor pc hepg cancer cell line notabl compound exhibit best antiprolif activ three cancer line ic valu rang concurr afford lower cytotox toward nrk e cell anticanc mechan investig suggest high bioactiv compound could potenti promot protofila assembl tubulin thus eventu lead stagnat gm phase cell cycl hepg cell moreov compound also disrupt cancer cell migrat signific induc hepg cell apoptosi dosag depend manner addit silico analysi indic compound exhibit accept pharmacokinet profil overal easili prepar n cinnamoyl n substitut acryloyl hydrazid deriv could serv potenti microtubul interact agent probabl novel microtubul stabil
|
D014404;D000970
|
T123;T121;T116;T109
|
36,293,223
|
differenti analysi glyval glyval mutat affect sarco endo plasmic reticulum ca atpas serca congenit pseudomyotonia romagnola cattl congenit pseudomyotonia cattl pmt rare skelet muscl disord clinic character stiff delay muscl relax exercis muscl relax impair due defect content sarco endo plasmic reticulum ca atpas isoform serca protein caus missens mutat atpa gene pmt repres mammalian model human brodi myopathi romagnola breed two missens variant occur allel describ lead glyval glyval gvgv substitut studi analyz consequ gv gv mutat result support reduc amount serca consequ gv mutat gv mutat almost benign ubiquitin proteasom system up involv block proteasom use proteasom inhibitor found gv mutant accumul cell level compar wt serca conclus gv mutat presum origin fold defect serca protein recogn divert degrad up although still catalyt function main role play gv mutat rescu mutat serca sarcoplasm reticulum membran establish rest cytosol ca concentr prevent appear patholog sign pave way possibl therapeut approach brodi diseas
|
D020386
|
T047
|
36,293,222
|
understand radiobiolog mechan induc lu dotat comparison extern beam radiat therapi radionuclid therapi rnt lu dotat target somatostatin receptor sstrs neuroendocrin tumour net success use routin clinic practic main lead stabl diseas radiobiolog hold promis rnt improv often extrapol extern beam radiat therapi ebrt studi despit differ two radiat base treatment modal panel six human cancer cell line express sstrs common radiobiolog endpoint ie cell surviv cell cycl cell death oxid stress dna damag evalu time lu dotat ebrt treat cell well radiosensit potenti poli adp ribos polymeras inhibit parpi studi show common radiobiolog mechan induc lu dotat ebrt differ extent andor variabl kinet includ dna damag respons higher radiosensit potenti parpi observ ebrt compar lu dotat data reinforc need dedic rnt radiobiolog studi order deriv maximum therapeut benefit
|
D009942;D018358
|
T191;T109
|
36,293,221
|
rat group iia secret phospholipas bind cytochrom c oxidas inhibit activ possibl episod develop alzheim diseas alzheim diseas ad progress form dementia character increas express secret phospholipas group iia giia affect tissu dysfunct neuron mitochondria similar induc ortholog giia snake venom neurotox ammodytoxin atx motor neuron advanc knowledg role giia ad studi effect rat giia neuron mitochondria compar atx produc recombin rat giia rgiia enzymat inact mutant rgiia ds demonstr interact subunit ii cytochrom c oxidas ccox ii atx rgiia rgiia ds bound essenti constitu respiratori chain complex approxim fold lower affin atx nevertheless rgiia molecul potent inhibit ccox activ isol rat mitochondria like atx rgiia abl reach mitochondria pc cell extracellular space independ enzymat activ consist inhibit ccox activ intact pc cell rat brain tissu section clear demonstr use rgiia ds result show effect mammalian snake venom neurotox giia neuron mitochondria similar molecular background suggest elev extracellular concentr giia ad tissu drive transloc enzym local neuron mitochondria inhibit activ ccox respiratori chain consequ process oxid phosphoryl neuron attenu eventu lead degener atx thus reveal valuabl molecular tool investig role giia ad
|
D000544;D054497;D020258
|
T116;T126;T037;T047;T048
|
36,293,220
|
diagnost odyssey adult patient ophthalmolog abnorm hear loss contribut rna seq diagnosi pex defici peroxisom biogenesi disord pbds heterogen group genet diseas multipl peroxisom pathway impair long chain fatti acid vlcfa first line biomark diagnosi clinic present pbds may rang sever lethal multisystem disord milder late onset diseas vast major pbds belong zellweg spectrum disord zsds repres continuum overlap clinic symptom zellweg syndrom sever heimler syndrom less sever diseas mild clinic condit frequent present normal slight biochem alter make diagnosi patient challeng present studi use combin wes rna seq strategi diagnos patient present retin dystrophi main clinic symptom result show patient compound heterozyg mutat pex vlcfa normal retrospect analysi lysosphosphatidylcholin lpc contain c c speci alter simpl test could avoid diagnost odyssey patient mild phenotyp individu describ diagnos late adult life provid function data cell line model may explain mild phenotyp patient demonstr hypomorph natur deep intron variant alter pex mrna process
|
D015211;D006319;D003638
|
T033;T184;T047
|
36,293,219
|
novel antibodi drug conjug target nectin suppress ovarian cancer progress mous xenograft model ovarian cancer fifth lead caus cancer follow front line most platinum agent parp inhibitor limit option later line therefor need altern therapeut option nectin overexpress ovarian cancer known immun checkpoint deregul immun cell function studi generat novel anti nectin antibodi chimer g cg character use epitop map enzym link immunosorb assay surfac plasmon reson fluoresc activ cell sort intern assay cg antibodi specif bound c domain human nectin high affin k mous nectin generat antibodi drug conjug compris cg antibodi conjug dm investig cytotox effect cancer cell vitro vivo cg dm induc cell cycl arrest mitot phase nectin posit ovarian cancer cell nectin negat cancer cell cg dm induc fold cytotox ovarian cancer cell ic rang nm nm compar normal igg dm addit cg dm show tumor growth inhibit mous xenograft model transplant ov cell result suggest cg dm could use potenti therapeut agent nectin posit ovarian cancer
|
D018796;D010051;D008453
|
T129;T121;T191;T109
|
36,293,218
|
clostridioid difficil flagellin activ intracellular nlrc inflammasom clostridioid difficil c difficil major caus nosocomi diarrhea coliti c difficil flagellin flic contribut toxin gut inflamm interact immun toll like receptor tlr activ nuclear factor kappa b nf kb mitogen activ protein kinas mapk signal pathway flagella intracellular pathogen activ nlr famili card domain contain protein nlrc inflammasom pathway studi assess whether flagellin extracellular bacterium c difficil intern epitheli cell activ nlrc inflammasom confoc microscopi show intern recombin green fluoresc protein gfp flic intestin caco tc cell line full length gfp flic activ nlrc caco tc cell contrast truncat gfp flic lack c termin region recogn inflammasom flic induc cleavag pro caspas two subunit p p well gasdermin gsdmd suggest caspas nlrc inflammasom activ addit coloc gfp flic pro caspas observ indic flic depend nlrc inflammasom activ overexpress inflammasom relat interleukin interleukin il il il encod gene well increas il synthesi detect cell stimul inhibit kappa b kinas alpha ikk decreas flic depend inflammasom interleukin gene express suggest role nf b pathway regul inflammasom altogeth result suggest flic intern caco tc cell activ intracellular nlrc inflammasom thus contribut inflammatori process c difficil infect
|
D051198;D016360
|
T007;T116;T192
|
36,293,217
|
tio nanoparticl effect eukaryot cell doubl edg sword nanoparticul tio tio nps wide use materi whose potenti toxic toward eukaryot cell address multipl studi tio nps consid toxic due product reactiv oxygen speci ros among other lead cellular damag inflammatori respons differ gene express tio nps exhibit toxic multipl organ anim generat potenti health risk also human develop tumor progress preexist cancer process hand capabl tio nps induc cell death found applic photodynam therapi cancer aquat environ much done understand impact tio bivalv effect hemocyt among other report advers also report aquat organ includ primari produc affect also land though potenti benefit might exist come agricultur plant tio also lead cellular damag consid come transfer along food chain toward human consum general much work still need done unravel delic balanc benefici detriment effect tio nps eukaryot cell
|
D053758;D053768
|
T073
|
36,293,216
|
novel class proteasom inhibitor silico vitro evalu divers chloro trifluoromethyl aziridin ubiquitin proteasom pathway upp major proteolyt system cytosol nucleus eukaryot cell role proteasom inhibitor pis critic agent regul cancer cell death establish aziridin deriv well known alkyl agent employ cancer howev best knowledg aziridin deriv show inhibitori activ toward proteasom never describ herein report new class select nonpi bear aziridin ring core structur vitro cell base assay two leukemia cell line also display anti prolif activ compound silico studi indic non coval bind mode drug like deriv taken togeth result promis develop potent pis
|
D000970;D001388;D009369
|
T121;T191;T109
|
36,293,215
|
differenti cytotox curcumin load micell human tumor stromal cell although curcumin form nanoparticl demonstr potenti anti tumor compound impact curcumin nanocurcumin vitro normal cell vivo anim model larg unknown studi evalu toxic curcumin load micell vitro vivo sever tumor cell line primari stromal cell zebrafish embryo breast tumor cell line mcf stromal cell human umbil cord vein endotheli cell human fibroblast human umbil cord deriv mesenchym stem cell use studi zebrafish embryotox fet assay conduct follow organis econom co oper develop oecd test compar free curcumin curcumin pm show higher cytotox mcf cell monolay cultur multicellular tumor spheroid curcumin load micell effici penetr mcf spheroid induc apoptosi nanocurcumin reduc viabil disturb function stromal cell suppress cell migrat tube format micell demonstr toxic develop zebrafish embryo curcumin load micell demonstr toxic tumor normal primari stromal cell zebrafish embryo indic use nanocurcumin cancer treatment care investig control
|
D003474;D000970
|
T121;T130;T109
|
36,293,214
|
effect genistein differ concentr mcf breast cancer cell bj dermal fibroblast studi aim evalu safeti potenti use soy isoflavon treatment skin problem difficult heal wound postop scar women oncolog treatment breast cancer effect differ concentr genistein repres soy isoflavonoid mcf tumor cell bj skin fibroblast cultur vitro assess genistein affect healthi dermal bj fibroblast cancer mcf cell effect test isoflavonoid close relat concentr high concentr genistein destroy mcf cancer cell regardless exposur time much greater effect reduc cancer cell number longer time h lower concentr genistein increas abund dermal fibroblast howev higher concentr genistein higher detriment fibroblast longer exposur time h studi indic although genistein show high potenti use treatment skin problem wound surgic scar women breast cancer treatment complet safe introduc isoflavonoid treatment requir research mechan action molecular level take account genet immunolog aspect also necessari conduct research vivo model allow elimin advers side effect therapi
|
D001943;D007529
|
T121;T191;T109
|
36,293,213
|
cd mutat drosophila affect phenoxazinon synthas catalyt site impair long term memori involv develop huntington parkinson alzheim diseas kynurenin pathway kp tryptophan metabol play signific role modul neuropatholog accumul prooxid hydroxykynurenin hok lead oxid stress neuron cell apoptosi drosophila mutant cardin cd hok excess show age depend neurodegener short term memori impair therebi present model senil dementia although cd gene phenoxazinon synthas phs catalyz hok dimer presum harbor cd mutat molecular natur remain obscur use next generat sequenc shown cd gene cd carri long delet lead phs activ site destruct contrari wild type canton cs cd male show defect long term memori ltm condit courtship suppress paradigm ccsp day eclos number dopaminerg neuron dan regul fli locomotor activ show age depend tendenc decreas cd relat cs thus accord concept gene behavior proclaim benzer shown aberr phs sequenc cd provok drastic ltm impair dan alter
|
D004330;D029721
|
T123;T116;T204
|
36,293,212
|
phosphoryl protein serum promis potenti diagnost biomark cancer cancer fatal diseas worldwid year ten million peopl diagnos around world half patient eventu die mani countri major cancer remain asymptomat earlier stage specif symptom appear advanc stage chanc adequ treatment low cancer screen general execut differ imag techniqu like ultrasonographi usg mammographi ct scan magnet reson imag mri imag techniqu howev fail distinguish cancer non cancer cell earli diagnosi confirm imag result solid liquid biopsi done certain limit invas case solid biopsi miss earli diagnosi due extrem low concentr circul tumor dna case liquid biopsi therefor essenti detect certain biomark noninvas approach one approach proteom glycoproteom studi most identifi protein glycoprotein present tissu serum studi approv food drug administr fda anoth non expens compar easier method detect glycoprotein biomark elisa use lectin divers specif sever fda approv protein use cancer biomark show optim sensit precis diagnosi diseas regard express phosphoprotein associ specif stage particular diseas high sensit specif review discuss express differ serum phosphoprotein various cancer phosphoprotein detect either phosphoprotein enrich immunoprecipit use phosphospecif antibodi metal oxid affin chromatographi follow lc msms gel electrophoresi follow maldi tofm analysi updat knowledg phosphoryl protein clinic sampl various cancer patient would help develop serum phophoprotein potenti diagnosticprognost biomark cancer
|
D000074141;D009369
|
T191;T114
|
36,293,211
|
function character heat shock factor crhsf famili provid comprehens insight adapt mechan canavalia rosea sw dc tropic coral island heat shock transcript factor hsfs key regul plant heat stress respons therefor play vital role signal transduct pathway respons environment stress well plant growth develop canavalia rosea sw dc extremophil halophyt good adapt high temperatur salt drought toler use pioneer speci ecolog reconstruct tropic coral island date littl known regard function hsf adapt mechan plant speci special habitat especi tropic legumin halophyt studi genom wide analysi perform identifi hsf c rosea base whole genom sequenc inform chromosom locat protein domain motif organ phylogenet relationship crhsf analyz promot analys indic express level differ crhsf precis regul express pattern also reveal clear transcript chang among differ c rosea tissu indic regul crhsf express vari among organ development tissu specif manner furthermor express level crhsf respons environment condit abiot stress also impli possibl posit regulatori role gene famili abiot stress suggest role adapt special habitat tropic coral island addit crhsfa clone possibl role abiot stress toler function character use yeast express system crhsfa signific enhanc yeast surviv thermal oxid stress challeng result contribut better understand plant hsf gene famili provid basi studi crhsf function environment thermotoler result also provid valuabl inform evolutionari relationship among crhsf gene function characterist gene famili find benefici research natur ecolog adapt c rosea tropic environ
|
D018506;D037421
|
T045;T204
|
36,293,210
|
hepatobiliari thyroid hormon defici impact bile acid hydrophil aquaporin cholestat cblj mice women prone develop either hypothyroid cholesterol gallston men howev male predomin cholesterol gallston hypothyroid report recent novel pathogen link thyroid hormon th defici cholesterol gallston describ male mice investig th defici impact cholesterol gallston format femal mechan three month old cblj mice random divid control th defici lithogen lithogen th defici group diet treat two four six week gallston preval liver function test bile composit hepat gene express gallbladd aquaporin express local investig cholesterol gallston observ lithogen th defici lithogen femal mice diminish hydrophil primari bile acid due decreas gene express hepat detoxif phase ii enzym observ sex specif express local hepatobiliari aquaporin involv transcellular water glycerol permeabl observ th defici lithogen condit th defici promot cholesterol gallston format femal cblj mice mechan observ male howev cholesterol gallston preval lower femal male cblj mice interest sex specif express local hepatobiliari aquaporin could protect femal cblj mice cholestasi could reduc biliari water transport male cblj mice possibl contribut sex depend cholesterol gallston preval th defici
|
D042882;D020346;D002779;D007037
|
T123;T047;T116;T031
|
36,293,209
|
modul p ampkmtor pathway mitochondri dysfunct caus mterf abnorm express colorect cancer cell human mitochondri transcript termin factor mterf demonstr play import role mitochondri gene express regul howev molecular mechan mterf colorect cancer crc remain larg unknown found mterf express signific increas colon cancer tissu compar normal colorect tissu western blot immunohistochemistri tissu microarray tma overexpress mterf ht cell promot cell prolifer migrat invas xenograft tumor format wherea knockdown mterf hct cell appear opposit phenotyp ht cell furthermor mterf increas mitochondri dna mtdna replic transcript protein synthesi colorect cancer cell increas atp level mitochondri crista densiti mitochondri membran potenti oxygen consumpt rate ocr reduc ros product colorect cancer cell therebi enhanc mitochondri oxid phosphoryl oxpho activ mechanist reveal mterf regul ampkmtor signal pathway cancer cell line also confirm involv ampkmtor signal pathway xenograft tumor tissu colorect cancer tissu summari data reveal oncogen role mterf crc progress indic mterf may repres new therapeut target futur
|
D003110;D015179
|
T191
|
36,293,208
|
analys circrna express throughout light dark cycl reveal strong regul cdras associ light entrain scn circular rnas circrna larg class relat stabl rna molecul high express anim brain mani circrna associ cns disord accompani aberr wake sleep cycl howev regul circrna brain homeostasi daili light dark ld cycl character aim quantifi daili express chang circrna physiolog condit healthi adult anim use newli generat public rna seq data monitor circrna express throughout h ld cycl various mous brain region identifi cdras conserv circrna regul synapt transmiss high express suprachiasmat nucleus scn master circadian pacemak despit high stabil cdras dynam express scn throughout ld cycl well signific regul hippocampus follow entri dark phase comput integr differ public dataset predict cdras import regul light entrain scn hypothes express chang cdras scn particular dark phase associ light induc phase shift import work revis current belief natur circrna stabil suggest time compon must consid studi circrna regul
|
D017440;D000079962
|
T079;T114
|
36,293,207
|
vitro anti prolif apoptot effect hydroxytyrosyl oleat sh syy human neuroblastoma cell antitumor activ polyphenol deriv extra virgin oliv oil particular biolog activ htyr studi extens howev use htyr therapeut agent clinic applic limit low bioavail rapid excret human overcom limit sever synthet strategi optim prepar lipophenol new compound deriv htyr increas lipophil bioavail one promis ester hydroxytyrosyl oleat htyr ol chemic structur htyr respons sever biolog activ link monounsatur chain oleic acid oa give compound high lipophil thus bioavail cellular environ studi vitro cytotox anti prolif apoptot induct activ htyr ol evalu sh syy human neuroblastoma cell effect compar htyr oa result show biolog activ htyr maintain htyr ol treatment lower dosag addit shotgun proteom approach use studi htyr ol treat untreat neuroblastoma cell reveal antioxid anti prolif anti inflammatori activ htyr ol observ uniqu protein two group sampl
|
D009447
|
T191
|
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